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Trinucleotide Repeat Protocols
by Yoshinori Kohwi Cynthia T. McmurrayTwo decades have passed since trinucleotide repeat expansion was first discovered in genes responsible for certain neurological diseases. Since then, new technologies have developed and innovative concepts have emerged, which may prove useful in devising therapeutic approaches to neurological diseases. Divided into six convenient sections, Trinucleotide Repeat Protocols, Second Edition covers a wide range of topics such as an overview of trinucleotide repeat diseases, synaptic plasticity, embryonic stem (ES) cell-related protocols with a focus on HD, RNA-related protocols, and analysis of epigenetic modification in fragile X syndrome. This edition focuses not only on direct analysis of trinucleotide repeat diseases but also on alternative approaches for the analysis of trinucleotide repeat diseases, with the hope that this will result in a better understanding of the mechanisms and future therapeutic prospects for treatment of these diseases. Written in the successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Trinucleotide Repeat Protocols, Second Edition seeks to serve researchers with its thorough methodologies on this expanding field.
Trinucleotide Repeats: Methods and Protocols (Methods in Molecular Biology #2056)
by Guy-Franck RichardThis detailed book contains techniques to explore the unusual properties of the peculiar microsatellites known as trinucleotide repeats. Beginning with technical challenges raised by secondary structure-forming repeats and their propensity to contract and expand over time, the book continues with genetic screens in Saccharomyces cerevisiae, experimental systems to study trinucleotide repeat instability in human cells, dedicated experimental systems in appropriate cell types, as well as gene therapy approaches using the CRISPR-Cas family of endonucleases. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Trinucleotide Repeats: Methods and Protocols serves as a valuable aid to experts and newcomers alike who seek to investigate this fascinating and ever-expanding field of study.
Trip: Psychedelics, Alienation, and Change
by Tao LinPart memoir, part history, part journalistic exposé, Trip is a look at psychedelic drugs, literature, and alienation from one of the twenty-first century's most innovative novelists--The Electric Kool-Aid Acid Test for a new generation. A Vintage Original.While reeling from one of the most creative--but at times self-destructive--outpourings of his life, Tao Lin discovered the strange and exciting work of Terence McKenna. McKenna, the leading advocate of psychedelic drugs since Timothy Leary, became for Lin both an obsession and a revitalizing force. In Trip, Lin's first book-length work of nonfiction, he charts his recovery from pharmaceutical drugs, his surprising and positive change in worldview, and his four-year engagement with some of the hardest questions: Why do we make art? Is the world made of language? What happens when we die? And is the imagination more real than the universe?In exploring these ideas and detailing his experiences with psilocybin, DMT, salvia, and cannabis, Lin takes readers on a trip through nature, his own past, psychedelic culture, and the unknown.
