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Lynn Margulis: The Life and Legacy of a Scientific Rebel
by Dorion SaganTireless, controversial, and hugely inspirational to those who knew her or encountered her work, Lynn Margulis was a scientist whose intellectual energy and interests knew no bounds. Best known for her work on the origins of eukaryotic cells, the Gaia hypothesis, and symbiogenesis as a driving force in evolution, her work has forever changed the way we understand life on Earth.When Margulis passed away in 2011, she left behind a groundbreaking scientific legacy that spanned decades. In this collection, Dorion Sagan, Margulis's son and longtime collaborator, gathers together the voices of friends and colleagues to remark on her life and legacy, in essays that cover her early collaboration with James Lovelock, her fearless face-off with Richard Dawkins during the so-called "Battle of Balliol" at Oxford, the intrepid application of her scientific mind to the insistence that 9/11 was a false-flag operation, her affinity for Emily Dickinson, and more.Margulis was elected to the National Academy of Sciences in 1983, received the prestigious National Medal of Science in 1999, and her papers are permanently archived at the Library of Congress. Less than a month before her untimely death, Margulis was named one of the twenty most influential scientists alive - one of only two women on this list, which include such scientists as Stephen Hawking, James Watson, and Jane Goodall.&“Although she could be a bulldog, her heart was soft and her spirit loving beneath the scientific realpolitik of her conversation and the insistent tough-mindedness of her sometimes strident and blunt, withering and refreshingly unadorned opinions.&”—Dorion Sagan, from the introduction
Lyophilization: Introduction and Basic Principles
by Thomas A. JenningsFinding consistent, analytical discussions of processes and principles of lyophilization can be challenging and often frustrating. The first resource to gather information about the field, Lyophilization: Introduction and Basic Principles is still the book to have on lyophilization. Presenting information in an easy-to-read style, the book comprehe
Lyotropic Chromonic Liquid Crystals
by Shuang ZhouThis thesis describes lyotropic chromonic liquid crystals (LCLCs) with exotic elastic and viscous properties. The first part of the thesis presents a thorough analysis of the elastic and viscous properties of LCLCs as functions of concentration, temperature and ionic contents, while the second part explores an active nematic system: living liquid crystals, which represent a combination of LCLC and living bacteria. LCLCs are an emerging class of liquid crystals that have shown profound connections to biological systems in two aspects. First, the assembly process of the chromonic aggregates is essentially the same as DNA oligomers and other super-molecular assemblies of biological origin. LCLCs thus provide an excellent model system for studying physical properties such as the elasticity and viscosity of these supramolecular assemblies. Second, LCLCs are biocompatible, thus serving as a unique anisotropic matrix to interface with living systems such as bacteria. This thesis deepens our understanding of both aspects. The noncovalent nature of chromonic aggregation produces the unique viscoelasticity to be found in LCLCs, which differs dramatically from that of traditional LCs. Anisotropic interactions between LCLCs and bacteria lead to fascinating phenomena such as the deformation of LCLCs with a characteristic wavelength determined by the elasticity of the LCLCs and the activity of the bacteria, orientationally controlled trajectories of bacteria and visualization of 24 nm flagella motion.
The Lyotropic State of Matter: Molecular Physics and Living Matter Physics
by Alexander G PetrovThe lyotropic state of matter embraces highly concentrated solutions of soaps and detergents, as well as such biologically active substances as lipids, proteins, nucleic acids and lipopolysaccharides. Since some of the most important living lyotropic structures are biological membranes, their study is multidisciplinary, ranging from the molecular physics and physical chemistry of interfaces to living matter physics in general, and membrane biophysics in particular. Written for liquid crystal scientists who are not familiar with lyotropics and membranes, for membranologists who are not familiar with liquid crystal physics, and for experts in these fields, The Lyotropic State of Matter: Molecular Physics and Living Matter Physics presents both theory and experiment, and provides an overview of the state of the art in this exciting area of study.
The Lysenko Controversy as a Global Phenomenon, Volume 1
by William Dejong-Lambert Nikolai KrementsovThis volume covers the global history of the Lysenko controversy, while exploring in greater depth the background of D. Lysenko's career and influence in the USSR. By presenting the rise and fall of T. D. Lysenko in a variety of aspects--his influence upon art, unrecognized predecessors, and the extent to which genetics continued in the USSR even while he was in power, and the revival of his reputation today--the authors provide a fresh perspective on one of the most notorious episodes in the history of science.
