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GPCRs as Therapeutic Targets

A thorough discussion of the structure, pharmacology, function, and role of G protein-coupled receptors In GPCRs as Therapeutic Agents, distinguished researcher Dr. Annette Gilchrist delivers an authoritative and in-depth compendium of a vibrant and active area of academic and industrial drug discovery. The book serves as an important reference for new and experienced researchers studying G protein-coupled receptors and discusses the molecular pharmacology of this important target class. It also includes up-to-date material on GPCR structures and structure-based drug design. The book explores the role of GPCRs in the treatment of disease and novel approaches to their study. In addition to providing information on the structure, pharmacology, and function of GPCRs, it discusses their role in disease states, and advances new methods for measuring GPCR activity in an accessible and engaging way. The book includes: A thorough introduction to the molecular pharmacology of G protein-coupled receptors, including up-to-date material on GPCR structures and structure-based drug design In-depth discussions of the evolving pharmacology for GPCRs, intracellular trafficking, and subcellular GPCR signaling Comprehensive explorations of allosteric modulation, receptor dimerization, deorphanization, and ubiquitination Fulsome treatments of the role played by GPCRs in the treatments of cancer, substance use disorders, cerebrovascular diseases, and metabolic diseasesPerfect for researchers in biochemistry, cell biology, and pharmacology, GPCRs as Therapeutic Agents will also earn a place in the libraries of professionals working in medicinal chemistry, structural biology, and clinical pharmacology.

GPR Remote Sensing in Archaeology

GPR Remote Sensing in Archaeology provides a complete description of the processes needed to take raw GPR data all the way to the construction of subsurface images. The book provides an introduction to the "theory" of GPR by using a simulator that shows how radar profiles across simple model structures look and provides many examples so that the complexity of radar signatures can be understood. It continues with a review of the necessary radargram signal processes needed along with examples. The most comprehensive methodology to construct subsurface images from either coarsely spaced data using interpolation or from dense data from multi-channel equipment and 3D volume generation is presented, advanced imaging solutions such as overlay analysis are introduced, and numerous worldwide site case histories are shown. The authors present their studies in a way that most technical and non-technical users of the equipment will find essentials for implementing in their own subsurface investigations.

GPU Solutions to Multi-scale Problems in Science and Engineering

This book covers the new topic of GPU computing with many applications involved, taken from diverse fields such as networking, seismology, fluid mechanics, nano-materials, data-mining , earthquakes ,mantle convection, visualization. It will show the public why GPU computing is important and easy to use. It will offer a reason why GPU computing is useful and how to implement codes in an everyday situation.

Grab 'n' Go Astronomy

Like everyone else, most amateur astronomers live busy lives. After a long day or work or looking after young children, the last thing you want as an observer is to have to lug out a large telescope and spend an hour getting it ready before it can be used. Maybe you are going on vacation somewhere in the countryside where there are sure to be dark skies, but you don't necessarily want astronomy to dominate the trip. Or suppose you are not quite committed to owning a large telescope, but curious enough to see what a smaller, portable setup can accomplish. These are times when a small "grab 'n' go" telescope, or even a pair of binoculars, is the ideal instrument. And this book can guide you in choosing and best utilizing that equipment. What makes a telescope fall into the "grab 'n' go" category? That's easy - speed of setting up, ease of use, and above all, portability. In Part I of this book, we survey the various types of equipment, including accessories and mounts, that are available, and what it is best for what kind of viewing. Part II is about using your grab 'n' go telescope to visit a wealth and wide variety of objects. There are chapters on solar, lunar and planetary observing, as well as descriptions of many deep sky objects, including double and variable stars, planetary, emission and reflection nebulae, open and globular clusters and distant galaxies. This ambitious text is dedicated to those who love to or - because of their limited time - must observe the sky at a moment's notice, whether from the comfort of a backyard or while on business or vacation far from home. Everything you need to know is here. So get started!.

Grace Hopper: Navy Admiral and Computer Pioneer

Traces the life of the scientist who, as well as having a distinguished career in the Navy, was a pioneer contributor to computer science and is known as the grandmother of the computer age.

