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Epigenetics: How Environment Shapes Our Genes
by Richard C. FrancisGoodbye, genetic blueprint. . . . The first book for general readers ?on the game-changing field of epigenetics. The burgeoning new science of epigenetics offers a cornucopia of insights--some comforting, some frightening. For example, the male fetus may be especially vulnerable to certain common chemicals in our environment, in ways that damage not only his own sperm but also the sperm of his sons. And it's epigenetics that causes identical twins to vary widely in their susceptibility to dementia and cancer. But here's the good news: unlike mutations, epigenetic effects are reversible. Indeed, epigenetic engineering is the future of medicine.
Epigenetics: Linking Genotype and Phenotype in Development and Evolution
by Benedikt Hallgrímsson Brian K. HallIlluminating the processes and patterns that link genotype to phenotype, epigenetics seeks to explain features, characters, and developmental mechanisms that can only be understood in terms of interactions that arise above the level of the gene. With chapters written by leading authorities, this volume offers a broad integrative survey of epigenetics. Approaching this complex subject from a variety of perspectives, it presents a broad, historically grounded view that demonstrates the utility of this approach for understanding complex biological systems in development, disease, and evolution. Chapters cover such topics as morphogenesis and organ formation, conceptual foundations, and cell differentiation, and together demonstrate that the integration of epigenetics into mainstream developmental biology is essential for answering fundamental questions about how phenotypic traits are produced.
Epigenetics: The Ultimate Mystery of Inheritance
by Richard C. FrancisA writer with a PhD in neurobiology explains why "identical" twins can have different risks for health problems, how the effects of famine can be inherited across generations, and the dynamics of the breeding of hybrid animals. Francis presents an interesting, accessible introduction to epigenetics, a new field that studies how the environment (prenatal, social, and chemical stressors) can have long-term physiological and behavioral effects through regulating genes. He explains how this process offers promise for understanding development and obesity, and treating cancer. Annotation ©2011 Book News, Inc., Portland, OR (booknews.com)
Epigenetik des Menschen
by Carsten Carlberg Ferdinand MolnárDie Ansicht „Es liegt alles in unseren Genen und wir können es nicht ändern“ hat sich in den letzten 150 Jahren seit Gregor Mendels Experimenten mit blühenden Erbsenpflanzen entwickelt. Es gibt jedoch eine besondere Form der Genetik, die Epigenetik, bei der unsere Gene nicht verändert werden, sondern geregelt wird, wie und wann sie genutzt werden. Unsere Umwelt und Lebensstilentscheidungen beeinflussen die Epigenetik unserer Zellen und Organe, d. h. die Epigenetik verändert sich dynamisch während unseres gesamten Lebens. Wir haben also die Möglichkeit, unsere Epigenetik sowohl positiv als auch negativ zu verändern.In diesem Buch wird auf molekularer Ebene erklärt, wie unser Genom mit Umweltsignalen verbunden ist. Es zeigt auf, dass die epigenetische Programmierung ein Lernprozess ist, der zu einem epigenetischen Gedächtnis in jeder Zelle unseres Körpers führt. Die zentrale Bedeutung der Epigenetik während der Embryogenese und der zellulären Differenzierung sowie beim Alterungsprozess und dem Risiko für die Entstehung von Krebs werden erörtert. Darüber hinaus wird die Rolle des Epigenoms als molekularer Speicher für zelluläre Ereignisse nicht nur im Gehirn, sondern auch in Stoffwechselorganen und im Immunsystem beschrieben.Das Buch ist die Übersetzung des Lehrbuchs „Human Epigenetics: How Science Works“ (ISBN 978-3-030-22907-8) der Autoren. In den ersten fünf Kapiteln werden die molekularen Grundlagen der Epigenetik erläutert, während die folgenden sieben Kapitel Beispiele für die Auswirkungen der Epigenetik auf die menschliche Gesundheit und Krankheit liefern.
