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Diagnostics and Gene Therapy for Human Genetic Disorders
by K.V. ChaitanyaDiagnostics and Gene Therapy for Human Genetic Disorders provides an integrative and comprehensive source of information blending classical human genetics with the human genome. It provides a multidisciplinary overview of Mendelian inheritance and multifactorial inheritance, genetic variations, polymorphisms, chromosomal, multifactorial, and mitochondrial disorders. PCR, electrophoresis, cytogenetics, prenatal, and HPLC based techniques applied for diagnosing genetic disorders are discussed with applications. Symptoms, etiology, diagnosis, treatment of 14 major and 5 minor genetic disorders are discussed in detail. Methods employed for the preparation of kits for the diagnosis of diseases are provided. The role of gene therapy in the amelioration of genetic disorders and the methodology employed are discussed. The success of gene therapy in controlling various disorders such as immune system disorders, neurodegenerative disorders, cardiovascular disorders, eye diseases, and cancer has been described along with type studies. Features: A blend of classical human genetics with molecular and genome-based applications Techniques applied for the diagnosis of genetic disorders Diagnostics of 19 genetic disorders including symptoms, etiology, diagnosis, and treatment Role of gene therapy in the amelioration of disorders Type studies describing the role of diagnostics in conserving the human health This book attempts to connect all the information about classical and modern human genetics, genetic disorders, and gene therapy to all types of diseases in one place. This work provides a comprehensive source of information that can serve as a reference book for scientific investigations and as a textbook for the graduate students.
Diagnostics in Ocular Imaging: Cornea, Retina, Glaucoma and Orbit
by Mehrdad MohammadpourThis book presents a new avenue in the field of ophthalmology and sheds light on the field of eye imaging. With the increasing availability of electronic devices and their important role in both personal and professional aspects of human life, there is a growing need for perfect vision. Ophthalmic imaging is a major tool for screening and documenting eye diseases in both medical and surgical fields of ophthalmology and is also of use for ophthalmologists around the globe. The number of eye-imaging devices has increased dramatically, however undiagnosed or poorly managed eye diseases remain a significant cause of ocular and visual problems worldwide. This essential guide addresses the need for a book that is dedicated to ophthalmic imaging, covering the cornea, glaucoma, retina and orbital imaging with updates on medical and surgical aspects of the topic.
Diagnostics in Plant Breeding
by Rajeev Varshney Thomas Lübberstedt"Diagnostics in Plant Breeding" is systematically organizing cutting-edge research reviews on the development and application of molecular tools for the prediction of plant performance. Given its significance for mankind and the available research resources, medical sciences are leading the area of molecular diagnostics, where DNA-based risk assessments for various diseases and biomarkers to determine their onset become increasingly available. So far, most research in plant genomics has been directed towards understanding the molecular basis of biological processes or phenotypic traits. From a plant breeding perspective, however, the main interest is in predicting optimal genotypes based on molecular information for more time- and cost-efficient breeding schemes. It is anticipated that progress in plant genomics and in particular sequence technology made recently will shift the focus from "explanatory" to "predictive" in crop science. This book assembles chapters on all areas relevant to development and application of predictive molecular tools in plant breeding by leading authorties in the respective areas.
Diagrammatica
by Martinus VeltmanThis author provides an easily accessible introduction to quantum field theory via Feynman rules and calculations in particle physics. His aim is to make clear what the physical foundations of present-day field theory are, to clarify the physical content of Feynman rules. The book begins with a brief review of some aspects of Einstein's theory of relativity that are of particular importance for field theory, before going on to consider the relativistic quantum mechanics of free particles, interacting fields, and particles with spin. The techniques learnt in the chapters are then demonstrated in examples that might be encountered in real accelerator physics. Further chapters contain discussions of renormalization, massive and massless vector fields and unitarity. A final chapter presents concluding arguments concerning quantum electrodynamics. The book includes valuable appendices that review some essential mathematics, including complex spaces, matrices, the CBH equation, traces and dimensional regularization. An appendix containing a comprehensive summary of the rules and conventions used is followed by an appendix specifying the full Lagrangian of the Standard Model and the corresponding Feynman rules. To make the book useful for a wide audience a final appendix provides a discussion of the metric used, and an easy-to-use dictionary connecting equations written with different metrics. Written as a textbook, many diagrams, exercises and examples are included. This book will be used by beginning graduate students taking courses in particle physics or quantum field theory, as well as by researchers as a source and reference book on Feynman diagrams and rules.
