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Adenomyosis: Facts and treatments
by Min Xue Jinhua Leng Felix WongThis book aims to provide updated facts and treatments for practicing gynecologists and postgraduate doctors to enhance their understanding of pathogenesis, pathology, symptoms and diagnostic imaging technology of adenomyosis, such as to select appropriate treatments, to improve the symptoms, fertility and the quality of life of women with adenomyosis. This book also particularly introduces the new treatment for adenomyosis using the non-invasive High Intensity Focused Ultrasound ablation treatment. Hopefully, it will provide a better understanding of its operation, effectiveness, and pregnancy outcome, to formulate a more successful treatment strategy for this disease.
Adenosine: A Key Link between Metabolism and Brain Activity
by Susan Masino Detlev BoisonHomeostasis of key metabolites and metabolic health affects all bodily systems. Not surprisingly, altered metabolic function is associated with a wide spectrum of dysfunctions in the central nervous system - including developmental disorders, acute nervous system injury, and neurodegenerative disorders. Accordingly, metabolism-based therapies offer significant promise as new category of treatment options designed to limit, delay or reverse the disease process by reconstructing homeostatic functions. Increasingly it is appreciated that restoring metabolic health could promote normal nervous system activity, and improve behavior and cognition. Adenosine: A Key Link Between Metabolism and Central Nervous System Activity focusses on diverse aspects of adenosine, an evolutionarily conserved homeostatic bioenergetic regulator in the central nervous system. Because of its interrelationship with ATP (adenosine triphosphate), adenosine is integral to cell metabolism. At the same time, adenosine influences neuronal activity directly via receptors, and is involved in biochemical processes related to gene expression. Thus, adenosine is uniquely placed as a reciprocal and rapid link between changes in metabolism and changes in neuronal activity, and, on a longer time scale, to changes in gene expression and long term changes in cell function. Leaders in the field feature basic research on adenosine at the cellular level in the central nervous system, and relate these findings to its recognized potential in diverse acute and chronic disorders. This comprehensive overview of adenosine also highlights emerging adenosine-based treatments and associated opportunities for central nervous system disorders.
Adenosine and Adenine Nucleotides As Regulators of Cellular Function
by John W. PhillisThis book provides valuable information for investigators interested in the signaling and regulatory functions of adenosine and the adenine nucleotides. Topics covered in this comprehensive volume include the historical development of research on adenosine and adenosine triphosphate; various aspects of the formation, metabolism, release, transport, and receptors for endogenous adenosine and the adenosine triphosphate; functions of purines at the cellular level; the role of adenosine in the regulation of flow in different vascular beds; and angiogenesis. The book also addresses the purinergic regulation of the cardiac, renal, gastro-intestinal, and central nervous system, as well as potential therapeutic avenues for purine use. The book will be valuable to physiologists, pharmacologists, and other basic and clinical scientists interested in updating their knowledge of the expanding biological roles of these substances.
Adenosine Deaminases Acting on RNA (Current Topics in Microbiology and Immunology #353)
by Charles E. Samuel"The objective of this CTMI volume is to provide readers with a foundation for understanding what ADARs are and how they act to affect gene expression and function. It is becoming increasingly apparent that ADARs may possess roles not only as enzymes that deaminate adenosine to produce inosine in RNA substrates with double-stranded character, but also as proteins independent of their catalytic property. Because A-to-I editing may affect base-pairing and RNA structure, processes including translation, splicing, RNA replication, and miR and siRNA silencing may be affected. Future studies of ADARs no doubt will provide us with additional surprises and new insights into the modulation of biological processes by the ADAR family of proteins."
