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Mammalian Brain Development
by Damir JanigroThis book fills a gap in developmental books dealing with the normal prenatal mammalian brain. Most books that approach this topic work with non-human, non-vertebrate models. Mammalian Brain Development focuses on both the pre-natal and the peri-natal events that lead to brain damage as seen in the prospective of medical and research professionals, as well as examining the traditional "nature versus nurture" argument in the spectrum of brain development. The major topics addressed, in detail, in the book are sexual dimorphism, epigenetic action of gonadal hormones, environmental "programming" effects, autism, developmental learning disorders, seizures, and the etiopathogenesis of epileptic syndromes in young humans. The book also covers the general aspects of postnatal and pediatric neurological disorders in a unique and novel way by offering definitions of heredity, inheritance, genetic-epigenetic, genomic, molecular, developmental, and innate aspects of the mammalian brain in regards to its development.
Mammalian Cell Cultures for Biologics Manufacturing
by Weichang Zhou Anne KantardjieffVolumes are organized topically and provide a comprehensive discussion of developments in the respective field over the past 3-5 years. The series also discusses new discoveries and applications. Special volumes are dedicated to selected topics which focus on new biotechnological products and new processes for their synthesis and purification. In general, special volumes are edited by well-known guest editors. The series editor and publisher will however always be pleased to receive suggestions and supplementary information. Manuscripts are accepted in English.
Mammalian Cell Viability
by Martin J. StoddartWhether the question is one of basic cell survival, or whether it is being used to correlate cell number to some other factor such as matrix synthesis, an estimate of cell viability is universally required. In Mammalian Cell Viability: Methods and Protocols, experts in the field describe methods from the most basic which can be performed in any laboratory, to some which require specific pieces of equipment. Initially focusing on methods for monolayer and suspension cells, later chapters describe methods for determining viability within tissue sections and 3 dimensional culture systems. Finally, methods requiring highly specialized equipment are described in order to explain what is possible. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and vital tips on troubleshooting and avoiding known pitfalls. Practical and adaptable, Mammalian Cell Viability: Methods and Protocols serves as a self-contained laboratory manual useful to both experienced researchers and those new to this incredibly important and influential field.
Mammalian Chromosome Engineering
by Gyula HadlaczkyThe rapid progression of genetics and molecular biology has turned chromosomal engineering from science fiction to reality, with the successful production of transgenic animals with engineered chromosomes and chromosomes developed for pharmaceutical protein production which are now ready for the medical industry. Mammalian Chromosome Engineering: Methods and Protocols provides the reader with up-to date information on this rapidly evolving field and strives to take the reader into the exciting realm of chromosomal engineering from the basic principles to the practical applications of these new technologies. The five overview and ten protocol chapters cover the engineering of chromosomes with extrachromosomal vectors and transposon systems, the manipulation of naturally occurred minichromosomes, the generation and engineering of synthetic artificial chromosomes, and the induced de novo platform artificial chromosome system. Written in the highly successful Methods in Molecular BiologyTM series format, protocols chapters contain brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Mammalian Chromosome Engineering: Methods and Protocols serves as a bench-side resource for current protocols and aims to help scientists to explore the many prospects for future research and vital applications.
Mammalian Egg Transfer
by Lewis AdamsEgg transfer was first performed in 1890, but for half a century it received scant attention. However, since 1950 the technique has become increasingly widely used - in the laboratory for fundamental studies and more recently in practice, both veterinary and medical, to boost reproductive potential of genetically superior cattle and to overcome sterility due to impaired rubal function in women. As a result, a considerable body of literature has accumulated, totaling well in excess of a thousand references. But till now there has not been a single comprehensive text devoted solely to this subject. The present work was designed to meet that need at a time when the field is fast expanding with new techniques and approaches constantly being evolved. One need only cite the tremendous rate of progress in human egg transfer in the last three years. The work embraces laboratory and farm animals and primates, including man, altogether representing a total of 16 species.
