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Plant and Animal Relationships: Investigation Notebook
by The Lawrence Hall of ScienceNIMAC-sourced textbook
Plant and Animal Structures
by Linda CernakAnimal Structures, Plant Structures, Science and Engineering Practices, Careers.
Plant and Food Carotenoids: Methods and Protocols (Methods in Molecular Biology #2083)
by Manuel Rodríguez-Concepción Ralf WelschThis volume provides a comprehensive compilation of techniques and protocols used in plant and food carotenoid research. Chapters guide readers through seven major areas on core enzyme activities, analysis of carotenoid profiles, new imaging tools, synthesis and degradation dynamics, biotechnology, nutrition, and health. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Plant and Food Carotenoids: Methods and Protocols aims to be helpful to researchers of other disciplines that are impacted by carotenoids, including photosynthesis, biotechnology, food science, and nutrition.
Plant and Human Health, Volume 1: Ethnobotany and Physiology
by Khalid Rehman Hakeem Munir OzturkEarly anthropological evidence for plant use as medicine is 60,000 years old as reported from the Neanderthal grave in Iraq. The importance of plants as medicine is further supported by archeological evidence from Asia and the Middle East. Today, around 1.4 billion people in South Asia alone have no access to modern health care, and rely instead on traditional medicine to alleviate various symptoms. On a global basis, approximately 50 to 80 thousand plant species are used either natively or as pharmaceutical derivatives for life-threatening conditions that include diabetes, hypertension and cancers. As the demand for plant-based medicine rises, there is an unmet need to investigate the quality, safety and efficacy of these herbals by the “scientific methods”. Current research on drug discovery from medicinal plants involves a multifaceted approach combining botanical, phytochemical, analytical, and molecular techniques. For instance, high throughput robotic screens have been developed by industry; it is now possible to carry out 50,000 tests per day in the search for compounds, which act on a key enzyme or a subset of receptors. This and other bioassays thus offer hope that one may eventually identify compounds for treating a variety of diseases or conditions. However, drug development from natural products is not without its problems. Frequent challenges encountered include the procurement of raw materials, the selection and implementation of appropriate high-throughput bioassays, and the scaling-up of preparative procedures. Research scientists should therefore arm themselves with the right tools and knowledge in order to harness the vast potentials of plant-based therapeutics. The main objective of Plant and Human Health is to serve as a comprehensive guide for this endeavor. Volume 1 highlights how humans from specific areas or cultures use indigenous plants. Despite technological developments, herbal drugs still occupy a preferential place in a majority of the population in the third world and have slowly taken roots as alternative medicine in the West. The integration of modern science with traditional uses of herbal drugs is important for our understanding of this ethnobotanical relationship. Volume 2 deals with the phytochemical and molecular characterization of herbal medicine. Specifically, it focuess on the secondary metabolic compounds, which afford protection against diseases. Lastly, Volume 3 discusses the physiological mechanisms by which the active ingredients of medicinal plants serve to improve human health. Together this three-volume collection intends to bridge the gap for herbalists, traditional and modern medical practitioners, and students and researchers in botany and horticulture.