Tripping over the Truth: How the Metabolic Theory of Cancer Is Overturning One of Medicine's Most Entrenched Paradigms
by Travis ChristoffersonA masterful synchronization of history and cutting-edge science shines new light on humanity&’s darkest diagnosis.Over 50,000 copies sold! &“Tripping over the Truth will have profound consequences for how cancer is managed and prevented.&”—Thomas N. Seyfried, author of Cancer as a Metabolic DiseaseIn the wake of the Cancer Genome Atlas project&’s failure to provide a legible roadmap to a cure for cancer, science writer Travis Christofferson illuminates a promising blend of old and new perspectives on the disease. Tripping over the Truth follows the story of cancer&’s proposed metabolic origin from the vaunted halls of the German scientific golden age to modern laboratories around the world. The reader is taken on a journey through time and science that results in an unlikely connecting of the dots with profound therapeutic implications.Transporting us on a rich narrative of humanity&’s struggle to understand the cellular events that conspire to form malignancy, Tripping over the Truth reads like a detective novel, full of twists and cover-ups, blind-alleys and striking moments of discovery by men and women with uncommon vision, grit, and fortitude. Ultimately, Christofferson arrives at a conclusion that challenges everything we thought we knew about the disease, suggesting the reason for the failed war against cancer stems from a flawed paradigm that categorizes cancer as an exclusively genetic disease.For anyone affected by this terrifying disease and the physicians who struggle to treat it, this book provides a fresh and hopeful perspective. It explores the new and exciting non-toxic therapies born from the emerging metabolic theory of cancer. These therapies may one day prove to be a turning point in the struggle against our ancient enemy. We are shown how the metabolic theory redraws the battle map, directing researchers to approach cancer treatment from a different angle, framing it more like a gentle rehabilitation rather than all-out combat. In a sharp departure from the current &“targeted&” revolution occurring in cancer pharmaceuticals, the metabolic therapies highlighted have one striking feature that sets them apart—the potential to treat all types of cancer because they exploit the one weakness that is common to every cancer cell: dysfunctional metabolism.With a foreword by Dr. Dominic D&’Agostino, PhD and contributions from Thomas Seyfried, PhD, author of Cancer as a Metabolic Disease; Miriam Kalamian, EdM, MS, CNS, author of Keto for Cancer; and Beth Zupec Kania, consultant nutritionist of The Charlie Foundation.&“Brilliant, timely, and expertly consolidated . . . It reads like a novel and is easy to comprehend for everyone interested in the new conversation around cancer and cancer care. I recommend it to patients, family, friends, and colleagues and refer back to it often.&”—Dr. Nasha Winters, ND, coauthor of The Metabolic Approach to Cancer
Trippy: The Peril and Promise of Medicinal Psychedelics
by Ernesto LondoñoA riveting look at the tremendous promise and inherent risks of the use of psychedelics in mental health treatment through the lens of a New York Times reporter whose journalistic exploration of this emerging field began with a personal crisis.When he signed up for a psychedelic retreat run by a mysterious Argentine woman deep in Brazil’s rainforest in early 2018, Ernesto Londoño, a veteran New York Times journalist, was so depressed he had come close to jumping off his terrace weeks earlier. His nine-day visit to Spirit Vine Ayahuasca Retreat Center included four nighttime ceremonies during which participants imbibed a vomit-inducing plant-based brew that contained DMT, a powerful mind-altering compound.The ayahuasca trips provided Londoño an instant reprieve from his depression and became the genesis of a personal transformation that anchors this sweeping journalistic exploration of the booming field of medicinal psychedelics. Londoño introduces readers to a dazzling array of psychedelic enthusiasts who are upending our understanding of trauma and healing. They include Indigenous elders who regard psychedelics as portals to the spirit world; religious leaders who use mind-bending substances as sacraments; war veterans suffering from PTSD who credit psychedelics with changing their lives; and clinicians trying to resurrect a promising field of medicine hastily abandoned in the 1970s as the United States declared a War on Drugs.Londoño’s riveting personal narrative pulls the reader through a deeply researched and brilliantly reported account of a game-changing industry on the rise. Trippy is the definitive book on psychedelics and mental health today, and Londoño’s in-depth and nuanced look at this shifting landscape will be pivotal in guiding policymakers and readers as they make sense of the perils, limitations, and promises of turning to psychedelics in the pursuit of healing.
Triumph Over Darkness: Understanding and Healing the Trauma of Childhood Sexual Abuse
by Wendy Ann WoodThis collection of prose and therapeutic insights creates a powerful commentary on incest, rape, abuse, and the recovery process. Women and men share their personal experiences of childhood abuse and walk with the reader along the path toward wellness. They reflect each stage of healing with a clarity that, while often painful, is also hopeful. Addressing various aspects of abuse, including ritualistic abuse, multiple personality disorder, and partnering as well as providing a therapist's insights on the stages of healing, Triumph Over Darkness helps readers to understand recovery as a predictable process and see that healing is possible.
