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The Age of Genomes: Tales from the Front Lines of Genetic Medicine
by Steven Monroe Lipkin Jon LuomaA leading geneticist explores what promises to be one of the most transformative advances in health and medicine in historyAlmost every week, another exciting headline appears about new advances in the field of genetics. Genetic testing is experiencing the kind of exponential growth once seen with the birth of the Internet, while the plummeting cost of DNA sequencing makes it increasingly accessible for individuals and families.Steven Lipkin and Jon Luoma posit that today's genomics is like the last century's nuclear physics: a powerful tool for good if used correctly, but potentially dangerous nonetheless. DNA testing is likely the most exciting advance in a long time for treating serious disease, but sequencing errors, complex biology, and problems properly interpreting genetic data can also cause life-threatening misdiagnoses of patients with debilitating and fatal genetic diseases. DNA testing can also lead to unnecessary procedures and significantly higher health-care costs. And just around the corner is the ability to cure genetic diseases using powerful gene-editing technologies that are already being used in human embryo research. Welcome to the Age of Genomes!The Age of Genomes immerses readers in true stories of patients on the frontier of genomic medicine and explores both the transformative potential and risks of genetic technology. It will inform anxious parents increasingly bombarded by offers of costly new prenatal testing products, and demonstrate how genetic technology, when deployed properly, can significantly improve the lives of patients who have devastating neurological diseases, cancer, and other maladies. Dr. Lipkin explains the science in depth, but in terms a layperson can follow.
The Age of Living Machines: How Biology Will Build The Next Technology Revolution
by Susan HockfieldFrom the former president of MIT, the story of the next technology revolution, and how it will change our lives. A century ago, discoveries in physics came together with engineering to produce an array of astonishing new technologies: radios, telephones, televisions, aircraft, radar, nuclear power, computers, the Internet, and a host of still-evolving digital tools. These technologies so radically reshaped our world that we can no longer conceive of life without them. Today, the world’s population is projected to rise to well over 9.5 billion by 2050, and we are currently faced with the consequences of producing the energy that fuels, heats, and cools us. With temperatures and sea levels rising, and large portions of the globe plagued with drought, famine, and drug-resistant diseases, we need new technologies to tackle these problems. But we are on the cusp of a new convergence, argues world-renowned neuroscientist Susan Hockfield, with discoveries in biology coming together with engineering to produce another array of almost inconceivable technologies—next-generation products that have the potential to be every bit as paradigm shifting as the twentieth century’s digital wonders. The Age of Living Machines describes some of the most exciting new developments and the scientists and engineers who helped create them. Virus-built batteries. Protein-based water filters. Cancer-detecting nanoparticles. Mind-reading bionic limbs. Computer-engineered crops. Together they highlight the promise of the technology revolution of the twenty-first century to overcome some of the greatest humanitarian, medical, and environmental challenges of our time.
The Age of Radiance: The Epic Rise and Dramatic Fall of the Atomic Era
by Craig Nelson“A thrilling, intense, and disturbing account of the atomic era, from the discovery of X-rays to the tragic meltdown of Japan’s Fukushima Daiichi nuclear power plant…Rich with powerful images and fraught with drama” (The Christian Science Monitor).When Marie Curie, Enrico Fermi, and Edward Teller forged the science of radioactivity, they began a revolution that ran from the nineteenth century through the course of World War II and the Cold War to our current confrontation with the dangers of nuclear power and proliferation. While nuclear science improves our lives, radiation’s invisible powers can trigger cancer and cellular mayhem. Writing with a biographer’s passion, New York Times bestselling author Craig Nelson unlocks one of the great mysteries of the universe. In The Age of Radiance, Nelson illuminates a pageant of fascinating historical figures: Albert Einstein, Niels Bohr, J. Robert Oppenheimer, Curtis LeMay, John F. Kennedy, Robert McNamara, Ronald Reagan, and Mikhail Gorbachev, among others. He reveals how Jewish scientists fleeing Hitler transformed America from a nation that created light bulbs into one that split atoms; Alfred Nobel’s dream of global peace; and how, in our time, emergency workers and utility employees fought to contain life-threatening nuclear reactors. By tracing our complicated relationship with the dangerous energy we unleashed, Nelson discusses how atomic power and radiation are indivisible from our everyday lives. Brilliantly told and masterfully crafted, The Age of Radiance provides a new understanding of a misunderstood epoch in history and restores to prominence the forgotten heroes and heroines who have changed all of our lives for better and for worse. “This is the kind of book that doesn’t just inform you but leaves you feeling smarter.” (The Dallas Morning News).
