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Molecular and Physiological Mechanisms of Muscle Contraction
by Jean Emile MorelThoroughly researched using experimentation and re-examination of all previously published evidence, Molecular and Physiological Mechanisms of Muscle Contraction is a carefully crafted treatise and revision of previous conceptions of muscle contraction. It presents detailed descriptions of new, previously unpublished data and hybrids recent finding
Molecular and Quantitative Animal Genetics
by Hasan KhatibAnimal genetics is a central topic in upper-level animal science programs. Filling a void in existing literature on animal science, Animal Genetics introduces genetic principles and presents their application in production and companion animals. The book details population and quantitative genetics, epigenetics, biotechnology, and breeding among other topics. Useful in upper-level studies, Animal Genetics is an irreplaceable educational resource.
Molecular and Supramolecular Chemistry of Natural Products and Their Model Compounds
by Jurgen-Hinrich Fuhrhop Claus EndischAn assessment of the known properties of natural products and their model compounds to determine their usefulness in biological and medical experimentation, as well as in synkinetics - the reversible synthesis of noncovalent compounds. It explores new techniques such as cryoelectron and scanning force microscopy and solid-state NMR spectroscopy of
Molecular and Supramolecular Information Processing
by Evgeny KatzEdited by a renowned and much cited chemist, this book covers the whole span of molecular computers that are based on non-biological systems. The contributions by all the major scientists in the field provide an excellent overview of the latest developments in this rapidly expanding area. A must-have for all researchers working on this very hot topic. Perfectly complements Biomolecular Information Processing, also by Prof. Katz, and available as a two-volume set.
Molecular and Therapeutic actions of Thymoquinone: Actions Of Thymoquinone
by Hina YounusThroughout history black seeds, Nigella sativa seeds, have been highly revered for its medicinal properties. Thymoquinone (TQ), an active principle component of the volatile oil of black cumin seeds, is an emerging natural compound with a wide range of medical applications, and has several beneficial pharmacological actions i.e anti-oxidant, anti-diabetic, anti-inflammatory, anti-microbial, anti-tumor, anti-mutagenic, anti-epileptic, hepatoprotective, neuroprotective, and nephroprotective. As such, it is important to move TQ from the bench to bedside. This book illustrates the therapeutic importance of TQ, offering a detailed account of some of its molecular and therapeutic properties, and discussing in depth its anti-diabetic, anti-cancer, anti-oxidant, anti-inflammatory, anti-microbial, anti-epileptic and hepatoprotective actions. Lastly, the book examines the future prospects of TQ research and its use as a pharmaceutical.
Molecular and Translational Vascular Medicine
by Monte S. Willis Jonathon W. HomeisterMolecular and Translational Vascular Medicine will serve as a state-of-the-art resource for physicians and translational medical researchers alike who are interested in the rapidly evolving field of vascular medicine. The text provides new insight into the basic mechanisms of classic vascular pathophysiologic processes like angiogenesis, atherosclerosis, thrombosis, and vasculitis. Furthermore, it covers new areas of investigation including the role of the ubiquitin proteasome system in vascular disease, endothelial progenitor cells for disease treatment, and the genetic basis of thoracic aortic aneurysms. Lastly, this volume includes sections on the newly emerging field of therapeutic angiogenesis, and the developing technology of nanoparticle-based imaging and therapeutic treatment of the diseased vasculature. All chapters are written by established experts in their fields, including pathologists, cardiovascular surgeons, and internists as well as translational biomedical researchers in a wide range of disciplines. While comprehensive, the material is presented in a manner that simplifies the complex pathophysiologic mechanisms that underlie common vascular diseases. Molecular and Translational Vascular Medicine will be of great value to a broad audience including internists, cardiovascular and vascular surgeons, pathologists, residents and fellows, as well as translational biomedical researchers.
