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Molecular Switches, 2 Volume Set
by Wesley R. Browne Ben L. FeringaThe long-awaited second edition of the successful book covering molecular switches now in two volumes! Providing principles and applications this book brings you everything you need to know about molecular switches - a hot topic in the nanoworld. The major classes of molecular switches including catenanes, rotaxanes, azobenzenes together with polymer and biomolecular switching systems and DNA based switches are covered. Chemists and material scientists interested in one of the most innovative areas of their science will benefit greatly from reading this book. "This book will appeal most to organic chemists, because of the way new structures are introduced through their synthesis, but it will also provide a useful introduction for other scientists, provided they are conversant with molecular structures." (Organic and Biomolecular Chemistry) "... a comprehensive and up-to-date insight ..." (Chemistry & Industry)
Molecular Symmetry and Group Theory: A Programmed Introduction to Chemical Applications
by Alan VincentThis substantially revised and expanded new edition of the bestselling textbook, addresses the difficulties that can arise with the mathematics that underpins the study of symmetry, and acknowledges that group theory can be a complex concept for students to grasp. Written in a clear, concise manner, the author introduces a series of programmes that help students learn at their own pace and enable to them understand the subject fully. Readers are taken through a series of carefully constructed exercises, designed to simplify the mathematics and give them a full understanding of how this relates to the chemistry. This second edition contains a new chapter on the projection operator method. This is used to calculate the form of the normal modes of vibration of a molecule and the normalised wave functions of hybrid orbitals or molecular orbitals. The features of this book include: * A concise, gentle introduction to symmetry and group theory * Takes a programmed learning approach * New material on projection operators, and the calcultaion of normal modes of vibration and normalised wave functions of orbitals This book is suitable for all students of chemistry taking a first course in symmetry and group theory.
Molecular Systematics of Parasitic Helminths
by Urusa Thaenkham Kittipong Chaisiri Abigail Hui En ChanThis book aims to provide fundamental knowledge and information for research in molecular systematics on parasitic helminths (nematode, trematode, cestode). The shreds of evidence of molecular systematics studies will be compiled and discussed in terms of the utilities and pitfalls of the genetic marker used for various purposes, which have been implemented for molecular systematics of parasitic nematodes, cestodes, and trematodes. Moreover, this book will also provide the procedure for research on molecular systematics and DNA taxonomy as the guideline to explore parasitic helminths. Finally, the further perspectives of utilizing genetic markers for molecular studies on parasitic helminths will be addressed in the context of applications from the laboratory to fieldwork such as DNA barcoding and environmental DNA metabarcoding of parasitic helminths. The book will benefit postgraduate students and researchers requiring the detailed knowledge of molecular systematics, as well as researchers desiring a guideline to select genetic markers and analyze DNA sequences to make phylogenetic inferences
Molecular Targets and Therapeutic Interventions Against Neurodegenerative Diseases
by Vaishali Manikrao Patil, Dileep Kumar, and Neeraj MasandThis book comprehensively explores the latest advancements in the understanding, diagnosis, and treatment of neurodegenerative diseases. The chapters provide an in-depth review of current approaches and treatment strategies for Alzheimer's disease, offering insights into the latest developments and breakthroughs. It also reviews the cutting-edge research on potential novel targets for Alzheimer's pharmacotherapy, with a focus on JNK3, GSK3β, and Fyn kinase inhibitors, providing an update on related approaches and their implications. It discusses the potential of ethnomedicines as a promising tool for mitigating Alzheimer's disease, offering insights into traditional remedies and their modern applications. Additional chapters explore the influence of microglia, the neuropharmacological mechanisms associated with SARS-CoV-2, and the molecular intricacies of Parkinson’s disease. The book further covers the evolving role of artificial intelligence and machine learning in the management of neurodegenerative disorders. The chapters also examine the role of nanotechnology in addressing the challenges of diseases like multiple sclerosis. Towards the end, the book examines the role of oxidative damage in neurodegeneration and its management in related disorders. This book is an important source for neuroscientists, neurologists, and students of neuroscience.
