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pH-Messung: Der Leitfaden für Praktiker
by Ralf DegnerEin Buch fur Praktiker, das auch dem erfahrenen Profi noch einiges Neues bietet. Themen wie die Kalibrierung und die Qualitatssicherung werden Sie aus einem vollig neuen Blickwinkel betrachten. Anwendung: Sie erhalten eine Vielzahl an Beispielen fur die praktische pH-Messung in den verschiedensten Materialen, sei es die Online-Messung im Abwasser, die Kontrollmessung von Textilien oder die Profil-Messung in Seen. Empfehlungen zu allen Komponenten der Messeinrichtung machen das Buch auch fur die Beschaffung zu einer wertvollen Unterlage. Grundlagen: Sie erhalten eine Einfuhrung daruber, was der pH-Wert ist, wie die Messkette funktioniert und wie sich Storungen auswirken. Sie erfahren alles, was notig ist, um das Verhalten einer pH-Messkette richtig beurteilen zu konnen. Qualitatssicherung: Das Umsetzen der Prufmitteluberwachung beeinflusst die bisher gewohnten Verfahrensablaufe erheblich. Lesen Sie wie die Qualitatssicherung speziell fur die pH-Messung ablauft und welche Unsicherheit Ihre Messergebnisse haben konnen. Dieses Buch ist ein 'Muss' fur alle, die * in irgend einer Weise mit pH-Messung zu tun haben * Normen, Gebrauchs- und Prufanweisungen fur die pH-Messung erstellen * pH-Messeinrichtungen herstellen.
Phaenomena (Johns Hopkins New Translations from Antiquity)
by AratusAfter the Iliad and the Odyssey, the Phaenomena was the most widely read poem in the ancient world. Its fame was immediate. It was translated into Latin by Ovid and Cicero and quoted by St. Paul in the New Testament, and it was one of the few Greek poems translated into Arabic. Aratus’ Phaenomena is a didactic poem—a practical manual in verse that teaches the reader to identify constellations and predict weather. The poem also explains the relationship between celestial phenomena and such human affairs as agriculture and navigation. Despite the historical and pedagogical importance of the poem, no English edition suitable for students and general readers has been available for decades. Aaron Poochigian’s lively translation makes accessible one of the most influential poets of antiquity. Poochigian's interpretation of the Phaenomena reestablishes the ancient link between poetry and science and demonstrates that verse is an effective medium for instruction. Featuring references to Classical mythology and science, star charts of the northern and southern skies, extensive notes, and an introduction to the work’s stylistic features and literary reception, this dynamic work will appeal to students of Ancient Greece who want to deepen their understanding of the Classical world.
Phage Display: Methods and Protocols (Methods in Molecular Biology #2702)
by Michael Hust Theam Soon LimThis second edition details new and updated methods on different antibody libraries, along with novel approaches for antibody discovery. Chapters focuses on the construction of antibody libraries, antibody expression, complementary approaches for antibody selection, and other phage display related applications. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Phage Display: Methods and Protocols, Second Edition aims to be a useful and practical guide to new researchers and experts looking to expand their knowledge.
Phage Display In Biotechnology and Drug Discovery (Drug Discovery Series)
by Sachdev S. Sidhu Clarence Ronald GeyerPhage Display in Biotechnology and Drug Discovery, Second Edition provides a comprehensive view of the impact and promise of phage display in drug discovery and biotechnology. Building on the success of its previous edition, the book discusses current theories, principles, and methods in the field and demonstrates applications for peptide phage dis
Phage Engineering and Analysis: Methods and Protocols (Methods in Molecular Biology #2793)
by Huan Peng Jianfeng Liu Irene A. ChenThis volume explores the latest developments in the study and application of phage biology. The chapters in this book are divided into five parts and cover topics such as phage display, selection, and evolution; genetic and chemical modification of phages; analyzing structures by electron microscopy; characterizing phage transcripts and proteins; and the biology of whole phages. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and comprehensive, Phage Engineering and Analysis: Methods and Protocols is a valuable resource that will help both expert and novice researchers - from backgrounds ranging from microbiologists to biophysicists to chemical engineers - further enhance their understandingof this important and evolving field.
