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Biomolecules' Conformational Changes Studied by Simulations and Enhanced Sampling (Springer Theses)
by Yui Tik PangThis thesis illuminates the critical roles biomolecules, from small molecules to proteins, play in cellular functionality, particularly highlighting their conformational changes in response to environmental cues or binding events—a cornerstone concept in drug design as well as the manifestations of disease. It explores the conformational flexibility of small molecules and proteins, essential for predicting drug interactions and understanding biological processes. Through advanced molecular dynamics simulations and enhanced sampling techniques, this research offers unprecedented insights into the structural dynamics of three distinct biomolecular systems: the capsid assembly modulator AT130, the passenger domain of pertactin, and the SARS-CoV-2 spike protein. Each system represents a unique facet of biological complexity, underscoring the thesis's contribution to our understanding of biomolecular behavior across various scales. Furthermore, the thesis advances the field by updating the Force Field Toolkit for improved simulation accuracy. This work not only showcases the adaptability and importance of simulation techniques in modern biological research but also paves the way for novel therapeutic strategies by deepening our understanding of biomolecular dynamics.
Biomolecules: Chemistry of Living System
by V.K. AhluwaliaBiomolecules, also known as molecules of life, are essential for sustaining life processes. This book presents a study of these crucial biological substances to explore their function, structure, biological role, and synthesis. It also expands upon the various types of biomolecules and discusses their individual characteristics.The subject matter of this book also covers: Mucopolysaccharides Tertiary Structure of Proteins Caffeine Mechanism of Enzyme Action Biosythesis of Haemoglobin Print edition not for sale in South Asia (India, Sri Lanka, Nepal, Bangladesh, Pakistan or Bhutan)
Biomonitoring of Pollutants in the Global South
by Sylvester Chibueze Izah Matthew Chidozie Ogwu Hossein HamidifarThe edited book serves as a reference on indicators of environmental pollution and how to sustainably ascertain the effects of different pollutants on life forms. It addresses an improved technology for monitoring contaminants, especially in the Global South and beyond, where the level of technology available for sustainable management of environmental quality is limited. Biomonitoring ecosystems' health by using organisms to gather quantitative data on environmental quality is one of the most straightforward and affordable ways to check environmental quality. Since organisms may function as environmental sensors, their use in the direct measurement of environmental quality in the process of biomonitoring studies implicates the health status of various ecosystems. In this regard, microorganisms, higher and lower plants, invertebrates, and vertebrate animals are beneficial since they can detect pollution levels and pollutants in the environment. This book is of interest and useful to toxicologists, water, soil, and air quality experts, practitioners, trainees, and trainers, biological sciences scientists, academicians, researchers, students (especially undergraduates and postgraduates), libraries, and other public knowledge repositories interested in novel and advanced practices in sustainable biomonitoring of environmental pollutants.
Biomonitoring of Water and Waste Water
by Krishna Gopal Anju AgrawalBiomonitoring of water quality is very much essential for assessing the overall health of water bodies and safe supply of drinking water. The chemical nature of toxicant is highly dynamic in environment with time and space whereas biological system can integrate all environmental variables over a large period of time in terms of effect that can be easily measured and quantified. In view of the above, there is a pressing need to determine the water quality of natural resources as well as drinking water based on the standard protocols and guidelines from regulatory agencies. It is clear that the synthetic chemicals are essential for our society to maintain the health and well being of the people. However, there has been a range of detrimental effects on human health and natural environment. In general, we need to improve our management of waste chemicals discharged into the air, water and soil environments. New techniques are needed to predict adverse effects before they occur and for the treatment of wastes. In addition, a range of social, political and economic factors will be needed to be taken into account in order to achieve success.
