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Drug-Drug Interactions: Progress And Future Challenges (Drugs And The Pharmaceutical Sciences Ser.)
by A. David RodriguesAuthored by renowned leaders in the field, this comprehensive volume covers all aspects of drug-drug interactions, including preclinical, clinical, toxicological, and regulatory perspectives.Thoroughly updated, this second edition reflects the significant advances and includes extensive new material on:key interplay between transporters and enzymes
Drug-induced and Iatrogenic Respiratory Disease
by Phillipe Camus Edward Rosenow IIIAt the present time, 430 drugs are known to cause respiratory injury. This represents an increase of almost 200 in the last ten years, and the number is still increasing. This comprehensive, definitive reference work, with an outstanding range of international expert contributors and two of the world's leading editors, provides an essential referen
Druggable Lipid Signaling Pathways (Advances in Experimental Medicine and Biology #1274)
by Yasuyuki KiharaLipids are responsible not just for constituting cellular membrane but also for storing energy, transducing signaling, and modifying proteins. Bioactive lipids, or lipid mediators, transduce signaling as intracellular messenger like phosphoinoitides, and also regulate cell-cell communication through G protein-coupled receptors (GPCRs) that are potentially valuable drug targets in many diseases. Until now, about 40 GPCRs within ~300 rhodopsin-like (class A) GPCRs, are identified as lipid GPCRs. Advances of lipid research have enabled to develop novel small molecules targeting lipid GPCRs for several diseases. Most notably, fingolimod (FTY720), a sphingosine 1-phosphate (S1P) receptor modulator, became the first FDA-approved medicine as an orally bioavailable drug for treating relapsing forms of multiple sclerosis (MS). In addition to fingolimod, other drugs targeting lipid GPCRs had been developed such as latanoprost (prostaglandin F2a analogue, used for ocular hypertension and glaucoma), epoprostenol and treprostinil (prostaglandin I2 analogue, used for pulmonary arterial hypertension), montelukast and pranlukast (cysteinyl leukotriene receptor antagonist, used for asthma and allergies), etc. Novel drugs are also expected like lysophosphatidic acid (LPA) receptor antagonist for treatment of pulmonary fibrosis. Drug development targeting lipid signalling pathways are backdated to more than a century, when aspirin was synthesized and selling by Bayer, while the basic mechanism of aspirin's effects (block prostanoid synthesis by inhibiting cyclooxygenases) had not been discovered until 1970s. Nowadays, non-steroidal anti-inflammatory drugs (NSAIDs) like aspirin and ibuprophen are commonly used as antipyretic analgesics and available readily over-the-counter oral drugs. Both upstream and downstream enzymes, such as phospholipase A2s and prostaglandin E synthases, respectively, are also potential therapeutic targets for inflammatory diseases. Recent studies of lipid metabolism expand the lipid biology field from pro-inflammatory lipid mediators to anti-inflammatory epoxy fatty acids (epoxyeicosatrienoic acids), and also omega-3 fatty acid-derived pro-resolving lipid mediators (lipoxin, resolvin, and neuroprotectin). These bioactive lipids, their metabolic pathways and receptors are of great interest in developing next-generation anti-inflammatory and pro-resolving drugs for a wide variety of diseases including. This book summarizes not only historical overview of lipid signaling pathways but also provides summary of cutting-edge studies that may provide some hints of novel “druggable” lipid signaling targets.
Drugs
by Rick Ng"Concise and easy to read, the book quickly introduces basic concepts, then moves on to discuss target selection and the drug discovery process for both small and large molecular drugs."--Doody's Reviews, May 2009"The second edition of a book that offers a user-friendly step-by-step introduction to all the key processes involved in bringing a drug to the market, including the performance of preclinical trials."--Chemistry World, February 2009The new edition of this best-selling book continues to offer a user-friendly, step-by-step introduction to all the key processes involved in bringing a drug to the market, including the performance of pre-clinical studies, the conduct of human clinical trials, regulatory controls, and even the manufacturing processes for pharmaceutical products. Concise and easy to read, the book quickly introduces basic concepts, then moves on to discuss target selection and the drug discovery process for both small and large molecular drugs.This second edition features many key enhancements, including Key Points, Chapter Summary, and Review Questions in each chapter, Answers to Review Questions provided in a book-end appendix, and one or two carefully selected "mini" case studies in each chapter.Richly illustrated throughout with over ninety figures and tables, this important book also includes helpful listings of current FDA and European guidelines and a special section on regulatory authority and processes in China. It is an indispensable resource for pharmaceutical industry and academic researchers, pharmaceutical managers and executives, healthcare clinicians, policymakers, regulators, and lobbyists with an interest in drug development. It is also an excellent textbook for students in pharmacy, science, and medicine courses.
