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Principles of Biomedical Sciences and Industry: Translating Ideas into Treatments
by Alexander SchuhmacherPrinciples of Biomedical Sciences and Industry Improve your product development skills to bring new ideas to biomedicine The development of innovative healthcare products, such as biodegradable implants, biopharmaceuticals, or companion diagnostics, requires a multi-disciplinary approach that incorporates scientific evidence with novel and innovative ideas to create new and improved products and treatments. Indeed, product development and the integration of science with commercial aspects have become key challenges for scientists working in the pharmaceutical, biotech, and medtech industries. Using a multi-pronged approach to development, Principles of Biomedical Sciences and Industry combines ideas and methodologies from four of the central areas of focus in the biomedical arena: pharmaceuticals, diagnostics, biomaterials, and medical devices. In doing so, the book covers the entire product lifecycle, from translating a scientific idea into a prototype to product development, launch, and management. Principles of Biomedical Sciences and Industry readers will also find: Several case studies from the most important product categories (pharmaceuticals, diagnostics, medical devices, combination products) Chapters dealing with toxicology and safety risks in development, as well as regulatory approval Key business aspects including how to secure funding, managing intellectual property, and price regulation in the market An ideal resource for teachers and students that conveys the information in an easily-digestible format Ideal for advanced students and young professionals pursuing a career in the biomedical and healthcare industries, Principles of Biomedical Sciences and Industry is an essential reference for those in pharmaceutical industry, biotechnologists, medicinal chemists, bio-engineers, pharma engineers, and management consultants.
Principles of Biopsychology (Principles of Psychology)
by Simon Green Michael Eysenck Nicky HayesThis book is intended to provide an introduction to the basic structure and function of the brain and nervous system, emphasizing relationships with behaviour. The first chapter introduces the field, covering aims, objectives and ethical issues. In chapter 2 the neuron is described, and electrical and chemical conduction presented in detail; this chapter also introduces neurotransmitter pathways and drug effects on normal and abnormal behaviour.; After a general survey of the behavioural organization of the nervous system in chapter 3, three chapters describe how language, learning and memory are related to brain mechanisms, with a particular emphasis on clinical data from human patients, and functional assymetries between the hemispheres. The following chapter outlines the Involvement Of Arousal Systems In Stress, Anxiety And Emotion, And Also covers stress reduction techniques. The arousal theme is maintained in chapter 8 in which sleep is discussed in the context of biological rhythms in psychological and physiological processes.; Chapter 9 covers The Biological Bases Of Motivational States Such As Hunger And Thirst, and discusses the concept of homeostasis. Non-homeostatic drives such as electrical self-stimulation of the brain are also considered. Finally, chapter 10 reviews sensory processes in general, and then concentrates on pain perception and the brain mechanisms underlying visual sensation and perception.; It is intended that the material in this book should satisfy the requirements of both the A-level syllabus for Psychology, whichever Board is taken, and first year introductory undergraduate courses in psychobiology.
Principles of Bloodstain Pattern Analysis: Theory and Practice (Practical Aspects Of Criminal And Forensic Investigation Ser.)
by Stuart H. James Paul E. Kish T. Paulette SuttonAs witnessed in landmark criminal cases, the quality and integrity of bloodstain evidence can be a crucial factor in determining a verdict.
Principles of Bone Regeneration
by Jona J. Sela Itai A. BabPrinciples of Bone Regeneration is a timely publication that addresses the modern aspects of bone healing and repair. This exciting new volume details the convergence of the different experimental and clinical approaches designed for the study and treatment of bone healing in its diverse forms and under varying conditions. Bone healing is affected by a multitude of genetic, environmental, mechanical, cellular and endocrine variables which eventually lead to changes in gene expression that enhance the guided action of osteoblasts (and chondroblasts) to lay down bone that restores, or even improves, the skeletal load bearing capacity. Recent breakthroughs in understanding the regulatory aspects of bone formation and resorption, in both research and clinical arenas offer new modalities to induce, enhances and guide repair processes in bone for the benefit of millions of patients with conditions such as nonunion fractures, critical size defects, orthodontic tooth movement, periodontal bone loss, intraosseous implants and deformed bones.
