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The Crisis of Progress: Science, Society, and Values
by John C. CaiazzaThis book is about the concept of progress, its separate varieties, its current rejection, and how it may be reconsidered from a philosophical and scientific basis. John C. Caiazza's main emphasis is on how science is understood as it has a direct impact on social values as expressed by prominent philosophers. He argues that progress is at a standstill, which presents a crisis for Western civilization.Caiazza presents historical examples, both of scientific inquiry and social and cultural themes, to examine the subject of progress. Beginning with the Whig model and progressive political values exemplified by Bacon and Dewey, he also examines other variations, the Enlightenment, cosmopolitanism, and totalitarianism. Technology, argues Caiazza, also has a stultifying effect on Western culture and to understand the idea of progress, we must take a philosophic rather than a scientific point of view. Modern cosmology has inevitable humanistic and theological implications, and major contemporary philosophers reject social science in favour of ancient concepts of virtue and ethics.In the end, Caiazza writes that time is an agent, not a neutral plain on which scientific and historical events occur. We can expect technology to keep us in stasis or become aware of the possibility of transcendence. This book will be of interest for students of scientific history and philosophy.
Crisis of the Wasteful Nation
by Ian TyrrellLong before people were "going green" and toting reusable bags, the Progressive generation of the early 1900s was calling for the conservation of resources, sustainable foresting practices, and restrictions on hunting. Industrial commodities such as wood, water, soil, coal, and oil, as well as improvements in human health and the protection of "nature" in an aesthetic sense, were collectively seen for the first time as central to the country's economic well-being, moral integrity, and international power. One of the key drivers in the rise of the conservation movement was Theodore Roosevelt, who, even as he slaughtered animals as a hunter, fought to protect the country's natural resources. In Crisis of the Wasteful Nation, Ian Tyrrell gives us a cohesive picture of Roosevelt's engagement with the natural world along with a compelling portrait of how Americans used, wasted, and worried about natural resources in a time of burgeoning empire. Countering traditional narratives that cast conservation as a purely domestic issue, Tyrrell shows that the movement had global significance, playing a key role in domestic security and in defining American interests around the world. Tyrrell goes beyond Roosevelt to encompass other conservation advocates and policy makers, particularly those engaged with shaping the nation's economic and social policies--policies built on an understanding of the importance of crucial natural resources. Crisis of the Wasteful Nation is a sweeping transnational work that blends environmental, economic, and imperial history into a cohesive tale of America's fraught relationships with raw materials, other countries, and the animal kingdom.
Crisis on the Coast and Hinterland: Assessing India’s East Coast with Geomorphological, Environmental and Remote Sensing and GIS Approaches
by Ashis Kumar Paul Anurupa PaulThis contributed volume assesses the state and future of India’s East Coast through a wide variety of chapters grouped by methodology and approach. Part I: Assessment through Geomorphological Approaches describes geomorphological diversities of the eastern shorelines of India, Coastal Modelling System- SMC and morphodynamics of Odisha coast, Paleo shorelines and beach ridge chenier formations of Subarnarekha delta, seasonal sediment budget of Chandrabhaga beachdune system, Beach stage and dune stage modelling Mandarmoni coast, drainage characters of South Andaman Islands, coastal foredune morphology and sediment of Odisha and West Bengal, Geo-archaeological pieces of evidence of ancient coastal environment, coastal sediment characters, beach ridge formation in the chenier coast, and geomorphological changes of ancient ports and harbours in the shoreline of West Bengal. Part II: Assessment through Environmental Approaches addresses various environmental assessment techniques of mangrove sensitivity to the sea level rise process in the Sundarban, land degradation of the hinterland drainage basins, the riparian environment of the coastal drainage basins, agricultural adaptability in response to climate variability in the coastal areas of West Bengal, forest degradations of the lateritic upland tracts, coastal tourism potentialities in Odisha and West Bengal, Climate variabilities and agricultural modifications in the hinterland areas of West Bengal districts, the tidal flat environment of Sagar Island, landforms and Geomorphosites for the promotion of Geotourism in South Andaman Perils of Premature Reclamation of Sundarban, marine litter in the coastal regions of West Bengal and Odisha on flora, fauna and humans, Ground water contamination due to saline water encroachment in coastal Andhra Pradesh and Spatio-temporal changes in the Hugli estuarine environment and coastal hazards and flood risk of southwestern Sundarban. Part III: Assessment through Remote Sensing & GIS Approaches uses the aforementioned techniques in service of exploration of monitoring health of Mangrove forest, Geomorphological analysis of the coral fringed coasts of Andaman, hydrological and morphological variations of Ichhamati Tidal estuary, multivariate analysis of coastal vulnerabilities, geography of tourism resources in Andaman group of islands, tourism climate index with application geospatial techniques, diversity of landscape ecology in the coastal blocks of Purba Medinipur, overwash vulnerability in Odisha coast, livelihood security index of the coastal communities, managing coastal squeeze response and wetland loss in the estuarine coastal tract of West Bengal, environmental effects of historical land reclamation process in the Sundarban, and emerging environmental problems of coastal urbanization in Digha, Kanthi, and Haldia.