Phage Therapy: A Practical Approach
by Andrzej Górski Ryszard Międzybrodzki Jan BorysowskiThis book gives a detailed yet clear insight into the current state of the art of the therapeutic application of bacteriophages in different conditions. The authors bring in their practical expertise within their respective fields of expertise and provide an excellent overview of the potential and actual use of phage therapy. Topics like economic feasibility compared to traditional antibiotics and also regulatory issues are discussed in far detail. This new volume is therefore a valuable resource for individuals engaged in the medical application of novel phage therapies.
Phagocytosis and Phagosomes: Methods and Protocols (Methods in Molecular Biology #2692)
by Roberto J. BotelhoThis volume explores updated and entirely new experimental approaches used to investigate phagocytosis and phagosome maturation. In order to aid in the study of engulfment, maturation, resolution, and pathogen manipulation of phagocytes, the book features methodology to quantify uptake and maturation specific to certain phagocytes, particles, or pathogens, while other chapters offer methods that can be applied generically across the field. Methods are presented to study phagocytosis and phagosome maturation in vivo, in cellulo, and through in vitro analyses. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Phagocytosis and Phagosomes: Methods and Protocols, Second Edition serves as a vital resource for both experts in the field as well as for investigators delving into phagocytosis and phagosome maturation for the first time.
The Phanerozoic Geology and Natural Resources of Egypt (Advances in Science, Technology & Innovation)
by Zakaria Hamimi Hassan Khozyem Thierry Adatte Fadi H. Nader Francisca Oboh-Ikuenobe Mohamed K. Zobaa Haytham El AtfyThe Phanerozoic Geology and Natural Resources of Egypt includes a series of chapters written by highly qualified group of researchers whose expertise is recognized and appreciated not only in Egypt, but also in the world over. The chapters span a wide range of geological subdisciplines including tectonics, paleogeography, stratigraphy, sedimentology, paleontology, groundwater, and energy resources, just to name a few. In this regard, the book provides the reader with ample knowledge about the different facets of the fascinating and always intriguing geology of Egypt since the Precambrian time. For a junior researcher or a geoscience student, the book is a comprehensive, multidisciplinary one-stop resource that they will continue to reference and rely on for years to come. For a more experienced scientist, the book summarizes the current state of knowledge, highlights the magnitude of complexity of the geology of Egypt and northeast Africa, and reveals potential areas where future research should be directed. The book is written in simple, easy to understand English language and contains very useful high-quality illustrations. Last but not least, The Phanerozoic Geology and Natural Resources of Egypt has been reviewed and edited by world class, highly ranked geoscientists from Egypt, Europe, and USA.
Phantasmatic Shakespeare: Imagination in the Age of Early Modern Science
by Suparna RoychoudhuryRepresentations of the mind have a central place in Shakespeare’s artistic imagination, as we see in Bottom struggling to articulate his dream, Macbeth reaching for a dagger that is not there, and Prospero humbling his enemies with spectacular illusions. Phantasmatic Shakespeare examines the intersection between early modern literature and early modern understandings of the mind’s ability to perceive and imagine. Suparna Roychoudhury argues that Shakespeare’s portrayal of the imagination participates in sixteenth-century psychological discourse and reflects also how fields of anatomy, medicine, mathematics, and natural history jolted and reshaped conceptions of mentality. Although the new sciences did not displace the older psychology of phantasms, they inflected how Renaissance natural philosophers and physicians thought and wrote about the brain’s image-making faculty. The many hallucinations, illusions, and dreams scattered throughout Shakespeare’s works exploit this epistemological ferment, deriving their complexity from the ambiguities raised by early modern science.Phantasmatic Shakespeare considers aspects of imagination that were destabilized during Shakespeare’s period—its place in the brain; its legitimacy as a form of knowledge; its pathologies; its relation to matter, light, and nature—reading these in concert with canonical works such as King Lear, Macbeth, and The Tempest. Shakespeare, Roychoudhury shows, was influenced by paradigmatic epistemic shifts of his time, and he in turn demonstrated how the mysteries of cognition could be the subject of powerful art.