Dial B for Birder: Private Files of a Real Life Bird Detective
by Lola Oberman[From the back cover:] "When Lola Oberman's telephone rings, expect a mystery. What was that "huge, six-foot bird" that a worried motorist spotted standing by the roadside? Who or what is murdering hapless wood ducks on the Mississippi Flyway? And what kind of bird was the brash creature that interrupted the President's speech at the White House with its loud, melodious outbursts? Dial B for Birder is a collection of such mysteries. As a telephone bird identifier for the Audubon Naturalist Society, author Lola Oberman has become the Jessica Fletcher of birders--an authority who can "name that bird in five minutes." If you've ever been baffled by a colorful bird in your back yard, you'll be fascinated as the author wrestles clues from her callers and goes on to solve birding mysteries large and small. In 1976, Lola Oberman left the world of national politics (she was a speechwriter and political aide) for the world of birds. She is contributing editor to Bird Watcher's Digest, and her popular birdwatching column, "Notes from Melody Lane," appears in Audubon Naturalist News. Her first book, The Pleasures of Watching Birds, has been endorsed by the father of modern birding, Roger Tory Peterson. Dial B for Birder is a book like no other. For lovers of birds--or lovers of mysteries--it will become a thumb-worn classic and a permanent fixture on the old-favorites bookshelf." For anyone lacking the visual acuity to see birds, this book provides descriptions of the appearance and behavior of well known and lesser known birds that are so vivid the reader will feel convinced they have had the pleasurable experience of actually seeing the marvelous sight of birds from house sparrows to baby hummingbirds, from gulls to wood ducks, from crows to grackles and from snowy owls to red tailed hawks, and many, many more.
Dialogic Collaborative Action Research in Science Education: Collaborative Conversations for Improving Science Teaching and Learning (ISSN)
by Allan Feldman Jawaher Alsultan Katie Laux Molly NationThis engaging and practical book offers science teacher educators and K-12 science teachers alike the tools to engage in a dialogic mode of collaborative action research (D-CAR), a collaborative mode of action research focused on teachers’ experiences with students, reflection upon these experiences, and peer learning.Renowned science educator Allan Feldman and co-authors from across numerous settings in K-12 science education present the theory, methodology, case studies, and practical advice to support the use of D-CAR as a means to enhance teachers’ normal practice and address the problems, dilemmas, and dissonances that science teachers must negotiate as they work to meet the needs of an increasingly diverse student population and engage with complex science teaching challenges that disproportionately affect marginalized students.The book will be of use to science teacher educators, pre-service and in-service science teachers, professional development specialists, or any science educator invested in developing creative, reflective, and thoughtful teachers.
Dialogic Collaborative Action Research in Science Education: Collaborative Conversations for Improving Science Teaching and Learning (Teaching and Learning in Science Series)
by Allan Feldman Jawaher Alsultan Katie Laux Molly NationThis engaging and practical book offers science teacher educators and K-12 science teachers alike the tools to engage in a dialogic mode of collaborative action research (D-CAR), a collaborative mode of action research focused on teachers’ experiences with students, reflection upon these experiences, and peer learning. Renowned science educator Allan Feldman and co-authors from across numerous settings in K-12 science education present the theory, methodology, case studies, and practical advice to support the use of D-CAR as a means to enhance teachers’ normal practice and address the problems, dilemmas, and dissonances that science teachers must negotiate as they work to meet the needs of an increasingly diverse student population and engage with complex science teaching challenges that disproportionately affect marginalized students. The book will be of use to science teacher educators, pre-service and in-service science teachers, professional development specialists, or any science educator invested in developing creative, reflective, and thoughtful teachers.