Epigenetische Mechanismen der Zellprogrammierung und Zellreprogrammierung
by Gang PeiDieses Buch stellt ein umfangreiches Forschungsprogramm zu epigenetischen Mechanismen der Zellprogrammierung und Reprogrammierung vor. Das Programm wurde von der National Natural Science Foundation of China während des 11. Fünfjahresplans gestartet, der im Oktober 2008 begann und Ende 2016 abgeschlossen wurde. Es fasst zunächst die epigenetischen Forschungspläne und den aktuellen Stand der epigenetischen Forschung in China und im internationalen Vergleich zusammen. Unter Anwendung interdisziplinärer Forschungsmethoden erörtert das Buch die Entwicklungstrends der epigenetischen Forschung, wie die Mechanismen der Etablierung und Aufrechterhaltung epigenetischer Informationen und die epigenetische Regulierung von Reproduktion und Entwicklung. Außerdem wird eine Vielzahl von Forschungsergebnissen vorgestellt. So werden beispielsweise die Entdeckung neuer epigenetischer Regulatoren und Chromatin-Remodulatoren sowie deren biologische Funktionen und Mechanismen hervorgehoben. Es werden verschiedene Regulierungsmechanismen der Zelldifferenzierung und Transdifferenzierung erörtert, insbesondere die Entdeckung der Schlüsselfaktoren zur Förderung der Transdifferenzierung von Körperzellen zu Hepatozyten. Darüber hinaus werden in diesem Buch einige wichtige akademische Bereiche mit zunehmender Bedeutung vorgestellt, wie Biochemie, Zellbiologie und klinische Medizin. Aufgrund seines Umfangs ist das Buch für Forscher interessant, die in den Bereichen Zellbiologie, Biochemie, Strukturbiologie, Bioinformatik, klinische Medizin und anderen verwandten Gebieten arbeiten.
Epigenome Editing: Methods And Protocols (Methods In Molecular Biology #1767)
by Albert Jeltsch Marianne G. RotsThis detailed book explores the concepts and applications of epigenome editing, as presented by leading scientists in the field. Beginning with some general and topical reviews, the collection continues by covering the design of DNA-binding devices, optimization of the effector domains, readout of epigenome marks, and approaches for delivery at the cellular and organismal level. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Epigenome Editing: Methods and Protocols will be of great assistance to people new to the field but also to those already engaged, as epigenetic editing is still a relatively unexplored field with many issues to be resolved.
Epigenome Editing: Methods and Protocols (Methods in Molecular Biology #2842)
by Albert Jeltsch Marianne G. RotsThis second volume details new and updated methods covering applications of epigenome editing. Chapters guide readers through general and topical reviews, DNA-binding devices, optimization of the effector domains, readout of epigenome marks, and approaches for delivery at the cellular and organismal level. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Epigenome Editing: Methods and Protocols, Second Editon aims to ensure successful results in the further study of this vital field.
Epigenomics
by Krishnarao Appasani Azim SuraniUnderstanding mechanisms of gene regulation that are independent of the DNA sequence itself – epigenetics – has the potential to overthrow long-held views on central topics in biology, such as the biology of disease or the evolution of species. High throughput technologies reveal epigenetic mechanisms at a genome-wide level, giving rise to epigenomics as a new discipline with a distinct set of research questions and methods. Leading experts from academia, the biotechnology and pharmaceutical industries explain the role of epigenomics in a wide range of contexts, covering basic chromatin biology, imprinting at a genome-wide level, and epigenomics in disease biology and epidemiology. Details on assays and sequencing technology serve as an up-to-date overview of the available technological tool kit. A reliable guide for newcomers to the field as well as experienced scientists, this is a unique resource for anyone interested in applying the power of twenty-first-century genomics to epigenetic studies.