Molecular mechanisms and physiology of disease
by Nilanjana Maulik Tom KaragiannisIn a simplified form, epigenetics refers to heritable changes in phenotype that are not due to changes in the underlying DNA sequence. In this book, epigenetic mechanisms of regulation and dysregulation in health and disease are explored in great depth. Detailed chapters on epigenetic processes including DNA methylation and chromatin post-translational modifications including potential interventions with DNA methyltransferase inhibitors and histone deacetylase inhibitors are explored in initial chapters. These provide a detailed overview and important background to the entire field. The book is then focussed on epigenetic mechanisms involved in various diseases including anti-inflammatory and autoimmune conditions. Important accounts relating to the effects of epigenetics in metabolic syndrome, cardiovascular disease and asthma are the focus of subsequent chapters. The role of epigenetic dysregulation in malignancy is a current topic of interest and represents an intense field of research. A large component of this book is dedicated to the analysis of aberrant epigenetic processes in carcinogenesis and cancer progression. Further, chapters are focused on emerging cancer prevention using nutritional components and anti-cancer therapies particularly with histone deacetylase inhibitors, which have already been approved for the treatment of cutaneous T-cell lymphoma. The emerging role of nanoparticle preparations, especially in the context of delivering potential epigenetic therapies to target cells in various diseases, is also explored in this book. Overall, this book encompasses a wide range of topics related to epigenetic mechanisms in health and disease and would appeal to anyone with an interest in epigenetics, chromatin biology and emerging epigenetic interventions and therapies.
Molecular, Cellular, and Tissue Engineering (The Biomedical Engineering Handbook, Fourth Edition)
by Joseph D. Bronzino Donald R. PetersonKnown as the bible of biomedical engineering, The Biomedical Engineering Handbook, Fourth Edition, sets the standard against which all other references of this nature are measured. As such, it has served as a major resource for both skilled professionals and novices to biomedical engineering.Molecular, Cellular, and Tissue Engineering, the fourth volume of the handbook, presents material from respected scientists with diverse backgrounds in molecular biology, transport phenomena, physiological modeling, tissue engineering, stem cells, drug delivery systems, artificial organs, and personalized medicine.More than three dozen specific topics are examined, including DNA vaccines, biomimetic systems, cardiovascular dynamics, biomaterial scaffolds, cell mechanobiology, synthetic biomaterials, pluripotent stem cells, hematopoietic stem cells, mesenchymal stem cells, nanobiomaterials for tissue engineering, biomedical imaging of engineered tissues, gene therapy, noninvasive targeted protein and peptide drug delivery, cardiac valve prostheses, blood substitutes, artificial skin, molecular diagnostics in personalized medicine, and bioethics.
Molecular- and Nano-Tubes
by Oliver Hayden Kornelius NielschMolecular- and Nano-Tubes summarizes recent advancements in the synthesis, fabrication and applications of tubular structures. An interdisciplinary overview of innovative science focused on tubular structures is provided. The reader is offered an overview of the different fields that molecular and nano tubes appear in, in order to learn the fundamental basics as well as the applications of these materials. This book also: Shows how nanotechnology creates novel materials by crossing the barriers between biology and material science, electronics and optics, medicine and moreDemonstrates that tubes are a fundamental element in nature and used in disparate applications such as ion channels and carbon nanotubes Molecular- and Nano-Tubes is an ideal volume for researchers and engineers working in materials science and nanotechnology.
Molecularizing Biology and Medicine: New Practices and Alliances, 1920s to 1970s (Routledge Studies in the History of Science, Technology and Medicine)
by Harmke Kamminga Soraya de ChadarevianThe contributors present a coherent set of case studies of practices, technologies and strategies aimed at the isolation, investigation, manipulation, production, and uses of molecules including vitamins, hormones, blood products, antibiotics, and vaccines. These case studies examine how processes of molecularization were set in motion in the inter-war period, how they were used as a resource in the biomedical 'mobilization' of World War II, and how new alliances and strategies created as part of the war effort played a central role in the reorganisation of biomedicine in the post-war period.
Molecularly Imprinted Materials: Science and Technology
by Mingdi Yan Olof RamströmWritten by pioneering experts in the field, this book offers a wide range of approaches for molecular imprinting, experimental protocols that exemplify specific techniques, and a detailed survey on molecular imprinting research and applications. It supplies a comprehensive tutorial for learning basic techniques and making new contributions to the field, as well as in-depth discussions, guidelines, and experimental protocols to help beginners gain a jump-start in the field of molecular imprinting. Molecularly Imprinted Materials: Science and Technology contains a multitude of experimental protocols illustrating specific techniques discussed in the text.
