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A Practical Guide to Assay Development and High-Throughput Screening in Drug Discovery
by Taosheng ChenThe development of suitable assays, the integration of appropriate technology, and the effective management of the essential infrastructure are all critical to the success of any high-throughput screening (HTS) endeavor. However, few scientists have the multidisciplinary experience needed to control all aspects of an HTS drug discovery project. A P
A Practical Guide to Atmospheric Simulation Chambers
by Jean-François Doussin Hendrik Fuchs Astrid Kiendler-Scharr Paul Seakins John WengerThis open access title presents atmospheric simulation chambers as effective tools for atmospheric chemistry research. State-of-the-art simulation chambers provide unprecedented opportunities for atmospheric scientists to perform experiments that address the most important questions in air quality and climate research. The book covers technical details about chamber preparation and practical guidelines on their usage, while also delivering relevant historical and contextual information. It not only serves as a key publication for knowledge transfer within the simulation chamber research community, but it also provides the global atmospheric science community with a unique resource that outlines best practice for the operation of simulation chambers. The authors summarize the latest advances in chamber interoperability and standard protocols in order to provide the research community and the next generations of scientists with a unique technical reference guide for the use of simulation chambers. The volume will be of great interest to researchers and graduates working in the fields of Atmospheric and Environmental Sciences.
A Practical Guide to Biomedical Research
by Peter Agger Robert S. Stephenson J. Michael HasenkamThis book advises and supports novice researchers in taking their first steps into the world of scientific research. Through practical tips and tricks presented in a clear, concise and step-wise manner, the book describes the entire research process from idea to publication. It also gives the reader insight into the vast opportunities a research career can provide. The books target demographic is aspiring researchers within the biomedical professions, be it medical students, young doctors, nurses, engineers, physiotherapists etc. The book will help aspirational inexperienced researchers turn their intentions into actions, providing crucial guidance for successful entry into the field of biomedical research.
A Practical Guide to Borehole Geophysics in Environmental Investigations
by W. Scott KeysBorehole geophysics is frequently applied in hydrogeological environmental investigations where, for example, sites must be evaluated to determine the distribution of contaminants. It is a cost-effective method for obtaining information during several phases of such investigations. Written by one of world's leading experts in the field, A Practical Guide to Borehole Geophysics in Environmental Investigations explains the basic principles of the many tools and techniques used in borehole logging projects. Applications are presented in terms of broad project objectives, providing a hands-on guide to geophysical logging programs, including specific examples of how to obtain and interpret data that meet particular hydrogeologic objectives.
Practical Guide To Chemometrics
by Paul GemperlineThe limited coverage of data analysis and statistics offered in most undergraduate and graduate analytical chemistry courses is usually focused on practical aspects of univariate methods. Drawing in real-world examples, Practical Guide to Chemometrics, Second Edition offers an accessible introduction to application-oriented multivariate meth
Practical Guide to ChIP-seq Data Analysis (Focus Computational Biology Series)
by Borbala Mifsud Kathi Zarnack Anaïs F BardetChromatin immunoprecipitation sequencing (ChIP-seq), which maps the genome-wide localization patterns of transcription factors and epigenetic marks, is among the most widely used methods in molecular biology. Practical Guide to ChIP-seq Data Analysis will guide readers through the steps of ChIP-seq analysis: from quality control, through peak calling, to downstream analyses. It will help experimental biologists to design their ChIP-seq experiments with the analysis in mind, and to perform the basic analysis steps themselves. It also aims to support bioinformaticians to understand how the data is generated, what the sources of biases are, and which methods are appropriate for different analyses.
Practical Guide to Clinical Data Management
by Susanne ProkschaThe management of clinical data, from its collection during a trial to its extraction for analysis, has become critical in preparing a regulatory submission and obtaining approval to market a treatment. Groundbreaking on its initial publication nearly 14 years ago, and evolving with the field in each iteration since then, this latest volume includes revisions to all chapters to reflect the recent updates to ICH E6, good clinical practices, electronic data capture, and interactive response technologies. Keeping the coverage practical, the author focuses on the most critical information that impacts clinical trial conduct, providing a full end-to-end overview for clinical data managers.Features: Provides an introduction and background information for the spectrum of clinical data management tasks. Outstanding text in the industry and has been used by the Society for Clinical Data Management in creating its certification exam. Explains the high-level flow of a clinical trial from creation of the protocol through study lock. Reflects electronic data capture and interactive response technologies. Discusses using the concept of three phases in the clinical data management of a study: study startup, study conduct, and study closeout, to write procedures and train staff.
