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Showing 60,826 through 60,850 of 79,887 results

Purinergic Signaling in Neurodevelopment, Neuroinflammation and Neurodegeneration

by Henning Ulrich Peter Illes Talita Glaser

This volume explores the quickly evolving field of Purinergic signaling, and examines how receptors for ATP and other nucleotides, and receptors for adenosine, act in neuronal transmission, control of synaptic activity, proliferation, differentiation and cell death regulation in the CNS. This book focuses on the participation of purinergic receptors and ectonucleotidases, degrading ATP into adenosine, in embryonic and adult neurogenesis in vitro and in vivo as well as in synaptic transmission and pathophysiology. Further, the chapters discuss varying brain diseases, including Parkinson’s, and Alzheimer’s disease, autism, mood disorders and epilepsy, as well as brain tumors, in the context of purinergic signaling and its clinical aspects. The development of purinergic receptor agonists is also an important issue of this book. This book provides a critical review of the current state of science and will be useful for both scientists and students who are or would like to get involved in this area. Furthermore, this book addresses neuroscientists, physician and professionals from the industry, who would like to update themselves in this exciting and rapidly growing field of neuroscience.

Purple Pinchers and Other Hermit Crabs (World Book's Animals of the World)

by Sheri Reda

Topics in the book include how to care for a hermit crab, how it transfers from house to house, and how to care for one as a pet.

Purpose: What Evolution and Human Nature Imply about the Meaning of Our Existence

by Samuel T. Wilkinson

By using principles from a variety of scientific disciplines, Yale Professor Samuel Wilkinson provides a framework for human evolution that reveals an overarching purpose to our existence. Generations have been taught that evolution implies there is no overarching purpose to our existence, that life has no fundamental meaning. We are merely the accumulation of tens of thousands of intricate molecular accidents. Some scientists take this logic one step further, suggesting that evolution is intrinsically atheistic and goes against the concept of God. But is this true? By integrating emerging principles from a variety of scientific disciplines—ranging from evolutionary biology to psychology—Yale Professor Samuel Wilkinson provides a framework of evolution that implies not only that there is an overarching purpose to our existence, but what this purpose is. With respect to our evolution, nature seems to have endowed us with competing dispositions, what Wilkinson calls the dual potential of human nature. We are pulled in different directions: selfishness and altruism, aggression and cooperation, lust and love. When we couple this with the observation that we possess a measure of free will, all this strongly implies there is a universal purpose to our existence. This purpose, at least one of them, is to choose between the good and evil impulses that nature has created within us. Our life is a test. This is a truth, as old as history it seems, that has been espoused by so many of the world&’s religions. From a certain framework, these aspects of human nature—including how evolution shaped us—are evidence for the existence of a God, not against it. Closely related to this is meaning. What is the meaning of life? Based on the scientific data, it would seem that one such meaning is to develop deep and abiding relationships. At least that is what most people report are the most meaningful aspects of their lives. This is a function of our evolution. It is how we were created.

Purpose & Desire: What Makes Something "Alive" and Why Modern Darwinism Has Failed to Explain It

by J. Scott Turner

A professor, biologist, and physiologist argues that modern Darwinism’s materialist and mechanistic biases have led to a scientific dead end, unable to define what life is—and only an openness to the qualities of "purpose and desire" will move the field forward.Scott Turner contends. "To be scientists, we force ourselves into a Hobson’s choice on the matter: accept intentionality and purposefulness as real attributes of life, which disqualifies you as a scientist; or become a scientist and dismiss life’s distinctive quality from your thinking. I have come to believe that this choice actually stands in the way of our having a fully coherent theory of life." Growing research shows that life's most distinctive quality, shared by all living things, is purpose and desire: maintain homeostasis to sustain life. In Purpose and Desire, Turner draws on the work of Claude Bernard, a contemporary of Darwin revered among physiologists as the founder of experimental medicine, to build on Bernard’s "dangerous idea" of vitalism, which seeks to identify what makes "life" a unique phenomenon of nature. To further its quest to achieve a fuller understanding of life, Turner argues, science must move beyond strictly accepted measures that consider only the mechanics of nature. A thoughtful appeal to widen our perspective of biology that is grounded in scientific evidence, Purpose and Desire helps us bridge the ideological evolutionary divide.