Biomotors and their Nanobiotechnology Applications
by Peixuan GuoThis book – a collection of reviews and research articles by the top academics in the field – provides a glimpse of the cutting-edge technology and research being carried out and shows how researchers are utilizing this knowledge to develop new areas of study and novel applications. It serves as a valuable resource while exploring the latest advances in virus particle assembly and demonstrating how the knowledge of fundamental processes has been used to advance bio-nanotechnology. Chapters detail biophysical approaches and biomotor research, discus the latest advances in DNA/RNA nanoparticle assembly and use, and introduce the use of DNA/RNA nanoparticles for drug delivery.
Biomotors: Linear, Rotation, and Revolution Motion Mechanisms
by Peixuan Guo and Zhengyi ZhaoThis book provides a comprehensive overview of biomotors (molecular motors) within the body with a specific concentration on revolving molecular motors. The bioengineering of these new revolving molecular motors will go a long way in creating machines that will be able to carry RNA and DNA drugs directly to diseased cells to destroy them. The book goes into specific details regarding the bioengineering, fabrication, synthesis, and future utilization of these devices for nanomedicine.
Biomphalaria Snails and Larval Trematodes
by Rafael Toledo Bernard FriedThe purpose of this book is to provide an overview of the biology of the planorbid snail Biomphalaria glabrata mainly as related to the snail's role as a host of larval trematodes . This snail is of great importance in medical and economic zoology as a vector of important trematode (fluke) diseases in human and veterinary medicine and in wildlife biology. Moreover, this snail is a useful model for numerous basic studies in biology and chemistry. A book that provides modern coverage of diverse topics from the molecule to the community of this snail as related to larval trematode parasitism is not available. This book should appeal to a wide audience of biologists, ecologists, biochemists, malacologists, parasitologists, public health workers, epidemiologists, and graduate and advanced undergraduate students in biomedical and allied health sciences.
Biomythography Bayou (The Griot Project Book Series)
by Mel Michelle LewisWhen your stories flow from the brackish waters of the Gulf South, where the land and water merge, your narratives cannot be contained or constrained by the Eurocentric conventions of autobiography. When your story is rooted in the histories of your West African, Creek, and Creole ancestors, as well as your Black, feminist, and queer communities, you must create a biomythography that transcends linear time and extends beyond the pages of a book. Biomythography Bayou is more than just a book of memoir; it is a ritual for conjuring queer embodied knowledges and decolonial perspectives. Blending a rich gumbo of genres—from ingredients such as praise songs, folk tales, recipes, incantations, and invocations—it also includes a multimedia component, with “bayou tableau” images and audio recording links. Inspired by such writers as Audre Lorde, Zora Neale Hurston, and Octavia Butler, Mel Michelle Lewis draws from the well of her ancestors in order to chart a course toward healing Afrofutures. Showcasing the nature, folklore, dialect, foodways, music, and art of the Gulf’s coastal communities, Lewis finds poetic ways to celebrate their power and wisdom.
Bion Today: Bion Today (The New Library of Psychoanalysis)
by Chris MawsonBion Today explores how Bion’s work is used in contemporary settings; how his ideas have been applied at the level of the individual, the group and the organisation; and which phenomena have been made more comprehensible through the lenses of his concepts. The book introduces distinctive psychoanalytic contributions to show the ways in which distinguished analysts have explored and developed the ideas of Wilfred Bion. Drawing on the contributors’ experience of using Bion’s ideas in clinical work, topics include: an introduction to Bion clarification of the inter-related concepts of countertransference and enactment concepts integrating group and individual phenomena clinical implications of Bion’s thought Bion’s approach to psychoanalysis. Bion Today will be a valuable resource for psychoanalysts, psychotherapists and all those who are interested in learning more about Bion’s thinking and his work.
