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Epitope Mapping Protocols (Methods in Molecular Biology #1785)
by Johan Rockberg Johan NilvebrantThis third edition volume expands on the previous editions with more detailed research on the characterization of antibody antigen interactions between different users with different requirements. The chapters in this book are divided into four parts: Part One looks at the entire native antigen and covers traditional structural biology techniques such as nuclear magnetic resonance and x-ray crystallography. Part Two talks about protein fragments derived from antigens, and discusses binding regions within antigen sequence using bacterial surface display and ELISA, for example. Part Three describes the use of surface plasmon resonance spectroscopy and biolayer interferometry, and Part Four highlights methods used to identify new antigens and assess antibody cross-reactivity. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Thorough and cutting-edge, Epitope Mapping Protocols, Third Edition is a valuable resource for anyone interested in furthering their research in this expanding field.
Epitranscriptomics (RNA Technologies #12)
by Jan Barciszewski Stefan JurgaThis book reviews a novel and exciting field of cellular and molecular biology called epitranscriptomics, which focuses on changes in an organism’s cells resulting from the posttranscriptional modification of cellular RNA. RNA-binding proteins (RBPs) play a crucial role in these posttranscriptional modifications and also support several cellular processes necessary for maintaining RNA homeostasis. Exploring the mechanisms underlying RNA modifications and RBP function is an emerging area of biomedical research, taking the study of gene regulation a step beyond epigenetics. This book reveals that the RNA molecule is not just an information-carrying molecule with some secondary structures. Accordingly, how RNA is modified, regulated, packaged, and controlled is an important aspect. Leading experts address questions such as where the over 170 distinct posttranscriptional RNA modifications are located on the genome, what percentage of mRNAs and noncoding RNAs these modifications include, and how an RNA modification impacts a person’s biology. In closing, the book reviews the role of RNA modifications and RBPs in a variety of diseases and their pathogenesis. Addressing some of the most exciting challenges in epitranscriptomics, this book provides a valuable and engaging resource for researchers in academia and industry studying the phenomena of RNA modification.
Epizootic Hemorrhagic Disease Virus: Methods and Protocols (Methods in Molecular Biology #2838)
by Carrie BattenThis volume provides detailed methods to support fast and reliable diagnosis, surveillance and control of Epizootic Haemorrhagic disease virus (EHDV), with the aim of facilitating and promoting further research into this understudied Orbivirus. Chapters guide readers through methods to enable the characterization of EHDV in vitro and in vivo. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Epizootic Hemorrhagic Disease Virus: Methods and Protocols aims to be a useful up-to-date reference work for researchers currently in the field and to those entering the field.
Epoxidations and Hydroperoxidations of α,β-Unsaturated Ketones
by Corinna ReisingerCorinna Reisinger has developed a new organocatalytic asymmetric epoxidation of cyclic and acyclic α,β-unsaturated ketones. In this thesis, Corinna documents her methodology, using primary amine salts as catalysts, and hydrogen peroxide as an inexpensive and environmentally benign oxidant. She describes the unprecedented and powerful catalytic asymmetric hydroperoxidation of α,β-enones, a process which produces optically active five-membered cyclic peroxyhemiketals in a single operation. She also proves the versatility and synthetic value of the cyclic peroxyhemiketals by converting them into highly enantioenriched acyclic and cyclic aldol products. Currently, these cyclic aldol products are inaccessible by any other synthetic means. Furthermore, cyclic peroxyhemiketals are precursors to optically active 1,2-dioxolanes which are of biological relevance. This work is a breakthrough in the field of asymmetric epoxidation chemistry and outlines the most efficient method in the literature for generating highly enantioselective cyclic epoxyketones known to date.
Epoxidised Natural Rubber: Properties & Applications
by Siti Salina Sarkawi Fatimah Rubaizah Mohd Rasdi Veronica CharlotteThis book is a complete guide to epoxidized natural rubber covering from the epoxidation chemistry, production process, raw rubber and compound properties, mixing recommendations as its applications in tire, engineering, general and industrial rubber goods, latex based products such as adhesive, foam and paint as well as sustainability or life cycle analysis of ENR rubber. Hence, it is useful for readers either from the industry which looking for specific product application and properties, or scientists and academicians working on their research using the ENR in their study for reference and guidance.
