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Molecular Diagnosis of Genetic Diseases
by Rob EllesMany previous volumes concerned with methodology in human genetics have been written by research scientists and naturally reflect that culture. Molecular Diagnosis of Genetic Diseases aims to diverge from previous titles by presenting contributions that cover a key method in detail, but are set in the context of a diagnostic area or genetic disease. In this format, the book attempts to cover nearly all of the most common genetic disease diagnostics that are offered as services by clinical molecular genetics laboratories, thus contributing a reasonably comprehensive handbook for this type of center. Most of the authors are active scientists working in clinical diagnostics. The methods reflect their working experience in attempting to assure robust, reli able results, and to include essential controls, quality standards, and interpre tive guides. Molecular Diagnosis of Genetic Diseases is primarily aimed at scien tists, clinicians, and technologists working in clinical molecular genetics, especially those working in, or with, diagnostic laboratories. Others who will find the book useful include students and scientific workers at the interface of research genetics and diagnostics, forensic scientists, and biotechnologists. Those concerned with the commercial development of the diagnostic field and with regulation or improvement in standards in molecular genetics, both in professional bodies or government agencies, will also be interested in this book. In addition, scientists planning to develop novel molecular genetic diagnostics in countries with little or no experience in this field will find the book a usefixl starting point.
Molecular Diagnosis of Genetic Diseases, 2nd Edition
by Rob EllesThis completely revised and updated second edition to integrates the many new technologies and insights now available for the diagnosis of genetic diseases. The authors use such methodologies as PCR optimization dosage analysis, mutation scanning, and quantitative fluorescent PCR for aneuploidy analysis, Neurofibromatosis type 1, and Duchenne muscular dystrophy. These largely generic methodologies may be adapted to most genetic conditions for which a molecular diagnosis is relevant, no matter how frequent or rare their incidence. Molecular Diagnosis of Genetic Diseases, Second Edition offers diagnostic molecular geneticists a unique opportunity to sharpen their scientific skills in the design of assays, their execution, and their interpretation.
Molecular Diagnostics
by Sarah Schumacher Harald SeitzIntegration in Bioanalysis: Technologies for Point-of-Care Testing, by Frank F. Bier, Soeren Schumacher Future of Medicine: Models in Predictive Diagnostics and Personalized Medicine, by Babette Regierer, Valeria Zazzu, Ralf Sudbrak, Alexander Kühn and Hans Lehrach A Highly Versatile Microscope Imaging Technology Platform for the Multiplex Real-Time Detection of Biomolecules and Autoimmune Antibodies, by Stefan Rödiger, Peter Schierack, Alexander Böhm, Jörg Nitschke, Ingo Berger, Ulrike Frömmel, Carsten Schmidt, Mirko Ruhland, Ingolf Schimke, Dirk Roggenbuck, Werner Lehmann, Christian Schröder Platform Technologies for Molecular Diagnostics near the Patient's Bedside, by Soeren Schumacher, Christine Lüdecke, Eva Ehrentreich-Förster, Frank F. Bier Microfluidic Technology for Molecular Diagnostics, by Tom Robinson, Petra S. Dittrich Biosensors for Diagnostic Applications, by Friederike J. Gruhl, Bastian E. Rapp, Kerstin Länge Planar Protein Arrays in Microtiter Plates: Development of a New Format Towards Accurate, Automation-Friendly and Affordable (A3) Diagnostics, by Holger Eickhoff, Arif Malik
Molecular Diagnostics for Viral Diseases: Challenges and Emerging Concepts (Medical Virology: From Pathogenesis to Disease Control)
by Aditya Arya Mairaj Ahmed AnsariThis book provides up-to-date information on the molecular diagnosis of viral diseases, including COVID–19, zika virus, human immunodeficiency virus (HIV), viral hepatitis, meningitis, and human papilloma virus (HPV). It covers global trends, the impact of viruses on society, and the need for molecular diagnostics. Initial chapters include information on popular molecular diagnostic methods and up-to-date strategies like Nucleic Acid Testing (NAT) and immunological methods, with an understanding of the challenges in their development. Further chapters emphasize emerging and next-generation diagnostic tools such as Specific High-sensitivity Enzymatic Reporter un-LOCKing (SHERLOCK), DNA Endonuclease Targeted CRISPR Trans Reporter (DETECTR), and Heating Unextracted Diagnostic Samples to Obliterate Nuclease (HUDSON), which boast a sensitivity of up to attomolar. The book also discusses high-end platforms like QIAsymphony. It is supplemented with illustrations and figures to aid conceptual understanding.The book is relevant for researchers in virology, clinicians involved in the therapy of viral diseases, and professionals in pathology labs interested in learning about advanced molecular diagnostic approaches for viral diseases.