Phantom Wheel: A Hackers Novel
by Tracy DeebsThe digital apocalypse has arrived and the future is here in this addictive technological thriller full of twists and turns. Perfect for fans of Nerve! Being recruited by the CIA to join a top-secret intelligence program should be the opportunity of a lifetime. For Issa, it's a shot at creating a new and better life for herself and her siblings. For clever con artist Harper, it's a chance to bury the secrets of her troubled past and make sure that those secrets stay buried. But for Owen--honor student, star quarterback, and computer-hacking genius--it sounds like a trap. He's right. Owen discovers that instead of auditioning for the CIA, they've all been tricked by a multibillion-dollar tech company into creating the ultimate computer virus. It's called Phantom Wheel, and it's capable of hacking anyone on Earth, anywhere, at any time. And thanks to six teenagers, it's virtually unstoppable. Horrified by what they've done, the hackers must team up to stop the virus before the world descends into chaos. But working together is easier said than done, especially as the lines start to blur between teammate, friend, and more than friend. Because how do you learn to trust someone when you've spent your entire life exploiting that same trust in others?
Phantoms in the Brain: Probing the Mysteries of the Human Mind
by V. S. Ramachandran Sandra BlakesleeIn Phantoms in the Brain, Dr. Ramachandran recounts how his work with patients who have bizarre neurological disorders has shed new light on the deep architecture of the brain, and what these findings tell us about who we are, how we construct our body image, why we laugh or become depressed, why we may believe in God, how we make decisions, deceive ourselves and dream, perhaps even why we're so clever at philosophy, music and art.
The Phantoms of Medical and Health Physics
by Larry A. Dewerd Michael KissickThe purpose and subject of this book is to provide a comprehensive overview of all types of phantoms used in medical imaging, therapy, nuclear medicine and health physics. For ionizing radiation, dosimetry with respect to issues of material composition, shape, and motion/position effects are all highlighted. For medical imaging, each type of technology will need specific materials and designs, and the physics and indications will be explored for each type. Health physics phantoms are concerned with some of the same issues such as material heterogeneity, but also unique issues such as organ-specific radiation dose from sources distributed in other organs. Readers will be able to use this book to select the appropriate phantom from a vendor at a clinic, to learn from as a student, to choose materials for custom phantom design, to design dynamic features, and as a reference for a variety of applications. Some of the information enclosed is found in other sources, divided especially along the three categories of imaging, therapy, and health physics. To our knowledge, even though professionally, many medical physicists need to bridge the three catagories described above.
Phantoms of the Prairie
by John W. LaundréLast seen in the 1880s, cougars (also known as pumas or mountain lions) are making a return to the plains regions of the Midwest. Their comeback, heralded by wildlife enthusiasts, has brought concern and questions to many. Will the people of the region make room for cougars? Can they survive the highly altered landscape of the Midwest? Is there a future for these intrepid pioneers if they head even farther east? Â Â Â Using GIS technology, and historical data, among many other methods, Phantoms of the Prairie takes readers on a virtual journey, showing how the cougar might move over the landscape with minimal human contact. Drawing on his years of research on cougars, John W. Laundré offers an overview of what has been, what is, and what might be regarding the return of cougars to their ancestral prairie homeland.