Dialogic Education: Mastering core concepts through thinking together (Computer-Supported Collaborative Learning Series #7)
by Rupert Wegerif Neil PhillipsonDialogue has long been used in primary classrooms to stimulate thinking, but it is not always easy to unite the creative thinking of good dialogue with the need for children to understand the core concepts behind knowledge-rich subjects. A sound understanding of key concepts is essential to progress through the national curriculum, and assessment of this understanding along with effective feedback is central to good practice. Dialogic Education builds upon decades of practical classroom research to offer a method of teaching that applies the power of dialogue to achieving conceptual mastery. Easy-to-follow template lesson plans and activity ideas are provided, each of which has been tried and tested in classrooms and is known to succeed. Providing a structure for engaging children and creating an environment in which dialogue can flourish, this book is separated into three parts: Establishing a classroom culture of learning; Core concepts across the curriculum; Wider dialogues: Educational adventures in the conversation of mankind. Written to support all those in the field of primary education, this book will be an essential resource for student, trainee and qualified primary teachers interested in the educational importance of dialogue.
Dialogue Concerning the Two Chief World Systems: Ptolemaic and Copernican
by Stephen Jay Gould Stillman Drake GalileoGalileo's Dialogue Concerning the Two Chief World Systems, published in Florence in 1632, was the most proximate cause of his being brought to trial before the Inquisition. Using the dialogue form, a genre common in classical philosophical works, Galileo masterfully demonstrates the truth of the Copernican system over the Ptolemaic one, proving, for the first time, that the earth revolves around the sun. Its influence is incalculable. The Dialogue is not only one of the most important scientific treatises ever written, but a work of supreme clarity and accessibility, remaining as readable now as when it was first published. This edition uses the definitive text established by the University of California Press, in Stillman Drake's translation, and includes a Foreword by Albert Einstein and a new Introduction by J. L. Heilbron.
Dialogue and Dementia: Cognitive and Communicative Resources for Engagement
by Martin J. Ball Nicole Müller Robert W. Schrauf Jack S. DamicoThis volume takes the positive view that conversation between persons with dementia and their interlocutors is a privileged site for ongoing cognitive engagement. The book aims to identify and describe specific linguistic devices or strategies at the level of turn-by-turn talk that promote and extend conversation, and to explore real-world engagements that reflect these strategies. Final reflections tie these linguistic strategies and practices to wider issues of the "self" and "agency" in persons with dementia. Thematically, the volume fosters an integrated perspective on communication and cognition in terms of which communicative resources are recognized as cognitive resources, and communicative interaction is treated as reflecting cognitive engagement. This reflects perspectives in cognitive anthropology and cognitive science that regard human cognitive activity as distributed and culturally rooted. This volume is intended for academic researchers and advanced students in applied linguistics, linguistic and medical anthropology, nursing, and social gerontology; and practice professionals in speech-language pathology and geropsychology.
Dialogues Between Artistic Research and Science and Technology Studies (Routledge Advances in Art and Visual Studies)
by Trevor Pinch Peter Peters Henk BorgdorffThis edited volume maps dialogues between science and technology studies research on the arts and the emerging field of artistic research. The main themes in the book are an advanced understanding of discursivity and reasoning in arts-based research, the methodological relevance of material practices and things, and innovative ways of connecting, staging, and publishing research in art and academia. This book touches on topics including studies of artistic practices; reflexive practitioners at the boundaries between the arts, science, and technology; non-propositional forms of reasoning; unconventional (arts-based) research methods and enhanced modes of presentation and publication.