Plant and Human Health, Volume 2: Phytochemistry And Molecular Aspects
by Munir Ozturk Khalid Rehman HakeemEarly anthropological evidence for plant use as medicine is 60,000 years old as reported from the Neanderthal grave in Iraq. The importance of plants as medicine is further supported by archeological evidence from Asia and the Middle East. Today, around 1.4 billion people in South Asia alone have no access to modern health care, and rely instead on traditional medicine to alleviate various symptoms. On a global basis, approximately 50 to 80 thousand plant species are used either natively or as pharmaceutical derivatives for life-threatening conditions that include diabetes, hypertension and cancers. As the demand for plant-based medicine rises, there is an unmet need to investigate the quality, safety and efficacy of these herbals by the “scientific methods”. Current research on drug discovery from medicinal plants involves a multifaceted approach combining botanical, phytochemical, analytical, and molecular techniques. For instance, high throughput robotic screens have been developed by industry; it is now possible to carry out 50,000 tests per day in the search for compounds which act on a key enzyme or a subset of receptors. This and other bioassays thus offer hope that one may eventually identify compounds for treating a variety of diseases or conditions. However, drug development from natural products is not without its problems. Frequent challenges encountered include the procurement of raw materials, the selection and implementation of appropriate high-throughput bioassays, and the scaling-up of preparative procedures. Research scientists should therefore arm themselves with the right tools and knowledge in order to harness the vast potentials of plant-based therapeutics. The main objective of Plant and Human Health is to serve as a comprehensive guide for this endeavor. Volume 1 highlights how humans from specific areas or cultures use indigenous plants. Despite technological developments, herbal drugs still occupy a preferential place in a majority of the population in the third world and have slowly taken roots as alternative medicine in the West. The integration of modern science with traditional uses of herbal drugs is important for our understanding of this ethnobotanical relationship. Volume 2 deals with the phytochemical and molecular characterization of herbal medicine. Specifically, It will focus on the secondary metabolic compounds which afford protection against diseases. Lastly, Volume 3 focuses on the physiological mechanisms by which the active ingredients of medicinal plants serve to improve human health. Together this three-volume collection intends to bridge the gap for herbalists, traditional and modern medical practitioners, and students and researchers in botany and horticulture.
Plant and Human Health, Volume 3: Pharmacology And Therapeutic Uses
by Munir Ozturk Khalid Rehman HakeemEarly anthropological evidence for plant use as medicine is 60,000 years old as reported from the Neanderthal grave in Iraq. The importance of plants as medicine is further supported by archeological evidence from Asia and the Middle East. Today, around 1.4 billion people in South Asia alone have no access to modern health care, and rely instead on traditional medicine to alleviate various symptoms. On a global basis, approximately 50 to 80 thousand plant species are used either natively or as pharmaceutical derivatives for life-threatening conditions that include diabetes, hypertension and cancers. As the demand for plant-based medicine rises, there is an unmet need to investigate the quality, safety and efficacy of these herbals by the “scientific methods”. Current research on drug discovery from medicinal plants involves a multifaceted approach combining botanical, phytochemical, analytical, and molecular techniques. For instance, high throughput robotic screens have been developed by industry; it is now possible to carry out 50,000 tests per day in the search for compounds which act on a key enzyme or a subset of receptors. This and other bioassays thus offer hope that one may eventually identify compounds for treating a variety of diseases or conditions. However, drug development from natural products is not without its problems. Frequent challenges encountered include the procurement of raw materials, the selection and implementation of appropriate high-throughput bioassays, and the scaling-up of preparative procedures. <p><p>Research scientists should therefore arm themselves with the right tools and knowledge in order to harness the vast potentials of plant-based therapeutics. The main objective of Plant and Human Health is to serve as a comprehensive guide for this endeavor. Volume 1 highlights how humans from specific areas or cultures use indigenous plants. Despite technological developments, herbal drugs still occupy a preferential place in a majority of the population in the third world and have slowly taken roots as alternative medicine in the West. The integration of modern science with traditional uses of herbal drugs is important for our understanding of this ethnobotanical relationship. Volume 2 deals with the phytochemical and molecular characterization of herbal medicine. Specifically, it will focus on the secondary metabolic compounds which afford protection against diseases. Lastly, Volume 3 focuses on the physiological mechanisms by which the active ingredients of medicinal plants serve to improve human health. Together this three-volume collection intends to bridge the gap for herbalists, traditional and modern medical practitioners, and students and researchers in botany and horticulture.