Epigenomics: Methods and Protocols (Methods in Molecular Biology #2577)
by Izuho Hatada Takuro HoriiThis detailed volume provides a comprehensive collection of protocols for epigenomic research, powering our ability to analyze epigenetic modifications across the entire genome. Beginning with methods used to investigate epigenomic modifications such as DNA methylation, histone modifications, and chromatin structure, the book continues with methods for manipulating the epigenome, including platforms for epigenome editing, inducible systems for epigenome editing, and epigenetically modified animals. Written for the highly successful Methods in Molecular Biology series, chapters feature introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Epigenomics: Methods and Protocols serves as an ideal resource for researchers looking to further expand the utility and scope of epigenomics research.
Epilepsy Fundamentals: A Concise Clinical Guide
by Zulfi HaneefThere is a considerable need for a concise handbook available for the student of epilepsy. Epilepsy is a rapidly evolving field and the available books are large, unwieldy and infrequently updated. This book fills this need by providing a concise review on the evolving field of epilepsy. It's aimed for the medical student or resident rotating through epilepsy and EEG, a fellow preparing for the ABPN epilepsy board, or an epilepsy specialist seeking to quickly brush up your knowledge in the field. Chapters cover the critical areas of classification, EEG, clinical features, medication management, surgical management, and other topics. This books brings the latest research and best practices together into a streamlined resource, offering a personal touch stemming from the experience of academic epileptologists.
Epilepsy in the Tropics
by J.M.K. MurthyThis book focuses on epidemiology, diagnosis, symptomatology, clinical biology, treatment, economics, and health care. It will be a guidebook for professionals in tropical countries engaged in the care of people with epilepsy.
Epilepsy: Mechanisms, Models, and Translational Perspectives
by Jong M. Rho Raman SankarEpilepsy has afflicted humankind throughout recorded history; yet, it is only in the last half-century, that significant progress has been made in our basic understanding of the epileptic brain. Pivotal advances in drug development and surgical techniques, as well as the emergence of innovative approaches such as electrical stimulation of the nervo
Epilepsy: The Intersection of Neurosciences, Biology, Mathematics, Engineering, and Physics
by Ivan Osorio Hitten P. Zaveri Mark G. Frei Susan ArthursEpilepsy, one of the most prevalent neurological disorders, affects approximately 1% (greater than 60 million) of the world's population. In an estimated 20 million of these patients, seizures are not controlled even by multiple anti-seizure drugs, and are extremely difficult to predict. Epilepsy: The Intersection of Neurosciences, Biology, Mathema
Epileptic Seizure Prediction Using Electroencephalogram Signals
by Ratnaprabha Ravindra Borhade Vinayak K. Bairagi Manoj S. Nagmode Ravindra Honaji BorhadeThis book presents an innovative method of EEG-based feature extraction and classification of seizures using EEG signals. It describes the methodology required for EEG analysis, seizure detection, seizure prediction, and seizure classification. It contains a compilation of techniques described in the literature and emphasizes newly proposed techniques. The book includes a brief discussion of existing methods for epileptic seizure diagnosis and prediction and introduces new efficient methods specifically for seizure prediction. Focuses on the mathematical models and machine learning algorithms from a perspective of clinical deployment of EEG-based epileptic seizure prediction Discusses recent trends in seizure detection, prediction, and classification methodologies Provides engineering solutions to severity or risk analysis of detected seizures at remote places Presents wearable solutions to seizure prediction Includes details of the use of deep learning for epileptic seizure prediction using EEG This book acts as a reference for academicians and professionals who are working in the field of computational biomedical engineering and are interested in the domain of EEG-based disease prediction.
Epileptic Seizures and the EEG: Measurement, Models, Detection and Prediction
by Mark Cook Andrea Varsavsky Iven MareelsA study of epilepsy from an engineering perspective, this volume begins by summarizing the physiology and the fundamental ideas behind the measurement, analysis and modeling of the epileptic brain. It introduces the EEG and provides an explanation of the type of brain activity likely to register in EEG measurements, offering an overview of how these EEG records are and have been analyzed in the past. The book focuses on the problem of seizure detection and surveys the physiologically based dynamic models of brain activity. Finally, it addresses the fundamental question: can seizures be predicted? Based on the authors' extensive research, the book concludes by exploring a range of future possibilities in seizure prediction.