The Adenosine Receptors (The Receptors #34)
by Pier Andrea Borea Katia Varani Stefania Gessi Stefania Merighi Fabrizio VincenziThis book traces the history of adenosine receptor research from molecular biology to medicinal chemistry to behavior, including their implications in disease and potential strategies as therapeutic targets. It provides the reader with a comprehensive overview of the adenosine receptors that includes information on all subtypes - A1, A2A, A2B and A3. Aspects addressed include the most up to date information on their functional distribution in the nervous and peripheral systems, behavioral roles in inflammation, cancer, pain and neurological diseases such as Huntington’s disease, Epilepsy, Parkinson’s disease and Alzheimer’s disease.
Adenosine Receptors: Therapeutic Aspects for Inflammatory and Immune Diseases
by György Haskó Bruce N. Cronstein Csaba SzabóAfter a century of research, several lines of evidence now indicate that the ability of adenosine to directly control inflammatory cells has a major impact on the functions of the inflammatory and immune systems. Consequently, many promising therapeutic approaches are beginning to emerge that focus on the modulation of adenosine, including the deve
Adenosine Receptors in Health and Disease (Handbook of Experimental Pharmacology #193)
by Constance N. Wilson S. Jamal MustafaSince their discovery approximately 25 years ago, adenosine receptors have now emerged as important novel molecular targets in disease and drug discovery. These proteins play important roles in the entire spectrum of disease from inflammation to immune suppression. Because of their expression on a number of different cell types and in a number of different organ systems they play important roles in specific diseases, including asthma, rheumatoid arthritis, Parkinson's disease, multiple sclerosis, Alzheimer's disease, heart disease, stroke, cancer, sepsis, and obesity. As a result of intense investigations into understanding the molecular structures and pharmacology of these proteins, new molecules have been synthesized that have high specificity for these proteins and are now entering clinical trials. These molecules will define the next new classes of drugs for a number of diseases with unmet medical needs.
The Adenosinergic System
by Micaela Morelli Nicola Simola Jadwiga WardasAdenosine A2A receptor antagonists have shown great promise in the treatment of Parkinson's Disease and alleviation of symptoms. This book addresses various aspects of this class of drugs from their chemical development to their clinical use. Among the many insightful chapters contained in this book, there are three unique reviews that have not previously been published in any format: (1) a history of istradefylline, the first A2A antagonist approved for treatment of Parkinson's Disease, (2) an overview of neuroimaging studies in human death and disease and (3) a study of urate as a possible biomarker and neuroprotectant.
Adenovirus Epithelial Keratitis and Thygeson's Superficial Punctate Keratitis: In Vivo Morphology in the Human Cornea
by Helena M. TaberyDespite differences in frequency, causation, and infectivity, adenovirus epithelial keratitis and Thygeson's superficial punctate keratitis (TSPK) are often confused in clinical practice owing to the similarity between adenovirus epithelial infiltrates and 'coarse' epithelial TSPK lesions. This book presents the morphological features, dynamics, and sequelae of adenovirus and Thygeson's keratitides captured at high magnification in the living human cornea. It thereby fills the existing void between conventional photographs and slit-lamp observations. Case reports demonstrate the importance of patient history in differential diagnosis, illustrate the need for familiarity with early manifestations of adenovirus infections, and assist in the diagnosis of rare variants of TSPK. Furthermore, the detailed observations on the natural course of the diseases ensure that the book will serve not only as a diagnostic tool but also as a reference when evaluating the effects of potential new treatments.
Adenovirus Methods and Protocols: Volume 2: Ad Proteins And Rna, Lifecycle And Host Interactions, And Phyologenetics (Methods in Molecular Medicine #21)
by William S. WoldIn Adenovirus Methods and Protocols, William S.M. Wold has organized a collection of readily reproducible methods for conducting research with adenoviruses, the premier and most widely used model in cell and molecular biology. The methods range from how to grow and titer adenoviruses and how to construct specific alterations in the adenovirus genome, to how to measure apoptosis induced by cells of the immune system, cytokines, and intrinsic apoptosis effectors. In addition, there are methods to study transcription and splicing with in vitro systems and for the adenovirus-mediated transformation of cells to a malignant state. Each method is written by a prominent investigator well-versed in the technique and includes a brief background discussion, as well as tried and true step-by-step instructions.<P><P> Adenovirus Methods and Protocols will be useful to both entry-level and senior scientists seeking to enter the adenovirus field, to researchers from other areas wishing to construct adenovirus vectors for their own research, and to adenovirologists wanting to enter new sectors of research. Its cutting-edge techniques are certain to make it today's reference of choice, one from which even expert researchers will learn many productive and time-saving techniques.
