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Ion Channels and Their Inhibitors
by Satya Prakash GuptaBeing the crucial components of living cells, ion channels are important targets of therapeutic agents. Historically, it has been challenging to develop drugs on this target class. A major issue with target based ion channel drug development is the identification of effective small chemical leads for medicinal chemistry optimization to the clinical candidate status. Thus enough attention has been paid to the study of structure and functions of ion channels and their potential inhibitors. The present book compiles important chapters authored by eminent workers in the field to cover important recent advances in the studies of the structure and functions of ion channels and their inhibitors, such as sodium ion, potassium ion, chloride ion, calcium ion channel inhibitors. The book may be of great use to the students and scientists working in the area of molecular biology, biochemistry, physiology, neurobiology, and medicinal chemistry.
Ion Channels and Transporters of Epithelia in Health and Disease
by Kirk L. Hamilton Daniel C. DevorThis book sheds new light on the physiology, molecular biology and pathophysiology of epithelial ion channels and transporters. It combines the basic cellular models and functions by means of a compelling clinical perspective, addressing aspects from the laboratory bench to the bedside. The individual chapters, written by leading scientists and clinicians, explore specific ion channels and transporters located in the epithelial tissues of the kidney, intestine, pancreas and respiratory tract, all of which play a crucial part in maintaining homeostasis. Further topics include the fundamentals of epithelial transport; mathematical modeling of ion transport; cell volume regulation; membrane protein folding and trafficking; transepithelial transport functions; and lastly, a discussion of transport proteins as potential pharmacological targets with a focus on the pharmacology of potassium channels.
Ion Channels as Targets in Drug Discovery
by Gary Stephens Edward StevensThis book is built around ion channel research and, more specifically, ion channels as important therapeutic drug targets. Under the editorial leadership of Gary Stephens in academic research and Edward Stevens from industry, the aim is to bring these strands together to provide a cutting-edge translational reference on ion channel drug discovery. Exploiting our knowledge of ion channel structure and function has clear current and future potential to intervene and correct the pathophysiology associated with debilitating conditions, including cardiovascular disease, diabetes, cystic fibrosis, pain, epilepsy, and neurodegenerative disorders. Individual chapters have a disease focus, also providing a “case study story” that will also appeal to a clinical audience, while background information on a given ion channel is presented to provide a solid reference for undergraduate and postgraduate teaching.
Ion Channels in Biophysics and Physiology (Advances in Experimental Medicine and Biology #1349)
by Lei ZhouThis book gathers relatively recent and significant topics in the field of ion channel research. Ion channels form the molecular basis for membrane excitability in cells from the cardiovascular and nervous systems. In many non-excitable cells, ion channels contribute to diverse function including secretion of signaling compounds like hormones and insulin, cell volume regulation, intracellular signaling especially Ca2+ signaling, etc. Many human diseases have been attributed to abnormal channel functions and defective membrane expression of channel proteins. On the other hand, ion channels are excellent models for studying protein biophysics, especially the allosteric regulation of protein function by miscellaneous stimuli. Therefore, researches on ion channels carry significant meaning for the understanding of basic protein biophysics and diverse physiological functions and for developing novel and effective treatment for related human diseases. This book could provide graduates and scientists in both basic and clinical levels, a comprehensive understanding of cutting-edge advances and a useful and stimulating platform for tackling their own questions about ion channels.
Ion Correlations at Electrified Soft Matter Interfaces
by Nouamane LaanaitIon Correlations at Electrified Soft Matter Interfaces presents an investigation that combines experiments, theory, and computer simulations to demonstrate that the interdependency between ion correlations and other ion interactions in solution can explain the distribution of ions near an electrified liquid/liquid interface. The properties of this interface are exploited to vary the coupling strength of ion-ion correlations from weak to strong while monitoring their influence on ion distributions at the nanometer scale with X-ray reflectivity and on the macroscopic scale with interfacial tension measurements. This thesis demonstrates that a parameter-free density functional theory that includes ion-ion correlations and ion-solvent interactions is in agreement with the data over the entire range of experimentally tunable correlation coupling strengths. The reported findings represent a significant advance towards understanding the nature and role of ion correlations in charged soft-matter. Ion distributions underlie many scientific phenomena and technological applications, including electrostatic interactions between charged biomolecules and the efficiency of energy storage devices. These distributions are determined by interactions dictated by the chemical properties of the ions and their environment, as well as the long-range nature of the electrostatic force. The presence of strong correlations between ions is responsible for counterintuitive effects such as like-charge attraction.
