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Nuclear Terrorism and National Preparedness
by Samuel Apikyan David DiamondThe nuclear crisis in Fukushima and growing threats of nuclear terrorism must serve as a wake-up call, prompting greater action to prepare ourselves for nuclear and radiological disasters. Our strategy to prepare for these threats is multi-layered and the events of these past years have proved the necessity to re-evaluate the national and international preparedness goals on a scale never before considered. The programme of NATO Advanced Research Workshop on "Preparedness for Nuclear and Radiological Threats" has been focused on science and technology challenges associated with our need to improve the national and international capacity and capability to prevent, protect against, mitigate the effects of, respond to, and recover from the nuclear and radiological disasters, including nuclear and radiological accident, terrorist attack by Improvised Nuclear Device (IND) or by "Dirty Bomb"-Radiological Dispersal Device (RDD), that pose the greatest risk to the national and international security and safety.
Nuclear Test Ban
by S. Mykkeltveit Hein HaakThe book gives a broad presentation in laymen's language of the creation and the implementation of the treaty prohibiting nuclear test explosions (Comprehensive Nuclear-Test-Ban Treaty: CTBT), one of the key guarantors of nuclear non-proliferation. The writers, who personally guided this work for more than 25 years, give a unique insight into the challenging international work to establish a complex technological system with global coverage in a political environment. Extensive nuclear testing has occurred and this is comprehensively reviewed, as are the arguments in favour of a test ban and efforts to implement one. The Conference on Disarmament in Geneva witnessed unprecedented efforts by scientists from around the world to form a common understanding of how to verify a test ban treaty and develop a prototype global verification system; work that was significant in building confidence at the height of the Cold War. The political negotiations and the Treaty itself are briefly analysed, but the main part of the book is devoted to more than a decade of effort by the Preparatory Commission for the CTBT Organization to implement the Treaty and its verification system: the most comprehensive verification system ever created, with a global coverage connecting more than 300 monitoring stations and including an intrusive on-site inspection regime. The first, most promising test results are also presented. An essential element of the book is its assessment of the experience gained through many years of political, managerial and technical activity. Such lessons, if well learned, can benefit the negotiations of future international treaties where verification is crucial, such as in arms control, disarmament or the environment.
Nuclear Theory in the Age of Multimessenger Astronomy
by Omar Benhar Alessandro Lovato Andrea Maselli Francesco PannaraleOver the last decade, astrophysical observations of neutron stars — both as isolated and binary sources — have paved the way for a deeper understanding of the structure and dynamics of matter beyond nuclear saturation density. The mapping between astrophysical observations and models of dense matter based on microscopic dynamics has been poorly investigated so far. However, the increased accuracy of present and forthcoming observations may be instrumental in resolving the degeneracy between the predictions of different equations of state. Astrophysical and laboratory probes have the potential to paint to a new coherent picture of nuclear matter — and, more generally, strong interactions — over the widest range of densities occurring in the Universe. This book provides a self-contained account of neutron star properties, microscopic nuclear dynamics and the recent observational developments in multimessenger astronomy. It also discusses the unprecedented possibilities to shed light on long standing and fundamental issues, such as the validity of the description of matter in terms of pointlike baryons and leptons and the appearance of deconfined quarks in the high density regime.It will be of interest to researchers and advanced PhD students working in the fields of Astrophysics, Gravitational Physics, Nuclear Physics and Particle Physics.Key Features: Reviews state-of-the-art theoretical and experimental developments Self-contained and cross-disciplinary While being devoted to a very lively and fast developing field, the book fundamentally addresses methodological issues. Therefore, it will not be subject to fast obsolescence. Omar Benhar is an INFN Emeritus Research Director, and has been teaching Relativistic Quantum Mechanics, Quantum Electrodynamics and Structure of Compact Stars at “Sapienza” University of Rome for over twenty years. He has worked extensively in the United States, and since 2013 has served as an adjunct