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Rho GTPases
by Francisco RiveroAlthough initially described as major regulators of cytoskeletal remodeling, Rho GTPases have been implicated in the establishment of polarity, endocytosis, vesicle trafficking, morphogenesis, cytokinesis, transcriptional activation, cell cycle progression, and apoptosis, to mention a few. In addition, Rho GTPases have acquired medical relevance because of their participation in tumorigenesis and metastasis, in cardiovascular conditions, and as targets of infectious agents. The field has broadened even more with the contribution of studies in model organisms (plants, amoebas, fungi, invertebrates), each adding a particular view to the complexity of the family and vastly enriching our perception of these important signaling components. Divided into five convenient sections, Rho GTPase: Methods and Protocols provides an historical overview of the field and an account of the phylogenetics of the Rho family, general biochemical methods, and functional assays that allow monitoring the consequences of manipulating Rho GTPases in a variety of contexts. Additionally, the volume devotes a section to advanced imaging methods and to recently developed high throughput methods, closing with techniques specifically designed for studies in selected non-mammalian model organisms. Written in the successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Rho GTPase: Methods and Protocols provides techniques that are standard for researchers in the field but also includes protocols for those who, being already familiar with some of the techniques, wish to explore additional aspects.
Rho GTPases: Methods And Protocols (Methods in Molecular Biology #827)
by Francisco RiveroThis detailed book expands upon the previous edition with a collection of methods for those performing experimental work on small GTPases of the Rho family. Split into four sections, the volume explores computational modeling and imaging procedures, biochemical methods related to post-translational modifications of Rho GTPases as well as some high throughput methods, functional assays that allow for monitoring the consequences of manipulating Rho GTPases in a variety of cell types and cell biology processes, and techniques specifically designed for studies in selected non-mammalian model organisms (zebrafish, social ameba, plants and algae). Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on trouble shooting and avoiding known pitfalls. Authoritative and up-to-date, Rho GTPases: Methods and Protocols, Second Edition constitutes an invaluable tool for all those with an interest in this remarkable family of signaling proteins.
Rhodiola rosea (Traditional Herbal Medicines for Modern Times)
by Alain Cuerrier Kwesi Ampong-NyarkoThe genus Rhodiola (Family Crassulaceae) is indigenous to Northern Canada, Europe and Asia where its rhizomes and roots have been used for centuries for medicinal purposes. Recent interest in the species Rhodiola rosea (roseroot) in the West arose from the use of the rhizome as an adaptogen for the treatment of stress, but in the last few years, ch
Rhodium Catalysis
by Carmen ClaverIn the last decade there have been numerous advances in the area of rhodium-catalyzed hydroformylation, such as highly selective catalysts of industrial importance, new insights into mechanisms of the reaction, very selective asymmetric catalysts, in situ characterization and application to organic synthesis. The views on hydroformylation which still prevail in the current textbooks have become obsolete in several respects. Therefore, it was felt timely to collect these advances in a book. The book contains a series of chapters discussing several rhodium systems arranged according to ligand type, including asymmetric ligands, a chapter on applications in organic chemistry, a chapter on modern processes and separations, and a chapter on catalyst preparation and laboratory techniques. This book concentrates on highlights, rather than a concise review mentioning all articles in just one line. The book aims at an audience of advanced students, experts in the field, and scientists from related fields. The didactic approach also makes it useful as a guide for an advanced course.
