- Table View
- List View
Modeling Peptide-Protein Interactions
by Ora Schueler-Furman Nir LondonThis volume covers an array of techniques available for studying peptide-protein docking and design. The book is divided into four sections: peptide binding site prediction; peptide-protein docking; prediction and design of peptide binding specificity; and the design of inhibitory peptides. The chapters in Modeling Peptide-Protein Interactions: Methods and Protocols cover topics such as the usage of ACCLUSTER and PeptiMap for peptide binding site prediction; AnchorDock and ATTRACT for blind, flexible docking of peptides to proteins; flexible peptide docking using HADDOCK and FlexPepDock; identifying loop-mediated protein-protein interactions using LoopFinder; and protein-peptide interaction design using PinaColada. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary details for successful application of the different approaches and step-by-step, readily reproducible protocols, as well as tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Modeling Peptide-Protein Interactions: Methods and Protocols provides a diverse and unified overview of this rapidly advancing field of major interest and applicability.
Modeling Phase Transitions in the Brain
by D. Alistair Steyn-Ross Moira Steyn-Ross Walter FreemanForeword by Walter J. Freeman. The induction of unconsciousness using anesthetic agents demonstrates that the cerebral cortex can operate in two very different behavioral modes: alert and responsive vs. unaware and quiescent. But the states of wakefulness and sleep are not single-neuron properties---they emerge as bulk properties of cooperating populations of neurons, with the switchover between states being similar to the physical change of phase observed when water freezes or ice melts. Some brain-state transitions, such as sleep cycling, anesthetic induction, epileptic seizure, are obvious and detected readily with a few EEG electrodes; others, such as the emergence of gamma rhythms during cognition, or the ultra-slow BOLD rhythms of relaxed free-association, are much more subtle. The unifying theme of this book is the notion that all of these bulk changes in brain behavior can be treated as phase transitions between distinct brain states. Modeling Phase Transitions in the Brain contains chapter contributions from leading researchers who apply state-space methods, network models, and biophysically-motivated continuum approaches to investigate a range of neuroscientifically relevant problems that include analysis of nonstationary EEG time-series; network topologies that limit epileptic spreading; saddle--node bifurcations for anesthesia, sleep-cycling, and the wake--sleep switch; prediction of dynamical and noise-induced spatiotemporal instabilities underlying BOLD, alpha-, and gamma-band Hopf oscillations, gap-junction-moderated Turing structures, and Hopf-Turing interactions leading to cortical waves.
Modeling Phosphorus in the Environment
by David E. Radcliffe Miguel L. CabreraDespite advances in modeling, such as graphical user interfaces, the use of GIS layers, and databases for developing input files, the approaches to modeling phosphorus (P) have not changed since their initial development in the 1980s. Current understanding of P processes has evolved and this new information needs to be incorporated into the current
Modeling Populations of Adaptive Individuals (Monographs in Population Biology #63)
by Steven F. Railsback Bret C. HarveyEcologists now recognize that the dynamics of populations, communities, and ecosystems are strongly affected by adaptive individual behaviors. Yet until now, we have lacked effective and flexible methods for modeling such dynamics. Traditional ecological models become impractical with the inclusion of behavior, and the optimization approaches of behavioral ecology cannot be used when future conditions are unpredictable due to feedbacks from the behavior of other individuals. This book provides a comprehensive introduction to state- and prediction-based theory, or SPT, a powerful new approach to modeling trade-off behaviors in contexts such as individual-based population models where feedbacks and variability make optimization impossible.Modeling Populations of Adaptive Individuals features a wealth of examples that range from highly simplified behavior models to complex population models in which individuals make adaptive trade-off decisions about habitat and activity selection in highly heterogeneous environments. Steven Railsback and Bret Harvey explain how SPT builds on key concepts from the state-based dynamic modeling theory of behavioral ecology, and how it combines explicit predictions of future conditions with approximations of a fitness measure to represent how individuals make good—not optimal—decisions that they revise as conditions change. The resulting models are realistic, testable, adaptable, and invaluable for answering fundamental questions in ecology and forecasting ecological outcomes of real-world scenarios.
Modeling Shallow Water Flows Using the Discontinuous Galerkin Method
by Abdul A. Khan Wencong LaiThis book introduces the discontinuous Galerkin (DG) method and its application to shallow water flows. The emphasis is to show details and modifications required to apply the scheme to real-world flow problems. It allows the readers to understand and develop robust and efficient computer simulation models that can be used to model flow, contaminant transport, and other factors in rivers and coastal environments. The book includes a large set of tests to illustrate the use of the model for a wide range of applications.