The Age of Scientific Wellness: Why the Future of Medicine Is Personalized, Predictive, Data-Rich, and in Your Hands
by Leroy Hood Nathan PriceTaking us to the cutting edge of the new frontier of medicine, a visionary biotechnologist and a pathbreaking researcher show how we can optimize our health in ways that were previously unimaginable.We are on the cusp of a major transformation in healthcare—yet few people know it. At top hospitals and a few innovative health-tech startups, scientists are working closely with patients to dramatically extend their “healthspan”—the number of healthy years before disease sets in. In The Age of Scientific Wellness, two visionary leaders of this revolution in health take us on a thrilling journey to this new frontier of medicine.Today, most doctors wait for clinical symptoms to appear before they act, and the ten most commonly prescribed medications confer little or no benefit to most people taking them. Leroy Hood and Nathan Price argue that we must move beyond this reactive, hit-or-miss approach to usher in real precision health—a form of highly personalized care they call “scientific wellness.” Using information gleaned from our blood and genes and tapping into the data revolution made possible by AI, doctors can catch the onset of disease years before symptoms arise, revolutionizing prevention. Current applications have shown startling results: diabetes reversed, cancers eliminated, Alzheimer’s avoided, autoimmune conditions kept at bay.This is not a future fantasy: it is already happening, but only for a few patients and at high cost. It’s time to make this gold standard of care more widely available. Inspiring in its possibilities, radical in its conclusions, The Age of Scientific Wellness shares actionable insights to help you chart a course to a longer, healthier, and more fulfilling life.
The Age of Spiritual Machines: When Computers Exceed Human Intelligence
by Ray KurzweilRay Kurzweil is the inventor of the most innovative and compelling technology of our era, an international authority on artificial intelligence, and one of our greatest living visionaries. Now he offers a framework for envisioning the twenty-first century--an age in which the marriage of human sensitivity and artificial intelligence fundamentally alters and improves the way we live. Kurzweil's prophetic blueprint for the future takes us through the advances that inexorably result in computers exceeding the memory capacity and computational ability of the human brain by the year 2020 (with human-level capabilities not far behind); in relationships with automated personalities who will be our teachers, companions, and lovers; and in information fed straight into our brains along direct neural pathways. Optimistic and challenging, thought-provoking and engaging, The Age of Spiritual Machines is the ultimate guide on our road into the next century.
The Age of Subtlety: Nature and Rhetorical Conceits in Early Modern Europe (The Early Modern Exchange)
by Javier Patiño LoiraA craze for intricate metaphors, referred to as conceits, permeated all forms of communication in seventeenth-century Italy and Spain, reshaping reality in highly creative ways. The Age of Subtlety: Nature and Rhetorical Conceits in Early Modern Europe situates itself at the crossroads of rhetoric, poetics, and the history of science, analyzing technical writings on conceits by such scholars as Baltasar Gracián, Matteo Peregrini, and Emanuele Tesauro against the background of debates on telescopic and microscopic vision, the generation of living beings, and the boundaries between the natural and the artificial. It contends that in order to understand conceits, we must locate them within the early modern culture of ingenuity that was also responsible for the engineer’s machines, the juggler’s sleight of hand, the wiles of the statesman, and the discovery of truths about nature.
