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Medicinal Applications of Phytopharmaceuticals
by Menka Khoobchandani Subhajit GhoshThis book is devoted to phytopharmaceuticals and their role in managing human disorders. It also covers the biological role of herbal drugs and the latest research developments in herbal medicine. Divided into five parts, the book starts with a global perspective on phytopharmaceuticals providing insights into the lessons from the past to the future, followed by an overview of Ayurveda medicine, and the main isolation and extraction techniques of plant material. Parts 2 and 3 present the latest research on natural products and phytopharmaceuticals, in which the authors cover the current clinical research status on formulations containing medicinal plants, and an overview of nanomedicines. Particular attention is given to potential and current therapeutic applications of phytopharmaceuticals, including their role in the management of COVID-19, neurological disorders, and cancer therapy. Part 4 focuses on the biomedical applications of phytochemical-based formulations, and Part 5 outlines the role and benefits of nutraceuticals in human health. The final chapter of this book provides an overview of the main toxicity and regulatory aspects of herbal medicines. Collating the latest advances in phytopharmaceuticals and natural product drug discovery with a perspective on Ayurveda therapies, this book has broad appeal from scholars,and researchers to professionals interested in plant-based drug development and phytochemistry.
Medicinal, Aromatic and Stimulant Plants (Handbook of Plant Breeding #12)
by Johannes Novak Wolf-Dieter BlüthnerThe agricultural sector of medicinal (including plant stimulants) and aromatic plants is characterized by an enormous number and diversity of species. Only a few of them can be considered cultivated crops in which significant breeding efforts are made. For most species, however, breeding is performed in short-term projects only. Therefore, basic knowledge about these species is still fragmentary. Our intention is to compile and organize the available information on the most commonly utilized plant species into one publication, thereby providing a standardized resource for the researchers and the grower community. This book therefore provides reference source materials for a wide variety of plant species used for human consumption due to their flavor, medicinal or recreational properties. It is divided into a section of general topics on genetic resources, breeding adaptation of analytic methods and a compilation of basic data for DNA content, chromosome number and mating system followed by a section of 20 monographs on a species or species groups.
Medicinal Chemistry: A Look at How Drugs Are Discovered
by A.K. Ganguly Sesha Sridevi AlluriMedicinal Chemistry: A Look at How Drugs Are Discovered is written for those who are interested in learning how drugs are discovered. Compared to other books on the market, this text takes a different approach by presenting the subject on chemical reaction mechanism terms, which ideally makes the subject matter more interesting and easier to comprehend. The authors describe the drug discovery process, from advancing an initial lead to the approval process, and include drug discovery sources. Additional features: Explains medicinal chemistry on chemical mechanism terms, allowing for a more interesting and easier to comprehend text Includes valuable insights toward the various pathways taken at pharmaceutical industries in drug discoveries Improved by including questions raised and suggestions made from students in the authors’ medicinal chemistry classes This book will benefit both upper level undergraduates and graduates studying in the fields of medicinal chemistry and drug discovery, as well as scientists working in the pharmaceutical industry.