professor at the Center for Neutrino Physics of Virginia Polytechnic Institute and State University. Prof. Benhar has authored or co-authored three textbooks on Relativistic Quantum Mechanics, Gauge Theories, and Structure and Dynamics of Compact Stars, and published more than one hundred scientific papers on the theory of many-particle systems, the structure of compact stars and the electroweak interactions of nuclei.Alessandro Lovato is a physicist at Argonne National Laboratory and an INFN researcher in Trento. His research in theoretical nuclear physics focuses on consistently modeling the self-emerging properties of atomic nuclei and neutron-star matter in terms of the microscopic interactions among the constituent protons and neutrons. He has co-authored more than eighty scientific publications on the theory of many-particle systems, the structure of compact stars, and the electroweak interactions of nuclei. He is at the forefront of high-performance computing applied to solving the quantum many-body problem.Andrea Maselli is an Associate Professor at the Gran Sasso Science Institute, in L’Aquila, where he teaches Gravitation and Cosmology and Physics of Black Hole. His research focuses on strong gravity, which plays a crucial role in many astrophysical phenomena involving black hole and neutron stars, representing natural laboratories to test fundamental physics. Prof. Maselli has co-authored more than eighty scientific papers on the modelling of black holes and neutron stars in General Relativity and extension thereof, their gravitational wave emission, and on tests of gravity in the strong filed regime. He is active in various collaborations aimed at developing next generation of gravitational wave detectors, such as the LISA satellite, the Einstein Telescope, and the Lunar Gravitational Wave Antenna.Francesco Pannarale is an Associate Professor at “Sapienza” Univeristy of Rome, where he teaches Gravitational Waves, Compact Objects and Black Holes, Computing Methods for Physics,
Nuclear Transfer Protocols
by Paul J. VermaNuclear Transfer Protocols: Cell Reprogramming and Transgenesis is a comprehensive review of nuclear transfer technology in vertebrates, aimed at reprogramming differentiated nuclei and effecting targeted gene transfer. The authors provide readily reproducible techniques for the generation of cloned embryos and animals in a number of key research and commercially important vertebrates. Additional chapters provide alternative cutting-edge methods for nuclear transfer, such as zona-free nuclear transfer. Of immense benefit are descriptions of procedures associated with cloning, such as in vitro maturation of oocytes, activation and culture of cloned embryos, maintenance of pregnancy, and neonatal care of clones. Nuclear Transfer Protocols: Cell Reprogramming and Transgenesis provides an understanding of the factors involved in nuclear reprogramming, which is imperative for the success of cloning. A section dealing with such cloning-related issues as aging and normality of clones is also included, making this an essential comprehensive handbook for research and commercial laboratories involved in, or intending to work on, nuclear transfer. This book will prove beneficial to molecular biologists, stem cell biologists, clinicians, biotechnologists, students, veterinarians, and animal care technicians involved with reprogramming, nuclear transfer, and transgenesis.
Nuclear War: A Scenario
by Annie JacobsenThe INSTANT New York Times bestseller Instant Los Angeles Times bestsellerOne of NPR's Books We LoveOne of Newsweek Staffers' Favorite Books of the YearShortlisted for the Baillie Gifford Prize&“In Nuclear War: A Scenario, Annie Jacobsen gives us a vivid picture of what could happen if our nuclear guardians fail…Terrifying.&”—Wall Street Journal There is only one scenario other than an asteroid strike that could end the world as we know it in a matter of hours: nuclear war. And one of the triggers for that war would be a nuclear missile inbound toward the United States. Every generation, a journalist has looked deep into the heart of the nuclear military establishment: the technologies, the safeguards, the plans, and the risks. These investigations are vital to how we understand the world we really live in—where one nuclear missile will beget one in return, and where the choreography of the world&’s end requires massive decisions made on seconds&’ notice with information that is only as good as the intelligence we have. Pulitzer Prize finalist Annie Jacobsen&’s Nuclear War: A Scenario explores this ticking-clock scenario, based on dozens of exclusive new interviews with military and civilian experts who have built the weapons, have been privy to the response plans, and have been responsible for those decisions should they have needed to be made. Nuclear War: A Scenario examines the handful of minutes after a nuclear missile launch. It is essential reading, and unlike any other book in its depth and urgency.
