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Proteomic Methods in Neuropsychiatric Research
by Paul C. GuestDue to continuous technical developments and new insights into the high complexity of neurological diseases, there is an increasing need for the application of proteomic technologies which can yield potential biomarker readouts for improved clinical management as well as for the development of new drugs by struggling pharmaceutical companies. This book describes the step-by-step use of proteomic methods such as two-dimensional gel electrophoresis, multiplex immunoassay, liquid chromatography mass spectrometry (LC-MS) and selective reaction monitoring MS, to increase our understanding of these diseases, with the ultimate aim of improving patient care. The volume will be of high interest to clinical scientists, physicians and pharmaceutical company scientists as it gives insights into the latest technologies enabling the revolution of personalized medicine. It is of direct interest to both technical and bench biomarker scientists as it gives step by step instructions on how to carry out each of the protocols. It is also of interest to researchers as each technique will be presented in the context of a specific neurological disorder, including Alzheimer's disease, multiple sclerosis, autism spectrum disorders, schizophrenia, major depressive disorder and bipolar disorder. Finally, it will also highlight the future research efforts in this field, which are endeavoring to convert proteomic platforms to the form of hand held devices which can be used in a point of care setting and return diagnostic results within the timeframe of a visit to the general practitioner.
Proteomic and Ionomic Study for Identification of Biomarkers in Biological Fluid Samples of Patients with Psychiatric Disorders and Healthy Individuals (Springer Theses)
by Jemmyson Romário de JesusThis book presents an exploratory analysis based on proteomic and ionomics studies comparing the blood serum of patients with bipolar disorder (BD), healthy controls, patients with schizophrenia (SCZ), and patients with other disorders (OD) in order to identify biomarkers of BD. Bipolar disorder is a psychiatric condition that affects thousands of people worldwide. The absence of biomarkers for BD has resulted in misdiagnosis and ineffective treatment in some patients, causing additional health problems and high costs for health systems. As such, this book evaluates various strategies for sample preparation for proteomic and ionomic studies in order to simplify complex serum samples and allow the quantification of chemical species (proteins and metal ions), which are potential candidates for BD biomarkers. In addition, it describes the development of a new membrane-based methodology for extracting urine proteins to be used in biomarker discovery.
Protest and the Politics of Blame: The Russian Response to Unpaid Wages
by Debra JavelineThe wage arrears crisis has been one of the biggest problems facing contemporary Russia. At its peak, it has involved some $10 billion worth of unpaid wages and has affected approximately 70 percent of the workforce. Yet public protest in the country has been rather limited. The relative passivity of most Russians in the face of such desperate circumstances is a puzzle for students of both collective action and Russian politics. In Protest and the Politics of Blame, Debra Javeline shows that to understand the Russian public's reaction to wage delays, one must examine the ease or difficulty of attributing blame for the crisis. Previous studies have tried to explain the Russian response to economic hardship by focusing on the economic, organizational, psychological, cultural, and other obstacles that prevent Russians from acting collectively. Challenging the conventional wisdom by testing these alternative explanations with data from an original nationwide survey, Javeline finds that many of the alternative explanations come up short. Instead, she focuses on the need to specify blame among the dizzying number of culprits and potential problem solvers in the crisis, including Russia's central authorities, local authorities, and enterprise managers. Javeline shows that understanding causal relationships drives human behavior and that specificity in blame attribution for a problem influences whether people address that problem through protest. Debra Javeline is Assistant Professor of Political Science, Rice University.
Protestant Identity and Peace in Northern Ireland
by Graham SpencerWhat role can and do Protestant churches play in the development of peace and stability in Northern Ireland? Drawing from interviews with a wide range of Protestant clergy, this book examines how identity impacts on the Protestant imagination and relates that identity to the possibility of peace. Using history and theology as a context for understanding the principles and values on which Protestantism is built, clergy talk about how those values and principles shape different Church attitudes towards forgiveness and reconciliation. Placing these comments alongside Catholic interviews, to demonstrate differences in Christian emphasis and conviction, the book moves towards a consideration of how positive relations between opposing communities might take shape and recommends a new outlook based on inclusive rather than exclusive narratives.