Crisis Stability and Long-Range Strike: A Comparative Analysis of Fighters, Bombers, and Missiles
by Forrest E. MorganTo effectively manage an international crisis, the United States must balance its threats with restraint. It must posture forces in ways that deter aggression without implying that an attack is imminent, while limiting its own vulnerability to surprise attack. A RAND study sought to identify which long-range strike assetsâ#128;#148;strike fighters, bombers, ballistic missiles, cruise missilesâ#128;#148;offer capabilities most conducive to stabilizing such crises.
CRISPR: Biology and Applications (ASM Books #Volume 546)
by Rodolphe Barrangou Erik J. Sontheimer Luciano A. MarraffiniCRISPR CRISPR: BIOLOGY AND APPLICATIONS “An excellent compendium of all things CRISPR from some of the leading minds in the field. With thorough coverage from every angle and beautifully detailed illustrations, this book is not to be missed!” Jennifer A. Doudna, Professor of Chemistry, Biochemistry & Molecular Biology, UC Berkeley; Founder, Innovative Genomics Institute; Nobel Laureate and coinventor of CRISPR technology “This journey through CRISPR biology and several of its breakthrough applications offers an exciting glimpse into one of the most beautiful and compelling fields in the life sciences.” David R. Liu,Director of the Merkin Institute at the Broad Institute of MIT and Harvard; Professor of Chemistry and Chemical Biology at Harvard University; coinventor of base editing and prime editing “A must read! The CRISPR topics, written by world-leading experts, span from the fascinating mechanistic underpinnings to the ingenious applications. One can read from start to finish or pick and choose themes. Either way, the book delivers utterly enjoyable learning!” Bonnie Bassler, Squibb Professor and Chair, Princeton University Department of Molecular Biology; Howard Hughes Medical Institute Investigator CRISPR-Cas systems have revolutionized the science of gene editing and their possible applications continue to expand, from basic research to potentially groundbreaking medical and commercial uses. Led by a distinguished team of editors, CRISPR: Biology and Applications explores the subject matter needed to delve into this fascinating area. Topics covered include: Classification and molecular mechanisms of CRISPR-Cas systems CRISPR-Cas evolution, regulation, expression, and function Uses for gene editing and modulation of gene expression CRISPR-based antimicrobials and phage resistance for medical and industrial purposes Written by internationally renowned authors, CRISPR: Biology and Applications serves as both an introductory guide for those new to the field and an authoritative reference for seasoned researchers whose work touches this evolving and headline- making science.
Crispr: Methods and Protocols (Methods in Molecular Biology #1311)
by Magnus Lundgren Emmanuelle Charpentier Peter C. FineranThis volume presents a list of cutting-edge protocols for the study of CRISPR-Cas defense systems and their applications at the genomic, genetic, biochemical and structural levels. CRISPR: Methods and Protocols guides readers through techniques that have been developed specifically for the analysis of CRISPR-Cas and techniques adapted from standard protocols of DNA, RNA and protein biology. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, CRISPR: Methods and Protocols provides a broad list of tools and techniques to study the interdisciplinary aspects of the prokaryotic CRISPR-Cas defense systems.