The Age of Sustainability: Just Transitions in a Complex World (Routledge Studies in Sustainable Development)
by Mark SwillingWith transitions to more sustainable ways of living already underway, this book examines how we understand the underlying dynamics of the transitions that are unfolding. Without this understanding, we enter the future in a state of informed bewilderment. Every day we are bombarded by reports about ecosystem breakdown, social conflict, economic stagnation and a crisis of identity. There is mounting evidence that deeper transitions are underway that suggest we may be entering another period of great transformation equal in significance to the agricultural revolution some 13,000 years ago or the Industrial Revolution 250 years ago. This book helps readers make sense of our global crisis and the dynamics of transition that could result in a shift from the industrial epoch that we live in now to a more sustainable and equitable age. The global renewable energy transition that is already underway holds the key to the wider just transition. However, the evolutionary potential of the present also manifests in the mushrooming of ecocultures, new urban visions, sustainability-oriented developmental states and new ways of learning and researching. Shedding light on the highly complex challenge of a sustainable and just transition, this book is essential reading for anyone concerned with establishing a more sustainable and equitable world. Ultimately, this is a book about hope but without easy answers.
Age of System: Understanding the Development of Modern Social Science
by Hunter HeyckIn the years after World War II, a new generation of scholars redefined the central concepts and practices of social science in America.Before the Second World War, social scientists struggled to define and defend their disciplines. After the war, "high modern" social scientists harnessed new resources in a quest to create a unified understanding of human behavior—and to remake the world in the image of their new model man.In Age of System, Hunter Heyck explains why social scientists—shaped by encounters with the ongoing "organizational revolution" and its revolutionary technologies of communication and control—embraced a new and extremely influential perspective on science and nature, one that conceived of all things in terms of system, structure, function, organization, and process. He also explores how this emerging unified theory of human behavior implied a troubling similarity between humans and machines, with freighted implications for individual liberty and self-direction. These social scientists trained a generation of decision-makers in schools of business and public administration, wrote the basic textbooks from which millions learned how the economy, society, polity, culture, and even the mind worked, and drafted the position papers, books, and articles that helped set the terms of public discourse in a new era of mass media, think tanks, and issue networks. Drawing on close readings of key texts and a broad survey of more than 1,800 journal articles, Heyck follows the dollars—and the dreams—of a generation of scholars that believed in "the system." He maps the broad landscape of changes in the social sciences, focusing especially intently on the ideas and practices associated with modernization theory, rational choice theory, and modeling. A highly accomplished historian, Heyck relays this complicated story with unusual clarity.
The Age of Wind Energy: Progress and Future Directions from a Global Perspective (Innovative Renewable Energy)
by Ali Sayigh David MilborrowThis unique volume on wind energy features contributions from the world’s leading research and development pioneers in the field of renewable energy. It discusses advances in offshore wind technology, grid-connected systems, grid stabilization and wind turbine design and highlights. Written from an international perspective, chapters focus on the status of wind energy in various regions and countries across the globe, outlining the positive impact its implementation has had on delaying the catastrophic effects of climate change.
The Age of Wonder: How the Romantic Generation Discovered the Beauty and Terror of Science
by Richard HolmesThe Age of Wonder is a colorful and utterly absorbing history of the men and women whose discoveries and inventions at the end of the eighteenth century gave birth to the Romantic Age of Science. When young Joseph Banks stepped onto a Tahitian beach in 1769, he hoped to discover Paradise. Inspired by the scientific ferment sweeping through Britain, the botanist had sailed with Captain Cook in search of new worlds. Other voyages of discovery—astronomical, chemical, poetical, philosophical—swiftly follow in Richard Holmes's thrilling evocation of the second scientific revolution. Through the lives of William Herschel and his sister Caroline, who forever changed the public conception of the solar system; of Humphry Davy, whose near-suicidal gas experiments revolutionized chemistry; and of the great Romantic writers, from Mary Shelley to Coleridge and Keats, who were inspired by the scientific breakthroughs of their day, Holmes brings to life the era in which we first realized both the awe-inspiring and the frightening possibilities of science—an era whose consequences are with us still.BONUS MATERIAL: This ebook edition includes an excerpt from Richard Holmes's Falling Upwards.
