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Mass Spectrometry of Peptides
by Dominic M. DesiderioThe purpose of this book is to collect into one volume the research done on the mass spectrometry of peptides. It balances a range of topics including theory, instrumentation, analytical techniques, and biological applications. The scope of the work contains three major sections: ionization methods, instrumental developments, and analysis of peptides. It describes 252Cf plasma desorption and laser-induced multiphoton ionization methodology. This exciting resource covers many new areas, including continuous flow FAB, quantification of human neuropeptides, and peptide mapping. It also discusses Q-FTMS, cross-links, and metal ions.
Mass Spectrometry of Polymers
by Giorgio Montaudo Robert P. LattimerMass Spectrometry (MS) has rapidly become an indispensable tool in polymer analysis, and modern MS today complements in many ways the structural data provided by Nuclear Magnetic Resonance (NMR) and Infrared (IR) methods. Recent advances have sparked a growing interest in this field and established a need for a summary of progress made and results
Mass Spectrometry of Polymers – New Techniques
by Minna HakkarainenEmerging Mass Spectrometric Tools for Analysis of Polymers and Polymer Additives, by Nina Aminlashgari and Minna Hakkarainen. Analysis of Polymer Additives and Impurities by Liquid Chromatography/Mass Spectrometry and Capillary Electrophoresis/Mass Spectrometry, by Wolfgang Buchberger and Martin Stiftinger. Direct Insertion Probe Mass Spectrometry of Polymers, by Jale Hacaloglu Mass Spectrometric Characterization of Oligo- and Polysaccharides and Their Derivatives, by Petra Mischnick. Electrospray Ionization-Mass Spectrometry for Molecular Level Understanding of Polymer Degradation, by Minna Hakkarainen.
Mass Spectrometry of Proteins and Peptides
by John R. ChapmanJohn R. Chapman recreates the success of his earlier acclaimed book (Protein and Peptide Analysis by Mass Spectrometry, 1996) with a major new collection of cutting-edge methods in the analysis of proteins and peptides. Contributed by well-established investigators, each chapter provides background information before guiding the researcher step-by-step through the experimental process, with detailed instructions to help assure experimental success. The applications covered range widely and include protein sequencing, higher-order structure determination, epitope mapping, kinetics, quantitation, glycosylation analysis, and bacterial typing. Authoritative and eminently practical, Mass Spectrometry of Proteins and Peptides demonstrates the full scope of this versatile analytical technique. All protein chemists and biochemists, as well as bioanalytical scientists, who want to exploit these powerful methods in their work, will find this book indispensable.
Mass Spectrometry of Proteins and Peptides
by Ljiljana Paša-Tolic Mary S. LiptonWhen the last edition of this book was published in 2000, the field of proteomics was in its infancy. Now in its adolescence, proteomics is fundamentally transforming biological and medical research. Much of this transformation can be attributed to technological advancements, particularly in mass spectrometry. As a result of these rapid developments that have led to expanded areas of research and innovative applications, an update to Mass Spectrometry of Proteins and Peptides is not only worthwhile, but arguably mandatory. Spanning fields from microbial forensics and clinical applications to protein structure, dynamics and function, the following chapters written by leading experts serve as a forum for presenting some of the latest revolutionizing methods for mass spectrometry-based characterization of proteins and peptides. Staying faithful to the spirit of the Methods in Molecular BiologyTM series, all chapters are written in the same format, whereby each chapter opens with a basic description of the method, followed by a description of the protocol and then practical step-by-step instructions to ensure experimental success. Mass Spectrometry of Proteins and Peptides: Methods and Protocols, Second Edition is a valuable resource for novice and seasoned practitioners in the fields of biochemistry, molecular biology, clinical chemistry, immunology, genetic, microbiology and toxicology.
