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The Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race
by Walter IsaacsonThe bestselling author of Leonardo da Vinci and Steve Jobs returns with a gripping account of how the pioneering scientist Jennifer Doudna, along with her colleagues and rivals, launched a revolution that will allow us to cure diseases, fend off viruses, and enhance our children. In the spring of 2012, the Berkeley biochemist Jennifer Doudna and her collaborators turned a curiosity of nature into an invention that will transform the future of the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions. It has already been deployed to cure deadly diseases, fight the coronavirus pandemic of 2020, and make inheritable changes in the genes of babies. The development of CRISPR and the war against coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been an information-technology era, based on the microchip, the computer, and the internet. Now we are entering an even more momentous era, a life-science revolution. Children who study digital coding will be surpassed by those who study the code of life. Should we use our new evolution-hacking powers to make us less susceptible to viruses and eliminate dreaded disorders? What a wonderful boon that would be! Right? And what about preventing congenital deafness or blindness? Or being very short? Or being depressed? Hmmm…How should we think about that? Should we allow parents, if they can afford it, to enhance the IQ or height or memory or muscles of their kids? After helping to discover CRISPR, Doudna became a leader in wrestling with these moral and policy issues. Her life story illustrates that the key to innovation is connecting basic science to our everyday lives—moving discoveries from our labs to our bedsides—in ways that respect our moral values. It&’s a thrilling detective tale that involves the most profound wonders of nature, from the origins of life to the future of our species.
The Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race
by Walter IsaacsonThe bestselling author of Leonardo da Vinci and Steve Jobs returns with a gripping account of how Nobel Prize winner Jennifer Doudna and her colleagues launched a revolution that will allow us to cure diseases, fend off viruses, and have healthier babies. <P><P>When Jennifer Doudna was in sixth grade, she came home one day to find that her dad had left a paperback titled The Double Helix on her bed. She put it aside, thinking it was one of those detective tales she loved. When she read it on a rainy Saturday, she discovered she was right, in a way. As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would. <P><P>Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned a curiosity of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions. The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code. Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids? <P><P> After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020. Her story is a thrilling detective tale that involves the most profound wonders of nature, from the origins of life to the future of our species. <P><P><b>A New York Times Bestseller</b>
The Code Breaker -- Young Readers Edition: Jennifer Doudna and the Race to Understand Our Genetic Code
by Walter IsaacsonWalter Isaacson&’s #1 New York Times bestselling history of our third scientific revolution: CRISPR, gene editing, and the quest to understand the code of life itself, is now adapted for young readers!When Jennifer Doudna was a sixth grader in Hilo, Hawaii, she came home from school one afternoon and found a book on her bed. It was The Double Helix, James Watson&’s account of how he and Francis Crick had discovered the structure of DNA, the spiral-staircase molecule that carries the genetic instruction code for all forms of life. This book guided Jennifer Doudna to focus her studies not on DNA, but on what seemed to take a backseat in biochemistry: figuring out the structure of RNA, a closely related molecule that enables the genetic instructions coded in DNA to express themselves. Doudna became an expert in determining the shapes and structures of these RNA molecules—an expertise that led her to develop a revolutionary new technique that could edit human genes. Today gene-editing technologies such as CRISPR are already being used to eliminate simple genetic defects that cause disorders such as Tay-Sachs and sickle cell anemia. For now, however, Jennifer and her team are being deployed against our most immediate threat—the coronavirus—and you have just been given a front row seat to that war.