Dialogues Concerning Natural Religion
by David HumeHow can we know that God exists? Is it possible to find proof of religion's most significant issues? Can we presume that the orderliness of the universe offers evidence of a purposeful creator? David Hume's Dialogues Concerning Natural Religion explores these perennial questions in a thought-provoking and highly readable style.This classic examines its controversial subject in the well-known manner of the Platonic dialogues. Hume's characters discuss God's existence, his divinity and attributes, and the reasons behind his creation of the world. In clear, evocative prose, the debate's participants state and defend their positions, most of which center on the concept currently known as Intelligent Design. Hume's intense skepticism provides ingenious, persuasive refutations of the notion that reason and logic provide support for religious dogma. A work of historical importance as well as of ongoing relevance to modern life, this volume endures as both an inspiring philosophical inquiry and a literary gem.
Dialogues on Ethical Vegetarianism (Philosophical Dialogues on Contemporary Problems)
by Michael HuemerWorldwide every year, 83 billion animals are slaughtered on factory farms, at the end of brief lives full of suffering. Is it wrong to buy the products of this industry?In this book, two college students – a meat-eater and an ethical vegetarian – discuss this question in a series of dialogues conducted over five days. Issues covered include: how intelligence affects the badness of pain, whether consumers are responsible for the practices of the industry, how individual choices affect an industry, whether farm animals are better off living on factory farms than not existing at all, whether meat-eating is natural, whether morality protects those who cannot understand morality, whether morality protects those who are not members of society, whether humans alone possess souls, whether different creatures have different degrees of consciousness, why extreme animal welfare positions "sound crazy," and the role of empathy in moral judgment. The two go on to discuss the vegan life, why people who accept the arguments often fail to change their behavior, and how vegans should interact with non-vegans.This Second Edition also covers many new topics, including: Satisfying nutritional needs with plant-based foods The overall health effects of vegetarian diets The consumer costs of a plant-based diet Synthetic meat Food deserts Christian-inspired arguments for and against veganism Progressive-inspired arguments for and against veganism A new appendix offers readers delicious vegan recipes, including ones for Carrot Ginger Soup, Avocado Toast, Compassionate Chili, and The Smoothie of the Gods. Key Features: Thoroughly reviews the common arguments on both sides of the debate Dialogue format provides the most engaging way of introducing the issues Written in clear, conversational prose for a popular audience Offers new insights into the psychology of our dietary choices and our responsibility for influencing others New in this edition, several easy and delicious vegan recipes
Dialogues on the Human Ape (Posthumanities)
by Laurent Dubreuil Sue Savage-RumbaughA primatologist and a humanist together explore the meaning of being a &“human animal&”Humanness is typically defined by our capacity for language and abstract thinking. Yet decades of research led by the primatologist Sue Savage-Rumbaugh has shown that chimpanzees and bonobos can acquire human language through signing and technology. Drawing on this research, Dialogues of the Human Ape brings Savage-Rumbaugh into conversation with the philosopher Laurent Dubreuil to explore the theoretical and practical dimensions of what being a &“human animal&” means. In their use of dialogue as the primary mode of philosophical and scientific inquiry, the authors transcend the rigidity of scientific and humanist discourses, offering a powerful model for the dissemination of speculative hypotheses and open-ended debates grounded in scientific research.Arguing that being human is an epigenetically driven process rather than a fixed characteristic rooted in genetics or culture, this book suggests that while humanness may not be possible in every species, it can emerge in certain supposedly nonhuman species. Moving beyond irrational critiques of ape consciousness that are motivated by arrogant, anthropocentric views, Dialogues on the Human Ape instead takes seriously the continuities between the ape mind and the human mind, addressing why language matters to consciousness, free will, and the formation of the &“human animal&” self.
Dialysis Access Cases
by Alexander S. Yevzlin Arif Asif Robert R. Redfield III Gerald A. BeathardMoving beyond the science of hemodialysis access, this collection of clinical cases covers procedural and practical aspects of arteriovenous fistula, arteriovenous graft, dialysis catheter, draining veins, central veins, arterial interventions and hand ischemia. World experts in the disciplines of interventional nephrology, interventional radiology and surgery offer creative visions of their practice and provide insights on topics from routine access creation to advanced novel techniques. Dialysis Access Cases presents solutions to problems encountered in practice while capturing the art of this medical discipline and challenging procedure.
