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Clinical Toxinology in Australia, Europe, and Americas
by Carl-Wilhelm Vogel Steven A. Seifert Denise V. Tambourgi P. GopalakrishnakoneThis handbook addresses various topics on clinical toxinology such as the epidemiology and management of snake and insect bites in Australia and different countries in Europe and the Americas. Chapters will be written by experts currently working in the subspecialty, many of whom have first-hand experience in the relevant research fields. In virtually all the topics, appropriate illustrations are provided to simplify comprehension including tables, figures and pictures. Clinical toxinologic conditions are becoming increasingly frequent, more so than is generally recognized. The conditions comprise of clinical aspects such as the diagnosis, management, and prevention of snakebite envenoming, scorpion sting, mushroom toxins, plant toxins, and other natural toxins. Clinical toxinology also deals with the ecology, epidemiology, regional differences, and varieties of fauna accounting for different envenoming manifestations. This reference work, part of the Toxinology handbook series, is designed to keep readers abreast with new knowledge and experience in toxinology regionally and globally. Toxinologists, researchers, scientists, and experts in this field from various working areas considered it necessary to collect all the aspects of clinical toxinology in a single, handy handbook. This can be used by medical students, postgraduate students, general practitioners, specialists in internal medicine, critical care physicians, emergency physicians, and anesthetists worldwide.
Clinical Transfusion Medicine
by Joseph D. Sweeney Yvonne RizkThis handbook focuses on the fundamentals of clinical transfusion. Specific guidance on the management of different clinical situations is the objective in order to facilitate clinical decision making. This handbook fills a void between the minimal information in general textbooks of medicine, surgery, anesthesiology, etc. and the more detailed tex
Clinical Trial Simulations: Applications and Trends (AAPS Advances in the Pharmaceutical Sciences Series #1)
by Carl C. Peck Holly H. KimkoThis edition includes both updates and new uses and issues concerning CTS, along with case studies of how clinical trial simulations are being applied in various therapeutic and application areas. Importantly, the book expands on the utility of CTS for informing decisions during drug development and regulatory review. Each chapter author was selected on the basis of demonstrated expertise in state-of-the-art application of CTS. The target audience for this volume includes researchers and scientists who wish to consider use of simulations in the design, analysis, or regulatory review and guidance of clinical trials. This book does not embrace all aspects of trial design, nor is it intended as a complete recipe for using computers to design trials. Rather, it is an information source that enables the reader to gain understanding of essential background and knowledge for practical applications of simulation for clinical trial design and analysis. It is assumed that the reader has a working understanding of pharmacokinetics and pharmacodynamics, modeling, pharmacometric analyses, and/or the drug development and regulatory processes.
Clinical Trials of Drugs and Biopharmaceuticals
by Chi-Jen Lee Lucia H. Lee Christopher L. Wu Benjamin R. Lee Mei-Ling ChenThe pharmaceutical industry is on the verge of an exciting and challenging century. Advances in pharmaceutical sciences have dramatically changed the processes of discovery and development of new therapeutic drugs and, in turn, resulted in an extraordinary increase in the potential prophylactic and therapeutic interventions. In this atmosphere, an
Clinical Trials of Genetic Therapy with Antisense DNA and DNA Vectors
by Eric WickstromAn important new collection of clinical and preclinical reports on genetic therapy, this book describes illustrative examples of diseases in which gene-based interventions are presently plausible, and presents case studies of current research using both synthetic oligonucleotides and biological vectors. Combining the insights of over 50 contributors, Clinical Trials of Genetic Therapy with Antisense DNA and DNA Vectorsfurnishes a historical overview of genetic therapy highlights official Food and Drug Administration positions on the preparation of oligonucleotides and vectors offers practical models of agent preparation, animal testing, pharmacokinetics, toxicology, and clinical trials discusses both synthetic DNA and biological vector approaches to cancer, viral, and cardiological indications illustrates for new practitioners how each stage of genetic therapy is developed details genetic treatment of leukemia; lymphoma; cancer of the brain, breast, colon, kidney, and lung; melanoma; HIV; and coronary restenosis includes examples of antisense, ribozyme, tumor suppressor, immunostimulation, and gene replacement therapy and addresses questions of preparation, delivery, toxicity, mechanism, and specificity.