The Code Breaker -- Young Readers Edition: Jennifer Doudna and the Race to Understand Our Genetic Code
by Walter IsaacsonWalter Isaacson&’s #1 New York Times bestselling history of our third scientific revolution: CRISPR, gene editing, and the quest to understand the code of life itself, is now adapted for young readers! When Jennifer Doudna was a sixth grader in Hilo, Hawaii, she came home from school one afternoon and found a book on her bed. It was The Double Helix, James Watson&’s account of how he and Francis Crick had discovered the structure of DNA, the spiral-staircase molecule that carries the genetic instruction code for all forms of life. This book guided Jennifer Doudna to focus her studies not on DNA, but on what seemed to take a backseat in biochemistry: figuring out the structure of RNA, a closely related molecule that enables the genetic instructions coded in DNA to express themselves. Doudna became an expert in determining the shapes and structures of these RNA molecules —an expertise that led her to develop a revolutionary new technique that could edit human genes. Today gene-editing technologies such as CRISPR are already being used to eliminate simple genetic defects that cause disorders such as Tay-Sachs and sickle cell anemia. For now, however, Jennifer and her team are being deployed against our most immediate threat—the coronavirus—and you have just been given a front row seat to that war.
A Code for Carolyn: A Genomic Thriller (Science and Fiction)
by V. Anne SmithCarolyn’s parents did not, after all, make genomics history by synthesizing her genome in a lab. She has known she is the "Human Hoax" ever since a high school genetics exercise revealed she has trisomy X—a chromosomal abnormality—yet no synthetically constructed genome would have such clear traces of natural conception. Many years later, as molecular biologist, she hopes her colleagues never learn of her embarrassing origins. But when someone ransacks her office and lab, she finds professional embarrassment is the least of her worries. Someone believes she has the results of her parents’ last, secret experiments, and is willing to kill to get them. But all she has from her parents are their genes—can she find what else they may have left her before somebody else does? In a not-so-distant society, where corporations wield as much power as nations and the line between corporate employee and state authority is blurred, the chase is on. Carolyn may have just too little time at hand to unravel the mystery of her parents’ final days and to realize the deep consequences for the future of mankind. This fast-paced novel is followed by an extensive science chapter where the author provides a non-technical primer on modern genetics and on the speculative biology behind Carolyn’s code.
Code Girls: The Untold Story of the American Women Code Breakers of World War II
by Liza MundyThe award-winning New York Times bestseller about the American women who secretly served as codebreakers during World War II--a "prodigiously researched and engrossing" (New York Times) book that "shines a light on a hidden chapter of American history" (Denver Post).Recruited by the U.S. Army and Navy from small towns and elite colleges, more than ten thousand women served as codebreakers during World War II. While their brothers and boyfriends took up arms, these women moved to Washington and learned the meticulous work of code-breaking. Their efforts shortened the war, saved countless lives, and gave them access to careers previously denied to them. A strict vow of secrecy nearly erased their efforts from history; now, through dazzling research and interviews with surviving code girls, bestselling author Liza Mundy brings to life this riveting and vital story of American courage, service, and scientific accomplishment.
Code Like a Girl: Rad Tech Projects And Practical Tips
by Miriam PeskowitzWelcome to Code Like a Girl, where you'll get started on the adventure of coding with cool projects and step-by-step tips, from the co-author of the bestselling The Daring Book for Girls.Coding is about creativity, self-expression, and telling your story. It's solving problems and being curious, building things, making the world a better place, and creating a future. It's about you: whoever you are, wherever you're at, whatever you want. Nearly everything you encounter on a screen is made from code. You see, with code you can have an idea and put it into action: it's your voice and your vision. From the outside, tech and code may seem puzzling and mysterious, but when you get through the door and past the first few beginner steps and your code starts to work, it feels like magic. <P><P>In this book, you'll learn how to: <li> Code with Scratch <li> projects like making a dog walk through the park, sending your friend a card, and devising a full-scoring game! <li> Build your own computer--really! <li> Create your own digital fortune-teller, with the Python language. <li> Make your own smartphone gloves. <li> Make light-up bracelets. <li> Code a motion sensor that tells you when someone enters your room. <li> And lots more!