Mass Spectrometry–Based Glycoproteomics and Its Clinic Application
by Haojie LuAs one of the most extensive and important protein post-translational modifications, glycosylation plays a vital role in regulating organisms and is associated with various physiological and pathological processes. Recently, researchers have focused on the need to characterize protein glycosylation sites, structures, and their degree of modification, to better understand their biological functions while also looking for potential biomarkers for diagnosis and treatment of disease. Mass spectrometry (MS) is one of the most powerful tools used to study biomolecules including glycoproteins and glycans. With the continuous development of glycoproteomics and glycomics based on MS analysis, more techniques have evolved and contribute to understanding the structure and function of glycoproteins and glycans. This book reviews advancements achieved in MS-based glycoproteomic analysis, including a wide range of analytical methodologies and strategies involved in selective enrichment; as well as qualitative, quantitative, and data analysis, together with their clinical applications. Significant examples are discussed to illustrate the principles, laboratory protocols, and advice for key implementation to ensure successful results. Mass Spectrometry–Based Glycoproteomics and Its Clinic Application will serve as a valuable resource to elucidate new techniques and their applications for students, postdocs, and researchers working in proteomics, glycoscience, analytical chemistry, biochemistry, and clinical medicine. Editor: Haojie Lu is a professor at Fudan University, specializing in proteomics based on mass spectrometry with particular emphasis on novel technologies for separation and identification of low-abundant proteins and post-translationally modified proteins (including glycosylation), as well as relative and absolute quantification methods for proteomics.
Mass Term Effect on Fractional Quantum Hall States of Dirac Particles (Springer Theses)
by Kouki YonagaThis book presents the high-precision analysis of ground states and low-energy excitations in fractional quantum Hall states formed by Dirac electrons, which have attracted a great deal of attention. In particular the author focuses on the physics of fractional quantum Hall states in graphene on a hexagonal boron nitride substrate, which was recently implemented in experiments. The numerical approach employed in the book, which uses an exact numerical diagonalization of an effective model Hamiltonian on a Haldane’s sphere based on pseudopotential representation of electron interaction, provides a better understanding of the recent experiments. The book reviews various aspects of quantum Hall effect: a brief history, recent experiments with graphene, and fundamental theories on integer and fractional Hall effects. It allows readers to quickly grasp the physics of quantum Hall states of Dirac fermions, and to catch up on latest research on the quantum Hall effect in graphene.
Mass Transfer and Separation Processes: Principles and Applications, Second Edition
by Diran BasmadjianMass transfer along with separation processes is an area that is often quite challenging to master, as most volumes currently available complicate the learning by teaching mass transfer linked with heat transfer, rather than focusing on more relevant techniques. With this thoroughly updated second edition, Mass Transfer and Separation Processes: Pr
Mass Transfer Driven Evaporation From Capillary Porous Media (Advances in Drying Science and Technology)
by Rui WuMass Transfer–Driven Evaporation from Capillary Porous Media offers a comprehensive review of mass transfer–driven drying processes in capillary porous media, including pore-scale and macro-scale experiments and models. It covers kinetics of drying of a single pore, pore-scale experiments and models, macro-scale experiments and models, and understanding of the continuum model from pore-scale studies. The book: Explains the detailed transport processes in porous media during drying. Introduces cutting-edge visualization experiments of drying in porous media. Describes the pore network models of drying in porous media. Discusses the continuum models of drying in porous media based on pore-scale studies. Points out future research opportunities. Aimed at researchers, students and practicing engineers, this work provides vital fundamental and applied information to those working in drying technology, food processes, applied energy, and mechanical and chemical engineering.
Mass Transfer Dynamics of Contaminants in Fractured Media
by Zhi Dou Zhifang Zhou Jinguo Wang Yong HuangThis book focuses on many aspects of mass transfer dynamics of contamination in fractured media. First, it discusses the concept, structure and properties of fractured media. It then traces topics such as basic law of seepage in fractured media, the basic mass transfer theory of fractured media, numerical simulation of mass transfer process in fractured media, mathematical model and parameter inversion of mass transfer in fractured media and the frontier of mass transfer in fractured media. The book is a comprehensive reference for both graduate students and scientific and technological teams working in the fields of hydrogeology, water conservation, mining and civil engineering, environmental engineering, transportation, civil air defense and national defense.