Principles of Brownian and Molecular Motors (Springer Series in Biophysics #21)
by José Antonio FornésMolecular motors convert chemical energy (typically from ATP hydrolysis) to directed motion and mechanical work. Biomolecular motors are proteins able of converting chemical energy into mechanical motion and force. Because of their dimension, the many small parts that make up molecular motors must operate at energies only a few times greater than those of the thermal baths. The description of molecular motors must be stochastic in nature. Their actions are often described in terms of Brownian Ratchets mechanisms. In order to describe the principles used in their movement, we need to use the tools that theoretical physics give us. In this book we centralize on the some physical mechanisms of molecular motors.
Principles of Cancer Genetics
by Fred BunzThis popular textbook, now in its third edition, provides a theoretical framework for understanding why cancers arise, how they develop and how they can be treated.Particular attention is devoted to the origins of cancer and the application of evolutionary theory to explain how mutant cell populations tend to expand and spread. Focused on the genes and signaling pathways involved in the most common tumors, Principles of Cancer Genetics is a highly readable account that will be of interest to anyone who would like to attain a basic understanding of cancer biology. Students who have completed introductory coursework in genetics, biology and biochemistry, medical students and medical house staff will find this book to be a useful starting point toward mastery of this complex but fascinating topic. This updated edition delves into the critical interactions between growing tumors and the immune system, and introduces the concepts of T cell activation, immunoediting and immune evasion. Novel strategies for cancer diagnosis and prognosis, including new roles for next-generation sequencing and liquid biopsies, as well as established and emerging therapeutic modalities are now described in detail.For laypersons, students and researchers in other fields with a general interest in cancer, this book provides an accessible overview, enriched with many easy-to-understand illustrations. For advanced students considering future study in the field of oncology and cancer research, this concise book is a useful guide to the basic principles that underlie our understanding of cancer.
Principles of Cancer Treatment and Anticancer Drug Development
by Wolfgang LinkThis book explains how current medicines against cancer work and how we find new ones. It provides an easy-to-understand overview of current options to treat patients with cancer, which includes Surgery, Radiation therapy, Chemotherapy, Targeted therapy and Immunotherapy. The efficiency of all these treatments is limited by the capacity of cancer cells to escape therapy. This book explains the mechanisms of anti-cancer drug resistance and strategies to overcome it. The discovery and development process of a new drug is detailed beginning with the identification and validation of a therapeutic target, the identification of an inhibitor of the target and its subsequent preclinical and clinical development until its approval by regulatory authorities. Particular emphasis has been given to specific aspects of the development process including lead generation and optimization, pharmacokinetics, ADME analysis, pharmacodynamics, toxicity and efficacy assessment, investigational new drug (IND) and new drug application (NDA) and the design of clinical trial and their phases. The book covers many aspects of modern personalized oncology and discusses economic aspects of our current system of developing new medicines and its impact on our societies and on future drug research. The author of this book, Dr. Link counts with more than 20 years of experience in biomedical research reflected in numerous publications, patents and key note and plenary presentations at international conferences. Interested readers, students and teachers should read this book as it provides a unique way to learn/teach about basic concepts in oncology and anti-cancer drug research.
Principles of Cardiac Toxicology
by Steven I. BaskinWhat chemicals are poisonous to the heart and why are they toxic?Find out by reading Principles of Cardiac Toxicology. Certain chemicals can produce toxicity by interacting with elements of the cardiovascular system. This book presents the anatomical, physiological, biochemical, and pathological basis for this interaction and describes the
Principles of Cell Adhesion (CRC Press Revivals)
by Peter D. Richardson Manfred SteinerIntended for cell biologists, biophysicists, biochemists, molecular biologists, physiologists, researchers in hemostatsis and thrombosis and pathologists, this book provides an insight into cell adhesion from three interdisciplinary perspectives: fundamental facts of adhesion; molecular biochemistry of adhesion and physiological aspects. It summarizes the basic aspects of surfaces in general and describes the theoretical and experimental tools necessary to investigate cell adhesion, including the basic biochemistry and molecular biology of adhesion. The book offers concise treatment of individual topics, features current material, and provides key references as a guide to further study.