Mammalian Endocrinology and Male Reproductive Biology
by Shio Kumar SinghMammalian Endocrinology and Male Reproductive Biology provides comprehensive and current coverage of the area of endocrinology and male reproductive biology, covering not just humans, but mammals in general. Written by international experts in their respective fields, this multi-author book also covers the latest developments in genomics of androge
Mammalian Heme Peroxidases: Diverse Roles in Health and Disease (Oxidative Stress and Disease #47)
by Clare L. HawkinsMammalian heme peroxidase enzymes play a critical role in innate immune responses and disease prevention. The formation of potent chemical oxidants is essential to this protective physiologic activity in immunity. Although highly beneficial in the context of immune defense, it is now well established that peroxidases and their overproduction of oxidants contribute to the initiation and persistence of many chronic inflammatory conditions in the cardiovascular, neurologic, respiratory, renal, and gastrointestinal systems. Peroxidasins, a protein family related to heme peroxidases, play a novel role in tissue biogenesis and matrix assembly, which are also attracting attention in different pathological contexts. Given the diverse roles of mammalian heme peroxidases and the breadth and incidence of pathologies associated with these enzymes, there has been significant interest in modulating peroxidase activity as a therapeutic strategy. This book highlights recent developments in our understanding of the chemistry, biochemistry and biological roles of mammalian peroxidases and their associated oxidants, their involvement in both innate immunity and chronic inflammatory disease in a variety of end organs, and potential therapeutic approaches to modulate and prevent damaging reactions. Key Features Structure and biosynthesis of mammalian peroxidases Reactivity of hypohalous acids with biological substrates Peroxidases in innate immunity Peroxidases in human pathology Modulation of peroxidase-induced biological damage
The Mammalian Jaw
by Walter Stalker GreavesMammalian skull structure is notably diverse; however at a basic level the jaw mechanism is remarkably similar, if not essentially the same, in the majority of mammals. Using simple models that are compared with real animals at every step, this book examines the basic structural features of the mammalian jaw mechanism from a mechanical point of view. It explores how the mechanical constraints placed on the jaw have contributed to the evolution of an efficient basic structure, used by many mammals, which precludes mechanical difficulties and uses a minimum amount of bone tissue. Throughout the book the emphasis is on conceptual understanding, with explanations linked together to form a complete story that can be applied to both fossil and extant mammals. Summarising over forty years of research from one of the leading pioneers in 3D jaw mechanics, this is a must-have for anyone interested in mammalian jaw morphology.
Mammalian Neuroendocrinology
by Paul V. MalvenMammalian Neuroendocrinology presents a concise examination of how the nervous and endocrine systems interact to regulate physiological processes. Selected experimental results are presented to illustrate the current understanding of neuroendocrine processes. Neural influences and endocrine feedback mechanisms related to the secretion of adenohypophysial hormones are summarized for each hormone. The book's concise nature and readable style are highly suited for use as a graduate textbook.There are also chapters devoted to each of the following topics: neurohypophysis, pineal gland, adrenal medulla, hormones and behavior, and neuroendocrine immunology. Comparisons are made among species of mammals, including laboratory rodents, domesticated ungulates, and primates. Agricultural and/or clinical aspects relevant to these topics are covered when appropriate. Mammalian Neuroendocrinology is excellent for students and professionals in neuroendocrinology, neuroscience, endocrinology, reproduction studies, and animal sciences.
Mammalian Oocyte Regulation
by Hayden A. HomerMammalian oocytes occupy a critical nexus in reproduction as they not only contribute half the genetic makeup of the embryo but also provide virtually all of the cytoplasmic building blocks required for sustaining embryogenesis. The journey that transforms a primordial germ cell into a mature oocyte (or egg) capable of fertilisation and embryonic development is of unrivalled complexity. The end-product of this remarkable developmental process is the "mature" egg, now replete with macromolecules and organelles, and poised to support embryonic development if fertilisation should occur. Given the importance of the oocyte for embryonic development, it is of no surprise that the oocyte holds centre stage in fertility clinics and greatly influences the outcome of assisted reproductive treatments (ARTs). Mammalian Oocyte Regulation: Methods and Protocols provides a highly diverse compendium of detailed methodologies - primarily focusing on the murine model but also including chapters on human oocytes - for enabling researchers to interrogate every aspect of mammalian oocyte development including recombination, meiotic maturation, oocyte substrate uptake, chromosomal segregation and fertilisation. Written in the highly successful Methods in Molecular BiologyTM series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Mammalian Oocyte Regulation: Methods and Protocols serves as an ideal guide to novice oocyte researchers, experts who wish to add another dimension to their established portfolio, as well as the wider research community.
