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Ampk: Methods And Protocols (Methods In Molecular Biology #1732)
by Benoit Viollet Dietbert NeumannThis volume explores the latest methods used to study AMPK by computational, biochemical, biophysical, cellular, and ex vivo and in vivo approaches. The chapters in this book cover specific topics, such as methods to measure change in cellular energy metabolism and analyze metabolic pathways regulated by AMPK; bioinformatics tools to identify AMPK targets; knockdown of AMPK by CRISPR-Cas9; production and crystallization of full-length human AMP-activated protein kinase; cell-free assays to measure the effects of regulatory ligands on AMPK; use of sensors of AMPK activity; AMPK protein interaction by yeast two-hybrid; the role of AMPK in inflammation and autophagy; analyzing the AMPK function in C. elegans and mammals (with special focus on skeletal muscle, blood vessels, kidneys, pancreatic islets and hypothalamus); and human γ2 AMPK mutations. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Amplifying Informal Science Learning: Rethinking Research, Design, and Engagement
by Judy Diamond Sherman RosenfeldThis collection explores the broad landscape of current and future out-of-school science learning environments. Written by leading experts and innovators in informal science learning, these thoughtful and critical essays examine the changing nature of informal institutions such as science museums, zoos, nature centers, planetariums, aquaria, and botanical gardens and their impact on science education. The book examines the learning opportunities and challenges created by community-based experiences including citizen science, makerspaces, science media, escape rooms, hobby groups, and gaming. Based on current practices, case studies, and research, the book focuses on four cross-cutting themes – inclusivity, digital engagement, community partnerships, and bridging formal and informal learning – to examine how people learn science informally. The book will be of interest to STEM (science, technology, engineering and math) educators – both in and out of school – designers of science and experiential education programs, and those interested in building STEM learning ecosystems in their communities.
Amplitude Modulation of Pulsation Modes in Delta Scuti Stars (Springer Theses)
by Dominic M. BowmanThis outstanding thesis by Dominic Bowman provides a thorough investigation of long-standing questions as to whether amplitude modulation is astrophysical, whether it offers insights into pulsating stars, and whether simple beating of modes with stable amplitudes is unrecognised because of a lack of frequency resolution. In this thesis, the author studied a uniform sample of 983 delta Scuti stars—the most common type of main-sequence heat engine pulsator—that were observed nearly continuously for 4 years at stunning photometric precision of only a few parts per million by the Kepler space mission. With no mission planned to supersede the Kepler 4-year data set, this thesis will stand as the definitive study of these questions for many years. With revolutionary photometric data from the planet-hunting Kepler space mission, asteroseismic studies have been carried out on many hundreds of main-sequence solar-type stars and about 10,000 red giants. It is easy to understand why those stochastically driven stars have highly variable amplitudes. Over much of the rest of the Hertzsprung–Russell (HR) diagram, stellar pulsations are driven by heat mechanisms, which are much more regular than the stochastic driving in solar-like pulsators. Yet for decades, amplitude and frequency modulation of pulsation modes have been observed in almost all types of heat-driven pulsating stars. The author shows that the amplitude and frequency modulation are astrophysical, and he has investigated their implications and prospects to provide new insights into the delta Scuti stars and the many other types of heat-engine pulsators across the HR diagram.
The AMS Weather Book: The Ultimate Guide to America's Weather
by Jack Williams Stephanie Abrams Rick Anthes Jim CantoreAmerica has some of the most varied and dynamic weather in the world. Every year, the Gulf Coast is battered by hurricanes, the Great Plains are ravaged by tornados, the Midwest is pummeled by blizzards, and the temperature in the Southwest reaches a sweltering 120 degrees. Extreme weather can be a matter of life and death, but even when it is pleasant--72 degrees and sunny--weather is still central to the lives of all Americans. Indeed, it's hard to imagine a topic of greater collective interest. Whether we want to know if we should close the storm shutters or just carry an umbrella to work, we turn to forecasts. But few of us really understand the science behind them. All that changes with The AMS Weather Book. The most comprehensive and up-to-date guide to our weather and our atmosphere, it is the ultimate resource for anyone who wants to understand how hurricanes form, why tornados twirl, or even why the sky is cerulean blue. Written by esteemed science journalist and former USA Today weather editor Jack Williams, The AMS Weather Book, copublished with the American Meteorological Society, covers everything from daily weather patterns, air pollution, and global warming to the stories of people coping with severe weather and those who devote their lives to understanding the atmosphere, oceans, and climate. Words alone, of course, are not adequate to explain many meteorological concepts, so The AMS Weather Book is filled with engaging full-color graphics that explain such concepts as why winds blow in a particular direction, how Doppler weather radar works, what happens inside hurricanes, how clouds create wind and snow, and what's really affecting the earth's climate. For Weather Channel junkies, amateur meteorologists, and storm chasers alike, The AMS Weather Book is an invaluable tool for anyone who wants to better understand how weather works and how it affects our lives.
