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Molecular Genetics of Endometrial Carcinoma
by Lora Hedrick EllensonThis comprehensive text provides a much-needed review of a disease that is currently garnering the interest of molecular biologists, translational scientists, and clinicians. The volume includes emerging developments in the molecular genetics of endometrial carcinoma. In addition to covering the basic mechanisms of endometrial carcinoma, chapters also cover a wide range of signaling pathways implicated in endometrial carcinoma. A section of the book includes a number of genetically engineered mouse models, which lead to understanding the role of various genetic alterations in the development and progression of endometrial carcinoma. These models also provide preclinical models for developing effective targeted therapeutic approaches. Endometrial carcinoma is the most common malignancy of the female genital tract in the United States and a malignancy that is growing around the world. However, the molecular genetics of this complex disease have remained poorly understood, since there is no current, comprehensive volume on the topic. This book is a primarily resource for a wide range of scientists, including basic signal transduction biologists, as well as to those interested in developing targeted therapeutics for endometrial carcinoma.
Molecular Genetics of Inflammatory Bowel Disease
by Mauro D'Amato John D RiouxResearch in Crohn's disease (CD) and ulcerative colitis (UC), together known as the inflammatory bowel diseases (IBD), has truly seen a revolution in the last 5-10 years. This book examines how these genetic discoveries have led to the identification of biological functions not previously associated with IBD pathophysiology (e. g. autophagy), how multiple genetic risk factors for IBD converge on given biological functions and that together the identified variants in these genes have predisposing and protective roles (e. g. the multiple variants in the receptor for the IL23 cytokine and its signaling cascade), and how having such a large number of known genetic risk factors has changed our understanding not only about the genetic and molecular overlap between CD and UC, but also between these diseases and other chronic inflammatory diseases (e. g. psoriasis, multiple sclerosis, type 1 diabetes and many others).
Molecular Genetics of Inflammatory Bowel Disease
by Charlotte Hedin John D. Rioux Mauro D’AmatoThis book reaches out to a wide variety of professionals in the biomedical field with an interest in inflammatory bowel disease (IBD). Enormous progress has been made in the last few years since the publication of the first edition in the study of complex diseases and IBD, with hundreds of genomic regions identified that are associated with increased risk. Authored by leading clinical and research scientists in the field, the book includes state-of-the art synopses of recent genetic findings, and their interpretation for current and future exploitation in translational approaches to personalized medicine in IBD. The book also covers risk prediction, improved diagnostic and therapeutic precision, dissection of disease phenotypes and subtypes, identification of biomarkers, and host gene-microbiota interactions of clinical relevance.
Molecular Genetics of Mycobacteria (ASM Books #42)
by Hatfull Graham WilliamA comprehensive collection of perspectives by experts in mycobacterial molecular biology Mycobacterium tuberculosis causes one in four avoidable deaths in the developing world and kills more adults than malaria, AIDS, and all tropical diseases combined. Tuberculosis was named a global health emergency by the World Health Organization, a distinction no other disease has received. Although the study of mycobacterial genetics has expanded dramatically, with new investigations into mycobacterial growth, replication, metabolism, physiology, drug susceptibility, and virulence, most of the problems in tuberculosis control that existed in 2000 remain today. Advances in our understanding of mycobacterial genetics have been reflected in exciting recent developments. New diagnostic approaches can identify drug resistance within a few hours, promising new drugs are progressing through the pipeline and into the clinic, and a range of newly developed vaccines are being evaluated. It is an exciting time as the fruits of 30 years of intensive genetic investigation are finally beginning to emerge. Written by leading experts in the field, Molecular Genetics of Mycobacteria, Second Edition, Discusses key areas of current research in mycobacterial genetics Explains the genetics of the physiology, metabolism, and drug sensitivities of M. tuberculosis Presents genetic approaches for manipulating M. tuberculosis This book is an invaluable resource for anyone interested in the molecular genetics and molecular biology of mycobacteria.