CRISPR: A Machine-Generated Literature Overview
by Ping Wang Ziheng Zhang Ji-Long LiuThe book presents a machine-generated literature review on CRISPR (clustered regularly interspaced short palindromic repeats) from 114 selected papers published by Springer Nature in the last few years, which are then organized by the book editors with a human-written introduction to each chapter. Each chapter presents summaries of predefined themes and provides the reader with a basis for further exploration of the topic. As one of the experimental projects initiated by Springer Nature for AI book content generation, this book shows the latest developments in the CRISPR field. It will be a useful reference for graduate students who are interested in CRISPR-related research and early-career researchers who need an overview of the current development of the field.
CRISPR and Plant Functional Genomics
by Jen-Tsung ChenCRISPR is a crucial technology in plant physiology and molecular biology resulting in more sustainable agricultural practices, including outcomes of better plant stress tolerance and crop improvement. CRISPR and Plant Functional Genomics explores ways to release the potential of plant functional genomics, one of the prevailing topics in plant biology and a critical technology for speed and precision crop breeding. This book presents achievements in plant functional genomics and features information on diverse applications using the emerging CRISPR-based genome editing technologies producing high-yield, disease-resistant, and climate-smart crops. It also includes theories on organizing strategies for upgrading the CRISPR system to increase efficiency, avoid off-target effects, and produce transgene-free edited crops.Features: Presents CRISPR-based technologies, releasing the potential of plant functional genomics Provides methods and applications of CRISPR/Cas-based plant genome editing technologies Summarizes achievements of speed and precision crop breeding using CRISPR-based technologies Illustrates strategies to upgrade the CRISPR system Supports the UN’s sustainable development goals to develop future climate-resilient crops CRISPR and Plant Functional Genomics provides extensive knowledge of CRISPR-based technologies and plant functional genomics, and is an ideal reference for researchers, graduate students, and practitioners in the field of plant sciences as well as agronomy and agriculture.
CRISPR/Cas Genome Editing: Strategies And Potential For Crop Improvement (Concepts and Strategies in Plant Sciences)
by Anjanabha Bhattacharya Vilas Parkhi Bharat CharThis book offers a comprehensive collection of papers on CRISPR/Cas genome editing in connection with agriculture, climate-smart crops, food security, translational research applications, bioinformatics analysis, practical applications in cereals, floriculture crops, engineering plants for abiotic stress resistance, the intellectual landscape, regulatory framework, and policy decisions. Gathering contributions by internationally respected experts in the field of CRISPR/Cas genome editing, the book offers an essential guide for researchers, students, teachers and scientists in academia; policymakers; and public companies, private companies and cooperatives interested in understanding and/or applying CRISPR/Cas genome editing to develop new agricultural products.
CRISPR-Cas Methods (Springer Protocols Handbooks)
by M. Tofazzal Islam Pankaj K. Bhowmik Kutubuddin A. MollaThis volume details the fundamentals of the CRISPR-Cas system, and its protocols illustrate advances in CRISPR-Cas techniques for efficient genome editing. Introductory chapters provide a wide horizon of CRISPR/Cas-based methods and applications. Additional chapters guide readers through HDR-mediated editing, sgRNA design, the step-by-step procedure of multiplex adenine base editing experiments in rice, generating mutants for rice, wheat, Brachypodium, Barley, Flax, and Phytophthora, visual screening of mutants, gene deletion (knock-out), tagging (knock-in) in mammalian cells, the cloning-free (DNA-free) technique, cell-penetrating peptides, generating a genome-edited banana, and nuclear genome editing of Chlamydomonas employing CRISPR-Cpf1 combined with a single-stranded DNA (ssODN) repair template. Authoritative and cutting-edge, CRISPR-Cas Methods aims to assist researchers who are new to the field and are aiming to learn how best to adopt this technology for a particular organism.