Molecular Diagnostics in Dermatology and Dermatopathology
by Michael J. MurphyMolecular Diagnostics in Dermatology and Dermatopathology presents the basics of molecular biology and molecular diagnostic methods most commonly used in the clinical laboratory, with an emphasis on the concepts and testing most relevant to dermatological diseases. Topics include the integration of newer diagnostic and prognostic techniques with 'traditional' histologic approaches, and discussions of regulatory, ethical, legal, economic issues and 'newer' technologies. This important diagnostic tool outlines the clinically relevant uses (i.e.; diagnostic, staging and/or prognostic) applications of these techniques in the field of dermatology. Molecular studies that investigate the pathogenesis of skin diseases will be excluded, unless they also have a direct diagnostic utility. The book will be of interest to practicing pathologists, dermatology and pathology residents, dermatologists, and dermatopathologists.
Molecular Diagnostics: Fundamentals, Methods and Clinical Applications (Second Edition)
by Lela BuckinghamThe textbook, written for students enrolled for Clinical Laboratory Science/Medical Technology programs, explains the principles of molecular technology that are used for diagnostic purposes.
Molecular Diagnostics: Promises and Possibilities
by Mousumi Debnath Prakash S. Bisen Godavarthi B.K.S. PrasadA rapid development in diverse areas of molecular biology and genetic engineering resulted in emergence of variety of tools. These tools are not only applicable to basic researches being carried out world over, but also exploited for precise detection of abnormal conditions in plants, animals and human body. Although a basic researcher is well versed with few techniques used by him/her in the laboratory, they may not be well acquainted with methodologies, which can be used to work out some of their own research problems. The picture is more blurred when the molecular diagnostic tools are to be used by physicians, scientists and technicians working in diagnostic laboratories in hospitals, industry and academic institutions. Since many of them are not trained in basics of these methods, they come across several gray areas in understanding of these tools. The accurate application of molecular diagnostic tools demands in depth understanding of the methodology for precise detection of the abnormal condition of living body. To meet the requirements of a good book on molecular diagnostics of students, physicians, scientists working in agricultural, veterinary, medical and pharmaceutical sciences, it needs to expose the reader lucidly to: Give basic science behind commonly used tools in diagnostics Expose the readers to detailed applications of these tools and Make them aware the availability of such diagnostic tools The book will attract additional audience of pathologists, medical microbiologists, pharmaceutical sciences, agricultural scientists and veterinary doctors if the following topics are incorporated at appropriate places in Unit II or separately as a part of Unit-III in the book. Molecular diagnosis of diseases in agricultural crops Molecular diagnosis of veterinary diseases. Molecular epidemiology, which helps to differentiate various epidemic strains and sources of disease outbreaks. Even in different units of the same hospital, the infections could be by different strains of the same species and the information becomes valuable for infection control strategies. Drug resistance is a growing problem for bacterial, fungal and parasitic microbes and the molecular biology tools can help to detect the drug resistance genes without the cultivation and in vitro sensitivity testing. Molecular diagnostics offers faster help in the selection of the proper antibiotic for the treatment of tuberculosis, which is a major problem of the in the developing world. The conventional culture and drug sensitivity testing of tuberculosis bacilli is laborious and time consuming, whereas molecular diagnosis offers rapid drug resistant gene detection even from direct clinical samples. The same approach for HIV, malaria and many more diseases needs to be considered. Molecular diagnostics in the detection of diseases during foetal life is an upcoming area in the foetal medicine in case of genetic abnormalities and infectious like TORCH complex etc. The book will be equally useful to students, scientists and professionals working in the field of molecular diagnostics.
