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RNA Structure Determination
by Douglas H. Turner David H. MathewsThis volume provides protocols and procedures for determining and modeling RNA structure. Chapters guide the reader through protocols for RNA secondary structure prediction, single sequence modeling, Crumple, RNAstructure to model conserved secondary structures with multiple homologs, the prediction of bimolecular secondary structures with RNAstructure, STarMir, protocols for structure mapping, mapping data to constrain or restrain RNA secondary structure prediction with RNAstructure, unassigned NMR resonances, modeling protocols for Rosetta FARFAR, RNAComposer , ModeRNA, and MC-Fold. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and Practical, RNA Structure Determination: Methods and Protocols aims to ensure successful results in the further study of this vital field.
RNA Structure Prediction (Methods in Molecular Biology #2586)
by Risa Karakida Kawaguchi Junichi IwakiriThis book explores recent progress in RNA secondary, tertiary structure prediction, and its application from an expansive point of view. Because of advancements in experimental protocols and devices, the integration of new types of data as well as new analysis techniques is necessary, and this volume discusses additional topics that are closely related to RNA structure prediction, such as the detection of structure-disrupting mutations, high-throughput structure analysis, and 3D structure design. Written for the highly successful Methods in Molecular Biology series, chapters feature the kind of detailed implementation advice that leads to quality research results. Authoritative and practical, RNA Structure Prediction serves as a valuable guide for both experimental and computational RNA researchers.
RNA Tagging: Methods and Protocols (Methods in Molecular Biology #2166)
by Manfred HeinleinThis book provides a compendium of state-of-the-art methods for the labeling, detection, and purification of RNA and RNA-protein complexes and thereby constitutes an important toolbox for researchers interested in understanding the complex roles of RNA molecules in development, signaling, and disease. Beginning with a section on in situ detection of RNA molecules using FISH techniques, the volume continues with parts exploring in vivo imaging of RNA transport and localization, imaging and analysis of RNA uptake and transport between cells, identification and analysis of RNA-binding proteins, guide RNAs in genome editing, as well as other specific analytical techniques. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, RNA Tagging: Methods and Protocols serves as a vital reference for researchers looking to further the increasingly important research in RNA biology.
RNA Technologies and Their Applications
by Jan Barciszewski Volker A. ErdmannRNA technologies are the driving forces of modern medicine and biotechnology. They combine the fields of biochemistry, chemistry, molecular biology, cell biology, physics, nanotechnology and bioinformatics. The combination of these topics is set to revolutionize the medicine of tomorrow. After more than 15 years of extensive research in the field of RNA technologies, the first therapeutics are ready to reach the first patients. Thus we are witnessing the birth of a very exciting time in the development of molecular medicine, which will be based on the methods of RNA technologies. This volume is the first of a series. It covers various aspects of RNA interference and microRNAs, although antisense RNA applications, hammerhead ribozyme structure and function as well as non-coding RNAs are also discussed. The authors are internationally highly respected experts in the field of RNA technologies.
RNA Therapeutics
by Mouldy SioudCentral to the synthesis of proteins, the performance of catalysis, and many other physiological processes, the aberrant expression of which can be linked to human diseases including cancers, RNA has proven to be key target for therapeutics as well as a tool for therapy. In RNA Therapeutics: Function, Design, and Delivery, expert contributors from a broad spectrum of scientific backgrounds highlight the roles that messenger RNAs and small RNAs can play in biology and medicine. While covering the five major RNA-based drugs, namely the use of ribozymes to cleave and/or correct mRNA transcript, the use of siRNA for targeted silencing of gene transcripts, the use of aptamers, like short RNA molecules, for neutralizing the protein functions, the use mRNA-transfected DCs to activate immune system against tumor cells, as well as the use of RNA to reprogram T and/or DC cell function, this extensive volume brings together the fields of coding (mRNA) and non-coding RNA such as ribozymes, RNAse P, siRNAs, and miRNAs into one convenient source. Written in the highly successful Methods in Molecular BiologyTM series format, the cutting-edge protocol chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and practical tips on troubleshooting and avoiding known pitfalls. Also, the book contains several excellent reviews for teaching purposes. Authoritative and comprehensive, RNA Therapeutics: Function, Design, and Delivery provides key models and tools which will assist researchers in increasing our understanding of RNA functions, modifications, and their involvement in diseases in order to lead to the design of vital new RNA-based therapeutics.
