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COVID-19: Origin, Detection and Impact Analysis Using Artificial Intelligence Computational Techniques
by Parag Verma Ankur Dumka Alaknanda Ashok Amit Dumka Anuj BhardwajThis book highlights progress in terms of Virus Biology and Infection Detection, Prevention, and Control, along with Screening, Testing, and Detection Techniques, that will provide learners and researchers (from basic to advanced) with the most innovative computer-driven methodologies for the fight against COVID-19. In addition, this book also covers the Pre- and Post-Impact of the COVID-19 Pandemic Crisis that will definitely provide useful content for researchers to think broadly about the analytical areas affected by COVID-19. This ultimately shows different paths to the same destination to help understand the nature of the COVID-19 pandemic and how to avoid it in the future.
COVID-19 and Emerging Environmental Trends: A Way Forward
by Joystu Dutta Srijan Goswami Abhijit MitraThe extensive safety restrictions imposed globally due to the COVID-19 pandemic have brought significant changes to almost all environmental parameters. The largest pandemic of the century has left an indelible mark on all aspects of human life and the environment. This book revolves around COVID-19 and its influence on all biotic and abiotic components on earth, with a focus on the regulatory role of air quality during the pandemic, environmental toxicity and susceptibility to COVID-19, and the impact of the lockdown on different ecosystems. The book fundamentally explains the biology of SARS-CoV-2 and the pathophysiology and epidemiology of COVID-19. Dedicated chapters highlight the ongoing global cutting-edge research on COVID-19, control and safety measures, and public health concerns. COVID-19 and Emerging Environmental Trends: A Way Forward is aimed at graduate and postgraduate students as well as researchers in environmental and medical science, health and safety, and ecology. This book offers a multiperspective and multidisciplinary approach to the discussion of the pandemic as well as emerging environmental issues, current trends, and a way forward. As humanity stands face-to-face with the largest global crisis in recent times, this book helps readers to easily understand its various aspects from a beginner’s perspective, without going into the intricate technicalities of medical science or environmental science, and beautifully juxtaposes critical issues with lucid language and flexible scientific explanations.
COVID-19 and SARS-CoV-2: The Science and Clinical Application of Conventional and Complementary Treatments
by Srijan Goswami and Chiranjeeb DeySince the end of December 2019, the world has been battling with a global health emergency called COVID-19. This ongoing pandemic has claimed millions of lives worldwide and made a serious impact on global healthcare. The information and facts about the virus and the pandemic are constantly evolving, expanding and are present in a scattered manner. Above all, various rumors and false information are also spreading through word of mouth or social media in relation to the pandemic. In situations like this, it becomes hard for a common person as well as professionals to keep track of the fundamental concepts, ongoing scientific advancements and differentiate between the facts and myths. COVID-19 and SARS-CoV-2: The Science and Clinical Application of Conventional and Complementary Treatments covers the fundamental concepts regarding SARS-CoV-2 and COVID–19 as well as common concerns and issues ensuring optimal understanding of the latest basic science and clinical content. The comparative coverage of Conventional Medical Science with Complementary and Alternative Systems of Medicine in relation to the ongoing pandemic makes this book unique compared to other books available on COVID-19. Written in textbook format and in semi-technical style, it provides basic to advanced concepts and multidimensional clinical perspectives keeping in mind the diverse needs of academicians, researchers, students and common people. Key Features: Contains simple, lucid and concise presentation of contents Emphasizes core knowledge and concepts Presents evidence based and up to date information from a multidisciplinary perspective Includes illustrations with good quality diagrams and colored photographs for ease of understanding. COVID-19 and SARS-CoV-2 covers concepts and protocols from holistic perspective relating to core Molecular Biology of SARS-CoV-2, Clinical and Therapeutic Aspects, Multidisciplinary Treatment and Management Strategies like Conventional Pharmacological Treatments, Vaccines, Ayurveda, Homoeopathy, Holistic Nutrition Therapy, Nutraceutical Therapy, Biochemic Medicine, and Issues and Concerns relating to Public Health and Ongoing Advances in Research in relation to COVID-19. Written in semi-technical language easily understandable by readers from all domains, this book provides multidisciplinary perspective, knowledge and understanding regarding COVID-19 in one place, thus bridging the knowledge gap that exists between Conventional Sciences and Complementary and Alternative Medicine Systems.
