- Table View
- List View
Molecular Virology: Methods and Protocols (Methods in Molecular Biology #2940)
by Chunfu ZhengThis detailed book presents classical and cutting-edge techniques in molecular virology research. The volume begins with guidelines for investigating viral structure, proliferation processes, and virulence factors, followed by various approaches to identify key elements and molecular signaling pathways in virus-infected host cells that regulate virus-host interactions. Additional chapters explore methods for studying autophagy, post-translational modifications of virus and host proteins, epigenetic factors in anti-viral immune responses, and viral epidemiology. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Molecular Virology: Methods and Protocols serves as an ideal guide to this vitally important area of study.
Molecular World: Making Modern Chemistry
by Catherine M. JacksonA compelling and innovative account that reshapes our view of nineteenth-century chemistry, explaining a critical period in chemistry&’s quest to understand and manipulate organic nature.According to existing histories, theory drove chemistry&’s remarkable nineteenth-century development. In Molecular World, Catherine M. Jackson shows instead how novel experimental approaches combined with what she calls &“laboratory reasoning&” enabled chemists to bridge wet chemistry and abstract concepts and, in so doing, create the molecular world. Jackson introduces a series of practice-based breakthroughs that include chemistry&’s move into lampworked glassware, the field&’s turn to synthesis and subsequent struggles to characterize and differentiate the products of synthesis, and the gradual development of institutional chemical laboratories, an advance accelerated by synthesis and the dangers it introduced.Jackson&’s historical reassessment emerges from the investigation of alkaloids by German chemists Justus Liebig, August Wilhelm Hofmann, and Albert Ladenburg. Stymied in his own research, Liebig steered his student Hofmann into pioneering synthesis as a new investigative method. Hofmann&’s practice-based laboratory reasoning produced a major theoretical advance, but he failed to make alkaloids. That landmark fell to Ladenburg, who turned to cutting-edge theory only after his successful synthesis.In telling the story of these scientists and their peers, Jackson reveals organic synthesis as the ground chemists stood upon to forge a new relationship between experiment and theory—with far-reaching consequences for chemistry as a discipline.
Molecular and Biochemical Toxicology
by Ernest Hodgson Robert C. SmartAn essential resource for graduate students, academic and industrial toxicologists, and environmental health scientists and professionalsOver the course of thirty years and three editions, Introduction to Biochemical Toxicology has been an important source for coverage of the ongoing quest to define the biochemical, cellular, and molecular events induced by toxicants at the cellular and organismic levels. Now, as the principles and methods of molecular and cellular biology as well as genomic sciences play an ever increasing role in mechanistic toxicology, significant changes have been made to the book, resulting in this important new edition-now titled Molecular and Biochemical Toxicology, Fourth Edition.Much more than an introductory text, this crucial new edition has been completely revised to provide timely and thorough coverage of the underlying biochemical, molecular, and cellular mechanisms through which toxicants produce their adverse effects. Toxicological issues are covered from the molecule to the cell to the organ level. Complex methods used in toxicology are also described in a straightforward, easy-to-understand style. Additional features of this new edition include:New chapters that explore the interface between toxicology and genomic sciences, including: bioinformatics, proteomics, metabolomics, and toxicogenomicsIncreased emphasis on structure, mechanism, and regulation of xenobiotic metabolizing enzymes, toxicogenetics, and xenobiotic transportersAdditional new chapters on: molecular epidemiology and genetic susceptibility, DNA damage and mutagenesis, DNA repair, mechanisms of cell death, mitochondrial dysfunction, metals, reproductive toxicology, developmental toxicology, and reactive oxygen/metabolites and toxicityMolecular and Biochemical Toxicology, Fourth Edition guides graduate students, toxicologists, and environmental health professionals through the principles of molecular and biochemical toxicology and the complex mechanisms of toxicity. Whether it's used in the classroom or in industry, research, or academia, this book is essential for anyone interested in understanding the molecular mechanisms through which toxicants produce adverse effects.
