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Molecular Biology of Long Non-coding RNAs
by Ahmad M. KhalilThis second edition shows how long non-coding RNAs (lnc)RNAs have emerged as a new paradigm in epigenetic regulation of the genome. Thousands of lncRNAs have been identified and observed in a wide range of organisms. Unlike mRNA, lncRNA have no protein-coding capacity. So, while their function is not entirely clear, they may serve as key organizers of protein complexes that allow for higher order regulatory events. Advances in the field also include better characterization of human long non-coding RNAs, novel insights into their roles in human development and disease, their diverse mechanisms of action and novel technologies to study them.
Molecular Biology of Valvular Heart Disease
by Nalini M. RajamannanThe cellular mechanisms of valvular heart disease have not been elucidated until the last decade. To date, there is no medical therapy that is FDA or CE mark approved for the treatment and/or slowing the progression of this disease. This textbook will provide the cellular basis for medical therapy. Over the past decade, research laboratories are more and more evolving into valvular biology programs from the traditional vascular biology. The science between the two disciplines, although has several similarities has unique cellular targets secondary to the embryologic derivation of the heart valve and the hemodynamics involved in the understanding of this disorders. This textbook will be a natural progression from the recently published text Cardiac Valvular Medicine, Springer 2012. This new textbook will provide the cellular details and the more basic molecular biology approaches towards understanding the disease, providing novel cellular targets and finally developing future clinical trials in the medical treatment of valvular heart disease in the future.
Molecular Biology of Weed Control
by Jonathan GresselMolecular Biology of Weed Control assesses the impact of the new tools of molecular biology on the science of weed control as well as the ways in which the science of weed control has helped and influenced molecular biology. Accentuating the utility of molecular biology to contribute to the control of intransigent weed species both in the developing and developed world, the book also looks to the future and describes how molecular biology can be used to diminish the use of chemical herbicides, and enhance crop competitiveness for light, nutrients and water. This volume is essential reading for all weed scientists, environmental students, researchers, and regulators.
Molecular Biology of the Biological Control of Pests and Diseases of Plants
by Muthukumaran Gunasekaran Darrell Jack WeberWhile many books are available on biological control, this is the only book to detail the application of molecular biology to control of pests and diseases. Each chapter deals with a different pathogen and the application of new molecular biological techniques to the biocontrol of the pathogen.This new reference presents the most comprehensive list of organisms available. Internationally respected experts discuss viruses, bacteria, fungi, nematodes, protozoa, weeds, and insects. Types of control methods are described, and techniques commonly used in molecular biology to identify the etiological agents, diagnose diseases, and develop control methods are reviewed.
Molecular Biology of the Cell
by Keith Roberts Hunt Alexander Johnson Julian Lewis Martin Raff Peter WalterFor nearly a quarter century Molecular Biology of the Cell has been the leading cell biology textbook. This tradition continues with the new Fifth Edition, which has been completely revised and updated to describe our current, rapidly advancing understanding of cell biology. To list but a few examples, a large amount of new material is presented on epigenetics; stem cells; RNAi; comparative genomics; the latest cancer therapies; apoptosis (now its own separate chapter); and cell cycle control and the mechanics of M phase (now integrated into one chapter). The hallmark features of Molecular Biology of the Cell have been retained, such as its consistent and comprehensive art program, clear concept headings, and succinct section summaries. Additionally, in response to extensive feedback from readers, the Fifth Edition now includes several new features. It is now more portable. Chapters 1-20 are printed and Chapters 21-25, covering multicellular systems, are provided as PDF files on the free Media DVD-ROM which accompanies the book. * And for the first time, Molecular Biology of the Cell now contains end-of-chapter questions. These problems, written by John Wilson and Tim Hunt, emphasize a quantitative approach and the art of reasoning from experiments, and they will help students review and extend their knowledge derived from reading the textbook. The Media DVD-ROM, which is packaged with every copy of the book, contains PowerPoint(r) presentations with all of the figures, tables and micrographs from the text (available as JPEGs too). Also included is the Media Player, which plays over 125 movies animations, videos, and molecular models all with voice-over narration. A new reader-friendly feature is the integration of media codes throughout the text that link directly to relevant videos and animations. The Media DVD-ROM holds the multicellular systems chapters (21-25) of the text as well. By skillfully extracting the fundamental concepts from this enormous and ever-growing field, the authors tell the story of cell biology, and thereby create a coherent framework through which readers may approach and enjoy this subject that is so central to all of biology. * There is also a reference edition of Molecular Biology of the Cell, Fifth Edition (ISBN 978-0-8153-4111-6) that contains Chapters 1-25 entirely in printed format.
