- Table View
- List View
Inertial Electrostatic Confinement (IEC) Fusion
by George H. Miley S. Krupakar MuraliThis book provides readers with an introductory understanding of Inertial Electrostatic Confinement (IEC), a type of fusion meant to retain plasma using an electrostatic field. IEC provides a unique approach for plasma confinement, as it offers a number of spin-off applications, such as a small neutron source for Neutron Activity Analysis (NAA), that all work towards creating fusion power. The IEC has been identified in recent times as an ideal fusion power unit because of its ability to burn aneutronic fuels like p-B11 as a result of its non-Maxwellian plasma dominated by beam-like ions. This type of fusion also takes place in a simple mechanical structure small in size, which also contributes to its viability as a source of power. This book posits that the ability to study the physics of IEC in very small volume plasmas makes it possible to rapidly investigate a design to create a power-producing device on a much larger scale. Along with this hypothesis the book also includes a conceptual experiment proposed for demonstrating breakeven conditions for using p-B11 in a hydrogen plasma simulation. This book also: Offers an in-depth look, from introductory basics to experimental simulation, of Inertial Electrostatic Confinement, an emerging method for generating fusion power Discusses how the Inertial Electrostatic Confinement method can be applied to other applications besides fusion through theoretical experiments in the text Details the study of the physics of Inertial Electrostatic Confinement in small-volume plasmas and suggests that their rapid reproduction could lead to the creation of a large-scale power-producing device Perfect for researchers and students working with nuclear fusion, Inertial Electrostatic Confinement (IEC) Fusion: Fundamentals and Applications also offers the current experimental status of IEC research, details supporting theories in the field and introduces other potential applications that stem from IEC.
The Inevitable Hour: A History of Caring for Dying Patients in America
by Emily K. AbelChanges in health care have dramatically altered the experience of dying in America.At the turn of the twentieth century, medicine’s imperative to cure disease increasingly took priority over the demand to relieve pain and suffering at the end of life. Filled with heartbreaking stories, The Inevitable Hour demonstrates that professional attention and resources gradually were diverted from dying patients. Emily K. Abel challenges three myths about health care and dying in America. First, that medicine has always sought authority over death and dying; second, that medicine superseded the role of families and spirituality at the end of life; and finally, that only with the advent of the high-tech hospital did an institutional death become dehumanized. Abel shows that hospitals resisted accepting dying patients and often worked hard to move them elsewhere. Poor, terminally ill patients, for example, were shipped from Bellevue Hospital in open boats across the East River to Blackwell’s Island, where they died in hovels, mostly without medical care. Some terminal patients were not forced to leave, yet long before the advent of feeding tubes and respirators, dying in a hospital was a profoundly dehumanizing experience.With technological advances, passage of the Social Security Act, and enactment of Medicare and Medicaid, almshouses slowly disappeared and conditions for dying patients improved—though, as Abel argues, the prejudices and approaches of the past are still with us. The problems that plagued nineteenth-century almshouses can be found in many nursing homes today, where residents often receive substandard treatment. A frank portrayal of the medical care of dying people past and present, The Inevitable Hour helps to explain why a movement to restore dignity to the dying arose in the early 1970s and why its goals have been so difficult to achieve.
Inexcusabiles: Salvation and the Virtues of the Pagans in the Early Modern Period (International Archives of the History of Ideas Archives internationales d'histoire des idées #229)
by Alberto FrigoThis thought provoking book deals with religious scholarship and important controversies of the early modern period, specifically those relating to the question of the salvation of the pagans and the afterlife. From the Reformation, through the Renaissance and on to the seventeenth and eighteenth century, this was a time when religious scholarship was updated with the discoveries of the New World and colonial expansion. These chapters present new work, shedding light on the interplay of philosophy and theology in key thinkers such as Montaigne, Leibniz, Bayle and Spinoza, but also in less known authors such as Gianfrancesco Pico della Mirandola and Sebastian Castellio.Readers will discover analysis of the reshaping of specific theological issues, focussing on the reception of ancient philosophical traditions such as Platonism, Aristotelianism, Stoicism, Epicureanism, and scepticism. The authors investigate the relationship between the ethical models inspired by the heroes and philosophers of antiquity and the ‘new philosophy’. Above all, this book enables exploration of the ways in which discussions of the salvation and virtues of pagans intersected with the early modern reception of ancient philosophy, including a reassessment of the question of the moral status of unbelievers in the early modern period.Students and faculty working on early modern intellectual history will find that this book both inspires and enriches their knowledge. Those with an interest in Renaissance humanism, the history of early modern philosophy and science, in theology, or the history of religion will also appreciate the new contributions that it makes.
