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Dietary Phytochemicals and Microbes

Humans have utilized the bioactive principles of different plants for various beneficial physiological properties including antimicrobial properties for many centuries. However, interests of using medicinal plants declined in the 20th century with the availability of effective synthetic antimicrobial drugs. The development of microbial resistance to various drugs has accelerated research interests towards the use of phytochemicals as alternatives to synthetic drugs in the recent years. This book presents an comprehensive reviews on the antimicrobial and antiviral properties of numerous recently reported phytochemicals, and their mechanisms of antimicrobial actions. Some of the chapters have critically discussed the beneficial and adverse effects of antibacterial, and stimulatory activities of dietary phytochemicals on rumen microbial populations, and gut microbial populations of humans and animals. Microbial adaptation and resistance of microbes to phytochemicals has also been highlighted. On the applied apects, the use of phytochemicals against drug resistance microbes, to treat microbial diseases, for food preservation, to inhibit methanogenic archaea in the rumen, and to modulate lipid biohydrogenating microbial populations to increase conjugated linoleic acids in animal-derived foods have been presented in different chapters.

Dietary Polyphenols in Human Diseases: Advances and Challenges in Drug Discovery

Diets rich in plant polyphenols or dietary polyphenols are the subject of increasing scientific interest because of their diverse range of health benefits and medicinal uses. This book, Dietary Polyphenols in Human Diseases: Advances and Challenges in Drug Discovery, fills the gap that exists in the current knowledge by presenting the latest information in the area of polyphenol-based drug discovery research. The book focuses on the current understanding of the beneficial effects on human health of diets rich in polyphenols and/or polyphenolic compounds derived from dietary sources (plant-based foods) and their possible preventive role in the management of chronic human diseases. In addition, biochemical mechanisms involved in the antioxidative effect of dietary polyphenols along with their bioavailability, pharmacokinetic, and toxicological considerations are also discussed herein. Key Features Presents health benefits and medicinal importance of dietary polyphenols having antioxidative effects and their possible preventive role against oxidative stress (OS)-induced chronic human diseases. Summarizes the latest understanding of the biochemical mechanism(s) involved in the antioxidative action of dietary polyphenols along with their bioavailability, pharmacokinetic, and toxicological considerations. Highlights novel approaches of drug discovery from dietary polyphenols through computational screening of bioactive phytochemical components. With contributions by a global team of experts (academics, scientists, and researchers), this book is intended to be a useful resource for a wider audience, particularly those working in the area of drug discovery and development research, such as discovery scientists, pharmaceutical scientists (R&D), formulation scientists, medicinal chemists, pharmacologists, toxicologists, phytochemists, biochemists, clinicians, researchers, students, teachers, and many others.

Dietary Reference Intakes for Sodium and Potassium (Dietary Reference Intakes Ser.)

As essential nutrients, sodium and potassium contribute to the fundamentals of physiology and pathology of human health and disease. In clinical settings, these are two important blood electrolytes, are frequently measured and influence care decisions. Yet, blood electrolyte concentrations are usually not influenced by dietary intake, as kidney and hormone systems carefully regulate blood values. Over the years, increasing evidence suggests that sodium and potassium intake patterns of children and adults influence long-term population health mostly through complex relationships among dietary intake, blood pressure and cardiovascular health. The public health importance of understanding these relationships, based upon the best available evidence and establishing recommendations to support the development of population clinical practice guidelines and medical care of patients is clear. This report reviews evidence on the relationship between sodium and potassium intakes and indicators of adequacy, toxicity, and chronic disease. It updates the Dietary Reference Intakes (DRIs) using an expanded DRI model that includes consideration of chronic disease endpoints, and outlines research gaps to address the uncertainties identified in the process of deriving the reference values and evaluating public health implications.

Dietary Reference Intakes for Water, Potassium, Sodium, Chloride, and Sulfate

The Dietary Reference Intakes (DRIs) are quantitative estimates of nutrient intakes to be used for planning and assessing diets for healthy people. This new report, the sixth in a series of reports presenting dietary reference values for the intakes of nutrients by Americans and Canadians, establishes nutrient recommendations on water, potassium, and salt for health maintenance and the reduction of chronic disease risk. Dietary Reference Intakes for Water, Potassium, Sodium, Chloride, and Sulfate discusses in detail the role of water, potassium, salt, chloride, and sulfate in human physiology and health. The major findings in this book include the establishment of Adequate Intakes for total water (drinking water, beverages, and food), potassium, sodium, and chloride and the establishment of Tolerable Upper Intake levels for sodium and chloride. The book makes research recommendations for information needed to advance the understanding of human requirements for water and electrolytes, as well as adverse effects associated with the intake of excessive amounts of water, sodium, chloride, potassium, and sulfate. This book will be an invaluable reference for nutritionists, nutrition researchers, and food manufacturers.