Practical Guide to Diagnostic Parasitology (ASM Books #141)
by Lynne Shore GarciaIn the 21st century the field of diagnostic medical parasitology continues to see dramatic changes, including newly recognized pathogens and the changing endemicity and classification of familiar organisms; neglected tropical diseases and the impact of global climate change; and new methodologies and risk management issues. This classic clinical laboratory parasitology reference, now in its third edition, has been extensively revised and updated in a new full-color format. Still organized to provide maximum help to the user, particularly from the bench perspective, every section has been expanded with new images and discussion. Specimen collection, preservation, and testing options are thoroughly discussed, from the routine ova and parasite examination to blood films, fecal immunoassays, and the newer molecular test panels. Specific test procedures, laboratory methods and reagents, and algorithms are provided. The ever-helpful “FAQ” section of commonly asked questions now offers expanded information on stool specimen fixatives and testing, thorough coverage of new techniques, and advice on reporting and commenting on results. The heart of the Guide, covering identification of individual pathogens, has been expanded with more discussion and comparison of organisms and dozens of new color images. An entirely new section has been added that uses extensive figures and new tables to illustrate common problems with differentiating organisms from one another and from possible microscopic artifacts. The final section has been reorganized to include identification keys and dozens of tables summarizing organism characteristics to assist the bench microbiologist with routine diagnostic testing methods.
Practical Guide to Digital Manufacturing: First-Time-Right for Design of Products, Machines, Processes and System Integration
by Zhuming BiThis book covers the subject of digital manufacturing. It provides a practical guide for readers on using computer aided design (CAD), computer aided engineering (CAE) and computer aided manufacturing (CAM) and other computer assistive tools for the design of products, machines, processes and system integrations through the case studies of engineering projects. The book introduces a thorough theoretical foundation and discussion of the historical development, and enabling technologies of digital manufacturing. It also covers a broad range of computer aided tools for a variety of applications including: geometric modelling;assembly modelling;motion simulation;finite element analysis;manufacturing process simulation;machining programming;product data management; and,product lifecycle management. Practical Guide to Digital Manufacturing uses many real-world case studies to illustrate the discussed applications, making it easily readable for undergraduate and graduate students, as well as engineers with the needs of computer-aided design and manufacturing knowledge and skills.
A Practical Guide to Drug Development in Academia: The SPARK Approach
by Daria Mochly-Rosen Kevin Grimes"A lot of hard-won knowledge is laid out here in a brief but informative way. Every topic is well referenced, with citations from both the primary literature and relevant resources from the internet." Review of first edition from Nature Chemical BiologyWritten by the founders of the SPARK program at Stanford University, this book is a practical guide designed for professors, students and clinicians at academic research institutions who are interested in learning more about the drug development process and how to start transforming their basic research discoveries into novel drugs. Often many potentially transformative basic science discoveries are not pursued because they are deemed ‘too early’ to attract industry interest. This comprehensive book lays out simple, relatively cost-effective things that academic researchers can do to advance their findings to the point that they can be tested in the clinic or attract more industry interest.Each chapter broadly discusses an important topic in drug development, from discovery, optimization and preclinical studies through clinical trial design, regulatory issues and marketing assessments. After the practical overview provided here, the reader is encouraged to consult more detailed texts on specific topics of interest.The SPARK model has been adopted in over 60 institutions on six continents, and the program has been honored with multiple awards including the 2020 Xconomy Award for Ecosystem Development, the 2020 Cures Within Reach Award for Patient Impact Research, and the 2022 California Life Sciences Pantheon Award for Academia, Non-Profits, & Research.The new edition updates every chapter with the latest developments since the 2014 publication of the first edition.
A Practical Guide to Environmental Biotechnology (Learning Materials in Biosciences)
by Jayanta Kumar Patra Gitishree Das Swagat Kumar Das Hrudayanath ThatoiThis textbook provides practical guidelines on conducting experiments across the entire spectrum of environmental biotechnology. It opens with general information on laboratory safety, rules and regulations, as well as a description of various equipment commonly used in environmental laboratories. It then discusses in detail the major experiments in basic and advanced environmental studies, including the analysis of water and soil samples; the isolation, culture, and biochemical characterization of microbes; and plant tissue culture techniques and nutrient analyses. Each chapter features detailed method sections and easy-to-follow protocols, and offers guidance on calculations and formulas, as well as illustrative flow charts to assist with troubleshooting for each experiment. Given its scope, the book is an invaluable aid for laboratory researchers studying environmental biotechnology, and a rich source of information and advice for advanced undergraduates and graduates in the fields of environmental science and biotechnology.
