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Experimental and Applied Immunotherapy

Immunotherapy is now recognized as an essential component of treatment for a wide variety of cancers. It is an interdisciplinary field that is critically dependent upon an improved understanding of a vast network of cross-regulatory cellular populations and a diversity of molecular effectors; it is a leading example of translational medicine with a favorable concept-to-clinical-trial timeframe of just a few years. There are many established immunotherapies already in existence, but there are exciting new cancer immunotherapies just on the horizon, which are likely to be more potent, less toxic and more cost effective than many therapies currently in use. Experimental and Applied Immunotherapy is a state-of-the-art text offering a roadmap leading to the creation of these future cancer-fighting immunotherapies. It includes essays by leading researchers that cover a wide variety of topics including T cell and non-T cell therapy, monoclonal antibody therapy, dendritic cell-based cancer vaccines, mesenchymal stromal cells, negative regulators in cancer immunology and immunotherapy, non-cellular aspects of cancer immunotherapy, the combining of cancer vaccines with conventional therapies, the combining of oncolytic viruses with cancer immunotherapy, transplantation, and more. The field of immunotherapy holds great promise that will soon come to fruition if creative investigators can bridge seemingly disparate disciplines, such as T cell therapy, gene therapy, and transplantation therapy. This text is a vital tool in the building of that bridge.

Experimental and Applied Mechanics, Volume 4

Experimental and Applied Mechanics, Volume 4: Proceedings of the 2012 Annual Conference on Experimental and Applied Mechanics, the fourth volume of seven from the Conference, brings together 54 contributions to this important area of research and engineering. The collection presents early findings and case studies on fundamental and applied aspects of Experimental and Applied Mechanics, including papers on: Fracture & FatigueMicroscale & Microstructural Effects in Fatigue & FractureMaterial ApplicationsComposite Characterization Using Digital Image Correlation TechniquesMulti-Scale Simulation and Testing of CompositesResidual StressInverse Problems/Hybrid MethodsNano-CompositesMicrostructure Material CharacterizationModeling and Uncertainty QuantificationImpact Behavior of Composites

Experimental and Applied Mechanics, Volume 4

Experimental and Applied Mechanics, Volume 4 of the Proceedings of the 2015SEM Annual Conference& Exposition on Experimental and Applied Mechanics, the fourth volume of nine from the Conference, brings together contributions to important areas of research and engineering. The collection presents early findings and case studies on a wide range of topics, including: Advanced Methods for Frontier Applications, Non-Homogeneous Parameters Identification, Teaching Experimental Mechanics in the 21st Century, Material Characterization and Testing, Mechanics of Interfaces Novel Applications of Experimental Mechanics

Experimental and Applied Mechanics, Volume 4

Experimental and Applied Mechanics, Volume 4 of the Proceedings of the 2016 SEM Annual Conference & Exposition on Experimental and Applied Mechanics, the fourth volume of ten from the Conference, brings together contributions to important areas of research and engineering. The collection presents early findings and case studies on a wide range of topics, including: Hybrid Experimental & Computational Techniques Advanced Experimental Mechanics Methods Integration of Models & Experiments Soft Materials Education & Research in Progress Applications

Experimental and Applied Mechanics, Volume 6

Experimental and Applied Mechanics, Volume 6: Proceedings of the 2014 Annual Conference on Experimental and Applied Mechanics, the sixth volume of eight from the Conference, brings together contributions to important areas of research and engineering The collection presents early findings and case studies on a wide range of topics, including: Advances in Residual Stress Measurement Methods Residual Stress Effects on Material Performance Inverse Problems and Hybrid Techniques Thermoelastic Stress Analysis Infrared Techniques Research in Progress Applications in Experimental Mechanics

Experimental and Clinical Methods in Hepatic Encephalopathy Research (Neuromethods #219)

This volume explores the latest experimental and clinical protocols used to study hepatic encephalopathy (HE). The chapters in this book are organized into three parts, each focusing on different aspects of HE research. Part One covers protocols for diagnosing and monitoring HE in clinical practice. Part Two talks about various animal models and experimental techniques designed to investigate the pathogenesis of HE and evaluate potential treatments. Part Three looks at the underlying mechanisms and pathophysiological processes involved in HE, and presents advanced techniques and strategies for investigating the complex interactions that contribute to HE. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and authoritative, Experimental and Clinical Methods in Hepatic Encephalopathy Research provides researchers and clinicians with a comprehensive guide of both experimental and clinical methods, and the mechanisms underlying the complex condition of HE.