Trocar Surgery for Cataract Surgeons: From Dislocated IOL to Dropped Nucleus
by Ulrich SpandauThis book describes how trocar cannulas can be utilized by cataract surgeons in the treatment of complications of cataract injuries. Cataract is still the first cause of blindness in the world, and as such, complications inevitably occur during and after surgery. Trocar surgery has the potential to revolutionize anterior segment surgery, demonstrated here as an easy-to-use technique for conquering the pars plana region. This book describes the simple technique of trocar surgery utilizing trocar cannulas with clear and precise diagrams and video content, making it easy to learn and implement for cataract surgeons.Trocar Surgery for Cataract Surgeons systematically details how trocar surgery can be used to expand the surgical spectrum for cataract surgeons and provide the basis for novel surgical techniques in the field. The videos of this book are available at the Springer Link website.
Trolleyology in Medicine: How the Trolley Problem Sheds Light on Medical Ethics (SpringerBriefs in Ethics)
by Gabriel AndradeThis book provides an overview of how the intricacies of the Trolley Problem shed light on various aspects of medical ethics. It shows how trolley dilemmas have become useful to ethicists to the extent that they activate intuitions and provide guidance about what the relevant moral principle ought to be in judging specific actions. Issues are covered at length such as euthanasia, where it is important to determine a relevant difference between killing and letting die; and abortion, where it is necessary to establish if harms can be used as a means to an end. While specialists in medical ethics have argued about these topics at length, few have established connections with the complexities of trolley cases. The Trolley Problem has now become a staple of pop culture and yet, outside philosophy, few people understand its implications. Consequently, this book is of interest to those with a general interest in philosophy, students, researchers as well as those in the healthcare industry where many of the difficult moral decisions encountered are better informed by framing them around the intricacies of the Trolley Problem.
Tropane Alkaloids: Pathways, Potential and Biotechnological Applications
by Vikas Srivastava Shakti Mehrotra Sonal MishraThis book covers the current research on the biochemistry and biotechnological applications of plant-based Tropane alkaloids. Tropane alkaloids (TA)belong to the world’s oldest phytomedicines with their valuable ethno-pharmacological applications.The book compiles scientific ideas, perspectives and challenges in the application of TA in the present day. The book also provides case studies of Tropane alkaloid bearers. The book attempts to investigate the loop holes in existing methodologies, challenges and possible solutions through well thought-out scientific discussions from various eminent research groups. The book is split into three major sections. The first section includes an overview of Tropane alkaloids and their biosynthesis. This section addresses the biogenesis, evolutionary and ecological perspectives and enzymes in TA biosysnthesis. The second section covers aspects of genetic tools and biotechnological interventions in tropane alkaloid bearing plants. The third section presents various case studies in TA. This book is of high interest to students and researchers in biotechnology, plant biology and pharmacology. Alkaloids are of high medicinal value, and therefore, this book is an interesting read for industry experts, too.
Tropane Alkaloids: Sources, Chemistry, Pharmacology and Biotechnology
by T. Pullaiah Parvatam Giridhar Zhe-Sheng ChenThis book provides comprehensive information on tropane alkaloids, from their discovery to their pharmacological applications and biotechnological production. It focuses on the challenges and opportunities in the sustainable utilization of tropane alkaloid-yielding plants. The book serves as a desk reference for pharmacologists, biomedical scientists, biotechnologists, and herbal drug manufacturers, offering detailed insights into tropane alkaloid research from discovery to commercial production.Key topics include the chemistry and biosynthesis of tropane alkaloids, their occurrence in food commodities, and the cultivation of tropane alkaloid-yielding plants. This volume also explores the pharmacological uses of these compounds, with particular attention to their role as anticholinergic agents. Readers will discover the commercial aspects of tropane alkaloids, including the regulation, use and misuse of cocaine, a well-known narcotic. The authors present a unique combination of theoretical perspectives and practical insights, supported by descriptive illustrations and workflows that facilitate understanding and application, making this an essential guide for researchers and professionals in the pharmaceutical industry.This book is an invaluable resource for researchers, pharmacists, chemists, and industry professionals seeking to deepen their knowledge of tropane alkaloids. It is particularly relevant for those involved in the study or production of these compounds, offering guidance on the propagation of tropane alkaloid-producing plants and alternative production strategies.