The Purpose-Guided Universe: Believing in Einstein, Darwin, and God

by Bernard Haisch

“If you think that science has nothing to do with God, and vice versa, read this book—and you just may change your mind.” —Professor Peter Sturrock, Dept. Physics, Stanford UniversityIn this engrossing new book, Dr. Bernard Haisch contends that there is a purpose and an underlying intelligence behind the Universe, one that is consistent with modern science, especially the Big Bang and evolution. It is based on recent discoveries that there are numerous coincidences and fine-tunings of the laws of nature that seem extraordinarily unlikely.A more rational concept of God is called for. As astrophysicist Sir James Jeans wrote, “the Universe begins to look more like a great thought than like a great machine.”Despite bestsellers by Christopher Hitchens, Richard Dawkins, and Sam Harris that have denounced the evils of religion and proclaimed that science has shown that there is no God, The Purpose-Guided Universe shows how one can believe in God and science.“Committed atheists, traditional Christians, or hard-core Muslims will no doubt try to dismiss this book . . . provocative.” —Prof. Owen Gingerich, Harvard-Smithsonian Center for Astrophysics, author, God’s Universe“Neither science nor theology can consider itself informed without taking into account Haisch’s views.” —Larry Dossey, MD, author, Healing Words“Merits being read and pondered by everyone seeks deeper meaning underlying science’s ever more astounding view of the world.” —Dr. Ervin Laszlo, author, Science and the Akashic Field“An enlightening exploration.” —Julia Ann Charpentier, ForeWord Reviews

The Purposeful Universe: How Quantum Theory and Mayan Cosmology Explain the Origin and Evolution of Life

by Carl Johan Calleman

Identifying the Mayan World Tree with the central axis of the cosmos, the author shows how evolution is not random • Shows how the evolution of the universe emanates from the cosmic Tree of Life • Explains the origin and evolution of biological life and consciousness and how this is directed Using recent findings within cosmology, coupled with his broad understanding of the Mayan Calendar, biologist Carl Johan Calleman offers a revolutionary and fully developed ­alternative to Darwin’s theory of biological evolution--and the theory of randomness that holds sway over modern science. He shows how the recently discovered central axis of the universe correlates with the Tree of Life of the ancients. This provides an entirely new context for physics in general and especially for the origin and evolution of life and suggests that we look upon ourselves as parts of a hierarchy of systems that are all interrelated and evolve in a synchronized way. Calleman’s research demonstrates that life did not just accidentally “pop up” on our planet, but that Earth was a place specifically tagged for this. He demonstrates how the Mayan Calendar describes different quantum states of the Tree of Life and presents a new explanation for the origin and evolution of consciousness. Calleman uses his scientific background in biology and cosmology to show that the idea of the Purposeful Universe is real. He explains not only how DNA but also entire organisms have emerged in the image of the Tree of Life, a theory that has wide-ranging consequences not only for medicine but also for the origin of sacred geometry and the human soul. With this new theory of biological evolution the divide between science and religion disappears.

Pursuing Power and Light: Technology and Physics from James Watt to Albert Einstein (Johns Hopkins Introductory Studies in the History of Science)

by Bruce J. Hunt

In the nineteenth century, science and technology developed a close and continuing relationship. The most important advancements in physics—the science of energy and the theory of the electromagnetic field—were deeply rooted in the new technologies of the steam engine, the telegraph, and electric power and light. Bruce J. Hunt here explores how the leading technologies of the industrial age helped reshape modern physics.This period marked a watershed in how human beings exerted power over the world around them. Sweeping changes in manufacturing, transportation, and communications transformed the economy, society, and daily life in ways never before imagined. At the same time, physical scientists made great strides in the study of energy, atoms, and electromagnetism. Hunt shows how technology informed science and vice versa, examining the interaction between steam technology and the formulation of the laws of thermodynamics, for example, and that between telegraphy and the rise of electrical science.Hunt’s groundbreaking introduction to the history of physics points to the shift to atomic and quantum physics. It closes with a brief look at Albert Einstein’s work at the Swiss patent office and the part it played in his formulation of relativity theory. Hunt translates his often-demanding material into engaging and accessible language suitable for undergraduate students of the history of science and technology.