Molecular Dissection of Complex Traits
by Andrew H. PatersonIn the past 10 years, contemporary geneticists using new molecular tools have been able to resolve complex traits into individual genetic components and describe each such component in detail. Molecular Dissection of Complex Traits summarizes the state of the art in molecular analysis of complex traits (QTL mapping), placing new developments in thi
Molecular Diversity of Environmental Prokaryotes
by Thiago Bruce Rodrigues and Amaro Emiliano Trindade SilvaThis book correlates the vast genetic diversity associated with environmental samples and still underexploited potential for the development of biotechnology products. The book points out the potential of different types of environmental samples. It presents the main characteristics of microbial diversity, the main approaches used for molecular characterization of the diversity, and practical examples of application of the exploration of the microbial diversity. It presents a not-yet-explored structure for discussing the main topics related to molecular biology of environmental prokaryotes and their biotechnological applications.
Molecular Driving Forces: Statistical Thermodynamics in Biology, Chemistry, Physics, and Nanoscience
by Ken Dill Sarina BrombergMolecular Driving Forces, Second Edition E-book is an introductory statistical thermodynamics text that describes the principles and forces that drive chemical and biological processes. It demonstrates how the complex behaviors of molecules can result from a few simple physical processes, and how simple models provide surprisingly accurate insights into the workings of the molecular world. Widely adopted in its First Edition, Molecular Driving Forces is regarded by teachers and students as an accessible textbook that illuminates underlying principles and concepts. The Second Edition includes two brand new chapters: (1) "Microscopic Dynamics" introduces single molecule experiments; and (2) "Molecular Machines" considers how nanoscale machines and engines work. "The Logic of Thermodynamics" has been expanded to its own chapter and now covers heat, work, processes, pathways, and cycles. New practical applications, examples, and end-of-chapter questions are integrated throughout the revised and updated text, exploring topics in biology, environmental and energy science, and nanotechnology. Written in a clear and reader-friendly style, the book provides an excellent introduction to the subject for novices while remaining a valuable resource for experts.
Molecular Dynamics
by Charles Matthews Ben LeimkuhlerThis book describes the mathematical underpinnings of algorithms used for molecular dynamics simulation, including both deterministic and stochastic numerical methods. Molecular dynamics is one of the most versatile and powerful methods of modern computational science and engineering and is used widely in chemistry, physics, materials science and biology. Understanding the foundations of numerical methods means knowing how to select the best one for a given problem (from the wide range of techniques on offer) and how to create new, efficient methods to address particular challenges as they arise in complex applications. Aimed at a broad audience, this book presents the basic theory of Hamiltonian mechanics and stochastic differential equations, as well as topics including symplectic numerical methods, the handling of constraints and rigid bodies, the efficient treatment of Langevin dynamics, thermostats to control the molecular ensemble, multiple time-stepping, and the dissipative particle dynamics method.
Molecular Dynamics
by Ruben SantamariaThis molecular dynamics textbook takes the reader from classical mechanics to quantum mechanics and vice versa, and from few-body systems to many-body systems. It is self-contained, comprehensive, and builds the theory of molecular dynamics from basic principles to applications, allowing the subject to be appreciated by readers from physics, chemistry, and biology backgrounds while maintaining mathematical rigor. The book is enhanced with illustrations, problems and solutions, and suggested reading, making it ideal for undergraduate and graduate courses or self-study. With coverage of recent developments, the book is essential reading for students who explore and characterize phenomena at the atomic level. It is a useful reference for researchers in physics and chemistry, and can act as an entry point for researchers in nanoscience, materials engineering, genetics, and related fields who are seeking a deeper understanding of nature.
Molecular Dynamics - Theory and Applications (Mechanical Engineering Series)
by Maurizio Bottoni Simone Mantovani Gaetano ZanghiratiThis book originated from seminars given at the Institute of Nuclear Energy Technology (INET) of Tsinghua University, China, by the author in 1999. The courses gave graduate students a basic understanding of numerical techniques that would enable them to deal with problems of Computational Fluid Dynamics (CFD) and of molecular dynamics at research level. In subsequent years the lecture notes have been re-organized and implemented for students of atmospheric sciences of the Physics Department of the University of Ferrara, Italy. The lecture notes are divided into eight chapters, where some chapters are characterized by a scholastic approach. Specifically, Chapter 1 describes the theoretical basis of molecular dynamics, Chapter 2 gives examples of applications, like the Bénard problem; and Chapter 3 presents a summary of applications of DLA (Diffusion Limited Aggregation). The remainder of the book follows a less conventional approach, mainly informed by the author’s experience in the development of computer programs and in teaching. Chapter 4 is dedicated to a comparison of traditional and advanced methods of analysing nuclear safety problems in thermal and fast reactors, Chapter 5 concerns simulation of thermophoresis and aerosol displacement in atmospheric physics, and Chapter 6 discusses thermal confinement of cosmic particles due to thermophoretic forces in space domain. Addressing the recognized difficulty of proceeding from the theoretical formulations found in textbooks to properly working computer programs, and the typically large gap between the theoretical foundation and the final result, Molecular Dynamics - Theory and Applications is ideal for graduate level researchers and practitioners working in the development of codes for simulating physical problems.
