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Development of New Radical Cascades and Multi-Component Reactions
by Marie-Helene LarraufieIn this dissertation, Marie-Hélène Larraufie develops original radical and pallado-catalyzed methodologies to enable the synthesis of several classes of bioactive nitrogen-containing heterocycles. New radical cascades employing the N-acylcyanamide moiety offer straightforward routes to quinazolinones and guanidines, as well as new insights into the mechanism of homolytic aromatic substitutions. In parallel, Larraufie expands the scope of visible light photoredox catalysis to the ring opening of epoxides and aziridines, thus providing new sustainable alternatives for the generation of radicals. Furthermore, in a collaborative effort with the Catellani group, the author investigates dual palladium/norbornene catalysis. First, she develops a C-amination coupling variant of the Catellani reaction with unprotected amines which provides an expeditious route to phenanthridines. Then, she examines the influence of the chelating effect on Pd(IV) intermediates reactivity with the help of experimental studies and DFT calculations. The work in this thesis has resulted in numerous publications in high impact journals. The clarity and depth of the experimental section will be useful for students and researchers working in this field.
Development of Novel Bioelectrochemical Membrane Separation Technologies for Wastewater Treatment and Resource Recovery (Springer Theses)
by Yunkun WangThe most commonly used biological wastewater treatment technologies still have serious technical-economical and sustainability-related limitations, due to their high energy requirements, poor effluent quality, and lack of energy and resource recovery processes. In this thesis, novel electrochemical membrane bioreactors (EMBRs), which take advantage of membrane separation and bioelectrochemical techniques, are developed for wastewater treatment and the simultaneous recovery of energy and resources. Above all, this innovative system holds great promise for the efficient wastewater treatment and energy recovery. It can potentially recover net energy from wastewater while at the same time harvesting high-quality effluent. The book also provides a proof-of-concept study showing that electrochemical control might offer a promising in-situ means of suppressing membrane fouling. Lastly, by integrating electrodialysis into EMBRs, phosphate separation and recovery are achieved. Hence, these new EMBR techniques provide viable alternatives for sustainable wastewater treatment and resource recovery.
Development of Novel Hydrogen-Bond Donor Catalysts
by Tsubasa InokumaThis work describes novel, effective hydrogen-bond (HB) donor catalysts based on a known bifunctional tertiary amine-thiourea, a privileged structure, which has been proven to be one of the most widely used organocatalysts. These HB donor catalysts derived from quinazoline and benzothiadiazine were initially synthesized as novel HB donors with their HB-donating abilities being measured by analytical methods. They were found to be effective for a variety of asymmetric transformations including Michael reactions of a, b-unsaturated imides and hydrazination reactions of 1,3-dicarbonyl compounds. Thiourea catalysts that have an additional functional group are also described. Specifically, thioureas that bear a hydroxyl group were synthesized and subsequently used as novel bifunctional organocatalysts for catalytic, asymmetric Petasis-type reactions involving organoboronic acids as nucleophiles. These addition reactions were difficult to achieve using existing organocatalysts. One of the developed catalytic methods can be applied to the synthesis of biologically interesting peptide-derived compounds possessing unnatural vinyl glycine moieties. These findings introduce new criteria required for the development of organocatalysts for asymmetric reactions, thus making a significant contribution to the field of organocatalysis.
Development of Novel Stability Indicating Methods Using Liquid Chromatography
by Mukesh Maithani Parveen BansalReversed-phase high-performance liquid chromatography (RP-HPLC) has become the most widely used method for pharmaceutical analysis, as it ensures accuracy, specificity and reproducibility for the quantification of drugs, while avoiding interference from any of the excipients that are normally present in pharmaceutical dosage forms. This book presents a simple methodology for developing stability-indicating methods and offers a ‘how-to guide’ to creating novel stability-indicating methods using liquid chromatography. It provides the detailed information needed to devise a stability-indicating method for drug substances and drug products that comply with international regulatory guidelines. As such, it is a must-read for anyone engaged in analytical and bioanalytical chemistry: professionals at reference, test, and control laboratories; students and academics at research laboratories, and scientists working for chemical, pharmaceutical, and biotechnology companies.
