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Mechanism in Protein Chemistry
by Jack KyteDescribes proteins' physical and chemical nature and how their molecular structures can be determined experimentally. Intended for upper level undergraduate and graduate students with a background in chemistry or biochemistry.
Mechanism, Life and Mind in Modern Natural Philosophy (International Archives of the History of Ideas Archives internationales d'histoire des idées #240)
by Charles T. Wolfe Paolo Pecere Antonio ClericuzioThis volume emphasizes the diversity and fruitfulness of early modern mechanism as a program, as a concept, as a model. Mechanistic study of the living body but also of the mind and mental processes are examined in careful historical focus, dealing with figures ranging from the first-rank (Bacon, Descartes, Spinoza, Cudworth, Gassendi, Locke, Leibniz, Kant) to less well-known individuals (Scaliger, Martini) or prominent natural philosophers who have been neglected in recent years (Willis, Steno, etc.). The volume moves from early modern medicine and physiology to late Enlightenment and even early 19th-century psychology, always maintaining a conceptual focus. It is a contribution to a newly active field in the history and philosophy of early modern life science. It is of interest to scholars studying the history of medicine and the development of mechanistic theories.
Mechanism of Fires: Chemistry and Physical Aspects
by Ali S. Rangwala Vasudevan RaghavanThis textbook on fire dynamics provides a comprehensive description of fuels involved in fires, definitions related to fire, thermodynamics for fire calculations, basics of transport processes and fundamental aspects of combustion related to fire, physical descriptions of premixed and non-premixed flames, detailed analysis of the characteristics of fires from solid and liquid fuels, including ignition, spread and burning rates and physical aspects of fire plumes, compartment fires and dust fires. The contents also highlight fundamental aspects related to the evaporation of liquid fuels and pyrolysis of solid fuels which are explained with simplified mathematical expressions. The book includes pedagogical features such as worked examples to illustrate mathematical calculations involved in fire analysis and end-of-chapter review questions. This book proves useful for students, researchers and industry professionals alike.
Mechanism of Functional Expression of F1-ATPase (SpringerBriefs in Molecular Science)
by Masahiro KinoshitaThis book presents a new view of the mechanism of functional expression of ATP-driven motors (proteins or protein complexes). It is substantially different from the prevailing idea that the motor converts chemical energy to mechanical work. To facilitate understanding, the differences between the new and prevailing views are explained using many illustrations. The book is of interest to those who are not convinced of the notion of chemo–mechanical coupling. The claims presented are the following: The system, which comprises not only the motor but also water, does no mechanical work during the ATP hydrolysis cycle; a protein is moved or a protein in the complex is rotated by the entropic force generated by water. The highlight of the explanation in the book is that the mechanism of unidirectional rotation of the central shaft in F1-ATPase is discussed in detail on the basis of this new view. The hydration entropy of each β subunit to which a specific chemical compound (ATP, ADP and Pi, Pi, or nothing) is bound, the hydration entropy of the α3β3 complex, and the dependence of the hydration entropy of F1-ATPase on the orientation of the γ subunit play essential roles.
Mechanism of Hairpin Vortex Formation by Liutex (Synthesis Lectures on Engineering, Science, and Technology)
by Yifei Yu Chaoqun LiuThis book presents the importance of the mechanism of hairpin vortex formation to understanding flow transition, turbulence, and flow control. This book blends direct numerical simulation (DNS) and mathematical analysis with experiments to create a foundation for understanding turbulence. The authors discuss hairpin vortex as a main component of transitional flow and turbulent flow. In addition, Liutex is utilized and described as a theoretical system that presents valid tools for turbulence research. Readers are exposed to understanding 3D and non-linear instability; the Lambda vortex formation; sweeps, ejections, and shear instability; the Kelvin-Helmholtz instability and vortex ring formation; and turbulence generation and sustenance.
Mechanism of Plant Hormone Signaling under Stress
by Girdhar K. PandeyPlant hormone signaling plays an important role in many physiological and developmental processes including stress response. With the advent of new post-genomic molecular techniques, the potential for increasing our understanding of the impact of hormone signaling on gene expression and adaptive processes has never been higher. Unlocking the molecular underpinnings of these processes shows great promise for the development of new plant biotechnologies and improved crop varieties. The topics included in this book emphasize on genomics and functional genomics aspects, to understand the global and whole genome level changes upon particular stress conditions. With the functional genomics tools, the mechanism of phytohormone signaling and their target genes can be defined in a more systematic manner. The integrated analysis of phytohormone signaling under single or multiple stress conditions may prove exceptional to design stress tolerant crop plants in the field conditions. Bringing together the latest advances, as well as the work being done to apply these findings to plant and crop science, Mechanism of Plant Hormone Signaling Under Stress will prove extremely useful to plant and stress biologists, plant biotechnology researchers, as well as students and teachers.