Mass Transfer Models in Membrane Processes: Applications in Artificial Organs (SpringerBriefs in Bioengineering)
by Manfred RaffThis book serves as an introduction on mass transfer models in membrane processes, with a special focus on their applications in Artificial Organs. Various such models are discussed while multiple easy to use module equations are presented, enabling readers to gain basic knowledge of the mass flow of toxins across membranes. This is particularly interesting to membrane manufacturers who may use these equations to improve the relation of module performances and production costs. Additionally, examples which specialize on artificial organs, but in principle can be applied to analogous environmental, food and biotechnology processes- are analysed. This book will appeal to readers who want to understand how membrane modules and processes can be optimized and will be a great tool for graduates, researchers and professionals working in this field.
Mass Transfer Operations for the Practicing Engineer
by Francesco Ricci Louis TheodorePart of the Essential Engineering Calculations Series, this book presents step-by-step solutions of the basic principles of mass transfer operations, including sample problems and solutions and their applications, such as distillation, absorption, and stripping. Presenting the subject from a strictly pragmatic point of view, providing both the principles of mass transfer operations and their applications, with clear instructions on how to carry out the basic calculations needed, the book also covers topics useful for readers taking their professional exams.
Mass Transfers and Physical Data Estimation
by Abdelhanine BenallouMany practical operations, such as environment depollution, blood dialysis or product purification, require matter transfer. With an emphasis on the aforementioned subjects, this book revisits the founding principles of materials transfer on the basis of Fick’s first law, which constitutes the foundation of diffusional phenomena. Additionally, continuity equations translating the macroscopic balances of systems are established. These balances constitute Fick’s second law, which can be applied to quantify the fluxes of matter transferred in each situation, provided physical data is available. To this end, Mass Transfers and Physical Data Estimation pays particular attention to methods of data estimation. Methods presented in this book are applied to several practical cases, such as diffusion in catalytic reactions or the reconstitution of cartilage in human bone joints.
Mass Transport in Solids and Fluids
by David S. WilkinsonThe field of matter transport is central to understanding the processing of materials and their subsequent mechanical properties. This text gives a solid grounding in the principles of matter transport and their application to a range of engineering problems. The author develops a unified treatment of mass transport applicable to both solids and liquids. Traditionally, matter transport in fluids is considered as an extension of heat transfer and can appear to have little relationship to diffusion in solids. This unified approach clearly makes the connection between these important fields. Aimed at advanced undergraduate and beginning graduate students of materials science and engineering and related disciplines, the book contains numerous worked examples and unsolved problems.
The Massachusetts General Hospital Clinical Approach to Vascular Ultrasound: Protocols and Procedures
by Anahita Dua Drena Root Scott Manchester Young KimThis book is designed to provide easy to reference, up to date protocols and procedures for vascular ultrasound. The text also delineates how to interpret imaging findings and implement results for optimal patient care outcomes. Chapters thoroughly cover an array of topics focused on the interpretation of vascular ultrasound, including transcranial Doppler, hemodialysis fistula mapping, and pelvic venous duplex, as well as the protocols and standards of the Massachusetts General Hospital Vascular Lab. Expert authors provide step by step detail on how to perform vascular lab examinations correctly, how to clinically interpret results, and how to implement findings into clinical practice. There is additionally coverage of how to develop and receive accreditation for a new vascular laboratory. This is an ideal guide for vascular surgeons, general surgeons, primary care physicians, vascular technologists, interventional radiologists, cardiologists, vascular medicine specialists, anesthesiologist and any practitioners who practice vascular ultrasound.
Massacre of the Miners
by T. Neill AndersonThe fourth book in the Horrors of History historical fiction series follows several characters in Colorado in 1914, just before and during the Ludlow Massacre, which was an attack by the Colorado National Guard and Colorado Fuel and Iron Company camp guards on a tent colony of 1,200 striking coal miners and their families.