Rhodium Catalysis in Organic Synthesis: Methods and Reactions
by Ken TanakaAn essential reference to the highly effective reactions applied to modern organic synthesis Rhodium complexes are one of the most important transition metals for organic synthesis due to their ability to catalyze a variety of useful transformations. Rhodium Catalysis in Organic Synthesis: Methods and Reactions explores the most recent progress and new developments particularly in the field of catalytic cyclization reactions using rhodium(I) complexes and catalytic carbon-hydrogen bond activation reactions using rhodium(II) and rhodium(III) complexes. Edited by a noted expert in the field with contributions from a panel of leading international scientists, Rhodium Catalysis in Organic Synthesis: Methods and Reactions presents the essential information in one comprehensive volume. Designed to be an accessible resource, the book is arranged by different reaction types. All the chapters provide insight into each transformation and include information on the history, selectivity, scope, mechanism, and application. In addition, the chapters offer a summary and outlook of each transformation. This important resource: Offers a comprehensive review of how rhodium complexes catalyze a variety of highly useful reactions for organic synthesis (e.g. coupling reactions, CH-bond functionalization, hydroformylation, cyclization reactions and others) Includes information on the most recent developments that contain a range of new, efficient, elegant, reliable and useful reactions Presents a volume edited by one of the international leading scientists working in the field today Contains the information that can be applied by researchers in academia and also professionals in pharmaceutical, agrochemical and fine chemical companies Written for academics and synthetic chemists working with organometallics, Rhodium Catalysis in Organic Synthesis: Methods and Reactions contains the most recent information available on the developments and applications in the field of catalytic cyclization reactions using rhodium complexes.
Rhodolith/Maërl Beds: A Global Perspective
by Rafael Riosmena-Rodríguez Wendy Nelson Julio AguirreRhodolith beds are recognized internationally as a unique ecosystem, and they are the focus of this interdisciplinary book. These marine beds occur worldwide, from the tropics to the poles, ranging in depth from intertidal to deep subtidal habitats and they are also represented in extensive fossil deposits. In the light of international interest in rhodoliths and maerl concerning their role in coastal ecosystems and with respect to biodiversity, fisheries, and the production of sediment, this book provides the most comprehensive view possible. As readers will discover, rhodoliths/maerl are fundamental to a range of ecological processes, acting as ecosystem engineers including playing key roles in recruitment and providing nursery habitats. Rhodoliths/maerl have been used commercially in some parts of the world, and they are understood to be vulnerable to coastal modifications and human-induced change, and hence their status may serve as an indicator of ecosystem health. Rhodoliths/maerl contribute to global carbon budgets although the extent remains to be evaluated, as do the potential impacts of changing global climates and ocean acidification.
Rhodophyta - Volume 4: Sporolithales, Corallinales and Hapalidiales (Marine Algal Flora of China #4)
by Guangce WangThis book is the fourth volume of the “Marine Algal Flora of China-Rhodophyta.” The series has seven volumes covering about 20 orders, 45 families, 173 genera, and 560 species including over 150 species firstly described from China, indicating significant importance to the knowledge of North-Western Pacific marine algal flora. The fourth volume covers coralline algae, including Sporolithales, Corallinales, and Hapalidiales.Almost all species involved are illustrated in detail on morphology, inner structure, habitats, and geographical distribution, based upon herbarium specimens collected along the China coast, and a lot of elaborate pictures are attached inside. This flora will gain our understanding of current Chinese marine red algae, but much research is still necessary to reflect the whole picture of the red algal diversity along the China coast.
Rhodophyta Volume 5: Ahnfeltiales, Gigartinales, Sebdeniales, Nemastomatales, Plocamiales, Gracilariales and Rhodymeniales (Marine Algal Flora of China #5)
by Guangce WangThis book is the fifth volume of the “Marine Algal Flora of China-Rhodophyta.” The series has seven volumes covering about 20 orders, 45 families, 173 genera, and 560 species including over 150 species firstly described from China, indicating significant importance to the knowledge of North-Western Pacific marine algal flora. The fifth volume Ahnfeltiales, Gigartinales, Sebdeniales, Nemastomatales, Plocamiales, Gracilariales, and Rhodymeniales. It provides first-hand literatures necessary to phycologists who aimed to study algal taxonomy and diversity, especially in the North Western Pacific region. Almost all species involved are illustrated in detail on morphology, inner structure, habitats, and geographical distribution, based upon herbarium specimens collected along the China coast, and a lot of elaborate pictures are attached inside. This flora will gain our understanding of current Chinese marine red algae, but much research is still necessary to reflect the whole picture of the red algal diversity along the China coast.