Adenovirus Methods and Protocols, Second Edition, Volume 1: Volume 1: Adenoviruses, Ad Vectors, Quantitation, and Animal Models (Methods in Molecular Medicine #130)
by William S. Wold Ann E. TollefsonAdenovirus Methods and Protocols, Second Edition, now in two volumes, is an essential resource for adenovirus (Ad) researchers beginning in the field, and an inspirational starting point for researchers looking to branch into new areas of Ad study. In addition to updating and expanding the first edition, the authors have added new chapters that address innovative areas of emphasis in Ad research, including Ad vector construction and use, real-time PCR, use of new animal models, and methods for quantification of Ad virus or virus expression/interactions. Each of the protocols presented in these volumes is written by trendsetting researchers.
Adenovirus Methods and Protocols, Second Edition, Volume 2: Volume 2: Ad Proteins and RNA, Lifecycle and Host Interactions, and Phyologenetics (Methods in Molecular Medicine #131)
by William S. Wold Ann E. TollefsonAdenovirus Methods and Protocols, Second Edition, now in two volumes, is an essential resource for adenovirus (Ad) researchers beginning in the field, and an inspirational starting point for researchers looking to branch into new areas of Ad study. In addition to updating and expanding the first edition, the authors have added new chapters that address innovative areas of emphasis in Ad research, including Ad vector construction and use, real-time PCR, use of new animal models, and methods for quantification of Ad virus or virus expression/interactions. Each of the protocols presented in these volumes is written by trendsetting researchers.
Adequacy Of Evidence For Physical Activity Guidelines Development: Workshop Summary
by Institute of Medicine of the National AcademiesIs there a sufficient evidence base for the U.S. Department of Health and Human Services (HHS) to develop a comprehensive set of physical activity guidelines for Americans? To address this question, the Institute of Medicine (IOM) held a workshop titled "Adequacy of Evidence for Physical Activity Guidelines Development" in Washington, DC on October 23-24, 2006, sponsored by HHS. The workshop summary includes the presentations and discussions of more than 30 experts who were asked to consider the available evidence related to physical activity and the general population, as well as special population subgroups including children and adolescents, pregnant and postpartum women, older adults, and persons with disabilities. The summary provides an overview of the specific issues of relevance in assessing the quality and breadth of the available evidence.
Adequacy of the VA Persian Gulf Registry and Uniform Case Assessment Protocol
by Committee on the Evaluation of the Department of Veterans Affairs Uniform Case Assessment ProtocolAs mandated in Public Law 103-446, the Department of Veterns Affairs (VA) asked the Institute of Medicine (IOM) to review its Uniform Case Assessment Protocol (UCAP) for Persian Gulf veterans. The purpose of the program is to provide a systematic, comprehensive medical protocol for the diagnosis of health problems of Persian Gulf veterans. This report is the third in a series of studies by IOM reviewing the protocols used by the VA and the Department of Defense to diagnose the health complaints of Gulf veterans. The committee reviews and makes recommendations concerning the adequacy of the medical protocol and its implementation by the VA, as well as the VA's outreach and education efforts aimed at informing Persian Gulf veterans and their care providers of the purpose and availability of this program. In addition, the report contains as appendixes the findings and recommendations of the previous reports, as well as those of two related IOM reports on Health Consequences of Service During the Persian Gulf War.