Amsco's Science, Grade 7
by Paul S. Cohen Anthony V. SorrentinoProvides a clear and concise presentation of middle school science concepts.
Amsco's Science Grade 8
by Paul S. Cohen Anthony V. SorrentinoProvides a clear and concise presentation of middle school science concepts. This book discusses current ideas in science taken straight from the headlines.
Amyloid and Amyloidosis
by Gilles Grateau Robert A. Kyle Martha SkinnerThis authoritative volume contains 179 chapters by international experts on recent developments in our understanding of amyloid proteins, protein folding disorders, and new and proposed clinical trials in amyloidosis. Topics include detection and characterization techniques; biological functions; genetics; disorders, diagnosis, and treatments, incl
Amyloid Fibrils and Prefibrillar Aggregates
by Daniel Erik OtzenSumming up almost a decade of biomedical research, this topical and eagerly awaited handbook is the first reference on the topic to incorporate recent breakthroughs in amyloid research.The first part covers the structural biology of amyloid fibrils and pre-fibrillar assemblies, including a description of current models for amyloid formation. The second part looks at the diagnosis and biomedical study of amyloid in humans and in animal models, while the final section discusses pharmacological approaches to manipulating amyloid and also looks at its physiological roles in lower and higher organisms. For Biochemists, Molecular Biologists, Neurobiologists, Neurophysiologists and those working in the Pharmaceutical Industry.
Amyloid Precursor Protein: A Practical Approach
by Weiming Xia Huaxi XuIn the search for an effective treatment for Alzheimer's disease, APP is a unique model protein that illustrates the wide array of basic and sophisticated characterization techniques available. Exploring a variety of biological techniques to clarify the structure and function of this transmembrane protein, this text presents each method with detail
Amyloid Proteins: Methods And Protocols (Methods in Molecular Biology #299)
by Einar M. SigurdssonA proven collection of readily reproducible techniques for studying amyloid proteins and their involvement in the etiology, pathogenesis, diagnosis, and therapy of amyloid diseases. The contributors provide methods for the preparation of amyloid and its precursors (oligomers and protofibrils), in vitro assays and analytical techniques for their study, and cell culture models and assays for the production of amyloid proteins. Additional chapters present readily reproducible techniques for amyloid extraction from tissue, its detection in vitro and in vivo, as well as nontransgenic methods for developing amyloid mouse models. The protocols follow the successful Methods in Molecular BiologyTM series format, each offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.
Amyloid Proteins: Methods and Protocols (Methods in Molecular Biology #1779)
by Einar M. Sigurdsson Miguel Calero María GassetThis third edition volume expands on the previous editions with many new chapters that cover the latest techniques and topics that were not addressed in the previous volumes. The chapters in this book are divided into three parts: Part One covers in vitro assays that focus on a variety of amyloids and how to study these peptides and proteins. Part Two describes cell culture models and assays, and Part Three explores methods on how to extract amyloid from tissue, its detection, and its characterization in vitro or in vivo. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and authoritative, Amyloid Proteins: Methods and Protocols, Third Edition is a valuable resource for both students and scientists who are new to the field, as well as experienced researchers who would like to progress their research with the latest available techniques.