Mammalian Paleoecology: Using the Past to Study the Present
by Felisa A. SmithWhat can the interactions of ancient mammals and their environments tell us about the present—and the future?Classic paleontology has focused on the study of fossils and the reconstruction of lineages of extinct species. But as diverse fossils of animals and plants were unearthed and catalogued, it became possible to reconstruct more elaborate ecosystems, tying together plants, animals, and geology. By the second half of the twentieth century, this effort gave birth to the field of paleoecology: the study of the interactions between organisms and their environments across geologic timescales. In Mammalian Paleoecology, Felisa Smith broadly considers extinct mammals in an ecological context. Arguing that the past has much to teach us and that mammals, which display an impressive array of diverse life history and ecological characteristics, are the ideal organism through which to view the fossil record, Smith• reviews the history, major fossil-hunting figures, and fundamental principles of paleoecology, including stratigraphy, dating, and taphonomy• discusses the importance of mammal body size, how to estimate size, and what size and shape reveal about long-dead organisms• explains the structure, function, and utility of different types of mammal teeth• highlights other important methods and proxies used in modern paleoecology, including stable isotopes, ancient DNA, and paleomidden analyses• assesses nontraditional fossils• presents readers with several case studies that describe how the fossil record can help inform the scientific discussion on anthropogenic climate changeMammalian Paleoecology is an approachable overview of how we obtain information from fossils and what this information can tell us about the environments of the distant past. It will profoundly affect the way paleontologists and climatologists view the lives of ancient mammals.
Mammalian Sterols: Novel Biological Roles of Cholesterol Synthesis Intermediates, Oxysterols and Bile Acids
by Damjana Rozman Rolf GebhardtThis book provides a comprehensive description of sterols and their novel biological roles in mammalian signaling, the book covers their biosynthesis and structure, describes sterol receptor -mediated actions, their tissue distribution and their role in disease. It offers insight into new research findings, focusing specifically on novel discoveries in bile acid and oxysterol signaling, including the lanosterol-to-cholesterol intermediates. Special attention is paid on the sex distribution of these sterols (male or female) and their sexually dimorphic roles in mammalian species, such as human, rat and mouse. Since sterols and drugs (xenobiotics) use many identical receptor-mediated signaling pathways, the book will be interesting for researchers working on the cross-road of endogenous and xenobiotic metabolism, it is intended for advanced students and scientists in molecular biology and biochemistry as well as for medical doctors in hepatology.
Mammalian Synthetic Promoters (Methods in Molecular Biology #1651)
by David GouldThis volume details methods that will aid in the selection of promoter sequences and vector components and methods for the assembly and testing of synthetic promoters with examples of their application. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Mammalian Synthetic Promoters: Methods and Protocols aims to aid researchers that are new to the field of synthetic promoters and inspire new developments.
Mammalian Synthetic Systems (Methods in Molecular Biology #2774)
by Francesca Ceroni Karen PolizziThis volume details cutting-edge methods that enables engineering of novel functions in mammalian cells. Chapters guide readers through cell-to-cell communication, cell fate control, protein and RNA-based biosensors together with tools for more reliable and faster mammalian genome editing. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Mammalian Synthetic Systems aims to ensure successful results in the further study of this vital field.
Mammalian Toxicology
by Mohamed Abou-DoniaMammalian Toxicology surveys chemical agents and examineshow such chemicals impact on human health, emphasizing theimportance in minimizing environmental exposure to chemical andphysical hazards in our homes, communities and workplaces throughsuch media as contaminated water, soil and air.Starting with the basic principles on a wide range of toxicagents, this textbook describes how they enter the body, theirmechanisms of action once inside, and strategies for diagnosis,prevention and treatment.Topics covered include:General principles of toxicology: pharmacological andtoxicological principles underpinning the study of toxicology, risk assessments and mechanisms of cell deathDisposition: routes of chemical exposures, entry intothe body and various tissues, storage, metabolic biotransformationand elimination, with examples from various toxicants.Toxic agents: the occurrences, disposition in the body,health effects, toxic mechanisms, antidotes and treatments of arange of agents including pesticides, metals, solvents, gases,nanomaterials, food components and additives, pharmaceuticals,drugs of abuse, natural toxins, endocrine disruptors, radiation,and warfare weapons. Toxic effects: including neurotoxicity, developmentaltoxicity, immunotoxicity, teratogenecity, male and femalereproductive toxicity, mutagenecity, carcinogenicity, pulmonary toxicity, cardiovascular toxicity, hepatotoxicity,gastrointestinal toxicity and cardiovascular toxicityToxicology and society: epidemiological studies ofchemical-induced diseases in human populations, and a vision fortoxicology in the 21st century.Mammalian Toxicology is an essential primer for studentsof toxicology, biochemistry, biology, medicine and chemistry. It isalso appropriate for professional toxicologists in research orregulatory affairs, and anyone who needs to understand the adverseeffects of toxic agents on the human body.
