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Metalloenzymes as Inspirational Electrocatalysts for Artificial Photosynthesis
by Andreas S. J. L. BachmeierThis thesis describes a series of investigations designed to assess the value of metalloenzymes in systems for artificial and adapted photosynthesis. The research presented explores the interplay between inherent enzyme properties such as structure, rates and thermodynamics, and the properties of the semiconducting materials to which the enzyme is attached. Author, Andreas Bachmeier provides a comprehensive introduction to the interdisciplinary field of artificial photosynthesis, allowing the reader to grasp the latest approaches being investigated, from molecular systems to heterogeneous surface catalysis. Bachmeier's work also uses metalloenzymes to highlight the importance of reversible catalysts in removing the burden of poor electrocatalytic rates and efficiencies which are common characteristics for most artificial photosynthesis systems. Overall, this thesis provides newcomers and students in the field with evidence that metalloenzymes can be used to establish new directions in artificial photosynthesis research.
Metallofoldamers
by Galia Maayan Markus AlbrechtMetallofoldamers are oligomers that fold into three-dimensional structures in a controlled manner upon coordination with metal ions. Molecules in this class have shown an impressive ability to form single-handed helical structures and other three-dimensional architectures. Several metallofoldamers have been applied as sensors due to their selective folding when binding to a specific metal ion, while others show promise for applications as responsive materials on the basis of their ability to fold and unfold upon changes in the oxidation state of the coordinated metal ion, and as novel catalysts.Metallofoldamers: From Helicates to Biomimetic Architectures describes the variety of interactions between oligomers and metal species, with a focus on non-natural synthetic molecules.Topics covered include:the major classes of foldamers and their folding driving forcemetalloproteins and metalloenzymeshelicates: self-assembly, structure and applicationsabiotic metallo-DNAmetallo-PNA and iDNAmetallopeptidesinteractions of biomimetic oligomers with metal ionsapplications of metallofoldamers
Metallography in Archaeology and Art (Cultural Heritage Science)
by David A. Scott Roland SchwabThis book provides a comprehensive introduction to the metallographic study of ancient metals. Metallography is important both conceptually as a microstructural science and in terms of its application to the study of ancient and historic metals. Metallography is a well-established methodology for the characterization of the microstructure of metals, which continues to be significant today in quality control and characterization of metallic properties. Not only does the metallographic examination of ancient metals present its own challenges in terms of sample size and interpretation of evidence, but it must be integrated with archaeological data and cultural research in order to obtain the most meaningful results. Issues of authentication and the establishment of fakes and forgeries of metallic artefacts often involve metallographic evidence of both metal and patina or corrosion interface, as an essential component of such a study. The present volume sets out the basic features of relevant metallic systems, enhanced with a series of examples of typical microstructural types, with illustrative case studies and examples throughout the text derived from studies undertaken by the two authors. This book provides a comprehensive presentation of metallography for archaeologists, archaeometallurgists, conservators, conservation scientists and metallurgists of modern materials.
Metalloids in Biology: From Function to Toxicity
by Renu Bhardwaj Geetika Sirhindi Nitika Kapoor Chandra Shekhar SethMetalloids belong to class of elements that exhibit physiochemical characteristics intermediating between those of metals and non-metals. Some are quasi-essential for the overall growth and development of plants. Silicon, for instance, enhances plant structural integrity, while boron is crucial for cell wall formation, and selenium acts as an antioxidant but some are toxic, like germanium (Ge) and arsenic (As), as they threaten the soil ecosystem and human health. Metalloid toxicity hinges on their cellular concentrations ,where low levels aid plant development ,whereas high levels cause harmful effects. Thus, it is crucial to encompass the underlying detoxification mechanisms behind metalloid uptake by root system, their transport to other tissues, and their redistribution within and between cells. This book provides a comprehensive elucidation of the valuable insights of metalloids in green agriculture emphasizing management strategies to mitigate their adverse effects through various detoxification pathways, including cell complexation, cell wall binding, efflux, vacuolar sequestration and ultimately redistribution. Key features:1.Explores databases of metalloid distribution in plants and other habitats. 2.Deliberates about metalloid transporters and detoxification strategies in plants. 3. Describes interaction of metalloids with microbes and their impact on ecophysiology. 4. Unravels the mysteries of metalloid stress in plants by using multi-omics approaches. 5. Covers biological applications of metalloids in sustainable agricultural practices and in human health.This book is aimed to give updated and scientific insights to readers and researchers associated with plant stress physiology, agricultural sciences and environmentalists working for the well-being of the environment. Apart from these, the present book will also be boon for scientists, farmers, teachers and undergraduate and post graduate students as it provides a detailed account of distribution, biochemistry, detoxification mechanisms, and biological applications of metalloids.