Molecular Genetics of Pancreatic Cancer
by Diane M. Simeone Anirban MaitraPancreatic cancer is a formidable disease, and advances in early detection and improved therapeutics have been slow to come forth. With new advances in molecular genetics in the field of pancreatic tumorigenesis, it is an opportune time to use these recent discoveries to enhance our understanding of pancreatic cancer biology and to improve outcomes in patients. In this volume, leading experts in the field shed light on these findings describing the mutational landscape of pancreatic cancer, including new inroads into our understanding of familial pancreatic cancer, epidemiology, the biology of K-ras signaling, and the emerging contribution of epigenetic alterations to disease initiation and progression. The distinctive pancreatic cancer-stroma ecosystem as determined by the dynamic interplay of inflammation, hallmark mutations, EMT, and cancer stem cells is described, and implications of these interactions in the context of development of novel, personalized therapeutic options are explored.
Molecular Genetics of Pediatric Orthopaedic Disorders
by Carol A. Wise Jonathan J. RiosIn the past two decades we have seen a surge forward in understanding the genetics and biochemistry underlying many pediatric orthopaedic disorders. A few projects have even progressed into the realm of clinical trials that are primarily aimed at controlling progressive disease. Meanwhile, genomic technology development has outpaced expectations and is enabling gene discovery for disorders that were previously intractable with traditional genetic methods. Included in this latter category are common disorders that display multigenic inheritance, sporadic disorders, and very rare conditions that are difficult to ascertain. Simultaneously, the study of pediatric orthopaedic disorders has been continuously refined and updated, highlighting a number of likely genetic conditions that are as yet unsolved. Molecular Genetics of Pediatric Orthopaedic Disorders updates researchers and clinicians of new developments of pediatric orthopaedic genetics. The chapters inform the audience on the revolution in new genomic methods and the impact this is having on potential study designs and the potential to discover genetic causes of many unsolved orthopaedic conditions. Recent examples have been included of pediatric orthopaedic conditions, both rare and common, that are being solved with these new methods. The book also educates pediatric orthopedic clinicians and geneticists on our understanding of the biology of "classic" genetic diseases that were derived from prior genetic studies. Chapters include biobanks and strategies for studying very rare disorders, genes and pathways causing primordial dwarfism, and notch signaling in congenital scoliosis, and more.
Molecular Geometry of Body Pattern in Birds
by Antonio Lima-de-FariaAfter having read this book you will never see birds in the same way again. The unexpected patterns displayed by a bird's body have been seen as bizarre events that demanded little attention or were described as 'amazing curiosities'. None of these surprising features seem to be fortuitous. They appear to be an integral part of a rigid order and a coherent geometry, which is directed by simple gene interactions and molecular cascades occurring at various cellular levels, and at different times, during the organism's development. A novel geometry unfolds in front of your eyes, giving the body configurations another meaning. Lima-de-Faria is Professor Emeritus of Molecular Cytogenetics at Lund University, Lund, Sweden. This is his sixth book dealing with the molecular organization of the chromosome and its implications for the understanding of the mechanisms responsible for biological evolution.
Molecular Hematology
by Drew Provan Hillard M. LazarusProvides a core knowledgebase for those with minimal exposure to hematologic molecular biology, fully revised and updated Molecular Hematology brings together the most up-to-date and reliable information on the molecular basis of major hematologic diseases. Edited and authored by leading experts in the field, this volume demonstrates the clinical relevance of molecular biology in the diagnosis and treatment of blood disorders. Concise, accessible chapters address key topics in modern hematology, such as lymphoma genetics, molecular coagulation, thrombophilia, pharmacogenomics, platelet disorders, hemophilia, anemia, and multiple myeloma. Chapters introduce and summarize specific hematologic diseases, explore the pathogenesis of the disorder, highlight new and emerging molecular strategies, and more. Now in its fifth edition, Molecular Hematology is fully revised to incorporate contemporary hematology research and practice. Entirely new chapters cover topics such as CAR-T cell technology, COVID, cancer cell biology, gene therapy and gene editing in clinical practice, as well as the impact of molecular research on the diagnosis and treatment of various malignant hematologic diseases. This edition includes updated suggested readings and a wealth of new full-color charts, graphs, and illustrations throughout. Covers the molecular biology of different blood diseases, their pathogeneses, and current molecular research and therapies Illustrates the impact of molecular research on hematologic investigations and therapeutics Discusses how progress in basic science and therapeutics has improved the diagnosis and care of patients with various hematologic disorders Surveys recent developments in cancer-cell biology, with an emphasis on leukemia and lymphoma Includes access to a companion Digital Edition providing search across the book, downloadable illustrations, and notation tools Molecular Hematology is a must-have resource for established and trainee clinicians, clinical scientists and researchers, medical students, and upper-level undergraduates in the fields of hematology, oncology, and molecular biology.