Prothesenversorgung und Rehabilitation nach Amputation und bei angeborener Fehlbildung
by Susanne Breier Merkur AlimusajDieses Praxisbuch beschreibt die Herausforderungen, mit denen Erwachsene und Kinder nach einer Amputation oder bei angeborenen Fehlbildungen der unteren oder oberen Extremität konfrontiert sind. Unterschiedliche ganzheitliche Therapieansätze zeigen auf, wie Betroffene in ihrer Handlungsfähigkeit und sozialen Teilhabe unterstützt werden können, um größtmögliche Mobilität und Unabhängigkeit zu erreichen. Alle an der Rehabilitation beteiligten Berufsgruppen finden hier den aktuellen Stand der Prothesenversorgung; auch für Betroffene und deren Angehörige geeignet.Aus dem Inhalt: Grundlagen zu beruflicher und sozialer Rehabilitation, Amputationsformen, angeborene Fehlbildungen, Versorgung mit Orthoprothesen oder Prothesen operative und therapeutische Maßnahmen, Emotionale Auswirkungen einer Amputation und mögliche Bewältigungsstrategien, Assessmentinstrumente und Möglichkeiten der Versorgungsevaluation, Besondere Herausforderungen wie Mehrfachamputationen, Phantomgefühl und prothetisches Embodiment. Plus: Videos zu interaktivem Training, u.a. mit Prothese und Therapiebögen zum Download
Protocol Analysis: Verbal Reports as Data
by K. Anders Ericsson Herbert A. SimonVerbal data has been used increasingly to study cognitive processes in many areas of psychology, and concurrent and retrospective verbal reports are now generally accepted as important sources of data on subjects' cognitive processes in specific tasks.
Proust and the Squid: The Story and Science of the Reading Brain
by Maryanne WolfMany scholars believe that humans are hard-wired for language, but no one, points out Wolf (child development, Tufts U.), believes that about reading and writing. The act of reading is not natural, she argues, either for a child or in the evolution of the brain's capacity to learn. She loves it anyway, and here shares her knowledge and joy at learning to read in both evolutionary and development contexts; she also explores reasons that some people cannot learn to read. By the way, Proust says they were just friends; the squid is not commenting.
Providing Affirming Care to Transgender and Gender-Diverse Youth (SpringerBriefs in Public Health)
by Adam W. Dell Jessica Robnett Dana N. Johns Emily M. Graham Cori A. Agarwal Lindsey Imber Nicole L. MihalopoulosThis book aids clinicians in supporting and caring for transgender and gender-diverse children and adolescents – youth who are born into an incongruent body. A recent study using data from 19 states reported that 1.8% of American youth identified as transgender. Many people who are transgender will experience gender dysphoria, the intense emotional distress that is caused by a discrepancy between a person's gender identity and their sex assigned at birth. In this compact volume, the authors discuss the variety of domains involved in addressing gender dysmorphia: social, psychological, medical, and legislative/advocacy. They provide clear and concise information on the types and timing of gender-affirming medications and surgical interventions and offer useful suggestions for making interactions in the clinic and the clinical space inclusive for transgender and gender-diverse youth. Among the topics covered include:identity development and gender nonconformity in early childhood and pubertythe importance of access to mental health professionals with expertise in gender nonconformitythe responsible use of developmentally appropriate gender-affirming medications and surgical interventionsrelated clinical issues such as nutrition counselling for youth receiving gender-affirming treatmentscreating a safe and inclusive healthcare environment for transgender and gender-diverse youthadvocating for transgender and gender-diverse patients by working with local and national policy makersProviding Affirming Care to Transgender and Gender-Diverse Youth is essential reading for pediatric healthcare professionals including physicians in pediatrics and family medicine, plastic surgeons, nurses, dietitians, psychiatrists, psychologists, social workers, and other practitioners. Students in these fields as well as policy makers also would find this a useful resource.