Amyloid Proteins: Methods and Protocols (Methods in Molecular Biology #849)
by Einar M. Sigurdsson María Gasset Miguel CaleroAmyloid diseases are characterized by the deposition of insoluble fibrous amyloid proteins. The word "amyloid" indicates a starch-like compound, and though a misnomer, continues to be the accepted term for this group of protein conformational disorders. The second edition of Amyloid Proteins expands upon the previous edition with current, detailed protocols for the preparation of amyloid and its precursors, specific analytical methods for studying these proteins, cell culture models and assays for production of amyloid proteins, and protocols for amyloid extraction from tissue, its detection in vitro and in vivo, as well as nontransgenic methods for developing amyloid mouse models. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.Authoritative and practical, Amyloid Proteins, Second Edition seeks to aid scientists in the amyloid field to establish new techniques in their laboratories. Authoritative and practical, Amyloid Proteins, Second Edition seeks to aid scientists in the amyloid field to establish new techniques in their laboratories.
AN Optimist's Tour of the Future
by Mark StevensonIn the tradition of Bill Bryson's A Short History of Nearly Everything, a smart and entertaining guide to the future. Mark Stevenson-a writer, deep thinker, and stand-up comedian-set out simply, asking, "What's next for our species?" and then traveled the globe in pursuit of the answers. Along the way, he visited the Australian outback to visit the farmers who can save us from climate change, met a robot with mood swings, and talked to the Spaniard who's putting a hotel in space. While some might be overwhelmed, or even dismayed by the looming realities of genome sequencing, synthetic biology, a nuclear renaissance, and carbon scrubbing, Stevenson remains, well, optimistic. Drawing on his singular humor and storytelling to break down these sometimes complicated discoveries, An Optimist's Tour of the Future paints a wonderfully readable, and completely enthralling portrait of where we'll be when we grow up- and why it's not so scary.
Anabolic Steroids: And Other Performance-enhancing Drugs
by Patrick LenehanAnabolic steroids have traditionally been controversial in the sporting arena. Today, research indicates a dramatic increase in the use of anabolic steroids and other performance-enhancing drugs outside of competitive sports. With evidence of widespread steroid abuse among the general population, health professionals are citing the emergence of an
Anabolic Treatments for Osteoporosis (Handbooks in Pharmacology and Toxicology)
by James F. Whitfield Paul MorleyOsteoporosis, a growing epidemic among women in North America, Europe, and Japan, is a painful, costly disease that has presented a treatment challenge to healthcare professionals. Until recently, therapies have focused on agents that slow bone resorption, and have had only limited success at increasing bone mass.
Anaerobes and Waste Conversion Technologies (Microorganisms for Sustainability #44)
by Shreeshivadasan Chelliapan Santhana Krishnan Vasudeo ZambareThis book covers all aspects of anaerobic waste conversion technologies using anaerobes, particularly in anaerobic digestion and fermentation processes. It provides the latest advances in waste-to-energy techniques for converting solid and liquid wastes to valuable fuel and energy. It goes beyond traditional municipal waste, including energy recovery from various industrial wastewater and biomass. Topics include biomass pretreatment, metabolic pathways, anaerobic reactor design, product recovery, and conversion technology applications. Essential information is provided, and individual chapters are dedicated to each topic. The book assists academicians, postgraduate students, biochemical engineers, environmental engineers, analysts, chemical engineers, and industrial entrepreneurs in acquiring the skills needed for real-time implementation of anaerobic digestion technologies.
Anaerobes in Biotechnology (Advances in Biochemical Engineering/Biotechnology #156)
by Rajni Hatti-Kaul Bo Mattiasson Gashaw MamoThis book review series presents current trends in modern biotechnology. The aim is to cover all aspects of this interdisciplinary technology where knowledge, methods and expertise are required from chemistry, biochemistry, microbiology, genetics, chemical engineering and computer science. Volumes are organized topically and provide a comprehensive discussion of developments in the respective field over the past 3-5 years. The series also discusses new discoveries and applications. Special volumes are dedicated to selected topics which focus on new biotechnological products and new processes for their synthesis and purification. In general, special volumes are edited by well-known guest editors. The series editor and publisher will however always be pleased to receive suggestions and supplementary information. Manuscripts are accepted in English.