Medicinal Chemistry
by Gareth ThomasMedicinal Chemistry: An Introduction, Second Edition provides a comprehensive, balanced introduction to this evolving and multidisciplinary area of research. Building on the success of the First Edition, this edition has been completely revised and updated to include the latest developments in the field.Written in an accessible style, Medicinal Chemistry: An Introduction, Second Edition carefully explains fundamental principles, assuming little in the way of prior knowledge. The book focuses on the chemical principles used for drug discovery and design covering physiology and biology where relevant. It opens with a broad overview of the subject with subsequent chapters examining topics in greater depth.From the reviews of the First Edition:"It contains a wealth of information in a compact form" ANGEWANDTE CHEMIE, INTERNATIONAL EDITION"Medicinal Chemistry is certainly a text I would chose to teach from for undergraduates. It fills a unique niche in the market place." PHYSICAL SCIENCES AND EDUCATIONAL REVIEWS
Medicinal Chemistry Approaches to Personalized Medicine
by Bruce Roth Hugo Kubinyi Karen Lackey Gerd Folkers Raimund MannholdEdited by two renowned medicinal chemists who have pioneered the development of personalized therapies in their respective fields, this authoritative analysis of what is already possible is the first of its kind, and the only one to focus on drug development issues.Numerous case studies from the first generation of "personalized drugs" are presented, highlighting the challenges and opportunities for pharmaceutical development. While the majority of these examples are taken from the field of cancer treatment, other key emerging areas, such as neurosciences and inflammation, are also covered.With its careful balance of current and future approaches, this handbook is a prime knowledge source for every drug developer, and one that will remain up to date for some time to come.From the content:* Discovery of Predictive Biomarkers for Anticancer Drugs* Discovery and Development of Vemurafenib* Targeting Basal-Cell Carcinoma* G-Quadruplexes as Therapeutic Targets in Cancer* From Human Genetics to Drug Candidates: An Industrial Perspective on LRRK2 Inhibition as a Treatment for Parkinson's Disease* Therapeutic Potential of Kinases in Asthma* DNA Damage Repair Pathways and Synthetic Lethality* Medicinal Chemistry in the Context of the Human Genomeand many more
Medicinal Chemistry for Practitioners
by Jie Jack LiPresenting both a panoramic introduction to the essential disciplines of drug discovery for novice medicinal chemists as well as a useful reference for veteran drug hunters, this book summarizes the state-of-the-art of medicinal chemistry. It covers key drug targets including enzymes, receptors, and ion channels, and hit and lead discovery. The book hen surveys a drug's pharmacokinetics and toxicity, with a solid chapter covering fundamental bioisosteres as a guide to structure-activity relationship investigations.
The Medicinal Chemistry of Glucocorticoid Receptor Modulators (SpringerBriefs in Molecular Science)
by Adrian HobsonThis book covers the design and development of glucocorticoid receptor modulators (GRM) from cortisol to antibody-drug conjugate payloads over the last 70 years. The author starts with an introduction to the background of glucocorticoid receptor modulators as potential therapeutic modalities. This is followed by seven chapters in which he collates and discusses the medicinal chemistry journey of GRMs, reviewing topics such as cortisol-based glucocorticoids, the different approaches that have been pursued to enable chronic dosing of GRM compounds by inactivation in plasma and the liver, the application of prodrugs to GRMs, selective GRMs, targeted delivery of GRMs using polymers and nanoparticles, and rational drug design approaches applied in the development of GRMs. Particular attention is given to the development of glucocorticoid receptor modulators as immunology antibody-drug conjugate payloads. In the book’s final chapter, the author critiques the medicinal chemistry progress made since the discovery of cortisone and the promise of the latest antibody-drug conjugates that release a GRM payload. In this book, readers will also find an overview of the X-ray structures of glucocorticoid receptor antagonists and a list of all the earlier reviews that cover part of the medicinal chemistry story of GRM collated by keywords organized in a table. With several examples of crystal structures and molecular modeling, this book illustrates the huge effort by multiple companies and research groups to develop glucocorticoid receptor modulators. Professionals and scholars alike will find it a handy tool, and appreciate the latest research findings that it presents.
Medicinal Chemistry of Neglected and Tropical Diseases: Advances in the Design and Synthesis of Antimicrobial Agents
by Venkatesan Jayaprakash Daniele Castagnolo Yusuf OzkayMedicinal Chemistry of Neglected and Tropical Diseases: Advances in the Design and Synthesis of Antimicrobial Agents consolidates and describes modern drug discovery and development approaches currently employed to identify effective chemotherapeutic agents for the treatment of Neglected Tropical Diseases (NTDs) from a medicinal chemistry perspective. Chapters are designed to cater to the needs of medicinal chemists who work with chemotherapeutic developments for NTDs, as well as serve as a guide to budding medicinal chemists who wish to work in this area. It will introduce rational drug design approaches adopted in designing chemotherapeutics and validated targets available for the purpose.