Clinical Trials Risk Management
by Martin Robinson Simon CookDrug development is risky business. It is against the backdrop of huge financial, scientific, technical and medical risks that a clinical trials manager is expected to function, effectively identifying and managing all project risks, to deliver a successful outcome. Focusing on the day-to-day needs of a clinical trials manager, Clinical Trials Risk
Clinical Vision Science: A Concise Guide to Numbers, Laws, and Formulas
by Gunnar SchmidtmannThis book provides a concise and user-friendly guide to the most common and important numbers, laws and formulas in clinical vision science. Clinicians and trainees in ophthalmology, optometry, orthoptics, and ophthalmic dispensing, who are seeking an easy-to-use lab coat pocket size resource, will find this book to be an essential reference in clinical practice. Clinical Vision Science: A Concise Guide to Numbers, Laws, and Formulas is clearly structured into basics, physical optics, visual optics and ophthalmic lenses, optical instruments, photometry, visual perception, clinical procedures, and anatomy & binocular vision. Each chapter contains a range of tables, formulas, large illustrations and flow charts to allow readers to quickly and accurately find key facts for each type of examination procedure.
Clinical Xenotransplantation: Pathways and Progress in the Transplantation of Organs and Tissues Between Species
by David K. C. Cooper Guerard ByrneThis title provides an illuminating examination of the current state of xenotransplantation – grafting or transplanting organs or tissues between members of different species – and how it might move forward into the clinic. To be sure, this is a critical topic, as a major problem that remains worldwide is an inadequate supply of organs from deceased human donors, severely limiting the number of organ transplants that can be performed each year. Based on presentations given at a major conference on xenotransplantation, this title includes important views from many leading experts who were invited to present their data and opinions on how xenotransplantation can advance into the clinic. Attention was concentrated on pig kidney and heart transplantation as it is in regard to these organs that most progress has been made. Collectively, these chapters effectively highlight the many advantages of xenotransplantation to patients with end-stage organ failure, thereby encouraging the mapping of a concrete pathway to clinical xenotransplantation. The book is organized across 22 chapters, beginning with background information on clinical and experimental xenotransplantation. Following this are discussions addressing how pigs can be genetically engineered for their organs to be resistant to the human immune response through deletion of pig xenoantigens, and the insertion of ‘protective’ human transgenes. Subsequent chapters analyze complications that arise in practice, comparing allotransplant and xenotransplant rejection. The selection of the ideal patients for the first clinical trials is discussed. Finally, the book concludes with an analysis on the regulatory, economic, and social aspects of this research, including FDA perspectives and the sensitive, psychosocial factors regarding allotransplantation and xenotransplantation. A major and timely addition to the literature, Clinical Xenotransplantation will be of great interest to all researchers, physicians, and academics from other disciplines with an interest in xenotransplantation.
The Clinician, the Brain, and 'I': Neuroscientific findings and the subjective self in clinical practice (Explorations in Mental Health)
by Tony SchneiderThe clinician needs to make sense of many client experiences in the course of daily practice: do these experiences reflect the simple product of complex neurochemical activity, or do they represent another dynamic involving the subjective self? When research findings from the neurosciences are applied to clinical psychology, reductionist thinking is typically followed, but this creates problems for the clinical practitioner. In this book Tony Schneider draws together the three strands of philosophy, neuroscience, and psychology to explore the mind/body question as it affects the clinician. Taking a position more closely aligned with dualism, he argues for the utility in making distinctions between brain activity and ‘I’ – the subjective self – both in general psychological functioning and in psychopathology. Schneider considers traditional psychological topics contextualized by neuroscience research and the mind/body issue, as well as applying the ideas to various areas of clinical practice. Topics include: -the mind and body from the clinician’s perspective -fundamental aspects of the role and mechanics of the brain -the developing self and the relationship of ‘I’ with the self and with others -psychological functioning such as focus and memory, sleep and dreaming, and emotions and pain. The idea that ‘I am not my brain’ will resonate with many clinicians, and is systematically argued for in clinical literature and neuropsychology research here for the first time. The book will be of particular interest to psychologists, psychiatrists, counsellors and clinicians who wish to incorporate advances in neuroscience research in the conceptualization of their clinical work, and are looking for a working model that allows them to do so.