Providing Home Care for Older Adults: A Professional Guide for Mental Health Practitioners
by Danielle L. TerryA practical guide to providing home-based mental health services, Providing Home Care for Older Adults teaches readers how to handle the unique aspects of home-based care and apply and adapt evidence-based assessment and treatment within the home-based setting. Featuring contributions from experienced, board-certified home care psychologists, social workers, and psychiatrists, the book explains the multifaceted role of a home-based provider, offers concrete and practical considerations for working within the home, and highlights adaptations to specific evidence-based methods used in treating homebound older adults. Also covered are special topics related to hoarding, safety, capacity evaluations, caregivers, case management, and use of technology. Each chapter includes engaging case examples with practical tips that illustrate what it is like to work in this new and exciting frontier. Psychologists, counselors, and other mental health practitioners in home settings will be able to use this guide to provide effective home-based care to older adults.
Providing Mental Health Servies to Youth Where They Are: School and Community Based Approaches
by Mark D. Weist Harinder S. Ghuman Richard M. SarlesFirst Published in 2002. Routledge is an imprint of Taylor & Francis, an informa company.
Providing Mental Health Support to Probation: A European Perspective (Palgrave Studies in Risk, Crime and Society)
by Charlie BrookerThis short book provides a European-wide survey of mental health and probation. Drawing on a significant study, it explores the knowledge and attitudes to mental illness based on a sample of probation staff from 27 countries. It sets out the significance of mental health for probation staff and includes examples of good working practice, a pragmatic review of the literature and recommendations for further actions agreed by the Council of Europe. It seeks to improve the knowledge of probation staff about mental illness and outlines a future agenda for practice, service organisation and research.
Provision of Mental Health Counseling Services Under Tricare
by Institute of Medicine of the National AcademiesIn this book, the IOM makes recommendations for permitting independent practice for mental health counselors treating patients within TRICARE--the DOD's health care benefits program. This would change current policy, which requires all counselors to practice under a physician's supervision without regard to their education, training, licensure or experience.
Provocadores Del Pensamiento O Malos Sueños: Malos Sueños
by Jonathan FinchEl pensamiento nos lleva a todas partes y a ninguna. El pensamiento es un gran decisivo. Por el momento, el pensamiento es libre. Cuando se encuentre encadenado, también estaremos encadenados. Pero, paradójicamente, el pensamiento está condicionado y crece a partir de condiciones que no son libres. Por lo tanto, se debe argumentar que nuestros pensamientos están condicionados y libres. Todos disfrutan de una taza tranquila de té o café. ¿Por qué queremos ser desafiados desde la comodidad de nuestras tazas? Los provocadores del pensamiento son pequeños irritantes que nos hacen pensar. Si no nos gustan, aún tenemos que pensar en ellos para decidir por qué no nos gustan. Esta colección de ortigas mínimas está aquí para picar. Prepárate para ser picado y mira dónde colocas ese trasero tuyo. Ortigas, ortigas, ortigas, ¡y no se te permitirá que las conviertas en sopa agradable y saludable!
Proximity as Method: Concepts for Coexistence in the Global Past and Present (Transdisciplinary Souths)
by Riccarda Flemmer Bani Gill Jacky KosgeiThis book examines proximity as a benchmarked concept that can be deployed across a range of humanities disciplines to rethink the ways in which existences in the world are always already coexistences – and to parse the heuristic, ethical, epistemological, praxeological consequences of this recognition.The volume:- Brings together diverse theoretical approaches and utilizes a range of methodological instruments – conceptual, textual-analytic (whether in the realm of literary or religious studies, or theology or law), archival, digital, sociological or politological;- Includes empirical case-studies that allow calibrated and scaled exemplifications;- Launches forays onto unexplored conceptual terrain, or call into question hallowed truths of scholarly procedure.The volume will be essential reading for students and early researchers in the social sciences and the humanities.