Adequate Food for All: Culture, Science, and Technology of Food in the 21st Century
by Wilson G. Pond Buford L. Nichols Dan L. BrownFood is the sustenance of life. But while we understand that a secure supply of food has been affected by many factors over the course of history, we do not often allow ourselves to entertain the idea that a lack of adequate food worldwide is a very real and dangerous possibility. While soil degradation, water distribution, climate change, populati
ADHD and Success at Work: How to turn supposed shortcomings into strengths
by Heiner LachenmeierThis book explains, in engaging language, the emotional experience and possible behavioural patterns of ADHD on the bases of its neurobiological function, with a focus on the opportunities and obstacles faced by those with ADHD in professional education as well as in the course of a professional career. A number of conceptualization concerning the central traits of ADHD such as negative hyperfocus, unusual learning curve, questions of selfesteem and emergency-benefits are unfolded for the first time in detail, combined with actionable explanations on how to deal successfully with these traits. In consideration of readers with ADHD, the text is carefully written in a way that grabs your attention with: short sections, numerous illustrations, mini case histories and additional facts as extras. The book is meant for persons with ADHD and their families, for employers and HR responsibles and last but not least for physicians, psychiatrists, psychologists, social workers and other professionals who want to understand in depth the functioning and emotional experiencing of ADHD and how to deal with it in practice.
ADHD and the Edison Gene: A Drug-Free Approach to Managing the Unique Qualities of Your Child
by Thom HartmannExplores how the ADHD gene is and has been critical to humanity’s development • Shows how artists, inventors, and innovators carry the gene necessary for the future survival of humanity • Explains why children with this gene are so often mislabeled in public schools as having a disorder • Offers concrete strategies for helping children reach their full potential In ADHD and the Edison Gene, Thom Hartmann shows that the creativity, impulsiveness, risk taking, distractibility, and novelty seeking that are characteristic of Attention Deficit Hyperactivity Disorder (ADHD) are not signs of a disorder at all but instead are components of a highly adaptive skill set utilized by our hunting and gathering ancestors. These characteristics have been critical to the survival and development of our modern civilization and will be vital as humanity faces new challenges in the future. Hartmann, creator of the “hunter versus farmer” theory of ADHD, examines the differences in neurology between people with ADHD and those without, sharing recent discoveries that confirm the existence of an ADHD gene and the global catastrophe 40,000 years ago that triggered its development. He cites examples of significant innovators with ADHD traits, such as Ben Franklin and Thomas Edison, and argues that the children who possess the ADHD gene have neurology that is wired to give them brilliant success as artists, innovators, inventors, explorers, and entrepreneurs. Emphasizing the role that parents and teachers can play in harnessing the advantages of ADHD, he shares the story of how Edison was expelled from school for ADHD-related behavior and luckily his mother understood how to salvage his self-esteem and prepare him for a lifetime of success. Offering concrete strategies for nurturing, educating, and helping these children reach their full potential, Hartmann shows that rather than being “problems” such children are a vital gift to our society and the world.
ADHD as a Model of Brain-Behavior Relationships (SpringerBriefs in Neuroscience)
by Leonard F. Koziol Deborah Ely Budding Dana ChidekelADHD as a Model of Brain-Behavior Relationships Leonard F. Koziol, Deborah Ely Budding, and Dana Chidekel Series Title: Springer Briefs in Neuroscience Subseries: The Vertically Organized Brain in Theory and Practice It's been a basic neurological given: the brain does our thinking, and has evolved to do the thinking, as controlled by the neocortex. In this schema, all dysfunction can be traced to problems in the brain's lateral interactions. But in scientific reality, is this really true? Challenging this traditional cortico-centric view is a body of research emphasizing the role of the structures that control movement-the brain's vertical organization-in behavioral symptoms. Using a well-known, widely studied disorder as a test case, ADHD as a Model of Brain-Behavior Relationships offers an innovative framework for integrating neuroscience and behavioral research to refine diagnostic process and advance the understanding of disorders. Identifying a profound disconnect between current neuropsychological testing and the way the brain actually functions, this revision of the paradigm critiques the DSM and ICD in terms of the connectedness of brain structures regarding cognition and behavior. The authors argue for a large-scale brain network approach to pathology instead of the localizing that is so common historically, and for an alternate set of diagnostic criteria proposed by the NIMH. Included in the coverage: The diagnosis of ADHD: history and context. ADHD and neuropsychological nomenclature Research Domain Criteria: a dimensional approach to evaluating disorder The development of motor skills, executive function, and a relation to ADHD The role of the cerebellum in cognition, emotion, motivation, and dysfunction How large-scale brain networks interact Heralding a more accurate future of assessment, diagnosis, and treatment of neurodevelopmental disorders, ADHD as a Model of Brain-Behavior Relationships represents a major step forward for neuropsychologists, child psychologists, and psychiatrists, or any related profession interested in a neuroscientific understanding of brain function.