Molecular and Biochemical Toxicology
by Ernest Hodgson Robert C. SmartWritten as an advanced text for toxicology students, this book is much more than an introduction and provides in-depth information describing the underlying mechanisms through which toxicants produce their adverse responses.• Links traditional toxicology to modern molecular techniques, important for teaching to graduate courses and professional studies• Uses a didactic approach with basic biological or theoretical background for the methodology presented• Brings together and comprehensively covers a range of dynamic aspects in biochemical and molecular toxicology• Guides student and professional toxicologists in comprehending a broad range of issues, compiled and authored by a diverse group of experts• “A good introductory textbook covering the biochemical toxicology of organic substances and the relevant methodology in some detail.... It offers good value for money and can be recommended as a textbook for appropriate courses” – BTS Newsletter review of the 4th edition
Molecular and Biotechnological Tools for Plant Disease Management (Interdisciplinary Biotechnological Advances)
by Jayanta Kumar Patra Jen-Tsung Chen Masudulla Khan Aiman ParveenThis book aims to present the latest advances in the application of plant biotechnology and molecular biology in disease management. Among these, molecular techniques can be used to accelerate the detection and identification of pests and pathogens in plants. Also, the identification of resistance genes, characterization of desired resistance genes, and transfer of resistance gene(s) into plants have been performed by applying molecular techniques. The book will collect chapters exploring emerging areas of plant biotechnology including RNAi technology, genetic engineering, GWAS, CRISPR, and nanobiotechnology, and their applications in plant disease management and provides the latest concepts and advances in the field of plant pathology, including detection, identification, characterization, classification and diagnosis, host resistance, disease forecasting, management of plant pests and pathogens, and plant biotechnological approaches. This book offers a valuable reference for educators, students, and researchers in all disciplines of the agricultural sciences, life sciences, and biotechnology at universities, research institutions, and biotechnology companies.
Molecular and Cell Biology For Dummies
by Rene Fester KratzYour hands-on study guide to the inner world of the cellNeed to get a handle on molecular and cell biology? This easy-to-understand guide explains the structure and function of the cell and how recombinant DNA technology is changing the face of science and medicine. You discover how fundamental principles and concepts relate to everyday life. Plus, you get plenty of study tips to improve your grades and score higher on exams! Explore the world of the cell - take a tour inside the structure and function of cells and see how viruses attack and destroy them Understand the stuff of life (molecules) - get up to speed on the structure of atoms, types of bonds, carbohydrates, proteins, DNA, RNA, and lipids Watch as cells function and reproduce - see how cells communicate, obtain matter and energy, and copy themselves for growth, repair, and reproduction Make sense of genetics - learn how parental cells organize their DNA during sexual reproduction and how scientists can predict inheritance patterns Decode a cell's underlying programming - examine how DNA is read by cells, how it determines the traits of organisms, and how it's regulated by the cell Harness the power of DNA - discover how scientists use molecular biology to explore genomes and solve current world problemsOpen the book and find: Easy-to-follow explanations of key topics The life of a cell - what it needs to survive and reproduce Why molecules are so vital to cells Rules that govern cell behavior Laws of thermodynamics and cellular work The principles of Mendelian genetics Useful Web sites Important events in the development of DNA technology Ten great ways to improve your biology grade
Molecular and Cell Biology Methods for Fungi
by Amir SharonWith the development of fungal transformation systems and the deciphering of an increasing number of fungal genomes, this diverse clade of heterotrophic eukaryotic organisms has proven to be ideal for molecular work and highly serviceable as model systems to study basic processes with results that are applicable to many organisms, including humans. In Molecular and Cell Biology Methods for Fungi, experts in the field provide an up-to-date set of practical protocols covering a range of frequently used methods used to study molecular and cellular aspects of fungal biology. The included classical protocols such as transformation systems and traditional protein analysis methods, which have been widely used for many years, alongside the most advanced techniques such as genome amplification, whole genome knockout methods, and sophisticated in vivo imaging techniques will prove to be easily adaptable and useful in a wide range of species. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Comprehensive and up-to-date, Molecular and Cell Biology Methods for Fungi seeks to provide cutting-edge techniques in order to aid both experienced fungal research laboratories as well as those that are interested in using fungi as hosts to study their favorite genes.
