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Molecular Identification of Mosquito Vectors and Their Management
by Tapan Kumar BarikThis book summarizes the recent advancements in identifying the mosquito vectors and discusses various strategies for their control. The book describes various molecular taxonomic methods, including DNA barcoding and single nucleotide polymorphism-based machine learning approach, which are used for the identification of mosquito vectors. It also presents the various mosquito control methods, namely, phytochemicals, Bacillus thuringiensis toxins, nanotechnology, biological control agents, and environmental management strategies. It also highlights the importance of various repellents that are used for protection from different kinds of mosquito vectors. Finally, the book offers a comprehensive yet representative description of challenges associated with mosquito vector-borne diseases. The book is a useful resource for medical entomologists, health workers, and researchers working in mosquito-control and vector-borne diseases.
Molecular Imaging
by Khalid ShahIn recent years, molecular imaging techniques have grown to be invaluable tools for molecular biology research and, to a more modest extent, clinical medicine. In Molecular Imaging: Methods and Protocols, expert researchers explore the latest advances in the field, describing a rich variety of practical procedures and methods for diverging imaging technologies. Chapters are divided into sections that cover the imaging of basic molecular and biochemical events, imaging in pre-clinical settings, and imaging in clinical settings. Composed in the highly successful Methods in Molecular BiologyTM series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls. Comprehensive and ground-breaking, Molecular Imaging: Methods and Protocols is an essential handbook for students, established practitioners, and research fellows alike.
Molecular Imaging for Brain Diseases (Neuromethods #222)
by Daichi SoneThis volume aims provides timely reviews with special focus on the clinical aspects of brain molecular imaging. The chapters reflect the interdisciplinary nature of the field detailing, glutamate receptor imaging, tau and amyloid imaging, glucose metabolism, opioid receptor, dopamine receptor imaging, brain metabolite measurements by 1H-MRS, and analytical methods using artificial intelligence, which have become extremely important in recent years. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.Cutting-edge and comprehensive, Molecular Imaging for Brain Diseases provides methods to navigate this complex field and inspire a deeper appreciation for the brain&’s molecular underpinnings.
Molecular Imaging in Oncology
by Burkhard Riemann Otmar SchoberThe impact of molecular imaging on diagnostics, therapy, and follow-up in oncology is increasing steadily. Many innovative molecular imaging probes have already entered clinical practice, and there is no doubt that the future emphasis will be on multimodality imaging in which morphological, functional, and molecular imaging techniques are combined in a single clinical investigation. This handbook addresses all aspects of molecular imaging in oncology, from basic research to clinical applications. The first section is devoted to technology and probe design, and examines a variety of PET and SPECT tracers as well as multimodality probes. Preclinical studies are then discussed in detail, with particular attention to multimodality imaging. In the third section, diverse clinical applications are presented, and the book closes by looking at future challenges. This handbook will be of value to all who are interested in the revolution in diagnostic oncology that is being brought about by molecular imaging.
Molecular Imaging of Small Animals
by Habib ZaidiThis book examines the fundamental concepts of multimodality small-animal molecular imaging technologies and their numerous applications in biomedical research. Driven primarily by the widespread availability of various small-animal models of human diseases replicating accurately biological and biochemical processes in vivo, this is a relatively new yet rapidly expanding field that has excellent potential to become a powerful tool in biomedical research and drug development. In addition to being a powerful clinical tool, a number of imaging modalities including but not limited to CT, MRI, SPECT and PET are also used in small laboratory animal research to visualize and track certain molecular processes associated with diseases such as cancer, heart disease and neurological disorders in living small animal models of disease. In vivo small-animal imaging is playing a pivotal role in the scientific research paradigm enabling to understand human molecular biology and pathophysiology using, for instance, genetically engineered mice with spontaneous diseases that closely mimic human diseases.
