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Domino and Intramolecular Rearrangement Reactions as Advanced Synthetic Methods in Glycoscience
by Zbigniew J. Witczak Roman BielskiThe book consists of a brief introduction, a foreward provided by professor Danishefsky of Columbia University, and about 14 - 16 chapters, each written by one or two eminent scholars/authors describing their recent research in the area of either domino reactions or intramolecular rearrangements in carbohydrate chemistry. Three or four chapters will be reviews. The domino (cascade, tandem) reactions are always intramolecular. They are usually very fast, clean and offer highly complex structures in a one pot process. Intramolecular rearrangements offer very similar advantages and often lead to highly complex products as well. Although many recently isolated carbohydrates fulfill various sophisticated functions, their structures are often very complex. The editors cover the broadest scope of novel methodologies possible. All the synthetic and application aspects of domino/cascade reactions are explored in this book. A second theme that will be covered is intramolecular rearrangement, which is also fast, stereoselective, and often constitutes one or more steps of domino /cascade process. Selected examples of intramolecular rearrangements are presented. Together, both processes offer an elegant and convenient approach to the synthesis of many complex molecules, which are normally difficult to synthesize via alternative routes. It appears that domino and intramolecular rearrangements are ideally suited to synthesize certain specific modified monosaccharides. What is particularly important is that both processes are intermolecular and almost always yield products with very well-defined stereochemistry. This high definition is absolutely crucial when synthesizing advanced, modified mono and oligosaccharides. The choice of contributors reflects an emphasis on both therapeutic and pharmacological aspects of carbohydrate chemistry.
Domino Reactions
by Lutz F. TietzeThe follow-up to the successful "Domino Reaction in Organic Synthesis", this ready reference brings up to date on the original concept. The chapters have been arranged according to the name of well-known transformations of the first step and in combination with the formed products. Each chapter is written by an internationally renowned expert, and the book is edited by L. F. Tietze, who established the concept of domino reactions.The one-stop source for all synthetic chemists to improve the synthetic efficiency and allow an ecologically and economically beneficial preparation of every chemical compound.
¿Dónde viven los animales?: Animales asombrosos y sus extraordinarios hábitats (Journey Through)
by Derek Harvey13 hábitats extraordinarios, 13 historias inolvidablesDonde viven los animales te invita a recorrer los continentes en busca de los animales que los habitan. No pierdas el rastro al águila americana mientras surca majestuosamente los picos de las Montañas Rocosas; sigue la migración del ñu africano a través del parque nacional Serengueti mientras trata de cruzar peligrosos ríos bajo la mirada atenta de hambrientos depredadores; sigue el rastro del solitario leopardo del Amur (el felino más extraño del planeta) mientras acecha silenciosamente a su presa a través de los helados bosques de Siberia.Entrañables imágenes invitan al lector a sumergirse en cada página. Las inolvidables historias en el texto narrativo le animan a pasar las páginas. Pequeñas unidades de texto informativo se aseguran de que el lector aprende mientras se divierte.Donde viven los animales es un regalo ideal para niños de 4 a 8 años amantes de la naturaleza y la ecología, así como para inspirarles en su tareas escolares y a aprender de manera independiente en casa.
The Donkeys
by Alan ClarkThe landmark exposé of incompetent leadership on the Western Front - why the British troops were lions led by donkeys On 26 September 1915, twelve British battalions – a strength of almost 10,000 men – were ordered to attack German positions in France. In the three-and-a-half hours of the battle, they sustained 8,246 casualties. The Germans suffered no casualties at all. Why did the British Army fail so spectacularly? What can be said of the leadership of generals? And most importantly, could it have all been prevented? In The Donkeys, eminent military historian Alan Clark scrutinises the major battles of that fateful year and casts a steady and revealing light on those in High Command - French, Rawlinson, Watson and Haig among them - whose orders resulted in the virtual destruction of the old professional British Army. Clark paints a vivid and convincing picture of how brave soldiers, the lions, were essentially sent to their deaths by incompetent and indifferent officers – the donkeys. ‘An eloquent and painful book... Clark leaves the impression that vanity and stupidity were the main ingredients of the massacres of 1915. He writes searingly and unforgettably’ Evening Standard
Donnerwetter - Physik!