Epiphany Z: 8 Radical Visions for Transforming Your Future
by Thomas Frey"Epiphany Z" is Futurist Thomas Frey&’s dynamic approach to envisioning, comprehending, and ultimately thriving in the radically different futures emerging around us at the speed of light. Frey&’s unparalleled ability to detect emerging trends from the smallest of clues gives him an edge on other futurists. Now he&’s sharing that edge with you.What are tomorrow&’s hottest industries?What huge industries of today are doomed to extinction?How will our lives be changed by advancements in robotics, in drone technology, in manufacturing and transportation?How can education cope with the explosive new world of enhanced information, hyperactive business environments, cultural shifts that would have been unimaginable as recently as yesterday?Who will be the masters of tomorrow&’s universe and who will be left behind?Above all, how can you not only protect yourself from the most disruptive aspects of the changes sweeping your way---how can you become one of the masters of those changes?Distilling decades of research, experience, and proven success in correctly identifying and accurately extrapolating today&’s trends and innovations into tomorrow&’s realities, Thomas Frey gives you an advance ticket to the most explosive period of change in all of human history.Those changes are taking place now. Thomas Frey shows where they will be taking all of us tomorrow. "EPIPHANY Z" your roadmap to the future.
Epistasis
by Jason H. Moore Scott M. WilliamsThis volume presents a valuable and readily reproducible collection of established and emerging techniques on modern genetic analyses. Chapters focus on statistical or data mining analyses, genetic architecture, the burden of multiple testing, genetic variance, measuring epistasis, multifactor dimensionality reduction, and ReliefF. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Epistasis: Methods and Protocols aids scientists in continuing to study elucidate epistasis in the context of modern data availability.
Epistemic Complexity and Knowledge Construction
by A. CarsettiThe volume as its first target aims at clarifying that peculiar entanglement of complexity, causality, meaning, emergence and intentionality that characterises the unfolding of the "natural forms" of human cognition As is well known, cognition is not only a self-organising process. It is also a co-operative and coupled process. If we consider the external environment as a complex, multiple and stratified Source which interacts with the nervous system, we can easily realise that the cognitive activities devoted to the "intelligent" search for the depth information living in the Source, may determine the very change of the complexity conditions according to which the Source progressively expresses its "wild" action. In this sense, simulation models are not neutral or purely speculative: the true cognition actually appears to be necessarily connected with successful forms of reading, those forms, in particular, that permit a specific coherent unfolding of the deep information content of the Source. Therefore, the simulation models, if valid, materialise as "creative" channels, i.e., as autonomous functional systems, as the very roots of a new possible development of the entire system represented by mind and its Reality. From a general point of view, the objectivity of Reality is also proportionate to the autonomy reached by cognitive processes. In this sense, at the level of cultural evolution, reference procedures act as guide, mirror and canalisation with respect to primary information flows and involved selective forces: they offer themselves as the actual instruments for the constant renewal of the code, for the invention and the actual articulation of an ever-new incompressibility. From an effective point of view, they appear as indissolubly linked to the successive definition of specific (and innovative) measures of the epistemic complexity. These measures cannot concern only statistical rarity (Shannon) or computational incompressibility (Kolmogorov-Chaitin), on the contrary they should also be able to take into account the coupled connection between the Source and the cognitive agent, the evolution of this connection as well as the successive constitution of meaning as symbolic form. Hence the possible (and necessary) definition of new axiomatic systems, new measure spaces, the real displaying of processes of continuous reorganisation at the semantic level. Indeed, it is only through a complete, first-order "reduction" and a correlated non-standard second-order analysis that new incompressibility will actually manifest itself. Therefore, the reference procedures appear to be related to a process of multiplication of minds, as well as to a process of "clarification" of meanings which finally emerges as vision via principles.