Molecular Imaging of the Brain
by M. M. Kaila Rakhi KailaThis book examines multi-quantum magnetic resonance imaging methods and the diagnostics of brain disorders. It consists of two Parts. The part I is initially devoted towards the basic concepts of the conventional single quantum MRI techniques. It is supplemented by the basic knowledge required to understand multi-quantum MRI. Practical illustrations are included both on recent developments in conventional MRI and the MQ-MRI. This is to illustrate the connection between theoretical concepts and their scope in the clinical applications. The Part II initially sets out the basic details about quadrupole charge distribution present in certain nuclei and their importance about the functions they perform in our brain. Some simplified final mathematical expressions are included to illustrate facts about the basic concepts of the quantum level interactions between magnetic dipole and the electric quadrupole behavior of useful nuclei present in the brain. Selected practical illustrations, from research and clinical practices are included to illustrate the newly emerging ideas and techniques. The reader should note that the two parts of the book are written with no interdependence. One can read them quite independently.
Molecular Imaging with Reporter Genes
by Sanjiv Sam Gambhir Shahriar S. YaghoubiReporter genes have been used for several decades to study regulation of gene expression in vivo. However, it was little more than a decade ago that a new class of reporter genes was developed for imaging molecular events within living subjects. By following the interactions of protein molecules, researchers can resolve the complex chemical pathways that living cells utilise. This book focuses on this group of imaging reporter genes, starting with detailed descriptions of all reporter genes from different imaging modalities, including optical, MRI, and radionuclide-based imaging. Key scientists in the field explain how to enhance reporter gene imaging utility through instrumentation and the various applications of this technology. This is the first comprehensive book on all aspects of reporter gene imaging, detailing what is known in the field and future goals for research. Investigators in biomedical sciences, physicians, and the biotechnology and pharmaceutical industries will benefit from topics covered.
Molecular Immunotoxicology
by Emanuela Corsini Henk Van LoverenThe first comprehensive reference on immunotoxicology using analyses based on molecular effects rather than on animal models. Following an introduction to immune system pathways and toxicity mechanisms from a systemic perspective, the main part of the book surveys individual molecular mechanisms of important immunotoxicants, from PAHs to biopharmaceuticals, and from receptor-mediated toxicity to nanoparticle toxicity. Taken together, the knowledge presented here provides an up-to-date overview of this hot topic that can be directly applied to the prediction and characterization of immunotoxic effects in drugs, chemicals, and environmental contaminants.
Molecular Imprinting
by Karsten HauptMolecularly Imprinted Polymers, by Karsten Haupt, Ana V. Linares, Marc Bompart und Bernadette Tse Sum Bui.- Physical Forms of MIPs, by Andrea Biffis, Gita Dvorakova und Aude Falcimaigne-Cordin.- Micro and Nanofabrication of Molecularly Imprinted Polymers, by Marc Bompart, Karsten Haupt und Cédric Ayela.- Immuno-Like Assays and Biomimetic Microchips, by M. C. Moreno-Bondi, M. E. Benito-Peña, J. L. Urraca und G. Orellana.- Chemosensors Based on Molecularly Imprinted Polymers, by Subramanian Suriyanarayanan, Piotr J. Cywinski, Artur J. Moro, Gerhard J. Mohr und Wlodzimierz Kutner.- Chromatography, Solid-Phase Extraction, and Capillary Electrochromatography with MIPs, by Blanka Tóth und George Horvai.- Microgels and Nanogels with Catalytic Activity, by M. Resmini, K. Flavin und D. Carboni.