Prozac Monologues: A Voice from the Edge
by Willa GoodfellowShe was going to stab her doctor, but she wrote a book instead.Years later, Willa Goodfellow revisits her account of the antidepressant-induced hypomania that hijacked her Costa Rican vacation and tells the rest of the story: her missed diagnosis of Bipolar 2, how she&’d been given the wrong medications, and finally, her process of recovery.Prozac Monologues is a book within a book—part memoir of misdiagnosis and part self-help guide about life on the bipolar spectrum. Through edgy and comedic essays, Goodfellow offers information about a mood disorder frequently mistaken for major depression as well as resources for recovery and further study. Plus, Costa Rica. · If your depression keeps coming back . . . · If your antidepressant side effects are dreadful . . . · If you are curious about the bipolar spectrum . . . · If you want ideas for recovery from mental illness . . . · If you care for somebody who might have more than depression . . . . . . This book is for you.
Prozac Nation: Young and Depressed in America
by Elizabeth WurtzelIn Prozac Nation, Wurtzel describes her harrowing battle with clinical depression before she was finally treated with Prozac. In a society plagued by divorce, economic instability, and AIDS, Wurtzel depicts the growing number of depressed and overmedicated people in America.
Prozac on the Couch: Prescribing Gender in the Era of Wonder Drugs
by Jonathan Michel MetzlPills replaced the couch; neuroscience took the place of talk therapy; and as psychoanalysis faded from the scene, so did the castrating mothers and hysteric spinsters of Freudian theory. Or so the story goes. In Prozac on the Couch, psychiatrist Jonathan Michel Metzl boldly challenges recent psychiatric history, showing that there's a lot of Dr. Freud encapsulated in late-twentieth-century psychotropic medications. Providing a cultural history of treatments for depression, anxiety, and other mental illnesses through a look at the professional and popular reception of three "wonder drugs"--Miltown, Valium, and Prozac--Metzl explains the surprising ways Freudian gender categories and popular gender roles have shaped understandings of these drugs. Prozac on the Couch traces the notion of "pills for everyday worries" from the 1950s to the early twenty-first century, through psychiatric and medical journals, popular magazine articles, pharmaceutical advertisements, and popular autobiographical "Prozac narratives. " Metzl shows how clinical and popular talk about these medications often reproduces all the cultural and social baggage associated with psychoanalytic paradigms--whether in a 1956 Cosmopolitan article about research into tranquilizers to "cure" frigid women; a 1970s American Journal of Psychiatry ad introducing Jan, a lesbian who "needs" Valium to find a man; or Peter Kramer's description of how his patient "Mrs. Prozac" meets her husband after beginning treatment. Prozac on the Couch locates the origins of psychiatry's "biological revolution" not in the Valiumania of the 1970s but in American popular culture of the 1950s. It was in the 1950s, Metzl points out, that traditional psychoanalysis had the most sway over the American imagination. As the number of Miltown prescriptions soared (reaching 35 million, or nearly one per second, in 1957), advertisements featuring uncertain brides and unfaithful wives miraculously cured by the "new" psychiatric medicines filled popular magazines. Metzl writes without nostalgia for the bygone days of Freudian psychoanalysis and without contempt for psychotropic drugs, which he himself regularly prescribes to his patients. What he urges is an increased self-awareness within the psychiatric community of the ways that Freudian ideas about gender are entangled in Prozac and each new generation of wonder drugs. He encourages, too, an understanding of how ideas about psychotropic medications have suffused popular culture and profoundly altered the relationship between doctors and patients.
Prozac: Questions and Answers
by Ronald R. FieveFeatured on the cover of "Newsweek" and "New York Magazine. ". . debated on television and radio, written about in daily newspapers, "Prozac has raised hopes and sparked controversies across the country. But how much do you really know about "Prozac, the alleged "miracle drug" that doctors worldwide have employed to help alleviate crippling clinical depression in their patients?The bestselling author of "Moodswing," Dr. Ronald R. Fieve is one of the nation's foremost experts on "Prozac and its uses. In a clear, concise and easy-to-use format, he provides detailed and authoritative answers to the most commonly asked questions about "Prozac. . . giving essential information to help make "informed" decisions on this complex, often confusing, prescription, and offering interpretation of the effects of "Prozac on personality as well as the dangers of prescribing "Prozac to "misdiagnosed" patients.
