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Hypertension and Heart Failure: Epidemiology, Mechanisms and Treatment (Updates in Hypertension and Cardiovascular Protection)
by Maria Dorobantu Victor Voicu Guido Grassi Enrico Agabiti-Rosei Giuseppe ManciaThe second edition of this well-received book will offer both new insights into the intimate mechanisms of transition from hypertension to heart failure and clinical practice advice on the prevention and treatment of heart failure in hypertensive population. Heart failure is the result of the hypertension's effects on the heart and it is a growing public health problem, as it affects 20-50% of the adult population in developed countries. In this context the international scientific community is continuously struggling to develop better strategies in screening, diagnosing and treating hypertension and its deleterious effects. Thus, this field is continuously changing, with new important information being added constantly. A part of the book dedicated to diagnostics, comprising a chapter on new perspectives on multimodality imaging and a special chapter on diastolic dysfunction. The arrhythmic complications of hypertensive heart disease are discussed in two chapters on atrial fibrillation and ventricular arrhythmias respectively. Readers will also find new chapters regarding hypertension and heart failure in special populations such as cancer patients, young patients, pregnancy and patients with a history of SARS-CoV2 infection. This book is a useful tool for clinicians but also to the research community interested in heart failure and consequences of hypertension on heart who want to be up-to-date with the new developments in the field.
Hypertension in the Dog and Cat
by Jonathan Elliott Harriet M. Syme Rosanne E. JepsonThis book provides an in-depth review on various aspects of canine and feline hypertension. Physiology, pathophysiology, epidemiology and pathological consequences of high blood pressure in cats and dogs are discussed. A comparative approach is taken, the underpinning research is critically evaluated and knowledge gaps identified. In addition, the reader is presented with evidence-based treatment strategies. The book targets researchers, graduate students and clinical specialists in small animal internal medicine as well as veterinary clinicians with interest in nephrology, cardiology, neurology and ophthalmology.
Hypervalent Iodine Chemistry
by Thomas WirthThe series Topics in Current Chemistry presents critical reviews of the present and future trends in modern chemical research. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field. Review articles for the individual volumes are invited by the volume editors. Readership: research chemists at universities or in industry, graduate students.
Hypervalent Iodine Chemistry
by Viktor V. ZhdankinHypervalent Iodine Chemistry is the first comprehensive text covering all of the main aspects of the chemistry of organic and inorganic polyvalent iodine compounds, including applications in chemical research, medicine, and industry.Providing a comprehensive overview of the preparation, properties, and synthetic applications of this important class of reagents, the text is presented in the following way: The introductory chapter provides a historical background and describes the general classification of iodine compounds, nomenclature, hypervalent bonding, structural features, and the principles of reactivity of polyvalent iodine compounds.Chapter 2 gives a detailed description of the preparative methods and structural features of all known classes of organic and inorganic derivatives of polyvalent iodine.Chapter 3, the key chapter of the book, deals with the many applications of hypervalent iodine reagents in organic synthesis.Chapter 4 describes the most recent achievements in hypervalent iodine catalysis.Chapter 5 deals with recyclable polymer-supported and nonpolymeric hypervalent iodine reagents.Chapter 6 covers the "green" reactions of hypervalent iodine reagents under solvent-free conditions or in aqueous solutions.The final chapter provides an overview of the important practical applications of polyvalent iodine compounds in medicine and industry.This book is aimed at all chemists interested in iodine compounds, including academic and industrial researchers in inorganic, organic, physical, medicinal, and biological chemistry. It will be particularly useful to synthetic organic and inorganic chemists, including graduate and advanced undergraduate students. It comprehensively covers the green chemistry aspects of hypervalent iodine chemistry, making it especially useful for industrial chemists.
Hypervelocity Launchers
by Friedrich Seiler Ozer IgraIn the present volume numerous descriptions of Ram accelerators are presented. These descriptions provide good overview on the progress made and the present state of the Ram accelerator technology worldwide. In addition, articles describing light gas gun, ballistic range including a chapter dealing with shock waves in solids are given. Along with the technical description of considered facilities, samples of obtained results are also included. Each chapter is written by an expert in the described topic providing a comprehensive description of the discussed phenomena.