Clinician's Guide to Diagnostic Imaging
by William R. ReinusThis book is a concise guide to ordering radiology tests for diagnosis and treatment and provides best practice guidelines for patients whose management depends on a clinical question that is best approached through imaging. Organized primarily by organ system, it outlines considerations in selecting the most efficacious imaging studies based on the clinical history, laboratory values, and physical findings to arrive cost-effectively at a correct diagnosis. It also explores the current limitations of each imaging modality and presents evidence-based information to insure that patient safety considerations are observed when ordering potentially dangerous examinations. Clinician's Guide to Diagnostic Imaging is a valuable resource for all physicians who regularly order imaging studies, including primary care physicians, family practitioners, internists, and surgeons alike. Further, this volume serves as an invaluable reference for medical students who are exposed to medical imaging for their first time or who are rotating through a radiology elective in medical school.
A Clinician’s Guide to Functional Neurological Disorder: A Practical Neuropsychological Approach
by Egberdina-Józefa van der HulstThis manual for clinicians presents a ground-breaking, accessible and unifying new model for understanding functional neurological disorder (FND) that bridges the gap between theoretical FND-specific models and the more practical, but non-FND-specific Cognitive Behavioural Therapy (CBT) models. Grounded in psychology, the Pressure Cooker Model provides a clear metaphor for FND, focusing on intra-individual and inter-individual cognitive, emotional and behavioural processes. Developed based on years of clinical experience in the field, it is applicable to the assessment and treatment of every type of FND. Viewed as a systemic condition with unique psychosocial features, the book will describe the rationale for radically transforming FND recovery by providing a treatment model that aims to resolve emotion dysregulation processes and repair relationships between the person and the system. It uses a unifying framework to guide the steps of intervention and can be adapted for work in a multidisciplinary team context to facilitate communication between disciplines. Enriched with case studies and research data, the book also highlights a plethora of clinical tools and strategies based on the Pressure Cooker Model, as well as contextualising its position alongside CBT models. This manual is instrumental in educating and treating people with FND. It offers essential guidance for neuropsychologists, neuropsychiatrists and other health professionals, as well as students in these fields.
Clinician's Guide To Neuropsychological Assessment
by Rodney D. VanderploegNeuropsychological assessment is a difficult and complicated process. Often, experienced clinicians as well as trainees and students gloss over fundamental problems or fail to consider potential sources of error. Since formal test data on the surface appear unambiguous and objective, they may fall into the habit of overemphasizing tests and their scores and underemphasizing all the factors that affect the validity, reliability, and interpretability of test data. But interpretation is far from straightforward, and a pragmatic application of assessment results requires attention to a multitude of issues. This long-awaited, updated, and greatly expanded second edition of the Clinician's Guide to Neuropsychological Assessment, like the first, focuses on the clinical practice of neuropsychology. Orienting readers to the entire multitude of issues, it guides them step by step through evaluation and helps them avoid common misconceptions, mistakes, and methodological pitfalls. It is divided into three sections: fundamental elements of the assessment process; special issues, settings, and populations; and new approaches and methodologies. The authors, all of whom are actively engaged in the clinical practice of neuropsychological assessment, as well as in teaching and research, do an outstanding job of integrating the academic and the practical. The Clinician's Guide to Neuropsychological Assessment, Second Edition will be welcomed as a text for graduate courses but also as an invaluable hands-on handbook for interns, postdoctoral fellows, and experienced neuropsychologists alike. No other book offers its combination of breadth across batteries and approaches, depth, and practicality.