Prozak Diaries: Psychiatry and Generational Memory in Iran
by Orkideh BehrouzanProzak Diaries is an analysis of emerging psychiatric discourses in post-1980s Iran. It examines a cultural shift in how people interpret and express their feeling states, by adopting the language of psychiatry, and shows how experiences that were once articulated in the richly layered poetics of the Persian language became, by the 1990s, part of a clinical discourse on mood and affect. In asking how psychiatric dialect becomes a language of everyday, the book analyzes cultural forms created by this clinical discourse, exploring individual, professional, and generational cultures of medicalization in various sites from clinical encounters and psychiatric training, to intimate interviews, works of art and media, and Persian blogs. Through the lens of psychiatry, the book reveals how historical experiences are negotiated and how generations are formed. Orkideh Behrouzan traces the historical circumstances that prompted the development of psychiatric discourses in Iran and reveals the ways in which they both reflect and actively shape Iranians' cultural sensibilities. A physician and an anthropologist, she combines clinical and anthropological perspectives in order to investigate the gray areas between memory and everyday life, between individual symptoms and generational remembering. Prozak Diaries offers an exploration of language as experience. In interpreting clinical and generational narratives, Behrouzan writes not only a history of psychiatry in contemporary Iran, but a story of how stories are told.
Prozessbasierte Therapie bei körperdysmorpher Störung: Ein psychotherapeutisches Behandlungsmanual (Psychotherapie: Praxis)
by Ulrich Stangier Viktoria RitterDas Therapiemanual stellt 7 Module zur prozessbasierten Behandlung der körperdysmorphen Störung (KDS) im Einzelsetting vor – Adressaten sind psychologische und ärztliche Psychotherapeuten, Psychiater, psychosomatisch tätige Ärzte, Dermatologen, ästhetisch-plastische Chirurgen. Teil I des Buches gibt eine fundierte Einführung in Störungsbild, Ätiologie, Diagnostik, psychotherapeutische und medikamentöse Behandlung. Im Teil II wird praxisnah Schritt für Schritt die prozessbasierte Behandlung der KDS anhand evidenzbasierter Interventionen vorgestellt. Das Manual liefert wertvolle Anregungen, die die Behandlung der körperdysmorphen Störung individuell und sehr effektiv machen. Arbeitsblätter stehen im Buch und zum Download zur Verfügung. Aus dem Inhalt: Detaillierte Veranschaulichung prozessbasierter Interventionen – Veränderung von Aufmerksamkeits- und Wahrnehmungsprozessen, Vorstellungsbildern, autobiografischen Erinnerungen, Kognitionen, Grundüberzeugungen, frühen maladaptiven Schemata bei KDS – Zusatzmodule zu spezifischen Problembereichen (Wunsch nach ästhetisch-plastischer Chirurgie, Muskeldysmorphie, Skin Picking, Depression). Über das Autorenteam: PD Dr. Viktoria Ritter, wissenschaftliche Mitarbeiterin/Assistentin Goethe-Universität Frankfurt. Psychologische Psychotherapeutin, Verhaltenstherapie. Dozentin und Supervisorin in Aus- und Weiterbildung. Prof. Dr. Ulrich Stangier, Psychologischer Psychotherapeut. Lehrstuhlinhaber Klinische Psychologie und Psychotherapie Goethe-Universität Frankfurt. Leiter des Zentrums für Psychotherapie und des Ausbildungsprogramms für Psychologische Psychotherapie.
Prude: How the Sex-Obsessed Culture Damages Girls (and America, Too!)
by Carol Platt LiebauPolitical analyst and commentator Carol Platt Liebau takes a hard look at the pervasiveness of sex in today's culture and the havoc it wreaks on young people.