Ion Exchange Membranes: Design, Preparation, and Applications
by Tongwen Xu Yaoming WangIon Exchange Membranes A comprehensive introduction to the electro-membrane technologies of the future An ion exchange membrane is a polymer-based membrane which can be permeable by some ions in a solution while blocking others, making them ideal for processes such as water desalination, salt concentration control, clean production and—given their electrical conductivity—power generation and energy storage etc. Recent advances have given rise to new electro-membrane processes that promise drastically to expand the applications of this technology. Scientists in both research and industry will increasingly need to draw on these membranes in vital ways with strongly positive potential environmental impact. Ion Exchange Membranes summarizes recent research into these membranes and electro-membrane processes before moving to an overview of the historical background. It then attends in detail to cutting-edge fabrication technologies and the most recent areas of use. The result is a comprehensive introduction to the design, fabrication, and applications of these increasingly essential membranes. Ion Exchange Membranes readers will also find: In-depth treatment of industrial-scale applications Detailed discussion of topics including side-chain engineering, polyacylation, superacid-catalyst polymerization, and more Analysis of electro-membrane processes such as alkaline membrane water electrolysis, solar-driven water splitting, and many more Ion Exchange Membranes is ideal for membrane scientists, materials scientists, inorganic chemists, polymer chemists, and researchers and engineers in a variety of fields working with ion exchange membranes and electro-membrane processes.
Ion Exchange Technology I
by Mohammad Luqman Inamuddin Dr.Ion-exchange Technology I: Theory and Materials describes the theoretical principles of ion-exchange processes. More specifically, this volume focuses on the synthesis, characterization, and modelling of ion-exchange materials and their associated kinetics and equilibria. This title is a highly valuable source not only to postgraduate students and researchers but also to industrial R&D specialists in chemistry, chemical, and biochemical technology as well as to engineers and industrialists.
Ion Exchange Technology II
by Dr Inamuddin Mohammad LuqmanIon-exchange Technology II: Applications presents an overview of the numerous industrial applications of ion-exchange materials. In particular, this volume focuses on the use of ion-exchange materials in various fields including chemical and biochemical separations, water purification, biomedical science, toxic metal recovery and concentration, waste water treatment, catalysis, alcohol beverage, sugar and milk technologies, pharmaceuticals industry and metallurgical industries. This title is a highly valuable source not only to postgraduate students and researchers but also to industrial R&D specialists in chemistry, chemical, and biochemical technology as well as to engineers and industrialists.
Ion Exchange Technology: Advances in Pollution Control
by Arup K. SenGuptaThis book provides comprehensive coverage of developments in ion exchange areas which would continue to have major impacts in the general pursuit of pollution control and pollution prevention. Its nine chapters can be split into four different theme areas: trace contaminants removals; new materials; desalination and finally controlling gaseous pollutants. This would have value for practicing engineers, scientists and researchers who are pertaining to ion exchange technology. It would also server the needs of those trying to explore and identify new technologies in the areas of pollution control and pollution prevention.
Ion Exchange and Solvent Extraction: A Series of Advances, Volume 11 (Ion Exchange And Solvent Extraction Ser. #11)
by Yizhak Marcus Jacob A. MarinskyThe Ion Exchange and Solvent Extraction series treats ion exchange and solvent extraction both as discrete topics and as a unified, multidisciplinary study - presenting new insights for researchers in many chemical and related field. Containing current knowledge and results in ion exchange, this text: presents an overview of the chemical thermodynamics of cation-exchange reactions, with particular emphasis placed on liquid-phase- and solid-phase-activity coefficient models; describes the development of surface complexation theory and its application to the ion exchange phenomenon; discusses metal-natural colloid surface reactions and their consideration by surface complexation modelling complements; and covers the influence of humic substances on the uptake of metal ions by naturally occurring materials.
Ion Exchange and Solvent Extraction: A Series of Advances, Volume 12 (Ion Exchange And Solvent Extraction Ser. #13)
by Jacob A. MarinskyThe Ion Exchange and Solvent Extraction series treats ion exchange and solvent extraction both as discrete topics and as a unified, multidisciplinary study - presenting new insights for researchers in many chemical and related fields.;Volume 12 contains coverage of: the nature of metal-ion interaction with oppositely charged sites of ion exchangers; high-pressure ion exchange separation of rare earth elements; the commercial recovery of valuable minerals from seawater and brines by ion exchange and sorption; the kinetics of ion exchange in heterogenous systems; the ion-exchange equilibria of amino acids; and more.;The work is intended for analytical, co-ordination, process, separation, surface, organic, inorganic, physical and environmental chemists, geochemists, electrochemists, radiochemists, biochemists, biophysicists, hydrometallurgists, membrane researchers and chemical engineers.