Metalloids in Plants: Advances and Future Prospects
by Durgesh K. Tripathi Rupesh Deshmukh Gea GuerrieroUnderstanding metalloids and the potential impact they can have upon crop success or failure Metalloids have a complex relationship with plant life. Exhibiting a combination of metal and non-metal characteristics, this small group of elements – which includes boron (B), silicon (Si), germanium (Ge), arsenic (As), antimony (Sb), and tellurium (Te) – may hinder or enhance the growth and survival of crops. The causes underlying the effects that different metalloids may have upon certain plants range from genetic variance to anatomical factors, the complexities of which can pose a challenge to botanists and agriculturalists of all backgrounds. With Metalloids in Plants, a group of leading plant scientists present a complete guide to the beneficial and adverse impacts of metalloids at morphological, anatomical, biochemical, and molecular levels. Insightful analysis of data on genetic regulation helps to inform the optimization of farming, indicating how one may boost the uptake of beneficial metalloids and reduce the influence of toxic ones. Contained within this essential new text, there are: Expert analyses of the role of metalloids in plants, covering their benefits as well as their adverse effects Explanations of the physiological, biochemical, and genetic factors at play in plant uptake of metalloids Outlines of the breeding and genetic engineering techniques involved in the generation of resistant crops Written for students and professionals in the fields of agriculture, botany, molecular biology, and biotechnology, Metalloids in Plants is an invaluable overview of the relationship between crops and these unusual elements.
Metallointercalators
by Janice Aldrich-WrightA comprehensive treatment of the characterisation techniques used in investigating inorganic and organic molecules that interact with biomolecules is presented to the reader in a clear fashion. The work consists of two parts: (i) synthetic aspects of metallointercalators along with targeting and improving transport and (ii) the various techniques that are used for probing their interactions, such as; DNA-NMR, PGSE-NMR, DNA ESI-MS, Linear and Circular Dichroism, Fluorescence Spectroscopy, Confocal Microscopy, Viscosity, TGA and dialysis, Microarrays, biological analysis. Chapters are devoted to the synthesis and the techniques used to study the interactions of inorganic complexes with biomolecules. Considerably detailed examples are used to help illustrate the application of these techniques. This book is a useful resource for an array of inorganic and organic advanced undergraduate and graduate courses and for researchers in drug discovery.
Metallomics and the Cell
by Lucia BanciMetallomics and the Cell provides in an authoritative and timely manner in 16 stimulating chapters, written by 37 internationally recognized experts from 9 nations, and supported by more than 3000 references, several tables, and 110 illustrations, mostly in color, a most up-to-date view of the "metallomes" which, as defined in the "omics" world, describe the entire set of biomolecules that interact with or are affected by each metal ion. The most relevant tools for visualizing metal ions in the cell and the most suitable bioinformatic tools for browsing genomes to identify metal-binding proteins are also presented. Thus, MILS-12 is of relevance for structural and systems biology, inorganic biological chemistry, genetics, medicine, diagnostics, as well as teaching, etc.