Molecular Imprinting of Polymers
by Sergey PiletskyOne of Nature's most important talents is evolutionary development of systems capable of molecular recognition: distinguishing one molecule from another. Molecular recognition is the basis for most biological processes, such as ligandreceptor binding, substrate-enzyme reactions and translation and transcription of the genetic code and is therefore
Molecular Industrial Mycology: Systems and Applications for Filamentous Fungi (Mycology Ser. #8)
by LeongTen articles provide an overview of the recently flowering research into the genetics and molecular biology of fungus species that are economically significant in industry. The contributors, from a variety of disciplines, report on work in such areas as industrial enzymes, antibiotics, toxins, heter
Molecular Interactions: Concepts and Methods
by David A. MichaA modern, comprehensive text and reference describing intermolecular forces, this book begins with coverage of the concepts and methods for simpler systems, then moves on to more advanced subjects for complex systems – emphasizing concepts and methods used in calculations with realistic models and compared with empirical data. Contains applications to many physical systems and worked examples Proceeds from introductory material to advanced modern treatments Has relevance for new materials, biological phenomena, and energy and fuels production
Molecular Interventions for Developing Climate-Smart Crops: A Forage Perspective
by Shahid Ahmed Rajesh Kumar Singhal Saurabh Pandey Subhash ChandThis edited book is collection of information on molecular interventions needed for climate-resilient forage crops. The main focus is to address the gap in the advanced scientific knowledge for the forage species. Agriculture is extremely vulnerable to climate, and even slight change in climatic factors such as temperature causes tremendous losses in yield potential. Forage crops are crucial in global food security and environmental sustainability and face several environmental challenges in field conditions. However, the research on forage crops is far-off compared to agricultural crops and causes a substantial gap in forage demand and productivity. Further, this gap is directly associated with animal health, reproduction, and productivity. Abiotic stresses mainly affect the plant's crucial processes, ultimately reducing the final yield. The problem of abiotic stresses is more frequent in forage crops as they are growing and cultivated in less productive soil and harsh conditions. This book discusses current aspects of crucial physiological, biochemical and molecular processes in forage crops, which are essential for forage crops improvement. The text's major focus is on the advanced technologies and approaches such as seed priming, bio-fortification, breeding, omics, transgenic and bioengineering of metabolic pathways in unique ways, which helps us develop innovative solutions for forage crops. This book covers all the crucial advance technologies, which help mitigate the abiotic stresses in forage crops. We believe that this book will initiate and introduce the readers to state-of-the-art developments and unique in this field of study. This book is of interest to teachers, researchers, climate change scientists, capacity builders, and policymakers. Also, the book serves as additional reading material for undergraduate and graduate students of agriculture, forestry, ecology, soil science, and environmental sciences. National and international agricultural scientists and policymakers will also find this a worthwhile read.
Molecular Interventions in Lifestyle-Related Diseases
by Toshikazu Yoshikawa Lester Packer Midori HiramatsuThe Japanese Ministry of Health, Labor and Welfare, officially recognizing that various risk factors for disease are present in our environment, has proposed the concept of lifestyle-related diseases. These include those diseases that are tied to such lifestyle choices as excessive alcohol consumption, cigarette smoking, exposure to stress, and poo
Molecular Kinetics in Condensed Phases: Theory, Simulation, and Analysis
by Ron Elber Dmitrii E. Makarov Henri OrlandA guide to the theoretical and computational toolkits for the modern study of molecular kinetics in condensed phases Molecular Kinetics in Condensed Phases: Theory, Simulation and Analysis puts the focus on the theory, algorithms, simulations methods and analysis of molecular kinetics in condensed phases. The authors – noted experts on the topic – offer a detailed and thorough description of modern theories and simulation methods to model molecular events. They highlight the rigorous stochastic modelling of molecular processes and the use of mathematical models to reproduce experimental observations, such as rate coefficients, mean first passage times and transition path times. The book’s exploration of simulations examines atomically detailed modelling of molecules in action and the connections of these simulations to theory and experiment. The authors also explore the applications that range from simple intuitive examples of one- and two-dimensional systems to complex solvated macromolecules. This important book: Offers an introduction to the topic that combines theory, simulation and analysis Presents a guide written by authors that are well-known and highly regarded leaders in their fields Contains detailed examples and explanation of how to conduct computer simulations of kinetics. A detailed study of a two-dimensional system and of a solvated peptide are discussed. Discusses modern developments in the field and explains their connection to the more traditional concepts in chemical dynamics Written for students and academic researchers in the fields of chemical kinetics, chemistry, computational statistical mechanics, biophysics and computational biology, Molecular Kinetics in Condensed Phases is the authoritative guide to the theoretical and computational toolkits for the study of molecular kinetics in condensed phases.
Molecular Layer Deposition for Tailored Organic Thin-Film Materials (Optics and Photonics)
by Tetsuzo YoshimuraThis book provides concepts and experimental demonstrations for various types of molecular layer deposition (MLD) and organic multiple quantum dots (organic MQDs), which are typical tailored organic thin-film materials. Possible applications of MLD to optical interconnects, energy conversion systems, molecular targeted drug delivery, and cancer therapy are also proposed. First, the author reviews various types of MLD processes including vapor-phase MLD, liquid-phase MLD, and selective MLD. Next, he introduces organic MQDs, which are typical tailored organic thin-film materials produced by MLD. The author then describes the design of light modulators/optical switches, predicts their performance, and discusses impacts of the organic MQDs on them. He then also discusses impacts of the organic MQDs on optical interconnects within computers and on optical switching systems. Finally, the author presents MLD applications to molecular targeted drug delivery, photodynamic therapy, and laser surgery for cancer therapy. This book is intended for researchers, engineers, and graduate students in optoelectronics, photonics, and any other field where organic thin-film materials can be applied.