Drugs That Changed the World: How Therapeutic Agents Shaped Our Lives
by Irwin W. ShermanDrugs are used in the diagnosis, alleviation, treatment, prevention or cure of disease. This is a book about drugs, how they came to be, and how they exert their ‘magic’. Today we have drugs to protect against infectious diseases, to alleviate aches and pains, to allow new organs to replace the old, and for brain functions to be modified. Yet, for the most part the manner by which drugs are developed and by whom remains a mystery. Drugs are more than just a pill or liquid and some have markedly altered history. The author has selected a few drugs – highlights representing milestones affecting our well-being and influencers of social change. The stories told are dramatic and include spectacular successes and dismal failures. And the people about whom these stories are told are both saints and sinners – selfless and conniving – bold and mercurial and shy and retiring loner. The drugs themselves mirror the diversity of their origin stories and the author assembles all sides of these fascinating stories.
Drugs and Society
by Glen R. Hanson Annette E. Fleckenstein Peter J. VenturelliThoroughly revised and updated, Drugs and Society, Eleventh Edition, contains the most current information available concerning drug use and abuse. Written in an objective and user-friendly manner, this best-selling text continues to captivate students by taking a multidisciplinary approach to the impact of drug use and abuse on the lives of ordinary people. The Eleventh Edition incorporates the authors#146; combined expertise in pharmacology, drug abuse, and sociology and extensive experience in research, teaching, drug policy-making, and drug policy implementation and includes hundreds of new citations that reflect the current state of drug abuse issues and the rapidly changing issues of substance abuse/addiction.
Drugs and a Methodological Compendium: From bench to bedside
by Vikrant Singh Rajput Ashish RunthalaThis book provides a meticulous view on methodological drug discovery and development insights from bench to bedside. The current book threads almost each step encompassing drug the discovery and development of a molecule. The chapters focus on computational modus operandi, pharmacological optimization approaches, modern high-throughput screening methods and in-vitro procedures, role of structural biologists in drug discovery and development, medicinal chemistry approaches for drug design, formulation and drug delivery, in-vivo evaluations of candidate molecules, clinical trial procedures and others. The book also covers specific case studies, regulatory approval proceedings, and industrial view point alongside the aforementioned conceptual layout. And at the same time, the volume integrates medical, biological, medicinal, pharmacological and computational streams, and it is suggested as an ideal guideline to a wide audience including molecular biologists, biochemist, pharmacologists, medicinal chemist, toxicologists, drug discovery and development researchers, and all other students interested in these disciplines.
Drugs and the Neuroscience of Behavior: An Introduction to Psychopharmacology
by Adam PrusDrugs and the Neuroscience of Behavior: An Introduction to Psychopharmacology, Second Edition by Adam Prus presents an introduction to the rapidly advancing field of psychopharmacology by examining how drug actions in the brain affect psychological processes. The book provides historical background to give readers an appreciation for the development of drug treatments and neuroscience over time, covering major topics in psychopharmacology, including new drugs and recent trends in drug use. Pedagogical features informed by the latest scholarship in teaching and learning are integrated throughout the text to ensure that readers are able to process and understand the material with ease.
Drugs and the Neuroscience of Behavior: An Introduction to Psychopharmacology
by Adam PrusDrugs and the Neuroscience of Behavior: An Introduction to Psychopharmacology, Second Edition by Adam Prus presents an introduction to the rapidly advancing field of psychopharmacology by examining how drug actions in the brain affect psychological processes. The book provides historical background to give readers an appreciation for the development of drug treatments and neuroscience over time, covering major topics in psychopharmacology, including new drugs and recent trends in drug use. Pedagogical features informed by the latest scholarship in teaching and learning are integrated throughout the text to ensure that readers are able to process and understand the material with ease.