Metallomics: Analytical Techniques and Speciation Methods
by Bernhard MichalkeLatest developments, new insights and knowledge derived from speciation analysis in one unique compilation: The reader gets acquainted with relevant instrumental as well as application aspects of metallomics approaches, paving the road to understanding fate, pathway, and action of metals in environment and organisms. Upon an introductory chapter on analytical methods and strategies, the full bandwidth of applications is discussed. Expert chapter authors cast spotlights on recent topics such as metallomics applications to environmental and nutrition studies as well as biology and medicine. Special chapters deal with the impact of manganese and iron on neurodegeneration, and the impact of nanoparticles on health.
Metallomics: The Science of Biometals (Advances in Experimental Medicine and Biology #1055)
by Marco Aurélio ArrudaThis book covers the new Omics area, Metallomics. As Metallomics is intrinsically a transdisciplinary area, this book is authored by experts in the field on such diverse topics as Environmental, Nuclear, and Human Metallomics. Within these topics metals play important role, as being part of biomolecules, controlling different biochemical process, being signaling agents, being catalyst of biochemical reactions, among others. This volume demonstrates the importance of more investigation about metals and their interactions with biomolecules. As the knowledge in this field is growing and growing daily, then new challenges concerning studies involving Metallomics is appearing, such as comparative metallomics, speciation metallomics, real-time metallomics, new predictions of metals in biomolecules, metalloprotein databank expansion, interactions between metalloprotein-metalloprotein, among others.
Metalloprotein Active Site Assembly
by Robert A. Scott Michael K. JohnsonSummarizes the essential biosynthetic pathways for assembly of metal cofactor sites in functional metalloproteins Metalloprotein Active Site Assembly focuses on the processes that have evolved to orchestrate the assembly of metal cofactor sites in functional metalloproteins. It goes beyond the simple incorporation of single metal ions in a protein framework, and includes metal cluster assembly, metal-cofactor biosynthesis and insertion, and metal-based post-translational modifications of the protein environments that are necessary for function. Several examples of each of these areas have now been identified and studied; the current volume provides the current state-of-the-art understanding of the processes involved. An excellent companion to the earlier book in this series Metals in Cells—which discussed both the positive and negative effects of cellular interactions with metals—this comprehensive book provides a diverse sampling of what is known about metalloprotein active site assembly processes. It covers all major biological transition metal components (Mn, Fe, Co, Ni, Mo), as well as the other inorganic components, metal-binding organic cofactors (e.g., heme, siroheme, cobalamin, molybdopterin), and post-translationally modified metal binding sites that make up the patchwork of evolved biological catalytic sites. The book compares and contrasts the biosynthetic assembly of active sites involving all biological metals. This has never been done before since it is a relatively new, fast-developing area of research. Metalloprotein Active Site Assembly is an ideal text for practitioners of inorganic biochemistry who are studying the biosynthetic pathways and gene clusters involved in active site assembly, and for inorganic chemists who want to apply the concepts learned to potential synthetic pathways to active site mimics.
Metalloproteins
by Juan C. Fontecilla-Camps Yvain NicoletMetalloproteins are involved in many key biological processes such as gas transport and metabolism, photosynthesis, cell respiration, the Krebs cycle and many other vital redox reactions. "Metalloproteins: Methods and Protocols" addresses multiple aspects of metalloenzyme research from the production and purification of metalloproteins using both standard recombinant techniques and a cell-free system, to the electrochemical analysis of metalloproteins, as well as IR techniques, Mossbauer spectroscopy and the theoretical interpretation of metalloenzyme catalytic and redox processes, to name a few topics. Written in the successful "Methods in Molecular Biology" series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, "Metalloproteins: Methods and Protocols" seeks to serve both professionals and novices interested in the metalloprotein field. "
Metalloproteins: Methods and Protocols (Methods in Molecular Biology #1876)
by Yilin HuThis volume provides an up-to-date, in-depth overview of the methods that have been applied to studying the complex metalloproteins at a molecular level. Chapters cover a wide range of approaches focusing on genetic, biochemical, spectroscopic, chemical methods, and theoretical calculations. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Metalloproteins: Methods and Protocols aims to be useful for anyone who is interested in metalloprotein research and wants to address the unanswered mechanistic and biosynthetic questions of these fascinating enzyme systems.