Plant and Microbe Adaptations to Cold in a Changing World
by Ryozo Imai Midori Yoshida Naoyuki MatsumotoThis book includes papers from keynote lecture and oral presentations of Plant and Microbe Adaptations to Cold (PMAC) 2012, an international conference on winter hardiness of crop and pathogenic microbes. The PMAC has been started in 1997 in Japan as an interdisciplinary forum for scientists and extension people working in the field in plant pathology, plant physiology, microbiology, and crop breeding to increase our knowledge and improve our understanding of overwintering of crops, forages and grasses and solve the problems associated with losses due to freezing and heavy snow cover. Successive meetings have been held in Iceland (2000), Canada (2003), Italy (2006), and Norway (2009). PMAC2012 will be a special meeting with a focus on global climate change, food security and agriculture sustainability and the whole program will be arranged to reflect this theme. The topics covered by this proceedings includes, global warming in agricultural environment, plant adaptations to cold, microbial adaptations to cold, plant-microbe interaction under cold, and molecular breeding for winter hardiness. The researches range from molecular biology to ecology and breeding. Experts in the field will report cutting edge research and thoughtful strategies for sustainability.
Plant and Nanoparticles
by Jen-Tsung ChenThis book explores the interactions between nanomaterials/nanoparticles and plants and unveils potential applications. The chapters emphasize the implications of nanoparticles in cross-discipline approaches, including agricultural science, plant physiology, plant biotechnology, material science, environmental science, food chemistry, biomedical science, etc. It presents recent advances in experimental and theoretical studies and gives in-depth insights into the interaction between nanoparticles and plant cells. In addition, it discusses the potential applications and concerns of nanoparticles comprehensively. The research field of plant nanotechnology has great potential within plant sciences and agriculture and the related research is getting increased at present. The study of plant nanotechnology receives an advantage from the great progress of nanotechnology in biomedical sciences particularly the well-development of a variety of biocompatible nanoparticles (NPs) and advanced analytical techniques. Nowadays, although some NPs have been applied in the studies of plant and agronomic sciences, the knowledge regarding physiology and underlying mechanisms within the plant cell remains limited. This book offers a critical reference for students, teachers, professionals, and a wide array of researchers in plant science, plant physiology, plant biotechnology, material science, environmental science, food chemistry, nanotechnology, and biomedical science. It could also benefit the related field of plant nanotechnology for designing and organizing future research.
Plant and Soil Science: Fundamentals and Applications
by Rick ParkerThis book combines the basic knowledge of plant and soil science, in an easy to read and teach format, and provides practical real world application for information learned. Organized into twenty-eight chapters, each chapter features learning objectives, key terms, tables, charts, illustrations and color photographs to aid the learning and teaching process.
Plant and Vegetation Mapping
by Franco PedrottiThe book is concerned principally with geobotanical mapping. Geobotany is a broad science that deals with the study of species and of vegetation communities in relation to the environment; it includes other, perhaps more familiar sciences, such as plant geography, plant ecology, and chorology, and phytosociology (plant sociology). Geobotanical cartography is a field of thematic cartography that deals with the interpretation and representation, in the form of maps, of those spatial and temporal phenomena that pertain to flora, vegetation, vegetated landscapes, vegetation zones, and phytogeographical units. The production of a geobotanical map represents the last stage in a cognitive process that begins with observations in the field and continues with the collection of sample data, interpretation of the phenomena observed, and their appropriate cartographic representation; geobotanical cartography is closely tied to the concepts and scope of geobotany in general
Plant-Animal Interactions: Source of Biodiversity
by Kleber Del-Claro Helena Maura Torezan-SilingardiThis textbook provides the first overview of plant-animal interactions for twenty years focused on the needs of students and professors. It discusses a range of topics from the basic structures of plant-animal interactions to their evolutionary implications in producing and maintaining biodiversity. It also highlights innovative aspects of plant-animal interactions that can represent highly productive research avenues, making it a valuable resource for anyone interested in a future career in ecology. Written by leading experts, and employing a variety of didactic tools, the book is useful for students and teachers involved in advanced undergraduate and graduate courses addressing areas such as herbivory, trophic relationships, plant defense, pollination and biodiversity.