Ion Exchange and Solvent Extraction: A Series of Advances, Volume 13 (Ion Exchange And Solvent Extraction Ser.)
by Jacob A. Marinsky; Yizhak Marcus"Volume 13 of this important series continues in the tradition of its widely received predecessors, presenting current advances and results in solvent extraction. Contains nearly 800 helpful drawings, tables, equations and bibliographic citations."
Ion Exchange and Solvent Extraction: A Series of Advances, Volume 14
by Yizhak Marcus Arup K. SenGupta Jacob A. MarinskyThis text introduces a special class of polymeric ligand exchanger (PLE) with high affinities for anionic ligands. Volume 14 discusses the potential and advantages of micro- and nanofiltration membrane processes for removal of metals; details prevailing equilibrium relationships and supporting experimental data for systems where leaching and ion ex
Ion Exchange and Solvent Extraction: A Series of Advances, Volume 15 (Ion Exchange and Solvent Extraction Series)
by Yizhak Marcus Arup K. SenGupta Jacob A. Marinsky"Contains a complete manual with procedures for the implementation and scaling-up of industrial extraction processes. Discusses computer-aided molecular design. Includes examples of interactive, combinatorial, construct-and-test, and mathematical programming."
Ion Exchange and Solvent Extraction: A Series of Advances, Volume 16 (Ion Exchange and Solvent Extraction Series #Vol. 16)
by Yizhak Marcus Arup K. SenGupta Jacob A. MarinskyReflecting the sustained and diverse experimental momentum in the field of ion exchange, Volume 16 summarizes revolutionary advances on par with the consistently high-level research related by this series. This text discusses the kinetics, theoretical models, experimental results/supporting data, and applications for isothermal supersaturation, met
Ion Exchange and Solvent Extraction: A Series of Advances, Volume 17 (Ion Exchange and Solvent Extraction Series)
by Yizhak Marcus Arup K. SenGupta Jacob A. MarinskyVolume 17 in the Ion Exchange and Solvent Extraction series represents the vanguard of research on solvent extraction. It covers the principles of electrolyte extraction and other subjects of increasing interest to the field. This volume begins with pharmaceutical applications of supercritical fluid solvents, particularly supercritical carbon dioxi
Ion Exchange and Solvent Extraction: A Series of Advances, Volume 18 (Ion Exchange And Solvent Extraction Ser.)
by Arup K. SenGuptaAlternating the focus of the series each year, the new volume in the Ion Exchange and Solvent Extraction series represents the vanguard of research in ion exchange. Ion Exchange and Solvent Extraction: A Series of Advances, Volume 18 reflects the remarkable breadth of applications inspiring the latest advances, featuring carefully selected contribu
Ion Exchange and Solvent Extraction: A Series of Advances, Volume 19 (Ion Exchange and Solvent Extraction Series)
by Bruíea. MoyerThe growth in the world's nuclear industry, motivated by peaking world oil supplies, concerns about the greenhouse effect, and domestic needs for energy independence, has resulted in a heightened focus on the need for next-generation nuclear fuel-cycle technologies. Ion Exchange and Solvent Extraction: A Series of Advances, Volume 19 provides a com
Ion Exchange and Solvent Extraction: A Series of Advances, Volume 20 (Ion Exchange and Solvent Extraction Series)
by Arup K. SenguptaOver the past four decades, notable advancements in the theory and application of ion exchange science uncovered a wealth of knowledge that fueled new scientific pursuits and created synergies with myriad scientific endeavors. Today, pioneers continue to break new ground by synthesizing novel materials and merging the interdisciplinary fields of sc
Ion Exchange and Solvent Extraction: A Series of Advances, Volume 22 (Ion Exchange and Solvent Extraction Series #Vol. 16)
by Arup K. SenguptaSince the Second World War, the field of ion exchange has taken a dominant role in offering solutions to many problems in the developed and developing world. It has evolved to a wide array of applications, including mining, microelectronics, drug delivery and detection, food, fertilizers, chemical cleaning, catalysis, bioseparation, water management, environmental research and practices, and energy. The six chapters in this book represent diverse contributions from researchers around the globe who are making noticeable strides in the field in currently important areas: Brackish water desalination Removing boron from water Sustainable approaches for synthesizing commercially important epoxide building blocks Solid-phase heavy-metal separation Separating concentrated ion mixtures in sorption columns Sensing toxic metals Ion Exchange and Solvent Extraction: A Series of Advances, Volume 22 provides a focused review of new materials and new processes that have developed and are rapidly growing. It describes cutting-edge research and practices in the use of ion exchange for building a cleaner, sustainable world and provides thoughtful insights on what ion exchange may do for us in the future.