Rhodopsin: Methods and Protocols (Methods in Molecular Biology #2501)
by Valentin GordeliyThis volume provides readers with the latest information on the advances made in the field of rhodopsins. The chapters in this book cover topics such as new discoveries and developments; new ways to search for rhodopsins; methods to characterize the function and structure of rhodopsins on a molecular level; nano volume high throughput in meso crystallization, and fourth generation x-ray synchrotron sources. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and thorough, Rhodopsin: Methods and Protocols is a valuable resource for any scientist and researcher interested in learning more about this developing field.
Rhythm in the Sky: Periodic Motions in the Universe (Studies in Rhythm Engineering)
by Gautam Gangopadhyay Anirban KunduThis book provides a brief and pedagogic introduction to a variety of topics, with a common motif that they all occur, in some way or other, in “the sky”, and involve some sort of “rhythm”. Sky is not just the inside of a dome; there are many strata, each with its own beauties and mysteries. As we go up, the atmosphere thins out and ends, and we move into the space, into the realms of planets, asteroids, and comets, and even further, beyond the solar system into the vast Milky Way galaxy. This is where the night sky comes in, with all its twinkling stars, the stars in our own galaxy. We must use telescopes to explore further. In this book, we will start from the ancient astronomers and how they studied the motion of earth through space. Study of planetary orbits, from Kepler and Newton to Einstein, had been fascinating. We will try to take the reader through the wonderful worlds of the cepheid variables and pulsars to the strange oscillations of the neutrinos and the new eye to look at the universe, namely the gravitational waves. The book stops at the discovery of the black hole at the center of our galaxy, but that is just because we must stop somewhere, or the assortment could go on ad infinitum. Some of these topics are highly mathematical in nature, but we will try to avoid the complicated mathematics as much as possible, without compromising with the rigor.
Rhythmic Advantages in Big Data and Machine Learning (Studies in Rhythm Engineering)
by Kanad Ray Anirban BandyopadhyayThe book discusses various aspects of biophysics. It starts from the popular article on neurobiology to quantum biology and ends up with the consciousness of a human being and in the universe. The authors have covered eight nine different aspects of natural intelligence, starting from time crystal found in the chemical biology to the vibrations and the resonance of proteins. They have covered a wide spectrum of hierarchical communication among different biological systems. Most importantly, authors have taken an utmost care that even school-level students fall in love with biophysics; it is simple and more of a textbook and definitely bring the readers to a world of biology and physics like never before. Most authors are experienced academicians, and they have used lucid and simple language to make the content interesting for the readers.
Rhythmic Oscillations in Proteins to Human Cognition (Studies in Rhythm Engineering)
by Kanad Ray Anirban BandyopadhyayThis book explores various aspects of biophysics, from neurobiology to quantum biology and the consciousness of human beings and in the universe. It examines eight different areas of natural intelligence, ranging from time crystals found in chemical biology, to the vibrations and the resonance of proteins, and also discusses hierarchical communication in various biological systems. Written by senior and experts in the field in language that is lucid and easy to understand, it is a valuable reference resource for researchers and practitioners in academia and industry.