Modeling Ships and Space Craft
by Gina HaglerModeling Ships and Space Craft: The Science and Art of Mastering the Oceans and Sky begins with the theories of Aristotle and Archimedes, moving on to examine the work of Froude and Taylor, the early aviators and the Wright Brothers, Goddard and the other rocket men, and the computational fluid dynamic models of our time. It examines the ways each used fluid dynamic principles in the design of their vessels. In the process, this book covers the history of hydrodynamic (aero and fluid) theory and its progression - with some very accessible science examples - including seminal theories. Hydrodynamic principles in action are also explored with examples from nature and the works of man. This is a book for anyone interested in the history of technology - specifically the methods and science behind the use of scale models and hydrodynamic principles in the marine and aeronautical designs of today.
Modeling, Simulation and Optimization of Complex Processes - HPSC 2012
by Hans Georg Bock Xuan Phu Hoang Rolf Rannacher Johannes P. SchlöderThis proceedings volume gathers a selection of papers presented at the Fifth International Conference on High Performance Scientific Computing, which took place in Hanoi on March 5-9, 2012. The conference was organized by the Institute of Mathematics of the Vietnam Academy of Science and Technology (VAST), the Interdisciplinary Center for Scientific Computing (IWR) of Heidelberg University, Ho Chi Minh City University of Technology, and the Vietnam Institute for Advanced Study in Mathematics. The contributions cover the broad interdisciplinary spectrum of scientific computing and present recent advances in theory, development of methods, and practical applications. Subjects covered include mathematical modeling; numerical simulation; methods for optimization and control; parallel computing; software development; and applications of scientific computing in physics, mechanics and biomechanics, material science, hydrology, chemistry, biology, biotechnology, medicine, sports, psychology, transport, logistics, communication networks, scheduling, industry, business and finance.
Modeling, Simulation, and Optimization of Supercritical and Subcritical Fluid Extraction Processes
by Zainuddin A. Manan Gholamreza Zahedi Ana Najwa MustapaThis book provides a complete guide on tools and techniques for modeling of supercritical and subcritical fluid extraction (SSFE) processes and phenomena. It provides details for SSFE from managing the experiments to modeling and optimization. It includes the fundamentals of SSFE as well as the necessary experimental techniques to validate the models. The optimization section includes the use of process simulators, conventional optimization techniques and state-of-the-art genetic algorithm methods. Numerous practical examples and case studies on the application of the modeling and optimization techniques on the SSFE processes are also provided. Detailed thermodynamic modeling with and without co-solvent and non equilibrium system modeling is another feature of the book.
Modeling Students' Mathematical Modeling Competencies
by Andrew Hurford Christopher R. Haines Peter L. Galbraith Richard LeshAs we enter the 21st century, there is an urgent need for new approaches to mathematics education emphasizing its relevance in young learners' futures. Modeling Students' Mathematical Modeling Competencies explores the vital trend toward using real-world problems as a basis for teaching mathematics skills, competencies, and applications. Blending theoretical constructs and practical considerations, the book presents papers from the latest conference of the ICTMA, beginning with the basics (Why are models necessary? Where can we find them?) and moving through intricate concepts of how students perceive math, how instructors teach--and how both can become better learners. Dispatches as varied as classroom case studies, analyses of math in engineering work, and an in-depth review of modeling-based curricula in the Netherlands illustrate modeling activities on the job, methods of overcoming math resistance, and the movement toward replicable models and lifelong engagement. A sampling of topics covered: How students recognize the usefulness of mathematicsCreating the modeling-oriented classroomAssessing and evaluating students' modeling capabilitiesThe relationship between modeling and problem-solvingInstructor methods for developing their own models of modelingNew technologies for modeling in the classroomModeling Students' Mathematical Modeling Competencies offers welcome clarity and focus to the international research and professional community in mathematics, science, and engineering education, as well as those involved in the sciences of teaching and learning these subjects.
Modeling, Synthesis and Fracture of Advanced Materials for Industrial and Medical Applications (Advanced Structured Materials #136)
by Sergei M. Aizikovich Holm Altenbach Victor Eremeyev Michael Vincent Swain Alexander GalybinThis book gathers papers presented at the international workshop PMSDAM’19. The respective contributions offer valuable insights for researchers working on numerical solutions to advanced materials problems. The problems concerning the remineralization of teeth are considered. Of particular interest are articles exploring topics at the interface of different disciplines.