Plant Antioxidants and Health (Reference Series in Phytochemistry)
by Halina Maria Ekiert Kishan Gopal Ramawat Jaya AroraThis book provides a comprehensive reference guide to plant-derived antioxidants, their beneficial effects, mechanisms of action, and role in disease prevention and improving general health (anti-ageing effect). The content is divided into three main parts, the first of which covers various antioxidants (such as polyphenols, carotenoids, tocopherols, tocotrienols, glutathione, ascorbic acid), their origins, plant biochemistry and industrial utilization. In turn, the book’s second, main part focuses on antioxidants’ beneficial health effects, explains biochemical fundamentals such as the free radical theory and oxidative stress, and discusses antioxidants’ role in e.g. cancer, cardiovascular diseases, inflammation, degenerative diseases and ageing. The third part reviews general laboratory methods for antioxidant screening, preservation and determination. Written by an international team of experts, this highly interdisciplinary book will benefit a broad range of health professionals and researchers working in biochemistry, biotechnology, nutrition, plant science and food chemistry. It offers an indispensable, up-to-date guide for anyone interested in antioxidants and the role of a plant-based diet in disease prevention and control
Plant Aquaporins
by François Chaumont Stephen D. TyermanAquaporins are channel proteins that facilitate the diffusion of water and small uncharged solutes across cellular membranes. Plant aquaporins form a large family of highly divergent proteins that are involved in many different physiological processes. This book will summarize the recent advances regarding plant aquaporins, their phylogeny, structure, substrate specificity, mechanisms of regulation and roles in various important physiological processes related to the control of water flow and small solute distribution at the cell, tissue and plant levels in ever-changing environment.
Plant Argonaute Proteins
by Alberto CarbonellThis volume provides the reader with step-by-step methods to study plant ARGONAUTE (AGO) functions. Chapters in Plant Argonaute Poteins: Methods and Protocols summarize the main biochemical, molecular and cytological methods to study AGO-small RNA complexes and their interactions with target RNAs, AGO subcellular localization, AGO association with polysomes, AGO role in meiosis and DNA repair, methods for the identification, cloning and characterization of AGO genes in different plant species, and non-radioactive protocols for small RNA detection. Finally, a series of chapters describing computational methods to study plant AGO function and evolution are provided. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Plant Argonaute Proteins: Methods and Protocols aims to deliver the most complete and updated list of protocols to study plant AGO function.
Plant-based Foods and their Implications in Brain Health
by Soumya Mukherjee Akula Ramakrishna Atanu BhattacharjeePhytoconstituents are a valuable source of new lead compounds due to their structural variety.The accelerated rate of human ageing brought about by the 21st century's longer life expectancy seems to be one of the major problems facing varied cultures worldwide. Ageing and the onset of chronic diseases appear to be significantly influenced by the type of food consumption pattern that people follow throughout their lives. There is strong evidence that Mediterranean diets are linked to a lower risk of brain disorders. A greater proportion of rural communities in the Mediterranean basin eat a diet high in plant-based foods daily. Stressors like reactive oxygen and reactive nitrogen species have a major negative influence on the brain in addition to the cardiovascular system.Foods, particularly those derived from plants, are a great source of vitamins, antioxidants, polyphenols, and vital fatty acids, according to a growing body of epidemiological research. Studies indicate the effect of antioxidant vitamins on brain health, including ascorbic acid and α-tocopherol. Polyphenols and other plant-derived bioactivities influence how animal and human brains operate by reducing the amount of oxidative stress and controlling different signal transduction pathways, according to a large body of experimental evidence.The present volume provides a collation of recent developments in the field with special reference to various types of plant-based phytoconstituents. The book's content is relevant and interesting to a wide range of audiences from the backgrounds of plant sciences, pharmacy, biochemistry, and molecular biology. Apart from being a good reference material source, the book is relevant to plant biotechnologists and students/researchers in the field.