Rhythmische Vorteile in Big Data und Machine Learning
by Kanad Ray Anirban BandyopadhyayDas Buch behandelt verschiedene Aspekte der Biophysik, beginnend mit einem populären Artikel über Neurobiologie und erstreckt sich bis zur Quantenbiologie, um letztendlich das Bewusstsein sowohl von Menschen als auch des Universums zu erforschen. Die Autoren haben neun verschiedene Facetten der natürlichen Intelligenz behandelt, angefangen bei der Entdeckung von Zeitkristallen in der chemischen Biologie bis hin zu den Schwingungen und Resonanzen von Proteinen. Sie haben ein breites Spektrum hierarchischer Kommunikation unter verschiedenen biologischen Systemen abgedeckt. Besonderes Augenmerk wurde darauf gelegt, sicherzustellen, dass der Inhalt selbst für Schülerinnen und Schüler zugänglich ist, wodurch die Biophysik wie ein Lehrbuch erscheint, das die Leser in die Bereiche der Biologie und Physik wie nie zuvor entführt. Die Autoren, die größtenteils erfahrene Akademiker sind, haben klare und einfache Sprache verwendet, um sicherzustellen, dass der Inhalt für alle Leser ansprechend und verständlich ist.
Rhythms in Plants
by Sergey Shabala Stefano MancusoThis second edition of a well-received book focuses on rhythmic behaviour in plants, which regulates all developmental and adaptive responses and can thus be regarded as quintessential to life itself. The chapters provide a timely update on recent advances in this field and comprehensively summarize the current state of knowledge concerning the molecular and physiological mechanisms behind circadian and ultradian oscillations in plants, their physiological implications for growth and development and adaptive responses to a dynamic environment. Written by a diverse group of leading researchers, the book will spark the interest of readers from many branches of science: from physicists and chemists wishing to learn about the multi-faceted rhythms in plants, to biologists and ecologists involved in the state-of-the-art modelling of complex rhythmic phenomena.
Rhythms of Insect Evolution: Evidence from the Jurassic and Cretaceous in Northern China
by Dong Ren Chungkun Shih Taiping Gao Yongjie Wang Yunzhi YaoDocuments morphology, taxonomy, phylogeny, evolutionary changes, and interactions of 23 orders of insects from the Middle Jurassic and Early Cretaceous faunas in Northern China This book showcases 23 different orders of insect fossils from the Mid Mesozoic period (165 to 125 Ma) that were discovered in Northeastern China. It covers not only their taxonomy and morphology, but also their potential implications on natural sciences, such as phylogeny, function, interaction, evolution, and ecology. It covers fossil sites; paleogeology; co-existing animals and plants in well-balanced eco-systems; insects in the spotlight; morphological evolution and functional development; and interactions of insects with co-existing plants, vertebrates, and other insects. The book also includes many elegant and beautiful photographs, line drawings, and 3-D reconstructions of fossilized and extant insects. Rhythms of Insect Evolution: Evidence from the Jurassic and Cretaceous in Northern China features chapter coverage of such insects as the: Ephemeroptera; Odonata; Blattaria; Isoptera; Orthoptera; Notoptera; Dermaptera; Chresmodidae; Phasmatodea; Plecoptera; Psocoptera; Homoptera; Heteroptera; Megaloptera; Raphidioptera; Neuroptera; Coleoptera; Hymenoptera Diptera; Mecoptera; Siphonaptera; Trichoptera and Lepidoptera. Combines academic natural science, popular science, and artistic presentation to illustrate rhythms of evolution for fossil insects from the Mid Mesozoic of Northern China Documents morphology, taxonomy, phylogeny, and evolutionary changes of 23 orders of insects from the Middle Jurassic and Early Cretaceous faunas in Northern China Presents interactions of insects with plants, vertebrates, and other insects based on well-preserved fossil evidence Uses photos of extant insects and plants, fossil and amber specimens, line drawings, and 3-D computer-generated reconstruction artworks to give readers clear and enjoyable impressions of the scientific findings Introduces insect-related stories from western and Chinese culture in text or sidebars to give global readers broader exposures Rhythms of Insect Evolution: Evidence from the Jurassic and Cretaceous in Northern China will appeal to entomologists, evolutionists, paleontologists, paleoecologists, and natural scientists.