Molecular and Cell Biology of Cancer: When Cells Break the Rules and Hijack Their Own Planet (Learning Materials in Biosciences)
by Rita Fior Rita ZilhãoThis textbook takes you on a journey to the basic concepts of cancer biology. It combines developmental, evolutionary and cell biology perspectives, to then wrap-up with an integrated clinical approach.The book starts with an introductory chapter, looking at cancer in a nut shell. The subsequent chapters are detailed and the idea of cancer as a mass of somatic cells undergoing a micro-evolutionary Darwinian process is explored. Further, the main Hanahan and Weinberg “Hallmarks of Cancer” are revisited. In most chapters, the fundamental experiments that led to key concepts, connecting basic biology and biomedicine are highlighted. In the book’s closing section all of these concepts are integrated in clinical studies, where molecular diagnosis as well as the various classical and modern therapeutic strategies are addressed. The book is written in an easy-to-read language, like a one-on-one conversation between the writer and the reader, without compromising the scientific accuracy. Therefore, this book is suited not only for advanced undergraduates and master students but also for patients or curious lay people looking for a further understanding of this shattering disease
Molecular and Cell Biology of Pancreas Development, Function and Regeneration (Advances in Anatomy, Embryology and Cell Biology #239)
by Maria L. GolsonThis book reviews recent advances in pancreatic endocrine and exocrine tissue development, function and regeneration. It provides a comprehensive overview on different aspects of beta-cell biology, including heterogeneity of function and gene expression and function, epigenetics, RNA and protein expression contributions to beta-cell specification and cell-fate maintenance. Furthermore, it covers recent progress in differentiating functional islets in vivo, environmental impacts on beta-cell development and function, and communications between various islet endocrine cells and how they contribute to the regulation of blood glucose homeostasis.The book provides a comprehensive resource for understanding the various compartments of the pancreas and is aimed at pancreas, beta-cell biology, and diabetes researchers.
Molecular and Cellular Biology of Phagocytosis (Advances in Experimental Medicine and Biology #1246)
by Maurice B. HallettPhagocytosis is the engulfment of particulate matter by cells. It is a fundamental (and probably “primitive”) cell biological process which is important in single celled organisms such as amoeba; multicellular animals including coelenterates; and in higher animals. In humans and other mammals, specialised immune cells (phagocytes) utilise phagocytosis in their crucial role of engulfing and destroying infecting microbes. Yet, surprisingly, the biophysics and biochemistry underlying the process has only become clear recently with the advent of genetic manipulation and advances in single cell imaging. In this volume, the aim is to bring together recent fundamental advances that give a clear picture of the underlying mechanism involved in phagocytosis. Not only is this an important topic in its own right, but a full understanding of the process will have a potential impact on human medicine, since as antibiotics become less effective in fight infection, researchers are looking at alternative approaches, including enhancing the “natural” immunity brought about by immune phagocytes.The aim is to provide a comprehensive volume on the topic, with separate chapters on identified recent advances, each written by the major contributors in each area. In addition, the volume will attempt to give a wider overview than is often the case in single author reviews, with an emphasis here on the cell biological understanding of phagocytosis using biophysical approaches alongside the biochemical and imaging approaches.
Molecular and Cellular Biology of Platelet Formation
by Harald Schulze Joseph ItalianoThis book gives a comprehensive insight into platelet biogenesis, platelet signal transduction, involvement of platelets in disease, the use of diverse animal models for platelet research and future perspectives in regard to platelet production and gene therapy. Being written by international experts, the book is a concise state-of-the art work in the field of platelet biogenesis, biology and research. It represents an indispensable tool for research scientists in biomedicine, vascular biology, hematopoiesis and hemostasis and specifically for scientists in platelet research, as well as for clinicians in the field of hematology and transfusion medicine.
Molecular and Cellular Biology of Viruses
by Phoebe LostrohViruses interact with host cells in ways that uniquely reveal a great deal about general aspects of molecular and cellular structure and function. Molecular and Cellular Biology of Viruses leads students on an exploration of viruses by supporting engaging and interactive learning. All the major classes of viruses are covered, with separate chapters for their replication and expression strategies, and chapters for mechanisms such as attachment that are independent of the virus genome type. Specific cases drawn from primary literature foster student engagement. End-of-chapter questions focus on analysis and interpretation with answers being given at the back of the book. Examples come from the most-studied and medically important viruses such as HIV, influenza, and poliovirus. Plant viruses and bacteriophages are also included. There are chapters on the overall effect of viral infection on the host cell. Coverage of the immune system is focused on the interplay between host defenses and viruses, with a separate chapter on medical applications such as anti-viral drugs and vaccine development. The final chapter is on virus diversity and evolution, incorporating contemporary insights from metagenomic research. Key selling feature: Readable but rigorous coverage of the molecular and cellular biology of viruses Molecular mechanisms of all major groups, including plant viruses and bacteriophages, illustrated by example Host-pathogen interactions at the cellular and molecular level emphasized throughout Medical implications and consequences included Quality illustrations available to instructors Extensive questions and answers for each chapter
