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How Your Body Works: A Good Look Inside Your Insides
by David StewartWhat, Why, and How is explained with respect to human body.
How Your Brain Works: Neuroscience Experiments for Everyone
by Greg Gage Tim MarzulloDiscover the hidden electrical world inside your nervous system using DIY, hands-on experiments, for all ages. No MD or PhD required!The workings of the brain are mysterious: What are neural signals? What do they mean? How do our senses really sense? How does our brain control our movements? What happens when we meditate? Techniques to record signals from living brains were once thought to be the realm of advanced university labs . . . but not anymore! This book allows anyone to participate in the discovery of neuroscience through hands-on experiments that record the hidden electrical world beneath our skin and skulls. In How Your Brain Works, neuroscientists Greg Gage and Tim Marzullo offer a practical guide—accessible and useful to readers from middle schoolers to college undergraduates to curious adults—for learning about the brain through hands-on experiments. Armed with some DIY electrodes, readers will get to see what brain activity really looks like through simple neuroscience experiments. Written by two neuroscience researchers who invented open-source techniques to record signals from neurons, muscles, hearts, eyes, and brains, How Your Brain Works includes more than forty-five experiments to gain a deeper understanding of your brain. Using a homemade scientific instrument called a SpikerBox, readers can see how fast neural signals travel by recording electrical signals from an earthworm. Or, turning themselves into subjects, readers can strap on some electrode stickers to detect the nervous system in their own bodies. Each chapter begins by describing some phenomenology of a particular area of neuroscience, then guides readers step-by-step through an experiment, and concludes with a series of open-ended questions to inspire further investigation. Some experiments use invertebrates (such as insects), and the book provides a thoughtful framework for the ethical use of these animals in education. How Your Brain Works offers fascinating reading for students at any level, curious readers, and scientists interested in using electrophysiology in their research or teaching.Example Experiments • How fast do signals travel down a neuron? The brain uses electricity . . . but do neurons communicate as fast as lightning inside our bodies? In this experiment you will make a speed trap for spikes! • Can we really enhance our memories during sleep? Strap on a brainwave-reading sweatband and test the power of cueing up and strengthening memories while you dream away! • Wait, that&’s my number! Ever feel that moment of excitement when you see your number displayed while waiting for an opening at the counter? In this experiment, you will peer into your brainwaves to see what happens when the unexpected occurs and how the brain gets your attention. • Using hip hop to talk to the brain. Tired of simply &“reading&” the electricity from the brain? Would you like to &“write&” to the nervous system as well? In this experiment you will use a smartphone and hack a headphone cable to see how brain stimulators (used in treating Parkinson&’s disease) really work. • How long does it take the brain to decide? Using simple classroom rulers and a clever technique, readers can determine how long it takes the brain to make decisions.
How Your Brain Works: Inside the most complicated object in the known universe
by New ScientistEver wondered what's going on inside your head?You are your brain. Everything that makes you you, and all your experiences of the world, are somehow conjured up by 1.4 kilograms of grey matter inside your skull. That might seem impossible, but science has advanced so much that we now understand not just its structures and inner workings but also how it can give rise to perception, consciousness, emotions, memories, intelligence, sleep and more. HOW YOUR BRAIN WORKS explores the amazing world inside your head. Discover the evolution and anatomy of the brain. Learn how we can peer inside it and watch it at work, and how the latest technology can allow us to control our minds and those of others. ABOUT THE SERIESNew Scientist Instant Expert books are definitive and accessible entry points to the most important subjects in science; subjects that challenge, attract debate, invite controversy and engage the most enquiring minds. Designed for curious readers who want to know how things work and why, the Instant Expert series explores the topics that really matter and their impact on individuals, society, and the planet, translating the scientific complexities around us into language that's open to everyone, and putting new ideas and discoveries into perspective and context.