Metalloproteins: Theory, Calculations, and Experiments
by Art E. Cho William A. Goddard IIINumerous essential biological functions involve metalloproteins; therefore, understanding metalloproteins and how to manipulate them is significant in the biological and medical fields. An examination of current research, Metalloproteins: Theory, Calculations, and Experiments explores the interplay between theory and experiment, detailing the role
Metallosurfactants: From Fundamentals to Catalytic and Biomedical Applications
by Ravneet Kaur Surinder K MehtaMetallosurfactants Provides up-to-date coverage of the synthesis, properties, and applications of metallosurfactants Metallosurfactants: From Fundamentals to Catalytic and Biomedical Applications is a thorough introduction to amphiphilic compounds that allow to incorporate metal ions in the surfactant system. This comprehensive reference and guide describes the fundamentals of metal surfactant complexes, highlights recent advances in the field, and explores current and future applications and research areas. Gradually progressing from basic to advanced topics, the authors first explain the classification and characterization of metallosurfactants before delving into more complex concepts and various catalytic, sensing, and biomedical applications. The book begins with coverage of the synthesis of metallosurfactants and their surface, interfacial, and aggregation behavior. Subsequent chapters discuss applications of metallosurfactants in areas such as drug delivery, molecular machines, transfection, nanoparticle synthesis, and carbon monoxide-releasing molecules (CORMs). Other topics include the use of metallosurfactants as catalysts in organic reactions, and as anticancer and antimicrobial agents in drug delivery and formulation. This unique reference Provides an overview of the structure-function relationship, synthesis methods, and characterization of metallosurfactants Reviews current trends in metallosurfactant development and research Examines the use of metallosurfactants in a wide range of reactions, including esterolytic reactions and hydrogen generation Discusses advanced applications of metallosurfactants, e.g. as nanoreactors for nanoparticle synthesis, non-viral transfection vectors, and sensors Metallosurfactants: From Fundamentals to Catalytic and Biomedical Applications is an excellent introduction to the growing field of metallosurfactant chemistry as well as a concise, highly useful reference for researchers and scientists in both academia and industry.
Metallothioneins in Normal and Cancer Cells
by Piotr Dziegiel Bartosz Pula Christopher Kobierzycki Mariusz Stasiolek Marzenna Podhorska-OkolowThis book describes the structures of Metallothionein (MT) family members and the cellular functions of MT-1, MT-2 and MT-4 isoforms, as well as provides insights into divergent biological roles of MT-3. The authors explain the involvement of MT molecules in various processes related to carcinogenesis, including an organ-specific presentation of current data concerning their potential impact on the progression of various tumors and the regulatory role of MT family members in the function of the immune system.
Metallurgical Design and Industry: Prehistory to the Space Age
by Brett Kaufman Clyde L. BriantThis edited volume examines metallurgical technologies and their place in society throughout the centuries. The authors discuss metal alloys and the use of raw mineral resources as well as fabrication of engineered alloys for a variety of applications. The applications covered in depth include financial, mining and smelting, bridges, armor, aircraft, and power generation. The authors detail the multiple levels and scales of impact that metallurgical advances have had and continue to have on society. They include case studies with guidance for future research design and innovation of metallic materials relevant to societal needs.Includes case studies written by industry professionals with guidance for future research design and innovation;Demonstrates metal materials design that reflects relevant societal needs;Covers a broad range of applied materials used in aircraft, armor, bridges, and power generation, among others.
Metallurgy Fundamentals: Ferrous and Nonferrous
by Daniel A. Brandt and J.C. WarnerMetallurgy Fundamentals provides instruction on the basic properties, characteristics, and production of the major metal families. Clear, concise language and numerous illustrations make this an easy-to-understand text for an introductory course in metallurgy. Numerous full-color tables, diagrams, and photographs show both the theoretical and practical aspects of metallurgy.
