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Ion Mobility Spectrometry
by G.A. Eiceman Z. Karpas Herbert H. Hill Jr.Since the turn of the twenty-first century, applications of ion mobility spectrometry (IMS) have diversified, expanding their utility in the military and security spheres and entering the realms of clinical practice and pharmaceutical exploration. Updated and expanded, the third edition of Ion Mobility Spectrometry begins with a comprehensive discu
Ion Mobility Spectrometry - Mass Spectrometry: Theory and Applications
by Charles L. Wilkins Sarah TrimpinThe analytical power of ion mobility spectrometry-mass spectrometry (IMS-MS) instruments is poised to advance this technology from research to analytical laboratories. Exploring these developments at this critical juncture, Ion Mobility Spectrometry-Mass Spectrometry: Theory and Applications covers the tools, techniques, and applications involved when molecular size and shape information is combined with the well-known analytical advantages of high-performance mass spectrometry.One of the Most Exciting Developments in Contemporary Mass SpectrometryAfter presenting an overview chapter and the fundamentals, the book focuses on instrumentation and ionization sources. It describes an ion-mobility-capable quadrupole time-of-flight mass spectrometer, the differential mobility analyzer, a cryogenic-temperature ion mobility mass spectrometer, the atmospheric solids analysis probe method, and laserspray ionization. In the final applications-oriented chapters, the contributors explore how homebuilt and commercial instruments using electrospray ionization and matrix-assisted laser desorption/ionization (MALDI) methods are employed to solve biological and synthetic issues.Harness the Power of IMS-MS for Analyzing Complex SubstancesThis work helps readers unfamiliar with IMS-MS to understand its fundamental theory and practical applications. It also encourages them to investigate the potential analytical uses of IMS-MS and further explore the power of this method. Numerous color figures are included on downloadable resources.
Ion Mobility-Mass Spectrometry: Methods and Protocols (Methods in Molecular Biology #2084)
by Giuseppe Paglia Giuseppe AstaritaThis book focuses on ion mobility-mass spectrometry (IM-MS) and informatics approaches to improve traditional analysis of molecules by providing fundamentals and protocols for exploiting the potential of state-of-the-art IM-MS technology for the most common analytical applications. The chapters have been organized into four parts, each dealing with a particular set of IM-MS applications: 1) metabolomics and lipidomics; 2) proteomics and glycomics; 3) imaging and ambient ionization IM-MS; and 4) bioinformatic solutions for analyzing IM-MS data and deriving CCS values. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Ion Mobility-Mass Spectrometry: Methods and Protocols serves as an ideal resource for scientists delving into the technique's unprecedented analytical advantages, enabling novel qualitative and quantitative applications for the analysis of complex biological samples.
Ion Selective Electrode Method: Volume 1
by A.K. CovingtonThe intention was to produce a book which perforce would never be far from the laboratory, although CRC‘s use of Handbook in another connection precludes our use of that word in the title.
Ion Selective Electrode Method: Volume 2
by A.K. CovingtonThe intention was to produce a book which perforce would never be far from the laboratory, although CRC‘s use of Handbook in another connection precludes our use of that word in the title.
Ion Tracks in Apatite and Quartz: And Their Behaviour With Temperature And Pressure (Springer Theses)
by Daniel SchauriesThis book pioneers a novel approach to investigate the effects of pressure on fission tracks, a geological problem that has remained unsolved for 60 years. While conventional techniques to study fission tracks were limited in precision, this book overcomes such issues by using state-of-the-art synchrotron-based x-ray scattering; a technique initially developed for applications in material science and biomedical research. The book provides an overview of the theory and application of small angle x-ray scattering (SAXS) on cylindrical ion tracks, including in-situ SAXS on ion tracks with simultaneous increases in temperature and pressure. As such it demonstrates a degree of characterisation normally not achievable with in-situ techniques. Further, it compares SAXS with small angle neutron scattering (SANS). This book has led to a range of publications and attracted the interest of the geological and material science communities. Daniel Schauries has been awarded several prizes for this research, including the Graduate Student Award of the Materials Research Society.