RNA Vaccines: Methods and Protocols (Methods in Molecular Biology #2786)
by Thomas KrampsThis second edition volume expands on the previous edition with discussions of the latest technology and advancements in the development of RNA vaccines and proposed solutions on how to tackle currently unmet medical needs. The chapters in this book are organized into four parts and cover topics such as replication and non-replicating RNA vectors, formulation and delivery of RNA vaccines, and clinical and nonclinical development of RNA vaccines. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Practical and comprehensive, RNA Vaccines: Methods and Protocols, Second Edition is a valuable resource for any researcher interested in learning more about this important and developing field.
RNA Vaccines
by Thomas Kramps Knut ElbersThis volume provides an overview of the field and practical hints for vaccinologists in academia and industry. Chapters provide protocols on self-replicating RNA vectors, non-replication mRNA vectors, adjuvantation and delivery, and preclinical and clinical development. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, RNA Vaccines: Methods and Protocols aims to increased collaboration on RNA vaccines between basic and applied scientists in academia, government, and industry to develop future solutions for today's challenges.
RNA Viruses and Neurological Disorders
by Sabyasachi DashThis volume is an accessible introduction to RNA viruses and the infectious outcomes that they cause in the central nervous system (CNS). Chapters cover the major RNA viruses, their impact on the CNS, and the similarities and differences in pathological outcomes that can be observed. Neuroscientists, be they students, researchers, or clinicians, will benefit from the timely coverage provided. Our understanding of viruses, and specifically RNA viruses and their pathological impact, is rapidly evolving. For example, the close molecular interaction of viruses with the CNS cell types in the human host is poorly understood. Readers can use the book to understand clearly the cellular and molecular mechanisms governing pathological outcomes of RNA virus infection in the cell types of the human brain (e.g., neurons, endothelial cells, astrocytes, resident immune cells) based on summarized case studies, and gain insight into how cell type-specific defects affect brain function and cause poor clinical outcomes. The book is aimed primarily at neuroscience students and postgraduates wishing to learn about virology and professionals who are interested to learn more about virus-associated neuropathology. A basic knowledge of cell and molecular biology is assumed; however, readers across the disciplines of science, technology, engineering, and mathematics will find this topical and timely publication of value.
Road and Off-Road Vehicle System Dynamics Handbook
by Manfred Ploechl Giampiero MastinuFeaturing contributions from industry leaders in their respective fields, this volume presents comprehensive, authoritative coverage of all the major issues involved in road vehicle dynamic behavior. It begins with a short history of road and off-road vehicle dynamics followed by thorough, detailed state-of-the-art chapters on modeling, analysis and optimization in vehicle system dynamics, vehicle concepts and aerodynamics, pneumatic tires and contact wheel-road/off-road, modeling vehicle subsystems, vehicle dynamics and active safety, man-vehicle interaction, intelligent vehicle systems, and road accident reconstruction and passive safety.
Road Expansion in the Peruvian Amazon: The 'Enchantments' of the Manu Road (SpringerBriefs in Latin American Studies)
by Eduardo Salazar Moreira Marcela Palomino-SchalschaThis book provides in-depth insights into the construction of the first road to reach riparian communities and the main access point to a national park in the Amazonian rain forest. It is based on an ethnographic investigation in Peru’s Manu Province in the Amazon, which explored diverse local attitudes towards the construction of a road in the overlapping buffer zone of two protected areas: the Manu National Park and the Amarakaeri Communal Reserve. The book reveals the applicability of Harvey and Knox’s concept of ‘enchantments of infrastructure’ in the case of first roads, but also makes accessible wider debates in political ecology such as territoriality and frontier development. The promise of first roads sparks feelings of aspiration and anticipation of the advent of development through speedy travel, economic connectivity and political integration. Yet these developments seldom take shape as expected. The author explores the perspectives, social dynamics and political maneuvers that influence first road building processes in the Amazon, which have applicability to experiences and strategies of road development elsewhere.