Medicinal Herbs and Fungi: Neurotoxicity vs. Neuroprotection
by Dinesh Chandra Agrawal Muralikrishnan DhanasekaranThe ever-rising increase in the consumption of medicinal herbs and its products and its exposure in the human population have generated concerns about the potential neurotoxicity of several new and existing botanicals. This book offers an accurate, relevant, and comprehensive coverage of a wide variety of medicinal herbs and fungi affecting the central and peripheral nervous system. It includes review articles that thoroughly describe the benefits and adverse effects of some of the most commonly used medicinal herbs and fungi, and the pathophysiological mechanisms underlying them. The book provides an all-inclusive overview of the diverse aspects of medicinal herbs and fungi related to neurotoxicity and/or neuroprotection, ranging from discussions of cellular and molecular processes and pathology to clinical aspects. The rich compilation brings together thorough and extensive research updates on the advances in the field. The chapters have been contributed by the experienced and eminent academicians, researchers, and scientists working in the field across the globe.
Medicinal Mushrooms: Recent Progress in Research and Development
by Dinesh Chandra Agrawal Muralikrishnan DhanasekaranPresents the latest R & D information on medicinal mushrooms from diverse geographical locationsOffers comprehensive coverage of the most important application areas of medicinal mushroomsIncludes contributions by eminently experienced researchers in the field of medicinal mushrooms Medicinal mushrooms are increasingly gaining attention worldwide because of their pharmacologically bioactive compounds, which have demonstrated potent and unique clinical properties. Scientific studies carried out during the last decade have confirmed their efficacy in treating a wide range of diseases. Extracts and bioactive compounds obtained from mushrooms have been used medicinally as anticancer, immunomodulator, antibacterial, antiviral, anti-inflammatory, anti-atherosclerotic, neuroprotectant, cardioprotectant, antioxidant, and anti-hypoglycemic agents, and in stem cell-based therapies.Introducing readers to the latest developments in, and ongoing research efforts on, medicinal mushrooms, this book gathers articles contributed by eminent researchers in different disciplines and from around the globe. Highlighting the tremendous potential of mushrooms for the development of new drugs, the topics covered include but are not limited to: Recent progress in research on the pharmaceutical potential of medicinal mushrooms and prospects for their clinicalapplication Edible mushroom neuronutraceuticals: Basis of therapeutics Overview of therapeutic efficacy of mushrooms Mushrooms – a wealth of resources for prospective stem cell-based therapies Mushrooms as potential natural cytostatics
Medicinal Natural Products
by Paul M. DewickMedicinal Natural Products: A Biosynthetic Approach, Third Edition, provides a comprehensive and balanced introduction to natural products from a biosynthetic perspective, focussing on the metabolic sequences leading to various classes of natural products. The book builds upon fundamental chemical principles and guides the reader through a wealth of diverse natural metabolites with particular emphasis on those used in medicine.There have been rapid advances in biosynthetic understanding over the past decade through enzymology, gene isolation and genetic engineering. Medicinal Natural Products has been extended and fully updated in this new edition to reflect and explain these developments and other advances in the field. It retains the user-friendly style and highly acclaimed features of previous editions:a comprehensive treatment of plant, microbial, and animal natural products in one volumeextensive use of chemical schemes with annotated mechanistic explanationscross-referencing to emphasize links and similaritiesboxed topics giving further details of medicinal materials, covering sources, production methods, use as drugs, semi-synthetic derivatives and synthetic analogues, and modes of actionMedicinal Natural Products: A Biosynthetic Approach, Third Edition, is an invaluable textbook for students of pharmacy, pharmacognosy, medicinal chemistry, biochemistry and natural products chemistry.
Medicinal Orchids of Asia
by Eng Soon TeohThis unique book brings together a wealth of data on the botanical, ethno-medicinal and pharmacological aspects of over 500 species of Asian medicinal orchids. It starts off by explaining the role and limitations of complimentary and herbal medicines, and how traditional Asian medicine differs from Western, "scientific" medicine. The different Asian medical traditions are described, as well as their modes of preparing herbal remedies. The core of the book presents individual medicinal orchid species arranged by genera. Each species is identified by its official botanical name, synonyms, and local names. Its distribution, habitat and flowering season, uses and pharmacology are described. An overview sums up the research findings on all species within each genus. Clinical observations are discussed whenever available, and possible therapeutic applications are highlighted. The book closes with chapters on the conservation of medicinal orchids and on the role of randomized clinical trials.