La infancia recuperada
by Fernando Savater«Este es un libro sobre libros: un libro sobre el amor a los libros y sobre la fuerza absorta de leer.»Fernando Savater La infancia recuperada es un conjuro literario para evocar la huella gozosa dejada en la memoria del escritor por los relatos que animaron su adolescencia y primera juventud. Un proyecto que Fernando Savater continuaría desarrollando más adelante en Criaturas del aire. Porque las hermosas historias inventadas por Robert L. Stevenson, Julio Verne, Zane Grey, Jack London, H.G. Wells, Karl May y Conan Doyle, las heroicas hazañas de Sandokan o las divertidas aventuras de Guillermo Brown forman parte de un universo mítico situado por encima de las modas y de las edades. En el prólogo que escribiera en su día para la edición de bolsillo (aparecida diez años después de su publicación original), Fernando Savater explica los motivos que le impulsaron a escribir esta obra «sobre el amor a los libros y sobre la fuerza absorta de leer» y aclara algunos malentendidos en torno a sus propósitos. «Es descabellado suponer que mientras haya gente afectada por esta maldición del ansia insaciable de cuentos, incapaces de considerar la sabiduría o el amor fuera del prisma de lo narrativo, inútiles para otra perspectiva de la acción que no sea el punto de vista del héroe, es descabellado suponer que mientras haya enfermos incurables del mito, como lo soy yo, las historias perdurarán aunque se hunda la literatura y la cultura toda que conocemos?»Fernando Savater
The Infancy of Atomic Physics: Hercules in His Cradle
by Alex KellerAtomic physics is a mighty Hercules that dominates modern civilization, promising immense reserves of power but threatening catastrophic war and radioactive pollution. The story of the atom's discovery and the development of techniques to harness its energy offers fascinating insights into the forces behind twenty-first-century technology. This compelling history portrays the human faces and lives behind the beginnings of atomic science.The Infancy of Atomic Physics ranges from experiments in the 1880s by William Crookes and others to the era just after the First World War, when Rutherford's first speculations on the structures of the atomic nucleus led to the discovery of the neutron -- and thus to nuclear weapons and nuclear power. It describes the dramatic researches as they were made, and it shows how they were interpreted in the scientific language of their time. This survey not only depicts the impressions of leading scientists like Thomson, Rutherford, Einstein, and Bohr, but it also reflects the views of ordinary laboratory scientists as well as the ways in which innovations were introduced to the wider public.
The Infancy of Speech and the Speech of Infancy (Psychology Library Editions: Speech and Language Disorders)
by Leopold SteinFor many centuries scientists and philosophers have endeavoured to solve the baffling problem of human language. Originally published in 1949, Dr Stein had been fascinated by this problem and collected an enormous amount of data from past and present ages which, when viewed together, shed light upon the origin, evolution and meaning of human speech. He adheres to the broad concept that the development of the individual is a brief recapitulation of the evolution of the race, and has attempted to apply this principle to the solution of the problem of language. For this purpose, he has delved into the realms of prehistory, history, comparative philology, anatomy, physiology and psychology and has made conjectures from his data as to the prehistoric patterns of human speech. Where direct evidence is lacking he has resorted boldly to analogy and fantasy. The result is an intriguing mosaic which should prove interesting to all those concerned with the promotion of human relations which are, to a great extent, dependent on communication through speech. The work is crowned by the fact that his assumptions were being verified by the promising results obtained in the treatment of speech disorders based upon them at the time.
Infant and Toddler Care and Development
by Amanda TaintorWhen you think about infants and toddlers, what words and images come to mind? William James imagined infants as experiencing a “blooming, buzzing confusion” (James, 1890). More recent and more accurate images consider infants and toddlers as young scientists making sense of their world as they actively engage with it (Gopnik, 2012; Gopnik, Meltzoff & Kuhl, 1999). The goal of this section is to briefly introduce you to infants and toddlers by presenting demographic information, guiding principles of infant/toddler care and education and to demonstrate why quality care and education for infants and toddlers is so important.