The Age of Wood: Our Most Useful Material and the Construction of Civilization
by Roland EnnosA &“smart and surprising&” (Booklist) &“expansive history&” (Publishers Weekly) detailing the role that wood and trees have played in our global ecosystem—including human evolution and the rise and fall of empires—in the bestselling tradition of Yuval Harari&’s Sapiens and Mark Kurlansky&’s Salt.As the dominant species on Earth, humans have made astonishing progress since our ancestors came down from the trees. But how did the descendants of small primates manage to walk upright, become top predators, and populate the world? How were humans able to develop civilizations and produce a globalized economy? Now, in The Age of Wood, Roland Ennos shows for the first time that the key to our success has been our relationship with wood. &“A lively history of biology, mechanics, and culture that stretches back 60 million years&” (Nature) The Age of Wood reinterprets human history and shows how our ability to exploit wood&’s unique properties has profoundly shaped our bodies and minds, societies, and lives. Ennos takes us on a sweeping journey from Southeast Asia and West Africa where great apes swing among the trees, build nests, and fashion tools; to East Africa where hunter gatherers collected their food; to the structural design of wooden temples in China and Japan; and to Northern England, where archaeologists trace how coal enabled humans to build an industrial world. Addressing the effects of industrialization—including the use of fossil fuels and other energy-intensive materials to replace timber—The Age of Wood not only shows the essential role that trees play in the history and evolution of human existence, but also argues that for the benefit of our planet we must return to more traditional ways of growing, using, and understanding trees. A brilliant blend of recent research and existing scientific knowledge, this is an &“excellent, thorough history in an age of our increasingly fraught relationships with natural resources&” (Kirkus Reviews, starred review).
Age Structured Epidemic Modeling (Interdisciplinary Applied Mathematics #52)
by Xue-Zhi Li Junyuan Yang Maia MartchevaThis book introduces advanced mathematical methods and techniques for analysis and simulation of models in mathematical epidemiology. Chronological age and class-age play an important role in the description of infectious diseases and this text provides the tools for the analysis of this type of partial differential equation models. This book presents general theoretical tools as well as large number of specific examples to guide the reader to develop their own tools that they may then apply to study structured models in mathematical epidemiology. The book will be a valuable addition to the arsenal of all researchers interested in developing theory or studying specific models with age structure.
The Ageing Brain
by Prof Lawrence WhalleyHow and why our brains age, and what we can do to prevent brain ageing and mental deterioration.We joke about growing old. From the viewpoint of youth, old age holds few if any rewards - at best those of increased dignity and wisdom. But as Lawrence Whalley shows in this fascinating overview of the ageing brain, we now have cause to be optimistic about old age.In surveying the prospects of slowing or even preventing the worst effects of brain ageing, Whalley looks at the development of the brain and how this is influenced by environmental factors such as diet and stress; the biological and psychological mechanisms of brain injury and disease, and the range of possible treatments and preventatives; individual differences in brain ageing, and the relative roles of nature and nurture in determining our mental abilities.
Ageing, Neuropsychology and the 'New' Dementias: Definitions, Explanations and Practical Approaches (Routledge Library Editions: Aging)
by Una HoldenUp to the 1990s, the influence of brain function disturbances and causes of dementia in the elderly had mostly been overlooked as a possible explanation for antisocial or unusual behaviour. As a result, these had tended not to be included in assessment and training programmes.