Mechanisms and Concepts in Toxicology
by W. Norman AldridgeIllustrating concepts and types of toxicity from a mechanistic point of view, this book focuses on research procedures in toxicology. The book uses examples of chemical intoxicants to illustrate mechanisms in each stage of toxicity.
Mechanisms and Games for Dynamic Spectrum Allocation
by Tansu Alpcan Holger Boche Michael L. Honig H. Vincent Poor Tansu Alpcan Holger Boche Michael L. HonigPresenting state-of-the-art research into methods of wireless spectrum allocation based on game theory and mechanism design, this innovative and comprehensive book provides a strong foundation for the design of future wireless mechanisms and spectrum markets. Prominent researchers showcase a diverse range of novel insights and approaches to the increasing demand for limited spectrum resources, with a consistent emphasis on theoretical methods, analytical results and practical examples. Covering fundamental underlying principles, licensed spectrum sharing, opportunistic spectrum sharing, and wider technical and economic considerations, this singular book will be of interest to academic and industrial researchers, wireless industry practitioners, and regulators interested in the foundations of cutting-edge spectrum management.
Mechanisms for CO2 Sequestration in Geological Formations and Enhanced Gas Recovery
by Roozbeh KhosrokhavarThis book gives background information why shale formations in the world are important both for storage capacity and enhanced gas recovery (EGR). Part of this book investigates the sequestration capacity in geological formations and the mechanisms for the enhanced storage rate of CO2 in an underlying saline aquifer. The growing concern about global warming has increased interest in geological storage of carbon dioxide (CO2). The main mechanism of the enhancement, viz. , the occurrence of gravity fingers, which are the vehicles of enhanced transport in saline aquifers, can be visualized using the Schlieren technique. In addition high pressure experiments confirmed that the storage rate is indeed enhanced in porous media. The book is appropriate for graduate students, researchers and advanced professionals in petroleum and chemical engineering. It provides the interested reader with in-depth insights into the possibilities and challenges of CO2 storage and the EGR prospect.
Mechanisms for Long-Term Innovation: Technology and Business Development of Reverse Osmosis Membranes (Advances in Japanese Business and Economics #31)
by Masatoshi Fujiwara Yaichi AoshimaThis book explores how a long-term innovation can take place based on historical analyses of the development of reverse osmosis (RO) membrane from the early 1950s to the mid-2010s. The RO membrane is a critical material for desalination that is a key to solve water shortages becoming serious in many places of the world. The authors conducted in-depth field studies as well as analyses of rich archival data to demonstrate how researchers, engineers, managers, entrepreneurs, and policymakers interacted each other for this material innovation to be realized. A series of historical analyses in this book uncovered that initial government supports, strategic niche markets, emergence of breakthrough technology, and company-specific rationales played significant roles for companies to overcome four types of uncertainty, technological, market, competition, and social/organizational ones, and enabled the companies to persistently invest in the development and commercialization of the RO membrane. This book depicts that innovation does not arise on a sudden, but that it is actualized through long lasting process with turns and twists, which is driven by many non-economic rationales beyond economic motives.
Mechanisms in Molecular Biology (Elements in the Philosophy of Biology)
by Tudor BaetuThe new mechanistic philosophy is divided into two largely disconnected projects. One deals with a metaphysical inquiry into how mechanisms relate to issues such as causation, capacities and levels of organization, while the other deals with epistemic issues related to the discovery of mechanisms and the intelligibility of mechanistic representations. Tudor Baetu explores and explains these projects, and shows how the gap between them can be bridged. His proposed account is compatible both with the assumptions and practices of experimental design in biological research, and with scientifically accepted interpretations of experimental results.
Mechanisms in Science: Method or Metaphysics?
by Stavros Ioannidis Stathis PsillosIn recent years what has come to be called the 'New Mechanism' has emerged as a framework for thinking about the philosophical assumptions underlying many areas of science, especially in sciences such as biology, neuroscience, and psychology. This book offers a fresh look at the role of mechanisms, by situating novel analyses of central philosophical issues related to mechanisms within a rich historical perspective of the concept of mechanism as well as detailed case studies of biological mechanisms (such as apoptosis). It develops a new position, Methodological Mechanism, according to which mechanisms are to be viewed as causal pathways that are theoretically described and are underpinned by networks of difference-making relations. In contrast to metaphysically inflated accounts, this study characterises mechanism as a concept-in-use in science that is deflationary and metaphysically neutral, but still methodologically useful and central to scientific practice.