Hyphenated and Alternative Methods of Detection in Chromatography (Chromatographic Science Ser.)
by R. Andrew ShallikerWidely employed for separating and detecting chemicals in solution, separation techniques are most often applied in tandem, subsequently referred to as hyphenated methods. Hyphenated and Alternative Methods of Detection in Chromatography details the development and application of mass spectral detection techniques coupled with gas phase and liquid
Hyping Health Risks: Environmental Hazards in Daily Life and the Science of Epidemiology
by Geoffrey KabatThe media constantly bombard us with news of health hazards lurking in our everyday lives, but many of these hazards turn out to have been greatly overblown. According to author and epidemiologist Geoffrey C. Kabat, this hyping of low-level environmental hazards leads to needless anxiety and confusion on the part of the public concerning which exposures have important effects on health and which are likely to have minimal or no effect. Kabat approaches health scares as "social facts" and shows that a variety of factors can contribute to the inflating of a hazard. These include skewed reporting by the media, but also, surprisingly, the actions of researchers who may emphasize certain findings while ignoring others; regulatory and health agencies eager to show their responsiveness to the health concerns of the public; and politicians and advocates with a stake in a particular outcome. By means of four case studies, Kabat demonstrates how a powerful confluence of interests can lead to overstating or distorting the scientific evidence. He considers the health risks of pollutants such as DDT as a cause of breast cancer, electromagnetic fields from power lines, radon within residences, and secondhand tobacco smoke. Tracing the trajectory of each of these hazards from its initial emergence to the present, Kabat shows how publication of more rigorous studies and critical assessments ultimately help put hazards in perspective.
Hyping Health Risks: Environmental Hazards in Daily Life and the Science of Epidemiology
by Geoffrey C. KabatAccording to author and epidemiologist Geoffrey C. Kabat, this hyping of low-level environmental hazards leads to needless anxiety and confusion on the part of the public as to which exposures have important effects on health.
Hypotheses and Perspectives in the History and Philosophy of Science
by Raffaele Pisano Joseph Agassi Daria DrozdovaTo commemorate the 50th anniversary of his passing (in 2014), this special book features studies on Alexandre Koyr#65533; (1892-1964), one of the most influential historians of science of the 20th century, who re-evaluated prevalent thinking on the history and philosophy of science. In particular, it explores Koyr#65533;'s intellectual matrix and heritage within interdisciplinary fields of historical, epistemological and philosophical scientific thought. Koyr#65533; is rightly noted as both a versatile historian on the birth and development of modern science and for his interest in philosophical questions on the nature of scientific knowledge. In the 1940s and 1950s his activities in the United States established a crucial bridge between the European historical tradition of science studies and the American academic environments, and an entire generation of historians of science grew up under his direct influence. The book brings together contributions from leading experts in the field, and offers much-needed insights into the subject from historical, nature of science, and philosophical perspectives. It provides an absorbing and revealing read for historians, philosophers and scientists alike.
Hypothesis Generation and Interpretation: Design Principles and Patterns for Big Data Applications (Studies in Big Data #139)
by Hiroshi IshikawaThis book focuses in detail on data science and data analysis and emphasizes the importance of data engineering and data management in the design of big data applications. The author uses patterns discovered in a collection of big data applications to provide design principles for hypothesis generation, integrating big data processing and management, machine learning and data mining techniques. The book proposes and explains innovative principles for interpreting hypotheses by integrating micro-explanations (those based on the explanation of analytical models and individual decisions within them) with macro-explanations (those based on applied processes and model generation). Practical case studies are used to demonstrate how hypothesis-generation and -interpretation technologies work. These are based on “social infrastructure” applications like in-bound tourism, disaster management, lunar and planetary exploration, and treatment of infectious diseases. The novel methods and technologies proposed in Hypothesis Generation and Interpretation are supported by the incorporation of historical perspectives on science and an emphasis on the origin and development of the ideas behind their design principles and patterns. Academic investigators and practitioners working on the further development and application of hypothesis generation and interpretation in big data computing, with backgrounds in data science and engineering, or the study of problem solving and scientific methods or who employ those ideas in fields like machine learning will find this book of considerable interest.