Dietary Research and Cancer

This book reviews all important aspects of dietary research associated with cancer with the aim of shedding new light on these conditions through combined understanding of traditional and new paradigms. The book is divided into 17 chapters, the first portion reinterprets healthy diets for cancer based on up-to-date evidence from a network science perspective, examining the dietary patterns, outcome of diet related clinical trials, emerging framework of molecular mechanisms and interactions of dietary interventions and their applications in personalized diet, ground realities of benefits and regulatory frame work for functional foods, nutraceuticals and supplements in cancer prevention and upcoming future prospectus in diet-cancer research.. The later part of the book discusses recent advances in understanding of the elaborative discourse on cancer and fasting, covering, for example, calorie restriction and fasting mimicking diet. Finally, different Dietary research and approaches are considered in the context of novel intervention for cancer research. Dietary Research in Cancer will be of interest for all researchers, nutritionists, students and clinicians in the field.

Dietary Supplement Good Manufacturing Practices: Preparing for Compliance

Dietary Supplement GMP is a one-stop "how-to" road map to the final dietary supplement GMP regulations recently issued by the FDA covering the manufacture, packaging, and holding of dietary supplement products.The recent regulations, outlining broad goals, intentionally avoid specifics to allow for future technological advances-leaving implementati

Dietary Supplementation in Sport and Exercise: Evidence, Safety and Ergogenic Benefits

Dietary Supplementation in Sport and Exercise removes the myths associated with many dietary supplements. It provides an evidence-based approach to the physiological mechanisms related to popular supplements and examines the ergogenic benefits in both competitive and recreational athletes. <P><P> This text covers a variety of supplements, including vitamins and minerals, carbohydrates, protein and amino acids, beta-alanine, creatine and guanidinoacetic acid, caffeine and probiotics, as well as emerging ergogenic aids. Information on dosage, ceiling effects and washout periods is discussed, along with safety and legality for different sporting organizations. The book also offers an insight into the efficacy of certain dietary supplements in unique populations, like children and the elderly. Dietary Supplementation in Sport and Exercise is an important resource for advanced undergraduate and graduate students on exercise science, health and nutrition courses, as well as strength coaches, athletic trainers, nutritionists and personal trainers, and medical professionals who consult with patients on dietary supplementation.

Dietary Supplements of Plant Origin: A Nutrition and Health Approach

Dietary supplements are estimated to be used regularly by almost 60% of the American population, and over 300 million people worldwide. An important and ever-growing portion of this market is in botanical supplements that are derived from natural plants. Natural, however, does not necessarily mean safe, and although plants can provide health-essent

Dieter Senghaas

Dieter Senghaas, professor emeritus of international relations, University of Bremen, was one of most innovative contemporary German social scientists, with major contributions on peace and development research and on music and peace. He was awarded many prizes: the International Peace Research Award (1987), Göttingen Peace Prize (1999), Culture and Peace Prize of the Villa Ichon in Bremen (2006), and the Leopold-Kohr Prize of the Austrian Ministry of Science and Research (2010). In addition to his autobiographic notes and his selected bibliography, this book offers a global audience five key texts by D. Senghaas (1974-2009): Towards an Analysis of Threat Policy in International Relations; Friedrich List and the Basic Problems of Development; Developing the Definitions of Perpetual Peace ('para pacem'): Through What and How is Peace Constituted Today?; Sounds of Peace: On Peace Fantasies and Peace Offerings in Classical Music; and Enhancing Human Rights - A Contribution to Viable Peace.

Difference Gel Electrophoresis

This volume provides a comprehensive study of this key method of gel-based proteomics. Chapters in Difference Gel Electrophoresis: Methods and Protocols detail methods on principles of differential protein labeling, two-dimensional gel electrophoresis, techniques on optimized proteomic workflows, advanced mass spectrometry for protein identification, application of basic biological research, and applied biomarker discovery. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Difference Gel Electrophoresis: Methods and Protocols aims to ensure successful results in the further study of this vital field.