A Clinician's Guide to Progressive Supranuclear Palsy
by Lawrence I. GolbeThis brief, clinically-focused volume is informed by Lawrence I. Golbe’s three decades of research and tertiary clinical care in progressive supranuclear palsy, a complex disorder with rapidly changing diagnostic and therapeutic approaches. It is an ideal source for the general neurologist seeking a refresher and the primary care provider, neurological nurse, or physical, occupational or speech therapist who must address their patients’ specialized needs. A Clinician’s Guide to Progressive Supranuclear Palsy emphasizes early diagnostic signs, medication options, non-pharmacologic management and palliative care. It offers a quick overview of the complications of PSP most likely to prompt an ER visit; a widening spectrum of PSP variants; and ample description of the genetics, epidemiology, natural history, pathology, molecular biology and neurochemistry of PSP. The PSP Rating Scale used in the book is a convenient tool for clinicians in routine practice and the leading PSP clinical measure world-wide. Golbe provides a practical and useful guidebook to help all clinicians learn and battle this complex disorder.
Clinicians in Court, Second Edition
by Allan E. BarskyInteracting with the legal system can be stressful and intimidating for mental health professionals. This trusted book provides user-friendly strategies to help clinicians prepare for testimony in court and other legal proceedings. Using vivid case scenarios from family law and other areas, the author explains legal terms and offers practical suggestions for avoiding pitfalls and managing ethical dilemmas. Clear guidelines are presented for record keeping, responding to subpoenas, preparing reports, and performing effectively on the stand as a fact witness or expert witness. Reproducible agreements and other sample documentation can be photocopied from the appendices or downloaded and printed in a convenient 8 1/2" x 11" size. New to This Edition Incorporates updates in research, case law, statutes, and practice. Examines the developing role of mental health professionals as forensic consultants. Increased attention to ethical issues, such as dual relationships, professional boundaries, confidentiality, and competence. An appendix with reflection questions that extend the scope of each chapter. Explores special issues that may arise in cases involving children Supplemental materials for course use-including an instructor's manual-are available at the author's website.
A Clinician's Pearls & Myths in Rheumatology
by John H. StoneImportant strides have been made in understanding the pathophysiologic basis of many inflammatory conditions in recent years, but rheumatology remains a discipline in which diagnosis is rooted in the medical history skillfully extracted from the patient, the careful physical examination, and the discriminating use of laboratory tests and imaging. Moreover, selection of the most appropriate therapy for patients with rheumatic diseases also remains heavily reliant upon clinical experience. Medical disciplines such as rheumatology that depend significantly upon clinical wisdom are prone to the development of systems of 'Pearls' and 'Myths,' related to the diseases they call their own, a 'Pearl' being a nugget of truth about the diagnosis or treatment of a particular disease that has been gained by dint of clinical experience and a 'Myth' being a commonly held belief that influences the practice of many clinicians - but is false. This book will pool together the clinical wisdom of seasoned, expert rheumatologists who participate in the care of patients with autoimmune diseases, systemic inflammatory disorders, and all other rheumatic conditions.
A Clinician's Pearls & Myths in Rheumatology
by John H. StoneThis book builds upon the first edition with new and improved chapters. The book explores the rich assemblage of clinical wisdom from expert rheumatologists from a wide range of specialties including Vasculitis and Sjogren’s syndrome. It examines the nuggets or ‘pearls’ of wisdom gained from collective clinical experience about the diagnosis or treatment of various diseases whilst also aiming to debunk myths that have influenced the practice of rheumatology by many clinicians. The second edition of A Clinician's Pearls and Myths in Rheumatology is a critical resource for both practitioners and students of rheumatology. This book provides a clear guide for those wishing to take a “deep dive” into the diagnostic and therapeutic elements of rheumatology.
The Clock Mirage: Our Myth of Measured Time
by Joseph MazurA tour of clocks throughout the centuries—from the sandglass to the telomere—to reveal the physical, biological, and social nature of time What is time? This question has fascinated philosophers, mathematicians, and scientists for thousands of years. Why does time seem to speed up with age? What is its connection with memory, anticipation, and sleep cycles? Award-winning author and mathematician Joseph Mazur provides an engaging exploration of how the understanding of time has evolved throughout human history and offers a compelling new vision, submitting that time lives within us. Our cells, he notes, have a temporal awareness, guided by environmental cues in sync with patterns of social interaction. Readers learn that, as a consequence of time&’s personal nature, a forty-eight-hour journey on the Space Shuttle can feel shorter than a six-hour trip on the Soyuz capsule, that the Amondawa of the Amazon do not have ages, and that time speeds up with fever and slows down when we feel in danger. With a narrative punctuated by personal stories of time&’s effects on truck drivers, Olympic racers, prisoners, and clockmakers, Mazur&’s journey is filled with fascinating insights into how our technologies, our bodies, and our attitudes can change our perceptions. Ultimately, time reveals itself as something that rides on the rhythms of our minds. The Clock Mirage presents an innovative perspective that will force us to rethink our relationship with time, and how best to use it.