How Your Brain Works: Inside the most complicated object in the known universe (New Scientist Instant Expert)
by New ScientistEver wondered what's going on inside your head?You are your brain. Everything that makes you you, and all your experiences of the world, are somehow conjured up by 1.4 kilograms of grey matter inside your skull. That might seem impossible, but science has advanced so much that we now understand not just its structures and inner workings but also how it can give rise to perception, consciousness, emotions, memories, intelligence, sleep and more. HOW YOUR BRAIN WORKS explores the amazing world inside your head. Discover the evolution and anatomy of the brain. Learn how we can peer inside it and watch it at work, and how the latest technology can allow us to control our minds and those of others. ABOUT THE SERIESNew Scientist Instant Expert books are definitive and accessible entry points to the most important subjects in science; subjects that challenge, attract debate, invite controversy and engage the most enquiring minds. Designed for curious readers who want to know how things work and why, the Instant Expert series explores the topics that really matter and their impact on individuals, society, and the planet, translating the scientific complexities around us into language that's open to everyone, and putting new ideas and discoveries into perspective and context.
How Your Brain Works: Inside the most complicated object in the known universe (New Scientist Instant Expert)
by New ScientistIn How Your Brain Works leading neuroscientists and New Scientist introduce the evolution and anatomy of the brain viewed through traits such as: memory, emotions, sleep, sensing and perception.Ever wondered what's going on inside your head?You are your brain. Everything that makes you you, and all your experiences of the world, are somehow conjured up by 1.4 kilograms of grey matter inside your skull. That might seem impossible, but science has advanced so much that we now understand not just its structures and inner workings but also how it can give rise to perception, consciousness, emotions, memories, intelligence, sleep and more. HOW YOUR BRAIN WORKS explores the amazing world inside your head. Discover the evolution and anatomy of the brain. Learn how we can peer inside it and watch it at work, and how the latest technology can allow us to control our minds and those of others. ABOUT THE SERIESNew Scientist Instant Expert books are definitive and accessible entry points to the most important subjects in science; subjects that challenge, attract debate, invite controversy and engage the most enquiring minds. Designed for curious readers who want to know how things work and why, the Instant Expert series explores the topics that really matter and their impact on individuals, society, and the planet, translating the scientific complexities around us into language that's open to everyone, and putting new ideas and discoveries into perspective and context.(P) 2017 Hodder & Stoughton Limited
How Your Brain Works: Inside The Most Complicated Object In The Universe (New Scientist Instant Expert Ser. #41)
by Caroline WilliamsEver wondered what's going on inside your head? The brain has long been a source of fascination. In 1819, the radical thinker and surgeon William Lawrence put it like this: "It is strongly suspected that a Newton or Shakespeare excels other mortals only... by having an extra inch of brain in the right place." Today, many such suspicions are certainties. We understand the structures of the brain, minor and major, and their roles in making us who we are. We can record electrical signals from individual brain cells or networks of them. Imaging technology lets us see both snapshots of the brain and also videos of it in action. We can follow connections within the brain and watch them reform after an injury. How Your Brain Works explores what's going on inside your head, and what makes you, you. It looks at techniques for controlling the brain using electric and magnetic fields, as well as investigating the latest technologies that allow you to control the outside world using your mind alone.
Howell's Storm: New York City's Official Rainmaker and the 1950 Drought
by Jim LeekeMore than half a century ago, New York City felt the increasing effects of drought, which lasted throughout 1949 and into 1950. By February, the desperate city had to try something different. Mayor William O'Dwyer hired a municipal rainmaker. Dr. Wallace E. Howell was an inspired choice. The handsome, 35-year-old Harvard-educated meteorologist was the ideal scientist—soft-spoken, modest and articulate. No fast-talking prairie huckster, he took credit for nothing he couldn't prove with sound empirical data. Howell's meticulous nature often baffled jaded New Yorkers. Over the next year, his leadership of a small ground and air armada, and his unprecedented scientific campaign to replenish the city's Catskills reservoirs, captured the imagination of the world. New York's cloud-seeding and rainmaking efforts would remain the stuff of legends—and controversy—for decades.This is the first in-depth look at New York City's only official rainmaker—an unintentional celebrity, dedicated scientist and climate entrepreneur, whose activities stirred up controversy among government officials, meteorologists, theologians, farmers and resort owners alike.