Experimental and Computational Fluid Mechanics

This book collects invited lectures and selected contributions presented at the Enzo Levi and XVIII Annual Meeting of the Fluid Dynamic Division of the Mexican Physical Society in 2012. It is intended for fourth-year undergraduate and graduate students, and for scientists in the fields of physics, engineering and chemistry with an interest in Fluid Dynamics from experimental, theoretical and computational points of view. The invited lectures are introductory in nature and avoid the use of complicated mathematics. The other selected contributions are also suitable for fourth-year undergraduate and graduate students. The Fluid Dynamics applications include oceanography, multiphase flows, convection, diffusion, heat transfer, rheology, granular materials, viscous flows, porous media flows and astrophysics. The material presented in the book includes recent advances in experimental and computational fluid dynamics and is well-suited to both teaching and research.

Experimental and Kinetic Modeling Study of Cyclohexane and Its Mono-alkylated Derivatives Combustion (Springer Theses)

This thesis investigates the combustion chemistry of cyclohexane, methylcyclohexane, and ethylcyclohexane on the basis of state-of-the-art synchrotron radiation photoionization mass spectrometry experiments, quantum chemistry calculations, and extensive kinetic modeling. It explores the initial decomposition mechanism and distribution of the intermediates, proposes a novel formation mechanism of aromatics, and develops a detailed kinetic model to predict the three cycloalkanes' combustion properties under a wide range of conditions. Accordingly, the thesis provides an essential basis for studying much more complex cycloalkanes in transport fuels and has applications in engine and fuel design, as well as emission control.

Experimental and Numerical Investigation of Advanced Materials and Structures

The idea of this monograph is to present the latest results related to experimental and numerical investigations of advanced materials and structures. The contributions cover the field of mechanical, civil and materials engineering, ranging from new modelling and simulation techniques, advanced analysis techniques, optimization of structures and materials and constitutive modelling. Well known experts present their research on damage and fracture of material and structures, materials modelling and evaluation up to image processing and visualization for advanced analyses and evaluation.

Experimental And Quasi-experimental Designs For Generalized Causal Inference

This long awaited successor of the original Cook/Campbell Quasi-Experimentation: Design and Analysis Issues for Field Settings represents updates in the field over the last two decades. The book covers four major topics in field experimentation.

Experimental and Theoretical Advances in Fluid Dynamics

The book is comprised of lectures and selected contributions presented at the Enzo Levi and XVI Annual Meeting of the Fluid Dynamic Division of the Mexican Physical Society in 2010. It is aimed at fourth year undergraduate and graduate students, as well as scientists in the fields of physics, engineering and chemistry with an interest in fluid dynamics from the experimental and theoretical point of view. The lectures are introductory and avoid the use of complicated mathematics. The other selected contributions are also geared to fourth year undergraduate and graduate students. The fluid dynamics applications include multiphase flow, convection, diffusion, heat transfer, rheology, granular material, viscous flow, porous media flow, geophysics and astrophysics. The material contained in the book includes recent advances in experimental and theoretical fluid dynamics and will be of great use to those involved in either teaching and/or research.

Experimental and Theoretical Approaches to Actinide Chemistry

A review of contemporary actinide research that focuses on new advances in experiment and theory, and the interplay between these two realms Experimental and Theoretical Approaches to Actinide Chemistry offers a comprehensive review of the key aspects of actinide research. Written by noted experts in the field, the text includes information on new advances in experiment and theory and reveals the interplay between these two realms. The authors offer a multidisciplinary and multimodal approach to the nature of actinide chemistry, and explore the interplay between multiple experiments and theory, as well as between basic and applied actinide chemistry. The text covers the basic science used in contemporary studies of the actinide systems, from basic synthesis to state-of-the-art spectroscopic and computational techniques. The authors provide contemporary overviews of each topic area presented and describe the current and anticipated experimental approaches for the field, as well as the current and future computational chemistry and materials techniques. In addition, the authors explore the combination of experiment and theory. This important resource: Provides an essential resource the reviews the key aspects of contemporary actinide research Includes information on new advances in experiment and theory, and the interplay between the two Covers the basic science used in contemporary studies of the actinide systems, from basic synthesis to state-of-the-art spectroscopic and computational techniques Focuses on the interplay between multiple experiments and theory, as well as between basic and applied actinide chemistry Written for academics, students, professionals and researchers, this vital text contains a thorough review of the key aspects of actinide research and explores the most recent advances in experiment and theory.