Ageing Well: Nutrition, Health, and Social Interventions (Society for the Study of Human Biology)
by Alan D. Dangour Emily M. D. Grundy Astrid E. FletcherMany current public health actions and policies aimed at older people revolve around the often prevailing view that failing health is a consequence of ageing. It is now clear that it is possible to postpone or even prevent much of the age-related decline in health that was once thought inevitable. Future policies must recognise this changing paradi
Ageless: The New Science of Getting Older Without Getting Old
by Andrew SteeleA startling chronicle by a brilliant young scientist takes us onto the frontiers of the science of aging, and reveals how close we are to an astonishing extension of our life spans and a vastly improved quality of life in our later years.Aging--not cancer, not heart disease--is the true underlying cause of most human death and suffering. We accept as inevitable that as we advance in years our bodies and minds begin to deteriorate and that we are ever more likely to be felled by dementia or disease. But we never really ask--is aging necessary? Biologists, on the other hand, have been investigating that question for years. After all, there are tortoises and salamanders whose risk of dying is the same no matter how old they are. With the help of science, could humans find a way to become old without getting frail, a phenomenon known as "biological immortality"?In Ageless, Andrew Steele, a computational biologist and science writer, takes us on a journey through the laboratories where scientists are studying every bodily system that declines with age--DNA, mitochondria, stem cells, our immune systems--and developing therapies to reverse the trend. With bell-clear writing and intellectual passion, Steele shines a spotlight on a little-known revolution already underway.
The Ageless Generation: How Advances in Biomedicine Will Transform the Global Economy
by Alex ZhavoronkovOver the past 20 years, the biomedical research community has been delivering hundreds of breakthroughs expected to extend human lifespan beyond thresholds imaginable today. However, much of this research has not yet been adopted into clinical practice, nor has it been widely publicized. Biomedicine will transform our society forever by allowing people to live longer and to continue working and contributing financially to the economy longer, rather than entering into retirement and draining the economy through pensions and senior healthcare. Old age will become a concept of the past, breakthroughs in regenerative medicine will continue, and an unprecedented boom to the global economy, with an influx of older able-bodied workers and consumers, will be a reality. A leading expert in aging research, author Alex Zhavoronkov provides a helicopter view on the progress science has already made, from repairing tissue damage to growing functional organs from a single cell, and illuminates the possibilities that the scientific and medical community will soon make into realities. The Ageless Generation is an engaging work that causes us to rethink our ideas of age and ability in the modern world.
Agency Theory and Executive Pay: The Remuneration Committee's Dilemma
by Alexander PepperThis new book examines the relationship between agency theory and executive pay. It argues that while Jensen and Meckling (1976) were right in their analysis of the agency problem in public corporations they were wrong about the proposed solutions. Drawing on ideas from economics, psychology, sociology and the philosophy of science, the author explains how standard agency theory has contributed to the problem of executive pay rather than solved it. The book explores why companies should be regarded as real entities not legal fictions, how executive pay in public corporations can be conceptualised as a collective action problem and how behavioral science can help in the design of optimal incentive arrangements. An insightful and revolutionary read for those researching corporate governance, HRM and organisation theory, this useful book offers potential solutions to some of the problems with executive pay and the standard model of agency.
An Agenda for Sustainable Development Research (World Sustainability Series)
by Walter Leal Filho Amanda Lange Salvia Claudio Ruy Portela de VasconcelosThis book involves establishing a set of priorities and a roadmap that can guide scholarly and practical efforts towards sustainability goals. It encourages collaboration across disciplines to address complex sustainability issues that span social, economic, and environmental domains. It also supports the development of robust methodologies for conducting research, including quantitative, qualitative, and mixed methods approaches. But despite the importance of and the need for an agenda for sustainable development research, many efforts are isolated and thematically disconnected. Also, it is difficult to find information on how sustainability research is being undertaken and on the wide range of methods being used. Against this backdrop and in order to facilitate a broad discussion on the contribution of sustainable development research, this book is being produced. The book gathers inputs from universities and research organisations working on matters related to sustainable development research in a variety of contexts. It also provides a platform for the dissemination of information on the latest initiatives, paving the way for technology transfer and networking. Furthermore, the book intends to provide a fertile basis upon which universities, research centres, and practitioners may cooperate more closely in this key area. Last but not least, a further aim of the book is to present methodological approaches and experiences deriving from case studies and projects, which aim to show how sustainability research may be implementing across a range of disciplines. Thanks to its scope and interdisciplinarity, this books makes an excellent reading to everyone interested on sustainability research.
