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Androgen Deficiency and Testosterone Replacement: Current Controversies and Strategies (Current Clinical Urology)
by Wayne J.G. HellstromAndrogen Deficiency and Testosterone Replacement: Current Controversies and Strategies explores the difficulties around the diagnosis and treatment of androgen deficiency. The text examines the available evidence concerning the diagnosis and treatment of men with low testosterone. It also examines controversies in the identification and management of these men. While the information contained within will be of use to those who specialize in androgen deficiency and sexual medicine, the scope of the book will serve as a source of basic information about testosterone replacement and as a source of reasoned analysis of the controversies surrounding testosterone replacement in the aging male. Physicians and physician extenders will be able to apply evidence management principles to the evaluation and treatment of men with testosterone deficiency; supported by the most recent practice guidelines available. The authors represent a select group of physicians with expertise in androgen deficiency and replacement. Androgen Deficiency and Testosterone Replacement: Current Controversies and Strategies will be of great value to all physicians and physician extenders who deliver health care to men of all ages.
Androgen-Responsive Genes in Prostate Cancer: Regulation, Function and Clinical Applications
by Zhou WangAndrogens and androgen receptors (AR) play critical roles in the development and progression of prostate cancer, the most frequently diagnosed cancer and second leading cause of cancer death in US males. AR is an androgen-dependent DNA-binding transcription factor that regulates the expression of androgen-responsive genes. Identification and characterization of androgen-responsive genes provide insights into the cellular mechanisms of androgen action and may lead to new approaches in diagnosis, prognosis, prevention and/or treatment of prostate cancer. This volume provides critical information from well respected experts in the field. Some of the exciting topics include the new understanding of mechanisms underlining the regulation of androgen-responsive gene expression, and functions of various androgen-responsive genes in biological processes essential in carcinogenesis including cell growth, angiogenesis, and epithelial-to-mesenchyme transition (EMT). Other important aspects addressed are the current and potential clinic applications of knowledge on androgen-responsive gene regulation and function. This book is intended for researchers, scientists, faculty, and advanced graduate students with an interest in androgen action and prostate cancer.
Androgens in Gynecological Practice
by Leo PlouffeA practical approach to the field of androgen excess or deprivation in women's health. The content includes multiple viewpoints on the most common disorders in this class, such as polycystic ovary disease, hirsutism and menopausal issues. Each chapter provides a combination of long-lasting clinical principles in the diagnosis and management of these patients along with a state-of-the-art review. This text takes an innovative approach to uncommon conditions (such as congenital adrenal hyperplasia, transgender conditions). In addition to presenting clinical insights, and a review of the basic science underpinning these conditions, it focuses on key concepts that can be derived from these rare conditions to the entire field. This book is an essential addition to the library for any busy clinician who is looking for a practical reference guide but also for the sub-specialist who is looking for new and thought-provoking insights in this complex scientific area.
Android Malware and Analysis
by Ken Dunham Shane Hartman Manu Quintans Jose Andre Morales Tim StrazzereThe rapid growth and development of Android-based devices has resulted in a wealth of sensitive information on mobile devices that offer minimal malware protection. This has created an immediate need for security professionals that understand how to best approach the subject of Android malware threats and analysis.In Android Malware and Analysis, K
The Andromeda Galaxy and the Rise of Modern Astronomy
by David SchultzThe Andromeda Galaxy - Messier's M31 - has an almost romantic appeal. It is the most distant object and the only extragalactic object that is visible to the unaided human eye. Now known to be about 2½ million light-years away, it appears in the sky to be several times the width of the full Moon under good seeing conditions. The Andromeda Galaxy and the Rise of Modern Astronomy examines the astronomical studies of Andromeda and its importance to our developing knowledge of the universe. The book discusses how M31 was described both by the Ancients, but more importantly, by astronomers from the nineteenth century to the present. While at the start of the twentieth century the universe was thought of as a finite cosmos dominated by the Milky Way, the study of Andromeda galaxy shattered that image, leading ultimately to the conception of an infinite universe of countless galaxies and vast distances. Even today, M31 is a major focal point for new astronomical discoveries, and it also remains one of the most popular (and rewarding) celestial objects for amateur astronomers to observe and study. This book reveals the little-known history of M31 and the scientists who study it. For all who are interested in astronomy, the skies, and perhaps even the origins of the universe, The Andromeda Galaxy and the Rise of Modern Astronomy provides a first-of-its-kind accessible, informative, and highly readable account of how the study and observation of this celestial object has driven the development of astronomy from ancient times to the present.