Molecular Biology of the Cell (Seventh Edition)
by David Morgan Bruce Alberts Rebecca Heald Alexander Johnson Martin Raff Keith Roberts Peter WalterThe definitive text in cell biology now with the Digital Problems Book in Smartwork For more than four decades, Molecular Biology of the Cell has distilled the vast amount of scientific knowledge to illuminate basic principles, enduring concepts, and cutting-edge research. The Seventh Edition has been extensively revised and updated with the latest research, and has been thoroughly vetted by experts and instructors. The classic companion text, The Problems Book, has been reimagined as the Digital Problems Book in Smartwork, an interactive digital assessment course with a wide selection of questions and automatic-grading functionality. The digital format with embedded animations and dynamic question types makes the Digital Problems Book in Smartwork easier to assign than ever before—for both in-person and online classes. This purchase offers access to the digital ebook only.
Molecular Biology of the Cell (Sixth Edition): Overhead Transparencies
by Keith Roberts David Morgan Julian Lewis Martin Raff Peter Walter Bruce Alberts Alexander D. JohnsonThe definitive text in cell biology As the amount of information in biology expands dramatically, it becomes increasingly important for textbooks to distill this vast amount of scientific knowledge into concise principles and enduring concepts. Molecular Biology of the Cell, Sixth Edition accomplishes this goal with clear writing and beautiful illustrations. The Sixth Edition has been extensively revised and updated with the latest research in cell biology, and it provides an exceptional framework for teaching and learning.
Molecular Biology of the Cell, Sixth Edition
by Keith Roberts David Morgan Alexander Johnson Julian Lewis Martin Raff Peter Walter Bruce AlbertsAs with previous editions, Molecular Biology of the Cell, Sixth Edition accomplishes this goal with clear writing and beautiful illustrations. The Sixth Edition has been extensively revised and updated with the latest research in the field of cell biology, and it provides an exceptional framework for teaching and learning.
Molecular Biology of the Cell: The Problems Book
by Bruce AlbertsAs the amount of information in biology expands dramatically, it becomes increasingly important for textbooks to distill the vast amount of scientific knowledge into concise principles and enduring concepts.As with previous editions, Molecular Biology of the Cell, Sixth Edition accomplishes this goal with clear writing and beautiful illustrations. The Sixth Edition has been extensively revised and updated with the latest research in the field of cell biology, and it provides an exceptional framework for teaching and learning. The entire illustration program has been greatly enhanced.Protein structures better illustrate structure–function relationships, icons are simpler and more consistent within and between chapters, and micrographs have been refreshed and updated with newer, clearer, or better images. As a new feature, each chapter now contains intriguing openended questions highlighting “What We Don’t Know,” introducing students to challenging areas of future research. Updated end-of-chapter problems reflect new research discussed in the text, and these problems have been expanded to all chapters by adding questions on developmental biology, tissues and stem cells, pathogens, and the immune system.
Molecular Biology of the Hepatitis B Virus
by Alan McLachlanMolecular Biology of the Hepatitis B Virus presents a comprehensive account of the various molecular aspects of the life cycle of the hepatitis B virus (HBV). Topics covered include the animal model systems, sequence data on the hepadnavirus genomes, the transcripts coded for the biral genome and sequence elements involved in regulating their expression, hepadnavirus replication, and analysis of the various HBV gene products and their role in virion synthesis and assembly. Other important features of the book include its discussions of the consequences of long term exposure to hepadnavirus infection and its association with hepatocellular carcinoma, the use of recombinant technologies in the generation of second generation vaccines, and the utilization of recombinant technologies to analyze an immune mediated disease. Researchers studying hepadnaviruses will find a wealth of information in this essential reference volume.