Plant-Based Foods: Ingredients, Technology and Health Aspects
by Alev Yüksel AydarThe plant-based food industry has flourished in recent years, with a steady stream of exciting product launches reaching the worldwide market. Consumers have become interested in a plant-based diet that includes grains, legumes, seeds, nuts, fruits and vegetables. There are a number of factors involved in this trend, including consumer opposition to harming animals, health problems such as lactose intolerance, desire for a healthier lifestyle and environmental awareness. Several books related to plant-based diets and cookbooks have been published for vegans and vegetarians, however there is no research work related to plant-based production, technology, ingredients and their qualitative and nutritional properties based on the results of scientific studies. Future Food: Plant-Based Products is the first book where the comparison of plant-based products with other alternatives are explored in detail. Novel plant-based product formulations, production and results of recent studies are examined in detail in this book. Plant-based products are mainly alternatives to dairy and meat products, and this text includes comprehensive chapters on meat substitutes and plant-based non-dairy products. In the opening chapter the main ingredients and raw materials used to produce a variety of plant-based products are covered along with their qualitative and nutritional properties. Further chapters focus on the health effects of plant-based products and microbiological and safety issues. For researchers seeking a full, up-to-date overview of plant-based product alternatives and their production, health affects and safety aspects, this book meets your needs.
Plant-Based Functional Foods and Phytochemicals: From Traditional Knowledge to Present Innovation (Innovations in Plant Science for Better Health)
by Megh R. Goyal Arijit Nath Hafiz Ansar Rasul SuleriaPlant-Based Functional Foods and Phytochemicals: From Traditional Knowledge to Present Innovation covers the importance of the therapeutic health benefits of phytochemicals derived from plants. It discusses the isolation of potential bioactive molecules from plant sources along with their value to human health. It focuses on physical characteristics, uniqueness, uses, distribution, traditional and nutritional importance, bioactivities, and future trends of different plant-based foods and food products. Functional foods, beyond providing basic nutrition, may offer a potentially positive effect on health and cures for various disease conditions, such as metabolic disorders (including diabetes), cancer, and chronic inflammatory reactions. The volume looks at these natural products and their bioactive compounds that are increasingly utilized in preventive and therapeutic medications and in the production of pharmaceutical supplements and as food additives to increase functionality. It also describes the concept of extraction of bioactive molecules from plant sources, both conventional and modern extraction techniques, available sources, biochemistry, structural composition, and potential biological activities.
Plant Based “Green Chemistry 2.0”: Moving from Evolutionary to Revolutionary (Green Chemistry and Sustainable Technology)
by Ying Li Farid ChematThis book provides practical information on obtaining and using a wide variety of plant based reagents for different sectors, addressing the needs and challenges in a single resource. The chapters complement each other seamlessly and present contributions from reputed international researchers and renowned professionals from industry, covering the latest efforts in the field. The book serves as the starting point for future collaborations in the new area “Plant Based Green Chemistry” between research, industry, and education, covering large ecologic and economic applications: perfume, cosmetic, pharmaceutical, food ingredients, nutraceuticals, biofuels, or fine chemicals industries. This book is aimed at professionals from industries, academicians engaged in plant based green chemistry, researchers and graduate level students, but will also be useful to food technologists and students and researchers involved in natural products chemistry.