Anechoic and Reverberation Chambers: Theory, Design, and Measurements (Wiley - IEEE)
by Qian Xu Yi HuangA comprehensive review of the recent advances in anechoic chamber and reverberation chamber designs and measurements Anechoic and Reverberation Chambers is a guide to the latest systematic solutions for designing anechoic chambers that rely on state-of-the-art computational electromagnetic algorithms. This essential resource contains a theoretical and practical understanding for electromagnetic compatibility and antenna testing. The solutions outlined optimise chamber performance in the structure, absorber layout and antenna positions whilst minimising the overall cost. The anechoic chamber designs are verified by measurement results from Microwave Vision Group that validate the accuracy of the solution. Anechoic and Reverberation Chambers fills this gap in the literature by providing a comprehensive reference to electromagnetic measurements, applications and over-the-air tests inside chambers. The expert contributors offer a summary of the latest developments in anechoic and reverberation chambers to help scientists and engineers apply the most recent technologies in the field. In addition, the book contains a comparison between reverberation and anechoic chambers and identifies their strengths and weaknesses. This important resource: • Provides a systematic solution for anechoic chamber design by using state-of-the-art computational electromagnetic algorithms • Examines both types of chamber in use: comparing and contrasting the advantages and disadvantages of each • Reviews typical over-the-air measurements and new applications in reverberation chambers • Offers a timely and complete reference written by authors working at the cutting edge of the technology • Contains helpful illustrations, photographs, practical examples and comparison between measurements and simulations Written for both academics and industrial engineers and designers, Anechoic and Reverberation Chambers explores the most recent advances in anechoic chamber and reverberation chamber designs and measurements.
Anesthesia and Perioperative Care for Aortic Surgery
by Balachundhar Subramaniam Kathirvel Subramaniam Kyung W. ParkThis book is the first of its kind - a comprehensive reference for anesthesia and perioperative clinicians involved in aortic surgery. With a primary focus on anesthesia for various aortic surgical procedures, including endovascular aortic surgery, the title also provides expanded coverage of CNS monitoring and protection, intraoperative transesophageal echocardiography, renal and spinal cord protection during surgery, management of aortic trauma, and postoperative care. Written by top cardiac anesthesiologists, surgeons, and intensivists, this indispensable reference provides everything you need to know about the burgeoning field of aortic surgery in one handy volume.
Anesthesiology and Otolaryngology
by Adam I. Levine Samuel Demaria Jr. Satish GovindarajTo an unusual degree, the shared "working space" of otolaryngologists and anesthesiologists means that issues important to one are important to the other. Anesthesiology and Otolaryngology is the first book to address the closely overlapping information needs of both groups of specialists. It is collaboratively written and edited by anesthesiologists and otolaryngologists, and the chapters are carefully designed to insure maximal relevance to members of both specialties. The heart of the book consists of chapters on managing patients during the full range of otolaryngologic procedures. These chapters are structured chronologically, and otolaryngologic and anesthesiologic perspectives are systematically presented for each operative stage. Foundational topics such as gross and radiographic anatomy, physiology, and pharmacology are covered. The book includes a unique chapter on oxygen delivery systems that serves as a comprehensive review for anesthesiologists and an overview for the otolaryngologist. Special topics addressed include acute and chronic pain management, and the logistics of managing an office-based surgical practice. · "All-in-one" reference for otolaryngologists and otolaryngologic anesthesiologists · Surgical and anesthesiologic perspectives marshaled for pre-operative, intraoperative, and postoperative periods · Pearls and Insights at end of chapters · Organized by surgical region · Special challenges of difficult airway and of pediatric otolaryngologic procedures addressed
Anesthetic Toxicity
by Susan A. Rice Kevin J. FishThis text is a source of information on the toxicity of anaesthetic agents. The editors define toxicity in a broad sense to mean an adverse effect, whether that effect is the result of pharmacological, toxicological, physiological, or other mechanisms. They bring together reviews by experts in the disciplines concerned - including biochemistry, gen
Aneurysms of the Popliteal Artery
by Antonino CavallaroPopliteal aneurysms are still controversial in terms of their pathogenesis, and challenging in terms of their treatment. This book offers a detailed overview of the latest advances in our understanding of the disease, and highlights the latest theories. Divided into eght sections, it focuses on: the historical background, embryology and anatomy of the popliteal artery, clinical presentation and diagnosis, pros and cons of traditional surgical techniques, pros and cons of advanced endovascuar techniques. The last section focuses on non-atherosclerotic popliteal aneurysme, i.e. on diseases in which popliteal aneurysms may specifically appear, rendering more challenging the diagnosis and the treatment As stressed in the foreword by the Chief Editor of the Journal of Vascuar Surgery, this book, given its scope, offers a valuable guide for all health professionals - experts and in training -.involved in vascular pathology and surgery.