Molecularly Imprinted Polymers as Advanced Drug Delivery Systems: Synthesis, Character and Application
by Yi Yang Zhaosheng Liu Yanping HuangThis book summarizes the recent advancements for drug delivery systems (DDS) in terms of fundamental principles, rapidly emerging techniques and developing frontiers of molecular imprinting. Especially with the combination of enantioselective molecularly imprinted polymers and water compatible molecularly imprinted polymers, stimuli responsive imprinted DDS have been innovated and applied to dermal delivery, ophthalmic drugs and cancer treatment. This philosophy comprehensively revolutionizes the treatment strategy of human healthcare and provides the possibility to re-trigger in vivo an exhaust system after the complete release of the starting drug cargo, thus enabling precision medicine. To this end, the following unique features will be discussed and concluded: 1) State-of-the-art definition of MIP as drug delivery systems. 2) Advanced techniques and clinical applications of MIP as drug delivery systems in the past decade. 3) Novel frontiers and brand-new technologies, for example, drug delivery devices for zero-order sustained release and stimuli responsive imprinted DDS. 4) Revolutionary impact on dermal delivery, ophthalmic drugs and cancer treatment. 5) Future challenges and perspectives
Molecularly Imprinted Polymers as Artificial Antibodies for the Environmental Health: A Step Towards Achieving the Sustainable Development Goals
by Santanu Patra Mika SillanpaaThis book covers the fundamental principles of molecularly imprinted polymers (MIPs) and their synthesis methodologies, offering readers a solid understanding of these unique materials. It delves into the design and selection of template molecules for imprinting, as well as polymerization techniques and strategies for optimizing MIP performance. With a focus on real-world applications, the book showcases the wide range of environmental health problems that MIPs can address. It discusses the detection and quantification of pollutants in air, water, and soil using MIP-based sensors and biosensors. Additionally, it explores the use of MIPs in environmental remediation, such as the adsorption and removal of contaminants, as well as the development of MIP-based materials for water and soil treatment. The book also highlights the analytical applications of MIPs in environmental health, including separation and purification techniques, sample preparation, and preconcentration methods. It examines how MIPs can be integrated into analytical instrumentation and detection systems to enhance environmental analysis. By bringing together interdisciplinary knowledge from the fields of environmental science, chemistry, polymer science, analytical chemistry, and environmental engineering, this book provides readers with a comprehensive understanding of the potential of MIPs as artificial antibodies for environmental health. With its emphasis on real-world applications and case studies, it offers practical insights that researchers, academics, and professionals can apply in environmental monitoring, remediation, and analysis projects.
Molecularly Imprinted Polymers in Biotechnology
by Bo Mattiasson Lei YeControlled radical polymerization techniques for molecular imprinting, by Mark E. Byrne From bulk polymers to nanoparticles, by Lei Ye Post-imprinting and in-cavity functionalization, by Toshifumi Takeuchi Characterization of MIPs (affinity, selectivity, site heterogeneity. . . ), by Richard Ansell Theoretical aspects and computer modelling, by Ian Nicholls MIPs in aqueous environments, by Bin Lu MIPs for binding macromolecules, by Kenneth J. Shea Solid phase extraction, by Ecevit Yilmaz Sensors, by Sergey A. Piletsky MIPs for catalysis and synthesis, by Marina Resmini Wastewater treatment, by Bo Mattiasson MIPs as tools for bioassays, biotransformation and drug delivery, by Meiping Zhao
Molecularly Imprinted Polymers: Computational Studies to Advanced Applications (Springer Series on Polymer and Composite Materials)
by Zeynep AltintasThis book provides an overview of the latest technology and advances in the field of molecularly imprinted polymers (MIPs) and their diverse applications in healthcare diagnostics, food safety and quality, as well as environmental monitoring. Divided into 3 parts, the book offers an introduction to the basics of molecular imprinting and affinity materials, followed by an outline of the main sensor applications and the contribution of smart nanomaterials to molecular imprinting. The last part of the book compares MIP-based diagnostics technologies with antibody- and aptamer-based diagnostics, and discusses existing and further commercial opportunities for MIPs. Through this book, readers will get a wide range of information from basics to advanced applications in the molecular imprinting area and discover the impact of integrated approaches such as computational studies and nanotechnology on the development of imprinting techniques for biotechnological applications covering healthcare, environmental and food safety research. With its rich content, the book is a unique contribution to the field and it holds great potential to be a reference work not only for researchers working in the field but also for the researchers who plan to design collaborative research projects to contribute to their particular field (e.g., medical scientists, medical doctors, agricultural or food engineers).