Coded Optical Imaging
by Jinyang LiangThis book provides a comprehensive survey of coded optical imaging. Illustrated with 386 figures, it takes readers from the fundamental concepts and theories to the latest research and applications in this field. It can be used in graduate-level courses in optics and photonics. It can also benefit scientists and engineers in optical imaging, computer graphics, and other related disciplines. This book starts from a brief history of coded optical imaging and key operations in its data acquisition and image reconstruction. It then presents the latest progress in technological development and applications in the areas of biomedicine, materials science, industrial inspection, optical physics, imaging science, information theory, and more. Chapters describe the most representative techniques, exposing readers to key research themes, including: · Optical signal encoding · Image reconstruction techniques · Compressed sensing · Artificial intelligence · Metasurface · Structured light · Lensless imaging · Holography · Tomography · Light-field imaging · Utrafast imaging · Hyperspectral imaging · Polarization imaging · Super-resolution imaging
Codes: How to Make Them and Break Them! (Murderous Maths Ser.)
by Kjartan Poskitt Ian BakerDid you ever want to send a message that only your friend can read? Or did you want to try and uncover a secret communication from someone else? If so, then here's everything you need to know about creating and cracking codes-from the simplest substitution messages to the secrets of the well-known World War II coding contraption, the amazing Enigma Machine!The book includes information about:Substitution codesScrambling codesCodes containing unrecognizable symbolsOther message systems such as Morse code and flagsAnd how to make your own Enigma machine!You’ll be thrilled as this amusing book takes you on a codebreaking adventure, learning ways to decode both simple and difficult puzzles, as well as provides you with a history on the cryptology. Filled with tips and enjoyable illustrations by Ian Baker, Codes will have you sending secret messages in no time.
Codes and Evolution: The Origin of Absolute Novelties (Biosemiotics #29)
by Marcello BarbieriThis text builds upon the over 1500 papers published in peer-reviewed journals revealing that there are more than 200 biological codes in living systems. The author claims this experimental fact is bound to change biology forever. This book shows how this very discovery reveals that coding is a new mechanism of life, just as the discovery of electromagnetism revealed the existence of a new physical force in the universe. The existence of many biological codes, furthermore, Barbieri argues, is one of those experimental facts that have extraordinary theoretical consequences. It implies that coding is not only a mechanism that constantly operates in all living systems, but also a mechanism of evolution, more precisely a mechanism that gave origin to the absolute novelties of the history of life. This amounts to saying that evolution took place by two distinct mechanisms, by natural selection and by natural conventions, two mechanisms that are fundamentally different because natural selection is the result of copying and deals with information whereas natural conventions are the result of coding and deal with meaning. This volume appeals to students and researchers working in the fields of semiotics, philosophy, biology and mathematics.
Codes of Ethics and Ethical Guidelines: Emerging Technologies, Changing Fields (The International Library of Ethics, Law and Technology #23)
by Michael Davis Elisabeth Hildt Kelly LaasThis book investigates how ethics generally precedes legal regulation, and looks at how changes in codes of ethics represent an unparalleled window into the research, innovation, and emerging technologies they seek to regulate. It provides case studies from the fields of engineering, science, medicine and social science showing how professional codes of ethics often predate regulation and help shape the ethical use of emerging technologies and professional practice. Changes in professional ethics are the crystallization of ongoing conversation in scientific and professional fields about how justice, privacy, safety and human rights should be realized in practice where the law is currently silent. This book is a significant addition to this area of practical and professional ethics and is of particular interest to practitioners, scholars, and students interested in the areas of practical and applied ethics.