Pharma and Profits: Balancing Innovation, Medicine, and Drug Prices
by John L. LaMattinaHigh-level commentary on various facets of the pharmaceutical industry from a key leader in the field This book clearly explains the value that the pharmaceutical industry offers to society which is often underreported against the more negative topic of high drug prices. It also offers an overview for drug discovery and development professionals, highlighting the challenges that such drug hunters should be aware of when developing new drugs. Case studies to illustrate topics like hepatitis C, mRNA vaccines, insulin, and price controls are included to aid in seamless reader comprehension. Written by John LaMattina, former president of Pfizer Global Research and Development and well-known speaker and writer for the pharma industry, sample topics covered and questions explored within the work include: Fiscal consequences of curing hepatitis C mRNA vaccines and the race for a cure Why the government does not deserve a piece of Biopharma’s profits Paying for drugs whose ultimate value is unknown The impact of reduced revenues on R&DThis book is a must-read for biopharmaceutical professionals and executives who wish to gain high-level insight into key challenges that must be first understood, then overcome, within the pharmaceutical industry.
Pharma-Ecology: The Occurrence and Fate of Pharmaceuticals and Personal Care Products in the Environment
by Patrick K. JjembaThe revised edition of the guide to environmental impact of pharmaceuticals and personal care products The revised and updated second edition of Pharma-Ecology joins the health and environmental sciences professions' concern over the occurrence and fate of pharmaceutical and personal care products (PPCPs) in the environment and explores how to best minimize their impact. The text highlights the biological effects of various classes of pharmaceutical compounds under clinical settings, their modes of action, and approximate quantities consumed. The second edition contains the most recent knowledge about the ecological impact of PPCPs as more sensitive detection techniques have become available, since the book was first published. The second edition offers the most up-to-date information on pharma ecology and bridges the gap between medicine, public health, and environmental science. This new edition contains helpful learning objectives for each chapter, as well as a brief section at the end of each chapter that presents a set of open ended questions. This vital resource: • Explores the biological effects of pharmaceutical compounds under clinical settings, their modes of action, approximate quantities consumed • Provides researchers and scientists with critical background data on the environmental impacts of PPCPs • Contains the most current information on PPCPs' ecological impacts, based on new detection techniques • Bridges the gap between medicine, public health, and environmental science Written for ecologists, engineers, microbiologists, pharmacists, toxicologists, chemists, physicians, and veterinarians involved in pollution and environmental analysis, the second edition of Pharma-Ecology contains the most current information available on the environmental impact of pharmaceuticals and personal care products.
Pharmaceutical Accumulation in the Environment: Prevention, Control, Health Effects, and Economic Impact
by Walter E. GoldsteinA Proactive Approach to Improving and Protecting the EnvironmentThe accumulation of pharmaceuticals in the environment is a growing concern, the magnitude of which has not been determined, yet cannot be ignored. Touting the benefits of research and discovery as it relates to a pharmaceutical presence in the environment, Pharmaceutical Accumulation
Pharmaceutical Amorphous Solid Dispersions
by Ann NewmanProviding a roadmap from early to late stages of drug development, this book overviews amorphous solid dispersion technology - a leading platform to deliver poorly water soluble drugs, a major hurdle in today's pharmaceutical industry. * Helps readers understand amorphous solid dispersions and apply techniques to particular pharmaceutical systems * Covers physical and chemical properties, screening, scale-up, formulation, drug product manufacture, intellectual property, and regulatory considerations * Has an appendix with structure and property information for polymers commonly used in drug development and with marketed drugs developed using the amorphous sold dispersion approach * Addresses global regulatory issues including USA regulations, ICH guidelines, and patent concerns around the world
Pharmaceutical Analysis for Small Molecules