Difference Gel Electrophoresis: Methods and Protocols (Methods in Molecular Biology #2596)

The second edition of this volume provides a comprehensive update of this key method on gel-based proteomics. Chapters present an introduction into the development of methods on principles of differential protein labeling and two-dimensional gel electrophoresis, techniques on optimized proteomic workflows using advanced mass spectrometry for protein identification, and the application of those methods in basic biological research, pathobiology and applied biomarker discovery. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Difference Gel Electrophoresis: Methods and Protocols, Second Edition aims to ensure successful results in the further study of this vital field.

Difference Gel Electrophoresis (DIGE)

Protein analysis is increasingly becoming a cornerstone in deciphering the molecular mechanisms of life. Proteomics, the large-scale and high-sensitivity analysis of proteins, is already pivotal to the new life sciences such as Systems Biology and Systems Medicine. Proteomics, however, relies heavily on the past and future advances of protein purification and analysis methods. DIGE, being able to quantify proteins in their intact form, is one of a few methods that can facilitate this type of analysis and still provide the protein isoforms in an MS-compatible state for further identification and characterization with high analytical sensitivity. Differential Gel Electrophoresis: Methods and Protocols introduces the concept of DIGE and its advantages in quantitative protein analysis. It provides detailed protocols and important notes on the practical aspects of DIGE with both generic and specific applications in the various areas of Quantitative Proteomics. Divided into four concise sections, this detailed volume opens with the basics of DIGE, the technique and its practical details with a focus on the planning of a DIGE experiment and its data analysis. The next section introduces various DIGE methods from those employed by scientists world-wide to more novel methods, providing a glance at what is on the horizon in the DIGE world. The volume closes with an overview of the wide range of DIGE applications from Clinical Proteomics to Animal, Plant, and Microbial Proteomics applications. Written in the highly successful Methods in Molecular BiologyTM series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Differential Gel Electrophoresis: Methods and Protocols can be used by novices with some background in biochemistry or molecular biology as well as by experts in Proteomics who would like to deepen their understanding of DIGE and its employment in many hyphenations and application areas. With its many protocols, applications, and methodological variants, it is also a unique reference for all who seek fundamental details on the working principle of DIGE and ideas for possible future uses of DIGE in novel analytical approaches.

Difference, Sameness and DNA: Investigations in Critical Art and Science (Palgrave BioArt)

This book chronicles over two decades of critical, artistic investigations by Paul Vanouse. His bio-media artwork utilizes the tools of the life sciences reflexively, to challenge tropes and cultural politics surrounding DNA, biotechnology, and life itself. DNA has been called a “Truth Machine”, “God’s Blueprint”, the “Code of Codes” and the “Book of Life”. Vanouse’s work explores questions at the heart of such evocative metaphor and hyperbole: how does DNA link us together, how does it differentiate us and how are the grand metaphors, which grant DNA complete centrality, misconstruing the complexity of life. Furthermore, how do technologies of genetic typing and identification fit within a broader cultural and political history of difference making, particularly the construction of race. Melding critical theory, artist’s manifesto, participatory observation and histories of the sciences, this book offers insight into both an artistic practice and the bio-techno-sciences it interrogates.

Different: Gender Through The Eyes Of A Primatologist

Longlisted for the PEN/E.O. Wilson Literary Science Writing Award "Every new book by Frans de Waal is a cause for excitement, and this one is no different. A breath of fresh air in the cramped debate about the differences between men and women. Fascinating, nuanced, and very timely." —Rutger Bregman, author of Humankind: A Hopeful History In Different, world-renowned primatologist Frans de Waal draws on decades of observation and studies of both human and animal behavior to argue that despite the linkage between gender and biological sex, biology does not automatically support the traditional gender roles in human societies. While humans and other primates do share some behavioral differences, biology offers no justification for existing gender inequalities. Using chimpanzees and bonobos to illustrate this point—two ape relatives that are genetically equally close to humans—de Waal challenges widely held beliefs about masculinity and femininity, and common assumptions about authority, leadership, cooperation, competition, filial bonds, and sexual behavior. Chimpanzees are male-dominated and violent, while bonobos are female-dominated and peaceful. In both species, political power needs to be distinguished from physical dominance. Power is not limited to the males, and both sexes show true leadership capacities. Different is a fresh and thought-provoking approach to the long-running debate about the balance between nature and nurture, and where sex and gender roles fit in. De Waal peppers his discussion with details from his own life—a Dutch childhood in a family of six boys, his marriage to a French woman with a different orientation toward gender, and decades of academic turf wars over outdated scientific theories that have proven hard to dislodge from public discourse. He discusses sexual orientation, gender identity, and the limitations of the gender binary, exceptions to which are also found in other primates. With humor, clarity, and compassion, Different seeks to broaden the conversation about human gender dynamics by promoting an inclusive model that embraces differences, rather than negating them.