COVID 19, Containment, Life, Work and Restart: Regional Studies (Advances in 21st Century Human Settlements)
by T. M. Vinod KumarThis book is about containment, life, work, and restart regions affected by COVID 19, using selected empirical case studies. This book presents the spread of coronavirus spatially and temporally, analyses containment strategies and includes recommended strategies. Further, it analyses how life and work get transformed during the lockdown, and gradual opening up, and presents the future of work and life in cities impacted by COVID-19. This book discusses the concept of smart life and works in cities post-COVID-19 such that they do not reduce the quality of work and life and cannot create adverse economic and living consequences called the restart of a city after COVID-19.Selected Regions of special interest are studied. Special interest is because Kerala and Maharashtra got the worst affected in India by COVID 19 pandemic and the book focus on that.
COVID 19, Containment, Life, Work and Restart: Urban Studies (Advances in 21st Century Human Settlements)
by T. M. Vinod KumarThis book is about containment, life, work, and restart cities affected by COVID 19, using selected empirical case studies. This book presents the spread of coronavirus spatially and temporally, analyses containment strategies and includes recommended strategies. Further, it analyses how life and work get transformed during the lockdown, and gradual opening up, and presents the future of work and life in cities impacted by COVID-19. This book discusses the concept of smart life and works in cities post-COVID-19 such that they do not reduce the quality of work and life and cannot create adverse economic and living consequences called the restart of a city after COVID-19.Selected Cities of special interest are studied. Special interest is because Kerala and Maharashtra got the worst affected in India by COVID 19 pandemic and the book focus on that.
COVID-19 Epidemiology and Virus Dynamics: Nonlinear Physics and Mathematical Modeling (Understanding Complex Systems)
by Till D. FrankThis book addresses the COVID-19 pandemic from a quantitative perspective based on mathematical models and methods largely used in nonlinear physics. It aims to study COVID-19 epidemics in countries and SARS-CoV-2 infections in individuals from the nonlinear physics perspective and to model explicitly COVID-19 data observed in countries and virus load data observed in COVID-19 patients. The first part of this book provides a short technical introduction into amplitude spaces given by eigenvalues, eigenvectors, and amplitudes.In the second part of the book, mathematical models of epidemiology are introduced such as the SIR and SEIR models and applied to describe COVID-19 epidemics in various countries around the world. In the third part of the book, virus dynamics models are considered and applied to infections in COVID-19 patients. This book is written for researchers, modellers, and graduate students in physics and medicine, epidemiology and virology, biology, applied mathematics, and computer sciences. This book identifies the relevant mechanisms behind past COVID-19 outbreaks and in doing so can help efforts to stop future COVID-19 outbreaks and other epidemic outbreaks. Likewise, this book points out the physics underlying SARS-CoV-2 infections in patients and in doing so supports a physics perspective to address human immune reactions to SARS-CoV-2 infections and similar virus infections.
COVID-19 Experience in the Philippines: Response, Surveillance and Monitoring Using the FASSSTER Platform (Disaster Risk Reduction)
by Maria Regina Justina Estuar Elvira De Lara-TuprioThis book provides an overview of the extensive work that has been done on the design and implementation of the COVID-19 Philippines Local Government Unit Monitoring Platform, more commonly known as Feasibility Analysis of Syndromic Surveillance Using Spatio-Temporal Epidemiological Modeler for Early Detection of Diseases (FASSSTER). The project began in 2016 as a pilot study in developing a multidimensional approach in disease modeling requiring the development of an interoperable platform to accommodate input of data from various sources including electronic medical records, various disease surveillance systems, social media, online news, and weather data. In 2020, the FASSSTER platform was reconfigured for use in the COVID-19 pandemic. Using lessons learned from the previous design and implementation of the platform toward its full adoption by the Department of Health of the Philippines, this book narrates the story of FASSSTER in two main parts.Part I provides a historical perspective of the FASSSTER platform as a modeling and disease surveillance system for dengue, measles and typhoid, followed by the origins of the FASSSTER framework and how it was reconfigured for the management of COVID-19 information for the Philippines. Part I also explains the different technologies and system components of FASSSTER that paved the way to the operationalization of the FASSSTER model and allowed for seamless rendering of projections and analytics. Part II describes the FASSSTER analytics and models including the Susceptible-Exposed-Infected-Recovered (SEIR) model, the model for time-varying reproduction number, spatiotemporal models and contact tracing models, which became the basis for the imposition of restrictions in mobility translated into localized lockdowns.
