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Phoenix Rising
by Karen HesseNyle Sumner is an orphan. And in spite of the fact that she and her grandmother live a good life on a Vermont sheep farm, she cannot forget that her father abandoned her. She cannot forget that her mother died in the back room of the farmhouse when Nyle was six. And she cannot forget that her grandfather died in that same room, just a few years ago. When there's an explosion at a nearby nuclear plant, a woman and her fifteen-year-old son seek refuge in Nyle's house. Ezra Trent has been severely poisoned with radiation, and Nyle is sure that he will die in the back room, just like the others. She'd rather not get to know him; rather not let his death affect her. But somehow inside, Nyle knows she must try to help this person--that his life depends on it.
Phoenix Rising (Phoenix Ser. #1)
by Bryony PearceSail. Salvage. Repeat.For as long as Toby can remember, he and his father have sailed on the Phoenix, salvaging from the junk-filled seas to stay afloat, while keeping under the radar of the authorities. His father is, after all, a wanted man.And now the Phoenix is on the trail of the ultimate prize: a salvage of solar panels that could mean they’ll never need to hunt for fuel again.Ayla is second-in-command on the rival Banshee, where she’s trained her whole life to fight-just as her mother, Captain Nell, demands. Since childhood, Ayla’s been taught the Phoenix must be destroyed. With the ship in their sights, her crew is desperate to have the precious intel, too.Toby’s sick of a life at sea, and Ayla may be his only hope. Can he turn an old feud into a new alliance that will save both their skins?Award-winning author Bryony Pearce brings the high seas to life with her rousing steampunk pirate adventure that will have you craving more.
Phoenix Zones: Where Strength Is Born and Resilience Lives
by Hope FerdowsianFew things get our compassion flowing like the sight of suffering. But our response is often shaped by our ability to empathize with others. Some people respond to the suffering of only humans or to one person’s plight more than another’s. Others react more strongly to the suffering of an animal. These divergent realities can be troubling—but they are also a reminder that trauma and suffering are endured by all beings, and we can learn lessons about their aftermath, even across species. With Phoenix Zones, Dr. Hope Ferdowsian shows us how. Ferdowsian has spent years traveling the world to work with people and animals who have endured trauma—war, abuse, displacement. Here, she combines compelling stories of survivors with the latest science on resilience to help us understand the link between violence against people and animals and the biological foundations of recovery, peace, and hope. Taking us to the sanctuaries that give the book its title, she reveals how the injured can heal and thrive if we attend to key principles: respect for liberty and sovereignty, a commitment to love and tolerance, the promotion of justice, and a fundamental belief that each individual possesses dignity. Courageous tales show us how: stories of combat veterans and wolves recovering together at a California refuge, Congolese women thriving in one of the most dangerous places on earth, abused chimpanzees finding peace in a Washington sanctuary, and refugees seeking care at Ferdowsian’s own medical clinic. These are not easy stories. Suffering is real, and recovery is hard. But resilience is real, too, and Phoenix Zones shows how we can foster it. It reveals how both people and animals deserve a chance to live up to their full potential—and how such a view could inspire solutions to some of the greatest challenges of our time.
Phoma: Diversity, Taxonomy, Bioactivities, and Nanotechnology
by Mahendra Rai Beata Zimowska György János KövicsThe book covers the taxonomy, diversity, bioactivity, and nanotechnology involved in the study of the genus Phoma. It presents the most recent molecular taxonomic approach, secondary metabolites, different bioactivities, combating microbial threats, and its use in nanotechnology from a basic research to an applied perspective. Expert contributors provide the latest research and applications to present thorough coverage of this important genus in human and plant pathology and the disease management.