Molecular Histopathology and Tissue Biomarkers in Drug and Diagnostic Development
by Steven J. Potts David A. Eberhard Keith A. WhartonMolecular Histopathology and Tissue Biomarkers in Drug and Diagnostic Development gathers diverse experts to present state of the art guidance and application of histopathology in drug development settings ranging from discovery research to human clinical trials. While many current applications of quantitative histology and molecular pathology in the biopharmaceutical industry are focused on oncology, this volume in addition explores non-oncologic disease areas including nonalcoholic steatohepatitis, arthritis, celiac disease, myeloproliferative disorders, neurology, and wound healing. The authors write from years of experience in diagnostic practice and pharmaceutical drug development, aiming to educate pharmaceutical and academic scientists how to best use tissue to diagnose disease and improve the process of drug development. As part of the Methods in Pharmacology and Toxicology series, this volume is designed to provide wisdom and examples that others can follow and apply as part of drug development. Comprehensive and practical, Molecular Histopathology and Tissue Biomarkers in Drug and Diagnostic Development will inform and enlighten both tissue-focused and non-tissue-focused drug development professionals about better use and interpretation of the multidimensional data contained in a tissue biopsy.
Molecular Host Plant Resistance to Pests (Books In Soils, Plants, And Environment Ser. #Vol. 96)
by S. Sadasivam B. ThayumanavanMolecular Host Plant Resistance to Pests examines environmentally safe and integrated techniques for effective pest management. Offering more than 1500 references for further exploration of the topic, this reference details the bioactivity, biosynthetic pathways, mechanisms of action, and genetic regulation for improved methods of crop protection a
Molecular Hydrogen for Medicine: The Art of Ancient Life Revived
by Yuh FukaiThis book provides a comprehensive account of the current status of molecular hydrogen medicine, a young field that emerged with the discovery that inhalation of hydrogen gas leads to the elimination of harmful reactive oxygen species in rats. Various physiologic effects have since been demonstrated, and possible medical applications identified. Numerous clinical projects have now been undertaken, yielding startling results. Despite this, molecular hydrogen medicine remains underappreciated among the medical community at large. The author aims to rectify this situation by fairly but critically evaluating the potential clinical benefits based on the latest scientific research. In addition, the observed physiological effects of hydrogen gas are considered within the broad context of the evolution of life on earth, offering new perspectives and helping to place molecular hydrogen medicine legitimately within the framework of life sciences. Written in an accessible manner, the book will be of value to students, researchers, clinicians, and the general public.
Molecular Hydrogen in Health and Disease (Advances in Biochemistry in Health and Disease #27)
by Jan Slezak Branislav KuraMolecular hydrogen (H2) has emerged as a promising therapeutic and preventive medical gas. Hydrogen gas has garnered significant attention in recent years due to its remarkable antioxidant and anti-inflammatory properties. H2 exhibits exceptional pharmacokinetics, swiftly traversing cellular biomembranes to access subcellular organelles indirectly regulating hormones and cytokines through various signal transduction pathways. H2 has the potential to address a wide range of issues, including clinical medical treatment in the areas of healthcare: myocardial ischemia, heart failure, cardiac arrest, metabolic syndrome, advanced-stage cancer, inflammatory diseases, Alzheimer's dementia, aging-related disorders, sports activities, and even beauty, agriculture, etc.Selected world-known authors in the field provide readers with a comprehensive overview of molecular hydrogen's remarkable effects and its physical, chemical, and therapeutic properties and potential in biomedical applications. This contributed volume fills the current gap in information and is intended for everyone who wants to be better informed about the wide possibilities of using molecular hydrogen. However, it is mainly intended for use by medical students, physiologists, pharmacologists, physicians, and other healthcare personnel who can use molecular hydrogen to improve the health of everyone who needs it.
Molecular Identification of Fungi
by Youssuf Gherbawy Kerstin VoigtFungi enjoy great popularity in pharmaceutical, agricultural, and biotechnological applications. Recent advances in the decipherment of whole fungal genomes promise an acceleration of these trends. This timely book links scientists from different parts of the world who are interested in the molecular identification of fungi combined with the exploration of the fungal biodiversity in different ecosystems. It provides a compendium for scientists who rely on a rapid and reliable detection of fungal specimens in environmental as well as clinical resources in order to ensure the benefit of industrial and clinical applications. Chapters focus on the opportunities and limits of the molecular marker-mediated identification of fungi. Various methods, procedures and strategies are outlined. Furthermore, the book offers an update of the current progress in the development of fungal molecular techniques, and draws attention to potential and associated problems, as well as integrating theory and practice.