Plant-Based Nanoparticle Synthesis for Sustainable Agriculture
by Ranjit Pabbati Kalyani Chepuri Kondakindi Venkateswar Reddy Naga Raju MaddelaThe use of nanotechnology in agriculture has created many concerns related to toxicity and environmental implications. Green synthesis techniques for producing nanomaterials utilizing plants, microorganisms, and other natural resources have been developed in response to the demand for green chemistry and nanotechnology. This book provides in-depth information on the plant-based synthesis of nanoparticles and how it promotes sustainable agriculture. It critically reviews nanomaterials synthesized from plants and their potential applications, including nanoscale insecticides, herbicides, fungicides, fertilizers, and sensors, which can help to study and manage plant health and soil fertility.The features of this volume include: A comprehensive resource on plant-based nanoparticle synthesis and its usage in gene transformation; Strategies and limitations of plants that are genetically engineered using nanotechnology; Explanation of the design and use of nanofertilizers and nonopesticides for environmental sustainability; Discussions around the toxicity levels of nanoparticles in plants; Aids for professionals and scholars to learn advanced techniques to monitor soil and plant systems using nanotechnology. This is an excellent reference for researchers, academics, students, and professionals in nanotechnology, biochemistry, biomedical sciences, biotechnology, environmental engineering, agricultural sciences, and plant sciences.
Plant-Based Natural Products: Derivatives and Applications
by Shahid Ul-IslamIntense research has been started all around the world in the past few decades to exploit different agents from natural products as eco-friendly alternative to synthetic and toxic chemicals. Natural products and their derivatives have received increasing attention for their use in many everyday applications ranging from food, medicine, textiles, and healthcare.This new book presents significant research advances about the use of natural products, mainly plant colorants, bioactive compounds and other plant extracts in the textile coloration, food, bioremediation and environmental applications. There are total eight chapters contributed by leading researchers covering the topics such as potential resurgence of natural dyes in applied fields, natural colorants from indigoid plants, phytochemistry of dye yielding plants, irradiation as novel pretreatment methods, dyeing studies with henna plant, phytoremediation of arsenic, and synthesis of curcumin complexes for medicinal and other industrial uses.
Plant-Based Remediation Processes
by Dharmendra Kumar GuptaPhytoremediation is an emerging technology that employs higher plants for the clean-up of contaminated environments. Basic and applied research have unequivocally demonstrated that selected plant species possess the genetic potential to accumulate, degrade, metabolize and immobilize a wide range of contaminants. The main focus of this volume is on the recent advances of technologies using green plants for remediation of various metals and metalloids. Topics include biomonitoring of heavy metal pollution, amendments of higher uptake of toxic metals, transport of heavy metals in plants, and toxicity mechanisms. Further chapters discuss agro-technological methods for minimizing pollution while improving soil quality, transgenic approaches to heavy metal remediation and present protocols for metal remediation via in vitro root cultures.
Plant-Based Therapeutics, Volume 1: Cannabis sativa
by Ivan A. RossBy examining historical applications of the compounds found in plants, this five-volume series serves as a reference for quality assurance, research, product development, and regulatory guidance of the compounds found in plant-based medicines. This work supports the growing consumers' interest in herbal medicine for wellness and health. Plant-Based Therapeutics, Volume 1: Cannabis sativa, the first in the series, covers a unique plant species and provides the framework to integrate its evidence-based scientific discoveries with healthcare therapies. Cannabis has been used in religious ceremonies and medical purposes for thousands of years. Cannabidiol (CBD), the main non-psychoactive component of Cannabis, was isolated in the 1940s, and its structure was established in the 1960s. In 1964 tetrahydrocannabinol (THC), the psychoactive component, was isolated. Cannabis has more than 500 components, of which 104 cannabinoids have been identified. Two of them, THC and CBD, have been the primary components of scientific investigations. They were approved by the FDA for chemotherapy-induced nausea and vomiting in 1985; for appetite stimulation in wasting conditions, such as AIDS, in 1992, and in 2018 for treating two forms of pediatric epilepsy, Dravet syndrome and Lennox-Gastaut syndrome. Beyond the indications for which cannabinoids are FDA-approved, the evidence reveals that cannabinoid receptors are present throughout the body, embedded in cell membranes, and are believed to be more numerous than any other receptor system. When cannabinoid receptors are stimulated, a variety of physiologic processes ensue. Thus, other constituents of Cannabis are extremely promising either as individual compounds or their potential synergistic or entourage effects in the treatment of numerous medical conditions.