The Clocks Are Telling Lies: Science, Society, and the Construction of Time
by Scott Alan JohnstonUntil the nineteenth century all time was local time. On foot or on horseback, it was impossible to travel fast enough to care that noon was a few minutes earlier or later from one town to the next. The invention of railways and telegraphs, however, created a newly interconnected world where suddenly the time differences between cities mattered.The Clocks Are Telling Lies is an exploration of why we tell time the way we do, demonstrating that organizing a new global time system was no simple task. Standard time, envisioned by railway engineers such as Sandford Fleming, clashed with universal time, promoted by astronomers. When both sides met in 1884 at the International Meridian Conference in Washington, DC, to debate the best way to organize time, disagreement abounded. If scientific and engineering experts could not agree, how would the public? Following some of the key players in the debate, Scott Johnston reveals how people dealt with the contradictions in global timekeeping in surprising ways – from zealots like Charles Piazzi Smyth, who campaigned for the Great Pyramid to serve as the prime meridian, to Maria Belville, who sold the time door to door in Victorian London, to Moraviantown and other Indigenous communities that used timekeeping to fight for autonomy.Drawing from a wide range of primary sources, The Clocks Are Telling Lies offers a thought-provoking narrative that centres people and politics, rather than technology, in the vibrant story of global time telling.
Clockwork Futures: The Science Of Steampunk And The Reinvention Of The Modern World
by Brandy SchillaceAirships and electric submarines, automatons and mesmerists?welcome to the wild world of steampunk. It is all speculative?or is it? Meet the intrepid souls who pushed Victorian technology to its limits and paved the way for our present age. The gear turns, the whistle blows, and the billows expand with electro-mechanical whirring. The shimmering halo of Victorian technology lures us with the stuff of dreams, of nostalgia, of alternate pasts and futures that entice with the suave of James Bond and the savvy of Sherlock Holmes. Fiction, surely. But what if the unusual gadgetry so often depicted as “steampunk” actually made an appearance in history? Zeppelins and steam-trains; arc-lights and magnetic rays: these fascinating (and sometimes doomed) inventions bounded from the tireless minds of unlikely heroes. Such men and women served no secret societies and fought no super-villains, but they did build engines, craft automatons, and engineer a future they hoped would run like clockwork. Along the way, however, these same inventors ushered in a contest between desire and dread. From Newton to Tesla, from candle and clockwork to the age of electricity and manufactured power, technology teetered between the bright dials of fantastic futures and the dark alleyways of industrial catastrophe. In the mesmerizing Clockwork Futures, Brandy Schillace reveals the science behind steampunk, which is every bit as extraordinary as what we might find in the work of Jules Verne, and sometimes, just as fearful. These stories spring from the scientific framework we have inherited. They shed light on how we pursue science, and how we grapple with our destiny—yesterday, today, and tomorrow.
Clone: The Road To Dolly, And The Path Ahead
by Gina KolataThe birth of Dolly -- the world's first clone -- placed in our hands the secret of creation. Few discoveries have so altered our notion of what it means to be human, or presented such a Gordian knot of ethical, spiritual, and scientific questions. Noted science journalist Gina Kolata broke the news nationally in The New York Times and was the first reporter to speak with Dr. Ian Wilmut, the embryologist who cloned Dolly. Now Kolata reveals the story behind Dolly, interweaving the social and cultural tales of our fear and fascination with cloning, reaching back nearly a century, with the riveting scientific accountof how a clone came to be and the mind-boggling questions Dolly presents for our future.Clone is a compelling blend of scientific suspense, dreams dashed, and frauds exposed, with provocative philosophical questions and an astute assessment of why Dolly's birth was only possible now. Like The Making of the Atomic Bomb, Lucy, and Chaos, this book gives us a window on history in the making, and an understanding of its profound effect on our lives.
