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Mr. Harrison Is Embarrassin’! (My Weirder School #2)
by Dan Gutman Jim PaillotMy Weirder School weirder than ever!Mr. Harrison, the tech guy at Ella Mentry School, can fix anything: computers, phones, pencil sharpeners. He can also build anything, like a solar-powered umbrella. What a nerd! But when the power goes out in the school, everyone is yelling and screaming and freaking out in the dark. Can Mr. Harrison save the day?
MR Imaging of the Fetus
by R. RajeswaranThis book presents the anatomy and MRI features of the normal fetus and describes the anomalies of each system in a systematic way. The normal fetal brain at different gestational ages is also extensively illustrated. It features a treasure of MR images illustrating several clinical conditions. Sonographic images, line diagrams and post-natal images are supplemented for easy learning. It also addresses the differential diagnoses and prognostic indicators of the various fetal anomalies.This book will help the consultants and postgraduates of radiology, obstetrics, fetal medicine and pediatrics in understanding various fetal anomalies and in patient counseling.
Mr. Jefferson and the Giant Moose: Natural History in Early America
by Lee Alan DugatkinIn the years after the Revolutionary War, the fledgling republic of America was viewed by many Europeans as a degenerate backwater, populated by subspecies weak and feeble. Chief among these naysayers was the French Count and world-renowned naturalist Georges-Louis Leclerc de Buffon, who wrote that the flora and fauna of America (humans included) were inferior to European specimens. Thomas Jefferson--author of the Declaration of Independence, U. S. president, and ardent naturalist--spent years countering the French conception of American degeneracy. His Notes on Virginia systematically and scientifically dismantled Buffon's case through a series of tables and equally compelling writing on the nature of his home state. But the book did little to counter the arrogance of the French and hardly satisfied Jefferson's quest to demonstrate that his young nation was every bit the equal of a well-established Europe. Enter the giant moose. The American moose, which Jefferson claimed was so enormous a European reindeer could walk under it, became the cornerstone of his defense. Convinced that the sight of such a magnificent beast would cause Buffon to revise his claims, Jefferson had the remains of a seven-foot ungulate shipped first class from New Hampshire to Paris. Unfortunately, Buffon died before he could make any revisions to his Histoire Naturelle,but the legend of the moose makes for a fascinating tale about Jefferson's passion to prove that American nature deserved prestige. In Mr. Jefferson and the Giant Moose,Lee Alan Dugatkin vividly recreates the origin and evolution of the debates about natural history in America and, in so doing, returns the prize moose to its rightful place in American history.
MR Spectroscopy of Pediatric Brain Disorders
by Ashok Panigrahy Stefan BlümlMagnetic resonance spectroscopy (MRS) is a modality available on most clinical MR scanners and readily integrated with standard MR imaging (MRI). For the brain in particular, MRS has been a powerful research tool providing additional clinically relevant information for several disease families such as brain tumors, metabolic disorders, and systemic diseases. The most widely-available MRS method, proton (1H; hydrogen) spectroscopy, is FDA approved for general use in the US and can be ordered by clinicians for patient studies if indicated. There are several books available that describe applications of MRS in adults. However, to the best of our knowledge there is currently no book available that focuses exclusively on applications in pediatrics. MR spectroscopy in the pediatric population is different from adults for two main reasons. Particularly in the newborn phase the brain undergoes biochemical maturation with dramatic changes of the "normal" biochemical fingerprint. Secondly, brain diseases in the pediatric population are different from adult disorders. For example, brain tumors, which are mostly gliomas in the adults, often originate from different cell types and are also more diverse even within the same type and grade of tumor. This diversity of diseases and its implications for MR spectroscopy has not been addressed sufficiently in the literature, we believe. The target audience for "MR Spectroscopy of Pediatric Brain Disorders" are thus both clinicians and researchers involved with pediatric brain disorders. This includes radiologists, neurologists, neurooncologists, neurosurgeons, and more broadly the neuroscience and neurobiology community. This book will provide the necessary background information to understand the basics of MR spectroscopy. This will be followed by a detailed discussion of the normal biochemical maturation which will highlight the metabolic differences between the pediatric and adult brain. Thereafter, in SECTION I individual chapters will address various pediatric brain disease families. Of particular importance for pediatrics are case studies. For that reason, SECTION II will contain a large number of case studies. This will be particularly important for clinicians who may want to see examples of MRS for various conditions. A standardized format will be used for case reports that allow the reader to quickly understand the history of each case presented and the significance of the findings. The case reports will also include information from other imaging modalities to point out any added value of MRS in addition to conventional studies and clinical information. This section is necessary because the format of providing more complete information about individual patients is not practical for the chapters in SECTION I.