Trophy Hunting
by Adam Hart Nikolaj BichelThis book gets to the heart of trophy hunting, unpacking and explaining its multiple facets and controversies, and exploring why it divides environmentalists, the hunting community, and the public. Bichel and Hart provide the first interdisciplinary and comprehensive approach to the study of trophy hunting, investigating the history of trophy hunting, and delving into the background, identity and motivation of trophy hunters. They also explore the role of social media and anthropomorphism in shaping trophy hunting discourse, as well as the viability of trophy hunting as a wildlife management tool, the ideals of fair chase and sportsmanship, and what hunting trophies are, both literally and in terms of their symbolic value to hunters and non-hunters. The analyses and discussions are underpinned by a consideration of the complex moral and practical conflicts between animal rights and conservation paradigms. This book appeals to scholars in environmental philosophy, conservation and environmental studies, as well as hunters, hunting opponents, wildlife management practitioners, and policymakers, and anyone with a broad interest in human–wildlife relations.
Tropical Cardiovascular Pathology: Autopsy-Based Clinicopathological Cases
by Pradeep VaideeswarThe book covers 75 autopsy-based cases (about 75) of common and uncommon presentations of various cardiovascular diseases (CVDs). It emphasizes the importance of the autopsies, which have played a pivotal role in the understanding of the pathology and hence the clinical manifestations of several CVDs. The book attempts to present the material from the perspective of the autopsy table. It uses the clinical data as the initial framework and the autopsy findings to develop a true understanding of the disease and the associated pathophysiology of the condition with final clinico-pathological correlation. Each case covers a complete journey of the deceased patient concisely under the following headings—title, clinical history, autopsy findings and discussion, which includes a brief review of the literature. The text is accompanied by relevant high-quality macroscopic and microscopic images. The book is relevant for specialists in pathology, cardiology, cardiac surgery, internal medicine, critical care and pediatrics
Tropical Diseases in China: Schistosomiasis (Public Health in China #5)
by Xiao-Nong ZhouThis book introduces the changing patterns of schistosomiasis transmission in China at different stages. Arduous efforts have been made in the last 7 decades to control and eliminate schistosomiasis in China using various control strategies, such as snail control to reduce the intensity of the disease transmission, morbidity control to reduce disease prevalence, and integrated control strategies to block the disease transmission, supported by governments at different levels. This book also presents the scientific progresses which technically support the control and surveillance of schistosomiasis in the field. It summarizes the working mechanism and control strategies of multi-sectoral collaboration to promote the national control programme leading to schistosomiasis elimination eventually.
Tropical Hemato-Oncology
by Jean-Pierre Droz Bernard Carme Pierre Couppié Mathieu Nacher Catherine ThiéblemontWhat should you do when you have restricted resources? Written by the most prominent experts from the North and the South countries, this book offers a unique complement to classical hematology and oncology textbooks focusing on specific issues concerning cancers in tropical areas. It presents a thorough review of the specific biological, clinical and therapeutic characteristics of cancers in tropical areas, including their background and epidemiology, public health consequences and transcultural mediation. As such, it will be a valuable resource for all hemato-oncology practitioners, students of oncology or tropical medicine, and other physicians involved in the care of cancer patients who live in tropical countries.