Rhythms of Life: The Biological Clocks that Control the Daily Lives of Every Living Thing
by Russell G. Foster Leon KreitzmanWhy can’t teenagers get out of bed in the morning? How do bees tell the time? Why do some plants open and close their flowers at the same time each day? Why do so many people suffer the misery of jet lag? In this fascinating book, Russell Foster and Leon Kreitzman explain the significance of the biological clock, showing how it has played an essential role in evolution and why it continues to play a vitally important role in all living organisms. The authors tell us that biological clocks are embedded in our genes and reset at sunrise and sunset each day to link astronomical time with an organism’s internal time. They discuss how scientists are working out the clockwork mechanisms and what governs them, and they describe how organisms measure different intervals of time, how they are adapted to various cycles, and how light coordinates the time within to the external world. They review problems that can be caused by malfunctioning biological clocks--including jet lag, seasonal affective disorder, and depression. And they warn that although new drugs are being promoted to allow us to stay awake for longer periods, a 24/7 lifestyle can have a harmful impact on our health, both as individuals and as a society.
Ribbon of Darkness: Inferencing from the Shadowy Arts and Sciences
by Barbara Maria StaffordOver the course of her career, Barbara Stafford has established herself the preeminent scholar of the intersections of the arts and sciences, articulating new theories and methods for understanding the sublime, the mysterious, the inscrutable. Omnivorous in her research, she has published work that embraces neuroscience and philosophy, biology and culture, pinpointing connections among each discipline’s parallel concerns. Ribbon of Darkness is a monument to the scope of her work and the range of her intellect. At times associative, but always incisive, the essays in this new volume take on a distinctly contemporary purpose: to uncover the ethical force and moral aspects of overlapping scientific and creative inquiries. This shared territory, Stafford argues, offers important insights into—and clarifications of—current dilemmas about personhood, the supposedly menial nature of manual skill, the questionable borderlands of gene editing, the potentially refining value of dualism, and the limits of a materialist worldview. Stafford organizes these essays around three concepts that structure the book: inscrutability, ineffability, and intuitability. All three, she explains, allow us to examine how both the arts and the sciences imaginatively infer meaning from the “veiled behavior of matter,” bringing these historically divided subjects into a shared intellectual inquiry and imbuing them with an ethical urgency. A vanguard work at the intersection of the arts and sciences, this book will be sure to guide readers from either realm into unfamiliar yet undeniably fertile territory.
Ribonuclease P
by Fenyong Liu Sidney AltmanThis volume will discuss all important aspects of RNase P structure and function in eukaryotic, prokaryotic, and viral systems. It will cover a broad range of subjects in RNA research, including: structural analysis by biochemical or biophysical means; mRNA structure, function and biogenesis; ribosome structure and function; translational control; and RNA catalysis. RNA and RNase is an interdisciplinary topic that represents molecular, evolutionary and structural biology, biochemistry, biomedical sciences, chemistry, genetics, and virology as they relate to questions of the structure and function of RNA and of ribonucleoprotein assemblies.
Ribonucleases
by Allen W. NicholsonRibonucleases are a ubiquitous and functionally diverse group of enzymes that have a common ability to cleave RNA. Either through scission of internal phosphodiesters, or removal of nucleotides from RNA 5' or 3' ends, ribonucleases perform essential roles in gene expression and regulation, genome replication and maintenance, host defense, stress response, and viral strategies of infection. Ribonucleases have also served as highly informative models to understand virtually every aspect of biomolecular structure and function. The fifteen chapters in this volume are written by recognized researchers in the field, and provide in-depth analyses of the major ribonuclease families. Particular focus is given to the relation of ribonuclease structure and mechanism to biological function, as well as ribonuclease dysfunction in certain disease states. Other topics include the evolutionary genetics and functional diversification of ribonucleases, engineered ribonucleases as anti-cancer agents, the mechanisms of action of artificial ribonucleases, and ribonucleases as models to understand protein folding and stability. This volume should serve as an essential reference for a broad range of researchers and educators with interests in RNA metabolism, enzymology, and gene regulation.