Practical Guide to Finite Elements: A Solid Mechanics Approach
by Steven LepiAssuming only basic knowledge of mathematics and engineering mechanics, this lucid reference introduces the fundamentals of finite element theory using easy-to-understand terms and simple problems-systematically grounding the practitioner in the basic principles then suggesting applications to more general cases.Furnishes a wealth of practical insights drawn from the extensive experience of a specialist in the field!Generously illustrated with over 200 detailed drawings to clarify discussions and containing key literature citations for more in-depth study of particular topics, this clearly written resource is an exceptional guide for mechanical, civil, aeronautic, automotive, electrical and electronics, and design engineers; engineering managers; and upper-level undergraduate, graduate, and continuing-education students in these disciplines.
Practical Guide to Hereditary Breast and Ovarian Cancer: Annual Meeting of the Japanese Organization of Hereditary Breast and Ovarian Cancer 2021
by Daisuke Aoki Seigo Nakamura Yoshio MikiThis book shares cutting-edge evidence on Hereditary Breast and Ovarian Cancer (HBOC) treatment, delivering facts on breast cancer, gynecologic oncology, and basic research to contribute to clinicians' practices. Each chapter presents the latest clinical techniques, basic experimental results, and the best-chosen research findings. The book is based on the works presented at the Japanese Organization of Hereditary Brest and Ovarian Cancer (JOHBOC) and a special chapter delivers a study based on the extensive data from the Japanese HBOC patients registered in the society's database, presenting novel evidence for further advancement in the field. The practice for HBOC has been rapidly increasing due to the clinical development of poly(ADP-ribose) polymerase inhibitors and the spread of companion diagnostics. In addition, the insurance coverage of a part of HBOC treatment raised social awareness in Japan, and the book illustrates not only clinical efforts but also issues related to the social system and the efforts of the association of related organizations. Hereditary Breast and Ovarian Cancer – Annual meeting of JOHBOC will be of interest to breast surgeons, obstetricians and gynecologists, pancreatic cancer surgeons, and urologists engaged in HBOC treatment through the implementation of companion diagnostics for PARP inhibitors administration. Also, physicians occupied in genetic medicine who perform genetic testing and medical staff practicing HBOC will find this book insightful. It is also for HBOC patients and their families, medical administrators in the social system of HBOC practice. Editors and authors hope to contribute to the equalization and widespread of HBOC practice and serve as a foundation for future advances in the disease's treatment and medical practice.
Practical Guide to ICP-MS and Other Atomic Spectroscopy Techniques: A Tutorial for Beginners (Practical Spectroscopy)
by Robert ThomasWritten by one of the very first practitioners of ICP-MS, Practical Guide to ICP-MS and Other Atomic Spectroscopy Techniques: A Tutorial for Beginners presents ICP-MS in a completely novel and refreshing way. By comparing it with other complementary atomic spectroscopy (AS) techniques, it gives the trace element analysis user community a glimpse into why the technique was first developed and how the application landscape has defined its use today, 40 years after it was first commercialized in 1983. What’s new in the 4th edition: Updated chapters on the fundamental principles and applications of ICP-MS New chapters on complementary AS techniques including AA, AF, ICP-OES, MIP-AES, XRF, XRD, LIBS, LALI-TOFMS Strategies for reducing errors and contamination with plasma spectrochemical techniques Comparison of collision and reaction cells including triple/multi quad systems Novel approaches to sample digestion Alternative sample introduction accessories Comprehensive glossary of terms used in AS New vendor contact information The book is not only suited to novices and beginners, but also to more experienced analytical scientists who want to know more about recent ICP-MS developments, and where the technique might be heading in the future. Furthermore, it offers much needed guidance on how best to evaluate commercial AS instrumentation and what might be the best technique, based on your lab’s specific application demands.