Development of Redox Mediators for High-Energy-Density and High-Efficiency Lithium-Oxygen Batteries (Springer Theses)
by Youngmin KoThis thesis addresses the introduction of redox mediator into lithium-oxygen batteries to improve their electrochemical performance especially in terms of practical energy density and round-trip efficiency. In chapter 1, basic electrochemistry regarding lithium-oxygen batteries and redox mediators are introduced. In chapter 2 to 4, comprehensive researches including the discovery of a new redox mediator inspired by biological system, the investigation on kinetic property of redox mediator, and the prevention of shuttle phenomenon are introduced, followed by chapter 5 summarizing the contents. This thesis is targeted to students and researchers interested in electrochemistry and energy storage systems.
Development of Science Teachers' TPACK
by Ying-Shao HsuScience is a subject matter that requires learners to explore the world and develop their own abilities on the basis of that exploration. As technology broadens and deepens, science teachers need to expand their Technological Pedagogical Content Knowledge (TPACK), which determines how well they use technology to help students learn science. The book details our efforts to prepare science teachers to teach with the help of technology, examining various aspects of teacher education, professional development and teaching material preparation. It consists of three parts, which focus on: how TPACK is conceptually constructed within the field of science education, how teacher evaluation and teaching materials are developed and utilized based on the transformative model and how science teachers are prepared and supported with electronic resources based on the integrative model. The book offers a valuable resource for all those working in science education, as well as those readers who are interested in teacher education. Science teachers will come to know how simulations and animations can pedagogically support student learning. Practices for teachers' TPACK development such as learning-by-design, evaluation and measurement and teacher communities are also addressed, applied and discussed in the case of science teachers. The individual chapters will provide teacher educators and researchers from all disciplines with new insights into preparing teachers for the Digital Era.
Development of Selective DNA-Interacting Ligands: Understanding the Function of Non-canonical DNA Structures (Springer Theses)
by Sefan AsamitsuThis book addresses the development of both DNA-sequence-selective and DNA-form-selective ligands, with the aim of creating potential molecular probes and therapeutic agents for non-canonical DNA structure-caused human diseases. Over the past two decades, the structural diversity of DNA forms has been proven to have profound implications in various biological, neurological, and pharmacological events. In response, researchers have since made tremendous efforts to obtain highly active drugs interacting with disease-related non-canonical DNA structures. These drugs, however, have not yet been approved for clinical use. One obstacle impeding their clinical application has to do with selectivity. This book focuses on secondary DNA structures formed by trinucleotide repeat sequences (“hairpin form”) or guanine-rich sequences (“G-quadruplex form”), both of which are pathological molecules for neurodegenerative diseases and/or cancer. Most importantly, it contends that a particular secondary structure of DNA in the context of the human genome can be targeted with a minimal affinity to other DNA structures by means ofcareful and rational ligand design. This approach opens an avenue to the development of highly selective drugs or diagnostic chemical tools for human diseases. Readers who want to know how synthetic ligands can be designed to selectively target a certain DNA molecule will find this book highly informative.
Development of Sensory and Neurosecretory Cell Types: Vertebrate Cranial Placodes, volume 1 (Evolutionary Cell Biology)
by Gerhard SchlosserMost of the cranial sense organs of vertebrates arise from embryonic structures known as cranial placodes. Such placodes also give rise to sensory neurons that transmit information to the brain as well as to many neurosecretory cells. This book focuses on the development of sensory and neurosecretory cell types from cranial placodes by introducing the vertebrate head with its sense organs and neurosecretory organs and providing an overview of the various cranial placodes and their derivatives, including evidence of common embryonic primordia. Schlosser discusses how these primordia are established in the early embryo and how individual placodes develop. The latter chapters explain how various placodally derived sensory and neurosecretory cell types differentiate into discrete structures.