Principles of Cement and Concrete Composites (Structural Integrity #18)
by Natt MakulThis book presents an introduction, a discussion of the concept of the design and the concrete’s development, and the properties and testing of the concrete in fresh and hardened stages. After an introduction to the principles of cement and concrete composites, the reader will find information on the principles of quantum-scaled cement, low-carbon cement, fiber-reinforced concrete, reactive powder concrete, and tailor-made recycled aggregate concrete.
Principles of Chemical Engineering Practice
by George DelanceyEnables chemical engineering students to bridge theory and practiceIntegrating scientific principles with practical engineering experience, this text enables readers to master the fundamentals of chemical processing and apply their knowledge of such topics as material and energy balances, transport phenomena, reactor design, and separations across a broad range of chemical industries. The author skillfully guides readers step by step through the execution of both chemical process analysis and equipment design.Principles of Chemical Engineering Practice is divided into two sections: the Macroscopic View and the Microscopic View. The Macroscopic View examines equipment design and behavior from the vantage point of inlet and outlet conditions. The Microscopic View is focused on the equipment interior resulting from conditions prevailing at the equipment boundaries. As readers progress through the text, they'll learn to master such chemical engineering operations and equipment as:Separators to divide a mixture into parts with desirable concentrationsReactors to produce chemicals with needed propertiesPressure changers to create favorable equilibrium and rate conditionsTemperature changers and heat exchangers to regulate and change the temperature of process streamsThroughout the book, the author sets forth examples that refer to a detailed simulation of a process for the manufacture of acrylic acid that provides a unifying thread for equipment sizing in context. The manufacture of hexyl glucoside provides a thread for process design and synthesis.Presenting basic thermodynamics, Principles of Chemical Engineering Practice enables students in chemical engineering and related disciplines to master and apply the fundamentals and to proceed to more advanced studies in chemical engineering.
Principles of Chemical Engineering Processes: Material and Energy Balances, Second Edition
by Nayef Ghasem Redhouane HendaPrinciples of Chemical Engineering Processes: Material and Energy Balances introduces the basic principles and calculation techniques used in the field of chemical engineering, providing a solid understanding of the fundamentals of the application of material and energy balances. Packed with illustrative examples and case studies, this book:Discuss
Principles of Chemical Engineering Processes: Material and Energy Balances
by null Nayef Ghasem null Redhouane HendaPrinciples of Chemical Engineering Processes: Material and Energy Balances continues to serve an essential text, guiding students on the basic principles and calculation techniques used in the field of chemical engineering and providing a solid understanding of the fundamentals of the application of material and energy balances. This third edition has been updated to reflect advances in the field and feedback from professors and students. Packed with illustrative examples and case studies, this book:• Features learning objectives and homework problems in every chapter, new material on software modeling, and additional and enhanced solved examples and problems.• Discusses problems in material and energy balances related to chemical reactors and explains the concepts of dimensions, units, psychrometry, steam properties, and conservation of mass and energy.• Demonstrates how Python, MATLAB®, and Simulink® can be used to solve complicated problems of material and energy balances, and now features an introduction to the basics of building Simulink models.• Demonstrates how Python and its libraries, such as NumPy and SciPy, can be used to solve complex problems in material and energy balances, and introduces the basics of building models using Python frameworks similar to Simulink.• Shows how to solve steady-state and transient mass and energy balance problems involving multiple-unit processes and recycle, bypass, and purge streams.• Develops quantitative problem-solving skills, specifically the ability to think quantitatively (including numbers and units), the ability to translate words into diagrams and mathematical expressions, the ability to use common sense to interpret vague and ambiguous language in problem statements, and the ability to make judicious use of approximations and reasonable assumptions to simplify problems.• Offers educational software and sample tutorials and quizzes for download.Aimed at both chemical engineering students and professionals, this book helps readers understand how to calculate, manage, and apply the key ideas of material and energy use in chemical processes through real-world examples. Lecture slides and a solutions manual are available with qualifying course adoption.
Principles of Chemistry: A Molecular Approach (MasteringChemistry)
by Nivaldo J. TroPrinciples of Chemistry: A Molecular Approach introduces you to core chemistry concepts without sacrificing rigor. Drawing upon his classroom experience as an award-winning educator, author Nivaldo Tro presents chemistry visually through macroscopic, molecular and symbolic multi-level images. This visual approach helps you see the connections between chemistry, your future career and the world around you. Throughout this student-friendly text, active learning tools will engage you in becoming an expert problem solver and critical thinker. The 4th Edition pairs pedagogical innovation with insights from learning design and educational research to create an active, integrated and easy-to-use framework. This version of Principles of Chemistry: A Molecular Approach features the same content as the traditional bound text in a convenient, 3-hole-punched, loose-leaf format.