Molecular Dynamics Analyses of Prion Protein Structures: The Resistance to Prion Diseases Down Under (Focus on Structural Biology #10)
by Jiapu ZhangUnlike bacteria and viruses, which are based on DNA and RNA, prions are unique as disease-causing agents since they are misfolded proteins. Prion diseases are called "protein structural conformational” diseases. This monograph is the book on molecular dynamics (MD) simulations nearly for all the known normal prion protein (PrPC) PDB entries in the Protein Data Bank (PDB) and associations. Pig is a species that is largely resistant to prions, and chicken, turtles, frogs are species resisting prion infection too; firstly, this book will address all PrP strong immunity species (such as rabbits, dogs, horses, water buffaloes, pigs, chicken, turtles, frogs), compared with high susceptibility species. Other PrP models and doppel models are also MD studied in this book.Secondly, all the mutants of mouse PrP and human PrP are well studied by this book. Mouse mutations in the β2-α2 loop and the C-terminal will bring clear structures with highly and clearly ordered loop structures. Human mutations will cause prion diseases such as Creutzfeldt-Jakob diseases (CJDs), Gerstmann-Sträussler-Scheinker (GSS) syndrome, fatal familial insomnia (FFI), etc. Deep MD analyses of mouse and human mutants are done in this book.Thirdly, PrP binding with antibodies/compounds etc. is well MD studied in this book. The informatics of potential antiprion drugs known will be revealed. Lastly, cross-β structure PrP peptides are well studied. This book is ideal for practical computing staff in the fields of computational physics, computational biology, computational chemistry, biomedicine, bioinformatics, cheminformatics, materials, applied mathematics and theoretical physics, information technology, operations research, biostatistics, etc. As an accessible introduction to these fields, this book is also ideal as a teaching material for students.
Molecular Dynamics Simulation of Nanostructured Materials: An Understanding of Mechanical Behavior
by Bankim Chandra Ray Snehanshu PalMolecular dynamics simulation is a significant technique to gain insight into the mechanical behavior of nanostructured (NS) materials and associated underlying deformation mechanisms at the atomic scale. The purpose of this book is to detect and correlate critically current achievements and properly assess the state of the art in the mechanical behavior study of NS material in the perspective of the atomic scale simulation of the deformation process. More precisely, the book aims to provide representative examples of mechanical behavior studies carried out using molecular dynamics simulations, which provide contributory research findings toward progress in the field of NS material technology.
Molecular Dynamics Simulations in Statistical Physics: Theory and Applications (Scientific Computation)
by Hiqmet KamberajThis book presents computer simulations using molecular dynamics techniques in statistical physics, with a focus on macromolecular systems. The numerical methods are introduced in the form of computer algorithms and can be implemented in computers using any desired computer programming language, such as Fortran 90, C/C++, and others. The book also explains how some of these numerical methods and their algorithms can be implemented in the existing computer programming software of macromolecular systems, such as the CHARMM program. In addition, it examines a number of advanced concepts of computer simulation techniques used in statistical physics as well as biological and physical systems. Discussing the molecular dynamics approach in detail to enhance readers understanding of the use of this method in statistical physics problems, it also describes the equations of motion in various statistical ensembles to mimic real-world experimental conditions. Intended for graduate students and research scientists working in the field of theoretical and computational biophysics, physics and chemistry, the book can also be used by postgraduate students of other disciplines, such as applied mathematics, computer sciences, and bioinformatics. Further, offering insights into fundamental theory, it as a valuable resource for expert practitioners and programmers and those new to the field.