The Angel and the Assassin: The Tiny Brain Cell That Changed the Course of Medicine
by Donna Jackson NakazawaA thrilling story of scientific detective work and medical potential that illuminates the newly understood role of microglia—an elusive type of brain cell that is vitally relevant to our everyday lives. &“The rarest of books: a combination of page-turning discovery and remarkably readable science journalism.&”—Mark Hyman, MD, #1 New York Times bestselling author of Food: What the Heck Should I Eat? Until recently, microglia were thought to be merely the brain&’s housekeepers, helpfully removing damaged cells. But a recent groundbreaking discovery revealed them to be capable of terrifying Jekyll and Hyde behavior. When triggered—and anything that stirs up the immune system in the body can activate microglia—they can morph into destroyers, impacting a wide range of issues from memory problems and anxiety to depression and Alzheimer&’s. Under the right circumstances, however, microglia can be coaxed back into being angelic healers, able to repair the brain in ways that help alleviate symptoms and hold the promise to one day prevent disease. A fascinating behind-the-scenes account of this cutting-edge science, The Angel and the Assassin also explores the medical implications of these game-changing discoveries. Award-winning journalist Donna Jackson Nakazawa began her investigation with a personal interest—when diagnosed with an autoimmune disorder years ago, she was convinced there was something physical going on in her brain as well as her body, though no doctor she consulted could explain how the two could be interacting in this way. With the compassion born of her own experience, she follows practitioners and patients on the front lines of treatments that help to &“reboot&” microglia—from neurofeedback and intermittent fasting to transcranial magnetic stimulation and gamma light flicker therapy. She witnesses patients finding significant relief from pressing symptoms—and at least one stunning recovery—offering new hope to the tens of millions who suffer from mental, cognitive, and physical health issues. Proving once and for all the biological basis for the mind-body connection, the discovery of the true role of microglia stands to rewrite psychiatric and medical texts as we know them. Hailed as &“riveting,&” &“stunning,&” and &“visionary,&” The Angel and the Assassin offers us a radically reconceived picture of human health and promises to change everything we thought we knew about how to heal ourselves.
Angelo Secchi and Nineteenth Century Science: The Multidisciplinary Contributions of a Pioneer and Innovator (Historical & Cultural Astronomy)
by Ileana Chinnici Guy ConsolmagnoAngelo Secchi was a key figure in 19th century science. An Italian Jesuit and scientist, he helped lead the transition from astronomy to astrophysics and left a lasting legacy in the field. Secchi’s spectral classification of stars was a milestone that paved the way for modern astronomical research. He was also a founder of modern meteorology and an innovator in the design and development of new instruments and methods across disciplines.This contributed volume collects together reviews from an international group of historians, scientists and scholars representing the multiple disciplines where Secchi made significant contributions during his remarkable career. It analyzes both his famous and lesser known pioneering efforts with equal vigor, providing a well-rounded narrative of his life’s work. Beyond his scientific and technological work, his role as a Jesuit priest in Rome during the turbulent years of the mid 19th century is also described and placed in the context of his scientific and civic activities.