Grace in All Simplicity: Beauty, Truth, and Wonders on the Path to the Higgs Boson and New Laws of Nature

An enthralling and accessible account of humanity&’s quest to make sense of our physical world, told through interwoven tales of inspiration, tragedy, and triumph.How do the remarkable recent discoveries of the Higgs boson, dark matter, and dark energy connect with the equally revolutionary discoveries in centuries past? In Grace in All Simplicity, readers will delight in Cahn and Quigg's engaging prose and see how the infinite and the infinitesimal are joined. Today, physicists and astronomers are exploring distances from a billionth of a billionth of the human scale to the entire cosmos, and contemplating time intervals that range from less than a trillionth of a trillionth of a second out to far longer than the age of the universe. Leaving home in this metaphorical way requires devising new instruments that spectacularly expand our senses and conceiving original ways of thinking that expand our minds. This is at once an act of audacity and an exercise in humility. Grace in All Simplicity narrates the saga of how we have prospected for some of Nature&’s most tightly held secrets, the basic constituents of matter and the fundamental forces that rule them. Our current understanding of the world (and universe) we inhabit is the result of curiosity, diligence, and daring, of abstraction and synthesis, and of an abiding faith in the value of exploration. In these pages we will meet scientists of both past and present. These men and women are professional scientists and amateurs, the eccentric and the conventional, performers and introverts. Scientists themselves, Cahn and Quigg convey their infectious joy as they search for new laws of nature. Join the adventure as scientists ascend mountain tops and descend into caverns deep underground, travel to the coldest places on Earth, and voyage back in time to near the birth of the Universe. Visit today&’s great laboratories and the astounding instruments they house. Grace in All Simplicity is a thrilling voyage filled with improbable discoveries and the extraordinary community of people who make them. Together, we will travel the path to the Higgs boson, weigh the evidence for subliminal dark matter, and learn what makes scientists invoke a mysterious agent named "dark energy." We will behold the emergence of a compelling picture of matter and forces, simple in its structure, graceful in the interplay of its parts, but still tantalizingly incomplete.

The Grace of Dogs: A Boy, a Black Lab, and a Father's Search for the Canine Soul

In the bestselling tradition of Inside of a Dog and Marley & Me, a smart, illuminating, and entertaining read on why the dog-human relationship is unique--and possibly even "spiritual." Dr. Andrew Root's search for the canine soul began the day his eight-year-old son led the family in a moving Christian ritual at the burial service for Kirby, their beloved black lab. In the coming weeks, Root found himself wondering: What was this thing we'd experienced with this animal? Why did the loss hurt so poignantly? Why did his son's act seem so right in its sacramental feel? In The Grace of Dogs, Root draws on biology, history, theology, cognitive ethology (the study of animal minds), and paleontology to trace how in our mutual evolution, humans and dogs have so often helped each other to become more fully ourselves. Root explores questions like: Do dogs have souls? Is it accurate to say that dogs "love" us? What do psychology and physiology say about why we react to dogs in the way that we do? The Grace of Dogs paints a vivid picture of how, beyond sentimentality, the dog-human connection can legitimately be described as "spiritual"--as existing not for the sake of gain, but for the unselfish desire to be with and for the other, and to remind us that we are persons worthy of love and able to share love. In this book for any parent whose kids have asked if they'll see Fido in Heaven, or who has looked their beloved dog in the face and wondered what's going on in there, Dr. Root delivers an illuminating and heartfelt read that will change how we understand man's best friend.

Grade 3 Science Resources

NIMAC-sourced textbook

Grade 4 Science Resources

NIMAC-sourced textbook

Grade 5 Science Resources

NIMAC-sourced textbook

Grade 6 Interactive Science (Indiana)

Science textbook

Gradient Expectations: Structure, Origins, and Synthesis of Predictive Neural Networks

An insightful investigation into the mechanisms underlying the predictive functions of neural networks—and their ability to chart a new path for AI.Prediction is a cognitive advantage like few others, inherently linked to our ability to survive and thrive. Our brains are awash in signals that embody prediction. Can we extend this capability more explicitly into synthetic neural networks to improve the function of AI and enhance its place in our world? Gradient Expectations is a bold effort by Keith L. Downing to map the origins and anatomy of natural and artificial neural networks to explore how, when designed as predictive modules, their components might serve as the basis for the simulated evolution of advanced neural network systems.Downing delves into the known neural architecture of the mammalian brain to illuminate the structure of predictive networks and determine more precisely how the ability to predict might have evolved from more primitive neural circuits. He then surveys past and present computational neural models that leverage predictive mechanisms with biological plausibility, identifying elements, such as gradients, that natural and artificial networks share. Behind well-founded predictions lie gradients, Downing finds, but of a different scope than those that belong to today&’s deep learning. Digging into the connections between predictions and gradients, and their manifestation in the brain and neural networks, is one compelling example of how Downing enriches both our understanding of such relationships and their role in strengthening AI tools. Synthesizing critical research in neuroscience, cognitive science, and connectionism, Gradient Expectations offers unique depth and breadth of perspective on predictive neural-network models, including a grasp of predictive neural circuits that enables the integration of computational models of prediction with evolutionary algorithms.