COVID-19 in New York City: An Ecology of Race and Class Oppression (SpringerBriefs in Public Health)
by Rodrick Wallace Deborah WallaceThis book is the first social epidemiological study of COVID-19 spread in New York City (NYC), the primary epicenter of the United States. New York City spread COVID-19 throughout the United States. The context of epicenter formation determined the rapid, extreme rise of NYC case and mortality rates. Decades of public policies destructive of poor neighborhoods of color heavily determined the spread within the City. Premature mortality rates revealed the "weathering" of policy-targeted communities: accelerated aging due to chronic stress. COVID attacks the elderly more severely than those under the age of 60. Communities with high proportions of prematurely aged residents proved fertile ground for COVID illness and mortality. The very public policies that created swaths of white wealth across much of Manhattan and parts of Brooklyn destroyed the human diversity needed to ride out crises. Topics covered within the chapters include: Premature Death Rate Geography in New York City: Implications for COVID-19 NYC COVID Markers at the ZIP Code Level Prospero's New Castles: COVID Infection and Premature Mortality in the NY Metro Region Pandemic Firefighting vs. Pandemic Fire Prevention Conclusion: Scales of Time in Disasters An exemplary study in health disparities, COVID-19 in New York City: An Ecology of Race and Class Oppression is essential reading for social epidemiologists, public health researchers of health disparities, those in public service tasked with addressing these problems, and infectious disease scientists who focus on spread in human populations of new zoonotic diseases. The brief also should appeal to students in these fields, civil rights scholars, science writers, medical anthropologists and sociologists, medical and public health historians, public health economists, and public policy scientists.
COVID-19 in Zimbabwe: Trends, Dynamics and Implications in the Agricultural, Environmental and Water Sectors
by Lazarus Chapungu David Chikodzi Kaitano DubeThis contributed volume, based on papers presented at a conference held in Zimbabwe in mid-2021, interrogates solutions to COVID-19-related problems and issues across agricultural, environmental and water sectors in Zimbabwe and assesses their scientific, economic and practical validity. Across 19 chapters, this volume unpacks the science, economics and politics of the pandemic with a focus on understanding its secondary and tertiary impact on Zimbabwe’s population. The volume is also dedicated to understanding the practical and policy-oriented approaches in tackling the pandemic and confronting the “new normal” of COVID-19. It brings together researchers, development practitioners and policy makers from various disciplines in an endeavour to understand COVID-19 trends and analyse the scientific options for mitigation, containment, innovation and ultimately pre-empt the possible emergence and impacts of other pandemics in the future
COVID-19 Metabolomics and Diagnosis: Chemical Science for Prevention and Understanding Outbreaks of Infectious Diseases
by Frank N. CrespilhoThis book focus on COVID-19 topics, with emphasis on metabolomics and diagnosis. The chapters cover the chemical science for prevention and understanding outbreaks of infectious diseases. This book compiles the most widespread methodologies of application of quality statistical tools added to the evaluation of diagnostic tests for detection of SARS-CoV-2, metabolic behavior of COVID infection severity, and trends in rapid test for COVID-19.
Covid-19 Metabolomics and Diagnosis: Volume 2
by Frank N. CrespilhoThis book presents a collection of chapters on Covid-19 topics, with focus on the metabolomics and diagnosis. The chapters report on diagnostic tests for detection of SARC-CoV-2 virus and related proteins as well as post-Covid omics. This book covers Fourier-Transform Infrared spectroscopy and spectromicroscopy applied to Covid-19 studies and Carbon Nanomaterials as Covid-19 Electrochemical sensors. Moreover, the reader will find content on 3D printing for virus diagnosis, as well as organ-on-a-chip models for viral infection proteomics interaction.
COVID-19 Pandemic: Research and Development Activities from Modeling to Realization (Materials Horizons: From Nature to Nanomaterials)
by Balamati Choudhury Mamata Mohapatra Suddhasatwa BasuThis book provides a comprehensive overview of recent novel coronavirus (SARS-CoV-2) infection and discusses developments in the field of nanoparticle/inorganic/organic materials development for antiviral application, therapeutic applications, PPE kit formulations and inclusion of simulated data. The contents focus on measures to keep the infections in check, materials aspects for detection and monitoring, AI modeling for prediction of spread of the virus, among others. This book will be a useful reference for researchers, scientists and policy makers alike.