El código de la vida: Jennifer Doudna, la edición genética y el futuro de la especie humana
by Walter IsaacsonWalter Isaacson vuelve a fascinarnos, esta vez con la historia de Jennifer Doudna, Premio Nobel de Química 2020, y el avance científico más importante del último siglo. Hay una revolución en marcha, una tecnología prodigiosa que nos va a permitir curar enfermedades, derrotar virus y tener hijos más sanos. A su cabeza está la reciente premio Nobel Jennifer Doudna y sus colegas, protagonistas del nuevo libro de Walter Isaacson. Aunque su profesor de instituto le advirtió que las niñas no podían ser científicas, su búsqueda apasionada de los mecanismos ocultos de la vida y su voluntad por convertir descubrimientos en inventos llevaron a Jennifer Doudna a participar en el avance más importante en el ámbito de la biología desde el descubrimiento de la doble hélice del ADN. Con su equipo, transformó una curiosidad de la naturaleza en una herramienta que cambiará el rumbo del ser humano. El CRISPR, una técnica fácil de usar que permite modificar el ADN, lo que abre un mundo nuevo de milagros médicos pero también de cuestiones morales. El desarrollo del CRISPR (y la carrera por encontrar la vacuna del coronavirus) acelerarán nuestra transición a la siguiente gran revolución. Los últimos cincuenta años han sido una era digital basada en el microchip, el ordenador e internet. Ahora comienza la revolución de las ciencias de la vida. A los estudiantes de código digital se les unirán los que estudian el código genético. ¿Deberíamos usar nuestras nuevas capacidades para hacernos menos vulnerables a los virus? ¿Y para prevenir la depresión? ¿Deberíamos aceptar que las familias que se lo puedan permitir mejoren la constitución física o la inteligencia de sus hijos? Tras dirigir el equipo que descubrió la tecnología CRISPR, Doudna ha liderado los debates en torno a estas cuestiones morales. Obtuvo, junto con su colaboradora Emmanuelle Charpentier, el Premio Nobel de Química en 2020. Su historia es una apasionante aventura que atraviesa las maravillas más profundas de la naturaleza, de los orígenes de la vida al futuro de nuestra especie. La crítica ha dicho...«El premio de este año tiene que ver con la idea de reescribir el código de la vida. Estas tijeras genéticas han llevado a la ciencia a una nueva era.»Anuncio del Premio Nobel de Química 2020 «Un libro extraordinario que profundiza en una de las tecnologías biológicas más innovadoras de nuestro tiempo y las personas que la crearon. Brillante es una lectura absolutamente necesaria para nuestra era.»Siddhartha Mukherjee «Un libro vital sobre la última gran innovación científica, y otra biografía de primer nivel de Isaacson.»Kirkus Weekly
Código genético
by Amàlia LafuenteMarina Fontcuberta, becaria posdoctoral, es la encargada de una línea de investigación sobre un fármaco contra el Alzheimer. Cuando llega un nuevo director al Instituto de Neurociencias, avalado por una carrera brillante en Estados Unidos, él apoya su trabajo con gran interés. Sin embargo, Marina descubrirá que las atenciones que le presta sobrepasan el terreno profesional y se verá obligada a tomar una decisión que podría poner toda su carrera en peligro.Amàlia Lafuente retrata con habilidad el mundo de la investigación científica: la rivalidad entre los becarios, el abuso de poder de los triunfadores, la competitividad, los juegos de seducción entre colegas de profesión...Con todos los ingredientes del mejor thriller, Código genético atrapa al lector con un tema de actualidad y unos personajes de carne y hueso.