CRISPR-Cas Methods: Volume 2 (Springer Protocols Handbooks)
by M. Tofazzal Islam Kutubuddin Ali MollaThis second volume provides new and updated methods detailing advancements in CRISPR-Cas technical protocols. Chapters guide readers through protocols on prime editing, base editing, multiplex editing, editing in cell-free extract, in silico analysis of gRNA secondary structure and CRISPR-diagnosis. Authoritative and cutting-edge, CRISPR-Cas Methods, Volume 2 aims to serves as a laboratory manual providing scientists with a holistic view of CRISPR-Cas methodologies and its practical application for the editing of crop plants, cell lines, nematode and microorganism.
CRISPR-Cas Methods: Volume 3 (Springer Protocols Handbooks)
by M. Tofazzal Islam Kutubuddin Molla Pankaj Bhowmik Kabin XieThis third edition expands upon the previous two editions with new and updated methods presenting comprehensive, step-by-step protocols for recently developed techniques that were not included in the earlier volumes. Chapters feature contributions from the globally leading experts in the field, aiming to equip researchers with the practical tools necessary for successful CRISPR experimentation. Authoritative and cutting-edge, CRISPR-Cas Methods, Volume 3 aims to be a useful and practical guide for researches to help further their study in this field.
CRISPR-Cas Systems: RNA-mediated Adaptive Immunity in Bacteria and Archaea
by Rodolphe Barrangou and John van der OostCRISPR/Cas is a recently described defense system that protects bacteria and archaea against invasion by mobile genetic elements such as viruses and plasmids. A wide spectrum of distinct CRISPR/Cas systems has been identified in at least half of the available prokaryotic genomes. On-going structural and functional analyses have resulted in a far greater insight into the functions and possible applications of these systems, although many secrets remain to be discovered. In this book, experts summarize the state of the art in this exciting field.
The CRISPR/Cas Tool Kit for Genome Editing
by Aftab Ahmad Sultan Habibullah Khan Zulqurnain KhanThis book discusses CRISPR/Cas- one of the most powerful tools available to scientists for genome editing. CRISPR/Cas is not only a genome editing tool, but researchers have also engineered it for gene regulation, genome imaging, base editing and epigenome regulations. This book describes the entire toolkit for CRISPR/Cas. The opening section gives an introduction to the technique and compares it with other genome editing tools. Further section gives a historical perspective of the tool, along with its detailed classification. The next chapters describe bioinformatic tools in CRISPR/Cas, and delivery methods for CRISPR/Cas. The book also discusses about the applications of CRISPR/Cas beyond genome editing and use of CRISPR for rewriting genetic codes. The book dedicates a section to the use of CRISPR in plants. The book culminates with a chapter on the current status, challenges and shortcomings of the CRISPR/Cas genome editing tool. The book would be highly interesting to students and researchers in molecular biology, biochemistry, biotechnology, food science, agriculture and plant sciences.
CRISPR/Cas9 – Einschneidende Revolution in der Gentechnik
by Toni Cathomen Holger PuchtaDie Biologie erlebt zurzeit die größte Revolution seit 30 Jahren. Der Auslöser: die molekulare Schere CRIPSR/Cas. Mit ihr ist es möglich, einfach und effizient die genetische Information eines Organismus zu verändern. Das hat weitreichende Konsequenzen für unser aller Leben. In der Landwirtschaft wie in der Medizin werden Dinge machbar, die vor wenigen Jahren noch für unmöglich erachtet wurden: Weizen und Tomaten, die resistent gegen Mehltaubefall sind, und Patienten, die nun die Aussicht haben, ihre tödliche Krankheit zu überleben.In diesem Buch haben wir eine Reihe von allgemeinverständlichen Artikeln zusammengestellt, die in den letzten Jahren in Nature, Spektrum der Wissenschaft, ZEIT und FAZ zu diesem Thema veröffentlicht wurden und die folgenden Fragen beantworten:· Woher kommt CRISPR/Cas und wie funktioniert es?· Wie können wir damit bessere Kulturpflanzen züchten?· Welche Krankheiten können wir damit heilen?· Was sind die Hoffnungen? Was sind die Risiken? · Was ist ethisch vertretbar und wo setzen wir die Grenzen? Sind wir auf dem Weg zum künstlichen Menschen?