Principles of Cognitive Neuroscience, Second Edition
by Dale Purves Roberto Cabeza Scott A. Huettel Kevin S. Labar Michael L. Piatt Marty G. WoldorffWritten by seven leading authors, Principles of Cognitive Neuroscience covers the growing subject of cognitive neuroscience. Now in its second edition, the text has been streamlined for ease of reference. Fully updated and containing more effective pedagogical features, it comes with an upgraded version of Sylvius 4 Online.
Principles of Colloid and Surface Chemistry, Revised and Expanded
by Paul C. Hiemenz Raj RajagopalanThis work aims to familiarize students with the fundamentals of colloid and surface science, from various types of colloids and colloidal phenomena, and classical and modern characterization/measurement techniques to applications of colloids and surface science in engineering, technology, chemistry, physics and biological and medical sciences. The Journal of Textile Studies proclaims "High praise from peers . . .contains valuable information on many topics of interest to food rheologists and polymer scientists …[The book] should be in the libraries of academic and industrial food research organizations" and Chromatographia describes the book as "…an excellent textbook, excellently organised, clearly written and well laid out."
Principles of Combustion
by Allan T. Kirkpatrick Kenneth K. KuoThe new edition of a classic textbook on combustion principles and processes, covering the latest developments in fuels and applications in a student-friendly format Principles of Combustion provides clear and authoritative coverage of chemically reacting flow systems. Detailed and accessible chapters cover key combustion topics such as chemical kinetics, reaction mechanisms, laminar flames, droplet evaporation and burning, and turbulent reacting flows. Numerous figures, end-of-chapter problems, extensive reference materials, and examples of specific combustion applications are integrated throughout the text. Newly revised and expanded, Principles of Combustion makes it easier for students to absorb and master each concept covered by presenting content through smaller, bite-sized chapters. Two entirely new chapters on turbulent reacting flows and solid fuel combustion are accompanied by additional coverage of low carbon fuels such as hydrogen, natural gas, and renewable fuels. This new edition contains a wealth of new homework problems, new application examples, up-to-date references, and access to a new companion website with MATLAB files that students can use to run different combustion cases. Fully updated to meet the needs of today’s students and instructors, Principles of Combustion: Provides problem-solving techniques that draw from thermodynamics, fluid mechanics, and chemistry Addresses contemporary topics such as zero carbon combustion, turbulent combustion, and sustainable fuels Discusses the role of combustion emissions in climate change and the need for reducing reliance on carbon-based fossil fuels Covers a wide range of combustion application areas, including internal combustion engines, industrial heating, and materials processing Containing both introductory and advanced material on various combustion topics, Principles of Combustion, Third Edition, is an essential textbook for upper-level undergraduate and graduate courses on combustion, combustion theory, and combustion processes. It is also a valuable reference for combustion engineers and scientists wanting to better understand a particular combustion problem.
Principles of Composite Material Mechanics (Mechanical Engineering Series)
by Ronald F. GibsonPrinciples of Composite Material Mechanics covers a unique blend of classical and contemporary mechanics of composites technologies. It presents analytical approaches ranging from the elementary mechanics of materials to more advanced elasticity and finite element numerical methods, discusses novel materials such as nanocomposites and hybrid multis
Principles of Computational Modelling in Neuroscience
by David Sterratt Bruce Graham Andrew Gillies David WillshawThe nervous system is made up of a large number of interacting elements. To understand how such a complex system functions requires the construction and analysis of computational models at many different levels. This book provides a step-by-step account of how to model the neuron and neural circuitry to understand the nervous system at all levels, from ion channels to networks. Starting with a simple model of the neuron as an electrical circuit, gradually more details are added to include the effects of neuronal morphology, synapses, ion channels and intracellular signaling. The principle of abstraction is explained through chapters on simplifying models, and how simplified models can be used in networks. This theme is continued in a final chapter on modeling the development of the nervous system. Requiring an elementary background in neuroscience and some high school mathematics, this textbook is an ideal basis for a course on computational neuroscience.