Ion Transport Across Epithelial Tissues and Disease: Ion Channels and Transporters of Epithelia in Health and Disease - Vol. 2 (Physiology in Health and Disease)
by Kirk L. Hamilton Daniel C. DevorThis book discusses the unique ion channels and transporters found within the epithelial tissues of various organs, including the kidney, intestine, pancreas and respiratory tract. Authors focus on demonstrating the crucial roles that each of these channels and transporters play in transepithelial ion and fluid transport across epithelia, as well as in maintaining homeostasis. It allows readers to gain an understanding of the fundamentals of ion transport, in terms of function, modelling, regulation, trafficking, structure and pharmacology. This is the second of three volumes highlighting the importance of epithelial ion channels and transporters in basic physiology and pathophysiology of human diseases. This volume focuses on a wide array of epithelial tissues and the use of organoids to study epithelial function. Furthermore, clinical researchers and basic scientists from various fields provide a medical perspective on the physiology of a number of tissues and organs of the body including the pancreas, intestine, sweat glands, mammary gland, inner ear epithelia, retinal pigment epithelia of the eye, choroid plexus, and the ectodermal epithelia in dental enamel formation. This volume aims to ‘round out’ the reader’s journey from basic science to the laboratory bench and clinical management of molecular diseases, making Volume 2 a must-read for students and scientists in the field of physiology, as well as for clinicians.
Ion and Molecule Transport in Lysosomes (Methods in Signal Transduction Series)
by Bruno Gasnier Michael X. ZhuLysosomes are key subcellular organelles that regulate the cell function. Many of the essential activities of the cell are dependent on lysosomes. Dysfunction is linked to multiple diseases - storage disorders, neurodegeneration, immunological diseases and cancer. This book discusses concepts and methods used to study lysosome ion and small molecule transport. The contents will not only attract accomplished investigators in need of a broad review and synthesis of this important subject but will also appeal to young investigators and trainees needing to acquire comprehensive knowledge and technical skills working with lysosomal ion channels and small molecule transporters. Key selling features: Summarizes the endocellular role that lysosomes play with respect to cellular waste disposal Reviews essential cellular functions of lysosomes Explores how lysosome dysfunction is the cause of many metabolic disorders Examines how lysomes are involved in storage diseases Describes various technologies and methods used in lysosome research
Ion-Exchange Chromatography of Proteins
by Shuichi Yamamoto Kazahiro Nakanishi Ryuichi MatsunoShowing chemists how to predict ion-exchange chromatography (IEC) separation behaviour and how to determime appropriate operating conditions, this reference illustrates procedures, apparatus and types of ion exchanges, emphasizing the design and application of large-scale IEC. Complete with more than 100 useful tables and diagrams, this text explains the effects of each variable on separation behaviour; compares models and equations describing behaviour of proteins in IEC with experimental results; introduces design calculation procedures for scale up, adapting IEC for individual requirements; discusses parameters affecting separation behaviour, including adsorption equilibria, stationary phase diffusion and axial dispersion; provides examples of applications, such as high or medium performance IEC and large scale operations and reviews both theorectical and experimental literature. This text serves as an reference for analytical, agricultural, food, and pharmaceutical chemists, chromatographers, food scientists and technologists, biochemists and biotechnologists.
Ion-Pair Chromatography and Related Techniques (Analytical Chemistry)
by Teresa CecchiIon-Pair Chromatography (IPC) is a rapidly evolving method for difficult analyses of organic and inorganic ions and ionogenic, neutral, and zwitterionic compounds. The possibilities for this technology continue to grow as novel ion-pair reagents and strategies are introduced at an accelerated level. Compensating for a dearth in the literature, Ion-
Ion-Radical Organic Chemistry: Principles and Applications, Second Edition
by Zory Vlad TodresConsolidating knowledge from a number of disciplines, Ion-Radical Organic Chemistry: Principles and Applications, Second Edition presents the recent changes that have occurred in the field since the publication of the first edition in 2003. This volume examines the formation, transformation, and application of ion-radicals in typical conditions of
Ion-Selective Electrodes
by Konstantin N. MikhelsonIon-selective electrodes (ISEs) have a wide range of applications in clinical, environmental, food and pharmaceutical analysis as well as further uses in chemistry and life sciences. Based on his profound experience as a researcher in ISEs and a course instructor, the author summarizes current knowledge for advanced teaching and training purposes with a particular focus on ionophore-based ISEs. Coverage includes the basics of measuring with ISEs, essential membrane potential theory and a comprehensive overview of the various classes of ion-selective electrodes. The principles of constructing ISEs are outlined, and the transfer of methods into routine analysis is considered. Advanced students, researchers, and practitioners will benefit from this expedient introduction.
Ion-Selective Electrodes for Biological Systems
by Christopher Fry Stephen Langley E. N. Stephen LangleyIon -Selective Electrodes for Biological Systems provides a user-friendly and practical guide to the manufacture and use of ion-selective electrodes for a wide variety of experimental systems used in biology. The book is aimed at researchers with little practical experience in the field and will direct them through the steps involved in making elec
Ion/Molecule Attachment Reactions: Mass Spectrometry
by Toshihiro FujiiThis book explores the mechanism of alkali-metal ion/molecule association reaction, surveys the instrumental basis to study its kinetic, and describes the instrumentation to the measurement of alkali-metal ion affinities. The applications of the ion complexation mechanism in the condensed phase in reaction to direct analysis MS are also covered. Other topics include mechanism and reaction rate, experimental and theoretical ion affinities, applications of ion attachment reactions (IAR) to mass spectrometry such as alkali ion CIMS, ion attachment MS and cationization mass spectrometry of ESI, FAB, FD, LD, MALDI and SIMS and topics of IAR-based direct analysis mass spectrometry.