El código maya: La aceleración del tiempo y el despertar de la conciencia mundial
by Barbara Hand ClowEl código maya constituye una profunda exploración de la manera en que, a medida que nos aproximamos al final del calendario maya, el tiempo y la conciencia se aceleran y nos proporcionan una nueva comprensión del universo. Valiéndose de las investigaciones de Carl Johan Calleman, y de las ideas de otros expertos en el calendario maya, Barbara Hand Clow examina 16 400 millones de años de evolución y descodifica las pautas creativas de la Tierra, o sea, la conciencia mundial. Estas grandes pautas culminan en 2011 y luego, durante 2012, importantes influencias astrológicas nos inspirarán a alcanzar la unidad y la iluminación. El código maya muestra cómo los ciclos temporales del calendario coinciden con períodos importantes en los bancos de datos evolutivos de la Tierra y la Galaxia de la Vía Láctea. Estas fases de la evolución convergen durante la etapa final del Calendario, el período comprendido entre 1999 y 2011. Tanto la guerra y la territorialidad como la gestión de los recursos y la separación de la naturaleza son parte de los acontecimientos cotidianos que debemos procesar durante estos escasos años: son prueba de la espiral del tiempo cada vez más compacta que estamos experimentando debido a la aceleración del tiempo. Barbara Hand Clow nos asegura que nuestra propia sanación personal es el factor más importante al prepararnos para dar este salto crítico en la evolución humana. Esto se ha dado en llamar “el despertar de la conciencia mundial”. Bestselling author Barbara Hand Clow shows how the Mayan Calendar is a bridge to galactic wisdom that fosters personal growth and human evolution • Unearths the meaning behind the calendar, its message for modern civilization, and what will happen when the calendar ends • Reveals how time acceleration is a manifestation of the acceleration of consciousness • By the author of The Pleiadian Agenda In this book, Barbara Hand Clow draws on the work of biologist Carl Johan Calleman and many other New Paradigm researchers to unearth the deeper meaning behind the Mayan Calendar and its message for modern civilization, especially during its final five years. As we approach the end of the calendar, time and consciousness are accelerating. Working with Calleman’s time-acceleration theory, Barbara Hand Clow shows how the cycles of time marked by the calendar match important periods in the evolutionary data banks of Earth and the Milky Way Galaxy and that the calendar describes the evolutionary stage to come. She explores how our own personal healing is the most important factor as we prepare to make this critical leap in human evolution--now referred to as the awakening of the World Mind.
Coding and Decoding of Calcium Signals in Plants (Signaling and Communication in Plants #10)
by Sheng LuanPlants cannot move away from their environments. As a result, all plants that have survived to date have evolved sophisticated signaling mechanisms that allow them to perceive, respond, and adapt to constantly changing environmental conditions. Among the many cellular processes that respond to environmental changes, elevation of calcium levels is by far the most universal messenger that matches primary signals to cellular responses. Yet it remains unclear how calcium, a simple cation, translates so many different signals into distinct responses - how is the "specificity" of signal-response coupling encoded within the calcium changes? This book will attempt to answer this question by describing the cellular and molecular mechanisms underlying the coding and decoding of calcium signals in plant cells.
Coding Architecture: Designing Toolkits, Workflows, Industry (Digital Innovations in Architecture, Engineering and Construction)
by Pierpaolo RutticoThis book provides a clear picture of how computational processes are gradually permeating and innovating the Architecture, Engineering, and Construction sector, contributing to sustainability and aesthetic evolution. It achieves that by gathering a collection of accounts shared by pioneering professionals involved in this innovation, drawing from recent academic studies, ongoing experimental processes conducted in cutting-edge architectural and engineering offices, as well as innovative industrial applications. The covered subjects span a wide range, including artificial intelligence and robotic manufacturing, the metaverse and 3D printing, strategies to counter CO2 consumption through plug-ins, as well as emerging materials and construction techniques. The chapters feature authors who are pioneers and embrace roles like software developers, architects, process engineers, academics, and forward-thinking entrepreneurs. They represent authoritative references within a broader interconnected cultural and technological system; an eclectic system that finds in computational processes the key to addressing the new challenges of contemporary architecture.
Coding Democracy: How Hackers Are Disrupting Power, Surveillance, and Authoritarianism (The\mit Press Ser.)