Agent-Based and Individual-Based Modeling
by Steven F. Railsback Volker GrimmAgent-based modeling is a new technique for understanding how the dynamics of biological, social, and other complex systems arise from the characteristics and behaviors of the agents making up these systems. This innovative textbook gives students and scientists the skills to design, implement, and analyze agent-based models. It starts with the fundamentals of modeling and provides an introduction to NetLogo, an easy-to-use, free, and powerful software platform. Nine chapters then each introduce an important modeling concept and show how to implement it using NetLogo. The book goes on to present strategies for finding the right level of model complexity and developing theory for agent behavior, and for analyzing and learning from models. Agent-Based and Individual-Based Modeling features concise and accessible text, numerous examples, and exercises using small but scientific models. The emphasis throughout is on analysis--such as software testing, theory development, robustness analysis, and understanding full models--and on design issues like optimizing model structure and finding good parameter values.The first hands-on introduction to agent-based modeling, from conceptual design to computer implementation to parameterization and analysis Filled with examples and exercises, with updates and supplementary materials at http://www.railsback-grimm-abm-book.com Designed for students and researchers across the biological and social sciences Written by leading practitionersLeading universities that have adopted this book include: Amherst CollegeBrigham Young UniversityCarnegie Mellon UniversityMiami UniversityNorthwestern UniversityOld Dominion UniversityPortland State UniversityRhodes CollegeSusquehanna UniversityUniversity College, DublinUniversity of ArizonaUniversity of South FloridaUniversity of Virginia
Agent-based Modeling For Archaeology: Simulating The Complexity Of Societies
by Stefani Crabtree Iza Romanowska Colin WrenTo fully understand not only the past, but also the trajectories, of human societies, we need a more dynamic view of human social systems. Agent-based modeling (ABM), which can create fine-scale models of behavior over time and space, may reveal important, general patterns of human activity. Agent-Based Modeling for Archaeology is the first ABM textbook designed for researchers studying the human past. Appropriate for scholars from archaeology, the digital humanities, and other social sciences, this book offers novices and more experienced ABM researchers a modular approach to learning ABM and using it effectively. Readers will find the necessary background, discussion of modeling techniques and traps, references, and algorithms to use ABM in their own work. They will also find engaging examples of how other scholars have applied ABM, ranging from the study of the intercontinental migration pathways of early hominins, to the weather–crop–population cycles of the American Southwest, to the trade networks of Ancient Rome. This textbook provides the foundations needed to simulate the complexity of past human societies, offering researchers a richer understanding of the past—and likely future—of our species. The electronic version of this textbook can be downloaded for free at: https://santafeinstitute.github.io/ABMA/
Agent-Based Modeling of Social Conflict: From Mechanisms to Complex Behavior (SpringerBriefs in Complexity)
by Carlos M. LemosThis Brief revisits and extends Epstein's classical agent-based model of civil violence by considering important mechanisms suggested by social conflict theories. Among them are: relative deprivation as generator of hardship, generalized vanishing of the risk perception ('massive fear loss') when the uprisings surpass a certain threshold, endogenous legitimacy feedback, and network influence effects represented by the mechanism of dispositional contagion. The model is explored in a set of computer experiments designed to provide insight on how mechanisms lead to increased complexity of the solutions. The results of the simulations are compared with statistical analyses of estimated size, duration and recurrence of large demonstrations and riots for eight African countries affected by the "Arab Spring," based on the Social Conflict Analysis Database. It is shown that the extensions to Epstein's model proposed herein lead to increased "generative capacity" of the agent-based model (i. e. a richer set of meaningful qualitative behaviors) as well the identification of key mechanisms and associated parameters with tipping points. The use of quantitative information (international indicators and statistical analyses of conflict events) allows the assessment of the plausibility of input parameter values and simulated results, and thus a better understanding of the model's strengths and limitations. The contributions of the present work for understanding how mechanisms of large scale conflict lead to complex behavior include a new form of the estimated arrest probability, a simple representation of political vs economic deprivation with a parameter which controls the `sensitivity' to value, endogenous legitimacy feedback, and the effect of network influences (due to small groups and "activists"). In addition, the analysis of the Social Conflict Analysis Database provided a quantitative description of the impact of the "Arab Spring" in several countries focused on complexity issues such as peaceful vs violent, spontaneous vs organized, and patterns of size, duration and recurrence of conflict events in this recent and important large-scale conflict process. This book will appeal to students and researchers working in these computational social science subfields.