The Lysenko Controversy as a Global Phenomenon, Volume 2
by William Dejong-Lambert Nikolai KrementsovThis volume examines the international impact of Lysenkoism in its namesake's heyday and the reasons behind Lysenko's rehabilitation in Russia today. By presenting the rise and fall of T. D. Lysenko in its various aspects, the authors provide a fresh perspective on one of the most notorious episodes in the history of science.
Lysenko's Ghost: Epigenetics and Russia
by Loren GrahamLysenko became one of the most notorious figures in twentieth-century science after his genetic theories were discredited decades ago. Yet some scientists now claim that discoveries in epigenetics prove that he was right after all. Loren Graham reopens the case, to determine whether new developments in molecular biology validate Lysenko's claims.
Lysophospholipid Receptors
by Wouter Moolenaar Timothy Hla Sarah Spiegel Jerold ChunThe current state of the science supporting new research in lysophospholipidsThe study of lysophospholipids exploded with the discovery of cell surface receptors on both lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P). Since then, thousands of original research reports-ranging from fundamental cell signaling to the physiology and pathophysiology of individual organ systems-have centered on lysophospholipids. This book draws together and analyzes the current literature to provide readers with a state-of-the-science review as well as current techniques that support research in all aspects of the field of lysophospholipid signaling.Lysophospholipid Receptors is divided into three sections:Receptors and other possible effectorsEnzymesPhysiology and pathophysiologyWithin each section, the authors explain the similarities and differences between LPA and S1P signaling. Examples are provided that demonstrate the underlying mechanisms of lysophospholipid signaling across a broad range of organ systems, such as S1P signaling in cardiovascular physiology and disease and the neural effects of LPA signaling. Extensive references at the end of each chapter provide a gateway to the literature and facilitate further research into individual topics.Each chapter has been authored by one or more leading international authorities in lysophospholipid research. Based on a thorough analysis of the current research, the authors set forth what is established science and offer their expert opinion and perspective on new and emerging areas of research, setting the stage for further investigations that will solve current problems in the field.
Lysosomal Pathways of Protein Degradation
by J Fred DiceLysosomal Pathways of Protein Degradation looks at cell biology from the view of a lysosome. It summarizes the composition and assembly of lysosomes in mammalian and yeast cells. It also reviews current knowledge about pathways of endocytosis and secretion and how both endocytosed and secreted proteins can be delivered to lysosomes for degradation.
Lysosomes: Biology, Diseases, and Therapeutics
by Shuyan Lu James M. Willard Frederick R. MaxfieldDiscussing recent findings, up-to-date research, and novel strategies, the book integrates perspectives from pharmacology, toxicology, and biochemistry to illustrate the potential of lysosomes in drug discovery and development.* Explores basic principles and properties of lysosomes that allow them to act as regulators of cell metabolism, therapeutic targets, and sites for activation of drug conjugates * Discusses the role of lysosomes in metabolism, drug targeting, apoptosis, cancer, aging, inflammation, autophagy, metabolism, toxicity, and membrane repair* Introduces new pathways in therapeutic development and new mechanisms in drug development
Lysosomes
by Karin Öllinger Hanna AppelqvistThis volume provides laboratory protocols essential for studies on lysosomal biology. Chapters aim to guide researchers in their exploration of lysosomes, both under normal conditions and in pathological processes. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Lysosome: Methods and Protocols aims to provided protocols that will guide and inspire further research and generate new insights into this fascinating organelle.
m-Health: Fundamentals and Applications
by Robert S. Istepanian Bryan WoodwardThis book introduces the concept of m-Health, first coined by Robert S. H. Istepanian in 2003. The evolution of m-Health since then--how it was transformed from an academic concept to a global healthcare technology phenomenon--is discussed. Afterwards the authors describe in detail the basics of the three enabling scientific technological elements of m-Health (sensors, computing, and communications), and how each of these key ingredients has evolved and matured over the last decade. The book concludes with detailed discussion of the future of m-Health and presents future directions to potentially shape and transform healthcare services in the coming decades.
m-Mode SVPWM Technique for Power Converters (CPSS Power Electronics Series)
by Bo Zhang Dongyuan QiuThis book presents a novel control method for power converters, referred to as m-mode control. It provides an overview of traditional control methods for inverters – e.g. PWM and SVPWM – and the theory of the m-mode control method, while also discussing and applying m-mode control on various types of converters (including three-phase, nine-switch, five-leg and multi-level inverters, PWM rectifiers and modular multi-level converters). The book provides readers with sufficient background and understanding to delve deeper into the topic of SVPWM control. It is also a valuable guide for engineers and researchers whose work involves power converter control.