Mechanisms Linking Aging, Diseases and Biological Age Estimation
by Sara C. ZapicoThis book focuses on four of the hallmarks of aging: aspartic acid racemization, advanced glycation end products, telomere shortening and mitochondrial mutations; describing their role in aging and diseases; and their application to age-at-death estimation in forensic sciences in greater depth, displaying the interconnecting pathways among these processes. An additional chapter related to Epigenetics and its role in aging, diseases, and forensic age estimation is also included. This book is aimed at a broad audience: from students being introduced to aging, diseases, and forensic science research to scientists in biomedicine and forensics complementing their knowledge in their respective fields while also increasing their knowledge in other disciplines.
Mechanisms of Arsenic Toxicity and Tolerance in Plants
by Mirza Hasanuzzaman Kamrun Nahar Masayuki FujitaArsenic is likely the most talked-about metalloid in the modern world because of its toxic effects on both animal and plants. Further, arsenic pollution is now producing negative impacts on food security, especially in many south Asian countries. Since plants are a major food source, their adaptation to As-rich environments is essential, as is being informed about recent findings on multifarious aspects of the mechanisms of arsenic toxicity and tolerance in plants. Although numerous research works and review articles have been published in journals, annual reviews and as book chapters, to date there has been no comprehensive book on this topic.This book contains 19 informative chapters on arsenic chemistry, plant uptake, toxicity and tolerance mechanisms, as well as approaches to mitigation. Readers will be introduced to the latest findings on plant responses to arsenic toxicity, various tolerance mechanisms, and remediation techniques. As such, the book offers a timely and valuable resource for a broad audience, including plant scientists, soil scientists, environmental scientists, agronomists, botanists and molecular biologists.
Mechanisms of Circadian Systems in Animals and Their Clinical Relevance
by Raúl Aguilar-Roblero Mauricio Díaz-Muñoz María Luisa Fanjul-MolesWell known experts in the field of Chronobiology from around the world, provide an integrative view of the state of the art of circadian biology. At present, genetic and epigenetic interaction of regulatory pathways among circadian oscillators, metabolic networks, cellular differentiation and neuronal communication are subject of intense scrutiny. The book is organized in three sections: The first includes selected examples of the circadian systems of crustaceans, insects, fish, birds and mammals. The second is a detailed view of the physiological mechanisms underlying the circadian clocks in mammals. Finally, in the third section some examples of the relevance of circadian biology and circadian misalignment to health and disease are provided including nutrition and metabolism, obesity, cancer, cardiovascular and pulmonary diseases, Huntington and affective diseases. This section concludes with a brief review on gene therapy and its potential use as a therapeutic tool to correct "clock genes" pathologies. This book is aimed at all those interested in contemporary aspects of physiology, biochemistry and molecular biology applied to the study and characterization of timing systems. . It could be used as an initial approach to this field, but it also provides updated information for those already familiar with the fascinating field of Chronobiology.
Mechanisms of Diffusional Phase Transformations in Metals and Alloys
by Hubert I. Aaronson Masato Enomoto Jong K. LeeDeveloped by the late metallurgy professor and master experimentalist Hubert I. Aaronson, this collection of lecture notes details the fundamental principles of phase transformations in metals and alloys upon which steel and other metals industries are based. Mechanisms of Diffusional Phase Transformations in Metals and Alloys is devoted to solid-s
Mechanisms of Drug Resistance in Cancer Therapy (Handbook of Experimental Pharmacology #249)
by Mario Mandalà Emanuela RomanoA major objective of this book is to reveal unprecedented opportunities to understand and overcome drug resistance through the clinical assessment of rational therapeutic drug combinations and the use of predictive and prognostic biomarkers to enable patient stratification and tailor treatments. It offers to the readers an updated overview on the possible reasons of failure of new and promising therapeutic opportunities.