The Experimental Animal in Biomedical Research: A Survey of Scientific and Ethical Issues for Investigators, Volume I

The Experimental Animal in Biomedical Research provides a concise, useful survey of knowledge regarding laboratory animal care. Volume I addresses researchers who use animals and focuses on how to maximize the welfare of animals used in research.

Experimental Approaches of NMR Spectroscopy

This book describes the advanced developments in methodology and applications of NMR spectroscopy to life science and materials science. Experts who are leaders in the development of new methods and applications of life and material sciences have contributed an exciting range of topics that cover recent advances in structural determination of biological and material molecules, dynamic aspects of biological and material molecules, and development of novel NMR techniques, including resolution and sensitivity enhancement. First, this book particularly emphasizes the experimental details for new researchers to use NMR spectroscopy and pick up the potentials of NMR spectroscopy. Second, the book is designed for those who are involved in either developing the technique or expanding the NMR application fields by applying them to specific samples. Third, the Nuclear Magnetic Resonance Society of Japan has organized this book not only for NMR members of Japan but also for readers worldwide who are interested in using NMR spectroscopy extensively.

Experimental Approaches of NMR Spectroscopy I: Methodology

This book describes advanced developments in the methodology and applications of NMR spectroscopy in the life science and materials science fields. In this book, new experimental methods and new NMR research fields are presented with chapters on the structure of membrane proteins, in cell NMR, and Electro-Mechano-Optical NMR is added. Experts in the field have contributed an exciting range of topics that cover recent advances in high-pressure NMR, selectively isotope-aided NMR, ultrafast MAS NMR, dynamic nuclear polarization (DNP) NMR, optical and microwave irradiation NMR. This book emphasizes the experimental details for new researchers to use NMR spectroscopy and pick up the potentials of this technique. It is also designed for those who are involved in either developing the technique or expanding the NMR application field by applying them to specific samples. The Nuclear Magnetic Resonance Society of Japan has organized this book not only for NMR users of Japan but also for readers worldwide who are interested in using NMR spectroscopy extensively.

Experimental Approaches of NMR Spectroscopy II: Application to Life Science and Materials Science

This book describes advanced developments in the methodology and applications of NMR spectroscopy in the life science and materials science fields. In this book, experts in the NMR field have contributed an exciting range of topics that cover recent advances in structural and dynamic aspects of material molecules such as silk fibrils, polymer materials and organic light-emitting diodes, and biological molecules such as natural products, glycoproteins, and ribonucleic acid (RNA). This book emphasizes the experimental details for new researchers to use NMR spectroscopy and pick up the potential of this technique. It is also designed for those who are involved in either developing the technique or expanding the NMR application field by applying them to specific samples. The Nuclear Magnetic Resonance Society of Japan has organized this book not only for NMR members of Japan but also for readers worldwide who are interested in using NMR spectroscopy extensively.

Experimental Approaches to Understanding Fossil Organisms

Paleontologists and geologists struggle with research questions often complicated by the loss or even absence of key paleobiological and paleoenvironmental information. Insight into this missing data can be gained through direct exploration of analogous living organisms and modern environments. Creative, experimental and interdisciplinary treatments of such ancient-Earth analogs form the basis of Lessons from the Living. This volume unites a diverse range of expert paleontologists, neontologists and geologists presenting case studies that cover a spectrum of topics, including functional morphology, taphonomy, environments and organism-substrate interactions.