M² Models and Methodologies for Community Engagement
by Reena Tiwari Marina Lommerse Dianne SmithHow can we engage communities? What is empowerment? To what extent should the project process be participatory? How is an outsider-insider relationship handled? How do researchers negotiate with the hegemony of western cultural interpretations? How are organizational and contextual influences handled in a project? What leadership demands do such projects place on researchers? What is capacity building? What are creative leaders and creative communities? How does the researcher journey from their studio to the situation? M² Models and Methodologies for Community Engagement discusses key theoretical constructs -- community engagement, capacity building, and community empowerment -- in order to demonstrate how theory and practice are relevant to the development of forms of community involvement. The book maps the attributes of community based projects by moving beyond simply bringing people together from a variety of disciplines, and taking an approach which is transdisciplinary and applicable across cultures and genres. Here, all people -- including the community -- are ongoing contributors, and can freely move between their own and others' discipline-specific arenas. M² differs from and extends on other works in this field of practice and research, in that its transdisciplinary, collaborative approach positions the community as a particular kind of discipline to create real change in diverse locations and fields of experience. The book is in itself a model of community engagement, as the researchers have formed a community of research and practice for change, and have developed a transformative model for community engagement that is greater than the sum of its parts - hence M². M² offers a valuable resource for students, researchers, academics, practitioners, policy developers and volunteers from the fields of architecture, interior architecture, health, planning, anthropology, education, home economics, communication, political studies and development studies.
The M2 Macrophage (Progress in Inflammation Research #86)
by Tamás RöszerMacrophages are core components of the innate immune system. Once activated, they may have either pro- or anti-inflammatory effects that include pathogen killing, safe disposal of apoptotic cells or tissue renewal. The activation state of macrophages is conceptualized by the so-called M1/M2 model of polarization. M2 macrophages are not simply antagonists of M1 macrophages; rather, they represent a network of tissue resident macrophages with roles in tissue development and organ homeostasis. M2 macrophages govern functions at the interfaces of immunity, tissue development and turnover, metabolism, and endocrine signaling. Dysfunction in M2 macrophages can ruin the healthy interplay between the immune system and metabolic processes, and lead to diseases such as insulin resistance, metabolic syndrome, and type 1 and 2 diabetes mellitus. Furthermore, M2 macrophages are essential for healthy tissue development and immunological self-tolerance. Worryingly, these functions of M2 macrophages can also be disrupted, resulting in tumor growth and autoimmunity. This book comprehensively discusses the biology of M2 macrophages, summarizes the current state of knowledge, and highlights key questions that remain unanswered.
M3 and M5 Stuart Light Tank, 1940-45
by Steven J. ZalogaThe M3 and M5 family of light tanks were the culmination of American tank development of the 1930s. By the time of the outbreak of the World War II, they were approaching obsolescence, as tank forces in Europe were shifting from light to medium tanks as the main element of their armored forces. First entering combat in the autumn of 1941 in the Western Desert with the British Army, the Stuart quickly proved its inadequacies. The M3 and M5 light tanks proved more suitable in the Pacific theater than in Europe, and fought successfully in many of the major battles including Guadalcanal, Tarawa and Peleliu. This title narrates this distinctive and unusual fighting vehicle's history.
M8.0 Wenchuan Earthquake
by Huilin Xing Xiwei XuThe M8.0 Wenchuan Earthquake occurred in China on May 12, 2008, killing over 69,000 people and displacing millions from their homes. This was one of the most catastrophic natural disasters on record. This book includes 5 chapters describing the tectonic setting and historical earthquakes around the Chuan-Dian region, the nucleation of the Wenchuan earthquake, occurrence and aftershocks. The field observations of earthquake induced surface fractures and building damage, form a major and special part of this book and include a large number of digital photos with accompanying explanantions.
MAC Protocols for Cyber-Physical Systems
by Feng Xia Azizur RahimThis book provides a literature review of various wireless MAC protocols and techniques for achieving real-time and reliable communications in the context of cyber-physical systems (CPS). The evaluation analysis of IEEE 802. 15. 4 for CPS therein will give insights into configuration and optimization of critical design parameters of MAC protocols. In addition, this book also presents the design and evaluation of an adaptive MAC protocol for medical CPS, which exemplifies how to facilitate real-time and reliable communications in CPS by exploiting IEEE 802. 15. 4 based MAC protocols. This book will be of interest to researchers, practitioners, and students to better understand the QoS requirements of CPS, especially for healthcare applications.