Drugs and the Neuroscience of Behavior: An Introduction to Psychopharmacology
by Adam PrusDrugs and the Neuroscience of Behavior presents an introduction to the rapidly advancing field of psychopharmacology by examining how drug actions in the brain affect psychological processes. Author Adam Prus provides historical background to give readers an appreciation for the development of drug treatments and neuroscience over time, covering major topics in psychopharmacology including new drugs and recent trends in drug use. Empirically supported pedagogical features offer students the opportunity to reflect on what they read to ensure understanding before progressing to new content. The Third Edition includes a new chapter on depressants and discussions of major topics such as the opioid epidemic, the risks associated with vaping, and MDMA-assisted psychotherapy for PTSD. Included with this title: The password-protected Instructor Resource Site (formally known as SAGE Edge) offers access to all text-specific resources, including a test bank and editable, chapter-specific PowerPoint® slides.
Drugs and the Neuroscience of Behavior: An Introduction to Psychopharmacology
by Adam PrusDrugs and the Neuroscience of Behavior presents an introduction to the rapidly advancing field of psychopharmacology by examining how drug actions in the brain affect psychological processes. Author Adam Prus provides historical background to give readers an appreciation for the development of drug treatments and neuroscience over time, covering major topics in psychopharmacology including new drugs and recent trends in drug use. Empirically supported pedagogical features offer students the opportunity to reflect on what they read to ensure understanding before progressing to new content. The Third Edition includes a new chapter on depressants and discussions of major topics such as the opioid epidemic, the risks associated with vaping, and MDMA-assisted psychotherapy for PTSD. Included with this title: The password-protected Instructor Resource Site (formally known as SAGE Edge) offers access to all text-specific resources, including a test bank and editable, chapter-specific PowerPoint® slides.
Drugs from Nature: Targets, Assay Systems and Leads
by Sabu Abdulhameed Madhathilkovilakathu Haridas Dileep Francis Swaroop S KumarThis book provides an overview of the drug discovery process from natural sources such as plants and microbes. While technological advances have streamlined the drug discovery process, enhancing the throughput and success rates, the structural features of natural products remain the primary reference for small-molecule drug discovery. Focusing on the drug targets blocked/altered by natural/nature-inspired molecules, it covers how potential drug leads are screened and identified using appropriate assay systems, and the current status of drugs identified using such approaches. State-of-the-art approaches in target identification, assay development, and lead identification have also been discussed in detail. Other topics included are targets and leads in inflammation, cancer, reproductive medicine, cardiovascular and neuromuscular ailments, and infectious diseases as well as the challenges in translating drug leads into clinically viable drugs. This volume serves as a handbook for researchers in phytochemistry and drug discovery, and as a reference for researchers and students of applied biology.
Drugs of Abuse and Addiction: Neurobehavioral Toxicology
by R J.M. Niesink R.M.A. Jaspers,Drugs of Abuse and Addiction: Neurobehavioral Toxicology examines drugs of abuse and addiction and how they affect behavior. This book considers the entire range of addiction research in humans and animals, using a multidisciplinary approach to discuss all areas of the neuro- and behavioral sciences involved. Emphasis is on acute and chronic effect
Drugs, Enzymes and Receptors of the Renin-Angiotensin System: Celebrating a Century of Discovery
by Ahsan Husain Robert M. GrahamSince 1898, when Tigerstadt and Bergman first extracted renin from rabbit kidney, the reninrugs, Enzymes and Receptors of the Renin is designed to highlight molecular and clinical approaches to understanding the reninChapter topics have been specifically chosen to cover selected contemporary, controversial and unresolved issues. A novel and uni
Drugs, the Brain, and Behavior: The Pharmacology of Drug Use Disorders
by Carlton K. Erickson John BrickExplore the brain and discover the clinical and pharmacological issues surrounding drug abuse and dependence. The authors, research scientists with years of experience in alcohol and drug studies, provide definitions, historic discoveries about the nervous system, and original, eye-catching illustrations to discuss the brain/behavior relationship, basic neuroanatomy, neurophysiology, and the mechanistic actions of mood-altering drugs. You will learn about:• how psychoactive drugs affect cognition, behavior, and emotion• the brain/behavior relationship • the specific effects of major addictive and psychoactive drug groups • new definitions and thinking about abuse and dependence• the medical and forensic consequences of drugs use Drugs, the Brain, and Behavior uses a balance of instruction, illustrations, and tables and formulas that will give you a broad, lasting introduction to this intriguing subject. Whether you're a nurse, chemical dependency counselor, psychologist, or clinician, this book will be a quick reference guide long after the first reading.