Gradient HPLC for Practitioners: RP, LC-MS, Ion Analytics, Biochromatography, SFC, HILIC

Gradient Microstructure in Laser Shock Peened Materials: Fundamentals and Applications (Springer Series in Materials Science #314)

This book introduces the fundamentals and principles of laser shock peening (LSP) for aeronautical materials. It focuses on the innovation in both theory and method related to LSP-induced gradient structures in titanium alloys and Ni-based alloys which have been commonly used in aircraft industries. The main contents of the book include: the characteristics of laser shock wave, the formation mechanism of gradient structures and the strengthening-toughing mechanism by gradient structures. The research has accumulated a large amount of experimental data, which has proven the significant effectiveness of LSP on the improvement of the fatigue performance of metal parts, and related findings have been successfully applied in aerospace field. This book could be used by the researchers who work in the field of LSP, mechanical strength, machine manufacturing and surface engineering, as well as who major in laser shock wave and materials science.

A Graduate Course in NMR Spectroscopy

This textbook is designed for graduate students to introduce the basic concepts of Nuclear Magnetic Resonance spectroscopy (NMR), spectral analysis and modern developments such as multidimensional NMR, in reasonable detail and rigor. The book is self-contained, so, a unique textbook in that sense with end of chapter exercises included supported by a solution manual. Some of the advanced topics are included as Appendices for quick reference. Students of chemistry who have some exposure to mathematics and physics will benefit from this book and it will prepare them to pursue research in different branches of Chemistry or Biophysics or Structural Biology.​

Graduate Programs in Engineering & Applied Sciences 2011

Peterson's Graduate Programs in Engineering & Applied Sciences contains a wealth of information on colleges and universities that offer graduate degrees in the fields of Aerospace/Aeronautical Engineering; Agricultural Engineering & Bioengineering; Architectural Engineering, Biomedical Engineering & Biotechnology; Chemical Engineering; Civil & Environmental Engineering; Computer Science & Information Technology; Electrical & Computer Engineering; Energy & Power engineering; Engineering Design; Engineering Physics; Geological, Mineral/Mining, and Petroleum Engineering; Industrial Engineering; Management of Engineering & Technology; Materials Sciences & Engineering; Mechanical Engineering & Mechanics; Ocean Engineering; Paper & Textile Engineering; and Telecommunications. <P><P> Up-to-date data, collected through Peterson's Annual Survey of Graduate and Professional Institutions, provides valuable information on degree offerings, professional accreditation, jointly offered degrees, part-time and evening/weekend programs, post-baccalaureate distance degrees, faculty, students, degree requirements, entrance requirements, expenses, financial support, faculty research, and unit head and application contact information. <P> As an added bonus, readers will find a helpful "See Close-Up" link to in-depth program descriptions written by some of these institutions. These Close-Ups offer detailed information about the specific program or department, faculty members and their research, and links to the program Web site.<P> In addition, there are valuable articles on financial assistance and support at the graduate level and the graduate admissions process, with special advice for international and minority students. Another article discusses important facts about accreditation and provides a current list of accrediting agencies.

Graduate Programs in Engineering & Applied Sciences 2013

Peterson's Graduate Programs in Engineering & Applied Sciences 2013 contains comprehensive profiles of more than 3,850 graduate programs in 77 disciplines, including aerospace/aeronautical engineering, agricultural engineering & bioengineering, chemical engineering, civil and environmental engineering, computer science and information technology, electrical and computer engineering, industrial engineering, telecommunications, and more. <P><P> Up-to-date data, collected through Peterson's Annual Survey of Graduate and Professional Institutions, provides valuable information on degree offerings, professional accreditation, jointly offered degrees, part-time and evening/weekend programs, post-baccalaureate distance degrees, faculty, students, requirements, expenses, financial support, faculty research, and unit head and application contact information. <P>Two-page in-depth descriptions provide information about specific graduate programs, schools, or departments, faculty members and their research, and more.<P> There are also valuable articles on financial assistance, the graduate admissions process, advice for international and minority students, and facts about accreditation, with a current list of accrediting agencies.