Mechanisms of Environmental Stress Resistance in Plants
by Amarjit S. Basra Ranjit K. BasraPlant growth and productivity are limited in many areas of the world by a wide variety of environmental stresses. This book discusses progress made toward the major goal of uncovering the plant resistance mechanisms to biotic and abiotic stresses; the purpose being to utilise this knowledge in genetic modification of plants for achieving improved stress resistance. This volume achieves a new synthesis in considering the mechanisms of resistance at various levels of organisation -- from individual cells and tissues, through whole plants, to communities. Chapters are written by internationally acknowledged experts, who have a wealth of research and teaching experience. With comprehensive and up-to-date coverage, this book analyses many outstanding problems and poses important questions for future research.
Mechanisms of Everyday Cognition
by James M. Puckett Hayne W. ReeseBased on the proceedings of the twelfth biennial conference on life-span developmental psychology, most of the contributions in this volume deal with the mechanisms of everyday cognition. However, a broad spectrum of additional concerns is addressed within the domain of everyday cognition: its metatheoretical underpinnings, theory and theoretical issues, methods of investigation, empirical considerations, and social issues and applications. Addressing everyday cognition in infancy, childhood, adolescence, young and middle adulthood, and old age, this book is consistent with the chronological life-span theme of this series. The contributors collectively discuss some of the traditional concerns of life-span psychology: the dialectical nature of everyday cognition, individual differences, and contextual influences. Leading and concluding chapters provide overview, integration, and summary. In bringing together a wide array of age periods and points of view within the domain of everyday cognition, the editors hope that students and researchers in developmental psychology and cognitive science will find a useful cross-fertilization of ideas. A huge variety of theoretical perspectives is presented ranging from the position that everyday cognition and academic (laboratory) cognition are different manifestations of the same underlying processes to the position that the underlying processes are completely separate. Also of importance, a large assortment of research methods is illustrated including interviews, laboratory simulations, real-life observations and psychometric methods.
Mechanisms of Forest Ecosystems Sustainability in a Changing Climate: Complete Triad of Ecological Monitoring
by Erland G. KolomytsThe author's working concept of geo-ecological monitoring is presented. For the first time, the full triad of monitoring in its classical definition is considered: "observation (state assessment) – control (prediction) – management (adaptation, feedback, regulation)". The strategic goal of described monitoring research is to reveal the environmental otential of sustainablility of forest ecosystems in the context of modern global warming. The monograph expounds the main statements of author’s topo-ecological predictive concept: “Global Changes on the Local Level”, as a basis of ground bio-ecological and geosystem monitoring of natural ecosystems under global anthropogenic climatic changes. This concept makes it possible to carry out local empirical simulation of the regional bioclimatic trend and thereby reveal the mechanisms of transmission of global and regional climate signals to the local level. On the example of the Volga River basin, predictive empirical-statistical models of the carbon balance of forest ecosytems are presented under conditions of a changing climate. The carbon content in various pools of boreal and nemoral forests were calculated. The global climate models give prognostic estimates of the components of them carbon balance. A quantitative assessment of the ecological resources of forest formations that provide the environment sustainability through mechanisms of regulation of the carbon cycle is given. The adaptation of forest ecosystems to climate change is described through the calculated parameters of their functional sustainability.
Mechanisms of Gene Regulation
by Ferdinand Molnár Carsten CarlbergThis textbook aims to describe the fascinating area of eukaryotic gene regulation for graduate students in all areas of the biomedical sciences. Gene expression is essential in shaping the various phenotypes of cells and tissues and as such, regulation of gene expression is a fundamental aspect of nearly all processes in physiology, both in healthy and in diseased states. This pivotal role for the regulation of gene expression makes this textbook essential reading for students of all the biomedical sciences, in order to be better prepared for their specialized disciplines. A complete understanding of transcription factors and the processes that alter their activity is a major goal of modern life science research. The availability of the whole human genome sequence (and that of other eukaryotic genomes) and the consequent development of next-generation sequencing technologies have significantly changed nearly all areas of the biological sciences. For example, the genome-wide location of histone modifications and transcription factor binding sites, such as provided by the ENCODE consortium, has greatly improved our understanding of gene regulation. Therefore, the focus of this book is the description of the post-genome understanding of gene regulation. The purpose of this book is to provide, in a condensed form, an overview on the present understanding of the mechanisms of gene regulation. The authors are not aiming to compete with comprehensive treatises, but rather focus on the essentials. Therefore, the authors have favored a high figure-to-text ratio following the rule stating that "a picture tells more than thousand words". The content of the book is based on the lecture course, which is given by Prof. Carlberg since 2001 at the University of Eastern Finland in Kuopio. The book is subdivided into 4 sections and 13 chapters. Following the Introduction there are three sections, which take a view on gene regulation from the perspective of transcription factors, chromatin and non-coding RNA, respectively. Besides its value as a textbook, Mechanisms of Gene Regulation will be a useful reference for individuals working in biomedical laboratories.