Ionenchromatographie
by Joachim WeissDas Standardwerk zur Ionenchromatographie jetzt in einer erweiterten und gründlich überarbeiteten dritten Auflage! Seit vielen Jahren hat sich der "Weiß" als umfassendes Handbuch der Ionenchromatographie bewährt. Der Anwender findet darin alle wesentlichen Informationen zu den Grundlagen, den Geräten, den stationären und mobilen Phasen sowie zu den vielfältigen Anwendungsmöglichkeiten. Neu in der dritten Auflage sind: - ein eigenes Kapitel zur Ionenaustausch-Chromatographie - Informationen zur Validierung ionenchromatographischer Methoden - Kopplungstechniken zur Massenspektrometrie, einschließlich ICP/MS - Anwendungen zur Analyse von Kohlenhydraten, Proteinen und Nukleinsäuren - Viele neue Abbildungen und Chromatogramme Joachim Weiß arbeitet für den führenden Gerätehersteller auf dem Gebiet der Ionenchromatographie und ist Gastprofessor an der Universität Innsbruck.
Ionic Equilibria in Analytical Chemistry
by Jean-Louis BurgotThis book of general analytical chemistry - as opposed to instrumental analysis or separation methods - in aqueous solutions is focuses on fundamentals, which is an area too often overlooked in the literature. Explanations abound of the chemical and physical principles of different operations of chemical analysis in aqueous solutions. Once these principle are firmly established, numerous examples of applications are also given.
Ionic Interactions in Natural and Synthetic Macromolecules
by Alberto Ciferri Angelo PericoThis book is a comprehensive study of the subject of ionic interactions in macromolecules. The first parts of the book review and analyze the conventional treatments of fixed charges (e. g. in polyelectrolytes and polyampholytes), including screening and condensation by mobile ions. The interaction of ions with less polar sites on the macromolecule (e. g. amide bonds), and the origin of the lyotropic effects (focusing on binding versus condensation) will also be extensively addressed. The book also explores complex micellar organizations involving charged macromolecules (e. g. DNA) and low-molecular-weight ampholytes and strong protein associations. The resulting structures are relevant to a variety of functional biological systems and synthetic analogs. The contribution of electrostatic and hydrophobic interaction to the stability of proteins and other supramolecular structures will also be analyzed. There are chapters on applications such as deionization and cosmetic formulation. This 21-chapter book is divided into three sections: Fundamentals Mixed Interactions Functions and Applications
Ionic Liquid Bulk and Interface Properties
by Till CremerIn this thesis, Till Cremer investigates the bulk properties of ionic liquids (IL), the IL/vacuum interface and the IL/solid interface. For these studies the author primarily uses angle-resolved X-ray photoelectron spectroscopy under ultrahigh vacuum conditions. ILs represent a class of materials with unique physico-chemical properties. Many applications take advantage of the extremely low vapor pressure of aprotic ILs to fabricate permanent, non-volatile liquid coatings on solid materials. The author focuses on issues related to thin IL coatings, in particular concerning new catalytic concepts such as the supported ionic liquid phase (SILP) and solid catalyst with ionic liquid layer (SCILL) systems. Till Cremer presents a number of fundamental contributions to the new field of "Ionic Liquid Surface and Interface Science". Highlights are his results concerning anion/cation-interactions and the growth of ultrathin layers of ionic liquids on various substrates in the context of supported ionic liquid catalysis. His results have significantly contributed to the present level of understanding in the field and accordingly he is author and coauthor of ten publications on the topic in high-ranked journals.
Ionic Liquid Catalyzed Reactions: Green Concepts and Sustainable Applications
by Zhimin Liu Yanfei ZhaoUnderstand the applications of ionic liquid catalysis with this cutting-edge overview Ionic liquids have distinctive properties that have made them the subject of vigorous research in recent decades. They have primarily been seen as potential green alternatives to volatile organic solvents, and therefore as a vital tool in the development of sustainable industry. In fact, however, ionic liquids can also serve as catalysts, catalyst immobilizers, and initiators, with the result that they have been applied in over 100 known types of chemical reactions. Ionic Liquid Catalyzed Reactions: Green Concepts and Sustainable Applications offers a detailed overview of these reactions and the catalytic mechanism of ionic liquids. It surveys cutting-edge research into ionic liquid catalysis and the concepts, perspectives, and skills needed for scientists to incorporate it into a range of experimental fields. It is a must-own for anyone looking to understand the range and variety of uses for ionic liquid catalysis. Ionic Liquid Catalyzed Reactions readers will also find: Case studies throughout showing ionic liquid catalysis applications Information for scientists working in organic chemistry, electrochemistry, biotechnology, and many more Detailed coverage of reactions including CO2 conversion, biomass transformation, organic synthesis, and many others Ionic Liquid Catalyzed Reactions is ideal for catalytic chemists, organic chemists, environmental chemists, electrochemists, and anyone else working with chemical catalysis in need of new experimental methods.