The Different Forms of Flowers on Plants of the Same Species

A Different Kind of Animal: How Culture Transformed Our Species

How our ability to learn from each other has been the essential ingredient to our remarkable success as a speciesHuman beings are a very different kind of animal. We have evolved to become the most dominant species on Earth. We have a larger geographical range and process more energy than any other creature alive. This astonishing transformation is usually explained in terms of cognitive ability—people are just smarter than all the rest. But in this compelling book, Robert Boyd argues that culture—our ability to learn from each other—has been the essential ingredient of our remarkable success.A Different Kind of Animal demonstrates that while people are smart, we are not nearly smart enough to have solved the vast array of problems that confronted our species as it spread across the globe. Over the past two million years, culture has evolved to enable human populations to accumulate superb local adaptations that no individual could ever have invented on their own. It has also made possible the evolution of social norms that allow humans to make common cause with large groups of unrelated individuals, a kind of society not seen anywhere else in nature. This unique combination of cultural adaptation and large-scale cooperation has transformed our species and assured our survival—making us the different kind of animal we are today.Based on the Tanner Lectures delivered at Princeton University, A Different Kind of Animal features challenging responses by biologist H. Allen Orr, philosopher Kim Sterelny, economist Paul Seabright, and evolutionary anthropologist Ruth Mace, as well as an introduction by Stephen Macedo.

A Different Perspective After Brain Injury: A Tilted Point of View (After Brain Injury: Survivor Stories)

Whilst preparing for his travel adventures into a world he had yet to explore, Christopher Yeoh was involved in a road traffic accident and experienced something few others would be "privileged" to witness. Eight days in a coma, more than a year in and out of hospital and a gradual re-introduction to the world of work. A Different Perspective After Brain Injury: A Tilted Point of View is written entirely by the survivor, providing an unusually introspective and critical personal account of life following a serious blow to the head. It charts the initial insult, early rehabilitation, development of understanding, the return of emotion, moments of triumph and regression into depression, the exercise of reframing how a brain injury is perceived and a return to work. It also describes the mental adjustments of awareness and acceptance alongside the physical recovery process. Readily accessible to the general public, this book will also be of particular interest to professionals involved in the care of people who have had significant brain injuries, brain injury survivors, their families and friends and also those who fund and organise health and social care. This unique author account will provide a degree of understanding of what living with a hidden disability is really like.

Different Perspectives in Design Thinking

Globalization and digitalization are buzz words in contemporary society. They affect both our private and our professional lives. Society has become more diverse with easier access to information and to virtual platforms that gives us opportunity to be in touch with colleagues, friends, family, etc. at any time. A complex environment is emerging wherein internet of things and big data are being integrated with products, production systems, healthcare, and daily activity and play an important part in decision making. This has an impact on future designs and the role of designers. Responsible designers with a holistic perspective are needed.The book highlights several aspects of design thinking such as Information Design and Critical Design. The meaning of culture, gender and disabilities are also discussed. The functions of Information Design are changing from ‘showing the way’, instruction manuals and graphic design. It will affect among others, healthcare technology, smart products and Industry 4.0. Design thinking perspective that includes users from the entire chain and from the producer to the end user of the product or service, is needed. This will also require gender and culture issues to be taken into consideration in designing products and services. Design thinking methods and critical aspects of design will contribute to an inclusive society.

A Different Universe: Reinventing Physics From the Bottom Down

In this age of superstring theories and Big Bang cosmology, we're used to thinking of the unknown as impossibly distant from our everyday lives. But in A Different Universe, Nobel Laureate Robert Laughlin argues that the scientific frontier is right under our fingers. Instead of looking for ultimate theories, Laughlin considers the world of emergent properties-meaning the properties, such as the hardness and shape of a crystal, that result from the organization of large numbers of atoms. Laughlin shows us how the most fundamental laws of physics are in fact emergent. A Different Universe is a truly mind-bending book that shows us why everything we think about fundamental physical laws needs to change.

Differentiable Manifolds

This textbook delves into the theory behind differentiable manifolds while exploring various physics applications along the way. Included throughout the book are a collection of exercises of varying degrees of difficulty. Differentiable Manifolds is intended for graduate students and researchers interested in a theoretical physics approach to the subject. Prerequisites include multivariable calculus, linear algebra, and differential equations and a basic knowledge of analytical mechanics.