by Peter HäußlerJetzt als Sonderausgabe! Auf einer Geburtstagsparty werden Jugendlichen sieben Zauberkunststücke vorgeführt. Sieben erstaunliche Phänomene, die Anne und ihre Freunde zunächst vor Rätsel stellen. Doch so nach und nach kommen sie den Tricks auf die Spur. Mit der Unterstützung eines Nachbarn, einem pensionierten Physiker, entwickeln sie dazu physikalische Ideen: Anhand des Gewichts von Schokolade wird die Einheit für die Kraft diskutiert, "Schau mir in die Augen" leitet ein Gespräch über die Bildentstehung ein. Das Beobachten von Zugvögeln ist Aufhänger für den Magnetismus, und ein heftiges Gewitter gibt Anlass zum Nachdenken über die Elektrizität. Auch die von Physikern entwickelten Vorstellungen zu Quarks, Weißen Zwergen und Schwarzen Löchern kommen zur Sprache. Peter Häußler ist Professor für die Didaktik der Physik an der Universität Kiel und versteht es, lebendig und spannend zu schreiben. Über die Grundlagen der Physik hinaus erfährt der Leser auch etwas über ihre Erkenntnismethoden und den Unterschied zwischen Alltags- und Wissenschaftssprache. Alle Versuche sind genau beschrieben und können ohne großen Aufwand mit alltäglichen Gegenständen nachvollzogen werden. Das Buch ermutigt Jugendliche wie Erwachsene sich (wieder einmal) mit Physik zu beschäftigen, Kenntnisse aufzufrischen oder zu erweitern.
Donor-Acceptor Cyclopropanes in Organic Synthesis
by Prabal Banerjee Akkattu T. BijuDonor-Acceptor Cyclopropanes in Organic Synthesis Facilitate milder, simpler reactions in organic synthesis with this cutting-edge family of building blocks Donor-Accepted Cyclopropanes, or DACs, have attracted a resurgence of interest from organic chemists in recent decades for their role in facilitating various reactions such as cycloadditions, annulations, ring-opening and enantioselective transformations. The structural arrangement of DACs leads to milder, simpler reaction conditions, which have made them indispensable for a range of fundamentally and industrially important processes. Donor-Acceptor Cyclopropanes in Organic Synthesis covers comprehensively the chemistry and applications of this compound class. The result is an invaluable guide for any researcher looking to bring DACs to bear in their own areas of research or development. Readers will also find: A brief introduction of the history and reactivity of DACs Detailed discussion of reactions including Lewis acid-catalyzed cycloadditions, metal-free activation, asymmetric transformations, organocatalysis, and many more Application of DACs in natural product synthesis and pharmaceutical/agrochemical research Donor-Acceptor Cyclopropanes in Organic Synthesis is ideal for organic chemists, experts in catalysis, pharmaceutical researchers, and any other scientists interested in facilitating milder, simpler reactions.
#DoNotDisturb: How I Ghosted My Cell Phone to Take Back My Life
by Jedediah BilaHave you ever looked at your email, then texts, then Facebook, then Twitter, then email, then Instagram, then Candy Crush, then texts, then Snapchat, then texts again, and now you’ve wasted the time you had set aside for more important things? Jedediah Bila has solved her own Obsessive Compulsive Tech Disorder, and she did it without throwing away her devices.It's time to switch on airplane mode and settle into Jedediah Bila’s #DoNotDisturb: How I Ghosted My Cell Phone to Take Back My Life.In this timely, entertaining and inspiring book, Jedediah Bila chronicles her chaotic, confusing, and all-consuming love-hate relationship with - her cell phone. Stepping back from the whirlwind of texting, social media, and an endless sea of apps, Bila questions how our relationships, character, and sanity have suffered from our deep dive into the digital abyss. Exploring the toll that tech addiction took on her life, Bila reveals her missteps and mistakes, including several upending, life-altering months swirling in an ex-boyfriend’s cell-phone-enabled double life, and how a low-tech millennial later stole her heart.Travel with Jedediah through the embarrassing and catastrophic consequences of Ménage-a-Tech relationships, social media's Perception Deception, and the One-Potato-Chip-Problem of trying to resist Silicon Valley's hypnotic, slot-machine software designed to lure you in. Bila reveals how she navigated away from an unhealthy, oversaturated diet of tech junk food to striking just the right balance with technology to let her unplugged, real-life moments take charge. In #DoNotDisturb, Bila applies her trademark no-nonsense, common-sense, personal responsibility and accountability-centered approach, warning us that if we don’t stop acting like robots, our very humanity is at stake. Through warm anecdotes and cold, hard truths, Bila reveals how she pulled her way out of the tech fog to keep her eyes focused on the life right in front of her. And how you can too.