Metallurgy and Corrosion Control in Oil and Gas Production
by Robert HeidersbachThis book is intended for engineers and related professionals in the oil and gas production industries. It is intended for use by personnel with limited backgrounds in chemistry, metallurgy, and corrosion and will give them a general understanding of how and why corrosion occurs and the practical approaches to how the effects of corrosion can be mitigated. It is also an asset to the entry-level corrosion control professional who may have a theoretical background in metallurgy, chemistry, or a related field, but who needs to understand the practical limitations of large-scale industrial operations associated with oil and gas production. While the may use by technicians and others with limited formal technical training, it will be written on a level intended for use by engineers having had some exposure to college-level chemistry and some familiarity with materials and engineering design.
Metallurgy and Corrosion Control in Oil and Gas Production (Wiley Series in Corrosion #8)
by Robert HeidersbachDetails the proper methods to assess, prevent, and reduce corrosion in the oil industry using today's most advanced technologies This book discusses upstream operations, with an emphasis on production, and pipelines, which are closely tied to upstream operations. It also examines protective coatings, alloy selection, chemical treatments, and cathodic protection—the main means of corrosion control. The strength and hardness levels of metals is also discussed, as this affects the resistance of metals to hydrogen embrittlement, a major concern for high-strength steels and some other alloys. It is intended for use by personnel with limited backgrounds in chemistry, metallurgy, and corrosion and will give them a general understanding of how and why corrosion occurs and the practical approaches to how the effects of corrosion can be mitigated. Metallurgy and Corrosion Control in Oil and Gas Production, Second Edition updates the original chapters while including a new case studies chapter. Beginning with an introduction to oilfield metallurgy and corrosion control, the book provides in-depth coverage of the field with chapters on: chemistry of corrosion; corrosive environments; materials; forms of corrosion; corrosion control; inspection, monitoring, and testing; and oilfield equipment. Covers all aspects of upstream oil and gas production from downhole drilling to pipelines and tanker terminal operations Offers an introduction to corrosion for entry-level corrosion control specialists Contains detailed photographs to illustrate descriptions in the text Metallurgy and Corrosion Control in Oil and Gas Production, Second Edition is an excellent book for engineers and related professionals in the oil and gas production industries. It will also be an asset to the entry-level corrosion control professional who may have a theoretical background in metallurgy, chemistry, or a related field, but who needs to understand the practical limitations of large-scale industrial operations associated with oil and gas production.
Metallurgy in Space: Recent Results from ISS (The Minerals, Metals & Materials Series)
by Hans-Jörg Fecht Markus MohrThis book presents experimental work conducted on the International Space Station (ISS) in order to characterize metals and alloys in the liquid state. The internationally recognized authors present and discuss experiments performed in microgravity that enabled the study of the relevant volume and surface related properties free of the restrictions of a gravity-based environment. The collection serves also as a handbook of space experiments using electromagnetic levitation techniques. A summary of recent results provides an overview of the wealth of space experiment data, which will ignite further research activities and inspire academics and industrial research departments for their continuous development.
Metals Ions in Biological System: Volume 39: Molybdenum and Tungsten: Their Roles in Biological Processes: (Metal Ions in Biological Systems)
by Astrid Sigel Helmut SigelVolume 39: Molybdenum and Tungsten: Their Roles in Biological Processes is devoted soley to the vital research area on molybdenum and tungsten and their role in biology. It offers a comprehensive and timely account of this fascinating topic by 40 distinguished international authorities. Topics include: transport, homeostasis, regulation and binding of molybdate and tungstate to proteins, crystallographic characterization, coordination of complexes, and biosynthesis.
Metals and How to Weld Them (second edition)
by T. B. JeffersonIn addition to the information a student would need in order to learn to be an arc welder, this book has an appendix with metallurgy terms. That and its detailed index make this a useful reference tool for those working in careers where welding is an essential skill. There are many different metals, and there is a science of welding. Not just any metals can be bonded together. Each metal has its own properties and uses. There is also a chapter on precious metals.