Tropical Medicine: A Clinical Text (8th Edition, Revised and Expanded) (International Humanitarian Affairs)
by Kevin M. CahillThe history of tropical medicine is as dramatic as the story of humankind. It has its own myths and legends, including tales of epidemics that destroyed whole civilizations. Today, with silent stealth, tropical diseases still claim more lives than all the current wars combined. Having had the privilege of working throughout Africa, Asia, and Latin America, as well as in the great medical centers of Europe and the United States, the author presents the details essential for understanding pathogenesis, clinical manifestations, therapy, and prevention of the major tropical diseases. The text, now in its eighth edition, has been used for half a century by medical students, practicing physicians, and public health workers around the world. This fascinating book should also be of interest to a broad, nonmedical readership interested in world affairs.
Tropical Nephrology
by Geraldo Bezerra da Silva Junior Elizabeth De Francesco Daher Elvino BarrosThis unique book provides an introduction to the fascinating field of tropical nephrology, covering nephrology, infectious diseases and tropical medicine. These topics are connected since numerous infectious and parasitic diseases affect the kidneys and are endemic in the tropical areas of the globe. Considered neglected tropical diseases by the World Health Organization, they are largely linked to poverty and lack policies to prevent, treat and decrease their prevalence and incidence. The tropics currently encompass nearly 150 countries and account for 40% of the world's population, and it is predicted that by 2050 this figure will rise to 55%. Most of the countries in the tropical regions have been classified by the World Bank as low-middle income countries and have limited access to services, including health care. As such, this highly topical book is of interest to a large number of healthcare professionals and researchers who are in contact with tropical diseases, especially those investigating their complications, such as kidney injury. Divided into 23 chapters, it describes the most prevalent tropical diseases and conditions that affect the kidneys. It also presents the most recent epidemiological data, clinical manifestations, details of kidney involvement, including the pathophysiology of kidney injury, and the current treatment for each disease.
Trouble in Mind: An Unorthodox Introduction to Psychiatry
by Dean F. MacKinnonOrthodox psychiatric texts are often rich in facts, but thin in concept. Depression may be defined as a dysfunction of mood, but of what use is a mood? How can anxiety be both symptom and adaptation to stress? What links the disparate disabilities of perception and reasoning in schizophrenia? Why does the same situation push one person into drink, drugs, danger, or despair and bounce harmlessly off another? Trouble in Mind is unorthodox because it models adaptive mental function along with mental illness to answer questions like these. From experience as a Johns Hopkins clinician, educator, and researcher, Dean F. MacKinnon offers a unique perspective on the nature of human anguish, unreason, disability, and self-destruction. He shows what mental illness can teach about the mind, from molecules to memory to motivation to meaning.MacKinnon’s fascinating model of the mind as a vital function will enlighten anyone intrigued by the mysteries of thought, feeling, and behavior. Clinicians in training will especially appreciate the way mental illness can illuminate normal mental processes, as medical illness in general teaches about normal body functions. For students, the book also includes useful guides to psychiatric assessment and diagnosis.
Troubled Bodies: Critical Perspectives on Postmodernism, Medical Ethics, and the Body
by Paul A KomesaroffWith transplant surgery, abortion, and radical new technologies for human reproduction and prolonging life as part of our everyday experience, the need to consider ethical issues in medicine almost goes without saying. But the field of traditional biomedical ethics attracts plenty of criticism for its narrow theoretical perspectives and its ignorance of wider philosophical concerns. Troubled Bodies breaks new ground by placing medical ethics in a broad framework of philosophical and cultural analysis. Ten contributors with diverse backgrounds, including medicine and philosophy, biology and social theory, examine how modern medicine regards the human body and its intimate relationship with other aspects of our culture. Certain to provoke vigorous debate, this collection seeks to expand ethical reflection on medicine to include current concerns about the body and the implications of the newer medical technologies for society as a whole.