Ionic Liquid Properties
by Yizhak MarcusThis volume deals with substances in the liquid state that range from high melting salts, such as calcium fluoride, through slags, such as silicates, down to lower melting salts, such as lithium nitrate, molten hydrated salts, such as magnesium chloride hexahydrate, to room temperature ionic liquids, such as 1,3-dimethylimmidazolium tetraphenylborate. It provides the reader with annotated, critically examined, and compiled data for such materials. The data includes a variety of thermochemical, structural, and transport properties. The book includes correlations of measured properties; these correlations should enable the reader to estimate, on a sound basis, properties for ionic liquids that have not yet been measured.
Ionic Liquid-Based Surfactant Self-Assemblies
by Werner Kunz Satya P. Moulik Bidyut K. PaulThis volume will be summarized on the basis of the topics of Ionic Liquids in the form of chapters and sections. It would be emphasized on the synthesis of ILs of different types, and stabilization of amphiphilic self-assemblies in conventional and newly developed ILs to reveal formulation, physicochemical properties, microstructures, internal dynamics, thermodynamics as well as new possible applications. It covers: Topics of ionic liquid assisted micelles and microemulsions in relation to their fundamental characteristics and theories Development bio-ionic liquids or greener, environment-friendly solvents, and manifold interesting and promising applications of ionic liquid based micelles and micremulsions
Ionic Liquids (ILs) in Organometallic Catalysis
by Jairton Dupont László KollárThe series Topics in Organometallic Chemistry presents critical overviews of research results in organometallic chemistry. As our understanding of organometallic structure, properties and mechanisms increases, new ways are opened for the design of organometallic compounds and reactions tailored to the needs of such diverse areas as organic synthesis, medical research, biology and materials science. Thus the scope of coverage includes a broad range of topics of pure and applied organometallic chemistry, where new breakthroughs are being achieved that are of significance to a larger scientific audience. The individual volumes of Topics in Organometallic Chemistry are thematic. Review articles are generally invited by the volume editors. All chapters from Topics in Organometallic Chemistry are published OnlineFirst with an individual DOI. In references, Topics in Organometallic Chemistry is abbreviated as Top Organomet Chem and cited as a journal
Ionic Liquids Completely UnCOILed: Critical Expert Overviews
by Kenneth R. Seddon Natalia V. PlechkovaCritical overviews from the front line of ionic liquids research Ionic Liquids Completely UnCOILed: Critical Expert Overviews concludes the discussion of new processes and developments in ionic liquid technology introduced in the previously published volumes, Ionic Liquids UnCOILed and Ionic Liquids Further UnCOILed. The goal of this volume is to provide expert overviews that range from applied to theoretical, synthetic to structural, and analytical to toxicological. The value of book lies in the authors’ expertise, and their willingness to share it with the reader. Written by an international group of chemists, the book presents eleven overviews of specific areas of ionic liquid chemistry including: What is an Ionic Liquid? Molecular modelling Crystallography Chemical engineering of ionic liquid processes Toxicology and Biodegradation Organic reaction mechanisms Edited by Professor Ken Seddon and Dr Natalia Plechkova, world leaders in the field of ionic liquids, this book is a must read for R&D chemists, educators, and students, and for commercial developers of environmentally sustainable processes. It offers insight and appreciation for the direction in which the field is going, while also highlighting the best published works available, making it equally valuable to new and experienced chemists alike.
Ionic Liquids UnCOILed: Critical Expert Overviews
by Kenneth R. Seddon Natalia V. PlechkovaIonic Liquids UnCOILed presents decisively important reviews on new processes and recent developments in ionic liquid technology with an emphasis on commercial applications in which ionic liquids are replacing, or may replace, processes currently using conventional solvents. Ranging from applied to theoretical, synthetic to analytical, and biotechnological to electrochemical, the book features eleven chapters written by an international group of key academic and industrial chemists, exercising the judicious evaluation which they are uniquely qualified to do. This book is a must for R&D chemists in industrial, governmental and academic laboratories, and for commercial developers of environmentally-friendly, sustainable processes.