Practical Guide to Industrial Boiler Systems
by Ralph VandagriffThis volume covers the fundamentals of boiler systems and gathers hard-to-find facts and observations for designing, constructing and operating industrial power plants in the United States and overseas. It contains formulas and spreadsheets outlining combustion points of natural gas, oil and solid fuel beds. It also includes a boiler operator's tra
A Practical Guide to Industrial Ecology by Input-Output Analysis: Matrix-Based Calculus of Sustainability
by Shinichiro NakamuraThis book addresses the growing need for a standard textbook on input-output analysis (IO) within the context of industrial ecology (IE). IE is a discipline dedicated to providing system-wide, quantitative, and science-based solutions for sustainable development challenges, and its global importance has been rapidly increasing. The primary analytical tools of IE are life-cycle assessment (LCA) and material flow analysis (MFA). IO has been widely utilized for LCA since the late 1990s and is increasingly being applied to MFA as well. This trend is being driven by the greater availability and application of global IO data, which now includes an ever-expanding number of countries and regions. Despite the presence of excellent textbooks on IO and IE individually, there is a lack of resources that integrate these two fields. This book seeks to fill that gap by focusing on the practical application of IO to IE, specifically in the context of LCA and MFA. By combining these methodologies, readers can gain valuable insights into sustainable development issues and contribute to more effective solutions in the field of IE.
Practical Guide to Infrared Microspectroscopy (Practical Spectroscopy)
by Howard J. HumeckiThis work represents a sound introduction to the fundamental principles of infrared microspectroscopy (IMS). It describes how IMS is used to solve specific microanalytical problems in a variety of disciplines, including forensic analysis, art conservation, and geological, pharmaceutical and electronics research. The book discusses when and how to u
A Practical Guide to Instrumental Analysis
by Erno Pungor G. HorvaiA Practical Guide to Instrumental Analysis covers basic methods of instrumental analysis, including electroanalytical techniques, optical techniques, atomic spectroscopy, X-ray diffraction, thermoanalytical techniques, separation techniques, and flow analytical techniques. Each chapter provides a brief theoretical introduction followed by basic and special application experiments. This book is ideal for readers who need a knowledge of special techniques in order to use instrumental methods to conduct their own analytical tasks.
Practical Guide to International Standardization for Electrical Engineers: Impact on Smart Grid and e-Mobility Markets
by Hermann J. KochPractical Guide to International Standardization for Electrical Engineering provides a comprehensive guide to the purpose of standards organizations, their relationship to product development and how to use the standardization process for cost-effective new product launch. It covers major standardization organizations in the field of Electrical Engineering offering a general overview of the varying structures of national standardization organizations, their goals and targets. Key questions for standardization are answered giving the reader guidance on how to use national and international standards in the electrical business. When shall the company start to enter standardization? How to evaluate the standardization in relationship to the market success? What are the interactions of innovations and market access? What is the cost of standardization? What are the gains for our experts in standardization? Key features: Provides guidance on how to use national and international standards in the electrical business. Global active standardization bodies featured include IEEE, IEC and CIGRE as well as regional organizations like CENELEC for Europe, SAC for China, DKE for Germany, and ANSI for USA. Case studies demonstrate how standardization affects the business and how it may block or open markets. Explains the multiple connections and influences between the different standardization organizations on international, regional or national levels and regulatory impact to the standardization processes. Two detailed focused case studies, one on Smart Grid and one on Electro-Mobility, show the influence and the work of international standardization. The case studies explain how innovative technical developments are promoted by standards and what are the roles of standardization organizations are. A valuable reference for electrical engineers, designers, developers, test engineers, sales engineers, marketing engineers and users of electrical equipment as well as authorities and business planners to use and work with standards.
Practical Guide to Large Database Migration
by Preston ZhangIt is a major challenge to migrate very large databases from one system, say for example, to transfer critical data from Oracle to SQL Server. One has to consider several issues such as loss of data being transferred, the security of the data, the cost and effort, technical aspects of the software involved, etc. There a very few books that provide practical tools and the methodology to migrate data from one vendor to another. This book introduces the concepts in database migration with large sample databases. It provides step by step guides and screenshots for database migration tools. Many examples are shown for migrating Oracle, SQL Server and MySQL databases.