Molecular Techniques for Studying Viruses: Practical Notes
by Zubaida Hassan Gulfaraz KhanThis volume provides detailed information on various laboratory techniques and methodologies used for studying viruses at the molecular level. It covers essential topics such as nucleic acid isolation, protein isolation, PCR-based techniques, western blotting, serological assays, immunoprecipitation, small interfering RNA (siRNA), histological methods, bioinformatics and in silico simulations. Each chapter provides a detailed overview of the techniques, their applications, and their significance in virus research. The book is a useful resource as a practical introductory note that could be used for hands-on training of students, both undergraduates and junior postgraduates.
Molecular Techniques in Crop Improvement
by Shri Mohan Jain D. S. BrarThis book provides comprehensive information on the latest tools and techniques of molecular genetics and their applications in crop improvement. It thoroughly discusses advanced techniques used in molecular markers, QTL mapping, marker-assisted breeding, and molecular cytogenetics.
Molecular Technologies for Detection of Chemical and Biological Agents
by Joseph H. Banoub Richard M. CaprioliThis book describes the latest molecular insights needed to understand the chemical and biological (CB) agents and their associated biotechnologies. Its primary focus is to present and discuss molecular technologies such as mass spectrometry, chemical and biological sensors, chromatographic and electrophoretic separation, and comparisons of spectroscopic, immunological and molecular analyses of chemicals used for the detection of chemical and biological agents and to prevent terrorism. This NATO-ASI book also contributes to the critical assessment of existing knowledge on new and important detection technologies. It helps to identify directions for future research and to promote closer working relationships between scientists from different professional fields.
Molecular Technology, Volume 3: Materials Innovation
by Hisashi Yamamoto Takashi KatoEdited by foremost leaders in chemical research together with a number of distinguished international authors, this third volume summarizes the most important and promising recent developments in material science in one book. Interdisciplinary and application-oriented, this ready reference focuses on innovative methods, covering new developments in photofunctional materials, polymer chemistry, surface science and more. Of great interest to chemists as well as material scientists alike.
Molecular Technology, Volume 4: Synthesis Innovation
by Hisashi Yamamoto Takashi KatoEdited by foremost leaders in chemical research together with a number of distinguished international authors, this fourth volume summarizes the most important and promising recent developments in synthesis, polymer chemistry and supramolecular chemisty. Interdisciplinary and application-oriented, this ready reference focuses on innovative methods, covering new developments in catalysis, synthesis, polymers and more. Edited by foremost leaders in chemical research together with a number of distinguished international authors, this fourth volume summarizes the most important and promising recent developments in synthesis, polymer chemistry and supramolecular chemisty. Interdisciplinary and application-oriented, this ready reference focuses on innovative methods, covering new developments in catalysis, synthesis, polymers and more.
Molecular Technology: Life Innovation
by Hisashi Yamamoto Takashi KatoEdited by foremost leaders in chemical research together with a number of distinguished international authors, Volume 2 presents the most important and promising recent chemical developments in life sciences, neatly summarized in one book. Interdisciplinary and application-oriented, this ready reference focuses on methods and processes with a high practical aspect, covering new trends in drug delivery, in-vivo analysis, structure formation and much more.Of great interest to chemists and life scientists in academia and industry.
Molecular Theory of Capillarity (Dover Books on Chemistry)
by J. S. Rowlinson B. WidomHistory of thought on molecular origins of surface phenomena offers a critical and detailed examination and assessment of modern theories, focusing on statistical mechanics and application of results in mean-field approximation to model systems. Emphasis on liquid-gas surface, with a focus on liquid-liquid surfaces in the final chapters. 1989 edition.
Molecular Theory of Fluctuation in Life Phenomena
by Fumio HirataThis book describes molecular processes taking place in living cells, in which &“water&” or &“solvation&” play essential roles. The molecular processes include conformational stability, fluctuation, relaxation, self-organization, molecular recognition, and chemical reactions. In all those processes, so-called solvation free-energy, and its first and second derivatives with respect to the atomic coordinates of biomolecules play key roles. Such derivatives of the free energy may not be calculated by any method of molecular simulation, because the calculation requires an analytical formula of the solvation free energy as a function of the atomic coordinates of a biomolecule. In this book, the theory is applied to analyze phenomena closely related to the conformational and density fluctuation of biomolecular systems, including the entropy and spectroscopy of both biomolecules and solvents. The theory is further developed to give microscopic expressions to the well-regarded phenomenological theories of chemical reactions, including the Michaelis–Menten theory of the enzymatic reaction, and the theory of the electron-transfer reaction by R. Marcus. Also clarified in the book is physical basis of Anfinsen&’s hypothesis concerning the protein folding. This book is beneficial for graduate students and researchers in the field of life science and technology, especially for those studying pharmaceutical design and biomimetic technology such as artificial enzymes.