Molecular Dynamics Simulations of Disordered Materials
by Carlo Massobrio Jincheng Du Marco Bernasconi Philip S. SalmonThis book is a unique reference work in the area of atomic-scale simulation of glasses. For the first time, a highly selected panel of about 20 researchers provides, in a single book, their views, methodologies and applications on the use of molecular dynamics as a tool to describe glassy materials. The book covers a wide range of systems covering "traditional" network glasses, such as chalcogenides and oxides, as well as glasses for applications in the area of phase change materials. The novelty of this work is the interplay between molecular dynamics methods (both at the classical and first-principles level) and the structure of materials for which, quite often, direct experimental structural information is rather scarce or absent. The book features specific examples of how quite subtle features of the structure of glasses can be unraveled by relying on the predictive power of molecular dynamics, used in connection with a realistic description of forces.
Molecular Dynamics and Complexity in Catalysis and Biocatalysis
by Marco PiumettiThis textbook presents a concise comparison of catalytic and biocatalytic systems outlining their catalytic properties and peculiarities. Moreover, it presents a brief introduction to the science of catalysis and attempts to unify different catalytic systems into a single, conceptually coherent structure. In fact, molecular dynamics and complexity may occur in both catalysts and biocatalysts, with many similarities in both their structural configuration and operational mechanisms. Moreover, the interactions between the different components of the catalytic system that are important in defining the overall activity, including the nature of active sites are discussed. Each chapter includes end of chapter questions supported by an online instructor solution manual. This textbook will be useful for undergraduate and graduate chemistry and biochemistry students.
Molecular Dynamics of Additives in Polymers
by Alexander KovarskiThis volume focuses on the dynamical behaviour of low-molecular additives in solid polymer matrixes. It covers: types and models of molecular motion in condensed media; dependence of motional frequency on particle structure and size, temperature, volume and stress; and polymer properties and polymeric structures. Extensive analysis of common regularities of rotational and translational dynamics of molecules introduced into polymers are given. The book also includes experimental techniques for molecular mobility evaluation, and features detailed data on rotational dynamics of additives. It should be of interest to specialists in various fields of polymer physical chemistry and materials science.
Molecular Dynamics of Glass-Forming Systems
by Marian Paluch George Floudas Kai Ngai Andrzej GrzybowskiPressure is one of the essential thermodynamic variables that, due to some former experimental difficulties, was long known as the "forgotten variable." But this has changed over the last decade. This book includes the most essential first experiments from the 1960s and reviews the progress made in understanding glass formation with the application of pressure in the last ten years. The systems include amorphous polymers and glass-forming liquids, polypeptides and polymers blends. The thermodynamics of these systems, the relation of the structural relaxation to the chemical specificity, and their present and future potential applications are discussed in detail. The book provides (a) an overview of systems exhibiting glassy behavior in relation to their molecular structure and provides readers with the current state of knowledge on the liquid-to-glass transformation, (b) emphasizes the relation between thermodynamic state and dynamic response and (c) shows that the information on the pressure effects on dynamics can be employed in the design of materials for particular applications. It is meant to serve as an advanced introductory book for scientists and graduate students working or planning to work with dynamics. Several scientific papers dealing with the effects of pressure on dynamics have appeared in leading journals in the fields of physics in the last ten years. The book provides researchers and students new to the field with an overview of the knowledge that has been gained in a coherent and comprehensive way.
Molecular Dynamics of Plant Stress and its Management
by Muhammad Shahid Rajarshi GaurThis edited volume focuses on the study of stress in plants and how it can be effectively managed. With the growing global population, the importance of crop yield and stress management has become a critical issue, and this book offers solutions to these challenges. The book explores the impact of abiotic and biotic stressors on plant growth and development, including drought, salinity, temperature stress, pests, and diseases. It also examines the role of genetic engineering and biotechnology in developing stress-tolerant plants. It offers insights on the latest research and advancements in plant breeding, genomics, and proteomics, which are essential in developing crops that can withstand harsh environmental conditions. It offers solutions for managing these challenges, including genetic engineering, proteomics, and genomics. The book provides a detailed overview of the latest research and advancements in plant stress management and offers practical advice on how to apply these findings in real-world scenarios. It explores the impact of climate change on agricultural production and provides insights on how to develop stress-tolerant crops that can withstand changing environmental conditions. With its comprehensive coverage of the latest research and practical insights, the book is an invaluable guide for students, researchers, and professionals looking to develop sustainable agricultural practices and ensure food security for future generations.