Molecular Biology of the SARS-Coronavirus
by Sunil K. LalThe SARS outbreak in 2002 caused unprecedented devastation and exhibited unusually high rates of morbidity and mortality. For the SARS coronavirus, the transmission vehicle was man. What added to the spread was man's convenient, rapid and affordable ways of travel that caused the virus to spread globally in a short span of time. The SARS coronavirus jumped the species barrier, similar to many recent zoonotic diseases - avian flu, swine flu, Nipah and encephalitis virus. It is extremely important for us to understand the enemy before it strikes again in order to be able to combat such outbreaks as and when they occur. Molecular mechanisms that the virus exploits within its host and that result in infection and pathogenesis are the key to being able to block its transmission cycle. In this book, leading scientists from around the globe have discussed molecular aspects of viral entry, replication, viral gene expression, pathogenesis and host immune response against the SARS coronavirus.
Molecular Biology: Structure and Dynamics of Genomes and Proteomes
by Jordanka ZlatanovaMolecular Biology: Structure and Dynamics of Genomes and Proteomes second edition illustrates the essential principles behind the transmission and expression of genetic information at the level of DNA, RNA, and proteins. Emphasis is on the experimental basis of discovery and the most recent advances in the field while presenting a rigorous, yet still concise, summary of the structural mechanisms of molecular biology. Topics new to this edition include the CRISPR-Cas gene editing system, Coronaviruses – structure, genome, vaccine and drug development, and newly recognized mechanisms for transcription termination. The text is written for advanced undergraduate or graduate-level courses in molecular biology. Key Features · Highlights the experimental basis of important discoveries in molecular biology. · Thoroughly updated with new information on gene editing tools, viruses, and transcription mechanisms, termination and antisense. · Provides learning objectives for each chapter. · Includes a list of relevant videos from the Internet about the topics covered in the chapter.
Molecular Biomarkers for Cancer Diagnosis and Therapy
by Ranbir Chander Sobti Aastha Sobti Haruhiko SugimuraThis book presents recent advancements, challenges, and clinical implications of molecular biomarkers in various cancers. This book highlights the clinical applications of biomarkers are extensive for cancer risk assessment, screening and early detection of cancer, accurate diagnosis, patient prognosis, prediction of response to therapy, and cancer surveillance and monitoring response. It also explores the progress of predictive biomarkers as an adjunctive tool to tumor immunotherapy in effectively identifying the efficacy of immune checkpoint inhibitors and discusses their future directions in achieving precision immuno-oncology. Further, the book examines the combination of next-generation sequencing and advanced computational data analysis approaches in the understanding of the genomic underpinnings of cancer development and progression. Towards the end, the chapter discusses the role of some commonly investigated phytochemicals and their epigenetic targets that are of particularinterest in cancer prevention and cancer therapy. It is a must for researchers as well as advanced students and physicians in the field of cancer and clinical oncologists.
Molecular Biomethods Handbook
by Ralph Rapley John M. WalkerAn authoritative team of investigators illuminate the core bioanalytical techniques used every day in their own laboratories, and laboratories throughout the world. These highly experienced scientists fully explain both the theory behind, and the application of, these key techniques, and include extensive references for those seeking detailed laboratory protocols. The techniques covered range from the extraction, separation, detection, and characterization of nucleic acids to gene cloning and library production, mapping, expression, transgenesis, differential display, and DNA profiling, to name a few. Numerous key protein methods, as well as support and related techniques, are also included. The goal is to provide established scientists and novices who are new to these techniques with a deeper understanding of the widest variety of biotechniques and their applications.