Phone-y Friends (Project Droid)
by Nancy Krulik Amanda Burwasser Mike MoranLogan auditions for the school play and is chosen for the role of Chipmunk Number Three, but unfortunately, Java, Logan's robot cousin, doesn't get a part, which means he and Logan won't be hanging out together every day after school. Logan's excited to have something to himself and starts spending more and more time with his new friends.Now with so much time on his hands, Java is determined to make some new friends, too--the dishwasher, the electric mixer, the refrigerator . . . But his favorite new friend is Spike, the voice activated program on Mrs. Applebaum's cell phone. While Java can't be in the play, he ends up helping out with building the sets, and almost blows his cover! But when Logan freezes and forgets his lines on stage, and Java (who has memorized them in an instant) feeds them to him the Cyrano-style, it's the android who saves the day. After all, that's what friends are for.Internationally bestselling author Nancy Krulik and her incredibly talented daughter, Amanda Burwasser, spin hilarious high jinks in the fourth book in the Project Droid series, which combines the literalness of Amelia Bedelia with a wacky modern edge, making for hours of laughter. And the fun continues with an activity in the back!
Phones Keep Us Connected (Let's-Read-and-Find-Out Science 2)
by Kathleen Weidner ZoehfeldRead and find out about the science, technology, and history of how phones work in this colorfully illustrated nonfiction picture book."A well-explained, informative presentation on the telephone’s historical development as well as how cell phones work. Featuring a diverse crew of characters, the upbeat digital illustrations are attractive and, equally important, very helpful in showing hard-to-visualize concepts." (Booklist starred review)Phones Keep Us Connected includes a glossary, a find out more section with an activity about building a string telephone, and an infographic about the history of the phone.Questions addressed in this book include:How was the phone invented?How has it changed?How can a phone carry your voice across oceans?Read and find out in the proven winner Phones Keep Us Connected!This is a Level 2 Let's-Read-and-Find-Out, which means the book explores more challenging concepts for children in the primary grades. The 100+ titles in this leading nonfiction series are:hands-on and visualacclaimed and trustedgreat for classroomsTop 10 reasons to love LRFOs:Entertain and educate at the same timeHave appealing, child-centered topicsDevelopmentally appropriate for emerging readersFocused; answering questions instead of using survey approachEmploy engaging picture book quality illustrationsUse simple charts and graphics to improve visual literacy skillsFeature hands-on activities to engage young scientistsMeet national science education standardsWritten/illustrated by award-winning authors/illustrators & vetted by an expert in the fieldOver 130 titles in print, meeting a wide range of kids' scientific interestsBooks in this series support the Common Core Learning Standards, Next Generation Science Standards, and the Science, Technology, Engineering, and Math (STEM) standards. Let's-Read-and-Find-Out is the winner of the American Association for the Advancement of Science/Subaru Science Books & Films Prize for Outstanding Science Series.
Phonological Disorders in Children: Theory, Research and Practice (Psychology Library Editions: Speech and Language Disorders)
by Mehmet S. YavasOriginally published in 1991, the recent developments in the study of phonological disorders in children had led to a fruitful interaction between speech pathology and phonology. It is one aspect of the application of linguistic theory to the study of speech and language disorders which had opened up a new field, clinical linguistics. This book brings together the concerns of the linguist and the speech pathologist; the essays chosen share the quality of not discussing theory or therapy without addressing the implications one has for the other. By concentrating on recent work the editor hoped to stimulate further discussion in this important and fast growing area of research.
Phonon Thermal Transport in Silicon-Based Nanomaterials (SpringerBriefs in Physics)
by Hai-Peng Li Rui-Qin ZhangIn this Brief, authors introduce the advance in theoretical and experimental techniques for determining the thermal conductivity in nanomaterials, and focus on review of their recent theoretical studies on the thermal properties of silicon–based nanomaterials, such as zero–dimensional silicon nanoclusters, one–dimensional silicon nanowires, and graphenelike two–dimensional silicene. The specific subject matters covered include: size effect of thermal stability and phonon thermal transport in spherical silicon nanoclusters, surface effects of phonon thermal transport in silicon nanowires, and defects effects of phonon thermal transport in silicene. The results obtained are supplemented by numerical calculations, presented as tables and figures. The potential applications of these findings in nanoelectrics and thermoelectric energy conversion are also discussed. In this regard, this Brief represents an authoritative, systematic, and detailed description of the current status of phonon thermal transport in silicon–based nanomaterials. This Brief should be a highly valuable reference for young scientists and postgraduate students active in the fields of nanoscale thermal transport and silicon-based nanomaterials.