Metals and Metalloids in Plant Signaling (Signaling and Communication in Plants)
by Tariq AftabIn many parts of the world, soil and water are slightly to moderately contaminated with metals and metalloids such as Cd, Cu, Zn, Ni, Co, Cr, Pb, Si, B and As. This could be due to long-term use of phosphatic fertilizers, sewage sludge application, dust from smelters, industrial waste and bad watering practices in agricultural lands. Beside natural factors, human activities have contributed to the enormous increase in heavy metal and/or metalloid pollution in the environment. Metal and metalloid stress are major abiotic stress factors that limit crop production and reduce agricultural yield. The primary response of plants is the generation of reactive oxygen species (ROS) upon exposure to high levels of metals/metalloids. They either generate ROS directly through Haber-Weiss reactions or overproduction of ROS and occurrence of oxidative stress in plants could be the indirect consequence of metals/metalloids toxicity. The indirect mechanisms include their interaction with the antioxidant system, disrupting the electron transport chain or disturbing the metabolism of essential elements. One of the most deleterious effects induced by heavy metals exposure in plants is lipid peroxidation, which can directly cause biomembrane deterioration. The impact of metals/metalloids on plant water relations has to be distinguished from their effects on water availability in soils, on root growth, limiting water uptake, as well as other phytotoxic effects. If soils are high in soluble salts (including heavy metal salts), the osmotic potential in the soil solution might be lower than the potential of the cell sap in root. Under these circumstances, the soil solution would severely restrict the rate of water uptake by plants and lead to osmotic stress. Further, the negative influence metals/metalloids have on the growth and activities of soil microorganisms, may also indirectly affect the growth of plants. In the book “Metals and Metalloids in Plant Signaling”, we elucidated the effects of metals/metalloids on signaling and communication cascades in plants. The general aim of the present book is to provide a comprehensive analysis of the current situation and development in the field and to develop a science-based theoretical foundation for the conceptualization, and practical application. The various chapters are based on the consideration of metals/metalloids in terms of their action on different regulatory and functional systems of plants (signaling, metabolism, uptake, and transport mechanisms, etc.).
Metals and Non-metals: Five-membered N-heterocycle Synthesis
by Navjeet KaurDesign of new processes that avoid the use of toxic reagents has been the focus of intense research of late. Catalysis by metals and non-metals offers diverse opportunities for the development of new organic reactions with promising range of selectivities—chemoselectivity, regioselectivity, diastereoselectivity, and enantioselectivity. Furthermore, these transformations frequently occur under mild conditions, tolerate a broad array of functional groups, and proceed with high stereoselectivity. The area of catalysis is sometimes referred to as a ‘foundational pillar’ of green chemistry. Catalytic reactions often reduce energy requirements and decrease separations because of increased selectivity; they are also capable of permitting the use of renewable feedstocks of less toxic reagents or minimizing the quantities of reagents needed. New catalytic organic synthesis methodologies have, thus, offered several possibilities for considerable improvement in the eco-compatibility of fine chemical production. Hence, these catalytic methodologies have emerged as powerful tools for the efficient and chemoselective synthesis of heterocyclic molecules. Key Features: Presents the synthesis of different five-membered heterocycles. Contains the most up-to-date information in this fast-moving field. Covers novel catalytic approaches used in the study and application of catalysts in synthetic organic reactions. Presents new methodologies for the synthesis of heterocycles.
Metals and the Biology and Virulence of Brucella
by R. Martin Roop II Clayton C. CaswellThis book summarises the current knowledge on the role played by biologically relevant transition metals (Fe, Mn, Zn, Ni, Co, Cu and Mg) in the basic biology and virulence of bacterial pathogens from the genus Brucella. The authors explore the biological functions of these metals, how these bacteria compete with their mammalian hosts for these metals and how they avoid metal toxicity. Researchers and professionals studying zoonotic pathogens from the genus Brucella find this book valuable.