Plant-Based Therapeutics, Volume 2: The Brassicaceae Family
by Ivan A. RossFor centuries, research has been conducted on the therapeutics of Brassicaceae plants and their health-promoting effects. Cato the Elder (234-149 BCE) documented their properties in his work De agri cultura and recommended using cabbage to compress wounds, swelling, burns, and bone dislocations. For arthritis, he recommended chopped raw cabbage mixed with coriander and cured cabbage mixed with vinegar and honey. In a groundbreaking discovery in the 1990s, scientists at Johns Hopkins University isolated sulforaphane from broccoli, revealing its potent anticancer properties. This naturally occurring compound has proven highly effective, safe, and tolerable and holds immense promise as a chemoprevention agent. It has the potential to combat various cancers, including breast, prostate, gastrointestinal, melanoma, lung, brain, and bladder. But its potential does not stop there. It also shows promise in treating cardiovascular and neurodegenerative diseases and diabetes, offering hope for those affected. The cancer-protecting properties of Brassica plants are mediated through compounds that induce a variety of physiological processes, including antioxidant action, detoxifying enzymes, inducing apoptosis, and cell cycle regulation. Glucosinolate breakdown products can affect several stages of cancer development, including the inhibition of activation enzymes (phase I) and the induction of detoxification enzymes (phase II). Isothiocyanates and indole products formed from glucosinolates regulate cancer cell development by regulating target enzymes, controlling apoptosis, inhibiting angiogenesis, metastasis, and the migration of cancer cells, and blocking the cell cycle. Sulforaphane, found in abundance in broccoli sprouts, plays a crucial role in upregulating the transcriptional activity of specific genes and restoring epigenetic alterations. This is particularly significant as it modifies epigenetic pathways by targeting histone deacetylases and DNA methyltransferases. These modifications, in turn, alter gene transcription and expression, particularly in the case of cancers. This intricate process of gene regulation is a fascinating study area, making broccoli sprouts a compelling component of the 'epigenetic diet.' Sulforaphane induces the cytoprotective enzyme NQO1. The inducible expression of NQO1 is regulated principally through the Keap1-Nrf2-ARE signaling pathway. The activation of the Nrf2-Keap1 signaling pathway heralds the beneficial actions of drugs known to affect Nrf2 signaling, such as dimethyl fumarate, an FDA-approved treatment for multiple sclerosis, and bardoxolone methyl for chronic kidney disease. There is optimism that the overall strategies are moving forward. Sulforaphane-rich broccoli sprout extracts provide one avenue toward this end.
Plant Bioactives and Drug Discovery
by Valdir Cechinel-FilhoAn in-depth exploration of the applications of plant bioactive metabolites in drug research and development Highlighting the complexity and applications of plant bioactive metabolites in organic and medicinal chemistry, Plant Bioactives and Drug Discovery: Principles, Practice, and Perspectives provides an in-depth overview of the ways in which plants can inform drug research and development. An edited volume featuring multidisciplinary international contributions from acclaimed scientists researching bioactive natural products, the book provides an incisive overview of one of the most important topics in pharmaceutical studies today. With coverage of strategic methods of natural compound isolation, structural manipulation, natural products in clinical trials, quality control, and more, and featuring case studies on medicinal plants, the book serves as a definitive guide to the field of plant biodiversity as it relates to medicine. In addition, chapters on using natural products as drugs that target specific disease areas, including neurological disorders, inflammation, infectious diseases, and cancer, illustrate the myriad possibilities for therapeutic applications. Wide ranging and comprehensive, Plant Bioactives and Drug Discovery also includes important information on marketing, regulations, intellectual property rights, and academic-industry collaboration as they relate to plant-based drug research, making it an essential resource for advanced students and academic and industry professionals working in biochemical, pharmaceutical, and related fields.