Molecular and Cellular Biology of Viruses
by Phoebe LostrohThis fully revised second edition of Molecular and Cellular Biology of Viruses leads students on an exploration of viruses by supporting engaging and interactive learning. All the major classes of viruses are covered, with separate chapters for their replication and expression strategies, and chapters for mechanisms such as attachment that are independent of the virus genome type. Specific cases drawn from primary literature foster student engagement. End-of-chapter questions focus on analysis and interpretation with answers being given at the back of the book. Examples come from the most-studied and medically important viruses such as SARS-CoV-2, HIV, and influenza. Plant viruses and bacteriophages are also included. There are chapters on the overall effect of viral infection on the host cell. Coverage of the immune system is focused on the interplay between host defenses and viruses, with a separate chapter on medical applications such as antiviral drugs and vaccine development. The final chapter is on virus diversity and evolution, incorporating contemporary insights from metagenomic research. The second edition has updated suggestions for primary literature to discuss along with each chapter. New to this second edition, a supplementary chapter, freely available for download, looks at how virology intersects with public health, and uses the COVID-19 pandemic as a notable example.Key Features Readable but rigorous coverage of the molecular and cellular biology of viruses Molecular mechanisms of all major groups, including plant viruses and bacteriophages, illustrated by example Host-pathogen interactions at the cellular and molecular level emphasized throughout Medical implications and consequences included Quality illustrations available to instructors New to this second edition, interactive quiz questions hosted online
Molecular and Cellular Biophysics
by Meyer B. JacksonMolecular and Cellular Biophysics provides advanced undergraduate and graduate students with a foundation in the basic concepts of biophysics. Students who have taken physical chemistry and calculus courses will find this book an accessible and valuable aid in learning how these concepts can be used in biological research. The text provides a rigorous treatment of the fundamental theories in biophysics and illustrates their application with examples. Conformational transitions of proteins are studied first using thermodynamics, and subsequently with kinetics. Allosteric theory is developed as the synthesis of conformational transitions and association reactions. Basic ideas of thermodynamics and kinetics are applied to topics such as protein folding, enzyme catalysis and ion channel permeation. These concepts are then used as the building blocks in a treatment of membrane excitability. Through these examples, students will gain an understanding of the general importance and broad applicability of biophysical principles to biological problems.
Molecular and Cellular Biophysics (Pure and Applied Physics)
by Jack A. TuszynskiFrom quantum theory to statistical mechanics, the methodologies of physics are often used to explain some of life's most complex biological problems. Exploring this challenging yet fascinating area of study, Molecular and Cellular Biophysics covers both molecular and cellular structures as well as the biophysical processes that occur in these structures. Designed for advanced undergraduate and beginning graduate students in biophysics courses, this textbook features a quantitative approach that avoids being too abstract in its presentation.Logically organized from small-scale (molecular) to large-scale (cellular) systems, the text first defines life, discussing the scientific controversies between mechanists and vitalists, the characteristics of living things, and the evolution of life. It then delves into molecular structures, including nucleic acids, DNA, RNA, interatomic interactions, and hydrogen bonds. After looking at these smaller systems, the author probes the larger cellular structures. He examines the cytoplasm, the cytoskeleton, chromosomes, mitochondria, motor proteins, and more. The book concludes with discussions on biophysical processes, including oxidative phosphorylation, diffusion, bioenergetics, conformational transitions in proteins, vesicle transport, subcellular structure formation, and cell division.
Molecular and Cellular Enzymology
by Jeannine Yon-Kahn G. HervéMolecular and Cellular Enzymology addresses not only experienced enzymologists but also students, teachers and academic and industrial researchers who are confronted with enzymological problems during their fundamental or applied research. In this field there is an urgent need for training in order to meet the requirements of both research and industrial endeavours. This book consists of several levels. Practical aspects and elementary explanations are given for the benefit of non-specialists' and students' understanding. In order to facilitate the task of students, two typographies have been adopted. The main text corresponds to basic knowledge, whereas text in a smaller font provides more specialised information. Specialists will also find topics more deeply expounded with the principal bibliographic references cited. The bibliography, however, is not exhaustive; the choice includes general books and review articles as well as some specialised articles. In this book, for the first time, the different molecular and cellular aspects of enzymology are presented together. Until now, there has been no book available in which these different aspects are treated in the same volume. In addition, besides the theoretical developments, this book provides a wealth of practical information for experimentalists.