Development of Smart Context-Aware Services for Cargo Transportation: An Operational Management Approach (International Series in Operations Research & Management Science #330)
by Dalė Dzemydienė Aurelija Burinskienė Kristina Čižiūnienė Arūnas MiliauskasWith a focus on cargo transportation, this book addresses the development of approaches intended to secure an infrastructure of smart services to support the adaptive implementation of online multi-modal freight transport management processes. It discusses the development of multi-criteria decision-making components and their integration into the multi-layered computer-based information management of intelligent systems. Through detailed descriptions of various components of intelligent transport management systems, the book demonstrates how to develop the services needed in the right place and at the right time, and how to properly adapt to user needs, making necessary interventions to ensure the safety of the transportation process. Further, it describes the main ways to increase the autonomy and efficiency of user-vehicle interaction and shows how Information and Communications Technology (ICT) structural support for current and past situations in AI-based systems can help to anticipate future developments in freight transportation.
Development of Solar Cells: Theory and Experiment (Challenges and Advances in Computational Chemistry and Physics #32)
by Jerzy Leszczynski Supratik Kar Juganta K. RoyThis book presents a comprehensive overview of the fundamental concept, design, working protocols, and diverse photo-chemicals aspects of different solar cell systems with promising prospects, using computational and experimental techniques. It presents and demonstrates the art of designing and developing various solar cell systems through practical examples. Compared to most existing books in the market, which usually analyze existing solar cell approaches this volume provides a more comprehensive view on the field. Thus, it offers an in-depth discussion of the basic concepts of solar cell design and their development, leading to higher power conversion efficiencies. The book will appeal to readers who are interested in both fundamental and application-oriented research while it will also be an excellent tool for graduates, researchers, and professionals working in the field of photovoltaics and solar cell systems.
Development of Sustainable Thermal Insulators from Waste Materials: A Circular Economy Approach (Materials Horizons: From Nature to Nanomaterials)
by Sarika Verma A. K. Srivastava Mohd. Akram KhanThis book focuses on the major global waste management issues and development of thermal insulating materials by utilizing these wastes. It helps address various global issues like sustainable environment, waste to wealth, waste to resource material, advanced multifunctional material, skill development and employment generation. The book highlights the potentiality and the applicability of various wastes, such as municipal solid waste, agricultural waste, industrial waste, construction waste, textile waste, waste polystyrene, geopolymer, leather rubber waste, other miscellaneous waste to be considered as a resource and its availability and conversion technologies from waste to wealth as thermal insulating materials. It also discusses recent trends, for processing the waste to wealth as a thermally insulating material. This book is a useful guide to researchers and professionals working in the areas of energy storage, sustainable civil engineering, material science and others allied fields.
Development of Synthetic Methods for Novel Photofunctional Multinuclear Complexes: Simple Synthetic Methods for Multinuclear Complexes Using Various C-C Coupling Reactions (Springer Theses)
by Yasuomi YamazakiThis book presents several helpful synthetic methods for diverse multinuclear complexes. The results described can be used to selectively connect mononuclear as well as multinuclear complexes with other metal complexes to construct valuable photofunctional compounds. Using the new synthetic methods, it was possible to selectively connect several types of metal complexes in a single step under relatively mild reaction conditions. This so-called building block approach utilizes various C–C coupling reactions between metal complexes with functional groups as active moieties. Owing to the large pi-conjugation systems, the multinuclear complexes synthesized using coupling reactions showed a strong absorption ability over a wide range of visible light and long emission lifetimes, which are ideal properties for photosensitizers and light absorbers. By combining these coupling methods with the newly developed hydrogenation reactions, the binding mode of the linkers in multinuclear complexes can be modified in order to tune the photophysical properties and photocatalytic ability. As such, the synthesized multinuclear complexes can be used for various purposes, e.g., as photocatalysts and photosensitizers, and in light-harvesting systems. The synthetic methods and strategies presented in this book diversify not only the structures but also functions of multinuclear complexes.