Don't Be Afraid of Physics: Quantum Mechanics, Relativity and Cosmology for Everyone
by Ross Barrett Pier Paolo DelsantoWith the aid of entertaining short stories, anecdotes, lucid explanations and straight-forward figures, this book challenges the perception that the world of physics is inaccessible to the non-expert. Beginning with Neanderthal man, it traces the evolution of human reason and understanding from paradoxes and optical illusions to gravitational waves, black holes and dark energy. On the way, it provides insights into the mind-boggling advances at the frontiers of physics and cosmology. Unsolved problems and contradictions are highlighted, and contentious issues in modern physics are discussed in a non-dogmatic way in a language comprehensible to the non-scientist. It has something for everyone.
Don't Be Such a Scientist: Talking Substance in an Age of Style
by Randy OlsonAfter nearly a decade on the defensive, the world of science is about to be restored to its rightful place. But is the American public really ready for science? And is the world of science ready for the American public? Scientists wear ragged clothes, forget to comb their hair, and speak in a language that even they don't understand. Or so people think. Most scientists don't care how they are perceived, but in our media-dominated age, style points count.Enter Randy Olson. Fifteen years ago, Olson bid farewell to the science world and shipped off to Hollywood ready to change the world. With films like Flock of Dodos: The Evolution-Intelligent Design Circus (Tribeca '06, Showtime) and Sizzle: A Global Warming Comedy (Outfest '08), he has tried to bridge the cultural divide that has too often left science on the outside looking in.Now, in his first book, Olson, with a Harvard Ph.D. and formerly a tenured professor of marine biology at the University of New Hampshire, recounts the lessons from his own hilarious-and at times humiliating-evolution from science professor to Hollywood filmmaker. In Don't Be Such a Scientist, he shares the secrets of talking substance in an age of style. The key, he argues, is to stay true to the facts while tapping into something more primordial, more irrational, and ultimately more human.In a book enlivened by a profane acting teacher who made Olson realize that "nobody wants to watch you think," he offers up serious insights and poignant stories. You'll laugh, you may cry, and as a communicator you'll certainly learn the importance of not only knowing how to fulfill, but also how to arouse.
Don't Be Such a Scientist, Second Edition: Talking Substance in an Age of Style
by Dr Randy OlsonWhen Randy Olson first described his life-changing encounter with an acting teacher in Don't Be Such a Scientist, it seemed like the world of science was on the cusp of gaining new respect in the public eye. Through his writing, speaking, and films, Olson challenged scientists to toss out jargon in favor of a more human approach, bringing Hollywood lessons to the scientific community. Yet today, in everything from government funding cuts to climate change denial, science is under attack. And while communicating science is more crucial than ever, the scientific community still struggles to connect with everyday people.The time is right for a new edition of Olson's revolutionary work. In Don't Be Such a Scientist, Second Edition, Olson renews his call for communication that stays true to the facts while tapping into something more primordial, more irrational, and ultimately more human. In more than 50 pages of new material, Olson brings his pioneering message to this new age, providing tools for speaking out in anti-science era and squaring off against members of the scientific establishment who resist needed change.Don't Be Such a Scientist, Second Edition is a cutting and irreverent manual to making your voice heard in an age of attacks on science. Invaluable for anyone looking to break out of the boxes of academia or research, Olson's writing will inspire readers to "make science human”—and to enjoy the ride along the way.