Riboregulator Design and Analysis (Methods in Molecular Biology #2518)
by James Chappell Melissa K. TakahashiThis collection explores the latest advances in riboregulators, such as RNA-only systems and ribonucleoprotein systems, and provides detailed techniques to study, evolve, and design them. Beginning with a set of chapters focused on the design and application of small RNA (sRNA) regulator systems, the book continues with sections on techniques to create switchable riboregulator systems known as riboswitches, technologies that leverage RNA-guided CRISPR-Cas systems to edit the epigenome, control gene expression, and create diagnostics, as well as computational and experimental techniques to investigate the sequence-structure-function relationship of RNA systems that can both advance fundamental understanding and rational design of riboregulators. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Riboregulator Design and Analysis is an ideal guide for scientists and engineers interested in the design and application of riboregulators and driving further innovation in the field.
Ribosome Display and Related Technologies
by Ronald H. Jackson Julie A. DouthwaiteDisplay technologies have become a very powerful way of generating therapeutic lead molecules and specific reagents for increasing our understanding of biology; however, despite being first described shortly after phage display, the use of ribosome display and related methods have been much less widespread. Since this is in part due to the complexity of the methods, Ribosome Display and Related Technologies: Methods and Protocols seeks to extend their use by collecting expert contributions describing these detailed protocols. The protocols described range from well-established methods that have been used for a decade to generate high affinity antibodies, which are already in the clinic, to methods that are in their early stages of application such as display of peptides incorporating non-canonical amino acids. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Invaluable and easy to use, Ribosome Display and Related Technologies: Methods and Protocols will be of great benefit to those with general molecular biology or protein engineering experience who wish to select peptides or proteins by display, those with phage display experience who would benefit from the application of ribosome display, as well as those with some ribosome display experience who would like to expand the range of applications to which they are applying the technology.
Ribosome Profiling: Methods and Protocols (Methods in Molecular Biology #2252)
by Vyacheslav M. LabunskyyThis book provides a single-source reference on the current state of the ribosome profiling method by describing experimental protocols for the quantitative analysis of translation in a variety of model organisms. In addition, the volume presents a detailed overview of the existing software tools and includes detailed description of methods for statistical analysis, data processing, and visualization of ribosome profiling data. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Ribosome Profiling: Methods and Protocols aims to provide the type of standardized protocols that have previously been unavailable in an effort to bypass the major barriers to wide use of ribosome profiling-based approaches.
Ribosome-inactivating Proteins
by Fiorenzo Stirpe Douglas LappiThis important reference provides up-to-date information on all aspects of ribosome-inactivating proteins (RIPs). Including a list of all known RIPs, their distribution in nature, structure, genetics and chemical and immunological properties, this reference covers mechanisms of action, including the enzymatic activity on various polynucleotide substrates; the interaction with, and entry into cells; the toxicity to animals, including the pathology of poisoning; and the immunomodulatory and allergenic activity. The book further emphasizes the use of immunotoxins and other conjugates in clinical trials for the therapy of cancer and intractable pain.
Riboswitches
by Alexander SerganovThe revolutionary discoveries of RNA interference and bacterial regulatory RNAs led to further breakthroughs such as the identification of riboswitches and related RNA sensors, mRNA regions capable of alternating their conformations in response to the presence of cellular metabolites and other physical or chemical cues. In Riboswitches: Methods and Protocols, expert researchers provide comprehensive and up-to-date coverage of various methods used to study riboswitches and other RNAs involved in gene expression control. Examining biochemical and modern biophysical techniques, the volume focuses on mRNAs responding to small organic molecules but expands the definition of a riboswitch to incorporate classes of RNA that undergo conformational transitions in response to other stimuli in order to control the expression of genes. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Cutting-edge and authoritative, Riboswitches: Methods and Protocols promises to inspire both novices and experts working in a wide range of contemporary biological areas who wish to further develop their RNA methodology.