Development of The Ocular Lens
by Frank J. Lovicu Michael L. RobinsonThis book provides a comprehensive view of research in lens developmental biology, emphasising technical and molecular breakthroughs. Elucidation of the mechanisms that govern lens development has enabled us to understand how the normal lens forms and how developmental processes are involved in the maintenance of its normal structure, function and growth throughout life. This knowledge is fundamental to our understanding of many lens disorders. The ocular lens has also become a model for understanding the developmental biology of more complex organ systems. In this 2004 book, leading experts in lens cell biology and development discuss lens evolution, induction, morphology, the regulation of the lens cell cycle and fiber cell differentiation, as well as lens regeneration. This book is an authoritative treatment of the subject that will serve as a reference for graduate students and research scientists in developmental biology and in the visual sciences, as well as for ophthalmologists.
Development of a New Heterocycle-Forming Reaction and Kinetic Resolution with N-Heterocyclic Carbenes (Springer Theses)
by Yinli WangIn this book, the author focuses on exploring new organocatalytic transformations under operationally simple and environmentally friendly reaction conditions. Two new types of catalytic reactions promoted by N-heterocyclic carbenes (NHCs) are described. The oxa- and azacycle-forming reactions of sulfonylalkynols and sulfonylalkynamides are broadly considered to be a new type of activation mode in NHC chemistry, wherein the bond formation with internal O- and N-nucleophiles occurs at the γ-position of the propargyl sulfones with 1,2-sulfonyl migration. The resulting oxa- and azacycles are core structures in many biologically significant compounds and medicinally important agents. In addition, the book develops the chiral NHC-catalyzed kinetic resolution of α-hydroxy carboxylic acid derivatives based on chiral recognition of the substrate–cocatalyst complex. In this carboxylate cocatalyst-assisted chiral acylation, the reaction rate acceleration and selectivity enhancement are interpreted in terms of the reversible complexation of the substrate and carboxylate cocatalyst, which is verified by control experiments and measured using analytical methods. The findings described here reveal a promising new aspect of not only NHC catalysis but also identifying novel catalysis systems.
Development of a Numerical Simulation Method for Rocky Body Impacts and Theoretical Analysis of Asteroidal Shapes (Springer Theses)
by Keisuke SugiuraThis book describes numerical simulations of collisions between asteroids, based on a unique numerical code developed by the author. The code accurately solves the elastic dynamic equations and describes the effects of fracture and friction, which makes it possible to investigate the shapes of impact outcomes produced by asteroid collisions and subsequent gravitational accumulation of fragments.The author parallelizes the code with high parallelization efficiency; accordingly, it can be used to conduct high-resolution simulations with the aid of supercomputers and clarify the shapes of small remnants produced through the catastrophic destruction of asteroids. The author demonstrates that flat asteroids can only be produced by impacts involving objects with similar mass and low velocity, which suggests that the flat asteroids in our solar system were created in the planet formation era and have kept their shapes until today. The author also shows that asteroid collisions under certain conditions can produce the extremely elongated shape of an interstellar minor body, 1I/‘Oumuamua. In brief, the book offers a comprehensive investigation of asteroid impacts and shapes, making it a uniquely valuable resource.
Development of a Sub-glacial Radio Telescope for the Detection of GZK Neutrinos
by Thomas MeuresThe goal of the project presented in this book is to detect neutrinos created by resonant interactions of ultrahigh energy cosmic rays on the CMB photon field filling the Universe. In this pioneering first analysis, the author puts forward much of the analysis framework, including calibrations of the electronic hardware and antenna geometry, as well as the development of algorithms for event reconstruction and data reduction. While only two of the 37 stations planned for the Askaryan Radio Array were used in this assessment of 10 months of data, the analysis was able to exclude neutrino fluxes above 10 PeV with a limit not far from the best current limit set by the IceCube detector, a result which establishes the radio detection technique as the path forward to achieving the massive volumes needed to detect these ultrahigh energy neutrinos.