Molecularly Imprinted Polymers: Methods and Protocols (Methods in Molecular Biology #2359)
by Antonio Martín-EstebanThis detailed volume explores molecularly imprinted polymers (MIPs), which have attracted great interest both in fundamental research and for practical applications due to their selective molecular recognition capabilities, extraordinary stability, and ease of preparation. Beginning with key laboratory protocols describing the different steps towards the synthesis of MIPs by different polymerization strategies, the volume continues by examining MIP use in sample preparation, their implementation on the development of sensors, as well as applications in other areas such catalysis and the use of bioinformatics and molecular modeling for MIPs design. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to the respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Molecularly Imprinted Polymers: Methods and Protocols serves as an ideal guide for researchers seeking to harness this very powerful approach for the preparation of molecular selective synthetic polymers.
Molecularly Imprinted Polymers: Path to Artificial Antibodies
by Mika Sillanpää Sudheesh K. Shukla Santanu PatraThe book delves into the intricate realm of Molecularly Imprinting Polymers (MIPs) functioning as artificial antibodies. The book explores several subjects, such as the basic principles, historical development, methods for creating and analyzing MIPs, creation of specific recognition sites, computational modeling, responsive behavior to stimuli, and the nano-scale applications of MIPs. Furthermore, it emphasizes the pivotal role of MIPs in the detection of cancer, infectious diseases, and the detection of bacteria and viruses. In addition, the book explores the field of different sensor technologies, specifically focusing on MIP-based electrochemical and optical sensors. It also highlights how these sensors might be integrated into wearable, flexible, and chip sensors. In addition, the book explores developing technologies and potential future applications of MIPs as artificial antibodies. This book offers a complete grasp of the promise and limitations of MIPs by providing insights into their challenges and real-time applications. The book will be a useful resource for researchers, students, professionals, and practitioners in bioengineering, biotechnology, medicine, and ethics.
Molecularly Targeted Therapy for Childhood Cancer
by Peter J. Houghton Robert J. ArceciEach chapter will focus on the known molecular characteristics of specific childhood cancers, focusing on how the molecular 'drivers' can be exploited from a therapeutic standpoint with currently available targeted agents. Where applicable, integration of targeted therapies with conventional cytotoxic agents will be considered. This volume will provide a comprehensive summary of molecular characteristics of childhood cancers, and how the changes involved in transformation provide us with opportunities for developing relatively less toxic, but curative, therapies.
Molecules Engineered Against Oncogenic Proteins and Cancer: Discovery, Design, and Development
by E. J. Corey Yong-Jin WuMolecules Engineered Against Oncogenic Proteins and Cancer A comprehensive review of the latest molecular advances in cancer treatment Featuring 91 total small molecule kinase/KRAS inhibitors, 80 of which are FDA-approved, Molecules Engineered Against Oncogenic Proteins and Cancer documents the recent scientific advances that have transformed one of medicine’s most challenging areas—cancer treatment. Most of these inhibitors specifically block oncogene-induced carcinogenic proteins with results that have dramatically advanced the treatment of cancer. In addition, the structural formulas of more than 100 kinase/KRAS inhibitors in clinical trials are presented. With a very well-known chemist as an author, Molecules Engineered Against Oncogenic Proteins and Cancer includes information on: Each molecule’s structure, function of the kinase target and relevance to cancer, the drug discovery process, and molecular details of drug action Mutated protein kinases as oncoproteins and targets for inhibition, along with the details of discovery for each antitumor antikinase agent History of oncoprotein inhibitors and their role in advancing the treatment and understanding of cancer The discovery process as a whole, effective strategies for innovation, ongoing challenges, and a glimpse of the future of the field Combining the most significant recent discoveries in a unique and useful way, Molecules Engineered Against Oncogenic Proteins and Cancer is an essential resource for researchers and students in bioscience, medicine, chemistry, and oncology as well as for those at industrial companies involved in therapeutic discovery.