The Infant Mind
by Marc H. Bornstein David W. Haley Maria LegersteeIntegrating cutting-edge research from multiple disciplines, this book provides a dynamic and holistic picture of the developing infant mind. Contributors explore the transactions among genes, the brain, and the environment in the earliest years of life. The volume probes the neural correlates of core sensory, perceptual, cognitive, emotional, and social capacities. It highlights the importance of early relationships, presenting compelling findings on how parent-infant interactions influence neural processing and brain maturation. Innovative research methods are discussed, including applications of behavioral, hormonal, genetic, and brain imaging technologies.
Infanticide: Comparative and Evolutionary Perspectives
by Glenn Hausfater Sarah Blaffer HrdyRecent field studies of a variety of mammalian species reveal a surprisingly high frequency of infanticide - the killing of unweaned or otherwise maternally dependent offspring. Similarly, studies of birds, fish, amphibians, and invertebrates demonstrate egg and larval mortality in these species, a phenomenon directly analogous to infanticide in mammals. In this collection, Hausfater and Hrdy draw together work on animal and human infanticide and place these studies in a broad evolutionary and comparative perspective.Infanticide presents the theoretical background and taxonomic distribution of infanticide, infanticide in nonhuman primates, infanticide in rodents, and infanticide in humans. It examines closely sex allocation and sex ratio theory, surveys the phylogeny of mammalian interbirth intervals, and reviews data on sources of egg and larval mortality in a variety of invertebrate and lower vertebrate species. Dealing with infanticide in nonhuman primates, two chapters critically examine data on infanticide in langurs and its broader theoretical implications. By reviewing sources of infant mortality in populations of small mammals and new laboratory analyses of the causes and consequences of infanticide, this work explores such issues as the ontogeny of infanticide, proximate cues of infants and females which elicit infanticidal behavior in males, the genetical basis of infanticide, and the hormonal determinants.Hausfater and Sarah Blaffer Hrdy, through their selection of materials for this book, evaluate the frequency, causes, and function of infanticide. Historical, ethnographic, and recent data on infanticide are surveyed. "Infanticide" summarizes current research on the evolutionary origins and proximate causation of infanticide in animals and man. As such it will be indispensable reading for anthropologists and behavioral biologists as well as ecologists, psychologists, demographers, and epidemiologists.
Infanticide And Parental Care
by Stefano Parmigiani Frederick S. vom SaalFirst published in 1994. Routledge is an imprint of Taylor & Francis, an informa company.
Infantry Small Arms of the 21st Century: Guns of the World's Armies
by Leigh NevilleThe author of Guns of the Special Forces 2001-2015 presents a comprehensive overview of 21st century military guns used by small armies around the world. Soldiers in today's modern armies have access to ever more advanced infantry weapons; lighter, more compact and more accurate than anything seen in the last century. These include combat pistols, personal assault rifles, submachine guns, sniper rifles, shotguns, light machine guns and squad automatic weapons. Infantry Small Arms of the 21st Century features all these weapons and more, examining each in exhaustive detail. The author draws on the operational combat experience of the users in war zones such as Iraq, Afghanistan and Ukraine. As well as assessing and comparing the potency of different nations weapon systems, the book looks to the future demands of the infantry man.
Infantry Small Arms of the 21st Century: Guns of the World's Armies
by Leigh NevilleThe author of Guns of the Special Forces 2001-2015 presents a comprehensive overview of 21st century military guns used by small armies around the world. Soldiers in today's modern armies have access to ever more advanced infantry weapons; lighter, more compact and more accurate than anything seen in the last century. These include combat pistols, personal assault rifles, submachine guns, sniper rifles, shotguns, light machine guns and squad automatic weapons. Infantry Small Arms of the 21st Century features all these weapons and more, examining each in exhaustive detail. The author draws on the operational combat experience of the users in war zones such as Iraq, Afghanistan and Ukraine. As well as assessing and comparing the potency of different nations weapon systems, the book looks to the future demands of the infantry man.