Bion and Being: Passion and the Creative Mind
by Annie ReinerWith his concept of "O," Wilfred Bion provided a new psychoanalytic space in which to explore the mind. Dr Annie Reiner's new book, Bion and Being: Passion and the Creative Mind, examines the similarities between this psychoanalytic space and the artist's creative sensibility, as well as mystical and religious states. This most mysterious and revolutionary of Bion's analytic ideas reflects what is essentially a state of being, an experience of mental integrity and union between emotional and rational functions of the mind which is the basis of thinking and creativity. In an effort to provide emotional understanding to Bion's theoretical ideas, Dr Reiner uses examples of artists, poets, writers, theologians, and philosophers, including Rilke, Cummings, Shakespeare, Beckett, and Nietzsche, to illustrate these psychoanalytic concepts. She also presents detailed clinical examples of patient's dreams to explore the obstacles to these states of being, as well as how to work clinically to develop access to these creative states.
Bion and Contemporary Psychoanalysis: Reading A Memoir of the Future
by Giuseppe CivitareseThis book examines the importance and continued relevance of A Memoir of the Future in understanding and applying Bion’s work to contemporary psychoanalysis. Bion continued to innovate throughout his life, but the Memoir has been largely overlooked. Focusing on A Memoir of the Future is not only of deep interest in terms of the author’s biography, or even only in function of a better understanding of his theoretical concepts, but can also be considered, for all intents and purposes, the final chapter of an ingenious creative enterprise While by some it was thought as the evidence of Bion’s presumed senility, this book challenges that perspective, arguing that it represents the last challenge he issued to the psychoanalytic Establishment. In each chapter, the authors explore this notion that A Memoir forms an essential part of Bion’s theory, and that in it he establishes a new ‘aesthetic’ psychoanalytic paradigm. With an international list of distinguished authors, this is a key book for any analysts interested in a comprehensive understanding of Bion’s work.
Bion and Intuition in the Clinical Setting (The Routledge Wilfred R. Bion Studies Book Series)
by Antònia GrimaltBion and Intuition in the Clinical Setting focuses on Bion’s investigation of the intuitive approach to clinical data and lays out how Bion’s method encouraged constant effort by the analysts to relinquish its reliance on sensory and conceptual-verbal faculties to make room for intuition. Based on the work of the biannual Bion conference, this book includes contributions from the most eminent voices on Bion’s work. Spanning topics such as the primordial mind, intuitive comprehension and desire, the contributors in this volume illustrate how they incorporate the concept of intuition in their own clinical developments. Each chapter examines different elements of how Bion’s research approaches the difficulties faced by analysts in the approach and discrimination of primitive emotional levels in the patient-analyst communication. This book will be of key interest to analysts and analytic therapists of all schools and is an essential resource for those that follow the work of Bion.
Bion and Meltzer's Expeditions into Unmapped Mental Life: Beyond the Spectrum in Psychoanalysis (Psychoanalytic Field Theory Book Series)
by Avner BergsteinDrawing on the influential contributions of Wilfred Bion and Donald Meltzer to psychoanalysis, Bion and Meltzer's Expeditions into Unmapped Mental Life explores and addresses the clinical implications of their work, both through revisiting several of their conceptions and illustrating them with detailed clinical material from the analyses of children, adolescents, and adults. Psychoanalysis strives towards truth; this is its essence. However, emotional truth is often unknowable and not amenable to verbal communication. This ineffable mental realm is at the heart of both Bion and Meltzer's psychoanalytic endeavours. Bion's writings reflect a developmental stage in the evolution of psychoanalysis, extending clinical work to mental realms that were seemingly unreachable. Donald Meltzer further infuses Bion's thinking with his own original notions of beauty and aesthetics, imbuing Bion's profound thinking with a poetic and lyrical tenor. Writing in a clear and lucid manner, Avner Bergstein integrates Bion's sometimes highly theoretical thinking with everyday clinical practice, facilitating his dense and condensed formulations and making them clinically accessible and useful. Bion and Meltzer's Expeditions into Unmapped Mental Life is written for psychoanalysts and psychoanalytically oriented psychotherapists who are attracted to Bion and Meltzer's radical thinking.