Nuclear War and Environmental Catastrophe
by Noam Chomksy Laray Polk"There are two problems for our species' survival--nuclear war and environmental catastrophe, " says Noam Chomsky in this new book on the two existential threats of our time and their points of intersection since World War II.While a nuclear strike would require action, environmental catastrophe is partially defined by willful inaction in response to human-induced climate change. Denial of the facts is only half the equation. Other contributing factors include extreme techniques for the extraction of remaining carbon deposits, the elimination of agricultural land for bio-fuel, the construction of dams, and the destruction of forests that are crucial for carbon sequestration.On the subject of current nuclear tensions, Chomsky revisits the long-established option of a nuclear-weapon-free zone (NWFZ) in the Middle East, a proposal set in motion through a joint Egyptian Iranian General Assembly resolution in 1974.Intended as a warning, Nuclear War and Environmental Catastrophe is also a reminder that talking about the unspeakable can still be done with humor, with wit and indomitable spirit.
Nuclear Waste Management: Science, Technology, and Policy (Lecture Notes in Energy #83)
by Man-Sung YimThis book lays a comprehensive foundation for addressing the issue of safety in the lifecycle of nuclear waste. With the focus on the fundamental principles, the book covers key technical approaches to safety in the management of spent nuclear fuel, reprocessed high-level waste, low-level waste, and decommissioning wastes. Behaviors of nuclear waste in natural and engineered systems in relation to safety assessment are also described through the explanation of fundamental processes. For any country involved with the use of nuclear power, nuclear waste management is a topic of grave importance. Although many countries have heavily invested in nuclear waste management, having a successful national program still remains a major challenge. This book offers substantial guidance for those seeking solutions to these problems. As the problem of nuclear waste management is heavily influenced by social factors, the connection between technical and social issues in nuclear waste management is also discussed. The book is a core text for advanced students in nuclear and environmental engineering, and a valuable reference for those working in nuclear engineering and related areas.
Nuclear Waste Management, Nuclear Power, and Energy Choices
by Michael GreenbergHundreds of studies have investigated public perceptions and preferences about nuclear power, waste management, and technology. However there is clear lack of uniformity in the style, aims and methods applied. Consequently, the body of results is inconsistent and it is difficult to isolate relevant patterns or interpretations. Nuclear Waste Management, Nuclear Power and Energy Choices: Public Preferences, Perceptions and Trust presents a theoretical base for public reactions then classifies and reviews the large body of surveys carried out over the past decade. Particular focus is placed on residents within 50 miles US nuclear waste facilities due to the disproportionate presence of nuclear factors in their lives such as the legacy of nuclear waste disposal and job dependency. The motivations and reasons for their views such as fear, attraction to the economic benefits, trust of site managers and federal agencies, cultural views, personal history, and demographic attributes of the people are also considered to provide a balanced and detailed overview. Nuclear Waste Management, Nuclear Power and Energy Choices: Public Preferences, Perceptions and Trust includes a comprehensive treatment of the theories and literature, and most important is grounded in surveys in 2005, 2008, 2009, 2010, and 2011 which includes questions considering the impact of Fukushima on US public opinion. By including real life data alongside the analysis, Nuclear Waste Management, Nuclear Power, and Energy Choices: Public Preferences, Perceptions and Trust provides a relevant and concise reference for nuclear industry professionals. It also acts a resource for students and researchers studying nuclear-related topics including political, social and environmental factors. Particular focus is placed on residents within 50 miles US nuclear waste facilities due to the disproportionate presence of nuclear factors in their lives such as the legacy of nuclear waste disposal and job dependency. The motivations and reasons for their views such as fear, attraction to the economic benefits, trust of site managers and federal agencies, cultural views, personal history, and demographic attributes of the people are also considered to provide a balanced and detailed overview. Nuclear Waste Management, Nuclear Power and Energy Choices: Public Preferences, Perceptions and Trust includes a comprehensive treatment of the theories and literature, and most important is grounded in surveys in 2005, 2008, 2009, 2010, and 2011 which includes questions considering the impact of Fukushima on US public opinion. By including real life data alongside the analysis, Nuclear Waste Management, Nuclear Power, and Energy Choices: Public Preferences, Perceptions and Trust provides a relevant and concise reference for nuclear industry professionals. It also acts a resource for students and researchers studying nuclear-related topics including political, social and environmental factors. Particular focus is placed on residents within 50 miles US nuclear waste facilities due to the disproportionate presence of nuclear factors in their lives such as the legacy of nuclear waste disposal and job dependency. The motivations and reasons for their views such as fear, attraction to the economic benefits, trust of site managers and federal agencies, cultural views, personal history, and demographic attributes of the people are also considered to provide a balanced and detailed overview. Nuclear Waste Management, Nuclear Power and Energy Choices: Public Preferences, Perceptions and Trust includes a comprehensive treatment of the theories and literature, and most important is grounded in surveys in 2005, 2008, 2009, 2010, and 2011 which includes questions considering the impact of Fukushima on US public opinion. By including real life data alongside the analysis, Nuclear Waste Management, Nuclear Power, and Energy Choices: Public Preferences, Perceptions and Trust provides a relevant and concise reference for nuclear industry professionals. It also acts a resource for students and resear...