Molecular and Cellular MR Imaging
by Jeff W. M. Bulte Michel M. J. ModoThe ability of molecular and cellular imaging to track the survival, migration, and differentiation of cells in vivo as well as monitor particular gene expression in living subjects is rapidly moving from the research laboratory into daily clinical settings. The interdisciplinary nature of the field mandates a constant dialogue among molecular and
Molecular and Cellular Mechanisms of Toxicity (Routledge Revivals)
by Lewis L. Smith Francesco De MatteisFirst Published in 1995: Written by specialists in their fields, this book contains short reviews intended to highlight points of growing interest in mechanistic toxicology. The first section considers selected aspects of molecular mechanisms, including selectivity of toxic agents and repair processes in the nervous system, toxicity of oxygen, fibers and aflatoxins. The second section discusses the interactions of carcinogens with DNA, and other targets, and their relevance to both molecular dosimetry of exposure and development of cancer. The final part is concerned with cellular and genetic aspects and includes coverage of some of the most recent and rapidly developing problems in toxicology.
Molecular and Cellular Mechanobiology
by Shu Chien Adam J. Engler Peter Yingxiao WangThis book will cover the cutting-edge developments in molecular and cellular mechanobiology to date. Readers will have a clear understanding of mechanobiology at the molecular and cellular levels, encompassing the mechanosensors, transducers, and transcription. An integrative approach across different scales from molecular sensing to mechanotransduction and gene modulation for physiological regulation of cellular functions will be explored, as well as applications to pathophysiological states in disease. A comprehensive understanding of the roles of physicochemical microenvironment and intracellular responses in determining cellular function in health and disease will also be discussed.
Molecular and Cellular Methods in Developmental Toxicology (Methods in Life Sciences - Toxicology Section)
by George P. DastonThis new manual provides a convenient source of experimental procedures, including the most modern and frequently used molecular and cellular techniques. Experimental protocols have been carefully selected by developmental toxicologists for developmental toxicologists. The most important new trends, such as evaluation of the safety of therapeutic antisense oligonucleotides, studies of the role of cell death in abnormal development, and the identification of sparingly expressed developmental control genes are featured. This is the perfect manual for scientists trained in classical developmental toxicology who want to add molecular and cellular methods to their research.
Molecular and Cellular Physiology of Neurons, Second Edition
by Gordon L. FainGordon Fain's Molecular and Cellular Physiology of Neurons, Second Edition is intended for anyone who seeks to understand nerve cell function: undergraduate and graduate students in neuroscience, students of bioengineering and cognitive science, and practicing neuroscientists who want to deepen their knowledge of recent discoveries.
Molecular and Cellular Therapeutics
by David Whitehouse Ralph RapleyMolecular and Cellular Therapeutics aims to bring together key developments in the areas of molecular diagnostics, therapeutics and drug discovery. The book covers topics including diagnostics, therapeutics, model systems, clinical trials and drug discovery. The developing approaches to molecular and cellular therapies, diagnostics and drug discovery are presented in the context of the pathologies they are devised to treat.
Molecular and Colloidal Electro-optics
by Stoyl P. Stoylov Maria V. StoimenovaMolecular and Colloidal Electro-Optics presents cohesive coverage from internationally recognized experts on new approaches and developments in both theoretical and experimental areas of electro-optic science. It comprises a well-integrated yet multi-disciplinary treatment of fundamental principles, strategies, and applications of electro-op
Molecular and Computational Modeling of Cardiac Function (Handbook of Modern Biophysics #7)
by Thomas JueIn Molecular and Computational Modeling of Cardiac Function, a group of prominent professors and researchers explain the fundamental concepts of molecular modeling and illustrate the biomedical applications. The book covers the following topics: Principles of atomistic modeling and simulation of biomolecular systems. Using atomistic modeling to predict the cardiotoxicity of an arrhythmia drug molecule. Bifurcation phenomena in cardiac system as control design of automaticity and arrhythmia. Modeling the role of myoglobin as a fatty acid transporter. Population-based computational approaches to investigate cardiac arrhythmia.
Molecular and Functional Models in Neuropsychiatry
by Jim J. HaganThe development of more effective treatments for neuropsychiatric disorders requires scientific progress on a broad front. Animal models have a vital role to play in advancing the field. When deployed in conjunction with detailed study of these diseases in man they bring the power to make controlled experimental interventions which allow the functional consequences of genetic variations and polymorphisms to be understood in terms of their cellular, systems and behavioural effects. Further, they provide a means by which complex cognitive and behavioural phenomena may be dissected and understood. Finally, they provide a bridge to understanding the effects of drugs on the functioning of the central nervous system, thereby improving our understanding of the actions of those drugs in man.