Molecular Theory of Nematic: An Introduction (SpringerBriefs in Physics)
by Paul van der SchootThis book provides a didactic derivation of the main theories of thermotropic and lyotropic liquid crystals, revealing the common molecular-theoretic framework that underpins both theories. This unified context will help young researchers in coming to grips with the basics of the simplest of liquid crystals, being uniaxial nematic liquid crystals, easing them into the intricacies of more complex forms of such materials irrespective of whether they are thermotropic or lyotropic. The coverage provides a theoretical understanding of the phase behaviour, that is, what drives molecules and particles to spontaneously align themselves, as well as an appreciation of the role of entropy, energy and so on. The focus here is on the main theories for the isotropic-nematic transition, being the Maier-Saupe and the Onsager theories, and how they are derived from a common description, known as (classical) density functional theory (DFT). This book will be a valuable resource for senior undergraduate and graduate students, and experimentalists and engineers who feel intimidated by more formal or rigorous theoretical accounts and textbooks. Exercises at the end of each chapter help the reader to apply the basic concepts also to other types of liquid crystal, in particular the smectic liquid crystal.
Molecular Theory of the Living Cell
by Sungchul JiThe book presents the first comprehensive molecular theory of the living cell ever published since the cell doctrine was formulated in 1838-1839. It introduces into cell biology over thirty key concepts, principles and laws imported from physics, chemistry, computer science, linguistics, semiotics and philosophy. The author formulates physically, chemically and enzymologically realistic molecular mechanisms to account for basic living processes such as ligand-receptor interactions, enzymic catalysis, force-generating mechanisms in molecular motors, chromatin remodelling, and signal transduction. Possible solutions to basic and practical problems facing contemporary biology and biomedical sciences have been suggested, including pharmacotherapeutics and personalized medicine.
Molecular Thermodynamics
by Donald A. Mcquarrie John D. SimonThis text covers the principles of quantum mechanics before engaging those ideas in the subsequent development of thermodynamics. It includes worked examples and chapter-ending problems with solutions.
Molecular Tools for the Detection and Quantification of Toxigenic Cyanobacteria
by Annick Wilmotte Kaarina Sivonen Nico Salmaso Rainer KurmayerA guide to state-of-the-art molecular tools for monitoring and managing the toxigenicity of cyanobacteria Runaway eutrophication and climate change has made the monitoring and management of toxigenic organisms in the world’s bodies of water more urgent than ever. In order to influence public policy regarding the detection and quantification of those organisms, it is incumbent upon scientists to raise the awareness of policy makers concerning the increased occurrence of toxigenic cyanobacteria and the threats they pose. As molecular methods can handle many samples in short time and help identify toxigenic organisms, they are reliable, cost-effective tools available for tracking toxigenic cyanobacteria worldwide. This volume arms scientists with the tools they need to track toxigenicity in surface waters and food supplies and, hopefully, to develop new techniques for managing the spread of toxic cyanobacteria. This handbook offers the first comprehensive treatment of molecular tools for monitoring toxigenic cyanobacteria. Growing out of the findings of the landmark European Cooperation in Science and Technology Cyanobacteria project (CYANOCOST), it provides detailed, practical coverage of the full array of available molecular tools and protocols, from water sampling, nucleic acid extraction, and downstream analysis—including PCR and qPCR based methods—to genotyping (DGGE), diagnostic microarrays, and community characterization using next-gen sequencing techniques. Offers an overview of the latest trends in the field, while providing a foundation for understanding and applying the tools and techniques described Provides detailed coverage of the full range of molecular tools currently available, with expert guidance on the analysis and interpretation of results Includes step-by-step guidance on standard operational procedures, including molecular tests used in environmental monitoring, with individual chapters devoted to each procedure Complements the published Handbook of Cyanobacterial Monitoring and Cyanotoxin Analysis from the CyanoCOST project This handbook is an indispensable working resource for scientists, lab technicians, and water management professionals and an excellent text/reference for graduate students and supervisors who use molecular tools. It will also be of great value to environmental health and protection officials and policy makers.