Epoxy Resins: Chemistry and Technology, Second Edition,
by Clayton A. MayFeaturing new techniques of physicochemical analysis and broader coverage of textile applications,the thoroughly rewritten and enlarged Second Edition provides hands-on assistance inthe use, formulation, synthesis, processing, and handling of epoxy resins.Epoxy Resins, Second Edition, Revised and Expanded documents available commercialproducts, including rarer species of epoxides ... shows how to achieve qualityassurance through analytical methods ... discusses toxicity, hazards, and safe handling ...looks closely at elastomer modification of resins as well as adhesives, coatings, electrical andelectronic applications, fiber-reinforced composites, and the use of epoxy resins in thestabilization of polymers, plasticizers, and textiles ... and assists in the more efficientselection and application of epoxy resins.Complete with nearly 300 pages of tables for quick references, plus over 300 diagrams andphotographs, and more than 4,400 bibliographic references, this volume will proveindispensable to polymer, physical, and organic chemists, rheologists, materials scientists andengineers, and chemical, plastics, aerospace, automotive, and electrical and electronicsengineers.
Eppur si muove: Doing History and Philosophy of Science with Peter Machamer
by Jacqueline A. Sullivan Uljana Feest Marcus P. Adams Zvi BienerThis volume is a collection of original essays focusing on a wide range of topics in the History and Philosophy of Science. It is a festschrift for Peter Machamer, which includes contributions from scholars who, at one time or another, were his students. The essays bring together analyses of issues and debates spanning from early modern science and philosophy through the 21st century. Machamer's influence is reflected in the volume's broad range of topics. These include: underdetermination, scientific practice, scientific models, mechanistic explanation in contemporary and historical science, values in science, the relationship between philosophy and psychology, experimentation, supervenience and reductionism.
Equations from God: Pure Mathematics and Victorian Faith (Johns Hopkins Studies in the History of Mathematics)
by Daniel J. CohenThroughout history, application rather than abstraction has been the prominent driving force in mathematics. From the compass and sextant to partial differential equations, mathematical advances were spurred by the desire for better navigation tools, weaponry, and construction methods. But the religious upheaval in Victorian England and the fledgling United States opened the way for the rediscovery of pure mathematics, a tradition rooted in Ancient Greece.In Equations from God, Daniel J. Cohen captures the origins of the rebirth of abstract mathematics in the intellectual quest to rise above common existence and touch the mind of the deity. Using an array of published and private sources, Cohen shows how philosophers and mathematicians seized upon the beautiful simplicity inherent in mathematical laws to reconnect with the divine and traces the route by which the divinely inspired mathematics of the Victorian era begot later secular philosophies.
Equations of Motion in Relativistic Gravity
by Bernard Schutz Dirk Puetzfeld Claus LämmerzahlThe present volume aims to be a comprehensive survey on the derivation of the equations of motion, both in General Relativity as well as in alternative gravity theories. The topics covered range from the description of test bodies, to self-gravitating (heavy) bodies, to current and future observations. Emphasis is put on the coverage of various approximation methods (e. g. , multipolar, post-Newtonian, self-force methods) which are extensively used in the context of the relativistic problem of motion. Applications discussed in this volume range from the motion of binary systems -- and the gravitational waves emitted by such systems -- to observations of the galactic center. In particular the impact of choices at a fundamental theoretical level on the interpretation of experiments is highlighted. This book provides a broad and up-do-date status report, which will not only be of value for the experts working in this field, but also may serve as a guideline for students with background in General Relativity who like to enter this field.
Equations of Motion in Relativistic Gravity (Fundamental Theories of Physics #179)
by Bernard Schutz Dirk Puetzfeld Claus LämmerzahlThe present volume aims to be a comprehensive survey on the derivation of the equations of motion, both in General Relativity as well as in alternative gravity theories. The topics covered range from the description of test bodies, to self-gravitating (heavy) bodies, to current and future observations.Emphasis is put on the coverage of various approximation methods (e.g., multipolar, post-Newtonian, self-force methods) which are extensively used in the context of the relativistic problem of motion. Applications discussed in this volume range from the motion of binary systems -- and the gravitational waves emitted by such systems -- to observations of the galactic center. In particular the impact of choices at a fundamental theoretical level on the interpretation of experiments is highlighted.This book provides a broad and up-do-date status report, which will not only be of value for the experts working in this field, but also may serve as a guideline for students with background in General Relativity who like to enter this field.