Road from Geochemistry to Geochemometrics
by Surendra P. VermaThis book highlights major problems in the statistical analysis of compositions that have been known for over a century, as well as the corresponding solutions that have been put forward by specialists over the past 30 years. The basic assumptions of normality or multi-normality are pointed out and methods to test and achieve them are also covered. The conventional major and trace element geochemistry and modeling equations are discussed, and are followed by a more sophisticated multidimensional approach to data handling. The book’s main focus is on the use of statistical techniques to facilitate data interpretation. It also highlights the classification (or nomenclature) and tectonic discrimination aspects for both igneous and sedimentary rocks. The book concludes by discussing computer programs that are helping pave the way from geochemistry to geochemometrics. Written by a leading expert in the area of geochemistry, it offers a valuable guide for students and professionals in the area.
Road Map for Sliding Mode Control Design (SpringerBriefs in Mathematics)
by Yury V. Orlov Andrey Polyakov Vadim Utkin Alex PoznyakThis book is devoted to control of finite and infinite dimensional processes with continuous-time and discrete time control, focusing on suppression problems and new methods of adaptation applicable for systems with sliding motions only. Special mathematical methods are needed for all the listed control tasks. These methods are addressed in the initial chapters, with coverage of the definition of the multidimensional sliding modes, the derivation of the differential equations of those motions, and the existence conditions. Subsequent chapters discusses various areas of further research. The book reflects the consensus view of the authors regarding the current status of SMC theory. It is addressed to a broad spectrum of engineers and theoreticians working in diverse areas of control theory and applications. It is well suited for use in graduate and postgraduate courses in such university programs as Electrical Engineering, Control of Nonlinear Systems, and Mechanical Engineering.
The Road to Discovery
by John AlisonThe research presented here includes important contributions on the commissioning of the ATLAS experiment and the discovery of the Higgs boson. The thesis describes essential work on the alignment of the inner tracker during the commissioning of the experiment and development of the electron identification algorithm. The subsequent analysis focuses on the search for the Higgs boson in the WW channel, including the development of a method to model the critical W+jet background. In addition, the thesis provides excellent introductions, suitable for non-specialists, to Higgs physics, to the LHC, and to the ATLAS experiment.
The Road to Einstein's Relativity: Following in the Footsteps of the Giants
by David LythCHOICE Highly Recommended Title, August 2019 <P><P>Expertly guided by renowned cosmologist Dr. David Lyth, learn about the pioneering scientists whose work provided the foundation for Einstein’s formulation of his theories of relativity, and about Einstein's groundbreaking life and work as well. <P><P>This highly readable and accessible panorama of the field delicately balances history and science as it takes the reader on an adventure through the centuries. Without complex mathematics or scientific formulae, this book will be of interest to all, even those without a scientific background, who are intrigued to find out more about what paved the way for one of our most famous physicists to push the boundaries of physics to new lengths. <P><P>Features: <li>Written by an internationally renowned physicist and cosmologist <li>Describes the life and times of Einstein and his important predecessors <li>Focuses on one of the most famous areas of science, Einstein’s Relativity Theory
The Road to Maxwell's Demon
by Meir Hemmo Orly R. ShenkerTime asymmetric phenomena are successfully predicted by statistical mechanics. Yet the foundations of this theory are surprisingly shaky. Its explanation for the ease of mixing milk with coffee is incomplete, and even implies that un-mixing them should be just as easy. In this book the authors develop a new conceptual foundation for statistical mechanics that addresses this difficulty. Explaining the notions of macrostates, probability, measurement, memory, and the arrow of time in statistical mechanics, they reach the startling conclusion that Maxwell's Demon, the famous perpetuum mobile, is consistent with the fundamental physical laws. Mathematical treatments are avoided where possible, and instead the authors use novel diagrams to illustrate the text. This is a fascinating book for graduate students and researchers interested in the foundations and philosophy of physics.