Troubled Bodies: Critical Perspectives on Postmodernism, Medical Ethics, and the Body
by Paul A. KomesaroffSetting out the implications of the postmodern condition for medical ethics, Troubled Bodies challenges the contemporary paradigms of medical ethics and reconceptualizes the nature of the field. Drawing on recent developments in philosophy, philosophy of science, and feminist theory, this volume seeks to expand familiar ethical reflections on medicine to incorporate new ways of thinking about the body and the dilemmas raised by recent developments in medical techniques.These essays examine the ways in which the consideration of ethical questions is shaped by the structures of knowledge and communication at work in clinical practice, by current assumptions regarding the concept of the body, and by the social and political implications of both. Representing various perspectives including medicine, nursing, philosophy, and sociology, these essays look anew at issues of abortion, reproductive technologies, the doctor-patient relationship, the social construction of illness, the cultural assumptions and consequences of medicine, and the theoretical presuppositions underlying modern psychiatry. Diverging from the tenets of mainstream bioethics, Troubled Bodies suggests that, rather than searching for the correct "coherent perspective" from which to draw ethical principles, we must apprehend the complexity and diversity of the discursive systems within which we dwell.
Troubled Persons Industries: The Expansion of Psychiatric Categories beyond Psychiatry
by Martin HarbuschThis book critiques the use of psychiatric labelling and psychiatric narratives in everyday areas of institutional and social life across the globe. It engages an interpretive sociology, emphasising the medial and individual everyday practices of medicalisation, and their role in establishing and diffusing conceptions of mental (ab)normality. The reconstruction of psychiatric narratives is currently taking place in multiple contexts, many of which are no longer strictly psychiatric. On the one hand, psychiatric narratives now pervade contemporary public discourses and institutions though advertising, news and internet sites. On the other hand, professionals like social workers, teachers, counsellors, disability advisors, lawyers, nurses and/or health insurance staff dealing with psychiatric narratives are becoming servants of the psychiatric discourse within “troubled person’s industries”. Abstract academic categories get turned into concrete aggrieved victims of these categorisations and academic formulas turned into individual narratives. To receive support it seems, one must be labelled. The practice-oriented micro-sociological field with which this volume is concerned has only recently begun to integrate itself into public and academic debates regarding medicalisation and the social role of psychiatry. Discussions on the evolution and expansion of official diagnoses within academia, and society in general, frequently overlook the individualised roles of psychiatric diagnoses and the experiences of those involved and affected by these processes, an oversight which this volume seeks to both highlight and address.
Troubled Water: What's Wrong with What We Drink
by Seth M. SiegelNew York Times bestselling author Seth M. Siegel shows how our drinking water got contaminated, what it may be doing to us, and what we must do to make it safe. If you thought America’s drinking water problems started and ended in Flint, Michigan, think again. From big cities and suburbs to the rural heartland, chemicals linked to cancer, heart disease, obesity, birth defects, and lowered IQ routinely spill from our taps. Many are to blame: the EPA, Congress, a bipartisan coalition of powerful governors and mayors, chemical companies, and drinking water utilities—even NASA and the Pentagon. Meanwhile, the bottled water industry has been fanning our fears about tap water, but bottled water is often no safer.The tragedy is that existing technologies could launch a new age of clean, healthy, and safe tap water for only a few dollars a week per person. Scrupulously researched, Troubled Water is full of shocking stories about contaminated water found throughout the country and about the everyday heroes who have successfully forced changes in the quality and safety of our drinking water. And it concludes with what America must do to reverse decades of neglect and play-it-safe inaction by government at all levels in order to keep our most precious resource safe.
Troubled in the Land of Enchantment: Adolescent Experience of Psychiatric Treatment
by Janis H. Jenkins Thomas J. CsordasIn this groundbreaking study based on five years of in-depth ethnographic and interdisciplinary research, Troubled in the Land of Enchantment explores the well-being of adolescents hospitalized for psychiatric care in New Mexico. Anthropologists Janis H. Jenkins and Thomas J. Csordas present a gripping picture of psychic distress, familial turmoil, and treatment under the regime of managed care that dominates the mental health care system. The authors make the case for the centrality of struggle in the lives of youth across an array of extraordinary conditions, characterized by personal anguish and structural violence. Critical to the analysis is the cultural phenomenology of existence disclosed through shifting narrative accounts by youth and their families as they grapple with psychiatric diagnosis, poverty, misogyny, and stigma in their trajectories through multiple forms of harm and sites of care. Jenkins and Csordas compellingly direct our attention to the conjunction of lived experience, institutional power, and the very possibility of having a life.