Development of an Efficient Modelling Approach to Support Economically and Socially Acceptable Flood Risk Reduction in Coastal Cities: Can Tho City, Mekong Delta, Vietnam (IHE Delft PhD Thesis Series)
by Hieu Quang NgoFlooding is one of the most frequently occurring and damaging natural disasters worldwide. Quantitative flood risk management (FRM) in the modern context demands statistically robust approaches (e.g. probabilistic) due to the need to deal with complex uncertainties. However, probabilistic estimates often involve ensemble 2D model runs resulting in large computational costs.Additionally, modern FRM necessitates the involvement of a broad range of stakeholders via co-design sessions. This makes it necessary for the flood models, at least at a simplified level, to be understood by and accessible to non-specialists. This study was undertaken to develop a flood modelling system that can provide rapid and sufficiently accurate estimates of flood risk within a methodology that is accessible to a wider range of stakeholders for a coastal city – Can Tho city, Mekong Delta, Vietnam. A web-based hydraulic tool, Inform, was developed based on a simplified 1D model for the entire Mekong Delta, flood hazard and damage maps, and estimated flood damages for the urban centre of Can Tho city (Ninh Kieu district), containing the must-have features of a co-design tool (e.g. inbuilt input library, flexible options, easy to use, quick results, user-friendly interface). Inform provides rapid flood risk assessments with quantitative information (e.g. flood levels, flood hazard and damage maps, estimated damages) required for co-designing efforts aimed at flood risk reduction for Ninh Kieu district in the future.
Development of an Ultrafast Low-Energy Electron Diffraction Setup
by Max GuldeThis book presents an Ultrafast Low-Energy Electron Diffraction (ULEED) system that reveals ultrafast structural changes on the atomic scale. The achievable temporal resolution in the low-energy regime is improved by several orders of magnitude and has enabled the melting of a highly-sensitive, molecularly thin layer of a polymer crystal to be resolved for the first time. This new experimental approach permits time-resolved structural investigations of systems that were previously partially or totally inaccessible, including surfaces, interfaces and atomically thin films. It will be of fundamental importance for understanding the properties of nanomaterials so as to tailor their properties.
Development of an Ultrasonic Sensing Technique to Measure Lubricant Viscosity in Engine Journal Bearing In-Situ
by Michele SchirruThis thesis presents a novel ultrasonic instrument for non-invasive and in-situ characterization of journal bearing lubricant viscosity. In particular, the application to journal bearings is described by non-invasively measuring the viscosity and localized power losses throughout operation. This ultrasonic viscometer is based on the reflection of polarized shear waves from a thin resonating coating layer to increase the measurement sensitivity, in comparison to conventional ultrasonic methods. This instrument allows for a full engine oil viscoelastic characterization in-situ. The book investigates the effects of temperature, pressure and shear rate, and describes in detail the ultrasonic setup and method. Further, it demonstrates that the same technique can be applied similarly to monitor the lubrication of other engine components. As such, it offers a unique instrument that can drive the research of oil formulations to improve engine performance and fulfill the requirements of international fuel economy regulations.
Development, Inclusion and Sustainability: Issues and Perspectives (Sustainable Development Goals Series)
by Amrita Datta Abhinav Alakshendra Bhim ReddyThis book addresses the overarching theme of promoting inclusive and sustainable development through twelve contributions that discuss perspectives from emerging economies and policies for a better world. The contributions are divided into four sections -- Employment and Livelihoods; Capabilities and Mobilities; Sustainable and Inclusive Urbanization; and Perspectives for Policies. The first section contains two chapters that deal with employment and labour markets. In the second section, there are four contributions that discuss capabilities (education and health) and their roles in intergenerational mobility, contributing to poverty reduction and inclusive development. The third section comprises of four chapters concerning various aspects of urbanisation in diverse empirical contexts. And the last section consists of two contributions providing policy perspectives. The volume is thus a diverse mix of empirical research and provides critical insights into the Global South’s development process. It is an important reference for all those concerned with sustainable and inclusive development.