The Clone Codes (The Clone Codes #1)
by Patricia C. Mckissack John Mckissack Fredrick L. MckissackThe Cyborg Wars are over and Earth has peacefully prospered for more than one hundred years. Yet sometimes history must repeat itself until humanity learns from its mistakes. In the year 2170, cyborgs and clones are treated no better than slaves, and an underground abolitionist movement is fighting for freedom. Thirteen-year-old Leanna's entire life is thrown into chaos when the World Federation discovers her mom is part of the radical Liberty Bell Movement. As startling family secrets are revealed, Leanna must face truths about self-identity and freedom. Through time travel, advanced technologies, and artificial intelligence, this exhilarating adventure asks what it means to be human and explores the sacrifices an entire society will make to find out.
The Clones (The Virtual War Chronolog #2)
by Gloria SkurzynskiCorgan now lives on the tropical Isle of Hiva, his reward for winning the Virtual War with his genetically altered teammates Sharla and Brig. Sharla visits him and tells him Brig died--but she has created clone-twins with Brig's DNA. Sharla and Corgan discover that while the clones look identical and are growing at a terrifying rate, they couldn't be more different in temperament.
Clones vs. Aliens (The Clone Chronicles #4)
by M. E. CastleFisher, Two, Amanda, and Veronica are happy to spend their holiday break at Fisher's parents' new amusement park. But when aliens crash-land on Fisher's favorite roller coaster, mistaking it for their home planet, it spells the end of R&R for our heroes. Meet the Gemini: not only are all the aliens identical twins, they're also all beautiful girls. The crew decides the best way to encourage the Gemini girls to vacate the stratosphere is to give them a taste of middle school. But Fisher and his crew learn quickly that the Geminis are not to be messed with, not when they might literally explode at any moment. That's right, the Geminis are like puberty times one million. They can seem sweet as pie, but when they turn on you, they're deadly.
Clones vs. Aliens: The Clone Chronicles #4
by M. E. CastleAliens join in the fun in this fourth book of The Clone Chronicles, a series that "strikes just the right balance between over-the-top adventure and real-life middle school drama," mixing Alex Rider, Diary of a Wimpy Kid, and Michael Buckley's NERD series to create an "action-packed success." Fisher, Two, Amanda, and Veronica are happy to spend their holiday break at Fisher's parents' new amusement park. But when aliens crash-land on Fisher's favorite roller coaster, mistaking it for their home planet, it spells the end of R&R for our heroes. Meet the Gemini: not only are all the aliens identical twins, they're also all beautiful girls. If Fisher and Two already thought girls were hard to understand, wait until they meet alien girls. Now Fisher, Two, Amanda, and Veronica must convince the aliens that Earth is the worst place ever and help them fix their ship. The crew decides the best way to encourage the Gemini girls to vacate the stratosphere is to give them a taste of middle school. And Wompalog Middle School tastes pretty disgusting. But Fisher and his crew learn quickly that the Geminis are not to be messed with, not when they might literally explode at any moment. That's right, the Geminis are like puberty times one million. They can seem sweet as pie, but when they turn on you, they're deadly.
Cloneward Bound (The Clone Chronicles #2)
by M. E. CastleThe second book in the hilarious middle-grade adventure series The Clone Chronicles. Fisher Bas and Two were able to thwart the evil Dr. X, but after somehow surviving the explosion at TechX Enterprises, Two is in Hollywood looking for his "mother." Fisher must bring him back to Palo Alto before his cloning secret is discovered. When a class field trip to see the Dr. Devilish science show arises, it becomes the perfect opportunity for Fisher to find his clone. But all kinds of complications will get in the way—including Amanda Cantrell, who knows more than Fisher would like about Two's identity. As Fisher, FP, and Amanda team up to find Two, they find trouble, hijinx, and the return of an evil mastermind—all set in the glitz of Hollywood.