The Hypothetical Species: Variables of Human Evolution
by Michael Charles Tobias Jane Gray MorrisonThis book is a provocative and invigorating real-time exploration of the future of human evolution by two of the world’s leading interdisciplinary ecologists – Michael Charles Tobias and Jane Gray Morrison. Steeped in a rich multitude of the sciences and humanities, the book enshrines an elegant narrative that is highly empathetic, personal, scientifically wide-ranging and original. It focuses on the geo-positioning of the human Self and its corresponding species. The book's overarching viewpoints and poignant through-story examine and powerfully challenge concepts associated historically with assertions of human superiority over all other life forms. Ultimately, The Hypothetical Species: Variables of Human Evolution is a deeply considered treatise on the ecological and psychological state of humanity and her options – both within, and outside the rubrics of evolutionary research – for survival. This important work is beautifully presented with nearly 200 diverse illustrations, and is introduced with a foreword by famed paleobiologist, Dr. Melanie DeVore.
Hypoxia and Cancer Metastasis (Advances in Experimental Medicine and Biology #1136)
by Daniele M. GilkesThe present book is an attempt to provide a detailed review of studies that clarify our current understanding of the role of hypoxia in the progression of primary cancer to metastatic disease. It will enable researchers to discover the critical cellular changes that occur under hypoxic conditions and play a role in metastatic dissemination, from the activation of hypoxia-inducible factors, HIF-1 and HIF-2, to the transcriptional profile changes that occur in cancer cells and promote cancer cell survival under detrimental conditions. Readers will discover the methods and challenges involved in imaging and quantifying the degree of hypoxia in a primary tumor. We will provide an understanding of the hypoxia-induced phenotypes that influence heterogeneity, alter the secretome and tumor microenvironment, modify cellular metabolism, and promote immune suppression and resistance to chemotherapy. Finally, we will uncover the therapeutic strategies that are being devised to target the hypoxic microenvironment in the hopes of preventing metastasis and improving the efficacy of standard-of-care cancer treatments. This work is an up to date source of information on the challenges and complexity of the hypoxic tumor microenvironment. Basic and translational scientists, post-doctoral fellows, graduate students, and those interested in how tumors metastasize will find this book a reference that details how hypoxia influences metastatic disease.
Hypoxia in the Northern Gulf of Mexico
by James Sanders Clifford S. Snyder Hans Paerl Mark David William Crumpton Denis Gilbert Alan Blumberg Daniel J. Conley Andrew N. Sharpley Thomas Bianchi Thomas W. Simpson Thomas Armitage Donelson Wright Holly Stallworth Catherine L. Kling Virginia H. Dale David Wangsness Kenneth Reckhow Kyle Mankin Richard Lowrance Robert W. Howarth Judith L. Meyer Walter Boynton James OpaluchThe goal of the book is to examine scientific advances since 2000 that may have increased understanding and options in three general areas related to hypoxia: Characterization the Cause(s) of Hypoxia. The physical, biological and chemical processes that affect the development, persistence and extent of hypoxia in the northern Gulf of Mexico. Characterization of Nutrient Fate, Transport and Sources. Nutrient loadings, fate, transport and sources in the Mississippi River that impact Gulf Hypoxia. Scientific Basis for Goals and Management Options. The scientific basis for, and recommended revisions to, the goals proposed in the Action Plan; and the scientific basis for the efficacy of recommended management actions to reduce nutrient flux from point and nonpoint sources. In addressing the state of the science, the book focuses on the strengths and limitations of the science in managing the Gulf hypoxia problem, including available data, models and model results and uncertainty. It includes work from the following authors: C. Kling, Iowa State University, Ames, IA, USA; J.L. Meyer, University of Georgia, Athens, GA, USA; J. Sanders, Skidaway