Don't Eat the Cleaners!: Tiny Fish with a Big Job
by null Susan StockdaleEven though they live underwater, ocean animals have to get clean, just like we do. But they get it done in a weird and wonderful way.Just like you have to take a bath and brush your teeth, fish also have basic hygiene practices they have to follow every day. But their approach to cleanliness doesn't just take place underwater—it involves a network of larger ocean animals washed by small fish and shrimp called cleaners at coral reef cleaning stations around the world.Cleaners remove pesky parasites from their customers in return for a tasty meal, serving up to 2000 customers a day. Sea turtles, manta rays, and even sharks line up for a scrubbing in the busy stations, just like at a car wash. Some customers return 100 times daily. And they must remember the important rule if they want a washing by the cleaning crew: DON&’T EAT THE CLEANERS!Readers will delight in this colorful exploration of the remarkable teamwork among coral reef residents. Back matter features images of all 30 animals and a fun matching game: can you find the animals in the book?In her latest nonfiction work, award-winning author-illustrator Susan Stockdale once again proves her talent in creating engaging and entertaining nature books for young readers.
Don't Know Much About the Universe
by Kenneth C. DavisWho dug those canals on Mars? What was the biblical Star of Bethlehem? Were the pyramids built by extraterrestrials?From the ancients who charted the heavens to Star Trek, The X-Files, and Apollo 13, outer space has intrigued people through the ages. Yet most of us look up at the night sky and feel totally in the dark when it comes to the basic facts about the universe.Kenneth C. Davis steps into that void with a lively and readable guide to the discoveries, theories, and real people who have shed light on the mysteries and wonders of the cosmos. Discover why Einstein was such a genius, the truth behind a blue moon or two, the amazing secrets of Stonehenge, and even how one great astronomer lost his nose.With the fun question-and-answer format that has appealed to the millions of readers of his bestselling Don't Much About® series, you'll be taking off on an exciting armchair exploration of the solar system, the Milky Way, and beyond.
Don't Look, Don't Touch, Don't Eat: The Science Behind Revulsion
by Valerie CurtisA scientist delves into what disgusts us and why: “For a book riddled with rancid and revolting things, [it] is surprisingly difficult to put down.” —Times Literary SupplementEvery flu season, sneezing, coughing, and graphic throat-clearing become background noise in workplaces. And coworkers tend to move as far—and as quickly—away from the source of these bodily eruptions as possible. Instinctively, humans recoil from objects that they view as dirty and even struggle to overcome feelings of discomfort once the offending item has been cleaned. These reactions are universal, and although there are cultural and individual variations, by and large we are all disgusted by the same things.In this book, Valerie Curtis builds a strong case for disgust as a “shadow emotion”—less familiar than love or sadness, it nevertheless affects our day-to-day lives. In disgust, biological and sociocultural factors meet in dynamic ways to shape human and animal behavior. Curtis traces the evolutionary role of disgust in disease prevention and hygiene, but also shows that it is much more than a biological mechanism. Human social norms, from good manners to moral behavior, are deeply rooted in our sense of disgust. The disgust reaction informs both our political opinions and our darkest tendencies, such as misogyny and racism. Through a deeper understanding of disgust, Curtis argues, we can take this ubiquitous human emotion and direct it towards useful ends, from combating prejudice to reducing disease.“Curtis, one of the deepest thinkers and cleverest researchers on this part of human nature, turns revulsion into fascination.” —Steven Pinker“Great fun.” —Toronto Star
Don't Teach Coding: Until You Read This Book
by Lindsey D. Handley Stephen R. FosterThe definitive resource for understanding what coding is, designed for educators and parents Even though the vast majority of teachers, parents, and students understand the importance of computer science in the 21st century, many struggle to find appropriate educational resources. Don't Teach Coding: Until You Read This Book fills a gap in current knowledge by explaining exactly what coding is and addressing why and how to teach the subject. Providing a historically grounded, philosophically sensitive description of computer coding, this book helps readers understand the best practices for teaching computer science to their students and their children. The authors, experts in teaching computer sciences to students of all ages, offer practical insights on whether coding is a field for everyone, as opposed to a field reserved for specialists. This innovative book provides an overview of recent scientific research on how the brain learns coding, and features practical exercises that strengthen coding skills. Clear, straightforward chapters discuss a broad range of questions using principles of computer science, such as why we should teach students to code and is coding a science, engineering, technology, mathematics, or language? Helping readers understand the principles and issues of coding education, this book: Helps those with no previous background in computer science education understand the questions and debates within the field Explores the history of computer science education and its influence on the present Views teaching practices through a computational lens Addresses why many schools fail to teach computer science adequately Explains contemporary issues in computer science such as the language wars and trends that equate coding with essential life skills like reading and writing Don't Teach Coding: Until You Read This Book is a valuable resource for K-12 educators in computer science education and parents wishing to understand the field to help chart their children’s education path.