Phononic and Electronic Excitations in Complex Oxides Studied with Advanced Infrared and Raman Spectroscopy Techniques (Springer Theses)
by Fryderyk LyzwaThis PhD thesis reports on investigations of several oxide-based materials using advanced infrared and Raman spectroscopy techniques and in combination with external stimuli such as high magnetic or electric field, sptial confinement in thin film heterostructures and the radiation with UV light. This leads to new results in the fields of superconductivity, electronic polarization states and nanoscale phenomena.Among these, the observation of anomalous polar moments is of great relevance for understanding the electric-field-induced metal-to-insulator transistion; and the demonstration that confocal Raman spectroscopy of backfolded acoustic photons in metal-oxide multilayers can be used as a powerful characterization tool for monitoring their interface properties and layer thickness is an important technical development for the engineering of such functional oxide heterostructures.
Phononic Crystals
by Abdelkrim Khelif Ali AdibiThis book provides an in-depth analysis as well as an overview of phononic crystals. This book discusses numerous techniques for the analysis of phononic crystals and covers, among other material, sonic and ultrasonic structures, hypersonic planar structures and their characterization, and novel applications of phononic crystals. This is an ideal book for those working with micro and nanotechnology, MEMS (microelectromechanical systems), and acoustic devices. This book also: Presents an introduction to the fundamentals and properties of phononic crystals Covers simulation techniques for the analysis of phononic crystals Discusses sonic and ultrasonic, hypersonic and planar, and three-dimensional phononic crystal structures Illustrates how phononic crystal structures are being deployed in communication systems and sensing systems
Phosphatase Modulators
by José Luis MillánDriving further the research on mammalian alkaline phosphatase structure and function, Phosphatase Modulators collects expert contributions into one "how to" manual for basic scientists interested in initiating a drug discovery effort. While this book contains the traditional method chapters and some typical reviews on the structure and known functions of phosphatases, other contributions are meant to discuss approaches and alternatives useful in making "go/no-go" decisions in high throughput screening (HTS) and lead optimization campaigns. Many chapters focus on tissue-nonspecific alkaline phosphatase (TNAP) as well as protein phosphatases. Written for the highly successful Methods in Molecular Biology series, chapters in this volume include the kind of detail and key implementation advice that promotes reproducible results. Step-by-step and practical, Phosphatase Modulators offers a path to understanding many of the facets and complexities associated with undertaking a drug discovery effort and will serve as a roadmap to initiating those efforts.
Phosphate in Soils: Interaction with Micronutrients, Radionuclides and Heavy Metals (Emergent Environmental Pollution)
by H. Magdi SelimEdited by One of the Best Specialists in Soil ScienceRecent studies reveal that Phosphorus (P) in the form of phosphate, a macronutrient essential for plant growth, and crop yields can influence the bioavailability, retention, and mobility of trace elements, metal(loid)s, and radio nuclides in soils. When this occurs, phosphates can affect the dynamics of heavy metals and influence soil characteristics, impacting soil mobility and toxicity. Phosphate in Soils: Interaction with Micronutrients, Radionuclides and Heavy Metals utilizes the latest research to emphasize the role that phosphate plays in enhancing or reducing the mobility of heavy metals in soil, and the soil-water-plant environment. It provides an in-depth understanding of each heavy metal species, and expands on phosphate interactions in geological material.Composed of 12 chapters, this text: Provides an overview of the reactions of metal(loid)s and common P compounds that are used as fertilizer in soils Emphasizes the effect of phosphorus on copper and zinc adsorption in acid soils Discusses findings on the influence of phosphate compounds on speciation, mobility, and bioavailability of heavy metals in soils as well as the role of phosphates on in situ and phytoremediation of heavy metals for contaminated soils Places emphasis on the influence of phosphate on various heavy metals species in soils, and their solubility/mobility and availability Provides extensive information on testing various high phosphate materials for remediation of heavy metal, micronutrients, and radionuclides contaminated sites Explores the reactivity of heavy metals, micronutrients and radionuclides elements in several soils Presents a case study illustrating various remediation efforts of acidic soils and remediation of Cu, Zn, and lead (Pb) contaminated soils around nonferrous industrial plants Emphasizes the significance of common ions (cations and anions) on phosphate mobility and sorption in soils, and more The author includes analytical and numerical solutions along with hands-on applications, and addresses other topics that include the transport and sorption modeling of heavy metals in the presence of phosphate at different scales in the vadose zone.