Bion and Primitive Mental States: Trauma and the Symbiotic Link (The Routledge Wilfred R. Bion Studies Book Series)
by Judy K. EekhoffThis clinically focused book explores W. R. Bion’s thinking on primitive and unrepresented mental states and shows how therapists can work effectively with traumatized patients who are difficult to reach. The author illuminates how trauma survivors suffer from direct access to primal undifferentiated positions of the psyche that lie outside the symbolic order of the mind and are resistant to treatment. This access, unmediated by symbolic representation but represented in the body, disrupts the normal trajectory of development and of relationship. Integrating theory and clinical application, the book addresses processes of symbolization, somatic receptivity, and the use of countertransference when working therapeutically with undeveloped areas of the mind. It also demonstrates how primitive body relations and object relations include the body of the analyst as part of the analytic frame and are essential in establishing a therapeutic alliance. Illustrated with detailed clinical vignettes, Bion and Primitive Mental States is important reading for psychoanalysts, psychologists, social workers, and educators who wish to understand primitive states of mind and body in patients who have previously been considered untreatable.
Bion and Thoughts Too Deep for Words: Psychoanalysis, Suggestion, and the Language of the Unconscious (The Routledge Wilfred R. Bion Studies Book Series)
by Robert CaperDistinguishing psychoanalysis, as a search for truth, from suggestion, as a cure for symptoms, this book addresses the scientific status of psychoanalysis. Citing research into the relationship of infants to their caretakers, the author discusses evidence that unconscious communication is present from birth, and that this form of communication plays a central role in psychoanalysis at a level below that of verbal communication.Informed by Bion's ideas of containment, group functioning and the fundamental psychological need for truth, this book asserts that psychoanalysis, based solely on the search for truth, has, among all psychological interventions, both a unique claim to scientific status and a unique ability to foster psychological development. Exploring the relationship between unconscious communication, group dynamics, containment and psychological development in a highly original way, Bion and Thoughts Too Deep for Words: Psychoanalysis, Suggestion, and the Language of the Unconscious will be of great interest to psychotherapists, psychologists and psychoanalysts who are interested in the relationship between psychoanalysis and suggestion.
Bion in Brazil: Supervisions and Commentaries
by Wilfred R. BionThe discovery, translation into English, and publication of these previously unpublished recordings of Bion's clinical supervisions in Sao Paulo, Brazil, with commentaries by leading Brazilian psychoanalysts, gives readers the opportunity to experience for themselves his clinical and theoretical thought as it emerges and evolves through a series of fascinating case discussions.
Bion in Buenos Aires: Seminars, Case Presentation and Supervision
by Wilfred R. BionThese newly discovered clinical seminars of Wilfred Bion, which include supervisions, personal case presentations, and lectures on psychoanalytic theory, represent his initial foray into many years of work that have inspired South American analysts for nearly a half a century.The clinical and theoretical work of Bion arguably ranks rather high in the current psychoanalytic firmament-as national and international conferences convene regularly to continue discussing the contemporary relevance of his work. His work has served as a source of inspiration to contemporary psychoanalysts in all three regions of the International Psychoanalytical Assocation-Ronald Britton, Antonino Ferro, Giuseppe Civitarese, Thomas Ogden, James Grotstein, and Paolo Sandler, just to name a few. These newly discovered clinical seminars from work Bion conducted in Buenos Aires in 1968 help us to further fill out the picture of his versatile gifts. In these seminars, we find lectures on Bion's elaborations on his epistemological research-still on-going in the 1960s when he went to Buenos Aires; a lecture on the Grid and its clinical relevance.