Pursuing Sustainability: OR/MS Applications in Sustainable Design, Manufacturing, Logistics, and Resource Management (International Series in Operations Research & Management Science #301)

by Chialin Chen Yihsu Chen Vaidyanathan Jayaraman

This handbook includes three parts, corresponding to the following three domains of OR/MS research related to sustainability: (i) Systems Design, Innovation, and Technology, (ii) Manufacturing, Logistics, and Transportation, and (iii) Sustainable Natural Resource Management. The first part of the handbook (Chapters 2-6) will focus on the creation and development of sustainable products, services, value chains, and organizations from a systems perspective. Key areas to be covered include Green Design & Innovation, Technology and Engineering Management, Sustainable Value Chain Systems, Sustainability Standards and Performance Evaluation, and Circular Economy and New Research Directions in Sustainability. The second part of the handbook (Chapters 7-11) will concentrate on the major operational and logistic issues faced by today’s industries in pursuing sustainability. Key areas to be covered include Remanufacturing, Reverse Logistics, Closed-Loop Supply Chains, Sustainable Transportation, and New Research Directions in Green Supply Chain Management. The third part of the proposed handbook (Chapters 12-16) will center on major sustainability issues in managing engineering infrastructure and natural resources. Key areas to be covered include Renewable Energy, Sustainable Water Resource, Biofuel Infrastructure, Natural Gas, and New Research Direction in Sustainable Resource Management.The handbook aims to bridge the three main OR/MS research domains in sustainability: “Systems Design, Innovation, and Technology,” “Manufacturing, Logistics, and Transportation,” and “Sustainable Natural Resource Management.” Traditionally, these domains are treated separately in the OR/MS literature. By combining the three domains, the handbook will provide a more holistic treatment of MS/OR methodologies to address critical sustainability issues faced by today’s society. Unlike most existing handbooks which only focus on current OR/MS research in sustainability within a domain, this handbook will include a concluding chapter in each of the three parts to discuss and identify potential future research directions in each of the three main domains.

Pursuing the Unity of Science: Ideology and Scientific Practice from the Great War to the Cold War (Science, Technology and Culture, 1700-1945)

by Harmke Kamminga Geert Somsen

From 1918 to the late 1940s, a host of influential scientists and intellectuals in Europe and North America were engaged in a number of far-reaching unity of science projects. In this period of deep social and political divisions, scientists collaborated to unify sciences across disciplinary boundaries and to set up the international scientific community as a model for global political co-operation. They strove to align scientific and social objectives through rational planning and to promote unified science as the driving force of human civilization and progress. This volume explores the unity of science movement, providing a synthetic view of its pursuits and placing it in its historical context as a scientific and political force. Through a coherent set of original case studies looking at the significance of various projects and strategies of unification, the book highlights the great variety of manifestations of this endeavour. These range from unifying nuclear physics to the evolutionary synthesis, and from the democratization of scientific planning to the utopianism of H.G. Wells's world state. At the same time, the collection brings out the substantive links between these different pursuits, especially in the form of interconnected networks of unification and the alignment of objectives among them. Notably, it shows that opposition to fascism, using the instrument of unified science, became the most urgent common goal in the 1930s and 1940s. In addressing these issues, the book makes visible important historical developments, showing how scientists participated in, and actively helped to create, an interwar ideology of unification, and bringing to light the cultural and political significance of this enterprise.

The Pursuit of Harmony: Kepler on Cosmos, Confession, and Community

by Aviva Rothman

A committed Lutheran excommunicated from his own church, a friend to Catholics and Calvinists alike, a layman who called himself a “priest of God,” a Copernican in a world where Ptolemy still reigned, a man who argued at the same time for the superiority of one truth and the need for many truths to coexist—German astronomer Johannes Kepler was, to say the least, a complicated figure. With The Pursuit of Harmony, Aviva Rothman offers a new view of him and his achievements, one that presents them as a story of Kepler’s attempts to bring different, even opposing ideas and circumstances into harmony. Harmony, Rothman shows, was both the intellectual bedrock for and the primary goal of Kepler’s disparate endeavors. But it was also an elusive goal amid the deteriorating conditions of his world, as the political order crumbled and religious war raged. In the face of that devastation, Kepler’s hopes for his theories changed: whereas he had originally looked for a unifying approach to truth, he began instead to emphasize harmony as the peaceful coexistence of different views, one that could be fueled by the fundamentally nonpartisan discipline of mathematics.