Medicinal Organometallic Chemistry
by Gérard Jaouen Nils Metzler-NolteContents: Gérard Jaouen, Nils Metzler-Nolte : Introduction ; Stéphane GIBAUD and Gérard JAOUEN: Arsenic - based drugs: from Fowler's solution to modern anticancer chemotherapy; Ana M. Pizarro, Abraha Habtemariam and Peter J. Sadler : Activation Mechanisms for Organometallic Anticancer Complexes; Angela Casini, Christian G. Hartinger, Alexey A. Nazarov, Paul J. Dyson : Organometallic antitumour agents with alternative modes of action; Elizabeth A. Hillard, Anne Vessières, Gerard Jaouen : Ferrocene functionalized endocrine modulators for the treatment of cancer; Megan Hogan and Matthias Tacke : Titanocenes - Cytotoxic and Anti-Angiogenic Chemotherapy Against Advanced Renal-Cell Cancer; Seann P. Mulcahy and Eric Meggers : Organometallics as Structural Scaffolds for Enzyme Inhibitor Design; Christophe Biot and Daniel Dive : Bioorganometallic Chemistry and Malaria; Nils Metzler-Nolte : Biomedical applications of organometal-peptide conjugates; Roger Alberto : Organometallic Radiopharmaceuticals; Brian E. Mann : Carbon Monoxide - an essential signaling molecule.
Medicinal Plant Biodiversity of Lesser Himalayas-Pakistan
by Mushtaq Ahmad Mir Ajab Khan Arshad Mehmood Abbasi Muhammad ZafarThe Himalayan region is among the largest mountains systems of the world with uncounted unique medicinal plants resources. The lesser Himalayas ranges are the extension of Greater Himalayas. They have unique ecology, vegetation and diversity of medicinal flora due to tremendous variation in the altitude, climate and associated wildlife. The utilization of medicinal plants in medicine suffers from the fact that although plants are used to treat diseases, scientific evidence is lacking in many cases. Different societies of the world use the plants according to their own beliefs and knowledge and previous experiences. Their knowledge about the use of the plants is usually not known to the other world or science. This book provides a brief introduction of Lesser Himalayas, ethnobotanical aspects, marketing and anthropogenic pressure on medicinal flora. It comprises one hundred medicinal plant species including Pteridophytes, Gymnosperms and Angiosperms (Monocots and Dicots) along with their scientific description and traditional uses.
The Medicinal Plant Industry
by R. O. WijesekeraAs the medicinal plant industry blooms into a billion dollar business, it reaches beyond collection, propagation, harvesting and sale of crude vegetal drugs into product formulation, packaging and dispensing of sophisticated phyto-pharmaceuticals and herbal preparations. The scientific study of these medicines and the systematic uplifting of the industry to preserve the ancient and serve the modern, is now a global challenge.The Medicinal Plant Industry puts together the various facets of this multi-disciplinary industry and its global interest. It discusses the dire need for developing countries to acquire technologies and techniques for programmed cultivation of medicinal plants. It addresses a wide variety of topics including the old philosophies, modern impact of traditional medicines, and methods of assessing the spontaneous flora for industrial utilization. It covers aspects of cultivation and climatic variations, biological assessment and formulation, process technologies, phytochemical research and information sources. The book reviews highly developed traditional medicine in China and India, and covers experiences in Africa and other continents.