Nuclear Weapons (The MIT Press Essential Knowledge series)
by Mark WolvertonA primer on nuclear weapons, from the science of fission and fusion to the pursuit of mutual assured destruction, the SALT treaties, and the Bomb in pop culture.Although the world&’s attention has shifted to drone-controlled bombing and cyberwarfare, the threat of nuclear war still exists. There are now fourteen thousand nuclear weapons in the hands of the nine declared nuclear powers. Even though the world survived the Cold War, we need to understand what it means to live with nuclear weapons. In this volume in the MIT Press Essential Knowledge series, Mark Wolverton offers a primer on nuclear weapons, from the science of fission and fusion to the pursuit of mutual assured destruction, the SALT and START agreements, and the Bomb in pop culture. Wolverton explains the basic scientific facts, offers historical perspective, and provides a nuanced view of the unique political, social, and moral dilemmas posed by nuclear weapons. He describes the birth of the Bomb in 1945 and its use against the Japanese cities of Hiroshima and Nagasaki; explains how a nuclear bomb works; recounts episodes when the world came close to waging nuclear war, including the Cuban missile crisis in 1962; discusses nuclear policy and nuclear treaties; and traces the influence of such films as On the Beach, Dr. Strangelove, and The Day After.
Nuclear Weapons Proliferation in the Next Decade
by Peter R. LavoyThe intensification of the Iranian and North Korean nuclear crises has created new fears that deteriorating security conditions in the Middle East, Northeast Asia, and other regions will lead additional countries to seek their own nuclear arsenals in the years to come. This special issue examines the factors that are likely to shape nuclear weapons proliferation over the next decade. The internationally recognized authors of this issue, many of whom are prominent scholars and others of whom have held influential governmental positions with responsibility for countering nuclear proliferation, bring to light the conditions and events that might drive new countries to pursue nuclear weapons; the indicators and cautionary signs that can provide early warning that a country is interested in building nuclear bombs; and the policy and military measures that can be adopted to prevent or at least dissuade new proliferators. The introductory chapter develops a novel analytical approach focusing on the role of nuclear myths and mythmakers and the subsequent chapters draw on this approach to help analysts better understand and policy makers better manage nuclear proliferation over the next ten years.
Nuclear Zero?: Lessons from the Last Time We Were There
by George H. Quester"George H. Quester argues that the possibility of nuclear war continues to loom despite the reduction in stockpiles by the major powers. Supporters of total nuclear disarmament often dismiss pessimistic objections to the possibility of reaching nuclear zero as being hypothetical, but this book looks at real illustrations for this possibility, taken from the years that gave the world the Manhattan Project.Any advocate of total nuclear disarmament must deal with the challenge of ""realist"" analysts of international relations, those who worry that being at zero nuclear weapons, or even close to zero, would be unstable and dangerous. Mutual fears could be self-confirming, leading to cheating on disarmament, and even nuclear war. While such fears are often dismissed as theoretical or hypothetical, this book attempts to test them against the real-life experience of the last time we were at nuclear zero. The years from 1933 to 1945 saw many such self-confirming fears, leading to the Manhattan Project and the nuclear destruction of Hiroshima and Nagasaki.Optimism about the future cannot be ruled out totally, but the history of our experience with nuclear disarmament must be examined carefully to identify the crucial prerequisites for elimination of such weapons of mass destruction. This book is required reading for courses on arms control, defense policy, and international relations, or for readers looking for historical background on a critical global issue."