Molecular Biomethods Handbook
by Ralph Rapley John M. WalkerAn authoritative team of investigators illuminate the core bioanalytical techniques used every day in their own laboratories, and laboratories throughout the world. These highly experienced scientists fully explain both the theory behind, and the application of, these key techniques, and include extensive references for those seeking detailed laboratory protocols. The techniques covered range from the extraction, separation, detection, and characterization of nucleic acids to gene cloning and library production, mapping, expression, transgenesis, differential display, and DNA profiling, to name a few. Numerous key protein methods, as well as support and related techniques, are also included. The goal is to provide established scientists and novices who are new to these techniques with a deeper understanding of the widest variety of biotechniques and their applications.
Molecular Biomineralization
by Werner E. MüllerThe concept of 'biomineralization' signifies mineralization processes that take place in close association with organic molecules or matrices. The awareness that mineral formation can be guided by organic molecules notably contributed to the understanding of the formation of the inorganic skeletons of living organisms. Modern electron microscopic and spectroscopic analyses have successfully demonstrated the participation of biological systems in several mineralization processes, and prominent examples include the formation of bio-silica in diatoms and sponges. This insight has already made the application of recombinant technology for the production of valuable inorganic polymers, such as bio-silica, possible. This polymer can be formed by silicatein under conditions that cannot be matched by chemical means. Similarly, the efforts described in this book have elucidated that certain organisms, bacteria in deep-sea polymetallic nodules and coccoliths in seamount crusts, are involved in the deposition of marine minerals. Strategies have already been developed to utilize such microorganisms for the biosynthesis and bioleaching of marine deposits. Moreover, studies reveal that bio-polymers enhance the hydroxyapatite formation of bone-forming cells and alter the expression of important regulators of bone resorption, suggesting a potential for bone regeneration and treatment / prevention of osteoporosis.
Molecular Biophysics for the Life Sciences
by Linda O. Narhi Norma Allewell Ivan RaymentThis volume provides an overview of the development and scope of molecular biophysics and in-depth discussions of the major experimental methods that enable biological macromolecules to be studied at atomic resolution It also reviews the physical chemical concepts that are needed to interpret the experimental results and to understand how the structure, dynamics, and physical properties of biological macromolecules enable them to perform their biological functions Reviews of research on three disparate biomolecular machines--DNA helicases, ATP synthases, and myosin--illustrate how the combination of theory and experiment leads to new insights and new questions
Molecular Biotechnology for Plant Food Production
by Octavio Paredes-LopezThe first single volume reference on the use of genetic engineering and molecular biology for plant food production, this book provides basic to in-depth approaches at the molecular level combining agricultural technology with food science and technology. It focuses on biotechnology 's role in the manipulation of cell and plant growth for enhanced
Molecular Biotechnology: Principles and Applications of Recombinant DNA (ASM Books #34)
by Bernard Glick Cheryl PattenSince 1994, Molecular Biotechnology: Principles and Applications of Recombinant DNA has introduced students to the fast-changing world of molecular biotechnology. With each revision, the authors have extensively updated the book to keep pace with the many new techniques in gene isolation and amplification, nucleic acid synthesis and sequencing, gene editing, and their applications to biotechnology. In this edition, authors Bernard R. Glick and Cheryl L. Patten have continued that tradition, but have also overhauled the book's organization to Detail fundamental molecular biology methods and recombinant protein engineering techniques, which provides students with a solid scientific basis for the rest of the book. Present the processes of molecular biotechnology and its successes in medicine, bioremediation, raw material production, biofuels, and agriculture. Examine the intersection of molecular biotechnology and society, including regulation, patents, and controversies around genetically modified products. Filled with engaging figures that strongly support the explanations in the text, Molecular Biotechnology: Principles and Applications of Recombinant DNA presents difficult scientific concepts and technically challenging methods in clear, crisp prose. This excellent textbook is ideal for undergraduate and graduate courses in introductory biotechnology, as well as, courses dedicated to medical, agricultural, environmental, and industrial biotechnology applications.