The Pursuit of Parenthood: Reproductive Technology from Test-Tube Babies to Uterus Transplants

by Margaret Marsh Wanda Ronner

A wide-ranging history of assisted reproductive technologies and their ethical implications.Finalist of the PROSE Award for Best Book in History of Science, Medicine and Technology by the Association of American PublishersSince the 1978 birth of the first IVF baby, Louise Brown, in England, more than eight million children have been born with the help of assisted reproductive technologies. From the start, they have stirred controversy and raised profound questions: Should there be limits to the lengths to which people can go to make their idea of family a reality? Who should pay for treatment? How can we ensure the ethical use of these technologies? And what can be done to address the racial and economic disparities in access to care that enable some to have children while others go without?In The Pursuit of Parenthood, historian Margaret Marsh and gynecologist Wanda Ronner seek to answer these challenging questions. Bringing their unique expertise in gender history and women's health to the subject, Marsh and Ronner examine the unprecedented means—liberating for some and deeply unsettling for others—by which families can now be created. Beginning with the early efforts to create embryos outside a woman's body and ending with such new developments as mitochondrial replacement techniques and uterus transplants, the authors assess the impact of contemporary reproductive technology in the United States. In this volume, we meet the scientists and physicians who have developed these technologies and the women and men who have used them. Along the way, the book dispels a number of fertility myths, offers policy recommendations that are intended to bring clarity and judgment to this complicated medical history, and reveals why the United States is still known as the "Wild West" of reproductive medicine.

The Pursuit of Perfect Packing

by Denis Weaire Tomaso Aste

Coauthored by one of the creators of the most efficient space packing solution, the Weaire-Phelan structure, The Pursuit of Perfect Packing, Second Edition explores a problem of importance in physics, mathematics, chemistry, biology, and engineering: the packing of structures. Maintaining its mathematical core, this edition continues and rev

The Pursuit of Perfection: The Promise and Perils of Medical Enhancement

by David Rothman Sheila Rothman

What does it mean to live in a time when medical science can not only cure the human body but also reshape it? How should we as individuals and as a society respond to new drugs and genetic technologies? Sheila and David Rothman address these questions with a singular blend of history and analysis, taking us behind the scenes to explain how scientific research, medical practice, drug company policies, and a quest for peak performance combine to exaggerate potential benefits and minimize risks. They present a fascinating and factual story from the rise of estrogen and testosterone use in the 1920s and 1930s to the frenzy around liposuction and growth hormone to the latest research into the genetics of aging. The Rothmans reveal what happens when physicians view patients' unhappiness and dissatisfaction with their bodies--short stature, thunder thighs, aging--as though they were diseases to be treated. The Pursuit of Perfection takes us from the early days of endocrinology (the belief that you are your hormones) to today's frontier of genetic enhancements (the idea that you are your genes). It lays bare the always complicated and sometimes compromised positions of science, medicine, and commerce. This is the book to read before signing on for the latest medical fix.From the Hardcover edition.

The Pursuit of Reality: Narrative History of the Quantum and the Great Minds That Made it

by Selçuk Ş. Bayın

In a highly accessible style, this book presents a narrative history of the quantum theory with the new developments that intrigue all inquisitive minds. Quantum theory is counter-intuitive and sometimes downright weird. Even Nobel Laureate physicists like Richard Feynman admit that they do not understand it. Yet, so far, there is not a shred of experimental data that conflicts with its predictions. Its effect on our lives is bound to increase with the quantum information era ushered in by the great Bohr–Einstein debate. Tantalizing applications of quantum information like teleportation, spy-proof communication, super-fast quantum computers, and more are going to influence our lives and change our beliefs about the nature of physical reality. This book takes the reader on an exhilarating journey through the intellectual history of quantum that is turning out to be more surprising every day.

Purves Biologie

by David Sadava David M. Hillis H. Craig Heller Sally D. Hacker

Neu im Purves: Evolution erheblich erweitertZoologie-Kapitel und -Glossar (neu!) durch Mitarbeit von Mary Berenbaum verbessertWeb-Links "Animated Tutorial" und "Web Activity" verweisen auf kostenfreie seite www.thelifewire.comAnzahl der Boxen "Experiment" sind deutlich erweitert Strukturierung erheblich verbessert durch Schlüsselsätze, Boxen zur "Wiederholung", "Kapitelüberblick" und "Kapitel-Zusammenfassung" sowie Fragen zur Selbstkontrolle70% neue Kapitel-Eröffnungenalle Texte von Biologie-Dozenten kritisch durchgesehen

Push and Pull

by Hollie J. Endres

Young readers can find out more about how different objects can be pushed and pulled, and the scientific forces behind motion.

Push And Pull

by Patricia J. Murphy

This Rookie Read-About Science book introduces kids to pushing and pulling. Colorful photos and simple text encourage children to read on their own as they learn about these forces and how they affect the movement of different objects.