Modeling the 3D Conformation of Genomes (Series in Computational Biophysics)
by Guido Tiana Luca GiorgettiThis book provides a timely summary of physical modeling approaches applied to biological datasets that describe conformational properties of chromosomes in the cell nucleus. Chapters explain how to convert raw experimental data into 3D conformations, and how to use models to better understand biophysical mechanisms that control chromosome conformation. The coverage ranges from introductory chapters to modeling aspects related to polymer physics, and data-driven models for genomic domains, the entire human genome, epigenome folding, chromosome structure and dynamics, and predicting 3D genome structure.
Modeling the Electrochemo-poromechanics of Ionic Polymer Metal Composites and Cell Clusters (Springer Theses)
by Alessandro LeronniThis book presents a novel continuum finite deformation framework addressing the complex interactions among electrostatics, species transport, and mechanics in solid networks immersed in a fluid phase of solvent and ions. Grounded on cutting-edge multiphysics theories for soft active materials, the proposed model is primarily applied to ionic polymer metal composites (IPMCs). First, the influence of shear deformation on the IPMC response is analyzed through semi-analytical solutions obtained via the method of matched asymptotic expansions. Second, the novel electrochemo-poromechanical theory is used to predict the curvature relaxation and electric discharge that are observed in IPMC actuation and sensing, respectively, under a sustained stimulus. This newly formulated theory is, in turn, applied to biological cell clusters. Here, important mechanical considerations are integrated into classical bioelectrical models, thus offering novel insights into the interplay of mechanical and electrical signaling in the coordination of developmental processes.
Modeling the Fate of Chemicals in Products (Springer Theses)
by Li LiThis thesis provides a novel methodological basis for mechanistically understanding the dynamics of chemicals in products (CiPs) in the anthroposphere and physical environment and establishes a modeling continuum from production of a chemical to its concentrations in various environmental compartments. Using this framework, the thesis investigates how CiPs are transported and transformed and how they accumulate in the global environment. Furthermore, it identifies the measures needed to minimize their adverse effects on the environment and human society. It serves as an invaluable, interdisciplinary reference resource for industrial ecologists, environmental chemists and decision-makers involved in environmentally sound management of CiPs and associated waste.
Modeling the Health Risks of Climate Change: Workshop Summary
by Kellyn BettsClimate change poses risks to human health and well-being through shifting weather patterns, increases in frequency and intensity of heat waves and other extreme weather events, rising sea levels, ocean acidification, and other environmental effects. Those risks occur against a backdrop of changing socioeconomic conditions, medical technology, population demographics, environmental conditions, and other factors that are important in determining health. Models of health risks that reflect how health determinants and climate changes vary in time and space are needed so that we can inform adaptation efforts and reduce or prevent adverse health effects. Robust health risk models could also help to inform national and international discussions about climate policies and the economic consequences of action and inaction. Interest in resolving some of the challenges facing health effects modelers and health scientists led the National Research Council's Standing Committee on Emerging Science for Environmental Health Decisions to hold a workshop on November 3-4, 2014, in Washington, DC, to explore new approaches to modeling the human health risks of climate change. Throughout the workshop, the discussions highlighted examples of current application of models, research gaps, lessons learned, and potential next steps to improve modeling of health risks associated with climate change. "Modeling the Health Risks of Climate Change" summarizes the presentation and discussion of the workshop.
Modeling the Interplay Between Human Behavior and the Spread of Infectious Diseases
by Alberto D'Onofrio Piero ManfrediThis volume summarizes the state-of-the-art in the fast growing research area of modeling the influence of information-driven human behavior on the spread and control of infectious diseases. In particular, it features the two main and inter-related "core" topics: behavioral changes in response to global threats, for example, pandemic influenza, and the pseudo-rational opposition to vaccines. In order to make realistic predictions, modelers need to go beyond classical mathematical epidemiology to take these dynamic effects into account. With contributions from experts in this field, the book fills a void in the literature. It goes beyond classical texts, yet preserves the rationale of many of them by sticking to the underlying biology without compromising on scientific rigor. Epidemiologists, theoretical biologists, biophysicists, applied mathematicians, and PhD students will benefit from this book. However, it is also written for Public Health professionals interested in understanding models, and to advanced undergraduate students, since it only requires a working knowledge of mathematical epidemiology.