Development, Regeneration and Plasticity of the Autonomic Nervous System
by I. A. Hendry C. E. HillEach volume in the Autonomic Nervous System series deals with a different area of autonomic control in health and disease. This, the second volume, provides an overview on the nature of the factors that exert constraints on the differentiation and maturation of the autonomic nervous system. Subjects covered include: development of autonomic neurones; molecules affecting nerve growth and survival; regeneration after injury; and the degree to which the wiring of the nervous system is rigid or fixed.
Development: Mechanisms of Change (Darwin College Lectures #29)
by Torsten Krude Sara T. BakerThis volume collects essays from prominent intellectuals and public figures based on talks given at the 2015 Darwin College Lectures on the theme of 'development'. The writers are world-renowned experts in such diverse fields as architecture, astronomy, biology, climate science, economy, psychology, sports and technology. Development includes contributions from developmental biologist and Nobel laureate John B. Gurdon, Olympic gold medallist Katherine Grainger, astronomer and cosmologist Richard Ellis, developmental psychologist Bruce Hood, former Met Office Chief Scientist Julia Slingo, architect Michael Pawlyn, development economist Ha-Joon Chang and serial entrepreneur Hermann Hauser. While their perspectives and interpretations of development vary widely, their essays are linked by a common desire to describe and understand how things change, usually in the direction of ever-increasing complexity. Written with the lay reader in mind, this interdisciplinary book is a must-read for anybody interested in the mechanisms underlying the changes we see in the world around us.
Developmental Approaches to Human Evolution
by Julie Boughner Campbell RolianDevelopmental Approaches to Human Evolution encapsulates the current state of evolutionary developmental anthropology. This emerging scientific field applies tools and approaches from modern developmental biology to understand the role of genetic and developmental processes in driving morphological and cognitive evolution in humans, non-human primates and in the laboratory organisms used to model these changes. Featuring contributions from well-established pioneers and emerging leaders, this volume is designed to build research momentum and catalyze future innovation in this burgeoning field. The book's broad research scope encompasses soft and hard tissues of the head and body, including the skeleton, special senses and the brain. Developmental Approaches to Human Evolution is an invaluable resource on the mechanisms of primate and vertebrate evolution for scholars across a wide array of intersecting disciplines, including primatology, paleoanthropology, vertebrate morphology, evolutionary developmental biology and health sciences.
Developmental Behavioral Neuroscience: The Minnesota Symposia on Child Psychology, Volume 24 (Minnesota Symposia on Child Psychology Series #Vol. 24)
by Megan R. Gunnar Charles A. NelsonThis volume provides an introduction to current research on the relation between brain development and the development of cognitive, linguistic, motor, and emotional behavior. At least two audiences will benefit from this book: psychologists interested in brain development, and neuroscientists interested in behavioral development. Although each chapter is content-oriented, the volume as a whole provides a well integrated summary of the latest findings from developmental behavioral neuroscience.
Developmental Biology
by Scott F. Gilbert Michael J. F. BarresiA classic gets a new coauthor and a new approach: Developmental Biology, Eleventh Edition, keeps the excellent writing, accuracy, and enthusiasm of the Gilbert Developmental Biology book, streamlines it, adds innovative electronic supplements, and creates a new textbook for those teaching Developmental Biology to a new generation. Several new modes of teaching are employed in the new Gilbert and Barresi textbook. The videos explaining development--as well as those from Mary Tyler's Vade Mecum--are referenced throughout the book, and several other valuable new elements have been added.