Principles of condensed matter physics
by P. M. Chaikin T. C. LubenskyNow in paperback, this book provides an overview of the physics of condensed matter systems. Assuming a familiarity with the basics of quantum mechanics and statistical mechanics, the book establishes a general framework for describing condensed phases of matter, based on symmetries and conservation laws. It explores the role of spatial dimensionality and microscopic interactions in determining the nature of phase transitions, as well as discussing the structure and properties of materials with different symmetries. Particular attention is given to critical phenomena and renormalization group methods. The properties of liquids, liquid crystals, quasicrystals, crystalline solids, magnetically ordered systems and amorphous solids are investigated in terms of their symmetry, generalised rigidity, hydrodynamics and topological defect structure. In addition to serving as a course text, this book is an essential reference for students and researchers in physics, applied physics, chemistry, materials science and engineering, who are interested in modern condensed matter physics.
Principles of Continuum Mechanics: A Basic Course for Physicists (Nečas Center Series)
by Zdeněk MartinecThis book addresses the basic concepts of continuum mechanics, that is, the classical field theory of deformable bodies. The theory is systematically developed, from the kinematics to the balance equations, the material theory, and the entropy principles. In turn, the linear-elastic solids, the ideal liquid and the Newtonian liquid are presented in detail as concrete applications. The book concludes by covering the theory of small motions in a medium with a finite prestress. In general, the emphasis is on presenting the content in a clear and straightforward way that requires only an elementary grasp of calculus, linear algebra, and Newtonian mechanics. The book is intended for students of physics, mechanics, engineering and the geosciences, as well as applied mathematics, with a year or more of college calculus behind them.
Principles of Continuum Mechanics: Conservation and Balance Laws with Applications
by J. N. ReddyAs most modern technologies are no longer discipline-specific but involve multidisciplinary approaches, undergraduate engineering students should be introduced to the principles of mechanics so that they have a strong background in the basic principles common to all disciplines and are able to work at the interface of science and engineering disciplines. This textbook is designed for a first course on principles of mechanics and provides an introduction to the basic concepts of stress and strain and conservation principles. It prepares engineer-scientists for advanced courses in traditional as well as emerging fields such as biotechnology, nanotechnology, energy systems, and computational mechanics. This simple book presents the subjects of mechanics of materials, fluid mechanics, and heat transfer in a unified form using the conservation principles of mechanics.
Principles of Continuum Mechanics
by J. N. ReddyAs most modern technologies are no longer discipline-specific but involve multidisciplinary approaches, undergraduate engineering students should be introduced to the principles of mechanics so that they have a strong background in the basic principles common to all disciplines and are able to work at the interface of science and engineering disciplines. This textbook is designed for a first course on principles of mechanics and provides an introduction to the basic concepts of stress and strain and conservation principles. It prepares engineer-scientists for advanced courses in traditional as well as emerging fields such as biotechnology, nanotechnology, energy systems, and computational mechanics. This simple book presents the subjects of mechanics of materials, fluid mechanics, and heat transfer in a unified form using the conservation principles of mechanics.
Principles of Controlled Maintenance
by P. Dale JohnsonAn effective, well-managed maintenance program is crucial to the efficient and economical performance of any type of facility. This book presents a complete, step-by-step guide to systematically improving overall maintenance operations, covering maintenance organization, inventory, continuous inspection, planning, scheduling and program management. The presentation is structured in a manner which allows the reader to utilize basic guidelines in implementing a management system which can be customized to the specific requirements and goals of his/her plant or facility, regardless of size or type of operation.
Principles of Cosmology and Gravitation
by Michael V BerryGeneral relativity and quantum mechanics have become the two central pillars of theoretical physics. Moreover, general relativity has important applications in astrophysics and high-energy particle physics. Covering the fundamentals of the subject, Principles of Cosmology and Gravitation describes the universe as revealed by observations and presents a theoretical framework to enable important cosmological formulae to be derived and numerical calculations performed. Avoiding elaborate formal discussions, the book presents a practical approach that focuses on the general theory of relativity. It examines different evolutionary models and the gravitational effects of massive bodies. The book also includes a large number of worked examples and problems, half with solutions.