Equatorial Electrojet
by CAgodi OnwumechikliThis is the first book to review all the fields of equatorial electrojet phenomena and their relevant theories in one volume. In certain relevant sections, the book discusses both the equatorial electrojet and the world-wide parts of the Sq current systems. Onwumwchili is an internationally known and highly respected expert in the equatorial electrojet field- a brand of geomagnetism.
Equilibria and Kinetics of Biological Macromolecules
by Jan Hermans Barry LentzProgressively builds a deep understanding of macromolecular behaviorBased on each of the authors' roughly forty years of biophysics research and teaching experience, this text instills readers with a deep understanding of the biophysics of macromolecules. It sets a solid foundation in the basics by beginning with core physical concepts such as thermodynamics, quantum chemical models, molecular structure and interactions, and water and the hydrophobic effect. Next, the book examines statistical mechanics, protein-ligand binding, and conformational stability. Finally, the authors address kinetics and equilibria, exploring underlying theory, protein folding, and stochastic models.With its strong emphasis on molecular interactions, Equilibria and Kinetics of Biological Macromolecules offers new insights and perspectives on proteins and other macromolecules. The text features coverage of:Basic theory, applications, and new research findingsRelated topics in thermodynamics, quantum mechanics, statistical mechanics, and molecular simulationsPrinciples and applications of molecular simulations in a dedicated chapter and interspersed throughout the textMacromolecular binding equilibria from the perspective of statistical mechanicsStochastic processes related to macromoleculesSuggested readings at the end of each chapter include original research papers, reviews and monographs, enabling readers to explore individual topics in greater depth. At the end of the text, ten appendices offer refreshers on mathematical treatments, including probability, computational methods, Poisson equations, and defining molecular boundaries.With its classroom-tested pedagogical approach, Equilibria and Kinetics of Biological Macromolecules is recommended as a graduate-level textbook for biophysics courses and as a reference for researchers who want to strengthen their understanding of macromolecular behavior.
Equilibrium Compound Nucleus Post-Fission Theory
by Ye Tian Qing-Biao ShenThis book proposes and develops the equilibrium compound nucleus post-fission theory, a powerful tool for studying the fission process and making numerical calculations of post-fission nuclear data. It begins with a detailed historical background on fission theory and covers fundamental concepts, such as the Bohr-Wheeler formula and time dependent nuclear density functional theory.The authors explain the kinematics of heavy-ion collisions and develop a heavy-ion spherical optical model. They also present the theoretical methods for calculating the yield, kinetic energy distribution, and angular distribution of fission fragments in the initial state of fission. In addition, readers are provided with the method for calculating the prompt neutron and prompt gamma-ray data as well as the proportion of the isomeric state nucleus and independent yield from the initial yield of the fission fragments. Using the nuclear decay data of the fission products, a method for calculating the cumulative yield and decay heat of the fission fragments is also given. A fission delayed neutron simplification model is proposed and the theoretical method for calculating the total contribution of three fission channels to post-fission nuclear data is provided.This book concludes with a step-by-step guide on numerical calculations for post-fission nuclear data and a Fortran program for optimizing the best theoretical model parameters. It is ideal for both junior and senior researchers in nuclear physics, as well as graduate students who are interested learning about the subject. Given the current interest in post-fission and the tremendous experimental and theoretical efforts in studying it, this book serves as a timely and comprehensive resource for the nuclear physics community.