Troublesome Disguises
by Dinesh Bhugra Gin S. MalhiSeveral psychiatric disorders remain underdiagnosed in routine clinical practice. This is either because their presentations are fairly atypical and difficult to diagnose and classify, or simply because their rarity makes diagnosis and management problematic. Troublesome Disguises is unique in that it is the only current academic text focussing on this topic. Up-to-date, with detailed management and discussion, the text is international in its scope and readership. With its clinical focus, the book offers comprehensive coverage of such things as disorders of passion, culture-bound syndromes, factitious disorders, paraphilias, reactive psychoses, recurrent brief depression, and neurologic disorders. Containing contributions from a distinguished team of experts assembled from Europe, America and Australia, Troublesome Disguises covers the descriptive aspects, diagnosis and management of these puzzling disorders. This book will prove to be essential reading for a variety of mental-health professionals including psychiatrists, psychiatric trainees, social workers, nurses, psychologists and counsellors, as well as students in the field.
True Age: Cutting-Edge Research to Help Turn Back the Clock
by Morgan Levine, PhDCutting-edge research shows how to determine and decrease your true biological age.What if there was a way to measure our biological age? And what if there were strategies to slow down—or even reverse—the aging process? The answers to these questions lie at the heart of the groundbreaking work Dr. Morgan Levine is doing in her lab at Yale. True Age introduces readers to the latest developments in the science of aging and longevity. It provides an in-depth understanding of biological age and the methods now available to estimate our own. It helps us target an individualized plan to eat, exercise, and sleep, as well as pointing to other lifestyle practices like intermittent fasting and caloric restriction that have been shown to slow or reverse the aging process. The goal is to guide every reader toward a personal regimen to keep them as youthful as possible—both inside and out—with low risk, data-driven biohacking. The book gives readers and their doctors unprecedented ways to identify their personalized aging process and increase not only their lifespan but also then their healthspan.
True Biz: A Reese Witherspoon Book Club Pick
by Sara Novic'Original, tender, thoughtful and true. Can't wait for people to read!' Reese Witherspoon 'Part tender coming of age story, part electrifying tale of political awakening, part heartfelt love letter to Deaf culture, True Biz is a wholly a wonder' Celeste NgA transporting novel that follows a year of seismic romantic, political, and familial shifts for a teacher and her students at a boarding school for the deaf, from the acclaimed author of Girl at War.ONE OF THE MOST ANTICIPATED BOOKS OF 2022 - Oprah Daily, The Millions, Lit Hub, BookPageTrue biz (adj./exclamation; American Sign Language): really, seriously, definitely, real-talkTrue biz? The students at the River Valley School for the Deaf just want to hook up, pass their history finals, and have politicians, doctors, and their parents stop telling them what to do with their bodies. This revelatory novel plunges readers into the halls of a residential school for the deaf, where they'll meet Charlie, a rebellious transfer student who's never met another deaf person before; Austin, the school's golden boy, whose world is rocked when his baby sister is born hearing; and February, the headmistress, who is fighting to keep her school open and her marriage intact, but might not be able to do both. As a series of crises both personal and political threaten to unravel each of them, Charlie, Austin, and February find their lives inextricable from one another - and changed forever.This is a story of sign language and lip-reading, disability and civil rights, isolation and injustice, first love and loss, and, above all, great persistence, daring, and joy. Absorbing and assured, idiosyncratic and relatable, this is an unforgettable journey into the Deaf community and a universal celebration of human connection.