Howl like a Wolf!: Learn about 13 Wild Animals and Explore Their Lives through Creative Play and Activities
by Kathleen YaleThe paperback edition of the award-winning Howl Like a Wolf! is an interactive, beautifully illustrated book that takes children on a journey into the animal kingdom, with engaging explanations of the distinctive habits and behaviors of thirteen different mammals, reptiles, and insects, from the bee and skunk to the whale, octopus, and bower bird. The animals introduce themselves, then invite kids to mimic each animal's movements, sounds, and behaviors. Eleven colorful, child-size pop-out masks are included, ready to wear with the addition of a string or elastic. This publication conforms to the EPUB Accessibility specification at WCAG 2.0 Level AA.
Howl like a Wolf!: Learn to Think, Move, and Act Like 15 Amazing Animals
by Kathleen Yale Kaley McKeanWhat does it feel like to “see” with your ears like a bat or go through a full body transformation like a frog? Can you wriggle in and out of tight places like an octopus, camouflage yourself like a leopard, or do a waggle dance like a honeybee? This creative and beautifully illustrated interactive guide makes learning about animals fun for children ages 6 and up. Fifteen animals explain their amazing feats and invite kids to enter their world by mimicking their behavior — an imaginative approach to learning that fosters curiosity, empathy, and dramatic play.
Howler Monkeys
by Dionisios Youlatos Bernardo Urbani Liliana Cortés-Ortiz Paul A. Garber Martín M. KowalewskiHowler monkeys (genus Alouatta) comprise twelve species of leaf-eating New World monkeys that range from southern Mexico through northern Argentina. This genus is the most widespread of any New World primate taxa, and can be found to inhabit a range of forest types from undisturbed rainforest to severely anthropogenically impacted forest fragments. Although there have been many studies on individual species of howler monkeys, this book is the first comprehensive volume to place information on howler behavior and biology within a theoretical framework of ecological and social adaptability. This is the second of two volumes devoted to the genus Alouatta. This volume: · Examines behavioral and physiological mechanisms that enable howler monkeys to exploit highly disturbed and fragmented habitats · Presents models of howler monkey diet, social organization, and mating systems that can also inform researchers studying Old World colobines, apes, and other tropical mammals These goals are achieved in a collection of chapters written by a distinguished group of scientists on the feeding ecology, behavior, mating strategies, and management and conservation of howlers. This book also contains chapters on the howler microbiome, the concept of behavioral variability, sexual selection, and the role of primates in forest regeneration.
How's It Hanging?: Expert Answers to the Questions Men Don't Always Ask
by Neil BaumThis book is a great asset to all men who need to make their own health a priority."?Joe Gibbs, NFL Hall of Fame coach and owner of 4x NASCAR champion Joe Gibbs RacingEverything you need to know about men's health in one handy package.In their decades of clinical practice, Dr. Neil Baum and Dr. Scott Miller have treated sexual problems, prostate problems, urinary leakage, pelvic pain, urinary tract infections, and questions about infertility. They have seen countless male patients describe the problem simply as "something's not right down there," either because they are embarrassed about the issues or unaware of them. How's It Hanging? provides an easy-to-read guide to men's health. It is a sorely needed reference, during their lifetime 50 percent of men will have one of more of the conditions discussed in the book. With an appropriate use of humor, analogies, illustrations, and case examples, the doctors share their knowledge of the penis, prostate, and testicles. They start with a discussion of male anatomy, covering the different organs, tubes, and hormones. They then move on to cover various problems, including erectile dysfunction, premature ejaculation, cancer, testosterone deficiency, STDs, and how they can be treated.How's It Hanging? will help men make informed decisions about their medical care. Instead of suffering in silence, they will be more likely to discuss these issues with their friends and family and seek help when needed. And they will be better patients, able to communicate with their physicians about what's going on "down there."