Nucleares, ¿por qué no?: Cómo afrontar el futuro de la energía
by Manuel Lozano LeyvaUna visión global del problema energético y de la necesidad de reabrir el debate sobre la energía nuclear. El futuro de la energía es uno de los mayores retos del siglo XXI. Los combustibles fósiles se acaban y son muy contaminantes, las energías renovables aún están en desarrollo y la controvertida energía nuclear vive en el alambre: está sujeta a una moratoria en países como España o Alemania, se ha prohibido en algunos y es clave en otros como Francia y Suecia. Lozano Leyva se enfrenta, con este libro, a los prejuicios que a menudo impiden un debate sereno e informado, y nos habla de la energía nuclear sin eludir sus aspectos más espinosos: su historia, su papel en la naturaleza, su uso militar y pacífico, los problemas de residuos, seguridad, contaminación y proliferación. Es un libro que no está a favor ni en contra de la energía nuclear, sino que defiende la necesidad de información veraz a fin de que cada uno pueda tener su propia opinión en una cuestión clave para nuestras sociedades. «Uno de nuestros mejores cerebros.»ABC
Nuclease Methods and Protocols
by Catherine H. ScheinScientists at the forefront of academic research and pharmaceutical drug development offer their well-polished methodologies for protein nucleases that can be used to determine their activity, structure, interaction with other molecules, and physiological role. Protocols range from methods for characterizing nucleases, to correlating nuclease structure and function, to the use of nucleases in cloning. Recombinant techniques for expressing and isolating nucleases are covered, as well as methods specific for dealing with protein/nucleic acid complexes. Each chapter contains a minireview of a specific nuclease or nuclease-related theme, a discussion of why and when to use the assay in question, and an explanation of the thinking that went into its development. Comprehensive and highly practical, Nuclease Methods and Protocols offers both novice and experienced researchers a deeper understanding of their importance in cell metabolism, growth control mechanisms, and, increasingly, in diagnostics and therapeutics.
Nucleation and Crystal Growth: Metastability of Solutions and Melts
by Keshra SangwalA unique text presenting practical information on the topic of nucleation and crystal growth processes from metastable solutions and melts Nucleation and Crystal Growth is a groundbreaking text thatoffers an overview and description of the processes and phenomena associated with metastability of solutions and melts. The author—a noted expert in the field—puts the emphasis on low-temperature solutions that are typically involved in crystallization in a wide range of industries. The text begins with a review of the basic knowledge of solutions and the fundamentals of crystallization processes. The author then explores topics related to the metastable state of solutions and melts from the standpoint of three-dimensional nucleation and crystal growth. Nucleation and Crystal Growth is the first text that contains a unified description and discussion of the many processes and phenomena occurring in the metastable zone of solutions and melts from the consideration of basic concepts of structure of crystallization. This important text: Outlines an interdisciplinary approach to the topic and offers an essential guide for crystal growth practitioners in materials science, physics, and chemical engineering Contains a comprehensive content that details the crystallization processes starting from the initial solutions and melts, all the way through nucleation, to the final crystal products Presents a unique focus and is the first book on understanding, and exploiting, metastability of solutions and melts in crystallization processes Written for specialists and researchers in the fields of materials science, condensed matter physics, and chemical engineering. Nucleation and Crystal Growth is a practical resource filled with hands-on knowledge of nucleation and crystal growth processes from metastable solutions and melts.
Nucleation of Gas Hydrates
by Nobuo MaedaThis book introduces readers to experimental techniques of general utility that can be used to practically and reliably determine nucleation rates. It also covers the basics of gas hydrates, phase equilibria, nucleation theory, crystal growth, and interfacial gaseous states. Given its scope, the book will be of interest to graduate students and researchers in the field of hydrate nucleation.The formation of gas hydrates is a first-order phase transition that begins with nucleation. Understanding nucleation is of interest to many working in the chemical and petroleum industry, since nucleation, while beneficial in many chemical processes, is also a concern in terms of flow assurance for oil and natural gas pipelines. A primary difficulty in the investigation of gas hydrate nucleation has been researchers’ inability to determine and compare the nucleation rates of gas hydrates across systems with different scales and levels of complexity, which in turn has limited their ability to study the nucleation process itself.This book introduces readers to experimental techniques that can be used to practically and reliably determine the nucleation rates of gas hydrate systems. It also covers the basics of gas hydrates, phase equilibria, nucleation theory, crystal growth, and interfacial gaseous states. Given its scope, the book will be of interest to graduate students and researchers in the field of hydrate nucleation.