by Maureen WebbHackers as vital disruptors, inspiring a new wave of activism in which ordinary citizens take back democracy.Hackers have a bad reputation, as shady deployers of bots and destroyers of infrastructure. In Coding Democracy, Maureen Webb offers another view. Hackers, she argues, can be vital disruptors. Hacking is becoming a practice, an ethos, and a metaphor for a new wave of activism in which ordinary citizens are inventing new forms of distributed, decentralized democracy for a digital era. Confronted with concentrations of power, mass surveillance, and authoritarianism enabled by new technology, the hacking movement is trying to “build out” democracy into cyberspace.Webb travels to Berlin, where she visits the Chaos Communication Camp, a flagship event in the hacker world; to Silicon Valley, where she reports on the Apple-FBI case, the significance of Russian troll farms, and the hacking of tractor software by desperate farmers; to Barcelona, to meet the hacker group XNet, which has helped bring nearly 100 prominent Spanish bankers and politicians to justice for their role in the 2008 financial crisis; and to Harvard and MIT, to investigate the institutionalization of hacking. Webb describes an amazing array of hacker experiments that could dramatically change the current political economy. These ambitious hacks aim to displace such tech monoliths as Facebook and Amazon; enable worker cooperatives to kill platforms like Uber; give people control over their data; automate trust; and provide citizens a real say in governance, along with capacity to reach consensus. Coding Democracy is not just another optimistic declaration of technological utopianism; instead, it provides the tools for an urgently needed upgrade of democracy in the digital era.
Coding, Robotics, and Engineering for Young Students: A Tech Beginnings Curriculum (Grades Pre-K-2)
by Ann GadzikowskiCoding, Robotics, and Engineering for Young Students builds foundational computer science and robotics skills and knowledge in bright Pre-K-grade 2 students. Originally developed as enrichment courses for Northwestern University's Center for Talent Development, this curriculum emphasizes active, hands-on, and collaborative learning. Students are challenged to learn computer science content, such as coding, and robotics and engineering concepts, as well as practice high-level academic skills, such as creative problem solving, computational thinking, and critical thinking. Instructional practices balance screen time with active, collaborative classroom engagement. Learning is deepened when students are challenged to navigate the transition from a virtual learning environment to a tangible learning environment. The lessons can be implemented as standalone enrichment experiences or as part of a coordinated scope and sequence that leads to higher level computer science and engineering studies.Grades Pre-K-2
Coding Strategies in Vertebrate Acoustic Communication (Animal Signals and Communication #7)
by Thierry Aubin Nicolas MathevonInformation is a core concept in animal communication: individuals routinely produce, acquire, process and store information, which provides the basis for their social life. This book focuses on how animal acoustic signals code information and how this coding can be shaped by various environmental and social constraints. Taking birds and mammals, including humans, as models, the authors explore such topics as communication strategies for “public” and “private” signaling, static and dynamic signaling, the diversity of coded information and the way information is decoded by the receiver. The book appeals to a wide audience, ranging from bioacousticians, ethologists and ecologists to evolutionary biologists. Intended for students and researchers alike, it promotes the idea that Shannon and Weaver’s Mathematical Theory of Communication still represents a strong framework for understanding all aspects of the communication process, including its dynamic dimensions.
Coding Theory in Optical Wireless Communication Systems: Volume I (Optical Wireless Communication Theory and Technology)
by Xizheng KeThis book focuses on optical-wireless communication systems. It summarizes the author's optical-wireless communication coding work while carrying out pertinent scientific research programs. The primary topics covered in the book are channel coding, coding modulation, error control (channel coding), and channel equalization. The author's mathematical analysis and experimental studies on the key theoretical issues are discussed in the book. One of the book's outstanding aspects is its thorough and methodical discussion of practical optical-wireless communication challenges. This makes the book especially appealing to readers who are eager to learn about applicable solutions in this area. Researchers, engineers, and graduate students in the subject of telecommunications can all profit from the book. It is appropriate for senior undergraduates, lecturers at colleges and universities, graduate students, and engineering and technical workers involved in optical communication.
Coding Theory in Optical Wireless Communication Systems: Volume II (Optical Wireless Communication Theory and Technology)
by Xizheng KeThis book focuses on optical-wireless communication systems. It summarizes the author's optical-wireless communication coding work while carrying out pertinent scientific research programs. The primary topics covered in the book are channel coding, coding modulation, error control (channel coding), and channel equalization. The author's mathematical analysis and experimental studies on the key theoretical issues are discussed in the book. One of the book's outstanding aspects is its thorough and methodical discussion of practical optical-wireless communication challenges. This makes the book especially appealing to readers who are eager to learn about applicable solutions in this area. Researchers, engineers, and graduate students in the subject of telecommunications can all profit from the book. It is appropriate for senior undergraduates, lecturers at colleges and universities, graduate students, and engineering and technical workers involved in optical communication.