Mr Tompkins in Paperback
by George GamowSince his first appearance over sixty years ago, Mr Tompkins has become known and loved by many thousands of readers as the bank clerk whose fantastic dreams and adventures lead him into a world inside the atom. George Gamow's classic provides a delightful explanation of the central concepts in modern physics, from atomic structure to relativity, and quantum theory to fusion and fission. Roger Penrose's foreword introduces Mr Tompkins to a new generation of readers, and reviews his adventures in light of recent developments in physics.
Mr. Tony Is Full of Baloney! (My Weird School Daze #11)
by Dan Gutman Jim PaillotThe weirdness never stops! Oh no! A.J.'s mom just got a job, so he has to go to After School Kids' Kare. And Mr. Tony, the guy who runs it, is crazy. He wants to get into the Guinness Book of World Records by making the world's largest pizza! Will A.J. and the gang be able to tunnel out of the child-care room and escape to freedom? Run for your lives!
MRI from A to Z
by Gary LineyThis second edition of Gary Liney's MRI from A-Z, much expanded from the first edition, is both a reflection of and an apt companion for the dramatic growth of the field of MRI. The MRI-trainee to the most seasoned practitioner in MRI will find this A-Z of the field, with 1,300 entries and 100 illustrations, an indispensable reference tool. Providing the reader with concise, clear and eloquent definitions of MRI terminology, this book is both highly practical and a pleasure to read.
MRI Handbook
by Muhammed Elmaoğlu Azim ÇelikMRI Handbook presents a concise review of the physical principles underlying magnetic resonance imaging (MRI), explaining MR physics, patient positioning, and protocols in an easy-to-read format. The first five chapters of the book introduce the reader to the basics of MR imaging, including the relaxation concept, MR pulse sequences, and MR imaging parameters and options. The second part of the book (chapters 6-11) uses extensive illustrations, images, and protocol tables to explain tips and tricks to achieve optimal MR image quality while ensuring patient safety. Individual chapters are devoted to each major anatomic region, including the central nervous, musculoskeletal, and cardiovascular systems. By using annotated MR images and examples of patient positions used during scanning correlated with sample protocols and parameters, MRI Handbook is a practical resource for imaging professionals to use in the course of their daily practice as well as for students to learn the basic concepts of MR imaging.
MRI in Epilepsy
by Horst UrbachMRI can play an important role in identifying and localizing epileptogenic foci. This book aims to provide the clinical and imaging information required in order to decide whether an MRI scan is appropriate and whether it is likely to be sufficient to detect a lesion. The first part of the book presents background information on epilepsy patients and explains how to perform an MRI examination. Detailed attention is paid to functional MRI and post-processing, and the examination of subcategories of patients is also discussed. The second part of the book then documents the MRI findings obtained in the full range of epileptogenic lesions with the aid of high-quality images. Throughout, emphasis is placed on guiding the reader in the correct interpretation of the imaging findings. Both radiologists and referring physicians will find this book to be an indispensable guide to the optimal use of MRI in epilepsy.