Don't Tell the Boss!: How Poor Communication on Risks within Organizations Causes Major Catastrophes
by Dmitry Chernov Didier Sornette Giovanni Sansavini Ali AyoubThe book reviews existing research on the challenges of voice and silence in organizations. After a major disaster, when investigators are piecing together the story of what happened, a striking fact often emerges: before disaster struck, some people in the organization involved were aware of dangerous conditions that had the potential to escalate to a critical level. But for a variety of reasons, this crucial information did not reach decision-makers. So, the organization moved ever closer to catastrophe, effectively unaware of the possible threat—despite the fact that some of its employees could see it coming.What is the problem with communication about risk in an organization, and why does this problem exist? What stops people in organizations or project teams from freely reporting and discussing critical risks? This book seeks to answer these questions, starting from a deep analysis of 20 disasters where the concealment of risks played a major part.These case studies are drawn from around the world and span a range of industries: civil nuclear power, coal, oil and gas production, hydropower energy, metals and mining, space exploration, transport, finance, retail manufacturing and even the response of governments to wars, famines and epidemics.Together, case studies give an insight into why people hesitate to report risks—and even when they do, why their superiors often prefer to ignore the news.This helps to explain more generally why people dread passing on bad news to others—and why in the workplace they prefer to keep quiet about unpleasant facts or potential risks when they are talking to superiors and colleagues.The discussion section of the book includes important examples of concealment within the Chinese state hierarchy as well as by leading epidemiologists and governments in the West during the novel coronavirus outbreak in Wuhan in 2019-2020. The full picture of the very early stage of the COVID-19 pandemic remains unclear, and further research is obviously needed to better understand what motivated some municipal, provincial and national officials in China as well as Western counterparts to obfuscate facts in their internal communications about many issues associated with the outbreak.
Don't Touch That!: The Book of Gross, Poisonous, and Downright Icky Plants and Critters
by Jeff DayOffering helpful, humor-laced advice on how to avoid getting stung, bit, poked, jabbed, or poisoned--and what to do if it happens--this guide explains everything from rashes to anaphylaxis, tetanus to spider bites, and cat-scratch fever to rabies, all in kid-friendly language. A strong foundation in biology grounds the discussion, which explains how certain plants and animals can be dangerous and reveals medical information on the physical reactions they can produce. The topical trivia and goofy puns make learning fun both in the classroom and at home.
Don't Unplug: How Technology Saved My Life and Can Save Yours Too
by Chris DancyChris Dancy, the world's most connected person, inspires readers with practical advice to live a happier and healthier life using technologyIn 2002, Chris Dancy was overweight, unemployed, and addicted to technology. He chain-smoked cigarettes, popped pills, and was angry and depressed. But when he discovered that his mother kept a record of almost every detail of his childhood, an idea began to form. Could knowing the status of every aspect of his body and how his lifestyle affected his health help him learn to take care of himself? By harnessing the story of his life, could he learn to harness his own bad habits? With a little tech know-how combined with a healthy dose of reality, every app, sensor, and data point in Dancy's life was turned upside down and examined. Now he's sharing what he knows. That knowledge includes the fact that changing the color of his credit card helps him to use it less often, and that nostalgia is a trigger for gratitude for him. A modern-day story of rebirth and redemption, Chris' wisdom and insight will show readers how to improve their lives by paying attention to the relationship between how we move, what we eat, who we spend time with, and how it all makes us feel. But Chris has done all the hard work: Don't Unplug shows us how we too can transform our lives.