The Coen & Hamworthy Combustion Handbook: Fundamentals for Power, Marine & Industrial Applications (Industrial Combustion)
by Charles E. Baukal Stephen B. LondervilleThe rigorous treatment of combustion can be so complex that the kinetic variables, fluid turbulence factors, luminosity, and other factors cannot be defined well enough to find realistic solutions. Simplifying the processes, The Coen & Hamworthy Combustion Handbook provides practical guidance to help you make informed choices about fuels, burne
Coenzyme Q: Molecular Mechanisms in Health and Disease (Modern Nutrition)
by Valerian E. Kagan Peter J. QuinnSince its discovery in 1957, Coenzyme Q has piqued the interest of scientists from a wide range of disciplines because of its bioenergetics, vitamin-like behavior, and interactions with antioxidant vitamins E and C. Coenzyme Q: Molecular Mechanisms in Health and Disease is a comprehensive treatise on this often-studied coenzyme. International exper
Coenzyme Q in Aging
by Guillermo López LluchThis book offers a comprehensive exploration of research on the essential relationship of the coenzyme Q10 and the process of aging in living organisms. CoQ10 is an important factor in two main aspects of cell physiology: bioenergetics and antioxidant protection. While primary deficiency of CoQ10 is associated with severe and lethal disease, secondary deficiency can be associated with the progression of mitochondrial dysfunction linked to the lessening of biological activities during aging. The book is organized in four sections. The first offers an overview of the function of CoQ10, highlighting the two main functions of CoQ10 in cells: its essential role as electron transport chain member in mitochondria, and the protection of cell membranes against oxidation as one of the main endogenous-synthesized antioxidants. The second section covers research on Coenzyme 10. Topics include studies involving invertebrate models, mammal studies and the influence of CoQ on longevity. Also covered is research involving the role of CoQ in senescence-accelerated mice. Section three examines the effects of reduced CoQ in human aging, as evident in mitochondrial dysfunction, metabolic syndrome, neurodegenerative disorders, immunosenescence and fertility and reproduction. The final section, Prolongevity effectors and Coenzyme Q, explores research into slowing or stopping the aging process. Coverage includes strategies including calorie restriction, and modulation of CoQ10 levels by induction of synthesis or by supplementation. Coenzyme Q in Aging benefits a broad readership of researchers, clinicians, educators and students interested in the biochemical and physiological effects of coenzyme Q and the importance of this molecule in aging process.
Coercion, Survival, and War: Why Weak States Resist the United States
by Phil HaunIn asymmetric interstate conflicts, great powers have the capability to coerce weak states by threatening their survival--but not vice versa. It is therefore the great power that decides whether to escalate a conflict into a crisis by adopting a coercive strategy. In practice, however, the coercive strategies of the U. S. have frequently failed. In Coercion, Survival and War Phil Haun chronicles 30 asymmetric interstate crises involving the US from 1918 to 2003. The U. S. chose coercive strategies in 23 of these cases, but coercion failed half of the time: most often because the more powerful U. S. made demands that threatened the very survival of the weak state, causing it to resist as long as it had the means to do so. It is an unfortunate paradox Haun notes that, where the U. S. may prefer brute force to coercion, these power asymmetries may well lead it to first attempt coercive strategies that are expected to fail in order to justify the war it desires. He concludes that, when coercion is preferred to brute force there are clear limits as to what can be demanded. In such cases, he suggests, U. S. policymakers can improve the chances of success by matching appropriate threats to demands, by including other great powers in the coercive process, and by reducing a weak state leader's reputational costs by giving him or her face saving options.