Hox Genes
by Yacine Graba René RezsohazyHox Genes: Methods and Protocols explores techniques and methodologies which arose from or were successfully applied to the study of Hox genes and Hox proteins, at the intersection of experimental embryology, genetics, biochemistry, physiology, evolutionary biology and other life sciences. This detailed volume begins with a section on discovery and functional analysis of Hox genes and then it continues onward to discuss mode of action and biomedical applications of Hox proteins. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls. Expert and practical, Hox Genes: Methods and Protocols serves as an ideal guide to researchers striving to move forward in this dynamic and exciting area of study.
Hox Modules in Evolution and Development (Evolutionary Cell Biology)
by Ferrier, David E. K.Few, if any, genes have had the same level of impact on the field of evolutionary-developmental biology (evo-devo) as the Hox genes. These genes are renowned for their roles in patterning the body plans and development of the animal kingdom. This is complemented by the distinctive organisation of these genes in the genome, with them frequently being found as clusters in which gene position is linked to when and where the individual genes are expressed, particularly during embryogenesis. This book provides the latest overviews of Hox gene organisation and function for major clades of animals from across the animal kingdom. With the rapidly increasing availability of high-quality whole genome sequences from an ever-expanding range of species, it is becoming increasingly evident that there is great diversity in the organisation of Hox genes. These great strides in genome sequencing are wedded to important developments in our ability to detect expression and disrupt gene function in species that are not traditionally genetically-amenable animals. These technical developments are integrated with wide taxon-sampling in this volume to provide new perspectives on the roles of Hox genes in understanding fundamental issues such as embryo patterning, mechanisms of gene regulation, homology, evolvability, evolutionary novelties, phylogeny, the role of gene and genome duplications in evolution, and ancestral states for major clades of animals. Key features Integrative overviews from major animal groups including, arthropods, vertebrates, echinoderms, mollusks and other spiralians. Perspectives gleaned from the latest genome sequence and gene expression data. Individual chapters written by world-leading experts in Hox genes and evo-devo in each animal group. Related Titles Scholtz, G., ed. Evolutionary Developmental Biology of Crustacea (ISBN 978-9-0580-9637-1) Mattick, J. & P. Amaral. RNA, The Epicenter of Genetic Information (ISBN 978-0-3675-6778-1) Bard, J. Evolution: The Origins and Mechanisms of Diversity (ISBN 978-0-3673-5701-6)
HPHT-Treated Diamonds
by Victor. G. Vins Inga A. Dobrinets Alexander M. ZaitsevHigh-temperature and high-pressure treatment of diamond is becoming an important technology to elaborate diamonds. This is the first book providing a comprehensive review of the properties of HPHT-treated diamonds, based on the analysis of published data and the work of the authors. The book gives a detailed analysis of the physics of transformation of internal structures of diamonds subjected to HPHT treatment and discusses how these transformations can be detected using methods of optical microscopy and spectroscopy. It also gives practical recommendations for the recognition of HPHT-treated diamonds. The book is written in a language and terms which can be understood by a broad audience of physicists, mineralogists and gemologists.
HPLC and UHPLC for Practicing Scientists
by Michael DongWritten for practitioners by an expert practitioner, this new edition of HPLC and UHPLC for Practicing Scientists adds numerous updates to its coverage of high-performance liquid chromatography, including comprehensive information on UHPLC (ultra-high-pressure liquid chromatography) and the continuing migration of HPLC to UHPLC, the modern standard platform. In addition to introducing readers to HPLC’s fundamentals, applications, and developments, the book describes basic theory and terminology for the novice, and reviews relevant concepts, best practices, and modern trends for the experienced practitioner. <p><p> HPLC and UHPLC for Practicing Scientists, Second Edition offers three new chapters. One is a standalone chapter on UHPLC, covering concepts, benefits, practices, and potential issues. Another examines liquid chromatography/mass spectrometry (LC/MS). The third reviews at the analysis of recombinant biologics, particularly monoclonal antibodies (mAbs), used as therapeutics. While all chapters are revised in the new edition, five chapters are essentially rewritten (HPLC columns, instrumentation, pharmaceutical analysis, method development, and regulatory aspects). The book also includes problem and answer sections at the end of each chapter. <p> Filled with intuitive explanations, case studies, and clear figures, HPLC and UHPLC for Practicing Scientists, Second Edition is an essential resource for practitioners of all levels who need to understand and utilize this versatile analytical technology. It will be a great benefit to every busy laboratory analyst and researcher.