The Macaque Connection
by Anindya Sinha Michael A. Huffman Sindhu RadhakrishnaThe concept of this book arises from a symposium entitled "Human-Macaque Interactions: Traditional and Modern Perspectives on Cooperation and Conflict " organized at the 23rd Congress of the International Primatological Society, that was held in Kyoto in September 2010. The symposium highlighted the many aspects of human-macaque relations and some of the participants were invited to contribute to this volume. The volume will include about 11 chapters by a variety of international authors and some excerpts from published literature that illustrate cultural notions of macaques. Contributions from invited authors will engage with four main perspectives - traditional views of macaques, cooperative relationships between humans and macaques, current scenarios of human-macaque conflict, and how living with and beside humans has affected macaques. Authors will address these concerns through their research findings and reviews of their work on the Asian, and the lone African, macaques.
Machine and Deep Learning in Oncology, Medical Physics and Radiology
by Issam El Naqa Martin J. MurphyThis book, now in an extensively revised and updated second edition, provides a comprehensive overview of both machine learning and deep learning and their role in oncology, medical physics, and radiology. Readers will find thorough coverage of basic theory, methods, and demonstrative applications in these fields. An introductory section explains machine and deep learning, reviews learning methods, discusses performance evaluation, and examines software tools and data protection. Detailed individual sections are then devoted to the use of machine and deep learning for medical image analysis, treatment planning and delivery, and outcomes modeling and decision support. Resources for varying applications are provided in each chapter, and software code is embedded as appropriate for illustrative purposes. The book will be invaluable for students and residents in medical physics, radiology, and oncology and will also appeal to more experienced practitioners and researchers and members of applied machine learning communities.
Machine and Sovereignty: For a Planetary Thinking
by Yuk HuiDeveloping a new political thought to address today&’s planetary crises What is &“planetary thinking&” today? Arguing that a new approach is urgently needed, Yuk Hui develops a future-oriented mode of political thought that encompasses the unprecedented global challenges we are confronting: the rise of artificial intelligence, the ecological crisis, and intensifying geopolitical conflicts. Machine and Sovereignty starts with three premises. The first affirms the necessity of developing a new language of coexistence that surpasses the limits of nation-states and their variations; the second recognizes that political forms, including the polis, empire, and the state, are technological phenomena, which Lewis Mumford terms &“megamachines.&” The third suggests that a particular political form is legitimated and rationalized by a corresponding political epistemology. The planetary thinking that this book sketches departs from the opposition between mechanism and organism, which characterized modern thought, to understand the epistemological foundations of Hegel&’s political state and Schmitt&’s Großraum and their particular ways of conceiving the question of sovereignty. Through this reconstruction, Hui exposes the limits of the state and reflects on a new theoretical matrix based on the interrelated concepts of biodiversity, noodiversity, and technodiversity. Arguing that we are facing the limit of modernity, of the eschatological view of history, of globalization, and of the human, Hui conceives necessary new epistemological and technological frameworks for understanding and rising to the crises of our present and our future. Retail e-book files for this title are screen-reader friendly.
Machine Ethics and Robot Ethics
by Wendell Wallach and Peter AsaroOnce the stuff of science fiction, recent progress in artificial intelligence, robotics, and machine learning means that these rapidly advancing technologies are finally coming into widespread use within everyday life. Such rapid development in these areas also brings with it a host of social, political and legal issues, as well as a rise in public concern and academic interest in the ethical challenges these new technologies pose. This volume is a collection of scholarly work from leading figures in the development of both robot ethics and machine ethics; it includes essays of historical significance which have become foundational for research in these two new areas of study, as well as important recent articles. The research articles selected focus on the control and governance of computational systems; the exploration of ethical and moral theories using software and robots as laboratories or simulations; inquiry into the necessary requirements for moral agency and the basis and boundaries of rights; and questions of how best to design systems that are both useful and morally sound. Collectively the articles ask what the practical ethical and legal issues, arising from the development of robots, will be over the next twenty years and how best to address these future considerations.