Medicinal Plant Responses to Stressful Conditions (Exploring Medicinal Plants)
by Abdel Latef, Arafat Abdel HamedMedicinal Plant Responses to Stressful Conditions discusses the effects of multiple biotic and abiotic stressors on medicinal plants. It features information on biochemical, molecular and physiological strategies used to mitigate or alleviate detrimental effects of biotic and abiotic stressors. The book contains chapters featuring medicinal plants of importance covering subjects including genomics, functional genomics, metabolomics, phenomics, proteomics and transcriptomics under biotic and abiotic stress of medicinal plants and their molecular responses. It suggests exogenous application of different types of stimulants to enhance medicinal plant production in such conditions. Features: Details all aspects of biotic and abiotic stressors in various important medicinal plant species. Chapters cover evidence-based approaches in the diagnosis and management of medicinal plants under stressful conditions. Includes information on ways to mitigate effects from biotic stress (diseases and pests) or abiotic stress (high salinity, drought, temperature extremes, waterlogging, wind, high light intensity, UV radiation, heavy metals and mineral deficiencies). A volume in the Exploring Medicinal Plants series, this book is an essential resource for plant scientists, botanists, environmental scientists and anyone with an interest in herbal medicine.
Medicinal Plants: Domestication, Biotechnology and Regional Importance (Sustainable Development and Biodiversity #28)
by Halina Maria Ekiert Kishan Gopal Ramawat Jaya AroraMedicinal plant research is an evergreen subject. There is a tremendous increase in popularity of herbal medicine in traditional medicine, ethnomedicine, modern medicine and as over the counter food supplements. Even after this increased demand, supply is neither uniform nor assured as most of these plants are collected from wild. In developing countries of tropical and subtropical regions where majority of herbal drugs are produced, this is not organised sector making it vulnerable to several malpractices, hence standardization of all aspects required. This has also negative impact on biodiversity and conservation of plants as well as supply of uniform material. This book is aimed to provide up to date information about sustainable use of selected medicinal plants, their active ingredients and efforts made to domesticate them to ensured uniform supply. Development of agrotechnology, biotechnology and cultivation practices using conventional and non-conventional methods are presented. Where these efforts will lead the medicinal plant research and future perspective are discussed. The chapters are written by well recognised group leaders in working in the field. The book contains topics on general biology of medicinal plants, their sustainable use and, cultivation and domestication efforts. A uniform chapter structure has been designed to keep consistency. The book will be useful for academicians, agriculturists, biotechnologists and researcher, and industries involved in manufacturing herbal drugs and supplementary products.
Medicinal Plants: Their Response to Abiotic Stress
by Azamal Husen Muhammad IqbalThis book provides a comprehensive overview of medicinal plants and their interaction with abiotic stress in terms of morphological, physiological, biochemical, and molecular variations, and explains the adaptation and tolerance mechanisms involved. It presents various mechanisms that become operative in medicinal plants to combat stressful situations. The book discusses the secondary metabolites and/or bioactive compounds produced in medicinal plants under abiotic stress conditions, and the use of biostimulants and/or phytoprotectants to alleviate the adverse effects of abiotic stresses on medicinal plants. Additionally, it is likely to address opportunities and challenges in molecular and omics studies of medicinal plants under abiotic stress conditions. Overall, the chapters are developed by eminent subject experts with due care and clarity and cover an up-to-date literature review with relevant illustrations. The book would cater to the need of graduate and post-graduate students, researchers as well as scientists, and may attract the attention of pharmaceutical companies/industrialists and health policymakers.
Medicinal Plants: From Farm to Pharmacy
by Nirmal Joshee Sadanand A. Dhekney Prahlad ParajuliThis book offers a fresh look on a variety of issues concerning herbal medicine - the methods of growing and harvesting various medicinal plants; their phytochemical content; medicinal usage; regulatory issues; and mechanism of action against myriad of human and animal ailments. ‘Medicinal Plants: From Farm to Pharmacy’ comprises chapters authored by renowned experts from academics and industry from all over the world. It provides timely, in-depth study/analysis of medicinal plants that are already available in the market as supplements or drug components, while also introducing several traditional herbs with potential medicinal applications from various regions of the world. The book caters to the needs of a diverse group of readers: plant growers, who are looking for ways to enhance the value of their crops by increasing phytochemical content of plant products; biomedical scientists who are studying newer applications for crude herbal extracts or isolated phytochemicals; clinicians and pharmacologists who are studying interactions of herbal compounds with conventional treatment modalities; entrepreneurs who are navigating ways to bring novel herbal supplements to the market; and finally, natural medicine enthusiasts and end-users who want to learn how herbal compounds are produced in nature, how do they work and how are they used in traditional or modern medicine for various disease indications.