Push or Pull?

by Wiley Blevins

Phonics Readers is a recognized leader in helping you teach phonics and phonemic awareness, within the context of content-area reading. Content area focus: Pushes or Pulls Phonics Skills: long u (u_e, ew), inflectional ending -ed

Push Or Pull?

by Wiley Blevins

Discusses forces such as push or pull in an easy-to-read text that incorporates phonics instruction and rebuses.

Push, Pull, Lift!

by Sophie Petratos Vicki Rushworth David Haggerty

In this book, learn about simple machines and how people use them to push, pull, and lift.

Push-Pull Morning: Dog-Powered Poems About Matter and Energy

by Lisa Westberg Peters

Introduce children to physics through play, poetry, and a puppy in this joyous celebration of how physics matters in our everyday lives.This remarkable picture book explores scientific concepts (gravity, magnetism, electricity, friction, etc.) through the story of the relationship between a child and a puppy. Acclaimed author Lisa Westberg Peters&’s poems convey concepts in a way that children will remember—often with humor. Who could forget the various phases when they&’re presented in the form of a dog—solid when eating dinner, liquid when pouring herself into her basket, and gas when leaping erratically after a fly? Serge Bloch&’s whimsical illustrations extend the humor—and the love—in this tale of a child, a dog, and the energy that abounds in their world.Extensive notes at the end of the book define and explain the physics subjects included in the poems.

Pushing and Pulling

by Ray Moller Peter D. Riley

Pushing and Pulling introduces young readers to the fascinating world of cause and effect, as everyday objects like brushes, swings, and trains are pushed and pulled.

Pushing the Limits: New Adventures in Engineering

by Henry Petroski

Here are two dozen tales in the grand adventure of engineering from the Henry Petroski, who has been called America's poet laureate of technology. Pushing the Limits celebrates some of the largest things we have created-bridges, dams, buildings--and provides a startling new vision of engineering's past, its present, and its future. Along the way it highlights our greatest successes, like London's Tower Bridge; our most ambitious projects, like China's Three Gorges Dam; our most embarrassing moments, like the wobbly Millennium Bridge in London; and our greatest failures, like the collapse of the twin towers on September 11. Throughout, Petroski provides fascinating and provocative insights into the world of technology with his trademark erudition and enthusiasm for the subject.

Put On Your Owl Eyes: Open Your Senses & Discover Nature's Secrets; Mapping, Tracking & Journaling Activities

by Devin Franklin

Children will see the natural world around them with brand new eyes, as they learn to follow its signs, hear its language, and understand its secrets. With this unique and compelling book written by expert environmental educator Devin Franklin, kids aged 8 to 13 will build their own relationship with nature through finding a “Sit Spot” — an outdoor space in the backyard, in a field or in the woods, in a vacant lot or a city park — where they can stop, observe, and become familiar with the flora and fauna that live there. From the Six Arts of Tracking (Who, What, Where, When, Why, and How) and making a habitat map to walking in smooth silence like a fox and learning the basics of bird language, exploration exercises lead young readers on a fascinating journey of discovery as they watch, listen, map, interpret, and write about the sounds, sights, scents, and patterns they encounter. With journaling prompts, map-making activities, and observational tracking practice throughout, Put On Your Owl Eyes is an interactive and thought-provoking guidebook. This publication conforms to the EPUB Accessibility specification at WCAG 2.0 Level AA.

Putting Inequality in Context: Class, Public Opinion, and Representation in the United States

by Christopher Ellis

Rising income inequality is highlighted as one of the largest challenges facing the United States, affecting civic participation and political representation. Although the wealthy often can and do exert more political influence, this is not always the case. To fix political inequality, it is important to understand exactly how class divisions manifest themselves in political outcomes, and what factors serve to enhance, or depress, inequalities in political voice. Christopher Ellis argues citizens’—and legislators’—views of class politics are driven by lived experience in particular communities. While some experience is formally political, on an informal basis citizens learn a great deal about their position in the broader socioeconomic spectrum and the social norms governing how class intersects with day-to-day life. These factors are important for policymakers, since most legislators do not represent “the public” at large, but specific constituencies. Focusing on U.S. congressional districts as the contextual unit of interest, Ellis argues individuals’ political behavior cannot be separated from their environment, and shows how income’s role in political processes is affected by the contexts in which citizens and legislators interact. Political inequality exists in the aggregate, but it does not exist everywhere. It is, rather, a function of specific arrangements that depress the political influence of the poor. Identifying and understanding these factors is a crucial step in thinking about what reforms might be especially helpful in enhancing equality of political voice.

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