CRISPR-/Cas9 Based Genome Editing for Treating Genetic Disorders and Diseases
by Luis María VaschettoThe CRISPR-Cas9 genome-editing system is creating a revolution in the science world. In the laboratory, CRISPR-Cas9 can efficiently be used to target specific genes, correct mutations and regulate gene expression of a wide array of cells and organisms, including human cells. CRISPR-/Cas9 Based Genome Editing for Treating Genetic Disorders and Diseases is a unique reading material for college students, academicians, and other health professionals interested in learning about the broad range of applications of CRISPR/Cas9 genetic scissors. Some topics included in this book are: the role of the CRISPR/Cas9 system in neuroscience, gene therapy, epigenome editing, genome mapping, cancer, virus infection control strategies, regulatory challenges and bioethical considerations.
CRISPR Crops: The Future of Food Security
by Aftab Ahmad Sultan Habibullah Khan Zulqurnain KhanThis book compiles the latest applications of the cutting-edge gene editing tool CRISPR/Cas in the area of crop improvement. It begins with an introduction to the technique and its application in crop plants. Next, it gives an updated overview of available delivery methods, design tools and resources in CRISPR/Cas. The book subsequently reviews the applications of CRISPR/Cas in connection with e.g. insect stress, disease stress, abiotic stress, nutritional and yield improvement in crop plants, etc. It also discusses the various regulatory, ethical and social aspects of the technique that must be kept in mind when designing experiments. In closing, the book summarizes the status quo and outlines future prospects for the tool in crop improvement and food security.Given its scope, the book will especially benefit students and researchers in food science, biotechnology, agriculture and the plant sciences.
CRISPR Guide RNA Design: Methods and Protocols (Methods in Molecular Biology #2162)
by Tudor A. Fulga David J. H. F. Knapp Quentin R. V. FerryThis detailed volume focuses on the CRISPR-associated guide RNA and how it can be designed, modified, and validated for a broad repertoire of purposes. Beginning with a section on computational design of target-specific guide RNAs, the book continues by covering chemical modifications to alter guide RNA stability, specificity, and efficiency, as well as to create inducible guide RNAs, append additional functional domains, and express guide RNAs in a conditional manner. It concludes with methods for measuring off-target guide RNA activity. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and essential, CRISPR Guide RNA Design: Methods and Protocols provides a comprehensive pipeline for guide RNA design and aims to be an invaluable resource in applying this powerful technology to basic research and therapeutic applications.
CRISPR People: The Science and Ethics of Editing Humans
by Henry T. GreelyWhat does the birth of babies whose embryos had gone through genome editing mean--for science and for all of us?In November 2018, the world was shocked to learn that two babies had been born in China with DNA edited while they were embryos--as dramatic a development in genetics as the cloning of Dolly the sheep was in 1996. In this book, Hank Greely, a leading authority on law and genetics, tells the fascinating story of this human experiment and its consequences. Greely explains what Chinese scientist He Jiankui did, how he did it, and how the public and other scientists learned about and reacted to this unprecedented genetic intervention.
Criteria Air Pollutants and their Impact on Environmental Health
by Pallavi Saxena Saurabh SonwaniAir pollution is a global hazard. Majority of the world’s population is affected by air pollution. Contamination of air is no more an only an atmospheric problem but now has become a health concern too. Under the Clean Air Act of 1971, a set of air pollutants are designated as criteria pollutants. These are suspected to be strongly harming the public health and the environment as compared to other primary and secondary pollutants. Globally, this category of air pollutants has been given less attention, only few studies have been reported in this area. This book begins with a short background on criteria air pollutants and their sources, sinks and chemistry. The chapters explore the detailed nature of primary pollutants criteria pollutants such as nitrogen dioxide, sulphur dioxide, carbon monoxide, particulate matter and lead. Their reaction mechanisms, climate change potency, environmental health effects on plants and human life are discussed. The book also covers secondary pollutants such as ozone. The book discusses ozone chemistry and its environmental health effects. This book act as a valuable tool for students in Environmental Science, Biological Science and Agriculture, as well as environmental consultants and professionals involved in air quality research and the application of air quality guidelines and advice.