Mammalian Transient Receptor Potential (TRP) Cation Channels
by Veit Flockerzi Bernd NiliusIn this fast moving field the main goal of this volume is to provide up-to-date information on the molecular and functional properties and pharmacology of mammalian TRP channels. Leading experts in the field will describe properties of a single TRP protein/channel or portray more general principles of TRP function and important pathological situations linked to mutations of TRP genes or their altered expression. Thereby this volume on Transient Receptor Potential (TRP) Channels provides valuable information for readers with different expectations and backgrounds, for those who are approaching this field of research as well as for those wanting to make a trip to TRPs.
Mammalogy Techniques Lab Manual
by James M. RyanGet outside! A hands-on lab manual for instructors incorporating fieldwork into their courses on mammalogy.Mammals inhabit nearly every continent and every sea. They have adapted to life underground, in the frozen Arctic, the hottest deserts, and every habitat in-between. In Mammalogy Techniques Lab Manual—the only field manual devoted to training the next generation of mammalogists—biologist and educator James M. Ryan details the modern research techniques today’s professionals use to study mammals wherever they are found.Ideal for any mammalogy or wildlife biology course, this clear and practical guide aids students by getting them outside to study mammals in their natural environments. Twenty comprehensive chapters cover skull and tooth identification, radio and satellite GPS tracking, phylogeny construction, mark and recapture techniques, camera trapping, museum specimen preparation, optimal foraging, and DNA extraction, among other topics. Each chapter includes several exercises with step-by-step instructions for students to collect and analyze their own data, along with background information, downloadable sample data sets (to use when it is not practical to be out in the field), and detailed descriptions of useful open-source software tools.This pragmatic resource provides students with real-world experience practicing the complex techniques used by modern wildlife biologists. With more than 60 applied exercises to choose from in this unique manual, students will quickly acquire the scientific skills essential for a career working with mammals.
Mammals, Amphibians, and Reptiles of Costa Rica
by Carrol L. HendersonTo help visitors, as well as local residents, identify and enjoy the wildlife of Costa Rica, Carrol L. Henderson published Field Guide to the Wildlife of Costa Rica in 2002, and it instantly became the indispensable guide. Now Henderson has created a field guide dedicated to the monkeys, sloths, treefrogs, lizards, crocodiles, and other animals that travelers are most likely to see while exploring the wild lands of Costa Rica. He includes fascinating information on their natural history, ecology, identification, and behavior gleaned from his forty years of travels, studies, and wildlife viewing in Costa Rica, as well as details on where to see these remarkable and beautiful creatures. The mammals, amphibians, and reptiles are illustrated by stunning and colorful photographs-most of which were taken in the wild by Henderson. A detailed and invaluable appendix that identifies many of Costa Rica's best wildlife-watching destinations, lodges, and contact information for trip-planning purposes completes the volume.
Mammals from the Age of Dinosaurs: Origins, Evolution, and Structure
by Zofia Kielan-Jaworowska Richard Cifelli Zhe-Xi LuoThe fossil record on Mesozoic mammals has expanded by orders of magnitude over the past quarter century. New specimens, some of them breathtakingly complete, have been found in nearly all parts of the globe at a rapid pace. Coupled with the application of new scientific approaches and techniques, these exciting discoveries have led to profound changes in our interpretation of early mammal history. Mesozoic mammals have come into their own as a rich source of information for evolutionary biology. Their record of episodic, successive radiations speaks to the pace and mode of evolution. Early mammals were small, but they provide key information on the morphological transformations that led to modern mammals, including our own lineage of Placentalia. Significant and fast-evolving elements of the terrestrial biota for much of the Mesozoic, early mammals have played an increasingly important role in studies of paleoecology, faunal turnover, and historical biogeography. The record of early mammals occupies center stage for testing molecular evolutionary hypotheses on the timing and sequence of mammalian radiations. Organized according to phylogeny, this book covers all aspects of the anatomy, paleobiology, and systematics of all early mammalian groups, in addition to the extant mammalian lineages extending back into the Mesozoic.
Mammals of Colorado, Second Edition
by James P. Fitzgerald Carron A. Meaney David M. ArmstrongCo-published with the Denver Museum of Nature & Science. Thoroughly revised and updated, Mammals of Colorado, Second Edition is a comprehensive reference on the nine orders and 128 species of Colorado's recent native fauna, detailing each species' description, habitat, distribution, population ecology, diet and foraging, predators and parasites, behavior, reproduction and development, and population status. An introductory chapter on Colorado's environments, a discussion of the development of the fauna over geologic time, and a brief history of human knowledge of Coloradan mammals provide ecological and evolutionary context. The most recent records of the state's diverse species, rich illustrations (including detailed maps, skull drawings, and photographs), and an extensive bibliography make this book a must-have reference. Amateur and professional naturalists, students, vertebrate biologists, and ecologists as well as those involved in conservation and wildlife management in Colorado will find value in this comprehensive volume.