Bion in Film Theory and Analysis: The Retreat in Film
by Carla Ambrósio GarciaIn Bion in Film Theory and Analysis: The Retreat in Film, Carla Ambrósio Garcia introduces the rich potential of the thinking of British psychoanalyst Wilfred Bion for film theory. By so doing, she rethinks the space of the cinema as a space of retreat, and brings new insights into the representation of retreat in film. Presented in two parts, the book seeks to deepen our understanding of the film experience and psychical growth. Part I places Bion’s view on the importance of the epistemophilic instinct at the heart of a critique of the pleasure-centred theories of the cinematic apparatus of Jean-Louis Baudry, Christian Metz and Gaylyn Studlar, proposing an idea of cinema as ‘thoughts in search of a thinker’. Garcia then moves from Bion’s epistemological period to his later work, which draws on mysticism, in order to posit an emotional experience in the cinema through which the subject can be or become real (or at one with ‘O’). Part II examines representations of retreat in four European films, directed by Ingmar Bergman, Pier Paolo Pasolini, Georges Perec and Bernard Queysanne, and Manoel de Oliveira, showing them to articulate a gesture of retreat as an emotionally turbulent transitional stage in the development of the psyche – what Bion conceptualizes as caesura. Through its investigation of the retreat in cinema, the book challenges common understandings of retreat as a regressive movement by presenting it as a gesture and space that can also be future-oriented. Bion in Film Theory and Analysis will be of significant interest to academics and students of psychoanalysis, psychotherapy, and film and media studies, as well as psychoanalysts and psychotherapists.
Bion in the Consulting Room: An Implicit Method of Clinical Inquiry (The Routledge Wilfred R. Bion Studies Book Series)
by Nicola Abel-Hirsch Joseph Aguayo Sira Dermen R. HinshelwoodBion in the Consulting Room addresses the long-unanswered question of Bion’s clinical and supervisorial technique and examines the way Bion’s conceptual model and clinical practices informed his theoretical work.As Bion wrote about technique so rarely, the authors set about looking at many of his clinical and supervisorial examples to infer what might be learned from them. This book factors in the four distinctive periods of Bion's clinical and supervisorial work in chronological order: the group period of the 1940s; the period of the psychosis papers in the 1950s; the epistemological period of the early 1960s; and, finally, the period of his international group seminars in the late 1960s and 1970s. In all four periods, the authors examine and analyze his method of clinical inquiry, or how he went about knowing and experiencing his analysands and supervisees. The authors offer a uniquely overarching view of his method of clinical inquiry, uncovering an amazing consistency in how Bion went about his work both as a psychoanalyst and supervisor.This illuminating book is essential reading for psychoanalysts, psychotherapists, and psychologists interested in the work of Wilfred Bion and the importance of his legacy in contemporary practice.
Bion's Dream: A Reading of the Autobiographies
by Meg Harris Williams'This book offers a definitive reading of Bion's remarkable autobiographical writings from a perspective embedded in the poetry of the ages, that of the Romantics in particular. It is at once learned and, utterly freshly, able to explore the inside story of Bion's life and mind. The volume is a distillation and elaboration of the work of many years. Whilst ostensibly an extended commentary on the autobiographical works themselves, it is also, in its own right, a tour de force, engaging, as it does, with the heart of the matter: with the development of a psychoanalyst, of a life, a self, a mind, thoroughly inward with the "dark and sombre world of thought".'- Margot Waddell, psychoanalyst and consultant child psychotherapist, Tavistock Clinic
Bion's Legacy to Groups
by David Armstrong Franco Borgogno Parthenope Bion Talamo Silvio A. Merciai'It is characteristic of some forms of scientific genius to alter not just what we see in the world, but how we see it - not just the view, but the lens. One thinks of Freud's discovery of the transference, or of Melanie Klein's attention to the play of children. Wilfred Bion's study of groups and group processes also has this quality. More than the content of what he saw and captured in the concepts of two modes of mental functioning in groups and in the differentiation of the basic assumptions, it was the way he saw or, more broadly, the way he sensed the emotional life of the individual in the group, and in the first instance his own, that opened up a quite new territory for exploration. Those of us whose practice takes place primarily in the institutional or social domain can find in his more psychoanalytic work seeds of new thought extending beyond the consulting room.Going "beyond the confines" might perhaps more generally stand as a metaphor for Bion's enterprise.