Molecular Life Sciences
by Judith Klinman Robert D. Wells Judith S. Bond Bettie Sue Siler MastersThe Encyclopedia examines biological phenomena at the molecular level and their interactions that govern life processes. Covers genes and genomes; protein structure and function; unifying concepts from biology, chemistry, mathematics and physics and more.
Molecular Machines Involved in Peroxisome Biogenesis and Maintenance
by Cecile Brocard Andreas HartigIn eukaryotes, lipid metabolism requires the function of peroxisomes. These multitasking organelles are also part of species-specific pathways such as the glyoxylate cycle in yeast and plants or the synthesis of ether lipid in mammals. Proteins required for the biogenesis of peroxisomes typically assemble in large molecular complexes, which participate in membrane formation, protein transport, peroxisome duplication and - inheritance during cell division. Peroxisomal function is essential for life. Mutations in PEX genes, encoding for biogenesis factors, are often associated with lethal disorders. The association of peroxisomes with other organelles suggests an extensive participation in organellar crosstalk. This book represents a state-of-the-art review in the field of peroxisome research encompassing the cell and molecular biology of peroxisome biogenesis and its diseases, the protein complexes involved in this process and the modern technologies applied to study them. The book is intended for graduate students, researchers and lecturers in biochemistry, molecular and cell biology with a biomedical background.
Molecular Machines and Motors
by Alberto Credi Serena Silvi Margherita VenturiThe cutting-edge advances in this research field are nicely pictured in the chapters of this volume. They come from world's leading laboratories engaged in the development of molecular machines and are authored by some of the most respected scientists in the field. This volume shows, on the one hand, the level of ingenuity and technical capability reached in the construction of artificial nanomachines roughly two decades after their inception. On the other hand, it conveys the excitement about the enormous opportunities as well as the challenges this research area presents, as the interest of researchers is shifting from ensemble to single-molecule measurements and from homogeneous to heterogeneous environments. Indeed, as Feynman said "when we have some control of the arrangement of things on a molecular scale, we will get an enormously greater range of possible properties that substances can have. " Although the answer to the "when" question is not easy to find, there is no doubt that artificial molecular machines and motors will lead to a wide variety of applications which we cannot even envisage today. The Nobel Prize in Chemistry 2016 was awarded jointly to Jean-Pierre Sauvage, Sir J. Fraser Stoddart and Bernard L. Feringa "for the design and synthesis of molecular machines". Both Jean-Pierre Sauvage and Bernard L. Feringa contributed to this volume. The goal of each thematic volume in this series is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field. Review articles for the individual volumes are invited by the volume editors. Readership: research chemists at universities or in industry, graduate students.
Molecular Machines in Biology
by Joachim FrankThe concept of molecular machines in biology has transformed the medical field in a profound way. Many essential processes that occur in the cell, including transcription, translation, protein folding and protein degradation, are all carried out by molecular machines. This volume focuses on important molecular machines whose architecture is known and whose functional principles have been established by tools of biophysical imaging (X-ray crystallography and cryo-electron microscopy) and fluorescence probing (single-molecule FRET). This edited volume includes contributions from prominent scientists and researchers who understand and have explored the structure and functions of these machines. This book is essential for students and professionals in the medical field who want to learn more about molecular machines.
Molecular Magnetochemistry
by Sergey Vulfson PhDInvestigating the relationship between the magnetic properties and structure of molecules, molecular magnetochemistry, is an area of growing interest to scientists in a variety of fields, including physical, organic and inorganic chemistry, molecular physics, and biophysics. For the first time, systematic results on magnetic properties of molecules such as mean magnetic susceptibility, their anisotropies and principal magnetic axes are presented. Molecular Magnetochemistry is a comprehensive and up-to-date view on experimental methods not covered in previous volumes, including the Zeeman effect in vapor phase and magnetic birefringence of diamagnetic systems (Cotton-Mouton Effect). The relationship between magnetic and related electrical phenomena is also described, summing up experimental data on magnetic and electrical anisotropies and components of molecular quadrupole moments.