by Behnam DavaniA comprehensive introduction for scientists engaged in new drug development, analysis, and approvals Each year the pharmaceutical industry worldwide recruits thousands of recent science graduates—especially chemistry, analytical chemistry, pharmacy, and pharmaceutical majors—into its ranks. However, because of their limited background in pharmaceutical analysis most of those new recruits find making the transition from academia to industry very difficult. Designed to assist both recent graduates, as well as experienced chemists or scientists with limited regulatory, compendial or pharmaceutical analysis background, make that transition, Pharmaceutical Analysis for Small Molecules is a concise, yet comprehensive introduction to the drug development process and analysis of chemically synthesized, small molecule drugs. It features contributions by distinguished experts in the field, including editor and author, Dr. Behnam Davani, an analytical chemist with decades of technical management and teaching experience in compendial, regulatory, and industry. This book provides an introduction to pharmaceutical analysis for small molecules (non-biologics) using commonly used techniques for drug characterization and performance tests. The driving force for industry to perform pharmaceutical analyses is submission of such data and supporting documents to regulatory bodies for drug approval in order to market their products. In addition, related required supporting studies including good laboratory/documentation practices including analytical instrument qualification are highlighted in this book. Topics covered include: Drug Approval Process and Regulatory Requirements (private standards) Pharmacopeias and Compendial Approval Process (public standards) Common methods in pharmaceutical analysis (typically compendial) Common Calculations for assays and impurities and other specific tests Analytical Method Validation, Verification, Transfer Specifications including how to handle out of specification (OOS) and out of trend (OOT) Impurities including organic, inorganic, residual solvents and elemental impurities Good Documentation Practices for regulatory environment Management of Analytical Laboratories Analytical Instrument Qualifications including IQ, OQ, PQ and VQ Due to global nature of pharmaceutical industry, other topics on both regulatory (ICH) and Compendial harmonization are also highlighted. Pharmaceutical Analysis for Small Molecules is a valuable working resource for scientists directly or indirectly involved with the drug development process, including analytical chemists, pharmaceutical scientists, pharmacists, and quality control/quality assurance professionals. It also is an excellent text/reference for graduate students in analytical chemistry, pharmacy, pharmaceutical and regulatory sciences.
Pharmaceutical and Medical Applications of Near-Infrared Spectroscopy
by Emil W. Ciurczak Benoit IgneSince the completion of the first edition of this book, major developments have occurred in the pharmaceutical industry that have shaped the field of near-infrared (NIR) spectroscopy. A new initiative from the U.S. Food and Drug Administration (FDA) to modernize regulations of pharmaceutical manufacturing and drug quality has helped position NIR sp
Pharmaceutical and Medical Device Validation by Experimental Design
by Lynn D. TorbeckThis title demonstrates how designed experiments are the most scientific, efficient, and cost effective method of data collection for validation in a laboratory setting. Intended as a learn-by-example guide, Pharmaceutical and Medical Device Validation by Experimental Design demonstrates why designed experiments are the most logical and rational ap
Pharmaceutical and Nutraceutical Potential of Cyanobacteria
by Muhammad Aamer Mehmood Pradeep Verma Maulin P. Shah Michael J. BetenbaughCyanobacteria are the extraordinary microbes that are believed to have started life on Earth. It's been billions of years since they colonized this planet. Now, the question arises, what has made them so successful? The answer to this question lies in their remarkable potential to survive unfavorable environments, their substantial ability to fix the atmospheric carbon through photosynthesis, and their amazing secondary metabolites having antioxidant, osmo-protectants, and stress-tolerance abilities. Research on cyanobacteria has shown that these secondary metabolites and the substantial photosynthetic rates of cyanobacteria can be exploited for environmental, industrial, nutraceutical, and pharmaceutical applications. This book “Pharmaceutical and Nutraceutical Potential of Cyanobacteria” is a collection of 14 book chapters that have covered almost all aspects related to the opportunities, challenges, and potential applications whileemploying cyanobacteria as feedstock for various industrial and environmental applications with a special focus on pharmaceutical and nutraceutical applications. Some sections have also covered the enhanced biosynthesis, extraction, storage, and marketing of the cyanobacterial bioactive compounds (phycobilins, carotenoids, fatty acids, amino acids), and applications of cyanobacteria as food/feed of the future. We believe that this book will provide substantial learning opportunities to the readers including graduate students, academicians, phycologists, policymakers, environmental entrepreneurs, and industrialists. This book could be included in SDG 12 publications.