Drugs, the Brain, and Behavior: The Pharmacology of Therapeutics and Drug Use Disorders
by John BrickThis third edition of Drugs, the Brain, and Behavior provides a comprehensive overview of the brain and explores the clinical and pharmacological issues surrounding drug abuse and dependence.Dr Brick provides definitions, historic discoveries about the nervous system, and original, eye-catching illustrations to discuss the brain/behavior relationship, basic neuroanatomy, neurophysiology, and the mechanistic actions of mood-altering drugs. Topics include: how psychoactive drugs affect cognition, behavior, and emotion; the brain/behavior relationship; the specific effects of major addictive and psychoactive drug groups; new definitions and thinking about abuse and dependence; and the medical uses of drugs, such as cannabinoids. A new chapter on biobehavioral markers explores how markers can guide the clinician in the diagnosis of some disorders. This book offers a quick reference guide which uses a balance of instruction, illustrations, tables, and formulas, that will give you a broad, lasting introduction to this intriguing subject.Drugs, the Brain, and Behavior is an invaluable resource for students in the field, nurses, psychologists, counsellors, physicians and other health care professionals.
Drunk Flies and Stoned Dolphins: A Trip Through the World of Animal Intoxication
by One R. PaganFrom the cup of coffee that jumpstarts the day to dangerously addictive drugs, the recreational use of plants with psychoactive properties has a long history among humans. But, as with many things, it turns out that other animals got there first. From parrots to primates, consuming medicinal chemicals is an instinctive behavior that helps countless organisms fight infection and treat disease. But the similarities don't end there: Like us, many creatures also consume substances that have no apparent benefit . . . except for inducing intoxication. In fact, animals have been using drugs for recreational purposes since prehistoric times. We may even have animals to thank for the idea—legend says that coffee was discovered by observing the behavior of goats that had eaten it. In his previous book, Strange Survivors, author and biologist Oné R. Pagán introduced readers to some of the truly bizarre strategies animals use to survive in the cutthroat world of natural selection. Now, in Drunk Flies and Stoned Dolphins, he sheds light on the surprising cravings they indulge when it's time to unwind. In this book, you'll get an eye-opening glimpse into the mind-altering behavior of the non-human members of the animal kingdom, spanning insects to elephants—including the dolphin species that apparently likes to pass around an intoxicating pufferfish as if they were sharing a joint. Combining fascinating science with humor and enthusiasm, Pagán's latest is full of the kind of unforgettable stories and odd facts that you'll find yourself repeating to everyone you meet. From fruit fly happy hour to the evolutionary reasons behind nature's drugs, Drunk Flies and Stoned Dolphins takes you on a trip through the colorful world of animal intoxication—and along the way, explores what this science reveals about the surprising connections between all the world's creatures.
Drunk: How We Sipped, Danced, and Stumbled Our Way to Civilization
by Edward SlingerlandA "entertaining and enlightening" deep dive into the alcohol-soaked origins of civilization—and the evolutionary roots of humanity&’s appetite for intoxication. (Daniel E. Lieberman, author of Exercised) While plenty of entertaining books have been written about the history of alcohol and other intoxicants, none have offered a comprehensive, convincing answer to the basic question of why humans want to get high in the first place. Drunk elegantly cuts through the tangle of urban legends and anecdotal impressions that surround our notions of intoxication to provide the first rigorous, scientifically-grounded explanation for our love of alcohol. Drawing on evidence from archaeology, history, cognitive neuroscience, psychopharmacology, social psychology, literature, and genetics, Slingerland shows that our taste for chemical intoxicants is not an evolutionary mistake, as we are so often told. In fact, intoxication helps solve a number of distinctively human challenges: enhancing creativity, alleviating stress, building trust, and pulling off the miracle of getting fiercely tribal primates to cooperate with strangers. Our desire to get drunk, along with the individual and social benefits provided by drunkenness, played a crucial role in sparking the rise of the first large-scale societies. We would not have civilization without intoxication. From marauding Vikings and bacchanalian orgies to sex-starved fruit flies, blind cave fish, and problem-solving crows, Drunk is packed with fascinating case studies and engaging science, as well as practical takeaways for individuals and communities. The result is a captivating and long overdue investigation into humanity's oldest indulgence—one that explains not only why we want to get drunk, but also how it might actually be good for us to tie one on now and then.