Molecular Biotechnology: Principles and Applications of Recombinant DNA (ASM Books)
by Bernard R. Glick Cheryl L. PattenMolecular Biotechnology Molecular Biotechnology Principles and Applications of Recombinant DNA SIXTH EDITION An authoritative introduction to the fast-changing world of molecular biotechnology In continuous publication since 1994 and now in its sixth edition, Molecular Biotechnology: Principles and Applications of Recombinant DNA has been effective in introducing this complex field to students for more than 25 years. This textbook covers essentially every aspect of the field of molecular biotechnology, which is constantly changing and adapting in light of new advances. This edition includes the latest techniques in DNA sequencing and genetic engineering of microbial, plant, and animal genomes, including human genome editing, as well as updates across many areas, such as: Immunological assays for disease diagnosis, more effective bacteriophage therapy, and new ways of dealing with antibiotic-resistant bacteria New and developing vaccines for influenza, tuberculosis, and emerging viral threats, including Zika and SARS-CoV-2 Engineering bacteria to perform plastic degradation and green algae to produce hydrogen, altering amino acid biosynthesis, and creating designer cellulosomes Production of humanized monoclonal antibodies in plants, modifying hybrid plants to produce clonal hybrids, and protecting plants from viral and fungal diseases Molecular Biotechnology features nearly 600 detailed figures and is an ideal textbook for undergraduate and graduate courses in introductory biotechnology, as well as courses dedicated to utilizing this technology, such as medical, agricultural, environmental, and industrial biotechnology applications.
Molecular Breeding for Rice Abiotic Stress Tolerance and Nutritional Quality
by Mohammad A HossainPresents the latest knowledge of improving the stress tolerance, yield, and quality of rice crops One of the most important cereal crops, rice provides food to more than half of the world population. Various abiotic stresses—currently impacting an estimated 60% of crop yields—are projected to increase in severity and frequency due to climate change. In light of the threat of global food grain insecurity, interest in molecular rice breeding has intensified in recent years. Progress has been made, but there remains an urgent need to develop stress-tolerant, bio-fortified rice varieties that provide consistent and high-quality yields under both stress and non-stress conditions. Molecular Breeding for Rice Abiotic Stress Tolerance and Nutritional Quality is the first book to provide comprehensive and up-to-date coverage of this critical topic, containing the physiological, biochemical, and molecular information required to develop effective engineering strategies for enhancing rice yield. Authoritative and in-depth chapters examine the molecular and genetic bases of abiotic stress tolerance, discuss yield and quality improvement of rice, and explore new approaches to better utilize natural resources through modern breeding. Topics Include rice adaptation to climate change, enriching rice yields under low phosphorus and light intensity, increasing iron, zinc, vitamin and antioxidant content, and improving tolerance to salinity, drought, heat, cold, submergence, heavy metals and Ultraviolet-B radiation. This important resource: Contains the latest scientific information on a wide range of topics central to molecular breeding for rice Provides timely coverage molecular breeding for improving abiotic stress tolerance, bioavailability of essential micronutrients, and crop productivity through biotechnological methods Features detailed chapters written by internationally-recognized experts in the field Discusses recent progress and future directions in molecular breeding strategies and research Molecular Breeding for Rice Abiotic Stress Tolerance and Nutritional Quality is required reading for rice researchers, agriculturists, and agribusiness professionals, and the ideal text for instructors and students in molecular plant breeding, abiotic stress tolerance, environmental science, and plant physiology, biochemistry, molecular biology, and biotechnology.