Pharmaceutical Applications of Membrane Sensors
by Vasile V. CosofretA one-of-a-kind book discussing drug-membrane sensors in pharmaceutical analysisPharmaceutical Applications of Membrane Sensors is the first book to deal with the theory of drug-membrane sensors, as well as applications of such devices in pharmaceutical analysis. The book contains three main parts. The three major sections of the book cover the design and principles of membrane drug sensors, the use of membrane sensors in the analysis of pharmaceuticals, and various aspects of drug release monitoring by membrane sensors. Detailed analytical methods for more than 400 organic pharmaceuticals assayed by membrane sensor techniques are presented.Pharmaceutical Applications of Membrane Sensors will be a valuable reference for specialists in analytical and pharmaceutical chemistry, electroanalytical chemistry, medicine, pharmaceutical sciences, and pharmacology.
Pharmaceutical Applications of Supramolecules
by Nidhi Goel Naresh KumarThis book outlines the use of supramolecules as different pharmaceutical drugs. Supramolecular chemistry in pharmaceutical sciences is quite a young and rapidly developing field. Supramolecular assemblies might offer an alternative for existing pharmaceutical formulations, as they facilitate the improvement of physicochemical and pharmacological properties i.e., higher bioavailability, better biocompatibility and drug-targeting, fewer multidrug-resistances. This book offers an overview of the recent advances in supramolecular structures and discusses the future aspects and challenges related to the development of these molecules, providing also a perspective on how to overcome these issues. Divided into 13 chapters contributed by experts in their field, the book provides a deeper understanding of intermolecular forces playing pivotal roles in mediating the interactions between chemical molecules and biological systems by focusing on different applications of supramolecular compounds. In this book, readers will find valuable insights into the preparation of supramolecules and the latest research and development trends of supramolecules as anticancer drugs, including liquid-crystalline supramolecular assemblies, and as antimicrobial, antiviral, anti-inflammatory and cardiovascular drugs. Particular attention is given to the application of supramolecules in the fields of biomedicine, bioimaging, and vaccine development. Given its breadth, this book will appeal to a wide readership from researchers and students interested in these fields to professionals in the pharma industry.
Pharmaceutical Aspects of Oligonucleotides
by Patrick CouvreurOligonucleotides diffuse poorly through biological barriers, including cell membranes. They are also rapidly degraded in vivo by nucleuses. Aiming to improve the administration of compounds, the book studies the development of nucleotide chemistry.
Pharmaceutical Biotechnology: A Focus on Industrial Application
by Adalberto Pessoa Jr., Michele Vitolo Paul Frederick LongPharmaceutical Biotechnology: A Focus on Industrial Application covers the development of new biopharmaceuticals as well as the improvement of those being produced. The main purpose is to provide background and concepts related to pharmaceutical biotechnology, together with an industrial perspective. This is a comprehensive text for undergraduates, graduates and academics in biochemistry, pharmacology and biopharmaceutics, as well as professionals working on the interdisciplinary field of pharmaceutical biotechnology. Written with educators in mind, this book provides teachers with background material to enhance their classes and offers students and other readers an easy-to-read text that examines the step-by-step stages of the development of new biopharmaceuticals. Features: Discusses specific points of great current relevance in relation to new processes as well as traditional processes Addresses the main unitary operations used in the biopharmaceutical industry such as upstream and downstream Includes chapters that allow a broad evaluation of the production process Dr. Adalberto Pessoa Jr. is Full Professor at the School of Pharmaceutical Sciences of the University of São Paulo and Visiting Senior Professor at King’s College London. He has experience in enzyme and fermentation technology and in the purification processes of biotechnological products such as liquid–liquid extraction, cross-flow filtration and chromatography of interest to the pharmaceutical and food industries. Dr. Michele Vitolo is Full Professor at the School of Pharmaceutical Sciences of the University of São Paulo. He has experience in enzyme technology, in immobilization techniques (aiming the reuse of the biocatalyst) and in the operation of membrane reactors for obtaining biotechnological products of interest to the pharmaceutical, chemical and food industries. Dr. Paul F. Long is Professor of Biotechnology at King's College London and Visiting International Research Professor at the University of São Paulo. He is a microbiologist by training and his research uses a combination of bioinformatics, laboratory and field studies to discover new medicines from nature, particularly from the marine environment.