Ion Exchange and Solvent Extraction: Volume 21, Supramolecular Aspects of Solvent Extraction
by Bruce A. MoyerOver the past several decades, the theme of supramolecular chemistry (SC) has permeated nearly all aspects of chemical endeavor. Not surprisingly, it has also pervaded the field of solvent extraction (SX), inspiring the framework for this volume of Ion Exchange and Solvent Extraction. In addition, tools for studying aggregation have grown increasin
Ion Exchange and Solvent Extraction: Volume 23, Changing the Landscape in Solvent Extraction (Ion Exchange and Solvent Extraction Series #23)
by Bruce A MoyerThis volume will capture transformational changes in both the chemistry and engineering side of solvent extraction, creating new directions and deepening our understanding of the structure and dynamics of liquid-liquid systems from the molecular- to nano- to meso- to bulk-scale. Reviews will cover advances in microfluidics, new tools for understanding the structure and dynamics of the liquid-liquid interface, ionic liquids in liquid-liquid extraction, molecular dynamics to visualize interactions in the solvent phase, liquid-liquid electrochemistry to interrogate the energetics of interfacial transport and complexation, design of new extractants, and the streamlining of process applications.
Ion Exchange in Environmental Processes: Fundamentals, Applications and Sustainable Technology
by Arup K. SenguptaProvides a comprehensive introduction to ion exchange for beginners and in-depth coverage of the latest advances for those already in the field As environmental and energy related regulations have grown, ion exchange has assumed a dominant role in offering solutions to many concurrent problems both in the developed and the developing world. Written by an internationally acknowledged leader in ion exchange research and innovation, Ion Exchange: in Environmental Processes is both a comprehensive introduction to the science behind ion exchange and an expert assessment of the latest ion exchange technologies. Its purpose is to provide a valuable reference and learning tool for virtually anyone working in ion exchange or interested in becoming involved in that incredibly fertile field. Written for beginners as well as those already working the in the field, Dr. SenGupta provides stepwise coverage, advancing from ion exchange fundamentals to trace ion exchange through the emerging area of hybrid ion exchange nanotechnology (or polymeric/inorganic ion exchangers). Other topics covered include ion exchange kinetics, sorption and desorption of metals and ligands, solid-phase and gas-phase ion exchange, and more. Connects state-of-the-art innovations in such a way as to help researchers and process scientists get a clear picture of how ion exchange fundamentals can lead to new applications Covers the design of selective or smart ion exchangers for targeted applications—an area of increasing importance—including solid and gas phase ion exchange processes Provides in-depth discussion on intraparticle diffusion controlled kinetics for selective ion exchange Features a chapter devoted to exciting developments in the areas of hybrid ion exchange nanotechnology or polymeric/inorganic ion exchangers Written for those just entering the field of ion exchange as well as those involved in developing the “next big thing” in ion exchange systems, Ion Exchange in Environmental Processes is a valuable resource for students, process engineers, and chemists working in an array of industries, including mining, microelectronics, pharmaceuticals, energy, and wastewater treatment, to name just a few.
Ion Exchange: Highlights Of Russian Science
by Dmitri Muraviev Vladimir Gorshkov Abraham WarshawskyThis text offers the best of ion exchange science conducted in the countries of the former Soviet Union. It reviews the multidisciplinary study at the nexus of physical, organic, inorganic and biological chemistries, and progresses from theoretical fundamentals to practical applications in manufacturing, mineral refining and environmental clean-up. The text examines advances and phenomena observed in ion-exchange systems.
Ion Irradiation of Dielectrics for Photonic Applications (Springer Series in Optical Sciences #231)
by Feng Chen Hiroshi Amekura Yuechen JiaThis book focuses on the fundamentals, technologies and properties of ion irradiation of dielectric materials (e.g. glasses, crystals) with regard to various photonic applications. It introduces readers to diverse ion-beam techniques for the fabrication and modification of micron- or nanoscale photonic structures, including optical waveguides, photonic crystals, and nanoparticle (nano-spheres and nano-rods) systems, and presents state-of-the-art advances in this multi-disciplinary research field, demonstrating the unique capabilities of ion-beam technologies in optical dielectric materials processing. The book discusses in detail the properties of ion-beam processed waveguides, as well as the modification of dielectrics for photonic applications, such as electro-optic modulation, nonlinear frequency conversion, waveguide amplification and lasing. It also explores synthesis and the correlated optical effects of nanoparticles by ion beams, and features examples of successful micro- and nano-photonic devices. Given its breadth of coverage, the book will particularly appeal to readers interested in ion-beam technology, materials science, and integrated optics.