Bion's Legacy: Bibliography of Primary and Secondary Sources of the Life, Work and Ideas of Wilfred Ruprecht Bion
by Harry KarnacThis book forms a comprehensive bibliography of the works of W. R. Bion, and the other works that made some bearing of his life and thought. It discusses Bion's contribution to various disciplines beyond the psychoanalytic and psychotherapeutic.
Bion's Sources: The shaping of his paradigms
by R. D. Hinshelwood Nuno TorresThere are an increasing number of publications concerned with the work of Wilfred Bion (1897-1979). Many have sought new ideas from his writing however, little attention has been paid to the intellectual context in which Bion wrote. Bion’s Sources traces where Bion’s new ideas came from, what job he required of them, how successfully he used his context and how that has fertilised psychoanalysis. Expert contributors provide chapters on areas of the intellectual context separate from or adjacent to clinical psychoanalysis in Britain which have clearly influenced the texts Bion left (those published in his life time, or subsequently). Chapters explore the influences deriving from Wilfred Trotter, Henri Bergson and process philosophy, Kurt Lewin and group dynamics, Immanuel Kant, R. B. Braithwaite and the philosophy of science, the mathematics of notation and transformation, as well as the work of psychoanalysts who have applied their theories to social science, psychosomatics, and literature and the humanities. By contextualising Bion in the wider culture of ideas, and removing him from the exclusive world of Psychoanalysis, Bion’s Sources aims to moderate his ‘genius’ by showing how it was shaped by very wide influences. This book will be of interest to psychoanalysts, clinicians and those interested in the history of psychoanalytic ideas.
Bion's Transformations Revisited and Expanded: Essays on the Complexity of Psychoanalysis (The Routledge Wilfred R. Bion Studies Book Series)
by Arnaldo ChusterIn this illuminating volume, Arnaldo Chuster provides a thorough critique of Wilfred Bion's seminal 1965 work, Transformations. Offering a rich and nuanced opportunity to enhance one's understanding of this pivotal psychoanalytic text, Chuster establishes a link between the practice of psychoanalysis and Bion's advanced theory, including the key challenges he encountered in the clinical setting with patients. Working through Transformations, Chuster embarks on a courageous journey to follow Bion's path in creating a dialogue between multiple disciplines, explicating and expanding upon the core concepts of different types of transformation. Chuster recognizes Transformations as a pivotal point in Bion's publications, highlighting the profound manifestations of complex thinking it exhibits. Following the complexities of Bion's ideas, the book offers invaluable insights and expansions on topics such as ethics, aesthetics, and their application in imaginative conjectures, while also providing a rigorous discussion on the scientific foundations of Bion's work. Chuster's innovative perspectives and dedication to the work of Bion make this book a must-read for all psychoanalysts interested in demystifying the often convoluted work of this most eminent analyst and bringing his insightful theories into the 21st century.
Bion, Intuition and the Expansion of Psychoanalytic Theory (The Routledge Wilfred R. Bion Studies Book Series)
by Antònia GrimaltBion, Intuition and the Expansion of Psychoanalytic Theory illuminates how Bion’s work on intuition has changed the landscape of contemporary psychoanalysis through his understanding of its supra-scientific and non-sub-scientific condition. Based on the work of the biannual Bion conference, this book includes contributions from the most eminent voices on Bion’s work. The global cohort of contributors in this volume examine topics such as dream work, the Infinite Unconscious, the Spectral model of the mind, the realm of the minus and observation and intuition. Each chapter explores different elements arising from Bion’s insistence on learning from experience and establishing the difference between knowing and becoming as an experiential process of the mind as a container in relation to its contents of sensations, feelings, dreams and thoughts. This book will be of key interest to analysts and analytic therapists of all schools and is an essential resource for those that follow the work of Bion.