Molecular Ecology
by Heather Kirk Joanna R. Freeland Stephen D. PetersenMolecular Ecology, 2nd Edition provides an accessible introduction to the many diverse aspects of this subject. The book takes a logical and progressive approach to uniting examples from a wide range of taxonomic groups. The straightforward writing style offers in depth analysis whilst making often challenging subjects such as population genetics and phylogenetics highly comprehensible to the reader.The first part of the book introduces the essential underpinnings of molecular ecology and gives a review of genetics and discussion of the molecular markers that are most frequently used in ecological research, and a chapter devoted to the newly emerging field of ecological genomics. The second half of the book covers specific applications of molecular ecology, covering phylogeography, behavioural ecology and conservation genetics.The new edition provides a thoroughly up-to-date introduction to the field, emphasising new types of analyses and including current examples and techniques whilst also retaining the information-rich, highly readable style which set the first edition apart.Incorporates both theoretical and applied perspectivesHighly accessible, user-friendly approach and presentationIncludes self-assessment activities with hypothetical cases based on actual species and realistic data setsUses case studies to place the theory in contextProvides coverage of population genetics, genomics, phylogeography, behavioural ecology and conservation genetics.
Molecular Ecology
by Joanna R. FreelandA fully updated guide to the increasingly prevalent use of molecular data in ecological studies Molecular ecology is concerned with how molecular biology and population genetics may help us to better understand aspects of ecology and evolution including local adaptation, dispersal across landscapes, phylogeography, behavioral ecology, and conservation biology. As the technology driving genetic science has advanced, so too has this fast-moving and innovative discipline, providing important insights into virtually all taxonomic groups. This third edition of Molecular Ecology takes account of the breakthroughs achieved in recent years to give readers a thorough and up-to-date account of the field as it is today. New topics covered in this book include next-generation sequencing, metabarcoding, environmental DNA (eDNA) assays, and epigenetics. As one of molecular ecology’s leading figures, author Joanna Freeland also provides those new to the area with a full grounding in its fundamental concepts and principles. This important text: Is presented in an accessible, user-friendly manner Offers a comprehensive introduction to molecular ecology Has been revised to reflect the field’s most recent studies and research developments Includes new chapters covering topics such as landscape genetics, metabarcoding, and community genetics Rich in insights that will benefit anyone interested in the ecology and evolution of natural populations, Molecular Ecology is an ideal guide for all students and professionals who wish to learn more about this exciting field.
Molecular Ecology and Conservation Genetics of Neotropical Mammals
by Maximiliano Nardelli Juan Ignacio TúnezAlthough all living beings modify their environment, human beings have acquired the ability to do so on a superlative space-time scale. As a result of industrialization and the use of new technologies, the anthropogenic impact has been increasing in the last centuries, causing reductions in the sizes or the extinction of numerous wild populations. In this sense, from the field of conservation genetics, various efforts have been made in recent decades to provide new knowledge that contributes to the conservation of populations, species, and habitats. In this book, we summarize the concrete contributions of researchers to the conservation of the Neotropical mammals using Molecular Ecology techniques.The book is divided into three major sections. The first section provides an up-to-date review of the conservation status of Neotropical mammals, the applications of the molecular markers in its conservation, and the use of non-invasive and forensic genetic techniques. The second and third sections present, respectively, a series of case studies in various species or taxonomic groups of Neotropical mammals.
Molecular Electronic Control Over Tunneling Charge Transfer Plasmons Modes (Springer Theses)
by Shu Fen TanThis thesis describes the controlled immobilization of molecules between two cuboidal metal nanoparticles by means of a self-assembly method to control the quantum plasmon resonances. It demonstrates that quantum-plasmonics is possible at length scales that are useful for real applications. Light can interact with certain metals and can be captured in the form of plasmons, which are collective, ultra-fast oscillations of electrons that can be manipulated at the nano-scale. Surface plasmons are considered as a promising phenomenon for potentially bridging the gap between fast-operating-speed optics and nano-scale electronics. Quantum tunneling has been predicted to occur across two closely separated plasmonic resonators at length scales ( Unlike top-down nanofabrication, the molecules between the closely-spaced metal nanoparticles could control the gap sizes down to sub-nanometer scales and act as the frequency controllers in the terahertz regime, providing a new control parameter in the fabrication of electrical circuits facilitated by quantum plasmon tunneling.