COVID-19 Pandemic, Geospatial Information, and Community Resilience: Global Applications and Lessons
by Abbas RajabifardGeospatial information plays an important role in managing location dependent pandemic situations across different communities and domains. Geospatial information and technologies are particularly critical to strengthening urban and rural resilience, where economic, agricultural, and various social sectors all intersect. Examining the United Nations' SDGs from a geospatial lens will ensure that the challenges are addressed for all populations in different locations. This book, with worldwide contributions focused on COVID-19 pandemic, provides interdisciplinary analysis and multi-sectoral expertise on the use of geospatial information and location intelligence to support community resilience and authorities to manage pandemics.
COVID-19 Pandemic Trajectory in the Developing World: Exploring the Changing Environmental and Economic Milieus in India (Advances in Geographical and Environmental Sciences)
by Mukunda Mishra R. B. SinghWe are witnessing an unprecedented global outbreak of COVID-19, which has been devastating in its consequences. Beyond the acute health hazard, the pandemic has carried with it other threats for mankind associated with the human economy, society, culture, psychology and politics. Amidst these multifarious dimensions of the pandemic, it is high time for global solidarity to save humankind.Human society, its ambient environment, the process of socio-economic development, and politics and power – all are drivers to establish the world order. All these parameters are intimately and integrally related. The interconnections of these three driving forces have a significant bearing on life, space and time. In parallel, the interrelationship between all these drivers is dynamic, and they are changed drastically with time and space. The statistics serve to align the thought, based on which social scientists need to understand the prevailing equation to project the unforeseen future. The trajectory of the future world helps in planning and policymaking with a scientific direction.The practitioners of all academic disciplines under the umbrella of the social sciences need a common platform to exchange ideas that may be effective in the sustainable management of the crisis and the way forward after it is mitigated. This book provides multidisciplinary contributions for expressing the solidarity of academic knowledge to fight against this global challenge. It is crucial that there should be an on-going discussion and exchange of ideas, not only from the perspective of the current times but keeping in view the preparedness for unforeseen post-COVID crises as well.
COVID-19: Paving the Way for a More Sustainable World (World Sustainability Series)
by Walter Leal FilhoThis book gathers and disseminates opinions, viewpoints, studies, forecasts, and practical projects which illustrate the various pathways sustainability research and practice may follow in the future, as the world recovers from the COVID-19 pandemic and prepares itself to the possibilities of having to cope with similar crisis, a product of the Inter-University Sustainable Development Research Programme (IUSDRP) https://www.haw-hamburg.de/en/ftz-nk/programmes/iusdrp.html and the European School of Sustainability Science and Research (ESSSR) https://esssr.eu/. The COVID-19 pandemic has led to severe human suffering, and to substantial damages to economies around the globe, affecting both rich countries and developing ones. The aftermath of the epidemic is also expected to be felt for sometime. This will also include a wide range of impacts in the ways sustainable development is perceived, and how the principles of sustainability are practised.There is now a pressing need to generate new literature on the connections between COVID-19 and sustainability. This is so for two main reasons. Firstly, the world crisis triggered by COVID-19 has severely damaged the world economy, worsening poverty, causing hardships, and endangering livelihoods. Together, these impacts may negatively influence the implementation of sustainable development as a whole, and of the UN Sustainable Development Goals in particular. These potential and expected impacts need to be better understood and quantified, hence providing a support basis for future recovery efforts. Secondly, the shutdown caused by COVID-19 has also been having a severe impact on teaching and research, especially –but not only – on matters related to sustainability. This may also open new opportunities (e.g. less travel, more Internet-based learning), which should be explored further, especially in the case of future pandemics, a scenario which cannot be excluded.The book meets these perceived needs.
COVID-19: Search for a vaccine (essentials)
by Patric U. VogelThis book presents the principle, strengths and weaknesses, and progress of various vaccine technologies against COVID-19. Additionally, important terms such as clinical phases, efficacy and sterilizing immunity are explained. In this second edition, the already approved vaccines are also presented and the importance of viral variants is explained
COVID-19: Suche nach einem Impfstoff (essentials)
by Patric U. VogelIn diesem Buch werden das Prinzip, die Stärken und Schwächen sowie der Fortschritt verschiedener Impfstofftechnologien gegen COVID-19 dargestellt. Es werden zusätzlich wichtige Begriffe wie klinische Phasen, Wirksamkeit und sterilisierende Immunität erklärt. In dieser zweiten Auflage werden auch die bereits zugelassenen Impfstoffe vorgestellt sowie die Bedeutung von Virusvarianten erklärt.