Critical Analysis of Science Textbooks: Evaluating instructional effectiveness
by Myint Swe KhineThe critical analysis of science textbooks is vital in improving teaching and learning at all levels in the subject, and this volume sets out a range of academic perspectives on how that analysis should be done. Each chapter focuses on an aspect of science textbook appraisal, with coverage of everything from theoretical and philosophical underpinnings, methodological issues, and conceptual frameworks for critical analysis, to practical techniques for evaluation. Contributions from many of the most distinguished scholars in the field give this collection its sure-footed contemporary relevance, reflecting the international standards of UNESCO as well as leading research organizations such as the American Association for the Advancement of Science (whose Project 2061 is an influential waypoint in developing protocols for textbook analysis). Thus the book shows how to gauge aspects of textbooks such as their treatment of controversial issues, graphical depictions, scientific historiography, vocabulary usage, accuracy, and readability. The content also covers broader social themes such as the portrayal of women and minorities. "Despite newer, more active pedagogies, textbooks continue to have a strong presence in classrooms and to embody students' socio-historical inheritance in science. Despite their ubiquitous presence, they have received relatively little on-going empirical study. It is imperative that we understand how textbooks influence science learning. This book presents a welcome and much needed analysis." Tina A. Grotzer Harvard University, Cambridge, Massachusetts, USA The present book provides a much needed survey of the current state of research into science textbooks, and offers a wide range of perspectives to inform the 'science' of writing better science textbooks. Keith S Taber University of Cambridge, Cambridge, United Kingdom
Critical and Rare Earth Elements: Recovery from Secondary Resources
by Abhilash Pillai Ata AkcilThis book is aimed to compile the distribution of rare earth elements in various resources with their processing from secondary resources. It includes details of various processes developed for extraction of rare earth elements from varied raw materials ranging from e-wastes, tailings, process wastes and residues. It emphasizes importance of processing of the secondary resources to assist environmental remediation of such untreated wastes and get finished products. It covers all aspects of rare metals and rare earth metals in one volume covering extraction, separation and recycling of secondary resources for extraction of these metals along with relevant case studies.
A Critical Appraisal of Viral Taxonomy
by R. E. MatthewsThe overall aim of this volume is to review critically the current state of, and future prospects for developments in viral taxonomy.
A Critical Approach to International Water Management Trends
by Christian Bréthaut Rémi SchweizerThis edited volume provides a critical discussion of particular trends that are widely recognised to influence water management by comparing them with what is actually happening in the field. Among others, these trends include water security, adaptive or integrative management, and the water-energy-food nexus, which are often presented as essential means to reaching more sustainable and resilient water use. However, the extent to which these trends have managed to structure concrete practices in water management remains uncertain. Informed by empirically grounded research, each chapter of this work engages with a particular approach, concept or theory. Together, they provide a nuanced picture of trends in water management that require universal remedies and global norms.
Critical Approaches to Science and Religion
by Sheldon, Myrna Perez; Ragab, Ahmed; Keel, TerenceCritical Approaches to Science and Religion offers a new direction for scholarship on science and religion that examines social, political, and ecological concerns long part of the field but never properly centered. The works that make up this volume are not preoccupied with traditional philosophical or theological issues. Instead, the book draws on three vital schools of thought: critical race theory, feminist and queer theory, and postcolonial theory. Featuring a diverse array of contributors, it develops critical perspectives by examining how histories of empire, slavery, colonialism, and patriarchy have shaped the many relationships between science and religion in the modern era. In so doing, this book lays the groundwork for scholars interested in speaking directly to matters such as climate change, structural racism, immigration, health care, reproductive justice, and sexual identity.