Przywództwo z Synercube: Dynamiczna kultura przywództwa w dążeniu do doskonałości
by Anatoly Zankovsky Christiane von der HeidenOpis teorii przywództwa Synercube z praktycznymi przykładami. W książce omówionych zostało 10 stylów przywódczych opartych na trzech wymiarach: ludzie, zadania i wartości. Czytelnik ma okazję poznać różne rodzaje interakcji zachodzących w środowisku organi-zacji oraz dowiedzieć się, jak dzięki sile organizacji i za pomocą dostępnych zasobów uzyskiwać doskonałe wyniki, budując tym samym trwałą kulturę organizacyjną. Teoria Sy-nercube jest przewodnikiem na drodze do zmian. Model Synercube odnosi się do szeregu efektów psychologicznych oraz behawioralnych. Wprowadzanie zmian w oparciu o model Synercube staje się skuteczne, a efekty trwałe. Menadżerowie zarówno małych, jak i dużych organizacji z pewnością skorzystają na lekturze tej książki.
Präsentismus
by Daniela Lohaus Wolfgang HabermannIst Präsentismus eines der teuersten und gefährlichsten Phänomene der Weltwirtschaft? Das Buch bietet erstmalig eine umfassende und strukturierte Darstellung von Präsentismus und erspart so mühevolle Recherchearbeit in verstreuten Publikationen. Wissenschaftlich Interessierte, Personalverantwortliche und Studierende profitieren von einer verständlichen Zusammenfassung der wichtigsten Forschungsergebnisse aus unterschiedlichen Kulturkreisen und für diverse Berufsgruppen. Die Autoren haben aus diesen Ergebnissen ein entscheidungsintegriertes Modell entwickelt, das erklärt, unter welchen Bedingungen es zu Präsentismus kommt.Sie erfahren, wie Präsentismus erfasst wird und wie die monetären und immateriellen Kosten eingegrenzt werden können. Lernen Sie, wie verbreitet Präsentismus ist, was Mitarbeiter dazu motiviert, welche Vorteile mit diesem Verhalten verbunden sein können und dass dafür Belastungen und Konsequenzen in Kauf genommen werden.Dazu bekommen Sie einen Überblick über Maßnahmen des Betrieblichen Gesundheitsmanagements (BGM) zur gesundheitlichen Prävention und zur Bekämpfung erkrankungsbedingter Beschwerden von Beschäftigten als Ursachen von Präsentismus und Absentismus. Das Buch ist für alle Fach- und Führungskräfte wie auch für Betriebsräte und präventiv tätige Professionals bestens geeignet.
Prävention 4.0: Analysen und Handlungsempfehlungen für eine produktive und gesunde Arbeit 4.0
by Oleg Cernavin Welf Schröter Sascha StowasserZiel des Buches ist es, Handlungsoptionen von menschengerechter Arbeitsgestaltung in der digitalen Transformation zu identifizieren. Um die Potenziale zu nutzen und die Arbeitsbedingungen im Zuge der Integration smarter Technologien in Arbeitsprozessen gesundheitsgerecht und produktiv zu gestalten, müssen alle Akteure sensibilisiert und handlungsfähig sein. Das Buch enthält zahlreiche Beispiele und praxisnahe Empfehlungen zur menschengerechten Gestaltung der intelligenten Vernetzung von Mensch, Maschine und Organisation.
Prüfungsangst und Lampenfieber
by Werner Metzig Martin SchusterWer kennt nicht das Herzklopfen vor einer Prüfung, einem Bewerbungsgespräch, einem Vortrag oder einem Auftritt vor Publikum? Die Autoren zeigen, mit welchen wissenschaftlich begründeten Methoden man sich auf diese Situationen effektiv vorbereiten kann, um Stress, Angst und Lampenfieber zu reduzieren. In der 4. Auflage wurde das Buch auf den aktuellen Stand der Wissenschaft gebracht und um weitere Fallbeispiele sowie eigene Untersuchungen der Autoren ergänzt.