The Grafter's Handbook

R. J. Garner'sThe Grafter's Handbookis the classic reference book and revered encyclopedia (and the only one of its kind) on plant propagation by grafting, and has been favored by orchardists and gardeners since its first publication in 1947. Now revised and updated for a new generation by respected horticulturist Steve Bradley, the all-time classic is back and better than ever. Everything the dedicated amateur, student, and professional horticulturalist wants to know about grafting is here, clearly written in a concise and straightforward style, the distillation of a lifetime's careful study and research. Chapters include information on compatilibility and cambial contact; rootstocks and their propagation; tools and accessories; methods of grafting; and grafting established trees. Praise for earlier editions:"Mr. Garner almost certainly knows more about vegetative propagation of tree and bush fruit than any man on earth; and what is more to the purpose, he knows how to convey his knowledge clearly in word and line. "--The Guardian"This is not only a masterly textbook illustrated with very clear line drawings and photographs, but also a fascinating anthology of all the ways in which man has found it possible, for one reason or another, to put two varieties of plants together to make one. "--Country Life

Grain Boundaries

Grain boundaries are a main feature of crystalline materials. They play a key role in determining the properties of materials, especially when grain size decreases and even more so with the current improvements of processing tools and methods that allow us to control various elements in a polycrystal. This book presents the theoretical basis of the study of grain boundaries and aims to open up new lines of research in this area. The treatment is light on mathematical approaches while emphasizing practical examples; the issues they raise are discussed with reference to theories. The general approach of the book has two main goals: to lead the reader from the concept of 'ideal' to 'real' grain boundaries; to depart from established knowledge and address the opportunities emerging through "grain boundary engineering", the control of morphological and crystallographic features that affect material properties. The book is divided in three parts: I 'From interganular order to disorder' deals with the concept of the perfect grain boundary, at equilibrium, and questions the maintenance of its crystalline state. II 'From the ideal to the real grain boundary' deals with the concept of the faulted grain boundary. It attempts to reveal the influence of the grain boundary structure on its defects, their formation and their accommodation. III 'From free to constrained grain boundaries' is devoted to grain boundary ensembles starting from the triple junction (the elemental configuration) to real grain boundary networks in polycrystals This part covers a new and topical development in the field. It presents for the first time an avenue for researchers working on macroscopic aspects, to approach the scale of description of grain boundaries. Audience: graduate students, researchers and engineers in Materials Science and all those scientists pursuing grain boundary engineering in order to improve materials performance.

The Grain Brain Whole Life Plan: Boost Brain Performance, Lose Weight, and Achieve Optimal Health

This is the definitive instruction book for the care and feeding of your brain! - Dr Mark Hyman, author The Blood Sugar Solution The official lifestyle companion guide to Dr. David Perlmutter's revolutionary approach to vibrant health, as described in his international bestsellers Grain Brain, The Grain Brain Cookbook, and Brain Maker.With over one million copies sold worldwide, Dr. Perlmutter's books have changed the lives of people across the globe, revealing the devastating truth about the effects of gluten on the brain and teaching us how to reprogram our genetic destiny.Now, Dr. Perlmutter has written the definitive, highly practical lifestyle guide offering readers a step-by-step plan to lower the risk of brain ailments while yielding other benefits, such as weight loss, relief from chronic conditions, and total body rejuvenation.Accessible and science-based, The Grain Brain Whole Life Plan provides readers with actionable information, including all the core nutritional advice they know and love from Grain Brain and Brain Maker, and going far beyond that in a comprehensive, personalised programme.From sleep to stress management, exercise, relationships, and more, The Grain Brain Whole Life Planwill teach you how to live happily and healthily ever after.