Machine Intelligence and the Imaginal Realm: Spiritual Freedom and the Re-animation of Matter
by Luke Lafitte• Explores how we naturally project consciousness onto machines and how this is reflected in human culture, science, artificial intelligence, and literature • Demonstrates a direct connection between consciousness and the history of machines in American history • Looks at the contributions and influence of Grace Hopper, Richard Feynman, Philip K. Dick, Nikola Tesla, Thomas Edison, Elon Musk, David Bohm, Norbert Wiener, and Steve Jobs as well as the Nag Hammadi Gnostic gospels Humans invented and constructed machines to aid them, as far back as the Stone Age. As the machines became more complex, they became extensions of the body and mind, and we naturally began projecting consciousness onto them. As Luke Lafitte shows in detail, although machines complicate the already complicated issue of identity, because they are &“ours&” and &“of us,&” they are part of our spiritual development. In this sweeping exploration of the history of the machine as a tool, as a transpersonal object to assist human activity, and as a transitional artifact between spirits and the humans who interact with them, Lafitte examines the role that machines play in the struggle between &“spiritual man&” and &“mechanical man&” throughout history. He interprets the messages, archetypes, and language of the unconscious in the first popular stories related to mechanical men, and he demonstrates a direct connection between consciousness and the history of machines in American history, specifically between the inventors of these machines and the awakening of our imaginations and our powers of manifestation. He examines the influence of Philip K. Dick, Nikola Tesla, Thomas Edison, Grace Hopper, Richard Feynman, Elon Musk, David Bohm, and others and shows how the Nag Hammadi gospels explain how we can take back our myth and spirit from the machine. Although the term &“mechanical man&” is a catch-all phrase, Lafitte shows that the term is also a meeting ground where extra-dimensional communications between different forms of matter occur. Every machine, android, robot, and cyborg arose from consciousness, and these mechanical men, whether real or fictive, offer us an opportunity to free ourselves from enslavement to materialism and awaken our imaginations to create our own realities.
Machine Learning: Theory to Applications
by Seyedeh Leili Mirtaheri Reza ShahbazianThe book reviews core concepts of machine learning (ML) while focusing on modern applications. It is aimed at those who want to advance their understanding of ML by providing technical and practical insights. It does not use complicated mathematics to explain how to benefit from ML algorithms. Unlike the existing literature, this work provides the core concepts with emphasis on fresh ideas and real application scenarios. It starts with the basic concepts of ML and extends the concepts to the different deep learning algorithms. The book provides an introduction and main elements of evaluation tools with Python and walks you through the recent applications of ML in self-driving cars, cognitive decision making, communication networks, security, and signal processing. The concept of generative networks is also presented and focuses on GANs as a tool to improve the performance of existing algorithms. In summary, this book provides a comprehensive technological path from fundamental theories to the categorization of existing algorithms, covers state-of-the-art, practical evaluation tools and methods to empower you to use synthetic data to improve the performance of applications.
Machine Learning and Deep Learning in Efficacy Improvement of Healthcare Systems (Emerging Trends in Biomedical Technologies and Health informatics)
by Om Prakash JenaThe goal of medical informatics is to improve life expectancy, disease diagnosis and quality of life. Medical devices have revolutionized healthcare and have led to the modern age of machine learning, deep learning and Internet of Medical Things (IoMT) with their proliferation, mobility and agility. This book exposes different dimensions of applications for computational intelligence and explains its use in solving various biomedical and healthcare problems in the real world. This book describes the fundamental concepts of machine learning and deep learning techniques in a healthcare system. The aim of this book is to describe how deep learning methods are used to ensure high-quality data processing, medical image and signal analysis and improved healthcare applications. This book also explores different dimensions of computational intelligence applications and illustrates its use in the solution of assorted real-world biomedical and healthcare problems. Furthermore, it provides the healthcare sector with innovative advances in theory, analytical approaches, numerical simulation, statistical analysis, modelling, advanced deployment, case studies, analytical results, computational structuring and significant progress in the field of machine learning and deep learning in healthcare applications. FEATURES Explores different dimensions of computational intelligence applications and illustrates its use in the solution of assorted real-world biomedical and healthcare problems Provides guidance in developing intelligence-based diagnostic systems, efficient models and cost-effective machines Provides the latest research findings, solutions to the concerning issues and relevant theoretical frameworks in the area of machine learning and deep learning for healthcare systems Describes experiences and findings relating to protocol design, prototyping, experimental evaluation, real testbeds and empirical characterization of security and privacy interoperability issues in healthcare applications Explores and illustrates the current and future impacts of pandemics and mitigates risk in healthcare with advanced analytics This book is intended for students, researchers, professionals and policy makers working in the fields of public health and in the healthcare sector. Scientists and IT specialists will also find this book beneficial for research exposure and new ideas in the field of machine learning and deep learning.