Molecular Breeding for Sustainable Crop Improvement
by Vijay Rani Rajpal S. Rama Rao S. N. RainaThe world population is estimated to reach to more than 10 billion by the year 2050. These projections pose a challenging situation for the agricultural scientists to increase crops productivity to meet the growing food demands. The unavailability and/or inaccessibility to appropriate gene pools with desired traits required to carry out genetic improvement of various crop species make this task formidable for the plant breeders. Incidentally, most of the desired genes reside in the wild genetic relatives of the crop species. Therefore, exploration and characterization of wild genetic resources of important crop species is vital for the efficient utilization of these gene pools for sustainable genetic improvements to assure food security. Further, understanding the myriad complexities of genic and genomic interactions among species, more particularly of wild relatives of crop species and/or phylogenetically distant germplasm, can provide the necessary inputs to increase the effectiveness of genetic improvement through traditional and/or genetic engineering methods. This book provides comprehensive and latest insights on the evolutionary genesis of diversity, access and its utilization in the evolution of various crop species. A comprehensive account of various crops, origin, exploitation of the primary, secondary and tertiary gene pools through breeding, biosystematical, cytogenetical and molecular phylogenetical relationships, and genetic enhancement through biotechnological interventions among others have been provided as the necessary underpinnings to consolidate information on the effective and sustainable utilization of the related genetic resources. The book stresses upon the importance of wild germplasm exploration, characterization and exploitation in the assimilation of important crop species. The book is especially intended for students and scientists working on the genetic improvement of crop species. Plant Breeders, Geneticists, Taxonomists, Molecular Biologists and Plant Biotechnologists working on crop species are going to find this book very useful.
Molecular Breeding of Forage and Turf
by Hikmet Budak German SpangenbergThis proceeding covers all the collected research data and presentations from the 8th International Symposium on the Molecular Breeding of Forage and Turf. The book explores themes in molecular breeding of forage and turf, including abiotic and biotic stresses, bioenergy and biorenewables, comparative genomics, emerging tools for forage and turf research, functional genetics and genomics and genetic mapping germplasm, diversity and its impact on breeding, herbage quality, plant-microbe interactions and transgenic and risk assessment. Written by renowned researchers in plant genomics, Molecular Breeding of Forage and Turf: The Proceedings of the 8th International Symposium on the Molecular Breeding of Forage and Turf is a valuable resource for researchers and students in the field of plant genomics.
Molecular Capture: The Animation of Biology (Posthumanities #63)
by Adam NocekHow computer animation technologies became vital visualization tools in the life sciences Who would have thought that computer animation technologies developed in the second half of the twentieth century would become essential visualization tools in today&’s biosciences? This book is the first to examine this phenomenon. Molecular Capture reveals how popular media consumption and biological knowledge production have converged in molecular animations—computer simulations of molecular and cellular processes that immerse viewers in the temporal unfolding of molecular worlds—to produce new regimes of seeing and knowing.Situating the development of this technology within an evolving field of historical, epistemological, and political negotiations, Adam Nocek argues that molecular animations not only represent a key transformation in the visual knowledge practices of life scientists but also bring into sharp focus fundamental mutations in power within neoliberal capitalism. In particular, he reveals how the convergence of the visual economies of science and entertainment in molecular animations extends neoliberal modes of governance to the perceptual practices of scientific subjects. Drawing on Alfred North Whitehead&’s speculative metaphysics and Michel Foucault&’s genealogy of governmentality, Nocek builds a media philosophy well equipped to examine the unique coordination of media cultures in this undertheorized form of scientific media. More specifically, he demonstrates how governmentality operates across visual practices in the biosciences and the popular mediasphere to shape a molecular animation apparatus that unites scientific knowledge and entertainment culture.Ultimately, Molecular Capture proposes that molecular animation is an achievement of governmental design. It weaves together speculative media philosophy, science and technology studies, and design theory to investigate how scientific knowledge practices are designed through media apparatuses.
Molecular Carcinogenesis and the Molecular Biology of Human Cancer
by David Warshawsky Joseph R. LandolphTo gain a complete overview of what is presently known about molecular carcinogenesis would prove to be a very daunting task for those not already steeped in this complex subject. Providing an in-depth summary of the molecular aspects of carcinogenesis, this text comprehensively covers chemical, radiation, and viral carcinogenesis - from animal and human test data to metabolism and DNA binding. It covers organic and metal carcinogenesis related to lung, breast, prostate, skin, liver, colon, brain, and thyroid cancers. The book explores the human implications of data regarding oncogenesis of transgenic and knockout mice and rats. It also covers the genomics and proteomics of chemoprevention, risk and exposure assessments, and regulation of carcinogens. Molecular Carcinogenesis and the Molecular Biology of Human Cancer is an ideal text for graduate courses in cancer.