Massage Mastery: From Student To Professional
by Anne WilliamsThis comprehensive introductory massage text is organized into 24 chapters that cover the key areas addressed in massage programs of 500 to 1200 hours in length. Topics inside the chapters are structured to allow for manageable reading assignments that build a student's sense of accomplishment and motivation. Written and designed for today's adult learner, the book offers a broad discussion of foundation massage with appropriate depth for a beginning student progressing to an entry-level professional. It also contains new topics that are necessary to prepare today's adult learners for successful massage careers. (Note: It does not cover anatomy and physiology, as A&P is best thoroughly covered in a separate textbook. ) A helpful appendix on health care terminology, a comprehensive massage glossary, and a robust set of ancillary materials complete the package. The companion Study Guide contains topic-specific Rubrics, Learning Contracts, and a variety of exercises and activities for students.
Massenspektrometrie: Eine Einführung
by Herbert Budzikiewicz Mathias SchäferDie Massenspektrometrie, besonders in Kombination mit anderen Verfahren hat sich mittlerweile zu einer der wichtigsten Analysemethoden entwickelt, und zwar nicht nur in der Chemie, sondern auch in Nachbardisziplinen wie der Umweltanalytik, den Polymerwissenschaften, oder der Medizin. Die Neuaufl age dieser bewahrten Einfuhrung vermittelt den Nutzern die Grundlagen der Massenspektrometrie, tragt aber auch den rasanten Weiterentwicklungen der letzten Jahre Rechnung. Neben apparativen Neuentwicklungen auf dem Gebiet der Analysatoren sowie bei neuen Ionisationsmethoden werden auch inzwischen etablierte Methoden und neue Anwendungsfelder - Umwelt-, Doping-, Lebensmittel-, Proteomics- Analytik - anhand von ausgearbeiteten Beispielen erlautert. Master-Studenten aller chemie-nahen Studiengange werden mit klarer Didaktik Grundlagen, aktuelle Techniken sowie neue Entwicklungen in der Massenspektrometrie vermittelt.
Massive
by Ian SampleA prize-winning science writerOCOs history of the forty-year search for the Higgs boson, and the intense rivalries, clashing egos, and grand ambition that led to a world-changing discovery
Massive: The Missing Particle That Sparked the Greatest Hunt in Science
by Ian SampleThe biggest science story of our time, Massive spans four decades, weaving together the personal narratives and international rivalries behind the search for the #147;God" particle, or Higgs boson. A story of grand ambition, intense competition, clashing egos, and occasionally spectacular failures, Massive is the first book that reveals the science, culture, and politics behind the biggest unanswered question in modern physics#151;what gives things mass? Drawing upon his unprecedented access to Peter Higgs, after whom the particle is named, award-winning science writer Ian Sample chronicles the multinational and multibillion-dollar quest to solve the mystery of mass. For scientists, to find the God particle is to finally understand the origin of mass, and until now, the story of their search has never been told.
Massive
by Ian SampleThe biggest science story of our time, Massive spans four decades, weaving together the personal narratives and international rivalries behind the search for the "God" particle, or Higgs boson. A story of grand ambition, intense competition, clashing egos, and occasionally spectacular failures, Massive is the first book that reveals the science, culture, and politics behind the biggest unanswered question in modern physics-what gives things mass? Drawing upon his unprecedented access to Peter Higgs, after whom the particle is named, award-winning science writer Ian Sample chronicles the multinational and multibillion-dollar quest to solve the mystery of mass. For scientists, to find the God particle is to finally understand the origin of mass, and until now, the story of their search has never been told.