Molecular Identification of Mosquito Vectors and Their Management
by Tapan Kumar BarikThis book summarizes the recent advancements in identifying the mosquito vectors and discusses various strategies for their control. The book describes various molecular taxonomic methods, including DNA barcoding and single nucleotide polymorphism-based machine learning approach, which are used for the identification of mosquito vectors. It also presents the various mosquito control methods, namely, phytochemicals, Bacillus thuringiensis toxins, nanotechnology, biological control agents, and environmental management strategies. It also highlights the importance of various repellents that are used for protection from different kinds of mosquito vectors. Finally, the book offers a comprehensive yet representative description of challenges associated with mosquito vector-borne diseases. The book is a useful resource for medical entomologists, health workers, and researchers working in mosquito-control and vector-borne diseases.
Molecular Imaging
by Khalid ShahIn recent years, molecular imaging techniques have grown to be invaluable tools for molecular biology research and, to a more modest extent, clinical medicine. In Molecular Imaging: Methods and Protocols, expert researchers explore the latest advances in the field, describing a rich variety of practical procedures and methods for diverging imaging technologies. Chapters are divided into sections that cover the imaging of basic molecular and biochemical events, imaging in pre-clinical settings, and imaging in clinical settings. Composed in the highly successful Methods in Molecular BiologyTM series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls. Comprehensive and ground-breaking, Molecular Imaging: Methods and Protocols is an essential handbook for students, established practitioners, and research fellows alike.
Molecular Imaging in Oncology
by Burkhard Riemann Otmar SchoberThe impact of molecular imaging on diagnostics, therapy, and follow-up in oncology is increasing steadily. Many innovative molecular imaging probes have already entered clinical practice, and there is no doubt that the future emphasis will be on multimodality imaging in which morphological, functional, and molecular imaging techniques are combined in a single clinical investigation. This handbook addresses all aspects of molecular imaging in oncology, from basic research to clinical applications. The first section is devoted to technology and probe design, and examines a variety of PET and SPECT tracers as well as multimodality probes. Preclinical studies are then discussed in detail, with particular attention to multimodality imaging. In the third section, diverse clinical applications are presented, and the book closes by looking at future challenges. This handbook will be of value to all who are interested in the revolution in diagnostic oncology that is being brought about by molecular imaging.
Molecular Imaging of Small Animals
by Habib ZaidiThis book examines the fundamental concepts of multimodality small-animal molecular imaging technologies and their numerous applications in biomedical research. Driven primarily by the widespread availability of various small-animal models of human diseases replicating accurately biological and biochemical processes in vivo, this is a relatively new yet rapidly expanding field that has excellent potential to become a powerful tool in biomedical research and drug development. In addition to being a powerful clinical tool, a number of imaging modalities including but not limited to CT, MRI, SPECT and PET are also used in small laboratory animal research to visualize and track certain molecular processes associated with diseases such as cancer, heart disease and neurological disorders in living small animal models of disease. In vivo small-animal imaging is playing a pivotal role in the scientific research paradigm enabling to understand human molecular biology and pathophysiology using, for instance, genetically engineered mice with spontaneous diseases that closely mimic human diseases.
Molecular Imaging of the Brain
by M. M. Kaila Rakhi KailaThis book examines multi-quantum magnetic resonance imaging methods and the diagnostics of brain disorders. It consists of two Parts. The part I is initially devoted towards the basic concepts of the conventional single quantum MRI techniques. It is supplemented by the basic knowledge required to understand multi-quantum MRI. Practical illustrations are included both on recent developments in conventional MRI and the MQ-MRI. This is to illustrate the connection between theoretical concepts and their scope in the clinical applications. The Part II initially sets out the basic details about quadrupole charge distribution present in certain nuclei and their importance about the functions they perform in our brain. Some simplified final mathematical expressions are included to illustrate facts about the basic concepts of the quantum level interactions between magnetic dipole and the electric quadrupole behavior of useful nuclei present in the brain. Selected practical illustrations, from research and clinical practices are included to illustrate the newly emerging ideas and techniques. The reader should note that the two parts of the book are written with no interdependence. One can read them quite independently.