Doom with a View: Historical and Cultural Contexts of the Rocky Flats Nuclear Weapons Plant
by Kristen IversenTucked up against the Rocky Mountains, just west of Denver, sits the remnants of one of the most notorious nuclear weapons sites in North America: Rocky Flats. With a history of environmental catastrophes, political neglect, and community-wide health crises, this site represents both one of the darkest and most controversial chapters in our nation's history, and also a conundrum on repurposing lands once considered lost. As the crush of encroaching residential areas close in on this site and the generation of Rocky Flats workers passes on, the memory of Rocky Flats is receding from the public mind; yet the need to responsibly manage the site, and understand the consequences of forty years of plutonium production and contamination, must be a part of every decision for the land's future.
The Doomsday Calculation: How an Equation that Predicts the Future Is Transforming Everything We Know About Life and the Universe
by William PoundstoneFrom the author of Are You Smart Enough to Work at Google?, a fascinating look at how an equation that foretells the future is transforming everything we know about life, business, and the universe.In the 18th century, the British minister and mathematician Thomas Bayes devised a theorem that allowed him to assign probabilities to events that had never happened before. It languished in obscurity for centuries until computers came along and made it easy to crunch the numbers. Now, as the foundation of big data, Bayes' formula has become a linchpin of the digital economy.But here's where things get really interesting: Bayes' theorem can also be used to lay odds on the existence of extraterrestrial intelligence; on whether we live in a Matrix-like counterfeit of reality; on the "many worlds" interpretation of quantum theory being correct; and on the biggest question of all: how long will humanity survive?The Doomsday Calculation tells how Silicon Valley's profitable formula became a controversial pivot of contemporary thought. Drawing on interviews with thought leaders around the globe, it's the story of a group of intellectual mavericks who are challenging what we thought we knew about our place in the universe. The Doomsday Calculation is compelling reading for anyone interested in our culture and its future.
The Doomsday Handbook
by Alok JhaWe live in a world positively teeming with threats and apocalyptic scenarios. Many of them are familiar: terrorism, deadly viruses, global warming and war, but many others most of us can't even imagine: self-replicating nanobots that can devour an entire planet, high-energy experiments that threaten to suck the Earth into a mini black hole, and even super-sophisticated scientific contraptions that can put an end to the entire universe.
The Doomsday Lobby
by James T. BennettFederal patronage of science was never contemplated by the framers of the Constitution, but they did seek to "promote the Progress of Science and useful Art" by granting inventors patent rights. However, direct subvention to scientists and scientific organizations was not considered appropriate activity of the central government. In the 19th Century, American science was funded almost entirely through private investors. Since WWII, however, the federal government has become the primary patron of American science. From the race-to-space in the 1950s to current furor over global warming, Bennett traces the subtle and not-so-subtle ways in which government has co-opted scientific research and reinforced a culture in which challengers to proscribed wisdom are frozen out. Citing original documents and media reports, Bennett offers a compelling, entertaining, and thought-provoking perspective on political influence on scientific research and its implications for a democratic society. "During the Nineteenth Century, almost entirely on private funding, American science grew from practically nothing to world class. Now, however, over fifty percent of American science is funded by the federal government. Dr. Bennett traces the path, "crisis" after "crisis," by which American science became practically an arm of the federal government. His tale is a cautionary one, warning against future "crisis mongers" who would extend the government's already majority control of American science even further. His warning is a timely one, and it should be heeded." Joseph P. Martino, author of Science Funding: Politics and Porkbarrel "Bennett's latest book offers a challenging interpretation of the rise of the American federal science establishment since World War II. Focusing primarily on the growth of the space program, Bennett argues that crisis, real or imagined, is the source of state power and state funding for science. The Doomsday Lobby offers what no doubt will be viewed as a controversial contribution to the history of American science policy, and more broadly to an understanding of the role of the state in society." James D. Savage, Professor of Politics, University of Virginia, and author of Funding Science in America
The Doomsday Machine: The High Price of Nuclear Energy, the World's Most Dangerous Fuel
by Martin Cohen Andrew McKillopToday, there are over one hundred nuclear reactors operating in our backyards, from Indian Point in New York to Diablo Canyon in California. Proponents claim that nuclear power is the only viable alternative to fossil fuels, and due to rising energy consumption and the looming threat of global warming, they are pushing for an even greater investment. Here, energy economist Andrew McKillop and social scientist Martin Cohen argue that the nuclear power dream being sold to us is pure fantasy. Debunking the multilayered myth that nuclear energy is cheap, clean, and safe, they demonstrate how landscapes are ravaged in search of the elusive yellowcake to fuel the reactors, and how energy companies and politicians rarely discuss the true costs of nuclear power plants - from the subsidies that build the infrastructure to the unspoken guarantee that the public will pick up the cleanup cost in the event of a meltdown, which can easily top $100 billion dollars.