Equilibrium Molecular Structures: From Spectroscopy to Quantum Chemistry
by Jean Demaison James E. Boggs Attila G. CsászárMolecular structure is the most basic information about a substance, determining most of its properties. Determination of accurate structures is hampered in that every method applies its own definition of "structure" and thus results from different sources can yield significantly different results. Sophisticated protocols exist to account for these
Equilibrium Statistical Mechanics
by E. Atlee JacksonIdeal as an elementary introduction to equilibrium statistical mechanics, this volume covers both classical and quantum methodology for open and closed systems. Introductory chapters familiarize readers with probability and microscopic models of systems, while additional chapters describe the general derivation of the fundamental statistical mechanics relationships. The final chapter contains 16 sections, each dealing with a different application, ordered according to complexity, from classical through degenerate quantum statistical mechanics. Key features include an elementary introduction to probability, distribution, functions, and uncertainty prior to a discussion of statistical mechanics; a review of the concept and significance of energy, together with a discussion of various models of physical systems. A series of appendixes contains helpful information on Gaussian integrals, the error function, the entropy constant, solutions to problems, and other subjects.A background in integral calculus is assumed, but because material is presented at a reasonable level of complexity, even readers not familiar with quantum mechanics can make use of at least two-thirds of this book. Index. 5 Appendixes. Problems at ends of chapters. Over 100 text figures.
Equilibrium Statistical Mechanics of Lattice Models
by David A. LavisMost interesting and difficult problems in equilibrium statistical mechanics concern models which exhibit phase transitions. For graduate students and more experienced researchers this book provides an invaluable reference source of approximate and exact solutions for a comprehensive range of such models. Part I contains background material on classical thermodynamics and statistical mechanics, together with a classification and survey of lattice models. The geometry of phase transitions is described and scaling theory is used to introduce critical exponents and scaling laws. An introduction is given to finite-size scaling, conformal invariance and Schramm--Loewner evolution. Part II contains accounts of classical mean-field methods. The parallels between Landau expansions and catastrophe theory are discussed and Ginzburg--Landau theory is introduced. The extension of mean-field theory to higher-orders is explored using the Kikuchi--Hijmans--De Boer hierarchy of approximations. In Part III the use of algebraic, transformation and decoration methods to obtain exact system information is considered. This is followed by an account of the use of transfer matrices for the location of incipient phase transitions in one-dimensionally infinite models and for exact solutions for two-dimensionally infinite systems. The latter is applied to a general analysis of eight-vertex models yielding as special cases the two-dimensional Ising model and the six-vertex model. The treatment of exact results ends with a discussion of dimer models. In Part IV series methods and real-space renormalization group transformations are discussed. The use of the De Neef--Enting finite-lattice method is described in detail and applied to the derivation of series for a number of model systems, in particular for the Potts model. The use of Pad\'e, differential and algebraic approximants to locate and analyze second- and first-order transitions is described. The realization of the ideas of scaling theory by the renormalization group is presented together with treatments of various approximation schemes including phenomenological renormalization. Part V of the book contains a collection of mathematical appendices intended to minimise the need to refer to other mathematical sources.
Equilibrium Statistical Physics: Phases, Phase Transitions, and Topological Phases
by Marc Baus Carlos F. TejeroThis is a textbook which gradually introduces the student to the statistical mechanical study of the different phases of matter and to the phase transitions between them. Throughout, only simple models of both ordinary and soft matter are used but these are studied in full detail. The subject is developed in a pedagogical manner, starting from the basics, going from the simple ideal systems to the interacting systems, and ending with the more modern topics. The textbook provides the student with a complete overview, intentionally at an introductory level, of the theory of phase transitions. All equations and deductions are included.
Equilibrium Structure of Free Molecules: Theory, Experiment, and Data Analysis (Lecture Notes in Chemistry #111)
by Natalja Vogt Jean DemaisonThis book examines around 400 of the most striking examples of structural studies of free molecules—selected and analyzed by virtue of the unique molecular complexity and novelty of the experimental techniques used. The properties of chemical, pharmaceutical, and biological compounds depend mainly on their molecular structure, the determination of which is of fundamental interest. Featuring high-quality structural data determined using modern techniques in electron diffraction and high-resolution spectroscopy, the book is an indispensable resource for graduate students and professional scientists specializing in structural chemistry and other relevant fields.