Institute of Oceanography, Savannah, GA, USA; H. Stallworth, Environmental Protection Agency, Washington D.C., USA; T. Armitage, Environmental Protection Agency,Washington, D.C., USA; D. Wangsness, U.S. Geological Survey, Atlanta, GA, USA; T.S. Bianchi, Texas A&M University, College Station, TX, USA; A. Blumberg, Stevens Institute of Technology, Hoboken, NJ, USA; W. Boynton, University of Maryland, MD, USA; D.J. Conley, Lund University, Lund, Sweden; W. Crumpton, Iowa State University, Ames, IA, USA; M.B. David, University of Illinois, Urbana, IL, USA; D. Gilbert, Maurice-Lamontagne Institute, Mont-Joli, Quebec, Canada; R.W. Howarth, Cornell University, Ithaca, NY, USA; R. Lowrance, Agricultural Research Service, USDA, Tifton, GA, USA; K. Mankin, Kansas State University, Manhattan, KS, USA; J. Opaluch, University of Rhode Island, Kingston, RI, USA; H. Paerl, University of North Carolina, Chapel Hill, Morehead City, NC, USA; K. Reckhow, Duke University, Durham, NC, USA; A.N. Sharpley, University of Arkansas, Fayetteville, AR, USA; T.W. Simpson, University of Maryland, College Park, MD, USA; C. Snyder, International Plant Nutrition Institute,USA; Conway, AR; D. Wright, College of William and Mary, Gloucester Point, VA, USA.
Hypsodonty in Mammals
by Richard H. MaddenThe evolution of high-crowned teeth, hypsodonty, is a defining characteristic of many terrestrial herbivores. To date, the most prominent focus in the study of the teeth of grazing herbivores has been co-evolution with grasses and grasslands. This book develops the idea further and looks at the myriad ways that soil can enter the diet. Madden then expands this analysis to examine the earth surface processes that mobilize sediment in the environment. The text delivers a global perspective on tooth wear and soil erosion, with examples from the islands of New Zealand to the South American Andes, highlighting how similar geological processes worldwide result in convergent evolution. The final chapter includes a review of elodonty in the fossil record and its environmental consequences. Offering new insights into geomorphology and adaptive and evolutionary morphology, this text will be of value to any researcher interested in the evolution of tooth size and shape.
Hyrdogen Storage and Technologies (Advances in Hydrogen Production and Storage (AHPS))
by Mehmet Sankir Nurdan Demirci SankirHydrogen storage is considered a key technology for stationary and portable power generation especially for transportation. This volume covers the novel technologies to efficiently store and distribute hydrogen and discusses the underlying basics as well as the advanced details in hydrogen storage technologies. The book has two major parts: Chemical and electrochemical hydrogen storage and Carbon-based materials for hydrogen storage. The following subjects are detaled in Part I:• Multi stage compression system based on metal hydrides; • Metal-N-H systems and their physico-chemical properties; • Mg-based nano materials with enhanced sorption kinetics;• Gaseous and electrochemical hydrogen storage in the Ti-Z-Ni; • Electrochemical methods for hydrogenation/dehydrogenation of metal hydrides. In Part II the following subjects are addressed: • Activated carbon for hydrogen storage obtained from agro-industrial waste;• Hydrogen storage using carbonaceous materials; • Hydrogen storage performance of composite material consisting of single walled carbon nanotubes and metal oxide nanoparticles; • Hydrogen storage characteristics of graphene addition of hydrogen storage materials; • Discussion of the crucial features of hydrogen adsorption of nanotextured carbon-based materials.
Hysteresis Phenomena in Biology
by Hamid Reza NooriThe occurrence of hysteresis phenomena has been traditionally associated with mechanical and magnetic properties of materials. However, recent studies on the dynamics of biological processes suggest switch-like behavior that could be described by mathematical models of hysteresis. This book presents the milestones and perspectives of biological hysteresis and provides a comprehensive and application-oriented introduction to this subject. The target audience primarily comprises researchers but the book may also be beneficial for graduate students.