ADHD Does not Exist
by Richard SaulA radical new response to a widely misunderstood conditionWe are witnessing a global epidemic of attention deficit and hyperactivity disorder. Millions are suffering from attention issues, while millions more are reliant on stimulant medication to perform at school and at work. Despite decades of advancements in neuroscience, the definition of ADHD has remained essentially unchanged since its introduction in 1980, and its prevalence in the population has skyrocketed.In this controversial and landmark work, Dr. Richard Saul draws from five decades as a practicing physician and researcher in the field to contend that the definition of ADHD as we know it is completely wrong. Instead, he argues that the "disorder" is a cluster of symptoms stemming from more than twenty other conditions, each requiring separate treatment. The detailed list ranges from mild problems like poor eyesight, sleep deprivation, and even boredom in the classroom, to more severe conditions like depression and bipolar disorder.Through the lens of history and into the present day, Dr. Saul examines "ADHD," exploring the rising cultural and medical trends that have birthed the stimulant epidemic. Both comprehensive and illuminative, ADHD Does Not Exist is essential reading for doctors, practitioners, educators, and individuals who are seeking an honest approach to understanding and treating this complex condition.
ADHD in Adolescents: Development, Assessment, and Treatment
by Stephen P. BeckerBringing together leading authorities, this much-needed volume synthesizes current knowledge about the nature, impact, and treatment of attention-deficit/hyperactivity disorder (ADHD) in the crucial developmental period of adolescence. Contributors explore the distinct challenges facing teens with ADHD as they navigate intensifying academic demands; new risks in the areas of driving, substance use, and romantic relationships; and co-occurring mental health problems. Best practices in clinical assessment are presented. Chapters on treatment--several of which include illustrative case examples--review interventions targeting motivation, executive functioning, and homework problems, as well as applications of cognitive-behavioral therapy and mindfulness. The book also examines medication issues specific to this age group.
ADHD in Adolescents: A Comprehensive Guide
by Alison SchonwaldFinally, everything about ADHD in adolescents is in one place. This book is for you: a clinician diagnosing and treating teens with ADHD, a teacher educating teens with ADHD, or a parent raising one. Written for all readers, this resource is both comprehensive and straightforward, with quick tips and concise guidance in each chapter. Each of the four sections explores an essential aspect of ADHD in adolescents, starting first with detailed yet accessible best-practices of diagnosis and treatment. The second section takes a deep dive into the many disorders that mimic and co-occur with ADHD, including the most up to date information about electronics use and substance use. Section three unpacks the critical topic of Race, Culture, and Ethnicity in ADHD, and the hard-to-find topic of Relationships, Sexuality, and Sexual Behavior in Adolescents with ADHD. The closing and must-read chapters include practical guidance for parenting, thriving in high school, and planning the next steps for success. Across all four sections, clinical scenarios mirror common dilemmas faced by parents and teachers, and recurrent challenges familiar to clinicians. Information and resources direct the reader to best practices in ADHD in adolescents, with useful strategies usable for everyone.Written by experts in the field, ADHD in Adolescents is a valuable guide for all clinicians caring for teens with ADHD: pediatricians, child and adolescent neurologists, child and adolescent psychiatrists, adolescent medicine specialists, psychologists, nurse practitioners, physician assistants, social workers, and licensed clinical mental health workers. Parents and teachers of adolescents with ADHD will find this resource indispensable.