Molecules Of Emotion
by Candace B. PertWhy do we feel the way we feel? How do our thoughts and emotions affect our health? Are our bodies and minds distinct from each other or do they function together as part of an interconnected system? In MOLECULES OF EMOTION, neuroscientist Candace Pert provides startling and decisive answers to these long-debated questions, establishing the biomolecular basis for our emotions and explaining these new scientific developments in a clear and accessible way. Her pioneering research on how the chemicals inside us form a dynamic information network, linking mind and body, is not only provocative, it is revolutionary. In her groundbreaking book, Candace Pert offers a new scientific understanding of the power of our minds and our feelings to affect our health and well-being.
Molecules Of Emotion
by Candace PertWhy do we feel the way we feel? How do our thoughts and emotions affect our health? Are our bodies and minds distinct from each other or do they function together as part of an interconnected system? In MOLECULES OF EMOTION, neuroscientist Candace Pert provides startling and decisive answers to these long-debated questions, establishing the biomolecular basis for our emotions and explaining these new scientific developments in a clear and accessible way. Her pioneering research on how the chemicals inside us form a dynamic information network, linking mind and body, is not only provocative, it is revolutionary. In her groundbreaking book, Candace Pert offers a new scientific understanding of the power of our minds and our feelings to affect our health and well-being.
Molecules Of Emotion
by Candace PertWhy do we feel the way we feel? How do our thoughts and emotions affect our health? Are our bodies and minds distinct from each other or do they function together as part of an interconnected system? In MOLECULES OF EMOTION, neuroscientist Candace Pert provides startling and decisive answers to these long-debated questions, establishing the biomolecular basis for our emotions and explaining these new scientific developments in a clear and accessible way. Her pioneering research on how the chemicals inside us form a dynamic information network, linking mind and body, is not only provocative, it is revolutionary. In her groundbreaking book, Candace Pert offers a new scientific understanding of the power of our minds and our feelings to affect our health and well-being.
Molecules That Amaze Us
by Simon Cotton Paul May"This new book is by two knowledgeable and expert popularizers of chemistry and deals exclusively with molecules and compounds rather than with the simpler atoms and elements. It is based on the very successfulMolecule of the Month' website that was begun by Paul May fifteen years ago and to which his co-author Simon Cotton has been a frequent co
Molecules and Medicine
by László Kürti Barbara Czakó E. J. CoreyMolecules and Medicine provides, for the first time ever, a completely integrated look at chemistry, biology, drug discovery, and medicine. It delves into the discovery, application, and mode of action of more than one hundred of the most significant molecules in use in modern medicine. Opening sections of the book provide a unique, clear, and concise introduction, which enables readers to understand chemical formulas.
Molecules and Radiation: An Introduction to Modern Molecular Spectroscopy. Second Edition (Dover Books on Chemistry)
by Jeffrey I. SteinfeldThis unified treatment introduces upper-level undergraduates and graduate students to the concepts and methods of modern molecular spectroscopy and their applications to quantum electronics, lasers, and related optical phenomena.Starting with a review of the prerequisite quantum mechanical background, the text examines atomic spectra and diatomic molecules, including the rotation and vibration of diatomic molecules and their electronic spectra. A discussion of rudimentary group theory advances to considerations of the rotational spectra of polyatomic molecules and their vibrational and electronic spectra; molecular beams, masers, and lasers; and a variety of forms of spectroscopy, including optical resonance spectroscopy, coherent transient spectroscopy, multiple-photon spectroscopy, and spectroscopy beyond molecular constants. The text concludes with a series of useful appendixes.