MRI of Cardiovascular Malformations
by Bruno KastlerMRI is a non-invasive and non-ionizing imaging modality that is perfectly suited for the diagnosis and follow-up of both pediatric and adult congenital heart disease. It provides a large field of view and has the unique ability to depict complex cardiac and vascular anatomy and to measure cardiac function and flow within one examination. MRI is the ideal complement to echocardiography whenever the information provided by the latter is limited. This book has been conceived as a self-teaching manual that will assist qualified radiologists, cardiologists, and pediatricians, as well as those in training. It is richly illustrated with numerous images and drawings that cover all usual and most unusual anomalies. The principal author, Professor Bruno Kastler, is head of radiology at Besançon University Hospital, France and is board certified in both radiology and cardiology.
MRI of Degenerative Disease of the Spine: A Case-Based Atlas
by Paola D'Aprile Alfredo TarantinoThis is the second edition of an acclaimed, richly illustrated and comprehensive case-based atlas focusing on MRI of degenerative changes in the osteoarticular structures of the spine. Spinal degenerative disease is highly prevalent in the general population and its incidence increases with age. At the same time, degenerative spinal conditions are one of the most common causes of pain.The book presents a comprehensive overview of the MR findings observed in degenerative disease of spinal joints, ligaments and paravertebral muscles, and offers guidance on selecting the appropriate imaging protocol, which is critical in detecting the potentially very subtle changes. The MR study protocols presented include T2-weighted sequences with fat saturation and contrast-enhanced T1-weighted sequences with fat saturation, since these sequences permit better visualization of inflammatory changes of both anterior and posterior elements of the spine.This richly illustrated second edition highlights the inflammatory component of the degenerative pathology of the spine, which in most cases is responsible for the painful symptomatology. It also discusses in detail the use of contrast medium in MRI of spinal degenerative disease. The “case-based” structure of the atlas allows easy but effective consultation by radiologists, neuroradiologists, rheumatologists, orthopedists and physiatrists, as well as students.
MRI of Gynaecological Diseases: Illustrations and Cases
by Guofu ZhangThis book systematically covers MRI imaging findings of a spectrum of gynaecological diseases, including ovarian cysts, uterine fibroids, cervical cancer, and endometrial cancer, etc. All chapters are arranged in the same format: simply clinical history is firstly presented in order to help readers mimic the real clinical scenario, and then untypical features in many common diseases and typical features in many uncommon diseases are interpreted. In the end of each chapter, tips in differential diagnosis were summarized by analysing a class of cases with similar imaging performance. All cases in the book have the detailed pathological results, and the pathological specimens are also shown in some cases. It will be an ideal reference for physicians involved in the diagnosis and treatment of gynaecological diseases.
MRI of Rectal Cancer
by Mathias Langer Arnd-Oliver SchäferToday magnetic resonance imaging (MRI) of rectal cancer is one of the most interesting topics in radiology. Over the last decade technical refinements have strengthened the role of MRI as a first-line diagnostic strategy for accurate staging of rectal cancer. MRI is perfectly suited to predict tumor-free circumferential resection margins. Additionally, high accuracies have been reported for the T and N stages, which is comparable to transrectal ultrasound (TRUS). Novel approaches to moving table MRI serve as a platform for thoracic, abdominal and pelvic staging of rectal cancer patients within one examination. The broad spectrum of high-quality illustrations and the contribution of clinical experts provide substantial insight into the sophisticated field of rectal cancer management.