Modeling Thermodynamic Distance, Curvature and Fluctuations
by Viorel BadescuThis textbook aimsto briefly outline the main directions in which the geometrization ofthermodynamics has been developed in the last decades. The textbook isaccessible to people trained in thermal sciences but not necessarily withsolid formation in mathematics. For this, in the first chapters a summary of themain mathematical concepts is made. In some sense, this makes thetextbook self-consistent. The rest of the textbook consists of a collection ofresults previously obtained in this young branch of thermodynamics. The manner ofpresentation used throughout the textbook is adapted for ease ofaccess of readers with education in natural and technical sciences.
Modeling Tools for Environmental Engineers and Scientists
by Nirmala KhandanModeling Tools for Environmental Engineers and Scientists enables environmental professionals, faculty, and students with minimal computer programming skills to develop computer-based mathematical models for natural and engineered environmental systems. The author illustrates how commercially available syntax-free authoring software can be adapted
Modeling Transcriptional Regulation: Methods and Protocols (Methods in Molecular Biology #2328)
by Shahid MukhtarThis book provides methods and techniques used in construction of global transcriptional regulatory networks in diverse systems, various layers of gene regulation and mathematical as well as computational modeling of transcriptional gene regulation. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Modeling Transcriptional Regulation: Methods and Protocols aims to provide an in depth understanding of new techniques in transcriptional gene regulation for specialized audience.
Modeling Uncertainty in the Earth Sciences
by Jef CaersModeling Uncertainty in the Earth Sciences highlights the various issues, techniques and practical modeling tools available for modeling the uncertainty of complex Earth systems and the impact that it has on practical situations. The aim of the book is to provide an introductory overview which covers a broad range of tried-and-tested tools. Descriptions of concepts, philosophies, challenges, methodologies and workflows give the reader an understanding of the best way to make decisions under uncertainty for Earth Science problems.The book covers key issues such as: Spatial and time aspect; large complexity and dimensionality; computation power; costs of 'engineering' the Earth; uncertainty in the modeling and decision process. Focusing on reliable and practical methods this book provides an invaluable primer for the complex area of decision making with uncertainty in the Earth Sciences.
Modeling US Armor of World War 2
by Steven J. ZalogaUnited States tanks and other armored fighting vehicles in World War II have always been some of the most popular subjects for scale modelers, and hundreds of kits have been and are currently manufactured. Now, renowned modeler and AFV expert, Steven J. Zaloga, presents the definitive guide to modeling these famous fighting vehicles. Based around four building projects, Zaloga presents all the techniques necessary to get a great finish on a model, including super-detailing, correcting a flawed kit, building a resin model, scratch building, and painting and markings. These step-by-step guides is enhanced by numerous photographs specially shot form Steven's personal collection of US WWII armor, which looks at the vehicles with a modeler's eye and aid in obtaining the most realistic results on a finished project.
Modeling Waves with Numerical Calculations Using Python (Synthesis Lectures on Wave Phenomena in the Physical Sciences)
by Rhett AllainNumerical calculations (what many call computational physics) is a core tool in modern physics. With numerical methods it’s possible to solve problems that would otherwise be impossible. Most physics students and educators have at least some exposure to the wave equation. It shows up in many different contexts—light, quantum mechanics, and even a simple wave on a string. However, it can be difficult to come up with non-trivial solutions to the wave equation. This text goes through the techniques to create a numerical model of the wave equation starting from the very basics and using free and open source tools such as Python and Web VPython.
Modellierung von Wasserrisiken: Entwicklung von Techniken zur Risiko-Rendite-Steuerung in der Finanzwelt und darüber hinaus
by Dieter Gramlich Thomas Walker Maya Michaeli Charlotte Esme FrankDieses Buch beleuchtet das Thema finanzielles Wasserrisiko, indem es die Modellierungs-Herausforderungen untersucht, die mit physischem, regulatorischem und Ruf-bedingtem Wasserrisiko in der Finanzwelt verbunden sind. Es erkundet verschiedene Ansätze zur Operationalisierung von Wasserrisiken aus finanzieller Analyse, Investmentmanagement und Klimawissenschaft. Die Analyse von Instrumenten zur Bewertung von Wasserrisiken bildet die Grundlage für die Entwicklung geeigneter Risiko-Rendite-Steuerungstechniken in der Finanzbranche und darüber hinaus. Dieses Buch liefert neue Einblicke, indem es sich auf finanzielle Wassergefahren und die damit verbundenen Chancen konzentriert. Es wird sowohl für Wissenschaftler als auch Praktiker von Interesse sein, die an der Schnittstelle von Finanzen, Wirtschaft, Natur und Gesellschaft tätig sind.