The Mast Cell: A Multifunctional Effector Cell
by Domenico RibattiMast cells (MC) are phylogenetically old cells which are distributed throughout the human organism. MC are found in almost all of the major organs and tissues of the body, particularly in association with connective tissue structures such as blood vessels, lymphatic vessels and nerves, and in proximity to surfaces that interface the external environment, such as those of the respiratory and gastrointestinal system and the skin. This selective accumulation at tissue sites where foreign material attempts to invade the host suggests that MC are among the first cells to initiate defensive mechanisms. MC have long been recognized as key cells of type I hypersensitivity reactions. Several lines of evidence, however, indicate that they not only express critical effector functions in classic IgE-associated allergic disorders, but also play important roles in host defense against parasites, bacteria and perhaps even viruses. Indeed, it is now clear that MC can contribute to host defense in the context of either acquired or innate immune responses through the release of a myriad of pro-inflammatory and immunoregulatory molecules and the expression of a wide spectrum of surface receptors for cytokines and chemokines. Moreover, there is growing evidence that MC exert distinct non-immunological functions, playing a relevant role in tissue homeostasis, remodeling and fibrosis as well as in the processes of tissue angiogenesis.
Mast Cells and Tumours
by Enrico Crivellato Domenico RibattiMast cells are versatile, tissue-homing secretory cells, which were first described by Paul Ehrlich in 1878. Mast cells have long been implicated in the pathogenesis of allergic reactions and certain protective responses to parasites. Their functional role, however, has been discovered to be increasingly complex and multifarious. Mast cells have been implicated in various cell-mediated immune reactions, being found in tissues from multiple disease sites, and as a component of the host reaction to bacteria, parasite, and even virus infections. They have also been shown to participate to angiogenic and tissue repair processes after injury. The importance of a possible functional link between chronic inflammation and cancer has long been recognized. As most tumours contain inflammatory cell infiltrates, which often include plentiful mast cells, the question as to the possible contribution of mast cells to tumour development has progressively been emerged. In this book, the general biology of these cells, their development, anatomical distribution and phenotype as well as their secretory products will first be discussed. The biology of tumour cells, their structural and molecular characteristics, the specificity of the tumour microenvironment and the development of a vascular network in the tumour context will be analyzed. The involvement of mast cells in tumour biology and tumour fate will then be considered, with particular emphasis on the capacity of these cells to stimulate tumour growth by promoting angiogenesis and lymphangiogenesis. The last chapter suggest that mast cells may serve as a novel therapeutic target for cancer treatment.
The Master Algorithm: How the Quest for the Ultimate Learning Machine Will Remake Our World
by Pedro DomingosAlgorithms increasingly run our lives. They find books, movies, jobs, and dates for us, manage our investments, and discover new drugs. More and more, these algorithms work by learning from the trails of data we leave in our newly digital world. Like curious children, they observe us, imitate, and experiment. And in the world’s top research labs and universities, the race is on to invent the ultimate learning algorithm: one capable of discovering any knowledge from data, and doing anything we want, before we even ask. Machine learning is the automation of discovery--the scientific method on steroids--that enables intelligent robots and computers to program themselves. No field of science today is more important yet more shrouded in mystery. Pedro Domingos, one of the field’s leading lights, lifts the veil for the first time to give us a peek inside the learning machines that power Google, Amazon, and your smartphone. He charts a course through machine learning’s five major schools of thought, showing how they turn ideas from neuroscience, evolution, psychology, physics, and statistics into algorithms ready to serve you. Step by step, he assembles a blueprint for the future universal learner--the Master Algorithm--and discusses what it means for you, and for the future of business, science, and society. If data-ism is today’s rising philosophy, this book will be its bible. The quest for universal learning is one of the most significant, fascinating, and revolutionary intellectual developments of all time. A groundbreaking book, The Master Algorithm is the essential guide for anyone and everyone wanting to understand not just how the revolution will happen, but how to be at its forefront.
The Master and His Emissary: The Divided Brain and the Making of the Western World
by Iain McGilchristA new edition of the bestselling classic – published with a special introduction to mark its 10th anniversary This pioneering account sets out to understand the structure of the human brain – the place where mind meets matter. Until recently, the left hemisphere of our brain has been seen as the ‘rational’ side, the superior partner to the right. But is this distinction true? Drawing on a vast body of experimental research, Iain McGilchrist argues while our left brain makes for a wonderful servant, it is a very poor master. As he shows, it is the right side which is the more reliable and insightful. Without it, our world would be mechanistic – stripped of depth, colour and value.