MRI of Short and Ultrashort-T_2 Tissues: Making the Invisible Visible
by Jiang Du Graeme M. BydderThis book comprehensively covers ultrashort echo time (UTE), zero echo time (ZTE), and other magnetic resonance imaging (MRI) acquisition techniques for imaging of short and ultrashort-T2 tissues. MRI uses a large magnet and radio waves to generate images of tissues in the body. The MRI signal is characterized by two time constants, spin-lattice relaxation time (T1) which describes how fast the longitudinal magnetization recovers to its initial value after tipping to the transverse plane, and spin-spin relaxation time (T2) which describes how fast the transverse magnetization decays. Conventional MRI techniques have been developed to image and quantify tissues with relatively long T2s. However, the body also contains many tissues and tissue components such as cortical bone, menisci, ligaments, tendons, the osteochondral junction, calcified tissues, lung parenchyma, iron containing tissues, and myelin, which have short or ultrashort-T2s. These tissues are “invisible” with conventional MRI, and their MR and tissue properties are not measurable. UTE and ZTE type sequences resolve these challenges and make these tissues visible and quantifiable.This book first introduces the basic physics of conventional MRI as well as UTE and ZTE type MRI, including radiofrequency excitation, data acquisition, and image reconstruction. A series of contrast mechanisms are then introduced and these provide high resolution, high contrast imaging of short and ultrashort-T2 tissues. A series of quantitative UTE imaging techniques are described for measurement of MR tissue properties (proton density, T1, T2, T2*, T1p,magnetization transfer, susceptibility, perfusion and diffusion). Finally, clinical applications in the musculoskeletal, neurological, pulmonary and cardiovascular systems are described.This is an ideal guide for physicists and radiologists interested in learning more about the use of UTE and ZTE type techniques for MRI of short and ultrashort-T2 tissues.
MRI of the Gastrointestinal Tract
by Jaap StokerMRI has become an important tool in the management of patients with diseases of the gastrointestinal tract, such as rectal cancer and inflammatory bowel diseases. This book, written by distinguished experts in the field, discusses in detail the technical, practical, and clinical aspects of MRI of the gastrointestinal tract. The chapters on technique encompass the most recent developments and address such topics as contrast media, high field strength MRI, and perfusion MRI. Subsequently, individual chapters are devoted to the clinical applications of MRI in the different parts of the gastrointestinal tract. Both established applications and new frontiers are considered, with the aid of numerous high-quality illustrations. By combining chapters dedicated to technical aspects and clinically oriented chapters, this book will prove very instructive for the novice while simultaneously offering experienced practitioners further insights into the value of MRI of the gastrointestinal tract.
MRI of the Spine: A Guide for Orthopedic Surgeons
by William B. Morrison John A. Carrino Adam E. FlandersUtilizing plentiful radiological images to illustrate each topic, this text is a comprehensive and descriptive review of magnetic resonance imaging (MRI) interpretation for the spine, emphasizing standardized nomenclature and grading schemes. The book begins with current MR imaging protocols, including indication, sequencing and advanced imaging techniques, and a review of the relevant anatomy of the spine and its anomalies. Subsequent chapters encompass topics of trauma, degenerative disease, infection, inflammatory disease, as well as neoplastic and metabolic disease. Spinal cord and dural lesions will also be presented, with additional chapters dedicated to MRI evaluation of the post-operative patient. The format is reader-friendly, utilizing an efficient presentation of the essential principles and important findings on MR images of the spine, with a wealth of high-quality figures, graphics and tables for differential diagnosis as well as tips and tricks from experts in the field. Presenting the most up-to-date protocols and suggested interpretations, MRI of the Spine will be a solid reference for orthopedic surgeons, sports medicine specialists, neurosurgeons, radiologists and all clinicians and support staff caring for the spine.