Molecular Toxicology (Advanced Texts)
by Nick PlantMolecular Toxicology is a concise introduction to the subject, taking the reader through the theoretical principles of toxicology followed by specific examples. In the first section, the concepts behind possible mechanisms of toxicity are described (e.g. the specific enzyme or receptor system) using examples where appropriate. Following this a series of examples are used to show the extension of concept into the real world, in an organ specific manner. The book concludes with a section outlining toxicity assessment methods, where the impact of molecular biology is having a considerable impact, including DNA microarrays, proteomics and bioinformatics.
Molecular Toxicology Protocols (Methods in Molecular Biology #2102)
by Phouthone Keohavong Kamaleshwar P. Singh Weimin GaoThis fully revised book includes new and improved protocols to analyze toxicity at the DNA, RNA, and protein levels using genomic, epigenomic, transcriptomic, and proteomic approaches. Sections of the book address key subjects such as bioinformatics and biostatistics, toxicant-induced lung inflammation and tumors, analysis of protein and gene expression and silencing, gene promoter methylation, detection of chromosomal and genome-wide damage, analysis of DNA-adducts and surrogate gene mutations, detection and characterization of cancer gene mutation, and many other areas of study. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and up-to-date, Molecular Toxicology Protocols, Third Edition will prove to play an important role in generating a better understanding of the field of toxicology and its sub-disciplines.
Molecular Toxicology in Caenorhabditis elegans
by Dayong WangThis book will focus on the molecular basis of oxidative stress induced by toxicants or stresses and various molecular signalling pathways in regulating the toxicity of toxicants or stresses in Caenorhabditis elegans. It will also cover the discussion on the aspects of response signals, G-protein coupled receptors and ion channels, specific molecular signals, and epigenetic signals involved in the regulation of toxicity from toxicants or stresses. The molecular basis for adaptive response for transgenerational toxicity of environmental toxicants or stresses will be further discussed. Nematode Caenorhabditis elegans is a classic model animal with well-described genetic and developmental backgrounds based on the study of life science, and has been further successfully and widely used in both toxicity assessment and toxicological study of various environmental toxicants or stresses. Based on related available data, this book aims at providing a systematic understanding of the knowledge system of molecular toxicology in C. elegans.
Molecular Typing in Bacterial Infections
by Marian L. Mckee Ivano De FilippisMolecular Typing in Bacterial Infections covers common bacterial pathogenic agents, with the most effective methods for their identification and classification in the light of their specific epidemiology. The book will be a valuable resource for molecular typing of infectious diseases agents encountered in both the research and hospital clinical lab settings, as well as culture collections. Each chapter provides an overview of molecular approaches to typing bacterial pathogens. Part I gives a general overview of typing methods used in the traditional microbiology laboratory in comparison to molecular methods of epidemiology. In Part II, the relative strengths and weaknesses of the different methods applicable to the specific agents of infectious diseases are emphasized. Specific emphasis is placed on recent changes and updates in molecular typing.
Molecular Typing in Bacterial Infections, Volume I
by Ivano De FilippisThis updated second edition of Molecular Typing in Bacterial Infections, presented in two volumes, covers both common and neglected bacterial pathogenic agents, highlighting the most effective methods for their identification and classification in the light of their specific epidemiology. New chapters have been included to add new species, as well as another view of how bacterial typing can be used. These books are valuable resources for the molecular typing of infectious disease agents encountered in both research and hospital clinical laboratory settings, as well as in culture collections and in the industry. Each of the 21 chapters provides an overview of specific molecular approaches to efficiently detect and type different bacterial pathogens. The chapters are grouped in five parts, covering respiratory and urogenital pathogens (Volume I), and gastrointestinal and healthcare-associated pathogens, as well as a new group of vector-borne and Biosafety level 3 pathogens including a description of typing methods used in the traditional microbiology laboratory in comparison to molecular methods of epidemiology (Volume II). Comprehensive and updated, Molecular Typing in Bacterial Infections provides state-of-the-art methods for accurate diagnosis and for the correct classification of different types which will prove to be critical in unravelling the transmission routes of human pathogens.