Angewandte Bioinformatik: Eine Einführung
by Paul M. Selzer Oliver Koch Richard J. MarhöferF#65533;r Studierende und Wissenschaftler der Lebenswissenschaften schafft dieses Buch einen schnellen, strukturierten Zugang zur Angewandten Bioinformatik ohne Programmierkenntnisse oder tiefgehende Informatikkenntnisse vorauszusetzen. Es bietet eine Einf#65533;hrung in die t#65533;gliche Anwendung der vielf#65533;ltigen bioinformatischen Werkzeuge und gibt einen ersten #65533;berblick #65533;ber das sehr komplexe Fachgebiet. Die Kontrolle des vermittelten Stoffs wird durch #65533;bungsbeispiele mit L#65533;sungen gew#65533;hrleistet. Ein Glossar der zugrundeliegenden Fachtermini sowie ein ausf#65533;hrliches Sachverzeichnis runden das Buch ab. F#65533;r die 2. Auflage wurde das Werk umfassend aktualisiert.
Angewandte Bioverfahrensentwicklung: Praxisbeispiele für Auslegung, Betrieb und Kostenanalyse
by Winfried StorhasDie Biotechnologie liefert die Grundlagen für eine nachhaltige Herstellung von Produkten zur Versorgung der Weltbevölkerung mit Nahrungsmitteln, Medikamenten und anderen notwendigen Gütern. Um den weltweit steigenden Bedarf an biotechnologischen Prozessen zu realisieren, sind Ingenieurinnen und Ingenieure mit biotechnologischen Kenntnissen erforderlich. In diesem praxisnahen Buch werden Aufgaben aus den Bereichen Bioreaktoren, Bioreaktionstechnik, Steriltechnik, Scale-Up, Anlagenplanung- und betrieb, Investitions- und Kostenanalyse und Wirtschaftlichkeit exemplarisch gelöst und erlauben dem Leser eine einfache Nachvollziehbarkeit. Zahlreiche Referenzen geben dem Leser außerdem die Möglichkeit zur Vertiefung des erworbenen Wissens und diese Aufgabensammlung stellt damit die perfekte Ergänzung zum Standardwerk "Bioverfahrensentwicklung" von Professor Storhas dar. Neben einer integrierten Formelsammlung und einer kurzen, praxisorientierten Einführung umfasst das didaktische Konzept eine Einteilung der Aufgaben in unterschiedliche Typen, die exemplarisch und mit Hilfe von Kommentaren und Faustformeln aus der Praxis gelöst werden. Diese anwendungsbezogene Vertiefung in der Bioverfahrensentwicklung eignet sich besonders für Interessierte im Bereich der Bioverfahrenstechnik und verwandter Disziplinen, Studenten der Ingenieurs- und Naturwissenschaften sowie Verfahrenstechniker.
Angewandte Grundwasserchemie, Hydrogeologie und hydrogeochemische Modellierung: Grundlagen, Anwendungen und Problemlösungen
by Frank WisotzkyNeben den Anwendungen der Grundlagen der anorganischen Wasserchemie wird in dem Band erstmalig zusammenhängend die organische Wasserchemie von Grundwasserbelastungsstoffen behandelt. Darüber hinaus enthält er eine Einführung in die hydrochemische Modellierung und auch die chemischen Aspekte der Wasseraufbereitung werden dargestellt. Viele Beispiele aus der Praxis, Abbildungen und Schemazeichnungen machen die Grundwasserchemie nachvollziehbar und transparent. Mit zahlreichen Übungsaufgaben und dazugehörigen Lösungen.
Angewandte Grundwasserchemie, Hydrogeologie und hydrogeochemische Modellierung: Grundlagen, Anwendungen und Problemlösungen
by Frank Wisotzky Nils Cremer Stephan LenkNeben den Anwendungen der Grundlagen der anorganischen Wasserchemie wird in dem Band erstmalig zusammenhängend die organische Wasserchemie von Grundwasserbelastungsstoffen behandelt. Darüber hinaus enthält er eine Einführung in die hydrochemische Modellierung und auch die chemischen Aspekte der Wasseraufbereitung werden dargestellt. Viele Beispiele aus der Praxis, Abbildungen und Schemazeichnungen machen die Grundwasserchemie nachvollziehbar und transparent. Mit zahlreichen Übungsaufgaben und dazugehörigen Lösungen.