MRI of the Temporomandibular Joint: Correlation Between Imaging and Pathology
by Tiziana Robba Carlotta Tanteri Giulia TanteriThis book is the outcome of a fruitful, long-standing cooperation between expert radiologists and clinicians, and explains the most relevant features and technical requirements that are needed to optimally conduct and assess MR examinations for temporomandibular joint (TMJ) pathologies. TMJ conditions are increasingly gaining attention, as the underlying diseases involved can vary considerably and be difficult to diagnose. Similarly, several imaging sub-specialties (e.g. dental radiology, neuroradiology, and musculoskeletal radiology) now find themselves dealing with the temporomandibular joints. The authors provide essential information on TMJ anatomy, dynamics, function and dysfunction. Correlations between clinical aspects and MRI findings are discussed and guidance for the correct interpretation of results is offered. Special findings that are helpful for differential diagnosis (arthritis, osteochondroma, synovial chondromatosis) are also examined. Given its extensive and varied coverage, the book offers a valuable asset for radiologists, dentists, gnathologists, maxillofacial surgeons, orthodontists and other professionals seeking a thorough overview of the subject
MRI of the Upper Extremity: Elbow, Wrist, and Hand
by Bethany U. CasagrandaThis book systematically discusses the anatomy and pathology of three specific regions of the upper extremity: the elbow, wrist, and hand. Divided into three sections, by body part, chapters cover anatomy and pathology. The anatomy chapters give a comprehensive view of each body part and normal variants found there. Although the primary modality emphasized will be MRI, illustrations and other modalities, including plain radiograph and CT, will be used to comprehensively discuss the anatomy of each region. Liberally illustrated, the pathology chapters then cover both traumatic and non-traumatic causes for imaging and detail how to perform and interpret each MRI. Specific examples include: osseous trauma, soft tissue trauma, and tumor imaging. Chapters are written with the deliberate intention to be of value to all levels of radiology training while remaining a reliable resource for attending radiologists.
MRI of the Whole Body: An Illustrated Guide for Common Pathologies
by Nikhil Bhuskute Edward Hoey Amit Lakkaraju Kshitij MankadThe optimal use of magnetic resonance imaging poses a constant challenge as the technology is continually and rapidly advancing. This leaves the MR practitioner, beginner or experienced, in constant need of up-to-date, easily read and well illustrated material presenting the clinical constellation of pathologies as seen by an MRI scanner in such an
The mRNA Metabolism in Human Disease (Advances in Experimental Medicine and Biology #1157)
by Luísa RomãoThe eukaryotic gene expression pathway involves a number of interlinked steps, with messenger RNA (mRNA) being the key intermediate. The precursor mRNA is transcribed from DNA, processed by removal of introns and addition of the cap structure and the poly(A) tail. The mature mRNA is then exported to the cytoplasm where it is translated into protein and finally degraded. In this process, mRNA is associated with RNA-binding proteins forming ribonucleoprotein complexes, whose protein content evolves throughout the lifetime of the mRNA. While the complexity of eukaryotic gene expression allows the production of proteins to be controlled at many levels, it also makes the process vulnerable to errors. Although eukaryotic cells have evolved elaborate mRNA quality control mechanisms that ensure the fidelity of gene expression, some defects are not detected, thus affecting mRNA metabolism. This condition plays a fundamental role in the pathogenesis of several disease processes, such as neurodegeneration and oncogenesis. Besides, exciting recent data have shown that cellular RNAs can be modified post-transcriptionally via dynamic and reversible chemical modifications, the so-called epitranscriptome. These modifications can alter mRNA structure, being able to modulate different steps of the mRNA metabolism that can be associated with various human diseases, such as systemic lupus erythematosus and cancer. This book provides a collection of novel studies and hypotheses aimed to define the pathophysiological consequences of altered mRNA metabolism events in human cells, and is written for a wide spectrum of readers in the field of gene expression regulation. The last chapter highlights how the discovery of disease-causing defects (or modifications) in mRNA can provide a variety of therapeutic targets that can be used for the development of new RNA-based therapeutics. Hopefully, it may also contribute to inspire the drug-developing scientific community.
mRNA Processing and Metabolism
by Daniel R. SchoenbergA collection of readily reproducible techniques for the study of mRNA processing and metabolism. These cutting-edge techniques range from cotranscriptional processing events that occur while the mNA is engaged with elongating RNA polymerase II, to in vivo and in vitro splicing and its biochemical analysis, and alternative splicing. Additional methods cover mRNA export, the recovery and analysis of mRNP complexes, cytoplasmic translation, mRNA degradation in vivo and in vitro, and the controversial concept of nuclear translation. Each proven protocol is described in step-by-step detail and contains a background introduction outlining the principle behind the technique, lists of equipment and reagents, and tips on troubleshooting and avoiding know pitfalls.