Road to Net Zero: Strategic Pathways for Sustainability-Driven Business Transformation
by Oliver Zipse Joachim Hornegger Thomas Becker Markus Beckmann Michael Bengsch Irene Feige Markus SchoberWith this open access book, delve into the insights of respected leaders from academia and industry as they unravel the intricacies of sustainability-driven business transformation. This meticulously curated edited volume reflects on The Road To Net Zero, underscoring the need for pioneering pathways. Embark on a collaborative learning journey and explore key issues along the road to transformation, such as crafting corporate sustainability strategies, new forms of corporate disclosure, transforming value chains, and harnessing the power of technological innovation. Packed with guiding questions and distilled findings from research, this book is a must-read for all decision-makers, strategists, engaged citizens, educators, and learners committed to driving change and shaping a more sustainable future.
The Road to Reality: A Complete Guide to the Laws of the Universe
by Roger PenroseFrom one of our greatest living scientists, a magnificent book that provides, for the serious lay reader, the most comprehensive and sophisticated account we have yet had of the physical universe and the essentials of its underlying mathematical theory.Since the earliest efforts of the ancient Greeks to find order amid the chaos around us, there has been continual accelerated progress toward understanding the laws that govern our universe. And the particularly important advances made by means of the revolutionary theories of relativity and quantum mechanics have deeply altered our vision of the cosmos and provided us with models of unprecedented accuracy. What Roger Penrose so brilliantly accomplishes in this book is threefold. First, he gives us an overall narrative description of our present understanding of the universe and its physical behaviors–from the unseeable, minuscule movement of the subatomic particle to the journeys of the planets and the stars in the vastness of time and space.Second, he evokes the extraordinary beauty that lies in the mysterious and profound relationships between these physical behaviors and the subtle mathematical ideas that explain and interpret them. Third, Penrose comes to the arresting conclusion–as he explores the compatibility of the two grand classic theories of modern physics–that Einstein’s general theory of relativity stands firm while quantum theory, as presently constituted, still needs refashioning.Along the way, he talks about a wealth of issues, controversies, and phenomena; about the roles of various kinds of numbers in physics, ideas of calculus and modern geometry, visions of infinity, the big bang, black holes, the profound challenge of the second law of thermodynamics, string and M theory, loop quantum gravity, twistors, and educated guesses about science in the near future. In The Road to Reality he has given us a work of enormous scope, intention, and achievement–a complete and essential work of science
The Road to Wisdom: On Truth, Science, Faith and Trust
by Francis S. CollinsFrom world-leading scientist and New York Times bestselling author of The Language of God, a deeply thoughtful guidebook to discerning what and who we can trust to move us from societal discord to civic harmony.As the COVID-19 pandemic revealed, western society has become not just hyper-partisan, but also deeply cynical; distrustful of traditional sources of knowledge and wisdom such as science and faith. Scepticism about vaccines led to the needless deaths of at least 230,000 Americans, and "Do your own research" is now a rallying cry in many online rabbit holes. Yes, experts can make mistakes, and institutions can lose their moral compass, but there are reliable ways and means to weigh information and navigate truth, and The Road to Wisdom is here to help us rediscover them.Francis Collins reminds us of the four core sources of judgement and clear thinking: truth, science, faith, and trust. Drawing on his scientific work at the forefront of the Human Genome Project and the US National Institutes of Health, as well as on ethics, philosophy, and theology, Collins makes a robust, thoughtful case for each of these sources - their reliability, and their limits. Ultimately, he shows how they work together, not separately - and certainly not in conflict. It is only when we re-link these four pillars of wisdom that we can begin to discern the best path forward in life.Hopeful, accessible, winsome, and deeply wise, The Road to Wisdom leads us beyond current animosities to surer footing. Here is the moral, philosophical, and scientific framework with which to address the problems of our time - on the world stage, but also in our daily lives.