Diameter-Transformed Fluidized Bed: Fundamentals and Practice (Particle Technology Series #27)
by Wei Wang Mingyuan He Youhao Xu Bona Lu Yujie TianThis book puts forward the concept of the Diameter-Transformed Fluidized Bed (DTFB): a fluidized bed characterized by the coexistence of multiple flow regimes and reaction zones, achieved by transforming the bed into several sections of different diameters. It reviews fundamental aspects, including computational fluid dynamics simulations and industrial practices in connection with DTFB. In particular, it highlights an example concerning the development of maximizing iso-paraffins (MIP) reactors for regulating complex, fluid catalytic cracking reactions in petroleum refineries. The book is a must-have for understanding how academic and industrial researchers are now collaborating in order to develop novel catalytic processes.
Diamond Electrodes: Fundamentals and Applications
by Yasuaki EinagaThis book introduces the recent development in Japan of diamond electrodes, which has attracted much attention in the world. For example, electrochemical sensors using diamond electrodes are now being utilized commercially. Newly developing applications such as electrochemical organic synthesis including CO2 reduction are also expected to form an important future technology. Those emerging applications to various fields which are receiving increasing attention are described in detail here.This book is useful not only for students who would like to begin their study of diamond electrodes but also for industries that are exploring novel electrochemical applications.
Diamond Films Handbook
by Jes Asmussen D. K. ReinhardThe Diamond Films Handbook is an important source of information for readers involved in the new diamond film technology, emphasizing synthesis technologies and diamond film applications. Containing over 1600 references, drawings, photographs, micrographs, equations, and tables, and contributions by experts from both industry and academia, it inclu
Diamond Turn Machining: Theory and Practice (Micro and Nanomanufacturing Series)
by R. Balasubramaniam RamaGopal V. Sarepaka Sathyan SubbiahThe goal of this book is to familiarize professionals, researchers, and students with the basics of the Diamond Turn Machining Technology and the various issues involved. The book provides a comprehensive knowledge about various aspects of the technology including the background, components of the machine, mechanism of material removal, application areas, relevant metrology, and advances taking place in this domain. Solved and unsolved examples are provided in each of the areas which will help the readers to practice and get familiarized with that particular area of the Diamond Turn Machining process.
Diamond and Related Nanostructures
by Csaba Levente Nagy Mircea Vasile DiudeaOver the past twenty years, the field of carbon structures has been invigorated by the discovery of fullerenes and carbon nanotubes. These nano-structured carbons have attracted a tremendous interest in the fundamental properties of discrete carbon molecules, leading to the discovery of novel complex crystalline and quasi-crystalline materials. As a consequence, a variety of applications have been developed, including technical and bio-medical materials and miniaturized tools. Diamond and Related Nanostructures focuses on the advances in the area of diamond-like carbon nanostructures (hyper-structures built from fullerenes and/or carbon nanotube junctions) and other related carbon nanostructures. Each chapter contributes to the topic from different fields, ranging from theory to synthesis and properties investigation of these new materials. This volume brings together the major findings in the field and provides a source of inspiration and understanding to advanced undergraduates, graduates, and researchers in the fields of Physics, Graph Theory, Crystallography, Computational and Synthetic Chemistry.
Diamond-Like Carbon Coatings: Technologies and Applications
by Suchart Siengchin Sanjay Mavinkere Rangappa Peerawatt Nunthavarawong Kuniaki DohdaDiamond-like carbons (DLCs) display a number of attractive properties that make them versatile coating materials for a variety of applications, including extremely high hardness values, very low friction properties, very low gas permeability, good biocompatibility, and very high electrical resistivity, among others. Further research into this material is required to produce hydrogen-free DLC films and to synthesize it together with other materials, thereby obtaining better film properties. Diamond-Like Carbon Coatings: Technologies and Applications examines emerging manufacturing technologies for DLCs with the aim of improving their properties for use in practical applications. Discusses DLC coatings used in mechanical, manufacturing, and medical applications Details recent developments in the novel synthesis of DLC films Covers advances in understanding of chemical, structural, physical, mechanical, and tribological properties for modern material processing Highlights methods to yield longer service life Considers prospects for future applications of emerging DLC technologies This work is aimed at materials science and engineering researchers, advanced students, and industry professionals.