Angewandte Meteorologie: Mikrometeorologische Methoden
by Thomas FokenGegenstand des Buchs sind die atmosphärischen Vorgänge im Lebensraum des Menschen. Damit liefert es die Grundlagen insbesondere für die Biometeorologie, Agrarmeteorologie, Hydrometeorologie, Umweltmeteorologie und technische Meteorologie sowie für die Biogeochemie. Der Autor behandelt Theorie, Messtechnik, experimentelle Verfahren und Modellierung so, dass die Themen jeweils für sich stehen und die Inhalte einzeln in Lehre, Forschung und Praxis genutzt werden können. Für die Neuauflage wurden das Literaturverzeichnis und einzelne Kapitel erweitert.
Angewandte Statistik: Eine Einführung für Biologen und Mediziner
by Werner TimischlDie "Angewandte Statistik" ist ein Lehr- und Übungsbuch für Anwenderinnen und Anwender der Statistik, die ein Verständnis für statistische Methoden und eine Sicherheit in der Anwendung dieser Methoden erwerben wollen. Vorausgesetzt wird nur die Kenntnis der für den Universtäts- oder Fachhochschulzugang erforderlichen Schulmathematik. Das Lehrbuch führt zuerst in die Wahrscheinlichkeitsrechnung ein und stellt grundlegende Wahrscheinlichkeitsverteilungen vor. Ausführlich werden die Parameterschätzung und das Testen von Hypothesen behandelt. Mit den gängigen Korrelationsmaßen und ausgewählten Regressionsmodellen wird die statistische Grundbildung abgerundet. Die Kapitel über varianzanalytische Modelle und multivariate Verfahren geben einen Einblick in zwei weitere, für die statistische Praxis relevante Gebiete. Darüber hinaus werden Vertiefungen und spezielle Anwendungen in ergänzenden Abschnitten bereitgestellt. Zahlreiche, vollständig durchgerechnete Beispiele und Übungsaufgaben mit einem ausführlichen Lösungsteil machen die "Angewandte Statistik" zu einem Arbeitsbuch, das sich auch zum Selbststudium eignet. Die Ausrichtung auf die Statistik-Software R (durch Verweise auf die entsprechenden R-Funktionen und die Angabe des R-Codes bei den Lösungen der Aufgaben) trägt der Bedeutung computerunterstützter Problemlösungen in der statistischen Praxis Rechnung.
Angewandte Statistik in der Bewegungswissenschaft (Band 3)
by Kerstin WitteDieses Buch soll Studierende als auch Doktoranden motivieren, eigene Studien mit dem richtigen Untersuchungsdesign zu planen und durchzuführen.Für viele bewegungswissenschaftliche Untersuchungen müssen statistische Verfahren angewendet werden. Doch oft fällt es den Studierenden schwer, das jeweils geeignete Verfahren zu finden. Dieser Band soll helfen, insbesondere Studierenden der Sportwissenschaft zu helfen, die statistischen Grundlagen zu verstehen. Dabei unterstützt eine Vielzahl von Übersichten über die Verfahren und Abbildungen ihre Wirkungsweise. Viele sportmotorische Beispiele werden erläutert, um die Anwendbarkeit und den Praxisbezug zu demonstrieren. Zu den vertiefenden Aufgaben gibt es auch einen Abschnitt mit Hinweisen zur Lösung der in Band 2 gestellten empirischen Aufgaben.Auf folgende Themenschwerpunkte wird besonders eingegangen: empirische Forschungsmethoden, deskriptive Statistik, Wahrscheinlichkeitstheorie, Parameterschätzung, Aufstellen und Prüfen von Hypothesen, Verfahren zum Testen von Unterschieds- und Zusammenhangshypothesen, Varianzanalyse, Faktorenanalyse, Testtheorie und Zeitreihenanalyse.