The Road to Wisdom: On Truth, Science, Faith and Trust
by Francis S. CollinsFrom world-leading scientist and New York Times bestselling author of The Language of God, a deeply thoughtful guidebook to discerning what and who we can trust to move us from societal discord to civic harmony.As the COVID-19 pandemic revealed, western society has become not just hyper-partisan, but also deeply cynical; distrustful of traditional sources of knowledge and wisdom such as science and faith. Scepticism about vaccines led to the needless deaths of at least 230,000 Americans, and "Do your own research" is now a rallying cry in many online rabbit holes. Yes, experts can make mistakes, and institutions can lose their moral compass, but there are reliable ways and means to weigh information and navigate truth, and The Road to Wisdom is here to help us rediscover them.Francis Collins reminds us of the four core sources of judgement and clear thinking: truth, science, faith, and trust. Drawing on his scientific work at the forefront of the Human Genome Project and the US National Institutes of Health, as well as on ethics, philosophy, and theology, Collins makes a robust, thoughtful case for each of these sources - their reliability, and their limits. Ultimately, he shows how they work together, not separately - and certainly not in conflict. It is only when we re-link these four pillars of wisdom that we can begin to discern the best path forward in life.Hopeful, accessible, winsome, and deeply wise, The Road to Wisdom leads us beyond current animosities to surer footing. Here is the moral, philosophical, and scientific framework with which to address the problems of our time - on the world stage, but also in our daily lives.
Road Trip!: Camping with the Four Vagabonds: Thomas Edison, Henry Ford, Harvey Firestone, and John Burroughs
by Claudia FriddellJoin Thomas Edison, Henry Ford, Harvey Firestone, and John Burroughs on their pioneering camping trips during the early 1900s in this energetic and entertaining nonfiction picture-book adventure.After years of inventing things that other people needed, Thomas Edison and Henry Ford realized there was something they needed—a vacation! So, the famous inventors packed up Ford's Model T and invited their good friends Harvey Firestone and John Burroughs to join them as "the Four Vagabonds" hit America's back roads to enjoy the country's natural beauty, fireside chats, and frolicking fun with friends—all while inspiring future generations to invent camping adventures of their own.&“Buckle yourself in as Claudia Friddell and Jeremy Holmes take you on a fun, creative, and certainly unique road trip with America&’s most famous vagabonds—Thomas Edison, Henry Ford, Harvey Firestone, and John Burroughs. The colorful and spirited illustrations, the stories of the Vagabond&’s bivouacking travels and campsite escapades, and the well-researched bibliography makes Road Trip! a great addition to any child&’s library!&” —Matt Andres, curatorial registrar, Edison and Ford Winter Estates
Road Vehicle Automation (Lecture Notes In Mobility Ser.)
by Gereon Meyer Sven BeikerThis contributed volume covers all relevant aspects of road vehicle automation including societal impacts, legal matters, and technology innovation from the perspectives of a multitude of public and private actors. It is based on an expert workshop organized by the Transportation Research Board at Stanford University in July 2013. The target audience primarily comprises academic researchers, but the book may also be of interest to practitioners and professionals. Higher levels of road vehicle automation are considered beneficial for road safety, energy efficiency, productivity, convenience and social inclusion. The necessary key technologies in the fields of object-recognition systems, data processing and infrastructure communication have been consistently developed over the recent years and are mostly available on the market today. However, there is still a need for substantial research and development, e.g. with interactive maps, data processing, functional safety and the fusion of different data sources. Driven by stakeholders in the IT industry, intensive efforts to accelerate the introduction of road vehicle automation are currently underway.