Equilibrium Thermodynamics
by Mário J. OliveiraThis textbook provides an exposition of equilibrium thermodynamics and its applications to several areas of physics with particular attention to phase transitions and critical phenomena. The applications include several areas of condensed matter physics and include also a chapter on thermochemistry. Phase transitions and critical phenomena are treated according to the modern development of the field, based on the ideas of universality and on the Widom scaling theory. For each topic, a mean-field or Landau theory is presented to describe qualitatively the phase transitions. These theories include the van der Waals theory of the liquid-vapor transition, the Hildebrand-Heitler theory of regular mixtures, the Griffiths-Landau theory for multicritical points in multicomponent systems, the Bragg-Williams theory of order-disorder in alloys, the Weiss theory of ferromagnetism, the Néel theory of antiferromagnetism, the Devonshire theory for ferroelectrics and Landau-de Gennes theory of liquid crystals. This textbook is intended for students in physics and chemistry and provides a unique combination of thorough theoretical explanation and presentation of applications in both areas. Chapter summaries, highlighted essentials and problems with solutions enable a self sustained approach and deepen the knowledge.
Equilibrium Thermodynamics
by Mário J. de OliveiraThis textbook provides an exposition of equilibrium thermodynamics and its applications to several areas of physics with particular attention to phase transitions and critical phenomena. The applications include several areas of condensed matter physics and include also a chapter on thermochemistry. Phase transitions and critical phenomena are treated according to the modern development of the field, based on the ideas of universality and on the Widom scaling theory. For each topic, a mean-field or Landau theory is presented to describe qualitatively the phase transitions. These theories include the van der Waals theory of the liquid-vapor transition, the Hildebrand-Heitler theory of regular mixtures, the Griffiths-Landau theory for multicritical points in multicomponent systems, the Bragg-Williams theory of order-disorder in alloys, the Weiss theory of ferromagnetism, the N#65533;el theory of antiferromagnetism, the Devonshire theory for ferroelectrics and Landau-de Gennes theory of liquid crystals. This new edition presents expanded sections on phase transitions, liquid crystals and magnetic systems, for all problems detailed solutions are provided. It is intended for students in physics and chemistry and provides a unique combination of thorough theoretical explanation and presentation of applications in both areas. Chapter summaries, highlighted essentials and problems with solutions enable a self sustained approach and deepen the knowledge. It is intended for students in physics and chemistry and provides a unique combination of thorough theoretical explanation and presentation of applications in both areas. Chapter summaries, highlighted essentials and problems with solutions enable a self sustained approach and deepen the knowledge.
Equilibrium and Nonequilibrium Aspects of Phase Transitions in Quantum Physics (Springer Theses)
by Ricardo PueblaIn this book, the equilibrium and nonequilibrium properties of continuous phase transitions are studied in various systems, with a special emphasis on understanding how well-established universal traits at equilibrium may be extended into the dynamic realm, going beyond the paradigmatic Kibble–Zurek mechanism of defect formation. This book reports on the existence of a quantum phase transition in a system comprising just a single spin and a bosonic mode (the quantum Rabi model). Though critical phenomena are inherent to many-body physics, the author demonstrates that this small and ostensibly simple system allows us to explore the rich phenomenology of phase transitions, both in- and out-of-equilibrium. Moreover, the universal traits of this quantum phase transition may be realized in a single trapped-ion experiment, thus avoiding the need to scale up the number of constituents. In this system, the phase transition takes place in a suitable limit of system parameters rather than in the conventional thermodynamic limit – a novel notion that the author and his collaborators have dubbed the finite-component system phase transition. As such, the results gathered in this book will open promising new avenues in our understanding and exploration of quantum critical phenomena.