The Mammals of Luzon Island: Biogeography and Natural History of a Philippine Fauna
by Lawrence R. Heaney Danilo S. Balete Eric A. RickartA beautifully illustrated guide to the complete mammalian biodiversity of the Philippines’ largest island.Revealing the astounding mammalian diversity found on the largest Philippine island, The Mammals of Luzon Island is a unique book that functions both as a field guide and study of tropical fauna. The book features 120 fully illustrated species profiles and shows how the mammals fit into larger questions related to evolution, ecology, and biogeography. Luzon’s stunning variety of mammals includes giant fruit-eating bats; other bats so small that they can roost inside bamboo stems; giant plant-eating rodents that look like, but are not, squirrels; shrews that weigh less than half an ounce; the rapidly disappearing Philippine warty pig; and the long-tailed macaque, Luzon’s only nonhuman primate. While celebrating Luzon’s remarkably rich mammal fauna, the authors also suggest conservation strategies for the many species that are under threat from a variety of pressures. Based on a century of accumulated data and fifteen years of intensive study, The Mammals of Luzon Island delivers a message that will appeal equally to scientists, conservationists, and ecologically minded travelers.
Mammals of Mexico
by Gerardo CeballosThe most comprehensive reference on Mexico's diverse mammalian fauna.Mammals of Mexico is the first reference book in English on the more than 500 types of mammal species found in the diverse Mexican habitats, which range from the Sonoran Desert to the Chiapas cloud forests. The authoritative species accounts are written by a Who’s Who of experts compiled by famed mammalogist and conservationist Gerardo Ceballos.Ten years in the making, Mammals of Mexico covers everything from obscure rodents to whales, bats, primates, and wolves. It is thoroughly illustrated with color photographs and meticulous artistic renderings, as well as range maps for each species. Introductory chapters discuss biogeography, conservation, and evolution. The final section of the book illustrates the skulls, jaws, and tracks of Mexico’s mammals. This unparalleled collection of scientific information on, and photographs of, Mexican wildlife belongs on the shelf of every mammalogist, in public and academic libraries, and in the hands of anyone curious about Mexico and its wildlife.
Mammals of North America - Volume 1: Systematics and Taxonomy
by Sergio Ticul Álvarez-CastañedaThe book synthesizes nomenclature, systematics, and descriptions of North American mammal species. Clear, simple and illustrated identification keys are provided to make knowledge of mammals easier and facilitate the training both students and professionals in the field, including readers without extensive experience. Descriptions of the different species are provided up to Order, highlighting the diagnostic features that allow identifying them promptly while the reader learns how to make subsequent identifications without having the book at hand. Each species comes with potential distribution maps based on existing records in the main museums of North America. The book includes the description, characteristics and distribution maps of the 781 species with range in the North America subcontinent
Mammals of North America - Volume 2: Systematics and Taxonomy
by Sergio Ticul Álvarez-CastañedaThe second volume of this book series synthesizes nomenclature, systematics, and descriptions of North American mammal species. Clear, simple and illustrated identification keys are provided to make knowledge of mammals easier and facilitate the training both students and professionals in the field, including readers without extensive experience. Descriptions of the different species are provided up to Order, highlighting the diagnostic features that allow identifying them promptly while the reader learns how to make subsequent identifications without having the book at hand. Each species comes with potential distribution maps based on existing records in the main museums of North America. The book includes the description, characteristics and distribution maps of the 781 species with range in the North America subcontinent
The Mammals Of Texas
by David J. Schmidly Robert D. Bradley“[This book] easily fills the role of both a field guide and a desk reference, and is written in a style that appeals to the professional biologist and amateur naturalist alike. . . . [It] should prove useful to anyone with an interest in the mammal fauna of Texas or the southern Great Plains.” —Prairie Naturalist <p><p> The Mammals of Texas has been the standard reference since the first edition was coauthored by William B. Davis and Walter P. Taylor in 1947. Revised several times over the succeeding decades, it remains the most authoritative source of information on the mammalian wildlife of Texas, with physical descriptions and life histories for 202 species, abundant photographs and drawings, and distribution maps. <p><p> In this new edition, David J. Schmidly is joined by one of the most active researchers on Texas mammals, Robert D. Bradley, to provide a thorough update of the taxonomy, distribution, and natural history of all species of wild mammals that inhabit Texas today. Using the most recent advances in molecular biology and in wildlife ecology and management, the authors include the most current information about the scientific nomenclature, taxonomy, and identification of species, while also covering significant advances in natural history and conservation.