Phosphate Phosphors for Solid-State Lighting
by H. C. Swart Kartik N. Shinde Kyeongsoon Park S. J. DhobleThe idea for this book arose out of the realization that, although excellent surveys and a phosphor handbook are available, there is no single source covering the area of phosphate based phosphors especially for lamp industry. Moreover, as this field gets only limited attention in most general books on luminescence, there is a clear need for a book in which attention is specifically directed toward this rapidly growing field of solid state lighting and its many applications. This book is aimed at providing a sound introduction to the synthesis and optical characterization of phosphate phosphor for undergraduate and graduate students as well as teachers and researchers. The book provides guidance through the multidisciplinary field of solid state lighting specially phosphate phosphors for beginners, scientists and engineers from universities, research organizations, and especially industry. In order to make it useful for a wide audience, both fundamentals and applications are discussed, together.
Phosphate Solubilizing Microorganisms
by Mohammad Saghir Khan Almas Zaidi Javed MusarratThis book provides a comprehensive description of phosphate solubilizing microorganisms and highlights methods for the use of microphos in different crop production systems. The focus is on understanding both the basic and applied aspects of phosphate solubilizing microorganisms and how phosphorus-deficient soils can be transformed into phosphorus-rich ones by applying phosphate solubilizing microorganisms. The interaction of rhizosphere phosphate solubilizing microorganisms and environmental variables, as well as their importance in the production of crops such as legumes, cereals, vegetables etc. are discussed and considered. The use of cold-tolerant phosphate solubilizing microorganisms to enhance crop productivity in mountainous regions is examined, as are the ecological diversity and biotechnological implications of phosphate solubilizing microorganisms. Lastly, the role of phosphate solubilizing microorganisms in aerobic rice cultivation is highlighted. This volume offers a broad overview of plant disease management using phosphate solubilizing microbes and presents strategies for the management of cultivated crops. It will therefore be of special interest to both academics and professionals working in the fields of microbiology, soil microbiology, biotechnology and agronomy, as well as the plant protection sciences. This timely reference book provides an essential and comprehensive source of material, as it includes recent findings on phosphate solubilizing microorganisms and their role in crop production.
Phosphates As Food Ingredients
by R.H. EllingerThere is an enormous quantity of literature, including numerous patents, on the functions and applications of phosphates in foods. No attempt has been made to review every publication, as such an exhaustive review would require a sizeable book. Anyone interested in further details on any topic covered in this treatise should consult the references listed at the end of the chapter. The bibliographies provided in the references for each topic should provide more thorough coverage. It is hoped that the references cited are those with the most useful information on the phosphate applications and their effects on foods.
Phosphatidylcholine Metabolism
by Dennis E. VanceThis book is the first to be published as a single source reference on phosphatidylcholine metabolism. It provides a cogent and timely summary of research in this topic.Beginning with a chapter by Eugene Kennedy providing an historical perspective; the book proceeds to describe the latest developments in enzymes involved in phosphatidylcholine biosynthesis. Biological chemists, students, and investigators in the field of lipid metabolism will find this book of great benefit in their research.