Angewandte Statistik mit R für Agrarwissenschaften: Versuchsplanung und -auswertung mit konkreten Beispielen und Übungsaufgaben
by Dieter Rasch Rob VerdoorenDieses Buch führt in die angewandte Statistik für Agrarwissenschaften ein und unterstützt bei der Forschung in der Pflanzen- und Tierproduktion und im Feldversuchswesen. Es nutzt ausgiebig das frei verfügbare Programmpaket R: Über das gesamte Buch hinweg werden im Rahmen umfangreicher Beispiele passende R-Programmcodes angegeben und erläutert. Die Codes können mit eigenen Daten kombiniert und so zur Planung und Auswertung eigener Versuche verwendet werden. So können etwa Wachstumsfunktionen angepasst, Varianzanalysen berechnet oder optimale Versuchspläne und minimale Stichprobenumfänge gefunden werden und vieles mehr. Eine Installationsbeschreibung für R wird ebenfalls zur Verfügung gestellt. Zahlreiche Übungsaufgaben mit Lösungen ergänzen das Buch, so dass es als Lehr- und Nachschlagewerk nutzbar ist. Besonders hervorzuheben ist, dass auch balancierte unvollständige Blockanlagen (BUB) erläutert werden und erstmalig eine vollständige Liste kleinster (mit möglichst geringer Anzahl von Blocks) BUB für bis zu v = 25 Behandlungen und Blockgrößen ≤ v/2 im Netz zur Verfügung gestellt wird. Für Sortenversuche sind die BUB allerdings oft nicht nutzbar, weil sie zu viele Wiederholungen erfordern. Dafür haben sich „verallgemeinerte Gitter“ oder alpha-Anlagen bewährt, die ebenfalls behandelt werden.
Angiogenesis: Methods and Protocols (Methods in Molecular Biology #2441)
by Andrew V. BenestThis detailed book builds on the foundation of lymphatic protocols with tools to aid in the interpretation of large datasets created by angiogenesis research. For example, this includes protocols to explore how transcriptional phenotyping can be achieved, both in terms of exploring tissue-specific heterogeneity to the use of database mining of existing datasets. Similarly, bioinformatic techniques run alongside protocols for transcript analysis, cell biology, pathology, as well as physiological and developmental angiogenesis models. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Angiogenesis: Methods and Protocols provides a meaningful compendium of practical approaches to angiogenesis and endothelial cell biology research.
Angiogenesis: From Basic Science to Clinical Applications
by Napoleone FerraraWhy a new book on angiogenesis and why now? For the first time concepts proposed over 30 years ago have found clinical validation. In the last two years the first antiangiogenic agents have been approved by the FDA for the treatment of cancer and age-related macular degeneration. Not surprisingly, this clinical success has raised a new set of basic
Angiogenesis in Adipose Tissue
by Yihai CaoAngiogenesis has recently played a critical role in regulation of adipose tissue expansion and regression. Like most other tissues in the body, adipose expansion and regression is accompanied by alteration of blood vessel density and structures. The vascular alteration plays an active role in regulation of adipose tissue size and functions. Targeting blood vessels in the adipose tissue have demonstrated to be a novel approach for possibly treatment of cancer, obesity and other metabolic diseases. This book provides the most updated information on this type research and discusses future opportunities for therapy..
Angiogenesis in Health, Disease and Malignancy
by Ali SalajeghehThis book is about "Angiogenesis". A process in which new vasculature is formed from pre-existing capillaries. Angiogenesis process is associated with the proliferation and growth of both physiologically normal and neoplastic tissues, through the formation of vascular supply, essential for delivering growth requirements such as oxygen and nutrients. The book describes more than 100 genes and their key regulatory functions in the context of normal healthy condition, disease and malignancy, cancer proliferation and progression. New insights into the role of angiogenesis and the therapeutic inhibition of its regulators are investigated, due to the great potential for exploitation in the development of a novel treatment for cancer. New scientists, junior researchers and biomedical science students will find this book an invaluable introductory reference to their insight about angiogenesis and angiogenic role of more than 100 angiogenes and their role in healthy, disease and malignant conditions.
Angiogenesis Modulations in Health and Disease: Practical Applications of Pro- and Anti-angiogenesis Targets
by Shaker A. Mousa Paul J. DavisThis book is a major update of novel targets in angiogenesis modulation, including pro- and anti-angiogenesis. There is in-depth coverage of preclinical and clinical methods and models, investigational status, and clinical applications. The impact of nanotechnology in advancing the applications of pro-and anti-angiogenesis strategies is also highlighted, along with stem cell and biotechnologies in research and development of angiogenesis modulating targets.