Molecular Magnets
by Juan Bartolomé Fernando Luis Julio F. FernándezThis book provides an overview of the physical phenomena discovered in magnetic molecular materials over the last 20 years. It is written by leading scientists having made the most important contributions to this active area of research. The main topics of this book are the principles of quantum tunneling and quantum coherence of single-molecule magnets (SMMs), phenomena which go beyond the physics of individual molecules, such as the collective behavior of arrays of SMMs, the physics of one-dimensional single-chain magnets and magnetism of SMMs grafted on substrates. The potential applications of these physical phenomena to classical and quantum information, communication technologies, and the emerging fields of molecular spintronics and magnetic refrigeration are stressed. The book is written for graduate students, researchers and non-experts in this field of research.
Molecular Male Reproductive Medicine: Biology and Clinical Perspectives (Advances in Experimental Medicine and Biology #1469)
by C. Yan Cheng Fei SunThis book bridges the gap of basic research in male reproductive biology and its relationship to clinical studies. Bringing together a group of senior investigators with decades of experience in research and clinical investigation and keen interest in collaboration between the two areas, this book provides a balanced treatment of technical and basic research insights and cutting-edge findings, while introducing new ideas for clinical applications of this research. Section I is devoted to clinical aspects including testis biology, prostate biology, and spermatogenesis by senior investigators of male infertility treatment, particularly non-obstructive azoospermia. Section II presents the latest findings in male reproductive biology from a basic research perspective, as well as covering cutting-edge technology such as scRNA-Seq, scATAC-Seq, DNA chromatic accessibility and organization studies, genetic models, cell biology, molecular biology, and biochemistry on testis biology, and spermatogenesis. This book offers not only a cohesive summary of new findings and concepts in basic and clinical male reproductive research, it analyzes and assembles these concepts into a roadmap for the next decade of translational research, bringing lab discoveries to the bedside.
Molecular Marker Applications for Improving Sugar Content in Sugarcane
by M. Swapna Sangeeta SrivastavaSugarcane, an important source of sugar, plays a substantial role in world economy. As a C4 plant this has very efficient system for carbohydrate metabolism through photosynthesis. Crop improvement efforts have concentrated mainly on improving quality traits, mainly sugar content. This being a complex trait, involves a large number of target genes in the metabolic pathway. The complex polyploid nature of the crop makes it more difficult to pin point the key players in this complex pathway. Despite its importance, little is known about the exact mechanism of sucrose accumulation and its regulation in sugarcane. Many enzymes have been proposed to have a key role in determining the ultimate sucrose content in sugarcane. There are evidences to show that some of these like Sucrose Phosphate Synthase (SPS) and Sucrose Synthase (SuSy) are encoded by multiple genes that show organ specifity in sugarcane. Especially in a crop like sugarcane where the classical techniques are of limited help in elucidating various genetic complexities, molecular techniques can be of help in throwing some light on the grey areas. Molecular marker strategies will be of help in understanding some aspects of sucrose metabolism and its regulation in this crop, thus complementing the ongoing crop improvement programmes.
Molecular Marker Techniques: A Potential Approach of Crop Improvement
by Nitish KumarThis edited book covers the applications of molecular markers in the genetic improvement of crop plants. Recent advances in molecular marker techniques such as the development of high-throughput genotyping platforms, marker-assisted selection, and non-coding RNA-based markers have been discussed. Essential information is provided on functional markers, genotype-by-sequencing, and association mapping methodologies that can facilitate accelerated crop breeding programs for increased yield, high nutritional quality, and tolerance to a variety of abiotic and biotic stresses. This volume presents basic information on molecular marker techniques from marker location up to gene cloning. The book includes a description of technical approaches in genome analysis such as comparison of marker systems, positional cloning, and array techniques. This book is of interest to teachers, researchers, and plant breeders. The book also serves as additional reading material for undergraduate and graduate students of agriculture, horticulture, and forestry.