Phospho-Proteomics
by Marjo De GraauwProtein phosphorylation controls many basic cellular processes, such as cell growth, differentiation, migration, metabolism, and cell death, and its study can provide key insights into the signal transduction pathways that are activated in cells in response to different stimuli, such as growth factor stimulation or exposure to toxicants. In Phospho-Proteomics: Methods and Protocols, expert researchers contribute both well-established protocols and some of the newest strategies for the identification and evaluation of protein phosphorylation on Tyr, Ser, and Thr residues, including topics such as 2-dimensional gel electrophoresis and protein phosphorylation, enrichment of phospho-proteins and peptides, quantitative analysis of phosphorylation by labeling and MS analysis, and antibody and kinase arrays. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include brief introductions to their respective subjects, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Phospho-Proteomics: Methods and Protocols is an ideal reference for both new and experienced scientists who wish to gain insight into the current developments in the field and to find inspiration to pursue its future.
Phospho-Proteomics
by Louise StechowThis second edition provides up-to-date protocols focusing on techniques for the specific enrichment of phosphopeptides and phosphoproteins. Phosphoproteomics Methods and Protocols, Second Edition guides readers through different labeling strategies for quantitative phosphoproteomics; high-throughput mass spectrometry-based phosphoproteome analyses and phospho flow cytometry; and bioinformatics strategies for phosphoproteomics data analysis and integration. Additional protocols concentrate on the identification of kinase-substrate relationships by both high- and low-throughput approaches. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Phosphoproteomics Methods and Protocols, Second Edition aims to ensure successful results in the further study of this vital field.
Phosphodiesterase Methods and Protocols
by Claire LugnierResearch leaders in the PDE field describe new concepts and techniques for investigating the role of PDEs in orchestrating normal and pathophysiological responses. Presented in step-by-step detail, these readily reproducible methods allow the measurement of cyclic nucleotide variations in living cells, as well as their visualization in a spatio-temporal manner, the localization and characterization of their activities in tissues and living cells, and the assessment of targeted PDEs in creating specific tools and drugs. Additional chapters discuss the generation of PDE4 knockout mice to demonstrate not only the potential role of targeted PDEs, but also their use in further studies of the central role of PDE regulation in intracellular signaling control. These techniques offer clinicians a way to find new therapies for numerous pathologies whose molecular origins are unknown and whose treatment is symptomatic. Alterations of intracellular signaling related to PDE deregulation in such pathologies as inflammation, neurodegeneration, and cancer may explain the difficulties observed in their prevention and treatment.
Phosphodiesterases as Drug Targets
by Miles D. Houslay Sharron H. Francis Marco ContiCyclic nucleotide phosphodiesterases (PDEs) are promising targets for pharmacological intervention. Multiple PDE genes, isoform diversity, selective expression and compartmentation of the isoforms, and an array of conformations of PDE proteins are properties that challenge development of drugs that selectively target this class of enzymes. Novel characteristics of PDEs are viewed as unique opportunities to increase specificity and selectivity when designing novel compounds for certain therapeutic indications. This chapter provides a summary of the major concepts related to the design and use of PDE inhibitors.
Phosphoinositides: Methods and Protocols (Methods in Molecular Biology #2251)
by Roberto J. BotelhoThis detailed book examines experimental approaches used to investigate the regulation and function of phosphoinositides (PtdInsP), rare eukaryotic phospholipids with a broad role in biological processes such as signal transduction, cell migration and adhesion, cell growth, subcellular organization, and membrane trafficking. The combination of complementary biochemical, mass spectrometry, and imaging methods are instrumental for the detection and quantification of PtdInsP species, as well as induced dimerization methods, affinity precipitation or co-sedimentation with liposomes, protein insertion within lipid bilayers, and enzymatic assays, or through emerging methods like native mass spectrometry and microfluidics, all of which are touched upon in this volume. Written in the highly successful Methods in Molecular Biology format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Phosphoinositides: Methods and Protocols provides detailed methodology for both specialist and novice researchers on a variety of complementary methods that have been instrumental in dissecting the regulation, dynamics, and function of PtdInsPs.