ADHD in Adults: A Practical Guide to Evaluation and Management (Current Clinical Psychiatry #0)
by Craig B.H. SurmanADHD in Adults: A Practical Guide to Evaluation and Management is the product of a unique collaboration of international specialists. This volume offers easy-to-read guidance, and includes checklists, rating scales and treatment planning tools. It was designed for a broad audience of caregivers working in diverse settings, including psychiatrists, social workers, primary care physicians, nurse specialists and psychologists. The authors are highly acclaimed clinicians, investigators and educators. They offer step-by-step guidance for implementation of best practices, drawing from clinical research and their experience treating thousands of patients. They cover diagnosis, treatment planning, and state-of-the-art application of pharmacology, psychotherapy, skill-building, family system and environmental interventions - for both simple and complex cases. The scales and worksheets in this Guide were developed to efficiently facilitate assessment and management. The Editor is an international leader in the field from the Clinical and Research Program in Adult ADHD at Massachusetts General Hospital (MGH) and Harvard Medical School, which has made pioneering and highly cited contributions to the understanding of ADHD. This Guide is a definitive, indispensable resource for all health providers who wish to optimize their approach to adult patients with ADHD.
ADHD in Adults: What the Science Says
by Kevin Murphy Russell BarkleyProviding a new perspective on ADHD in adults, this compelling book analyzes findings from two major studies directed by leading authority Russell A. Barkley. Groundbreaking information is presented on the significant impairments produced by the disorder across major functional domains and life activities, including educational outcomes, work, relationships, health behaviors, and mental health. Thoughtfully considering the treatment implications of these findings, the book also demonstrates that existing diagnostic criteria do not accurately reflect the way ADHD is experienced by adults, and points the way toward developing better criteria that center on executive function deficits. Accessible tables, figures, and sidebars encapsulate the study results and methods.
ADHD in the Schools, Third Edition: Assessment and Intervention Strategies
by George J. Dupaul Gary Stoner Robert ReidThis highly regarded practitioner guide provides state-of-the-art tools for supporting the academic and behavioral success of PreK-12 students with attention-deficit/hyperactivity disorder (ADHD). The authors explain the learning and behavior difficulties associated with ADHD and describe screening and assessment procedures that facilitate data-based decision making. They show how to develop individualized intervention plans that integrate behavioral, academic, and social supports, in partnership with teachers and parents. Strategies for collaborating with physicians and monitoring students' medication response are also presented. Helpful reproducible forms and handouts can be downloaded and printed in a convenient 8 1/2" x 11" size. New to This Edition: *Reflects a decade's worth of research and clinical advances, plus the growth of multi-tiered service delivery models. *Discusses changes in DSM-5. *Separate chapter on interventions for middle and high school students, with new content on the transition to college. *Updated medication information, case examples, and more.
ADHD in the Schools, Third Edition
by Robert Reid Gary Stoner George J. DupaulThis highly regarded practitioner guide provides state-of-the-art tools for supporting the academic and behavioral success of K-12 students with attention-deficit/hyperactivity disorder (ADHD). The authors explain the learning and behavior difficulties associated with ADHD and describe screening and assessment procedures that facilitate data-based decision making. They show how to develop individualized intervention plans that integrate behavioral, academic, and social supports, in partnership with teachers and parents. Strategies for collaborating with physicians and monitoring students' medication response are also presented. Helpful reproducible forms and handouts can be downloaded and printed in a convenient 8 1/2" x 11" size. New to This Edition: *Reflects a decade's worth of research and clinical advances, plus the growth of multi-tiered service delivery models. *Discusses changes in DSM-5. *Separate chapter on interventions for middle and high school students, with new content on the transition to college. *Updated medication information, case examples, and more.