mRNA Therapeutics: Fast-to-Market Strategies
by Sarfaraz K. NiaziThis book is the most comprehensive and complete treatise on nucleic acid therapeuticproducts, including mRNA vaccines, their manufacturing, formulations, andtesting for safety and efficacy. Details include cGMP-compliant manufacturing andregulatory filing steps. A new concept of “biosimilar” mRNA vaccine is presentedto secure fast approval of copies of mRNA vaccines. Projections of financial plansto establish RNA manufacturing facilities are provided, along with details of supplychain management. Finally, the future of nucleic acid products in gene therapy andother newer applications is presented, along with a perspective that all new vaccineswill be the nucleic acid type that will further provide first-time prevention of autoimmunedisorders. It is projected that both big pharma and start-ups will enter this field,and we can expect significant additions to our drug armamentarium soon.
mRNA Vaccines (Current Topics in Microbiology and Immunology #440)
by Dong Yu Benjamin PetschThe formulation and the technological advancements in RNA biology, chemistry, stability, and encapsulated delivery systems that have enabled the development of fully synthetic mRNA vaccines are discussed in this volume. The applications of the mRNA technology is covered, focusing on infectious diseases but also touching on other indications, such as immunotherapies and molecular therapies. Potent and long-lasting immune responses observed in animal models, encouraging data from early human clinical studies, together with the success of two mRNA-based COVID-19 vaccines support the use of mRNA-based vaccination as an attractive alternative to conventional vaccine approaches. Consequently, the development progress of the technology, particularly on production, capabilities, and clinical development is reviewed. Topics on safety, regulatory issues, and possible challenges to the mRNA vaccination approach round off this book. Thanks to their high potency, the prospect for generic, low-cost manufacturing processes, and entirely synthetic nature, the future for mRNA vaccines is highly promising. Importantly, mRNA vaccines have the potential to minimize the time between pathogen identification and vaccine release with a huge impact on public health. As the mRNA-based vaccination technology has been progressing rapidly, the book is intended to be an end-to-end review series, covering everything from basic RNA biology and preclinical studies to the manufacturing strategy, clinical development and regulatory approval. It provides established RNA researchers and developers with updates on the latest advancements in the field and allows for a quick but comprehensive overview of this transformative technology, its application, and future potential.
Mrs. Frisby and the Rats of Nimh: 50th Anniversary Edition (Literature Unit Ser.literature Unit Seriesliterature Units)
by Robert C. O'BrienSome extraordinary rats come to the aid of a mouse family in this Newbery Medal Award–winning classic by notable children&’s author Robert C. O&’Brien.Mrs. Frisby, a widowed mouse with four small children, is faced with a terrible problem. She must move her family to their summer quarters immediately, or face almost certain death. But her youngest son, Timothy, lies ill with pneumonia and must not be moved. Fortunately, she encounters the rats of NIMH, an extraordinary breed of highly intelligent creatures, who come up with a brilliant solution to her dilemma. And Mrs. Frisby in turn renders them a great service. <br><br> <P><P><i>Advisory: Bookshare has learned that this book offers only partial accessibility. We have kept it in the collection because it is useful for some of our members. Benetech is actively working on projects to improve accessibility issues such as these.</i>
Mrs. Jafee Is Daffy! (My Weird School Daze #6)
by Jim Paillot Dan GutmanThe weirdness never stops! <p><p> The new vice principal of Ella Mentry School has some crazy ideas on how to teach kids. A.J. and the gang have to stand on their heads while they do math! They have to take a spelling test underwater! Everybody has to do yoga! Could it possibly get any weirder?