Diamond: A Struggle for Environmental Justice in Louisiana's Chemical Corridor
by Robert D. Bullard Steve LernerFor years, the residents of Diamond, Louisiana, lived with an inescapable acrid, metallic smell -- the "toxic bouquet" of pollution -- and a mysterious chemical fog that seeped into their houses. They looked out on the massive Norco Industrial Complex: a maze of pipelines, stacks topped by flares burning off excess gas, and huge oil tankers moving up the Mississippi. They experienced headaches, stinging eyes, allergies, asthma, and other respiratory problems, skin disorders, and cancers that they were convinced were caused by their proximity to heavy industry. Periodic industrial explosions damaged their houses and killed some of their neighbors. Their small, African-American, mixed-income neighborhood was sandwiched between two giant Shell Oil plants in Louisiana's notorious Chemical Corridor. When the residents of Diamond demanded that Shell relocate them, their chances of success seemed slim: a community with little political clout was taking on the second-largest oil company in the world. And yet, after effective grassroots organizing, unremitting fenceline protests, seemingly endless negotiations with Shell officials, and intense media coverage, the people of Diamond finally got what they wanted: money from Shell to help them relocate out of harm's way. In this book, Steve Lerner tells their story. Around the United States, struggles for environmental justice such as the one in Diamond are the new front lines of both the civil rights and the environmental movements, and Diamond is in many ways a classic environmental-justice story: a minority neighborhood, faced with a polluting industry in its midst, fights back. But Diamond is also the history of a black community that goes back to the days of slavery. In 1811, Diamond (then the Trepagnier Plantation) was the center of the largest slave rebellion in United States history. Descendants of these slaves were among the participants in the modern-day Diamond relocation campaign. Steve Lerner talks to the people of Diamond, and lets them tell their story in their own words. He talks also to the residents of a nearby white neighborhood -- many of whom work for Shell and have fewer complaints about the plants -- and to environmental activists and Shell officials. His account of Diamond's 30-year ordeal puts a human face on the struggle for environmental justice in the United States.
Diamonds of Doom (Escape from Planet Alcatraz)
by Michael DahlTraveling by night, Zak Nine and Erro are following a shadowy figure until the mysterious stranger disappears into a cave. The boys decide to follow. Inside they find a maze filled with priceless gems, along with a rough band of escaped criminals. Things go from bad to worse when a squad of Alcatraz guards arrives on the scene. When the guards start shooting their laser blasters, suddenly nobody is safe! Will Zak and Erro escape the deadly storm of laser fire, or will they be trapped in the endless dark forever?
Diamonds: An Early History of the King of Gems
by Jack OgdenA lavishly illustrated, in-depth early history covering two thousand years of diamond jewelry and commerce, from the Indian mines to European merchants, courts, and workshops This richly illustrated history of diamonds illuminates myriad facets of the “king of gems,” including a cast of larger-than-life characters such as Alexander the Great, the Mughal emperor Jahangir, and East India Company adventurers. It’s an in-depth study tracing the story of diamonds from their early mining and trade more than two thousand years ago to the 1700s, when Brazil displaced India as the world’s primary diamond supplier. Jack Ogden, a historian and gemologist specializing in ancient gems and jewelry, describes the early history of diamond jewelry, the development of diamond cutting, and how diamonds were assessed and valued. The book includes more than one hundred captivating images, from close-up full-color photographs of historic diamond-set jewelry (some previously unpublished), to photomicrographs of individual gems and illustrations of medieval manuscripts, as well as diagrams depicting historical methods of cutting and polishing diamonds.