Phosphoinositides I: Enzymes of Synthesis and Degradation
by Matthias Wymann John D. York Tamas BallaPhosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases - and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume I untangles the web of these enzymes and their products, and relates them to function in health and disease. Phosphoinositide 3-kinases and 3-phosphatases have received a special focus in volume I, and recent therapeutic developments in human disease are presented along with a historical perspective illustrating the impressive progress in the field.
Phosphoinositides II: The Diverse Biological Functions
by Matthias Wymann John D. York Tamas BallaPhosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases - and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume II extends into the role of phosphoinositides in membrane organization and vesicular traffic. Endocytosis and exocytosis are modulated by phosphoinositides, which determine the fate and activity of integral membrane proteins. Phosphatidylinositol(4,5)-bisphosphate is a prominent flag in the plasma membrane, while phosphatidylinositol-3-phosphate decorates early endosomes. The Golgi apparatus is rich in phosphatidylinositol-4-phosphate, stressed cells increase phosphatidylinositol(3,5)-bisphosphate, and the nucleus has a phosphoinositide metabolism of its own. Phosphoinositide-dependent signaling cascades and the spatial organization of distinct phosphoinositide species are required in organelle function, fission and fusion, membrane channel regulation, cytoskeletal rearrangements, adhesion processes, and thus orchestrate complex cellular responses including growth, proliferation, differentiation, cell motility, and cell polarization.
Phospholipases in Health and Disease
by Paramjit S. Tappia Naranjan S. DhallaPhospholipases generate lipid signaling molecules through their hydrolytic action on phospholipids and are known to regulate function of a variety of cells under normal and diseased conditions. While several physiological, biochemical and molecular techniques have identified key players involved in different disease processes, phospholipases have also emerged as critical players in the pathogenesis of a number of different diseases including cancer and heart disease. In addition, phospholipases are also implicated in such conditions as brain disorder/injury, kidney and immune cell dysfunction. Phospholipases in Health and Disease is a compilation of review articles dedicated to the study of the field with respect to biochemical and molecular mechanisms of normal and abnormal cell function. The wide range of area covered here is of interest to basic research scientists, clinicians and graduate students, who are engaged in studying pathophysiological basis of a variety of diseases. Furthermore, this book highlights the potential of the different phospholipases as therapeutic targets as well as part of prevention strategies. Twenty three articles in this book are organized in four sections that are designed to emphasize the most characterized forms of the phospholipases in mammalian cells. The first section discusses general aspect of phospholipases. Section two covers the role and function of phospholipase A in different pathophysiological conditions. The third section is focussed on phospholipase C which is believed to play a central role in transmembrane signaling. The final section covers phospholipase D which is present in a variety of different cells. The book illustrates that the activation of phospholipases is of fundamental importance in signal transduction affecting cell function. Overall, this book discusses the diverse mechanisms of phospholipase mediated signal transduction in different pathophysiological conditions and raises the possibility of specific forms of phospholipases serving as novel targets for drug development.
Phospholipases in Plant Signaling
by Xuemin WangThis volume focuses on recent advances in the biochemical and molecular analysis of different families of phospholipases in plants and their roles in signaling plant growth, development and responses to abiotic and biotic cues. The hydrolysis of membrane lipids by phospholipases produces different classes of lipid mediators, including phosphatidic acid, diacylglycerol, lysophospholipids, free fatty acids and oxylipins. Phospholipases are grouped into different families and subfamilies according to their site of hydrolysis, substrate usage and sequence similarities. Activating one or more of these enzymes often constitutes an early, critical step in many regulatory processes, such as signal transduction, vesicular trafficking, secretion and cytoskeletal rearrangements. Lipid-based signaling plays pivotal roles in plant stress responses, cell size, shape, growth, apoptosis, proliferation, and reproduction.