The Doomsday Vault (Everwhen School of Time Travel (and Other Odd Sciences))
by Thomas WheelerFrom the screenwriter of Academy Award–nominated Puss in Boots and Puss in Boots: The Last Wish comes an inventive middle grade adventure about an interdimensional school for time travelers perfect for fans of the Spy School and Mr. Lemoncello&’s Library series.When Bertie Wells accidentally creates a black hole in his bedroom in the year 1878, the last thing he expects is for a grown-up to step out. Darla Marconi comes with an offer: Bertie is invited to attend the EverWhen School of Time Travel and Other Odd Sciences. Not exactly thrilled at the idea, but not exactly having anything better to do, Bertie agrees. And that was only the first weird thing to happen to him that day. Thankfully, he's not alone—144 years in the future, math whiz Zoe Fuentes just accepted the same invitation, and 550 years in the past, Amelia da Vinci (yes, that da Vinci) has also decided to attend. Transported to 2024 for their first semester of school, these three must team up and work together in order to survive the year, including weathering a time paradox, solving the case of a disappearing dean, and uncovering the truth behind a shady intergalactic secret society. At least time is on their side!
Dopamine: Endocrine and Oncogenic Functions
by Nira Ben-JonathanDopamine is a small molecule traditionally regarded as a brain-derived neuronal modulator implicated in many neurological and psychiatric disorders. Outside the brain, dopamine fulfills all the criteria of a circulating hormone which affects normal and abnormal functions of multiple organs and regulatory systems and is also involved in many aspects of cancer formation and progression. This book provides a much needed systematic account of dopamine as an endocrine and autocrine/paracrine hormone and fills a major gap in the overall understanding of the production, distribution and actions of this very important molecule. Key Features: Explores the many different faces of dopamine as autocrine, paracrine and endocrine molecule Documents the adverse effects of antipsychotics on dopamine functions Reviews the many ways dopamine affects the cardiovascular, renal and reproductive systems Provides updates on receptor oligomerization and signaling Examines the role of dopamine in tumorigenesis Related Titles Jones, S. ed. Dopamine - Glutamate Interactions in the Basal Ganglia (ISBN 978-0-3673-8197-4) Luo, L. Principles of Neurobiology (ISBN 978-0-8153-4494-0) Sidhu, A. et al., eds. Dopamine Receptors and Transporters (ISBN 978-0-8247-0854-2)
Dopamine
by Nadine KabbaniDopamine, a catecholamine transmitter, plays a number of vital physiological roles in the brain and body, and, in recent years, studies on the role of dopamine in disease have opened new avenues of research and discovery. In Dopamine: Methods and Protocols, experts and key figures within the field provide detailed protocols on leading approaches in the study of dopamine within biological systems. Divided into sections on cellular/biochemical, imaging, genetics, and electrophysiology, this collections includes protocols for bioluminescence and fluorescence imaging, receptor immunoprecipitation and proteomic analysis, creation and characterization of a mouse model of Parkinson's disease, real time measurement of dopamine in the brain, and modeling signal transduction in silico. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective subjects, lists of materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and convenient, Dopamine: Methods and Protocols serves as an ideal guide for students and experts alike, as well as for anyone interested in exploring the vast and crucial field of dopamine research.