The HPLC Expert: Possibilities and Limitations of Modern High Performance Liquid Chromatography
by Stavros KromidasThe rapid development of HPLC instrumentation and technology opens numerous possibilities - and entails new questions. Which column should I choose to obtain best results, which gradient fits to my analytical problem, what are recent and promising trends in detection techniques, what is state of the art regarding LC-MS coupling? All these questions are answered by experts in ten self-contained chapters. Besides these more hardware-related and technical chapters, further related areas of interest are covered: Comparison of recent chromatographic data systems and integration strategies, smart documentation, efficient information search in internet, and tips for a successful FDA inspection. This practical approach offers in a condensed manner recent trends and hints, and will also display the advanced reader mistakes and errors he was not aware of so far.
The HPLC-Expert II: Optimizing the Benefits of HPLC/UHPLC
by Stavros KromidasHow can I use my HPLC/UHPLC equipment in an optimal way, where are the limitations of the technique? These questions are discussed in detail in the sequel of the successful "HPLC Expert" in twelve chapters written by experts in the respective fields. The topics encompass - complementary to the first volume - typical HPLC users' problems and questions such as gradient optimization and hyphenated techniques (LC-MS). An important key aspect of the book is UHPLC: For which analytical problem is it essential, what should be considered? Besides presentation of latest developments directly from the main manufacturers, also UHPLC users and independent service engineers impart their knowledge. Consistent with the target groups, the level is advanced, but the emphasis is on practical applications.
HPLC in Nucleic Acid Research: Methods and Applications (Chromatographic Science Ser. #28)
by Phyllis R. BrownThis book gives the pertinent information on the high pressure liquid chromatography (HPLC) analyses of all the compounds of interest in nucleic acid metabolism. It aids chromatographers, biochemists, biomedical researchers, and chemists by giving information on applications of HPLC technique.
HPLC in the Pharmaceutical Industry (Drugs And The Pharmaceutical Sciences Ser. #47)
by Godwin W Fong Stanley K. LamA practical guide for chemists in the pharmaceutical industry to making automated analyses of drugs that will meet the standards of regulatory agencies. Reviews the standard techniques of high-performance liquid chromatography, specialized detection methods, automation in pharmaceutical analysis, analyses of pharmaceuticals- helping readers meet rigorous regulatory agency standards for acceptable test results. Written by leading experts in the field, this text describes current liquid chromatographic techniques in pharamaceutical analysis...discusses highly sensitve detailed detection of drugs... considers automatation in pharamaceutical analysis...examines new molecular entities and opitcal isomers... and more.
The HPLC-MS Handbook for Practitioners
by Stavros KromidasFilling the gap for an expert text dealing exclusively with the practical aspects of HPLC-MS coupling, this concise, compact, and clear book provides detailed information to enable users to employ the method most efficiently. Following an overview of the current state of HPLC-MS and its instrumentation, the text goes on to discuss all relevant aspects of method development. A chapter on tips and tricks is followed by user reports on the advantages - and pitfalls - of applying the method in real-life scenarios. The whole is rounded off by a look at future developments by renowned manufacturers.
HPLC of Peptides and Proteins
by Marie-Isabel AguilarHands-on experts from academia and industry comprehensively describe how to successfully perform all the critical HPLC techniques needed for the analysis of peptides and proteins. The methods range from commonly used techniques to those for capillary to large-scale preparative isolation. The authors have also presented a number of specific applications as case studies to illustrate the analytical approaches to a particular separation or assay challenge, with examples drawn from contemporary fields in biochemistry and biotechnology.