The I-5 Killer
by Ann RuleThe terrifying true crime story of the I-5 serial killer from Ann Rule, the #1 New York Times bestselling author of The Stranger Beside Me. Randall Woodfield had it all. He was an award-winning student and star athlete. he was drafted for pro football by the Green Bay Packers, and chosen by Playgirl as a centerfold candidate. Working in the swinging West Coast bar scene, he had his pick of willing sexual prospects. But Randall Woodfield wanted more than just sex. An appetite for unspeakable violent acts led him to cruise the I-5 highway through California, Oregon, and Washington, leaving a trail of victims along the way. As the list of his victims grew to a total of at least 44, the police faced the awesome challenge of catching and convicting a suspect who seemed to handsome and appealing to have committed such ugly crimes—crimes that filled every woman within his striking range with feat and horror....
I am Albert Einstein (Ordinary People Change The World)
by Brad MeltzerEven when he was a kid, Albert Einstein did things his own way. He thought in pictures instead of words, and his special way of thinking helped him understand big ideas like the structure of music and why a compass always points north. Those ideas made him want to keep figuring out the secrets of the universe. Other people thought he was just a dreamer, but because of his curiosity, Einstein grew up to be one of the greatest scientists the world has ever known. <p><p> What makes a hero? This lively, fun biography series by best-selling author Brad Meltzer answers the question, one great role model at a time.
I am Albert Einstein (Ordinary People Change the World)
by Brad Meltzer"We can all be heroes" is the message entertainingly told in this New York Times Bestselling picture-book biography series, with this one highlighting Albert Einstein (Cover may vary)Each picture book in this series is a biography of a significant historical figure, told in a simple, conversational, vivacious way, and always focusing on a character trait that made the person heroic. The heros are depicted as children throughout, telling their life stories in first-person present tense, which keeps the books playful and accessible to young children. And each book ends with a line of encouragement, a direct quote, and photos on the last page. This biography focuses on Albert Einstein's never-ending curiosity and how it helped him be a better scientist. This friendly, fun biography series inspired the PBS Kids TV show Xavier Riddle and the Secret Museum. One great role model at a time, these books encourage kids to dream big. Included in each book are: • A timeline of key events in the hero&’s history • Photos that bring the story more fully to life • Comic-book-style illustrations that are irresistibly adorable • Childhood moments that influenced the hero • Facts that make great conversation-starters • A virtue this person embodies: Albert Einstein's curiosity led him to become a world-renowned scientist. You&’ll want to collect each book in this dynamic, informative series!
I am Amelia Earhart (Ordinary People Change the World)
by Brad MeltzerGroundbreaking American pilot Amelia Earhart is the 2nd hero in the New York Times bestselling picture book biography series for ages 5 to 8. (Cover may vary) Amelia Earhart refused to accept no for an answer; she dared to do what no one had ever done before, and became the first woman to fly a plane all the way across the Atlantic Ocean. This biography follows her from childhood to her first flying lessons and onward to her multi-record-breaking career as a pilot. This friendly, fun biography series inspired the PBS Kids TV show Xavier Riddle and the Secret Museum. One great role model at a time, these books encourage kids to dream big. Included in each book are: • A timeline of key events in the hero&’s history • Photos that bring the story more fully to life • Comic-book-style illustrations that are irresistibly adorable • Childhood moments that influenced the hero • Facts that make great conversation-starters • A character trait that made the person heroic and that readers can aspire to You&’ll want to collect each book in this dynamic, informative series!
I am Benjamin Franklin (Ordinary People Change the World)
by Brad MeltzerThe 21st book in the New York Times bestselling series of biographies about heroes tells the story of Benjamin Franklin, one of the Founding Fathers of the U.S. who helped draft the Declaration of Independence while making important scientific contributions. (Cover may vary) This friendly, fun biography series focuses on the traits that made our heroes great--the traits that kids can aspire to in order to live heroically themselves. Each book tells the story of an icon in a lively, conversational way that works well for the youngest nonfiction readers and that always includes the hero's childhood influences. At the back are an excellent timeline and photos.Driven by his curiosity from a young age, Benjamin Franklin's observations about the world led to key discoveries about electricity and other contributions that remain important today.This friendly, fun biography series inspired the PBS Kids TV show Xavier Riddle and the Secret Museum. One great role model at a time, these books encourage kids to dream big. Included in each book are: • A timeline of key events in the hero&’s history • Photos that bring the story more fully to life • Comic-book-style illustrations that are irresistibly adorable • Childhood moments that influenced the hero • Facts that make great conversation-starters • A virtue this person embodies: Benjamin Franklin's commitment to self-improvement is the highlight of this biography You&’ll want to collect each book in this dynamic, informative series!