Medicinal Plants: Culture, Utilization and Phytopharmacology
by Thomas S. LiMedicinal Plants: Culture, Utilization and Phytopharmacology covers over 400 species. Each chapter gathers valuable information from a wide variety of sources, and supplies it to the user in convenient table format, arranged alphabetically by scientific name, followed by the common name. Data topics include: major constituents (active ingredients)
Medicinal Plants: Chemistry, Pharmacology, and Therapeutic Applications
by Jayanta Kumar Patra Mallappa Kumara Swamy Gudepalya Renukaiah RudramurthyThis book details several important medicinal plants, their occurrence, plant compounds and their chemical structures, and pharmacological properties against various human diseases. It also gives information on isolation and structural elucidation of phytocompounds, bio-assays, metabolomic studies, and therapeutical applications of plant compounds.
Medicinal Plants: Promising Future for Health and New Drugs
by Parimelazhagan ThangarajThis book highlights the importance of traditional medicines, focuses on the standardization of herbal medicine and evaluates opportunities for advancing drug research. It addresses issues in utilization of medicinal plants and shares the importance of herbs in neutraceutics. It provides most competitive techniques being used in research.
Medicinal Plants and Antimicrobial Therapies
by Vinay Kumar Varsha Shriram Abhijit DeyThis book serves as an excellent comprehensive material covering the current understandings and updates on antimicrobial resistance (AMR) and the use of medicinal plant resources for tackling it. Chapters cover important aspects of AMR and strategies to address this threatening issue with medicinal plants and their resources. One health perspectives for addressing AMR have been presented for the readers. Antimicrobial medicinal plant therapeutic resources including crude extracts, active fractions, pure molecules and essential oils, besides using them as functionalizing agents for nano-antimicrobials have been covered. Further, plant endophytes as a source of antimicrobial compounds have been discussed. Chapters cover both the bactericidal as well as resistance-reversal (or potentiating/ combinatorial therapies) potencies of medicinal plant resources. The book also focuses on how medicinal plant resources effectively target major determinants of AMR. Use of metabolomics in understanding and targeting AMR mechanisms and identifying potent phyto-therapeutics has been discussed as well. The book is a valuable read for both experienced and younger researchers working in the field of AMR and related fields in biomedicine, pharmacy, and clinical research.
Medicinal Plants and Malaria: Applications, Trends, and Prospects (Traditional Herbal Medicines For Modern Times Ser.)
by Woon-Chien Teng Ho Han Kiat Rossarin Suwanarusk Hwee-Ling KohMalaria is a potentially life-threatening disease that affects millions worldwide, especially in Sub-Saharan Africa. The recent emergence and spread of multidrug resistance in parts of Southeast Asia prompts the urgent need for novel and effective therapy against the disease. Medicinal Plants and Malaria: Applications, Trends, and Prospects highlig
Medicinal Plants and Mushrooms of Yunnan Province of China (Natural Products Chemistry of Global Plants)
by Clara Bik-San Lau and Chun-Lin LongAlthough many texts describe plants from China, the focus of this book is to draw on the rich culture and environment of medicinal plants and fungi/mushrooms of Yunnan Province. In fact, Yunnan Province covers two global hotspots of biodiversity, with the richest biological and cultural diversity in China. In particular, the Kunming Institute of Botany (KIB) of the Chinese Academy of Sciences (founded in 1938 and located in the capital city of Yunnan Province) has made great contributions in the fields of botany and phytochemistry, earning an international reputation. This book covers those medicinal plants and fungi/mushrooms specific to Yunnan Province, and is written mainly by KIB experts in this research field. Key Features: Distinct sections cover the breadth of the topic including resource availability (wildly grown or cultivated), sustainability, and distribution Discusses plant parts used for medicinal uses (the folklore, the ancient and modern uses) Describes the important natural products and the known pharmacologically active components Presents biological activities related to medicinal uses or clinical evidence Cover image: Shilin, the stone forest (eroded vertical pinnacles of limestone), landmark of Kunming, Yunnan.