Roadmap for Global Sustainability — Rise of the Green Communities: Rise Of The Green Communities (Advances in Science, Technology & Innovation)
by Salah El-Haggar Aliaa SamahaProgressive increases in consumer demands along with aggressive industrial consumption led the world to proximate resource depletion, weather changes, soil and air degradation and water quality deterioration. We now know that the paradigm of production at the expense of human condition is not sustainable. This book briefly explains how we reached this situation and offers suggestions as to what can be done to overcome it. It invites the best entrepreneurial talent and scientific and technological know-how to develop a sustainable economy around sustainable communities, services, and sectors. A major obstacle previously identified by involved parties was the ability of accommodating for the emerging economic growth without causing harm to the environment, especially with resource depletion. This book provides the solution by creating a need to bring on a new revolution that preserves the rights of next generations to live in a healthy environment This Sustainability Revolution requires the integration of economic, environmental, and social factor as well as the practical aspects of implementing sustainability through green activities, which are discussed throughout the book. In this book, a globalization is proposed that encourages creativity and innovation towards sustainability. With this global sustainability approach (real globalization) both rich and poor will benefit from the global sustainability approach. This will close the gap between rich and poor. Developing countries could reap the benefit of current technology without undergoing many of the growing pains associated with development of these technologies. Governments are able to better work together towards common goals now that there is an advantage in cooperation, an improved ability to interact and coordinate, and a global awareness of issues. The book presents a sustainability roadmap to bring together various concepts, that have been dealt with independently by previous authors, and link them to establish the fundamental practical steps. The flow path and the direction for successful implementation of a sustainability roadmap are also discussed in detail in the book. For the first time, the authors use sustainable communities to create a better quality of life for residents while minimizing the use of the resources to meet current needs and ensure adequate resources for future generations. These green communities create new industries for the local economy and improve public health, which offers more hope for their citizens. Sustainable transportation, renewable energy, recycling, clean water, and urban forests help to make a more livable community and help to control the global climate change. They involve all citizens and incorporate local values into decision-making.
A Roadmap for Plant Genome Editing
by Agnès Ricroch Dennis Eriksson Dragana Miladinović Jeremy Sweet Katrijn Van Laere Ewa Woźniak-GientkaThis open access book is an update of genome editing techniques applied to a range of plants. We discuss the latest techniques and applications to cereals, roots and tubers, oilseed crops, fruit and forest trees, vegetables, legumes and algae including resistance to biotic and abiotic stresses, improved quality, drug production, yield and adaptation to climate change. The regulations in different countries worldwide, the patentibility and the perception by society of the applications of new genomic techniques are examined. This book is written by a multidisciplinary and multisectoral collective of high-profile scientists and other experts belonging to the COST Action network PlantEd, which is mainly European but with contributions from American, Australian, Canadian, Chinese, Indian, Iranian, Pakistani and Peruvian scientists. The book is aimed at a wide audience consisting of students, academics, private and public breeders, other actors in the food and bioeconomy value chains and policy and law makers.This is an open access book.
A Roadmap to Industry 4.0: Smart Production, Sharp Business and Sustainable Development (Advances in Science, Technology & Innovation)
by Anand Nayyar Akshi KumarBusiness innovation and industrial intelligence are paving the way for a future in which smart factories, intelligent machines, networked processes and Big Data are combined to foster industrial growth. The maturity and growth of instrumentation, monitoring and automation as key technology drivers support Industry 4.0 as a viable, competent and actionable business model. This book offers a primer, helping readers understand this paradigm shift from industry 1.0 to industry 4.0. The focus is on grasping the necessary pre-conditions, development & technological aspects that conceptually describe this transformation, along with the practices, models and real-time experience needed to achieve sustainable smart manufacturing technologies. The primary goal is to address significant questions of what, how and why in this context, such as:What is Industry 4.0?What is the current status of its implementation?What are the pillars of Industry 4.0?How can Industry 4.0 be effectively implemented?How are firms exploiting the Internet of Things (IoT), Big Data and other emerging technologies to improve their production and services?How can the implementation of Industry 4.0 be accelerated?How is Industry 4.0 changing the workplace landscape?Why is this melding of the virtual and physical world needed for smart production engineering environments?Why is smart production a game-changing new form of product design and manufacturing?
A Roadmap to the Successful Development and Commercialization of Microbial Pest Control Products for Control of Arthropods (Progress in Biological Control #10)
by Willem J. RavensbergBiocontrol is among the most promising methods for a safe, environmentally benign and sustainable pest control. Microbial pesticides offer a great potential, and it is anticipated that they will become a substantial part of the use of all crop protection products. Their development and commercialization, however, has been difficult and with many failures. In this book a rational and structured roadmap has been designed for the development and commercialization of microbial pest control products for the control of arthropod pests. The building blocks of the entire process are identified and essential aspects highlighted. Biopesticides based on entomopathogenic bacteria, fungi, viruses and nematodes are elaborately discussed. This systematic roadmap with a strong focus on economics and market introduction will assist academic researchers and industrial developers of biopesticides in accomplishing their goal: the development of successful cost-effective microbial pesticides.