Infection and Immunity (Lifelines Series)
by D H Davies M A Halablab T W Young F. E. Cox J. ClarkeThis concise text explores the interactions between pathogens and the immune system. Taking a disease-based approach, it explains how micro-organisms adapted to growth in human hosts can evade the immune system and cause disease.The opening chapter overviews the innate and adaptive immune responses to microbes. Subsequent chapters are specific
Infection, Immune Homeostasis and Immune Privilege
by Joan Stein-StreileinOrgans and tissues that can tolerate little or no inflammation have developed multiple overlapping mechanisms of immune protection in the absence of inflammation. These areas have been designated "immune-privileged sites" by Peter Medawar and include the central nervous system, eye, reproductive tract, testis and possibly the liver. Mechanisms of immune homeostasis found in less immune-regulated organs are often evident in the immune privileged sites and vice versa. It is important that the non-inflammatory mechanisms that contribute to immune privilege allow host defense against infectious organisms. This volume highlights the mechanisms leading to immune privilege in tissues and organs, the deviation of immune responses and the modification of the behavior of the immune cells that manage to cross the blood barriers of tissues, in the context of infection.
Infectious: Pathogens and How We Fight Them
by Dr John TregoningNature wants you dead. Not just you, but your children and everyone you have ever met and everyone they have ever met; in fact, everyone. It wants you to cough and sneeze and poop yourself into an early grave. It wants your blood vessels to burst and pustules to explode all over your body. And – until recently – it was really good at doing this… Covid-19 may be only the first of many modern pandemics. The subject of infection and how to fight it grows more urgent every day. How do pathogens cause disease? And what tools can we give our bodies to do battle? Dr John S. Tregoning has dedicated his career to answering these questions. Infectious uncovers fascinating success stories in immunology and virology, making this book not only a vital overview of infection, but also a hopeful story of ongoing human ingenuity.
Infectious: Pathogens and How We Fight Them
by Dr John S. Tregoning&‘This book catapults us to the frontier of the vital science of infections and immune responses. Tregoning is a perfect guide, writing with wit and intelligence about a subject which surely everyone feels the importance of now. Brilliant and right on the zeitgeist.&’Daniel M. Davis, author of The Beautiful Cure and The Secret Body &‘Packed with fascinating facts, intriguing anecdotes and more than a few Dad jokes, Infectious is an expertly guided, pacey tour through the world of all the stuff that&’s trying to kill us and how our immune systems and human ingenuity are fighting back.&’Dr Kat Arney, science communicator and author of Rebel Cell: Cancer, Evolution and the Science of Life Nature wants you dead. Not just you, but your children and everyone you have ever met and everyone they have ever met; in fact, everyone. It wants you to cough and sneeze and poop yourself into an early grave. It wants your blood vessels to burst and pustules to explode all over your body. And – until recently – it was really good at doing this… COVID-19 may be only the first of many modern pandemics. The subject of infection and how to fight it grows more urgent every day. How do pathogens cause disease? And what tools can we give our bodies to do battle? Dr John S. Tregoning has dedicated his career to answering these questions. Infectious uncovers fascinating success stories in immunology and virology, making this book not only a vital overview of infection, but also a hopeful story of ongoing human ingenuity.
Infectious Agents and Cancer
by Anton G. Kutikhin Elena B. Brusina Arseniy E. YuzhalinOver the years of cancer investigation a lot of discoveries in this field were made, and many associations between various biological carcinogens and cancer were revealed. Some of them are credibly determined, thus these infectious agents (human papilloma virus, hepatitis B virus, hepatitis C virus, Epstein-Barr virus, human herpes virus 8, human T-cell lymphotropic virus 1, human immunodeficiency virus, Merkel cell polyomavirus, Helicobacter pylori, Opisthorchis viverrini, Clonorchis sinensis, Schistosoma haematobium) are recognized as carcinogens and probable carcinogens by International Agency for Research on Cancer (IARC). The problem is of large importance, since share of infectious agents-related cancer cases is steadily increasing, reaching 25% according to certain estimates. It is worth noting that many of cancer cases are caused by infectious agents other than «conventional ones» like HPV, EBV, HBV, HCV, H.pylori etc. In recent years, a number of significant breakthroughs in the field were performed, such as the discovery of the microbiota role in cancer causation.