Agent-Based Semantic Web Service Composition (SpringerBriefs in Electrical and Computer Engineering)
by Sandeep KumarAgent-based Semantic Web Service Composition closely examines the various aspects of SWS composition, and explores the concept that a Multi-Agent system can serve as an SWS composition system in which its agents can interact with one another to satisfy a high-level goal. In addition to surveying various proposed multi-agent-based SWS composition models, the book also highlights the cognitive parameter-based semantic web service selection models that can be used in multi-agent-based SWS composition, and outlines a new negotiation agreement-based SWS composition that can outperform existing techniques. Agent-based Semantic Web Service Composition is intended for researchers and practitioners as a reference guide for optimizing SWS composition and implementing multi-agent systems. Instructors and other academics working in a related field will also find the book invaluable.
Agent Orange: History, Science, and the Politics of Uncertainty
by Edwin A. MartiniTaking on what one former U.S. ambassador called "the last ghost of the Vietnam War," this book examines the far-reaching impact of Agent Orange, the most infamous of the dioxin-contaminated herbicides used by American forces in Southeast Asia. Edwin A. Martini's aim is not simply to reconstruct the history of the "chemical war" but to investigate the ongoing controversy over the short- and long-term effects of weaponized defoliants on the environment of Vietnam, on the civilian population, and on the troops who fought on both sides. Beginning in the early 1960s, when Agent Orange was first deployed in Vietnam, Martini follows the story across geographical and disciplinary boundaries, looking for answers to a host of still unresolved questions. What did chemical manufacturers and American policymakers know about the effects of dioxin on human beings, and when did they know it? How much do scientists and doctors know even today? Should the use of Agent Orange be considered a form of chemical warfare? What can, and should, be done for U.S. veterans, Vietnamese victims, and others around the world who believe they have medical problems caused by Agent Orange? Martini draws on military records, government reports, scientific research, visits to contaminated sites, and interviews to disentangle conflicting claims and evaluate often ambiguous evidence. He shows that the impact of Agent Orange has been global in its reach affecting individuals and communities in New Zealand, Australia, Korea, and Canada as well as Vietnam and the United States. Yet for all the answers it provides, this book also reveals how much uncertainty--scientific, medical, legal, and political--continues to surround the legacy of Agent Orange.
Agent_Zero: Toward Neurocognitive Foundations for Generative Social Science (Princeton Studies in Complexity #25)
by Joshua M. EpsteinThe Final Volume of the Groundbreaking Trilogy on Agent-Based ModelingIn this pioneering synthesis, Joshua Epstein introduces a new theoretical entity: Agent_Zero. This software individual, or "agent," is endowed with distinct emotional/affective, cognitive/deliberative, and social modules. Grounded in contemporary neuroscience, these internal components interact to generate observed, often far-from-rational, individual behavior. When multiple agents of this new type move and interact spatially, they collectively generate an astonishing range of dynamics spanning the fields of social conflict, psychology, public health, law, network science, and economics.Epstein weaves a computational tapestry with threads from Plato, Hume, Darwin, Pavlov, Smith, Tolstoy, Marx, James, and Dostoevsky, among others. This transformative synthesis of social philosophy, cognitive neuroscience, and agent-based modeling will fascinate scholars and students of every stripe. Epstein's computer programs are provided in the book or on its Princeton University Press website, along with movies of his "computational parables.?Agent_Zero is a signal departure in what it includes (e.g., a new synthesis of neurally grounded internal modules), what it eschews (e.g., standard behavioral imitation), the phenomena it generates (from genocide to financial panic), and the modeling arsenal it offers the scientific community. For generative social science, Agent_Zero presents a groundbreaking vision and the tools to realize it.