Practical Guide to Life Science Databases
by Imad Abugessaisa Takeya KasukawaThis book provides the latest information of life science databases that center in the life science research and drive the development of the field. It introduces the fundamental principles, rationales and methodologies of creating and updating life science databases. The book brings together expertise and renowned researchers in the field of life science databases and brings their experience and tools at the fingertips of the researcher. The book takes bottom-up approach to explain the structure, content and the usability of life science database. Detailed explanation of the content, structure, query and data retrieval are discussed to provide practical use of life science database and to enable the reader to use database and provided tools in practice. The readers will learn the necessary knowledge about the untapped opportunities available in life science databases and how it could be used so as to advance basic research and applied research findings and transforming them to the benefit of human life.Chapter 2 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
A Practical Guide to Lightcurve Photometry and Analysis (The Patrick Moore Practical Astronomy Series)
by Brian D. D. WarnerTools for amateur astronomers who wish to go beyond CCD imaging and step into 'serious' science. The text offers techniques for gathering, analyzing, and publishing data, and describes joint projects in which amateurs and students can take part. Readers learn to recognize and avoid common errors in gathering photometry data, with detailed examples for analysis. Includes reviews of available software, with screen shots and useful tips.
A Practical Guide to Managing Clinical Trials
by JoAnn Pfeiffer Cris WellsA Practical Guide to Managing Clinical Trials is a basic, comprehensive guide to conducting clinical trials. Designed for individuals working in research site operations, this user-friendly reference guides the reader through each step of the clinical trial process from site selection, to site set-up, subject recruitment, study visits, and to study close-out. Topics include staff roles/responsibilities/training, budget and contract review and management, subject study visits, data and document management, event reporting, research ethics, audits and inspections, consent processes, IRB, FDA regulations, and good clinical practices. Each chapter concludes with a review of key points and knowledge application. <P><P> Unique to this book is "A View from India," a chapter-by-chapter comparison of clinical trial practices in India versus the U.S. Throughout the book and in Chapter 10, readers will glimpse some of the challenges and opportunities in the emerging and growing market of Indian clinical trials.
A Practical Guide to Metabolomics Applications in Health and Disease: From Samples to Insights into Metabolism (Learning Materials in Biosciences)
by Julijana Ivanisevic Martin GieraThis well-accessible textbook constitutes a practical guide to metabolomics approaches and applications in an integrative manner. Illustrated by numerous real-life examples and case studies the book teaches how to set up and carry out metabolomics experiments, from sample collection to storage techniques, and guides the reader through the potentials and challenges of metabolite analysis. In addition, this textbook shows how to obtain insights into molecular mechanisms deployed in different physiological contexts (e.g., exercise, healthy ageing) as well as in different (metabolic) diseases, be it Diabetes, Cancer, Alzheimer´s Disease, Asthma or others. The book brings together knowledge from biochemical, biological, and medical aspects, and further equips the reader with know-how from sample collection and handling to data processing, analysis and interpretation. This textbook is a must-have for advanced undergraduates and graduate students interested in applied biochemistry and metabolomics, as well as for instructors who teach courses in biomedicine, physiology or biochemistry.
A Practical Guide to Microstructural Analysis of Cementitious Materials
by Karen Scrivener Ruben Snellings Barbara LothenbachA Practical Guide from Top-Level Industry ScientistsAs advanced teaching and training in the development of cementitious materials increase, the need has emerged for an up-to-date practical guide to the field suitable for graduate students and junior and general practitioners.Get the Best Use of Different Techniques and Interpretations of the ResultsThis edited volume provides the cement science community with a state-of-the-art overview of analytical techniques used in cement chemistry to study the hydration and microstructure of cements. Each chapter focuses on a specific technique, not only describing the basic principles behind the technique, but also providing essential, practical details on its application to the study of cement hydration. Each chapter sets out present best practice, and draws attention to the limitations and potential experimental pitfalls of the technique. Databases that supply examples and that support the analysis and interpretation of the experimental results strengthen a very valuable ready reference.Utilizing the day-to-day experience of practical experts in the field, this book: Covers sample preparation issues Discusses commonly used techniques for identifying and quantifying the phases making up cementitious materials (X-ray diffraction and thermogravimetric analysis) Presents good practice oncalorimetry and chemical shrinkage methods for studying cement hydration kinetics Examines two different applications of nuclear magnetic resonance (solid state NMR and proton relaxometry) Takes a look at electron microscopy, the preeminent microstructural characterization technique for cementitious materials Explains how to use and interpret mercury intrusion porosimetry Details techniques for powder characterization of cementitious materials Outlines the practical application of phase diagrams for hydrated cements Avoid common pitfalls by using A Practical Guide to Microstructural Analysis of Cementitious Materials. A one-of-a-kind reference providing the do’s and don’ts of cement chemistry, the book presents the latest research and development of characterisation techniques for cementitious materials, and serves as an invaluable resource for practicing professionals specializing in cement and concrete materials and other areas of cement and concrete technology.