Experimental Design: With Applications In Management, Engineering And The Sciences

CLICHE: nounEtymology: French, literally, printer's stereotype, from past participle of clicher, to stereotype, of imitative originDate: 18921: a trite phrase or expression; also: the idea expressed by it2: a hackneyed theme, characterization, or situation3: something that has become overly familiar or commonplaceIn the words of Stephen Fry, It is a cliche that most cliches are true, but then like most cliches, that cliche is untrue. Cliches are like rationalizations: try going a week without using one. It can't be done They are the hobgoblin of little minds. For most of us, once you begin to take notice, they are fingernails on a chalkboard. From Shakespeare to Shakira; in music, on television, at the movies; in the boardroom, on a conference call, online or in person, cliches have taken over the world. While some nitwits might say they're just misunderstood, they didn't start out that way. There was a time when they were new and vibrant, clever and pithy. Now they're just predictable a vapid collection of much-too-familiar descriptions or metaphors that often replace smart conversation, speech, or writing. This book is a collection of the most overused phrases of all time. Hopefully, it'll make you laugh. Hopefully, it'll make them think. And at the end of the day, if the early bird catches the worm and the slow and steady win the race . . . Please . . . kill . . . me . . . now.

Experimental Design and Data Analysis for Biologists

An essential textbook for any student or researcher in biology needing to design experiments, sample programs or analyse the resulting data. The text begins with a revision of estimation and hypothesis testing methods, covering both classical and Bayesian philosophies, before advancing to the analysis of linear and generalized linear models. Topics covered include linear and logistic regression, simple and complex ANOVA models (for factorial, nested, block, split-plot and repeated measures and covariance designs), and log-linear models. Multivariate techniques, including classification and ordination, are then introduced. Special emphasis is placed on checking assumptions, exploratory data analysis and presentation of results. The main analyses are illustrated with many examples from published papers and there is an extensive reference list to both the statistical and biological literature. The book is supported by a web-site that provides all data sets, questions for each chapter and links to software.

Experimental Design and Data Analysis for Biologists

Experimental Design and Process Optimization

Experimental Design and Process Optimization delves deep into the design of experiments (DOE). The book includes Central Composite Rotational Design (CCRD), fractional factorial, and Plackett and Burman designs as a means to solve challenges in research and development as well as a tool for the improvement of the processes already implemented. Appr

Experimental Design and Scientific Data Analysis (Science for Conservators)

Experimental Design and Scientific Data Analysis provides accessible information about the research process from start to finish as applied to conservation to enable readers to successfully plan and carry out research and share findings effectively with others.The book is divided into two parts, starting with experimental design in Part 1 and then considering data analysis in Part 2. Part 1 takes the reader through the process of designing and planning experiments, from the initial design of aims and objectives to ethical testing, and includes a range of examples to demonstrate how these ideas apply to a range of specialisms and materials. Part 2 focuses on what to do with data once it has been collected, including choosing the right statistical test, different methods of presenting information, and communicating your findings clearly to your chosen audience. Questions at the end of each chapter are designed to help readers check and consolidate their knowledge of the different topics.Experimental Design and Scientific Data Analysis is suitable for students, emerging professionals, and experienced conservators at different stages of their careers, and is particularly suitable for those without a scientific background.

Experimental Design for the Life Sciences, Third Edition

Experimental Design for the Life Sciences, Third Edition, demonstrates how good experimental design relies on clear thinking and biological understanding, not on mathematical or statistical complexity.

Experimental Design in Biotechnology (Statistics: A Series Of Textbooks And Monographs #105)

This book provides the first time user of statistics with an understanding of how and why statistical experimental design and analysis can be an effective problem solving tool. It presents experimental designs which are useful for small screening and response surface experiments.

Experimental Design Research

This book presents a new, multidisciplinary perspective on and paradigm for integrative experimental design research. It addresses various perspectives on methods, analysis and overall research approach, and how they can be synthesized to advance understanding of design. It explores the foundations of experimental approaches and their utility in this domain, and brings together analytical approaches to promote an integrated understanding. The book also investigates where these approaches lead to and how they link design research more fully with other disciplines (e. g. psychology, cognition, sociology, computer science, management). Above all, the book emphasizes the integrative nature of design research in terms of the methods, theories, and units of study - from the individual to the organizational level. Although this approach offers many advantages, it has inherently led to a situation in current research practice where methods are diverging and integration between individual, team and organizational understanding is becoming increasingly tenuous, calling for a multidisciplinary and transdiscipinary perspective. Experimental design research thus offers a powerful tool and platform for resolving these challenges. Providing an invaluable resource for the design research community, this book paves the way for the next generation of researchers in the field by bridging methods and methodology. As such, it will especially benefit postgraduate students and researchers in design research, as well as engineering designers.