Dry Fish: A Global Perspective on Nutritional Security and Economic Sustainability
by Amit Ranjan S. A. ShanmugamDry fish is an excellent and cheap source of protein and fat in both developed and developing nations, especially for vulnerable populations. Its nutritional value, cultural importance, and economic relevance make it an integral part of diets and food systems worldwide. The diverse culinary applications and international trade of dry fish further highlight its relevance and appeal on a global scale. It offers distinct taste and flavors, adding diversity to global cuisines and enhancing culinary experiences. It is used in various recipes, from stews and curries to snacks and condiments and is highly valued for its long shelf life and nutritional benefits. Consumption of dry fish not only improves nutrition but also has far-reaching impacts on the economy, society and cultural practices. It meets the dietary requirements of marginalized communities and contributes to food security. In coastal regions, salted and sun-dried fish are widely consumed, reflecting the importance of this preservation method. Dry fish plays a crucial role in nutritional security, particularly in coastal areas, where it holds immense importance for the economy, society, and culture. Dry fish also serves as a valuable commodity in international markets, fostering cross-cultural exchanges and contributing to trade flows. Furthermore, dry fish has gained popularity in various global cuisines. Countries like Portugal, Spain, Thailand and several African nations have their own versions of dried or salted fish dishes, reflecting the diverse culinary traditions and preferences around the world. Dry Fish: A Global Perspective on Nutritional Security and Economic Sustainability offers a global perspective on the sustainability of dry fish production and its environmental implications. It explores traditional and advanced drying methods, their impact on fish stocks and potential strategies for sustainable practices. The text discusses the challenges and opportunitiesin the industry, such as market trends, consumer preferences and technological advancements. The book combines scientific research, case studies and expert insights to provide a comprehensive overview of the topic. It serves as a valuable resource for researchers, policymakers and professionals in the fields of nutrition, food security, fisheries and economic development. By highlighting the importance of dry fish as a global resource, the book aims to foster discussions and actions that promote the sustainable utilization of this valuable food source for the benefit of present and future generations.
Dry Gross Fretting of Rough Surfaces: Influential Parameters (SpringerBriefs in Applied Sciences and Technology)
by Pawel Pawlus Andrzej Dzierwa Agnieszka LenartIn this book, the authors present a comprehensive study of the effects of operating parameters (load, amplitude, frequency) on dry gross fretting of rough surfaces. It helps the reader to efficient surface preparations in order to monitor and reduce damage caused by fretting. It exposes the effect of surface topography on fretting, which is often neglected.
Dry Mineral Processing
by Saeed Chehreh Chelgani Ali Asimi NeisianiThis book introduces and explains all existing dry processing methods, drawing from larges studies about these techniques in both the academia and industrial sectors. Potentially, water insufficiency is one of the critical issues that could be the major cause of international conflicts. Thus, reducing water consumption and pollution in all industrial sectors is an essential issue for all countries. As a main part of the mining industry, ore processing plants are highly dependent on water, and water scarcity poses significant risk to the industry. Thus, water consumption is a strategic issue for mineral processing plants, particularly in dry climate countries. To select dry or wet processing, the differences between these conditions should be taken into consideration, which needs an in-depth understanding of the various possible methods. This book will be of interest to professionals and researchers.