The Grain Brain Whole Life Plan: Boost Brain Performance, Lose Weight, and Achieve Optimal Health

The official lifestyle companion guide to Dr. David Perlmutter's revolutionary approach to vibrant health, as described in his international bestsellers Grain Brain, The Grain Brain Cookbook, and Brain Maker. With over one million copies sold worldwide, Dr. Perlmutter's books have changed the lives of people across the globe, revealing the devastating truth about the effects of gluten on the brain and teaching us how to reprogram our genetic destiny. Now, Dr. Perlmutter has written the definitive, highly practical lifestyle guide offering readers a step-by-step plan to lower the risk of brain ailments while yielding other benefits, such as weight loss, relief from chronic conditions, and total body rejuvenation.Accessible and science-based, The Grain Brain Whole Life Plan provides readers with actionable information, including all the core nutritional advice they know and love from Grain Brain and Brain Maker, and going far beyond that in a comprehensive, personalised programme. From sleep to stress management, exercise, relationships, and more, The Grain Brain Whole Life Plan will teach you how to live happily and healthily ever after.(P)2016 Hachette Audio

Grain Legumes

This book is devoted to grain legumes and include eight chapters devoted to the breeding of specific grain legume crops and five general chapters dealing with important topics which are common to most of the species in focus. Soybean is not included in the book as it is commonly considered an oil crop more than a grain legume and is included in the Oil Crops Volume of the Handbook of Plant Breeding. Legume species belong to the Fabaceae family and are characterized by their fruit, usually called pod. Several species of this family were domesticated by humans, such as soybean, common bean, faba bean, pea, chickpea, lentil, peanut, or cowpea. Some of these species are of great relevance as human and animal food. Food legumes are consumed either by their immature pod or their dry seeds, which have a high protein content. Globally, grain legumes are the most relevant source of plant protein, especially in many countries of Africa and Latin America, but there are some constraints in their production, such as a poor adaptation, pest and diseases and unstable yield. Current research trends in Legumes are focused on new methodologies involving genetic and omic studies, as well as new approaches to the genetic improvement of these species, including the relationships with their symbiotic rhizobia.

Grain Marketing: Second Edition

Grain Marketing explores the basic principles and concepts of grain marketing and analyzes the futures and options markets, agricultural policy, grain pricing, and grain marketing structures in the United States, Canada, and the European Community. This text helps students understand the world grain system, trains them to use futures and options, and explains how grain is marketed locally and internationally. The world grain industry affects our daily lives in ways both large and small. It influences what we consume for breakfast, lunch, and dinner and provides at least 40 percent of the world’s food supply. The U.S. and world grain industry affects our income, our investments, and global politics. As world population and therefore global demand for grain grows, the volume handled by the U.S. grain industry will continue to expand, demanding not only improvement in crop yields but also continued efforts to compete in increasingly sophisticated international markets. This newly revised, fully updated text provides a practical, comprehensive overview of grain marketing that is useful to both the upper-level undergraduate studying agricultural marketing and the professional working in the industry. Grain Marketing blends several approaches to the study of commodity marketing, combining the institutional, functional, market structure, and analytical and behavioral systems approach to grain marketing. The book includes basic background information for newcomers to the subject of agricultural marketing as well as more rigorous treatment of advanced subjects. The books overall plan allows the student to follow the movement of the major grains, corn, wheat, and soybeans from farm production to final consumption. Along the way, it provides a detailed description of the worldwide system, encompassing local and multinational corporations, state agencies and boards, national trade and agricultural policies, and the cash and futures markets that serve this industry.

Grain Size Control

Grain Size Control provides an excellent account of the understanding of many matters concerning grains, grain structure, and grain growth in controlling the grain size of polycrystalline metals. It considers the application of the principles of grain growth.

Gram-Positive Pathogens (ASM Books #29)

Gram-positive bacteria, lacking an outer membrane and related secretory systems and having a thick peptidoglycan, have developed novel approaches to pathogenesis by acquiring (among others) a unique family of surface proteins, toxins, enzymes, and prophages. For the new edition, the editors have enhanced this fully researched compendium of Gram-positive bacterial pathogens by including new data generated using genomic sequencing as well as the latest knowledge on Gram-positive structure and mechanisms of antibiotic resistance and theories on the mechanisms of Gram-positive bacterial pathogenicity. This edition emphasizes streptococci, staphylococci, listeria, and spore-forming pathogens, with chapters written by many of the leading researchers in these areas. The chapters systematically dissect these organisms biologically, genetically, and immunologically, in an attempt to understand the strategies used by these bacteria to cause human disease. “This textbook comprises a superb collection of scientific knowledge making it a must-read for any graduate student, medical doctor, or investigator studying these gram-positive bacteria and inspiring future imaginations of biological knowledge.” - William R. Jacobs, Jr., PhD, Professor Microbiology & Immunology, Albert Einstein College of Medicine