Infectious and Medical Waste Management
by Peter A. ReinhardtThis complete guide to infectious and medical waste management is required reading for everyone who handles, treats, transports, disposes of, or is responsible for this waste. Until now, no book has been written that explains in detail how to safely comply with the complex regulations and how to set up an effective infectious and medical waste program (including AIDS and Hepatitis B viruses) so the right decisions can be made. This valuable book gives you the expertise of the authors' combined 30 years' experience with this vital topic. Organized and presented in a clear, concise style-complete and practical-Infectious and Medical Waste Management covers every major and minor topic in this field: Medical Waste, Infectious Waste, Chemical Waste, and Radioactive Waste-everything you need to know is thoroughly covered. Presents waste audit plan organized by: collection, containers, spills, storage and processing, transportation, treatment, disposal, personnel and management.
Infectious Disease Ecology: Effects of Ecosystems on Disease and of Disease On Ecosystems
by Richard S. Ostfeld Felicia Keesing Valerie T. EvinerGathering thirteen essays by forty leading experts who convened at the Cary Conference at the Institute of Ecosystem Studies in 2005, this book develops an integrated framework for understanding where these diseases come from, what ecological factors influence their impacts, and how they in turn influence ecosystem dynamics. It marks the first comprehensive and in-depth exploration of the rich and complex linkages between ecology and disease, and provides conceptual underpinnings to understand and ameliorate epidemics. It also sheds light on the roles that diseases play in ecosystems, bringing vital new insights to landscape management issues in particular. While the ecological context is a key piece of the puzzle, effective control and understanding of diseases requires the interaction of professionals in medicine, epidemiology, veterinary medicine, forestry, agriculture, and ecology. The essential resource on the subject, Infectious Disease Ecology seeks to bridge these fields with an ecological approach that focuses on systems thinking and complex interactions.
Infectious Disease Informatics
by Vitali SintchenkoThis book will be the first to leverage on recent breakthroughs in the rapid, high-throughput molecular profiling of pathogenic microorganisms, as well as text mining and the growing body of electronic sources of knowledge about the molecular epidemiology of pathogens with epidemic potential. The distinctive feature of this book is that its focus on bioinformatics enabled approaches to pathogen detection, investigation and management of infections. This volume also details new methods of analyzing the genetic and geographic data of pathogens to reconstruct their evolution and to identify the migration routes through which the strains spread regionally and internationally. This book will fill the existing gap in covering the bioinformatics aspects of infectious diseases and will complement numerous successful bioinformatics texts devoted to the mainstream of human genetics and cancer.
Infectious Diseases
by D. Jay Grimes Phyllis KankiInfectious Diseases: Selected Entries from the Encyclopedia of Sustainability Science and Technology presents authoritative, peer-reviewed contributions from leading experts on a wide range of major infectious diseases of global importance. Infectious diseases account for more than 17 million deaths each year worldwide. While modern medicine and technology have diminished the threat of many of these pathogens in high-income countries, the ever present threats of re-emerging infections, population mobility, natural disasters, and pathogen genetic variability are but some of the reasons for the dynamic threat of this broad category of risks to human health. An indispensable resource for students and scientists, the volume also covers some of the new technologies currently under development for infectious disease prevention, treatment, and eradication. The greater part of the infectious disease burden remains in the tropics, where low and middle-income countries lack the resources, infrastructure, and health systems to mount or sustain control efforts. Many contributions describe the efforts of the scientific research community and international donor agencies to achieve the integrated goals of vigilant surveillance, improved and cost-effective diagnostics, and treatment for sustainable disease control.
Infectious Diseases (Encyclopedia of Sustainability Science and Technology Series)
by Lester M. ShulmanThis volume on Infectious Diseases in an Encyclopedia of Sustainability Science and Technology (ESST) addresses the needs of health care providers and policy makers as well as scientists and engineers. Most of chapters in this volume deal with infectious diseases that directly affect humans, including the detailed characterization of specific pathogens, how they reproduce, how they are transmitted, and the means available to control, eliminate, or eradicate them. In this revised and updated second edition, the number of human infectious diseases covered has been significantly expanded. Other new chapters deal with current leading edge technologies for the diagnosis of pathogens; surveillance including environmental and syndromic surveillance for pathogens; requirements for quality assurance, quality control and the need for biological standards and controls to sustain high quality diagnosis and surveillance; the use of big data for personalized medicine; modeling infectious diseases; zoonotic and vector borne diseases; disease prevention with antibiotics, antivirals and vaccines; and factors that affect ecological balances leading to emergence of new diseases such as climate change and deforestation. Finally, infectious diseases that affect livestock and culture of plants for food, comfort and beauty are also addressed, since we must also consider them when discussing sustainability of humans in our ecosystem.