Molecular Typing in Bacterial Infections, Volume II
by Ivano De FilippisThis updated second edition of Molecular Typing in Bacterial Infections, presented in two volumes, covers both common and neglected bacterial pathogenic agents, highlighting the most effective methods for their identification and classification in the light of their specific epidemiology. New chapters have been included to add new species, as well as another view of how bacterial typing can be used. These books are valuable resources for the molecular typing of infectious disease agents encountered in both research and hospital clinical laboratory settings, as well as in culture collections and in the industry. Each of the 21 chapters provides an overview of specific molecular approaches to efficiently detect and type different bacterial pathogens. The chapters are grouped in five parts, covering respiratory and urogenital pathogens (Volume I), and gastrointestinal and healthcare-associated pathogens, as well as a new group of vector-borne and Biosafety level 3 pathogens including a description of typing methods used in the traditional microbiology laboratory in comparison to molecular methods of epidemiology (Volume II). Comprehensive and updated, Molecular Typing in Bacterial Infections provides state-of-the-art methods for accurate diagnosis and for the correct classification of different types which will prove to be critical in unravelling the transmission routes of human pathogens.
Molecular Vaccines
by Matthias GieseThis book gives a comprehensive overview to all aspects of global molecular vaccine research. It introduces concepts of vaccine immunology and molecular vaccine development for viral, bacterial, parasitic and fungal infections. Furthermore, the broad field of research and development in molecular cancer vaccines is discussed in detail. This book is a must have for scientists and clinicians interested in new developments in molecular vaccine research and application in infections and cancer.
Molecular Vibrations: The Theory of Infrared and Raman Vibrational Spectra (Dover Books on Chemistry)
by E. Bright Wilson Jr. J. C. Decius Paul C. CrossBecause of its connection with laser technology, the theory of infrared and Raman vibrational spectra is even more important now than when this book was first published. As the pioneering text in the field and as the text still preferred today, Molecular Vibrations is the undeniable choice of anyone teaching or studying molecular spectroscopy at the graduate level. It is the only book of its kind in the area written by well-known scientists, and besides its value as a pedagogical classic, it is an essential reference for anyone engaged in research. The genius of the book is its rigorous, elegant treatment of the mathematics involved in detailed vibrational analyses of polyatomic molecules. The reader is led carefully and gradually through the main features of the theory and its methods: starting from a valuable introduction to the theory of molecular vibrations and the application of wave mechanics to this subject; leading into the mathematical methods devised by Professor Wilson and his students for handling the mathematical problems and for making use of symmetry and group theory; proceeding through vibrational selection rules and intensities, potential functions and methods of solving the secular determinant; and concluding with a sample vibrational analysis of the molecule of benzene. Sixteen appendices, comprising nearly one hundred pages, offer much extremely useful information that is more clearly understood outside the body of the text. Well-known for their distinguished contributions to the field, the authors -- in addition to Professor Wilson of Harvard University -- are J. C. Decius of Oregon State University and Paul C. Cross, late President of Mellon Institute. Younger students interested in the field of molecular spectroscopy will especially welcome this inexpensive reprint edition of an exceptional book. "An authoritative and complete presentation written on a very high level." -- G. Herzberg, Science"The easiest and quickest route to acquiring skill in handling the mathematics of molecular vibrations." -- Nature
Molecular Virology
by Dietrich Falke Hermann Schätzl Susanne Modrow Uwe TruyenThe book gives a comprehensive overview on the knowledge of virus infection relevant for humans and animals. For each virus family the molecular details of the virus particle and the viral replication cycle are described. In the case of virus types with relevance for human and/or animal health the data on molecular biology, genetics and virus-cell interaction are combined with those concerning, pathogenesis, epidemiology, clinics, prevention and therapy.