Nucleation of Particles from the Gas Phase
by Steven L. GirshickFormation of small solid and liquid particles is vital for a variety of natural and technological phenomena, from the evolution of the universe, through atmospheric air pollution and global climate change. Despite its importance, nucleation is still not well understood, and this unique book addresses that need. It develops the theory of nucleation from first principles in a comprehensive and clear way, and uniquely brings together classical theory with contemporary atomistic approaches. Important real-world situations are considered, and insight is given into cases typically not considered such as particle formation in flames and plasmas. Written by an author with more than 35 years of experience in the field, this will be an invaluable reference for senior undergraduates and graduate students in a number of disciplines, as well as for researchers in fields ranging from climate science and astrophysics to design of systems for semiconductor processing and materials synthesis.
Nucleation Theory
by V. I. KalikmanovOne of the most striking phenomena in condensed matter physics is the occurrence of abrupt transitions in the structure of a substance at certain temperatures or pressures. These are first order phase transitions, and examples such as the freezing of water are familiar in everyday life. The conditions at which the transformation takes place can sometimes vary. For example, the freezing point of water is not always 0°C, but the liquid can be supercooled considerably if it is pure enough and treated carefully. The reason for this phenomenon is nucleation. This monograph covers all major available routes of theoretical research of nucleation phenomena (phenomenological models, semi-phenomenological theories, density functional theories, microscopic and semi-microscopic approaches), with emphasis on the formation of liquid droplets from a metastable vapor. Also, it illustrates the application of these various approaches to experimentally relevant problems. In spite of the familiarity of the involved phenomena, it is still impossible to calculate nucleation accurately, as the properties and the kinetics of the daughter phase are insufficiently well known. Existing theories based upon classical nucleation theory have on the whole explained the trends in behavior correctly. However they often fail spectacularly to account for new data, in particular in the case of binary or, more generally, multi-component nucleation. The current challenge of this book is to go beyond such classical models and provide a more satisfactory theory by using density functional theory and microscopic computer simulations in order to describe the properties of small clusters. Also, semi-phenomenological models are proposed, which attempt to relate the properties of small clusters to known properties of the bulk phases. This monograph is an introduction as well as a compendium to researchers in soft condensed matter physics and chemical physics, graduate and post-graduate students in physics and chemistry starting on research in the area of nucleation, and to experimentalists wishing to gain a better understanding of the efforts being made to account for their data.
Nuclei in the Cosmos: Proceedings of the Second International Symposium on Nuclear Astrophysics, held in Karlsruhe, Germany, 6-10 July 1992
by F Käppeler K Wisshak Kernforschungszentrum KarlsruheNuclei in the Cosmos, a volume of conference papers, gathers together astronomers, astrophysicists, and nuclear physicists for a thorough discussion of nucleosynthesis, its role in the evolution of the universe, and its intriguing possibilities as a diagnostic tool for stellar interiors. Nineteen invited papers provide a solid review of nucleosynthesis topics, and approximately another 70 papers bring you up-to-date on the forefront of research in this quickly-developing area.
Nuclei in the Cosmos XV (Springer Proceedings in Physics #219)
by Alba Formicola Matthias Junker Lucio Gialanella Gianluca ImbrianiThese peer-reviewed NIC XV conference proceedings present the latest major advances in nuclear physics, astrophysics, astronomy, cosmochemistry and neutrino physics, which provide the necessary framework for a microscopic understanding of astrophysical processes. The book also discusses future directions and perspectives in the various fields of nuclear astrophysics research. In addition, it also includes a limited number of section of more general interest on double beta decay and dark matter.
Nucleic Acid Amplification Strategies for Biosensing, Bioimaging and Biomedicine
by Shusheng Zhang Sai Bi Xinyue SongThis book describes the rational design, development and application of nucleic acid amplification strategies for biosensing, bioimaging and biomedicine. It consists of fifteen chapters demonstrating the use of these strategies in various areas, including fluorescence techniques, Chemiluminescence biosensors, electrochemiluminescence biosensors, colorimetric assays, surface plasmon resonance technologies, electrochemical DNA sensors, photoelectrochemical biosensor, nanopore sensors, quartz crystal microbalance, fluorescence imaging, surface-enhanced Raman spectroscopy, in vitro and in vivo metal ions detection, theranostics and microdroplet chips. Offering a collection of reviews illustrating the latest advances in biochemical analysis and therapeutics, the book shares valuable insights into current challenges and future prospects, making it a valuable resource for a wide readership in the various fields of biosensing, bioimaging and biomedicine.