Modellierungsverfahren für die Konzeption von komplexen Systemen in der Fernsehproduktion: Operationalisierung des Systems Engineering für die digitale Transformation im Fernsehen
by Christiane JanuschDie Herstellungsprozesse in der Fernsehproduktion sind von einer unüberschaubaren Anzahl unterschiedlicher Varianten geprägt. Verschiedene Produktionsformen, wie beispielsweise die Aktualität, Live-Events oder Fiktionales Programm, erfordern ein vielfältiges Zusammenspiel der Funktionsbereiche eines Fernsehproduktionsunternehmens. Für die Optimierung der Herstellungsprozesse müssen redaktionell steuernde, administrativ begleitende und technisch ausführende Prozesse in übergreifend vernetzten, integrierten Produktionssystemen eng miteinander verknüpft werden. Vor dem Hintergrund dieser Komplexität bedarf es einer Gesamtsicht auf alle an der Produktion beteiligten Funktionsbereiche und deren Einbindung in den Herstellungsprozess. Es wird ein umfassendes Modellierungsverfahren vorgestellt, das in der Lage ist, sowohl die Gesamtbetrachtung zu fördern als auch Detailbetrachtungen vorzunehmen. Darüber hinaus wird die Anwendung der Methodik anhand von Praxisbeispielen erläutert. Es ist ein Vorschlag, den wissenschaftlichen Ansatz des Systems Engineering im Hinblick auf Problemstellungen in der Fernsehproduktion zu operationalisieren und den kontinuierlichen Optimierungsprozess zu unterstützen.
Modelling, Analysis, and Control of Networked Dynamical Systems (Systems & Control: Foundations & Applications)
by Ziyang Meng Tao Yang Karl H. JohanssonThis monograph provides a comprehensive exploration of new tools for modelling, analysis, and control of networked dynamical systems. Expanding on the authors’ previous work, this volume highlights how local exchange of information and cooperation among neighboring agents can lead to emergent global behaviors in a given networked dynamical system.Divided into four sections, the first part of the book begins with some preliminaries and the general networked dynamical model that is used throughout the rest of the book. The second part focuses on synchronization of networked dynamical systems, synchronization with non-expansive dynamics, periodic solutions of networked dynamical systems, and modulus consensus of cooperative-antagonistic networks. In the third section, the authors solve control problems with input constraint, large delays, and heterogeneous dynamics. The final section of the book is devoted to applications, studying control problems of spacecraft formation flying, multi-robot rendezvous, and energy resource coordination of power networks.Modelling, Analysis, and Control of Networked Dynamical Systems will appeal to researchers and graduate students interested in control theory and its applications, particularly those working in networked control systems, multi-agent systems, and cyber-physical systems. This volume can also be used in advanced undergraduate and graduate courses on networked control systems and multi-agent systems.
Modelling and Advanced Earth Observation Technologies for Coastal Zone Management (Springer Remote Sensing/Photogrammetry)
by Elham Mahmoud Ali Islam Abou El-MagdThis volume provides readers with the tools to unlock the potential of Earth observation (EO) technologies to transform coastal zone management. This comprehensive guide delves into how EO technologies can be used monitor and manage coastal areas, emphasizing sustainable land use and development. Designed for researchers, decision-makers, and environmental planners, this book offers multi-scale assessment approaches that provide actionable solutions and strategic plans for managing extensive environmental landscapes. Readers will discover innovative management solutions for a variety of environmental challenges, along with new methodologies aimed at sustainable development and the achievement of the United Nations Sustainable Development Goals (SDGs) and 2030 targets. This volume showcases numerous multi-tasked applications of satellite data from diverse sources, validating the immense value of earth observations in environmental management. By integrating this data into geographical databases, the book provide an ideal framework for spatial planning at various scales. Geospatial information is a crucial tool for creating interactive systems for spatial analysis, merging real-world data with forecasting models to support social and economic development. Geospatial information guides where and when to act, aiding in the development of strategic and implementation plans that promote sustainable development. Embrace the future of coastal zone management with this volume and equip yourself with the knowledge and tools to make informed, impactful decisions for a sustainable tomorrow.