Infectious Diseases and Arthropods (Infectious Disease Ser.)
by Jerome GoddardWith the exception of a few tropical medicine schools worldwide, current medical education programs include almost zero discussion of the interface between infectious diseases and entomology. That is why this book was initially published in the first edition almost 17 years ago. The third edition of this valuable infectious disease entomology book updates all existing chapters with the newest scientific developments described in the medical and entomological literature in addition to covering 10 entirely new topics not addressed in previous editions, which include: · arthropod identification controversies · early beginnings of public health and disease control · red-meat allergy · updates on vaccine development for dengue and malaria · discussion of Chikungunya and Zika viruses · American Boutonnneuse Fever · the newest controversies in Lyme disease · recent findings of viruses in ticks · bed bug bite reactions · Morgellons disease (an imaginary infectious disease)
Infectious Diseases and Nanomedicine III: Second International Conference (icidn - 2015), Dec. 15-18, 2015, Kathmandu, Nepal (Advances in Experimental Medicine and Biology #1052)
by Santosh Thapa Rameshwar AdhikariThis book gathers selected peer-reviewed papers presented at the Second International Conference on Infectious Diseases and Nanomedicine (ICIDN), held in Kathmandu, Nepal on December 15–18, 2015. It also includes invited papers from the leading experts in the related fields. The book highlights the importance of “Interdisciplinary Collaborative Research for Innovation in the Biomedical Sciences,” the motto of the ICIDN conference. In particular, it addresses interdisciplinary scientific approaches for systematic understanding of the biology of major human infectious diseases and their treatment regimes by applying the tools and techniques of nanotechnology. It also provides cutting-edge information on infectious diseases and nanomedicine, focusing on various aspects of emerging infectious diseases: cellular and molecular microbiology; epidemiology and infectious disease surveillance; antimicrobials, vaccines and alternatives; drug design, drug delivery and tissue engineering; nanomaterials and biomedical materials.
Infectious Diseases Drug Delivery Systems
by Ranjita Shegokar Yashwant PathakThe disability-adjusted life year (DALY) is a generic measure of health effect that can be used in cost-effectiveness analysis as an alternative to the quality-adjusted life year (QALY). Infectious diseases are one of the major to cause significant losses of DALY and QALY. Human infectious diseases are disorders that are triggered by the micro-organisms such as bacteria, fungi, viruses, or parasites. The majority of such diseases are contagious and create a public health menace. There are several reasons why infectious diseases are deadly diseases, and one of the primary reasons is the drug resistance developed over time. Drug resistance-associated mutations are linked to increasing drug efflux, modifications of the drugs, or their targets. Every year, new drugs are being approved by FDA to treat infectious diseases. Nonetheless, the infectious diseases will undoubtedly persist as permanent and main threats to humanity for now and in the future.A total of four books are covered under the series of Infectious drug diseases.- Malarial drug delivery systems- Tubercular drug delivery systems- Viral drug delivery systems- Infectious disease drug delivery systemsInfectious diseases are the world’s greatest killers that present one of the most significant health and security challenges. Humans have lived with emerging and re-emerging pathogens since before the documented history of civilization. The only determining fact today is - If the situation is “worse” or “better” than in past. The answer is probably “worse”, may be due significant increase in human population, increased cross-continent mobility, imbalanced (stressed) life style, irregular food habits leading to compromised innate immunity and over or under practiced hygiene routine. When the incidence of such a disease in people increases over 20 years or threatens to increase, it is called an “emerging” disease, and a growing number have made watch lists and headlines in nearly every country -like highly pathogenic H5N1 avian influenza, severe acute respiratory syndrome (SARS), Ebola virus, food- and waterborne illnesses, and a range of antimicrobial-resistant bacterial diseases TB. This book addresses current and new therapy developments in treating such infectious diseases, updates on finding new drugs, identification of innovative diagnostic methods, understanding of disease research models and clinical trials performances of new treatment modalities.Audiences from a broad range of groups, from researchers, academicians, and public health bodies to regulatory experts, can benefit from the compiled information to learn more about patient needs and current research advances in the field of infectious diseases and related research.