COVID-19, Supply Chain, Climate Change, and Sustainable Development in Africa: Current Business Issues in African Countries (CBIAC) Conference, Staten Island, NY, USA, April 7-8, 2022 (Springer Proceedings in Business and Economics)
by Shani D. CarterAll global countries are interdependent and all aspects of the global economy operate synergistically. The COVID-19 pandemic gave a renewed sense of urgency to focus on the synergies between supply chain, climate change, COVID-19, and sustainable development as they affect business in Africa and how what occurs in one part of the world affects the whole world. This book examines this synergy and the reciprocal impact of businesses, government, and society. Featuring contributions presented at the 2022 Current Business Issues in African Countries (CBIAC) Conference held at Wagner College in Staten Island, NY, USA, this book explores topics such as agriculture, entrepreneurship, education, gender, and capital flows in Africa demonstrating the wealth of business opportunities across the continent.
COVID-19: Systemic Risk and Resilience (Risk, Systems and Decisions)
by Igor Linkov Jesse M. Keenan Benjamin D. TrumpThis book aims to provide a collection of early ideas regarding the results of applying risk and resilience tools and strategies to COVID-19. Each chapter provides a distinct contribution to the new and rapidly growing literature on the developing COVID-19 pandemic from the vantage points of fields ranging from civil and environmental engineering to public policy, from urban planning to economics, and from public health to systems theory. Contributing chapters to the book are both scholars and active practitioners, who are bridging their applied work with critical scholarly interpretation and reflection. The book's primary purpose is to empower stakeholders and decision-makers with the most recent research in order that they can better understand the systemic and sweeping nature of the COVID-19 pandemic, as well as which strategies could be implemented to maximize socioeconomic and public health recovery and adaptation over the long-term.
COVID-ology: A Field Guide
by Michael T. Myers, Jr.The COVID-19 outbreak and response has been characterized by institutional missteps, media misinformation, and economic and social upheavals. This book is intended to de-mystify and inform in a succinct and straightforward text. The lessons shared are applicable to other infectious diseases and future inevitable pandemics. Readers will learn about the origins of COVID-19, the disease it causes, tests and how they work, therapeutics and prophylactic measures such as vaccines. This text prepares readers to be better able to respond to future emerging infectious diseases and pandemics. Key Features Positively influences career choices within public health Applies basic science to problems raised by the COVID-19 pandemic such as vaccine development and herd immunity Prepares readers with context and tactics for understanding future infectious disease outbreaks Successfully used in college senior health sciences seminars Engaging and balanced treatment of the politicization of public health issues, especially COVID-19 Related Titles Goswami, S. & C. Day, eds. COVID-19 and SARS-CoV-2: The Science and Clinical Application of Conventional and Complimentary Treatments (ISBN 9781032011950). Koley, T. K. & M. Dhole. The COVID-19 Pandemic: The Deadly Coronavirus Outbreak (ISBN 9780367558895). Ryan, J. M., ed. COVID-19 – Two volume set (ISBN 9780367740610).
The Cow: A Natural and Cultural History
by Professor Catrin RutlandA richly illustrated introduction to the science and history of the cowWe populate the countryside with cows the world over, and their familiar presence ensures that global demands for milk and beef are met. But with more than a billion cattle on the planet, the importance of cows extends well beyond food production. Cows are venerated by some religions and shunned by others; they provide leather for shoes, clothing, and other uses; and they have long been central to the agricultural way of life, working the fields, pulling carts, and providing fertilizer. The Cow is a comprehensive guide to help us understand these important animals, offering a wealth of information about their anatomy and behaviors, breed varieties, and place in human culture past and present. Exploring the cow’s livestock credentials and beyond, this book combines engaging and informative text, beautiful photographs, and explanatory diagrams to examine the cow's fascinating biology, its hard-wired behaviors, and its relationship with humankind.Provides an in-depth look at the evolution of the cow, its role in agriculture, and the development of breedsIncludes chapters on Anatomy & Biology, Society & Behavior, and Cattle & PeopleFeatures a photographic directory of forty global cattle breeds
The Cow with Ear Tag #1389
by Kathryn GillespieTo translate the journey from a living cow to a glass of milk into tangible terms, Kathryn Gillespie set out to follow the moments in the life cycles of individual animals—animals like the cow with ear tag #1389. She explores how the seemingly benign practice of raising animals for milk is just one link in a chain that affects livestock across the agricultural spectrum. Gillespie takes readers to farms, auction yards, slaughterhouses, and even rendering plants to show how living cows become food. The result is an empathetic look at cows and our relationship with them, one that makes both their lives and their suffering real.