Anaerobic Biodigesters for Human Waste Treatment (Environmental and Microbial Biotechnology)
by Mukesh Kumar Meghvansi A. K. GoelThe edited book brings out a comprehensive synthesis of latest scientific literature covering various important aspects of anaerobic biodigesters for human waste management that ranges from latest understanding on fundamental concepts/mechanisms of anaerobic biodigestion, modern tools and techniques used in process evaluation, current strategies being recruited for the performance enhancement, and case studies/ success stories across the world on applications of biodigesters used in human waste treatment. The anaerobic biodigestion is a process of break-down of organic waste by anaerobic microorganisms in absence of the oxygen. This process has been conventionally used for treating various types of organic waste including sewage sludge. After optimizing various process parameters, researchers have developed anaerobic biodigesters that have been successfully used for human waste (nigh soil) treatment. The topic of human waste treatment assumes global significance in the wake of UN sustainable Development Goals (SDG) wherein SDG-6 specifically highlights the Sanitation for all by 2030. The anaerobic Biodigester technology has the potential to manage the human waste as well and can contribute immensely in achieving targets of UN-SDG-6. This book is of interest to researchers, academicians, scientists, policy officials and capacity builders. Also the book serves as additional reading material for undergraduate and graduate students of environmental Biotechnology. National and international biotechnologists, environmental engineers and sanitation experts also find this to be a useful read.
Anaerobic Biotechnology for Bioenergy Production: Principles and Applications
by Samir Kumar KhanalAnaerobic biotechnology is a cost-effective and sustainable means of treating waste and wastewaters that couples treatment processes with the reclamation of useful by-products and renewable biofuels. This means of treating municipal, agricultural, and industrial wastes allows waste products to be converted to value-added products such as biofuels, biofertilizers, and other chemicals. Anaerobic Biotechnology for Bioenergy Production: Principles and Applications provides the reader with basic principles of anaerobic processes alongside practical uses of anaerobic biotechnology options. This book will be a valuable reference to any professional currently considering or working with anaerobic biotechnology options.
Anaerobic Digestion: Fundamentals, Modelling, and Applications (Green Energy and Technology)
by Guangxue WuAnaerobic digestion is a core technology for sustainable waste(water) management and renewable energy recovery from waste sources. This book introduces and brings readers up to date with anaerobic digestion and its applications. It refreshes readers on the fundamentals of anaerobic digestion processes for normal and stressed scenarios, introduces techniques for stable system operation and predication, and explains the innovation in technology applications for waste valorization. By providing scientific and engineering fundamentals, the book equips professionals with the knowledge of knowing why and how to solve the problems in the application of anaerobic digestion.
Anaerobic Fungi: Biology: Ecology, and Function
by Douglas MountfortUniting-for the first time-current information on anaerobic fungi from a number of different disciplines, this unique reference examines the taxonomy, physiology, biochemistry, molecular biology, and ecology of anaerobic fungi-focusing on fungi from the rumen and other gut environments such as the cecum and hindgut of nonruminant herbivores.Anaerobic Fungi Presents new techniques for culturing anaerobic fungi! analyzes the isolation, culture, and survival of anaerobic fungi describes the nucleic acids of anaerobic fungi, gene cloning, and the establishment of molecular phylogeny discusses the fermentation of carbohydrates explains how anaerobic fungi interact with other microorganisms investigates the ultrastructure of plant cell walls degraded by fungi details the effects of diet on fungal populations delineates specific procedures for quantifying anaerobic fungi outlines potential directions for future research in molecular genetics and more!
Anaerobic Oxidation of Methane Coupled to the Reduction of Different Sulfur Compounds as Electron Acceptors in Bioreactors (IHE Delft PhD Thesis Series)
by Chiara CassariniThis research investigated new approaches to control anaerobic methane oxidation coupled to sulfate reduction (AOM-SR) and enrich anaerobic methanotrophs (ANME) and sulfate reducing bacteria (SRB) with the purpose of designing a suitable bioreactor for AOM-SR at ambient pressure and temperature. The current knowledge about AOM and the microorganisms involved in AOM are discussed. The effect of different substrates and pressures was investigated on the ANME and SRB community adapted to the shallow marine Lake Grevelingen, the Netherlands. Further, microorganisms from the Alpha Mound (Spain) deep sediment were enriched with methane gas as substrate in biotrickling filters (BTF) at ambient conditions for 147-230 days of operation. The effect of alternative sulfur compounds (sulfate, thiosulfate and elemental sulfur) were studied and the microbial community was characterized. The highest AOM and sulfate reduction rates were obtained in the BTF fed with thiosulfate as the electron acceptor (~0.4 mmol l-1 day-1), but the highest number of ANME was visualized in the sulfate fed BTF (ANME-2 43% of the total visualized archaea). A BTF was proposed as a suitable bioreactor for the enrichment of ANME and SRB at ambient pressure and temperature which could be potentially used for future biotechnological applications.