Epistemic Processes: A Basis for Statistics and Quantum Theory
by Inge S. HellandThis book discusses a link between statistical theory and quantum theory based on the concept of epistemic processes – which can be e.g. statistical investigations or quantum mechanical measurements, and refer to processes that are used to gain knowledge about something. The book addresses a range of topics, including a derivation of the Born formula from reasonable assumptions, a derivation of the Schrödinger equation in the one-dimensional case, and a discussion of the Bell inequality from an epistemic perspective. The book describes a possible epistemic foundation of quantum theory. Lastly, it presents a general philosophical discussion of the approach, which, principally speaking, is not restricted to the micro-world. Hence the book can also be seen as a motivation for further research into quantum decision theory and quantum models for cognition. The book will benefit a broad readership, including physicists and statisticians interested in the foundation of their disciplines, philosophers of science and graduate students, and anyone with a reasonably good background in mathematics and an open mind.
Epistemic Processes: A Basis for Statistics and Quantum Theory
by Inge S. HellandThis book discusses a link between statistical theory and quantum theory based on the concept of epistemic processes. The latter are processes, such as statistical investigations or quantum mechanical measurements, that can be used to obtain knowledge about something. Various topics in quantum theory are addressed, including the construction of a Hilbert space from reasonable assumptions and an interpretation of quantum states. Separate derivations of the Born formula and the one-dimensional Schrödinger equation are given. In concrete terms, a Hilbert space can be constructed under some technical assumptions associated with situations where there are two conceptual variables that can be seen as maximally accessible. Then to every accessible conceptual variable there corresponds an operator on this Hilbert space, and if the variables take a finite number of values, the eigenspaces/eigenvectors of these operators correspond to specific questions in nature together with sharp answers to these questions. This paves a new way to the foundations of quantum theory. The resulting interpretation of quantum mechanics is related to Hervé Zwirn's recent Convivial Solipsism, but it also has some relations to Quantum Bayesianism and to Rovelli's relational quantum mechanics. Niels Bohr's concept of complementarity plays an important role. Philosophical implications of this approach to quantum theory are discussed, including consequences for macroscopic settings.The book will benefit a broad readership, including physicists and statisticians interested in the foundations of their disciplines, philosophers of science and graduate students, and anyone with a reasonably good background in mathematics and an open mind.
Epistemology and Probability
by Arkady PlotnitskyThe book offers an exploration of the relationships between epistemology and probability in the work of Niels Bohr, Werner Heisenberg, and Erwin Schrödinger; in quantum mechanics; and in modern physics as a whole. It also considers the implications of these relationships and of quantum theory itself for our understanding of the nature of thinking and knowledge in general. These implications are radical and controversial. While they have been seen as scientifically productive and intellectually liberating to some, Bohr and Heisenberg among them, they have been troublesome to many others, beginning with Schrödinger and, most famously, Einstein, who refused to believe that God would resort to playing dice, as quantum theory appeared to demand. The situation led to an intense debate, in particular the great confrontation between Einstein and Bohr, which began around the time of the discovery of quantum mechanics by Heisenberg and Schrödinger in 1920s and has overshadowed the history of the debate concerning quantum mechanics ever since. The controversy itself surrounding quantum theory and the intensity of the debate concerning it have remained undiminished. No end appears to be in sight. At the same time, in spite of the enormous and ever proliferating amount of commentaries in all genres (technical, philosophical, and popular), some of the deeper philosophical aspects of quantum mechanics and of the philosophical thought of the figures considered in this study often remain explored. The main aim of this book is to contribute to a better understanding of the nature of quantum-theoretical thinking and of the reasons for this extraordinary impact and controversy. Philosophically, the book pursues this task by bringing together in a new way the relationships between epistemology and probability in quantum theory and beyond. Historically, it does so by engaging comprehensively and in a mutually illuminating way with the work of all three key figures responsible for the birth of quantum mechanics - Heisenberg, Schrödinger, and, as concerns quantum epistemology, Bohr - which has not be previously done in literature on quantum mechanics. Among other key contributions of the book is an analysis of the role of mathematics in quantum theory and in the thinking of Bohr, Heisenberg, and Schrödinger; a new treatment of the famous experiment of Einstein, Podolsky, and Rosen (EPR) and of the Bohr-Einstein exchange concerning it; and an exploration of the implications of the epistemological problematics considered by the book for new developments of quantum mechanics itself, such as quantum information theory, on the one hand, and, on the other, for higher-level physical theories, from quantum field theory to string/brane theories and new cosmological theories.