HPLC optimal einsetzen: Konzepte und Strategien für Methodenentwicklung und -optimierung
by Stavros KromidasDieser Praxisratgeber bietet erprobte Strategien für die Optimierung der HPLC und UHPLC in unterschiedlichsten Einsatzgebieten. Im ersten Teil werden Optimierungsstrategien für unterschiedliche Betriebsarten und Analyte behandelt, von Kleinmolekülen bis hin zu chiralen Substanzen und Biomolekülen. Der zweite Teil beschreibt die rechnergestützte Optimierung und stellt die gängigen Software-Tools und deren Leistungsspektrum vor. Weitere Teile beschreiben Optimierungsstrategien aus Sicht von Routineanwendern in großen Industrie- und kleineren Auftragslaboren sowie aus Sicht verschiedener Gerätehersteller. Dieser Leitfaden ist gleichermaßen für Einsteiger wie für routinierte Anwender geschrieben und lässt keine Frage zum optimalen Einsatz der HPLC unbeantwortet.
HPLC richtig optimiert: Ein Handbuch für Praktiker
by Stavros KromidasNeben der Methodenentwicklung ist die Optimierung bestehender Methoden eine zentrale Aufgabe im HPLC-Labor. Eine Aufgabe, die heute in immer kurzerer Zeit und kosteneffizient erledigt werden muss. Das Handbuch bietet eine fundierte Hilfe, um diese Herausforderung noch besser zu meistern. International renommierte Autoren behandeln sowohl die allgemeinen Grundlagen und Strategien der Optimierung als auch die spezifischen Aspekte der unterschiedlichen Techniken wie RP-HPLC, NP-HPLC, Micro- und Nano-HPLC sowie der Kopplungstechniken wie LC-MS. Auch die richtige Saulenauswahl sowie Enantiomerentrennungen gehoren zu den behandelten Themen. Die Autoren liefern konkrete, praktische Tipps ebenso wie relevante Hintergrundinformationen. Sie bieten daruber hinaus Einblicke in die Optimierungspraxis sieben international renommierter Firmen verschiedener Branchen. Einige Beitrage stellen die Anwendung gangiger Optimierungssoftware wie DryLab oder ChromSword dar. Das ganze wird abgerundet durch praxisnahe Berichte erfahrener Anwender aus den verschiedenen Anwendungsgebieten, inbesondere aus den Life Sciences, wie beispielsweise Proteomics oder Pharmaentwicklung. Alle Beitrage sind in einem auf das Wesentliche konzentrierten und anwendungsnahen Stil geschrieben. Der Aufbau des Buches mit abgeschlossenen Kapiteln erleichtert das gezielte Nachschlagen.
HSF1 and Molecular Chaperones in Biology and Cancer (Advances in Experimental Medicine and Biology #1243)
by David Pincus Marc Laurence Mendillo Ruth Scherz-ShouvalProtein homeostasis, or “Proteostasis”, lies at the heart of human health and disease. From the folding of single polypeptide chains into functional proteins, to the regulation of intracellular signaling pathways, to the secreted signals that coordinate cells in tissues and throughout the body, the proteostasis network operates to support cell health and physiological fitness. However, cancer cells also hijack the proteostasis network and many of these same processes to sustain the growth and spread of tumors. The chapters in this book are written by world experts in the many facets of the proteostasis network. They describe cutting-edge insights into the structure and function of the major chaperone and degradation systems in healthy cells and how these systems are co-opted in cancer cells and the cells of the tumor microenvironment. The chapters also cover therapeutic interventions such as the FDA-approved proteasome inhibitors Velcade and Krypolis as well as other therapies currently under clinical investigation to disarm the ability of the proteostasis network to support malignancy. This compendium is the first of its kind and aims to serve as a reference manual for active investigators and a primer for newcomers to the field. This book is dedicated to the memory of Susan Lindquist, a pioneer of the proteostasis field and a champion of the power of basic scientific inquiry to unlock the mechanisms of human disease.
HSLA Steels 2015, Microalloying 2015 and Offshore Engineering Steels 2015
by The Chinese Society for MetalsHSLA Steels 2015, Microalloying 2015 and Offshore Engineering Steels 2015 Conference Proceedings, Held November 11-13th, 2015, Hangzhou, Zhejiang Province, China