Dry Storeroom No. 1
by Richard ForteyDry Store Room No. 1 is an intimate biography of the Natural History Museum, celebrating the eccentric personalities who have peopled it and capturing the wonders of scientific endeavour, academic rigour and imagination. This book is a kind of museum of the mind. It is my own collection, a personal archive, designed to explain what goes on behind the polished doors in the Natural History Museum. The lustre of a museum does not depend only on the artefacts or objects it contains the people who work out of sight are what keeps a museum alive. I want to bring those invisible people into the sunlight. Behind the public facade of any great museum there lies a secret domain: one of unseen galleries, locked doors, priceless specimens and hidden lives. Through the stories of the numerous eccentric individuals whose long careers have left their mark on the study of evolutionary science, Richard Fortey, former senior paleontologist at London's Natural History Museum, celebrates the pioneering work of the Museum from its inception to the present day. He delves into the feuds, affairs, scandals and skulduggery that have punctuated its long history, and formed a backdrop to extraordinary scientific endeavour. He explores the staying power and adaptability of the Museum as it responds to changes wrought by advances in technology and molecular biology -- 'spare' bones from an extinct giant bird suddenly become cutting-edge science with the new knowledge that DNA can be extracted from them, and ancient fish are tested with the latest equipment that is able to measure rises in pollution. Dry Store Room No. 1 is a fascinating and affectionate account of a hidden world of untold treasures, where every fragment tells a story about time past, by a scientist who combines rigorous professional learning with a gift for prose that sparkles with wit and literary sensibility.
Dry Urbanism: Designing for Drought in the City (Contemporary Urban Design Thinking)
by Rob RoggemaThe ambition of the book is to give a contemporary insight in the state of the art when it comes to designing our cities and landscapes for dry conditions. Water, or the absence thereof, is an important issue to consider. Many cities around the world are increasingly suffering heat, droughts and occasional severe flooding and rainfall. This asks for new approaches, and methodologies to (re)design the urban and rural condition to stay livable. This book aims to connect theories (the methodologies and approaches) with practice (concrete examples and projects).
Drying Phenomena
by Calin Zamfirescu Ibrahim DincerPresents a comprehensive framework of drying phenomena and applications along with state-of-the-art research, fundamentals, research methodologies, novel systems and future prospects. Virtual Experiments in Mechanical Vibrations: Structural Dynamics and Signal Processing brings together topics in mechanical vibration and signal processing under the umbrella of virtual experiments in vibration. To achieve the aim of the reader being able to conduct some virtual experiments on vibration isolators, vibration absorbers, and distributed parameter structures such as beams and rods, a thorough grounding is provided in the vibrations and signal processing in the early chapters. The emphasis will be on physics rather than mathematics throughout the book. The second part of the book will contain the virtual experiments. Virtual Experiments in Mechanical Vibrations: Structural Dynamics and Signal Processing is an ideal book for a student, researcher or engineer with limited knowledge of vibrations and signal processing who has to carry out some experimental work in vibrations. Reveals research-oriented scientific vision, industrial concepts and prospects and interdisciplinary coverage within drying technology Includes detailed thermodynamic and heat/mass transfer analyses in a reader-friendly and easy-to-follow approach, as well as experimental and computational approaches, applicable for both professional engineers and academics Employs a logical and didactic approach with easy to follow explanations, case studies, illustrative examples and chapter-end problems.
Drying and Roasting of Cocoa and Coffee (Advances in Drying Science and Technology)
by Ching Lik Hii Flávio Meira BorémThis is the first practical book dedicated to the fundamental and application aspects of two major unit operations in cocoa and coffee processing, namely drying and roasting. The drying and roasting of cocoa and coffee beans play critical roles in governing the formation of flavor precursors in the early stages and also the development of flavor and aroma in the later stages during processing. Hence, qualities of the finished chocolates and coffee powder products are affected greatly by the dried and roasted beans produced. Drying and Roasting of Cocoa and Coffee covers key topics areas ranging from post-harvest processing, equipment selection, physical and chemical changes during processing, flavor development, grading and dried product quality. The book consists of two parts with topics dedicated to the drying/roasting aspects of cocoa and coffee, respectively. Features Provides a comprehensive review on flavor development during cocoa/coffee processing Discusses the impact of processing parameters on cocoa/coffee quality Presents the new trends in drying/roasting techniques and novel technology Examines the concept of coffee quality in light of both paradigms: the traditional coffee and the specialty coffee grading systems No prior knowledge of cocoa and coffee processing is required to benefit from this book, which is written for a variety of readers. It is suitable for undergraduate and postgraduate students, researchers and industrial practitioners/consultants from various domains in the food and beverage industries.