Nucleic Acid and Peptide Aptamers
by Günter MayerAfter the deciphering of the human genome and the genomes of many other organisms, the investigation of the function of gene products and their orchestral interplay is now one of the most important challenges in the life sciences. In "Nucleic Acid and Peptide Aptamers: Methods and Protocols", expert researchers contribute state-of-the-art methods focused on these two vital molecule types which are so often employed for in vitro selection procedures. Divided conveniently into two distinct parts beginning with nucleic acid aptamers and ending with peptide aptamers, the volume provides methodologies for the isolation, characterization, and application of both types. Written in the highly successful Methods in Molecular BiologyTM series format, all chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and Notes sections, which highlight tips on troubleshooting and avoiding known pitfalls. Cutting-edge and easy to use, "Nucleic Acid and Peptide Aptamers: Methods and Protocols" will provide researchers with an inspiring and helpful guide to the application of these compounds to their own distinct research issues.
Nucleic Acid Aptamers: Selection, Characterization, and Application (Methods in Molecular Biology #2570)
by Günter Mayer Marcus M. MengerThis updated book reflects improvements in a variety of techniques used to study the aptamer field. Beginning with a section on selection procedures, the volume continues with methods to characterize aptamers’ interaction and structural properties by biophysical approaches, as well as a variety of applications that have been adapted to the aptamer compound class. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Nucleic Acid Aptamers: Selection, Characterization, and Application, Second Edition serves as an ideal guide for researchers aiming to further our understanding of aptamer biology and more.
Nucleic Acid-Based Nanomaterials: Stabilities and Applications
by Yunfeng Lin Shaojingya GaoNucleic Acid-Based Nanomaterials Learn about the cutting-edge nanotechnologies that play an important role in clinical and medical therapies Nucleic acids, the biomolecules that carry most of nature’s critical genetic information, are an omnipresent component of life on earth. Nanomaterials incorporating or otherwise built around nucleic acids and their key properties have a number of clinical and medical applications, including drug delivery and more. Biomaterials scientists and other professionals in these fields can benefit enormously from increased knowledge of these invaluable materials. Nucleic Acid-Based Nanomaterials supplies a thorough, rigorous overview of these materials and their possible applications. Beginning with an introduction to the history of nanomaterials and their nucleic acid-based subcategories, the book offers a detailed and state-of-the-art survey of the current research into these molecules, efforts to increase their biostability, and their incorporation into a range of industries. The result is an essential contribution to materials science in a variety of life-saving contexts. Nucleic Acid-Based Nanomaterials readers will also find: Application-oriented structure that grounds general concepts in their specific instantiationsDetailed discussion of applications including drug delivery, tissue engineering, antimicrobial therapy, and moreA rigorous yet accessible approach suitable for both academia and industry Nucleic Acid-Based Nanomaterials is ideal for chemists of all types, particularly biochemists and medical chemists, and those in industry.
Nucleic Acid Biology and its Application in Human Diseases
by Subhrangsu Chatterjee Samit ChattopadhyayThis book reviews the structure-function relationship of nucleic acids, their role in the pathophysiology of the diseases, and as therapeutic targets for human diseases. The chapters discuss the role of nucleic acids in inflammatory diseases, neurodegenerative diseases, and cancer. The book also describes recent advancements in nucleic acid-based therapy, the application of nucleic acids in diagnostics, in the development of nano-carriers, logic gates, and sensors. It explores the use of nucleic acids (RNA and DNA) as a unique and multifunctional platform for numerous applications, including therapeutics, diagnostics, nanodevices, and materials. It further examines the role of DNA methylation, histone modifiers and readers, chromatin remodelers, microRNAs, and other components of chromatin in the progression of cancer. The book also discusses the applications of nucleic acid as a vaccine and as a gene-editing tool. It also provides an overview of the clinical trials using genome editing platforms for disease treatment and the challenges in implementing the editing technology. Finally, the book elucidates a representative description of challenges associated with nucleic acid-mediated therapy.
Nucleic Acid Blotting
by D C Darling P M BricknellDiscusses very widely-used techniques. Aimed specifically at the newcomer. Provides detailed explanations unavailable elsewhere. Points out pitfalls and provides solutions. Invaluable help for experienced laboratories training newcomers.