Mechanisms of Gene Regulation: How Science Works
by Carsten Carlberg Ferdinand MolnárThis textbook aims to describe the fascinating area of eukaryotic gene regulation for graduate students in all areas of the biomedical sciences. Gene expression is essential in shaping the various phenotypes of cells and tissues and as such, regulation of gene expression is a fundamental aspect of nearly all processes in physiology, both in healthy and in diseased states. Th is pivotal role for the regulation of gene expression makes this textbook essential reading for students of all the biomedical sciences, in order to be better prepared for their specialized disciplines. A complete understanding of transcription factors and the processes that alter their activity is a major goal of modern life science research. The availability of the whole human genome sequence (and that of other eukaryotic genomes) and the consequent development of next-generation sequencing technologies have significantly changed nearly all areas of the biological sciences. For example, the genome-wide location of histone modifications and transcription factor binding sites, such as provided by the ENCODE consortium, has greatly improved our understanding of gene regulation. Therefore, the focus of this book is the description of the post-genome understanding of gene regulation.
Mechanisms of Genome Protection and Repair (Advances in Experimental Medicine and Biology #1241)
by Dmitry O. ZharkovDNA is under constant challenge from environmental and endogenous metabolic assaults. Several layers of defence and repair systems allow cells to maintain stable genomes; in humans, dysfunction of these systems leads to cancer, neurodegeneration, and other pathologies. At the same time, recently it had emerged that targeted and regulated DNA damage and repair is a mechanism underlying several important cellular processes such as epigenetic demethylation and immunoglobulin gene diversification. The present collection of papers is aimed to cover new developments in the area of protective and regulatory mechanisms associated with DNA damage. The mechanisms ruling the recognition of damaged nucleotides against the vast background of normal ones are reviewed. The role of extended non-catalytic domains that are often found in eukaryotic DNA repair proteins in contrast to their downsized, catalytic-only bacterial counterparts is discussed. Among the proposed subjects are the regulatory functions of bulky covalent modifications such as poly(ADP)ribosylation and ubiquitylation in DNA damage response, especially in the context of chromatin remodelling. As opposed to DNA repair, damage tolerance allows cells to replicate with lesions in the genome; the enzymes responsible are also covered. Finally, we present examples of modern multilevel understanding of the cell function and malfunction in the wake of genotoxic assaults such as oxidative stress, abiotic environmental stress, and DNA-damaging plant toxins.
Mechanisms of Mineralization of Vertebrate Skeletal and Dental Tissues
by Irving M. Shapiro William J. LandisThe book presents a multi-disciplinary approach to understanding mechanisms regulating the formation of mineral in vertebrate skeletal and dental tissues. The focus of the book is directed toward the mineralization process, an evolutionarily conserved system in which cells synthesize a complex and unique extracellular matrix into which mineral is deposited. Regulatory control is viewed though lenses that emphasize the genetic, physical-chemical, biochemical, structural, cellular and extracellular aspects of the mineralization process as they relate to crystal nucleation, growth and maturation. Throughout the book, defects in regulation at the genetic and transcriptional levels are linked to the numerous clinical problems associated with the mineralization of bone, cartilage, tendon, tooth, and soft tissues. The book serves as a comprehensive text for basic scientists and scholars working in the many areas that comprise hard tissue research, as well as undergraduate and graduate students, postdoctoral fellows and those contemplating working in the field of biomineralization or who need a review of a specific mineralization topic. The information contained in the book is relevant for clinicians and clinical scientists in the fields of orthopaedic surgery, veterinary medicine, dentistry, endocrinology, aging and genetics.
Mechanisms of Molecular Carcinogenesis – Volume 1
by Johannes HaybaeckDivided into two volumes the work offers a so far unmatched broad and at the same time deep knowledge on molecular and cellular mechanisms of carcinogenesis and offers comprehensive insight into clinical, therapeutic and technological aspects. This 1st Volume presents tumor entities of the ocular system, the thyroid organ, the oesophagus, gliomas, non-glial brain tumors, head and neck as well as lung cancer. In addition it also discusses in-depth potential novel molecular players and the role of stem cells as well as the endocannabinoid system in carcinogenesis, it furthermore explains tumor metabolism components and signaling pathways. Each of the chapters discusses potential therapeutic strategies and novel drug targets. The book addresses basic scientists and medical researchers interested in translational cancer research.