Epistemology and Science Education: Understanding the Evolution vs. Intelligent Design Controversy
by Michel Ferrari Roger S. TaylorHow is epistemology related to the issue of teaching science and evolution in the schools? Addressing a flashpoint issue in our schools today, this book explores core epistemological differences between proponents of intelligent design and evolutionary scientists, as well as the critical role of epistemological beliefs in learning science. Preeminent scholars in these areas report empirical research and/or make a theoretical contribution, with a particular emphasis on the controversy over whether intelligent design deserves to be considered a science alongside Darwinian evolution. This pioneering book coordinates and provides a complete picture of the intersections in the study of evolution, epistemology, and science education, in order to allow a deeper understanding of the intelligent design vs. evolution controversy. This is a very timely book for teachers and policy makers who are wrestling with issues of how to teach biology and evolution within a cultural context in which intelligent design has been and is likely to remain a challenge for the foreseeable future.
Epistemology of Decision
by Mario GrazianoThis book carries out an epistemological analysis of the decision, including a critical analysis through the continuous reference to an interdisciplinary approach including a synthesis of philosophical approaches, biology and neuroscience. Besides this it represents the analysis of causality here seen not from the formal point of view, but from the "embodied" point of view.
Epistemology of Experimental Physics (Elements in the Philosophy of Physics)
by Nora Mills BoydThis Element introduces major issues in the epistemology of experimental physics through discussion of canonical physics experiments and some that have not yet received much philosophical attention. The primary challenge is to make sense of how physicists justify crucial decisions made in the course of empirical research. Judging a result as epistemically significant or as calling for further technical scrutiny of the equipment is one important context of such decisions. Judging whether the instrument has been calibrated, and which data should be included in the analysis are others. To what extent is it possible to offer philosophical analysis, systematization, and prescriptions regarding such decisions? To what extent can there be explicit epistemic justification for them? The primary aim of this Element is to show how a nuanced understanding of science in practice informs an epistemology of experimental physics that avoids strong social constructivism.
Epistemology of the Cell: A Systems Perspective on Biological Knowledge
by Edward R. Dougherty Michael L. BittnerIn the era of high biological data throughput, biomedical engineers need a more systematic knowledge of the cell in order to perform more effective data handling. Epistemology of the Cell is the first authored book to break down this knowledge. This text examines the place of biological knowledge within the framework of science as a whole and addresses issues focused on the specific nature of biology, how biology is studied, and how biological knowledge is translated into applications, in particular with regard to medicine. The book opens with a general discussion of the historical development of human understanding of scientific knowledge, the scientific method, and the manner in which scientific knowledge is represented in mathematics. The narrative then gets specific for biology, focusing on knowledge of the cell, the basic unit of life. The salient point is the analogy between a systems-based analysis of factory regulation and the regulation of the cell. Each chapter represents a key topic of current interest, including: Causality and randomness Translational science Stochastic validation: classification Stochastic validation: networks Model-based experimentation in biology Epistemology of the Cell is written for biomedical researchers whose interests include bioinformatics, biological modeling, biostatistics, and biological signal processing.