Anaerobic Treatment and Resource Recovery from Methanol Rich Waste Gases and Wastewaters (IHE Delft PhD Thesis Series)
by Tejaswini EregowdaMethanol is an important volatile organic compound (VOC) present in the gaseous and liquid effluents of process industries such as pulp and paper, paint manufacturing and petroleum refineries. An estimated 65% of the total methanol emission was from the Kraft mills of the pulp and paper industries. The effect of selenate, sulfate and thiosulfate on methanol utilization for volatile fatty acids (VFA) production was individually examined in batch systems. Gas-phase methanol removal along with thiosulfate reduction was carried out for 123 d in an anoxic BTF. To examine the gas-phase methanol removal along with selenate reduction, another anoxic biotrickling filter (BTF) was operated for 89 d under step and continuous selenate feeding conditions. For the study on liquid-phase methanol, acetogenesis of foul condensate (FC) obtained from a chemical pulping industry was tested in three upflow anaerobic sludge blanket (UASB) reactors operated at 22, 37 and 55 ºC for 51 d. The recovery of VFA was explored through adsorption studies using anion exchange resins in batch systems. The adsorption capacity of individual VFA on Amberlite IRA-67 and Dowex optipore L-493 was examined by fitting the experimental data to adsorption isotherms and kinetic models. A sequential batch process was tested to achieve selective separation of acetic acid from the VFA mixture.
Anaerobic Treatment of Mine Wastewater for the Removal of Selenate and its Co-Contaminants (IHE Delft PhD Thesis Series)
by Lea Chua TanSelenium (Se) pollution has led to several cases of severe aquatic ecosystem deterioration due to Se poisoning caused by bioaccumulation over time. However, the removal of selenate (SeO42-) from wastewater streams with co-contaminants has been largely considered as a black box in anaerobic biological systems using mixed consortia. This research aimed at addressing the effect of wastewater characteristics, i.e. co-contaminants such as nitrate (NO3-) and sulfate (SO42-), heavy metals and pH, on the biological reduction of SeO42- and evaluating process integration for Se-laden wastewater treatment with co-contaminants. This study demonstrated that the presence of co-contaminants can actually be beneficial for Se removal provided that the concentrations are carefully monitored and appropriate operating conditions and process configurations are used. The Se removal (total Se and SeO42-) efficiency increased by ~30% in the presence of NO3- and/or SO42- compared to systems with SeO42- alone. Additionally, an integrated process of an ion exchange (IX) column and bioreactors showed improved overall removal capacity for SO42- and total Se. The knowledge and information gained from this research can help in the advancement and application of biological processes, i.e. predicting of reactor performance, solving specific design or practical problems and implementing novel treatment techniques for Se-laden mine wastewater.
Anaerobic Waste-Wastewater Treatment and Biogas Plants: A Practical Handbook
by Joseph Chukwuemeka AkunnaThe book guides specialists and non-specialists from around the world on how or whether anaerobic processes can be part of solutions for the management of municipal and industrial solid, semi-solid, and liquid residues. The simple self-learning presentation style is designed to encourage deep understanding of the process principles, plant types and system configurations, performance capabilities, operational and maintenance requirements, post-treatment needs, and management options for coproducts without complex biochemical terminologies and equations. It describes key aerobic biological treatment processes used in conjunction with anaerobic biological treatment in feedstock pre-treatment and in post-treatment of by-products. Practical pre-treatment processes, techniques and operations are described alongside additional treatment techniques of biogas, digestates and treated effluents for various end use options. Effective applications in developing countries are also considered, enabling practitioners and plant operators to effectively apply technology in temperate and warm climatic conditions.