Cowed: The Hidden Impact of 93 Million Cows on America’s Health, Economy, Politics, Culture, and Environment
by Denis Hayes Gail Boyer HayesFrom leading ecology advocates, a revealing look at our dependence on cows and a passionate appeal for sustainable living. In Cowed, globally recognized environmentalists Denis and Gail Boyer Hayes offer a revealing analysis of how our beneficial, centuries-old relationship with bovines has evolved into one that now endangers us. Long ago, cows provided food and labor to settlers taming the wild frontier and helped the loggers, ranchers, and farmers who shaped the country's landscape. Our society is built on the backs of bovines who indelibly stamped our culture, politics, and economics. But our national herd has doubled in size over the past hundred years to 93 million, with devastating consequences for the country's soil and water. Our love affair with dairy and hamburgers doesn't help either: eating one pound of beef produces a greater carbon footprint than burning a gallon of gasoline. Denis and Gail Hayes begin their story by tracing the co-evolution of cows and humans, starting with majestic horned aurochs, before taking us through the birth of today's feedlot farms and the threat of mad cow disease. The authors show how cattle farming today has depleted America's largest aquifer, created festering lagoons of animal waste, and drastically increased methane production. In their quest to find fresh solutions to our bovine problem, the authors take us to farms across the country from Vermont to Washington. They visit worm ranchers who compost cow waste, learn that feeding cows oregano yields surprising benefits, talk to sustainable farmers who care for their cows while contributing to their communities, and point toward a future in which we eat less, but better, beef. In a deeply researched, engagingly personal narrative, Denis and Gail Hayes provide a glimpse into what we can do now to provide a better future for cows, humans, and the world we inhabit. They show how our relationship with cows is part of the story of America itself.
Cowen's History of Life
by Michael J. BentonA newly revised and fully updated edition of the market-leading introduction to paleontology Designed for students and anyone else with an interest in the history of life on our planet, the new edition of this classic text describes the biological evolution of Earth’s organisms, and reconstructs their adaptations and the ecology and environments in which they functioned. Cowen's History of Life, 6th Edition includes major updates, including substantial rewrites to chapters on the origins of eukaryotes, the Cambrian explosion, the terrestrialization of plants and animals, the Triassic recovery of life, the origin of birds, the end-Cretaceous mass extinction, and human evolution. It also features new chapters on plants, soils and transformation of the land; the Mesozoic marine revolution; and the evolution of oceans and climates. Beginning with the origin of the Earth and the earliest life on earth, the book goes on to offer insightful contributions covering: the evolution of Metazoans; the early vertebrates; life of vertebrates on land; and early amniotes and thermoregulation. The book also looks at: dinosaur diversity, as well as their demise; early mammals; the rise of modern mammals; the Neogene Savannas; primates; life in the ice ages; and more. Covers the breadth of the subject in a concise yet specific way for undergrads with no academic background in the topic Reorganizes all chapters to reflect the geological series of events, enabling a new focus on big events Updated with three brand new chapters and numerous revised ones Put together by a new editorial team internationally recognized as the global leaders in paleontology Filled with illustrations and photographs throughout Includes diagrams to show internal structures of organisms, cladograms, time scales and events, and paleogeographic maps Supplemented with a dedicated website that explores additional enriching information and discussion, and which features images for use in visual presentations Cowen's History of Life, 6th Edition is an ideal book for undergraduate students taking courses in introductory paleontology, as well those on global change and earth systems.
Coxiella burnetii: Recent Advances And New Perspectives In Research Of The Q Fever Bacterium (Advances in Experimental Medicine and Biology #984)
by Rudolf Toman James E. Samuel Jean-Louis Mege Robert A. HeinzenCoxiella burnetii is the etiological agent of Q fever, a zoonotic disease found worldwide. The bacterium is a fascinating example of intracellular parasitism that has uniquely evolved to thrive in the most inhospitable of cellular compartments-the phagolysosome. Understanding how C. burnetii resists the degradative functions of this vacuole, and the host cell functions coopted for successful parasitism, are central to understanding Q fever pathogenesis. Recent achievements in glycomics and proteomics are guiding development of enhanced detection schemes for the bacterium in addition to shedding light on the host immune response to the pathogen. Several chapters survey immune functions that control or potentially exacerbate Coxiella infection and delve into correlates of protective immunity elicited by vaccination. Comparative genomics is also the foundation of chapters discussing diagnostic antigen discovery and molecular typing of the bacterium, with significance for development of new clinical, epidemiologic, and forensic tools.