Molecular Imaging with Reporter Genes
by Sanjiv Sam Gambhir Shahriar S. YaghoubiReporter genes have been used for several decades to study regulation of gene expression in vivo. However, it was little more than a decade ago that a new class of reporter genes was developed for imaging molecular events within living subjects. By following the interactions of protein molecules, researchers can resolve the complex chemical pathways that living cells utilise. This book focuses on this group of imaging reporter genes, starting with detailed descriptions of all reporter genes from different imaging modalities, including optical, MRI, and radionuclide-based imaging. Key scientists in the field explain how to enhance reporter gene imaging utility through instrumentation and the various applications of this technology. This is the first comprehensive book on all aspects of reporter gene imaging, detailing what is known in the field and future goals for research. Investigators in biomedical sciences, physicians, and the biotechnology and pharmaceutical industries will benefit from topics covered.
The Molecular Immunology of Complex Carbohydrates-3
by Albert M. WuBased on the third symposium on "Molecular Immunology of Complex Carbohydrates," this text covers the latest in glycotopes, structures and functions of complex carbohydrates, recognition factors of lectins, biomolecular interactions and other glycosciences. This volume highlights the informative events of the Symposium on Molecular Immunology of Complex Carbohydrates III, held at the Institute of Biological Chemistry, Academia Sinica, on July 15-20, 2007, in Taipei, Taiwan.
Molecular Immunotoxicology
by Emanuela Corsini Henk Van LoverenThe first comprehensive reference on immunotoxicology using analyses based on molecular effects rather than on animal models. Following an introduction to immune system pathways and toxicity mechanisms from a systemic perspective, the main part of the book surveys individual molecular mechanisms of important immunotoxicants, from PAHs to biopharmaceuticals, and from receptor-mediated toxicity to nanoparticle toxicity. Taken together, the knowledge presented here provides an up-to-date overview of this hot topic that can be directly applied to the prediction and characterization of immunotoxic effects in drugs, chemicals, and environmental contaminants.
Molecular Imprinting
by Karsten HauptMolecularly Imprinted Polymers, by Karsten Haupt, Ana V. Linares, Marc Bompart und Bernadette Tse Sum Bui.- Physical Forms of MIPs, by Andrea Biffis, Gita Dvorakova und Aude Falcimaigne-Cordin.- Micro and Nanofabrication of Molecularly Imprinted Polymers, by Marc Bompart, Karsten Haupt und Cédric Ayela.- Immuno-Like Assays and Biomimetic Microchips, by M. C. Moreno-Bondi, M. E. Benito-Peña, J. L. Urraca und G. Orellana.- Chemosensors Based on Molecularly Imprinted Polymers, by Subramanian Suriyanarayanan, Piotr J. Cywinski, Artur J. Moro, Gerhard J. Mohr und Wlodzimierz Kutner.- Chromatography, Solid-Phase Extraction, and Capillary Electrochromatography with MIPs, by Blanka Tóth und George Horvai.- Microgels and Nanogels with Catalytic Activity, by M. Resmini, K. Flavin und D. Carboni.
Molecular Imprinting of Polymers
by Sergey PiletskyOne of Nature's most important talents is evolutionary development of systems capable of molecular recognition: distinguishing one molecule from another. Molecular recognition is the basis for most biological processes, such as ligandreceptor binding, substrate-enzyme reactions and translation and transcription of the genetic code and is therefore
Molecular Industrial Mycology: Systems and Applications for Filamentous Fungi (Mycology Ser. #8)
by LeongTen articles provide an overview of the recently flowering research into the genetics and molecular biology of fungus species that are economically significant in industry. The contributors, from a variety of disciplines, report on work in such areas as industrial enzymes, antibiotics, toxins, heter
Molecular Interactions: Concepts and Methods
by David A. MichaA modern, comprehensive text and reference describing intermolecular forces, this book begins with coverage of the concepts and methods for simpler systems, then moves on to more advanced subjects for complex systems – emphasizing concepts and methods used in calculations with realistic models and compared with empirical data. Contains applications to many physical systems and worked examples Proceeds from introductory material to advanced modern treatments Has relevance for new materials, biological phenomena, and energy and fuels production