Equine Behaviour in Practice: Understanding Horses and Treating Behaviour Problems
by Debbie BusbyCombining an in-depth exploration of equine behaviour with clinical practice from a new progressive perspective, Equine Behaviour in Practice: Understanding Horses and Treating Behaviour Problems focuses not just on the horse’s behaviour but also on the behaviour of the human interacting with the horse. Acclaimed Clinical Equine Behaviourist Debbie Busby delivers evidence-based knowledge that will equip readers with the understanding and skills to become effective equine behaviour consultants. Supported by considered discussion of how and why horses sometimes struggle to cope, the book comprehensively explains how to consult on and treat a range of equine behaviour problems. Rather than providing a formulaic "here’s the problem; here’s how to fix it", Busby encourages readers to develop a critical biopsychosocial evaluation based on an understanding of how horses evolved, their ethological and physiological adaptations, how they learn, and how their welfare and wellbeing can be assessed. KEY FEATURES: Part 1 explains theories of equine evolution and the thin veneer of domestication Part 2 describes psychological and physiological theories of how horses learn, and how this can be applied in training and behaviour modification Part 3 illustrates this with reference to relevant legislation and widely used animal welfare models, as well as assessments of abnormal and stereotypic behaviour and practical aspects of measuring welfare Part 4 turns to the theory and practice of behaviour consulting, in three chapters divided into elements of behavioural assessment and treatment planning Part 5 examines the use of psychopharmaceuticals in behaviour therapy, discussing the roles of the behaviour consultant and the referring veterinary surgeon Bridging the gap between science and practice, this book is a must-read for equine behaviour and veterinary students, equine behaviour consultants and practitioners, horse trainers, interested leisure riders and competition riders. It will empower equine professionals to combine behavioural and welfare knowledge with counselling and coaching skills to support horse owners in a mutual flourishing, enriching the lives of both species.
Equine Genomics
by Bhanu P. ChowdharyAnalysis of the equine genome began just over a decade ago, culminating in the recent complete sequencing of the horse genome. The availability of the equine whole genome sequence represents the successful completion of an important era of equine genome analysis, and the beginning of a new era where the sequence information will catalyze the development of new tools and resources that will permit study of a range of traits that are economically important and are significant to equine health and welfare.Equine Genomics provides a timely comprehensive overview of equine genomic research. Chapters detail key accomplishments and the current state of research, as well as looking forward to possible applications of genomic technologies to horse breeding, health, and welfare. Equine Genomics delivers a global overview of the topic and is seamlessly edited by a leading equine genomics researcher. Equine Genomics is an indispensible source of information for anyone with an interest in this increasingly important field of study, including equine genomic researchers, clinicians, animal science professionals and equine field veterinarians.
Equine Reproduction
by Edward L. Squires Wendy E. Vaala Angus O. Mckinnon Dickson D. VarnerNow in a much-anticipated two-volume new edition, this gold-standard reference stands as the most comprehensive and authoritative text on equine reproduction. Serving theriogenologists, practitioners and breeders worldwide as a one-stop resource for the reproductive assessment and management of equine patients, Equine Reproduction, Second Edition provides detailed information on examination techniques, breeding procedures, pregnancy diagnosis and management, reproductive tract diseases and surgery, and foaling. A companion CD offers hundreds of images from the book in color. For the Second Edition, the stallion, mare and foal sections have been thoroughly updated and revised to include the latest information on every subject. New topics include discussion of nutritional and behavioral factors in the broodmare and stallion, parentage testing, fetal sexing and the health and management of older foals, weanlings and yearlings. Additionally, this outstanding Second Edition features a new section on assisted reproductive techniques, including detailed information on artificial insemination, in-vitro fertilization, embryo transfer and technology.
Equine Science (3rd edition)
by Rick ParkerHorses hold a special place in North America's history and culture. As America evolved, horses contributed to the economy by providing power for transportation and industry. Today horses still contribute to the economy but in a much different way. According to a study commissioned by the American Horse Council Foundation, the 9.2 million horses in the United States contribute $39 billion annually in direct economic impact and support 1.4 million jobs on a full-time basis. When indirect spending is included, the horse industry's economic impact reaches $102 billion annually. The overall economic impact of horses comes from racing, recreation, sports, rodeos, farm work, pleasure riding, and competitions. While millions of people participate in the horse industry as spectators, almost 5 million Americans are involved in the industry as horse owners, service providers, employees, and volunteers. Horses are found in every state, and 45 states have at least 20,000 horses. The horse industry is vital and growing. With this vitality and growth comes the need for information about horses, so the numbers of horse-related educational programs, books, pamphlets, videos, and Internet sites are increasing rapidly.