Differentiable Manifolds: A Theoretical Physics Approach

This textbook delves into the theory behind differentiable manifolds while exploring various physics applications along the way. Included throughout the book are a collection of exercises of varying degrees of difficulty. Differentiable Manifolds is intended for graduate students and researchers interested in a theoretical physics approach to the subject. Prerequisites include multivariable calculus, linear algebra, and differential equations and a basic knowledge of analytical mechanics.

Differential and Differential-Algebraic Systems for the Chemical Engineer

This fourth in a suite of five practical guides is an engineer's companion to using numerical methods for the solution of complex mathematical problems. It explains the theory behind current numerical methods and shows in a step-by-step fashion how to use them.The volume focuses on differential and differential-algebraic systems, providing numerous real-life industrial case studies to illustrate this complex topic. It describes the methods, innovative techniques and strategies that are all implemented in a freely available toolbox called BzzMath, which is developed and maintained by the authors and provides up-to-date software tools for all the methods described in the book. Numerous examples, sample codes, programs and applications are taken from a wide range of scientific and engineering fields, such as chemical engineering, electrical engineering, physics, medicine, and environmental science. As a result, engineers and scientists learn how to optimize processes even before entering the laboratory.With additional online material including the latest version of BzzMath Library, installation tutorial, all examples and sample codes used in the book and a host of further examples.

Differential Display Methods and Protocols

Drs. Peng Liang and Arthur B. Pardee assemble for the first time a comprehensive review of the state of the art of their powerful new methodology and practical applications. The book's pioneering contributors describe all the major elements of this novel technology, including both RAP-PCR and DD using fluorescence detection, as well as their powerful strategy for identifying and cloning family-specific genes. They also provide numerous examples in which differentially expressed genes were successfully identified in diverse biological systems ranging from plants to songbirds to humans.

Differential Display Methods and Protocols

Based on a new mathematical model of differential display (DD), this updated second edition takes advantage of automation, as well as digital data acquisition and analysis. The authors explain and highlight all the recent methodological refinements, including automated liquid handling of hundreds of DD PCR reaction setups combined with capillary electrophoresis, a prototype computer program to automatically allow positive band identification from a fluorescence differential display (FD) image, and restriction fragment-based DD screenings. Other improvements discussed are the combining of DD and DNA microarrays by reducing the complexity of cDNA probes while increasing the sensitivity of detection, and a DD approach to detect prokaryotic mRNA expression. The authors also demonstrate the power of DD technology with a collection of outstanding examples of DD applications and detailed experimental procedures. The elegant studies described here have led to the discovery of many important genes involved in viral infection, Prion disease, cancer, ovulation, circadian clock, floral color, transcription repression gene silencing, mRNA polymorphism, and protein-RNA interaction.

Differential Equation Analysis in Biomedical Science and Engineering

Features a solid foundation of mathematical and computational tools to formulate and solve real-world PDE problems across various fieldsWith a step-by-step approach to solving partial differential equations (PDEs), Differential Equation Analysis in Biomedical Science and Engineering: Partial Differential Equation Applications with R successfully applies computational techniques for solving real-world PDE problems that are found in a variety of fields, including chemistry, physics, biology, and physiology. The book provides readers with the necessary knowledge to reproduce and extend the computed numerical solutions and is a valuable resource for dealing with a broad class of linear and nonlinear partial differential equations.The author's primary focus is on models expressed as systems of PDEs, which generally result from including spatial effects so that the PDE dependent variables are functions of both space and time, unlike ordinary differential equation (ODE) systems that pertain to time only. As such, the book emphasizes details of the numerical algorithms and how the solutions were computed. Featuring computer-based mathematical models for solving real-world problems in the biological and biomedical sciences and engineering, the book also includes:R routines to facilitate the immediate use of computation for solving differential equation problems without having to first learn the basic concepts of numerical analysis and programming for PDEsModels as systems of PDEs and associated initial and boundary conditions with explanations of the associated chemistry, physics, biology, and physiologyNumerical solutions of the presented model equations with a discussion of the important features of the solutionsAspects of general PDE computation through various biomedical science and engineering applicationsDifferential Equation Analysis in Biomedical Science and Engineering: Partial Differential Equation Applications with R is an excellent reference for researchers, scientists, clinicians, medical researchers, engineers, statisticians, epidemiologists, and pharmacokineticists who are interested in both clinical applications and interpretation of experimental data with mathematical models in order to efficiently solve the associated differential equations. The book is also useful as a textbook for graduate-level courses in mathematics, biomedical science and engineering, biology, biophysics, biochemistry, medicine, and engineering.