I am Curious: A Little Book About Albert Einstein (Ordinary People Change the World)
by Brad MeltzerThe littlest readers can learn about Albert Einstein in this board book version of the New York Times bestselling Ordinary People Change the World biography.This friendly, fun biography series focuses on the traits that made our heroes great--the traits that kids can aspire to in order to live heroically themselves. In this new board book format, the very youngest readers can learn about an icon in the series's signature lively, conversational way. The short text focuses on drawing inspiration from these iconic heroes, and includes an interactive element and factual tidbits that young kids will be able to connect with. This volume tells the story of Albert Einstein, one of the world's greatest scientists.
I Am Destroying The Land!: The Political Ecology Of Poverty And Environmental Destruction In Honduras
by Susan C StonichThis book is about interconnections-those among the historical, geographic, demographic, social, economic, and ecological aspects of development-as well as how Central Americans struggle with the interplay of increasing poverty and environmental degradation. Centering on the case of southern Honduras and expanding to include the Central American region, Susan Stonich's analysis employs an integrative approach that builds on a strong and varied methodological foundation to encompass both political economy and ecology. Stonich examines the systemic linkages among the dynamics of dominant development models and associated patterns of capitalist accumulation, regional demography, rural impoverishment, and environmental decline. By casting the discussion against the backdrop of southern Honduras, she presents a powerful historical record of how larger socio-political communities impact individuals and the natural environment and how, in turn, people respond. She charts the destiny of peasant groups within the dynamics of contemporary capitalism, recognizing that the fates of the peasantry and the natural environment are intimately linked. Stonich's study contributes to an improved understanding of the complex interrelationships between social processes and environmental degradation, offering a timely and pertinent comment on one of the most serious modern challenges
I Am George Washington Carver (Xavier Riddle and the Secret Museum)
by Brooke VitaleAn 8x8 based on an episode from the PBS KIDS animated television series Xavier Riddle and the Secret Museum starring George Washington Carver.Based on the children's book series ORDINARY PEOPLE CHANGE THE WORLD by New York Times bestselling author Brad Meltzer and illustrator Christopher Eliopoulos, the series will introduce kids to inspiring historical figures and the character virtues that helped them succeed.With the help of inventor, painter, musician, and botanist George Washington Carver, Brad, Xavier, and Yadina come together to learn how to take care of the Earth. This episode-based 8x8 will focus on the traits that made our heroes great--the traits that kids can aspire to in order to live heroically themselves.
I am I. M. Pei (Ordinary People Change the World)
by Brad MeltzerThe world-renowned architect I. M. Pei is the twenty-fourth hero in the New York Times bestselling picture book biography series. (Cover may vary)This friendly, fun biography series focuses on the traits that made our heroes great--the traits that kids can aspire to in order to live heroically themselves. Each book tells the story of an icon in a lively, conversational way that works well for the youngest nonfiction readers and that always includes the hero's childhood influences. At the back are an excellent timeline and photos. This book features I. M. Pei, the award-winning Chinese American architect whose projects include the John F. Kennedy Library and the pyramid at the Louvre. Included is a pop-up of the Louvre to help young readers see the space and Pei's design in 3D!This friendly, fun biography series inspired the PBS Kids TV show Xavier Riddle and the Secret Museum. One great role model at a time, these books encourage kids to dream big. Included in each book are: • A timeline of key events in the hero&’s history • Photos that bring the story more fully to life • Comic-book-style illustrations that are irresistibly adorable • Childhood moments that influenced the hero • Facts that make great conversation-starters • A virtue this person embodies: I. M. Pei's ingenuity led him and his designs to brave new heights. You&’ll want to collect each book in this dynamic, informative series!