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Progress In Nonhistone Protein Research: Volume III
by I. BekhorAs a follow-up to Volumes I and II in this series, in this volume the authors attempt to provide an update into the current research in NHCP with the hope that these articles may foster a more analytical elucidation of the role of these proteins in gene expression.
Progress in Nonhistone Protein Research: Volume I
by I. Bekhor IsaacThe purpose of this text is to encourage research on nonhistones and to stimulate the imagination of other investigators whose future efforts might result in new discoveries as to the significance of these proteins.
Progress in Nonhistone Protein Research: Volume II
by I. Bekhor IsaacThe purpose of this text is to encourage research on nonhistones and to stimulate the imagination of other investigators whose future efforts might result in new discoveries as to the significance of these proteins.
Progress in Nonlinear Nano-Optics
by Shuji Sakabe Christoph Lienau Rüdiger GrunwaldThis book presents the state of the art in nonlinear nanostructures for ultrafast laser applications. Most recent results in two emerging fields are presented: (i) generation of laser-induced nanostructures in materials like metals, metal oxides and semiconductors, and (ii) ultrafast excitation and energy transfer in nanoscale physical, chemical and hybrid systems. Particular emphasis is laid on the up-to-date controversially discussed mechanisms of sub-wavelength ripple formation including models of self-organized material transport and multiphoton excitation channels, nonlinear optics of plasmonic structures (nanotips, nanowires, 3D-metamaterials), and energy localization and transport on ultrafast time scale and spatial nanoscale. High-resolution spectroscopy, simulation and characterization techniques are reported. New applications of ultrashort-pulsed lasers for materials processing and the use of nanostructured materials for characterizing laser fields and laser-matter-interactions are discussed.
Progress in Optomechatronic Technologies: Proceedings of International Symposium on Optomechatronic (2018) (Springer Proceedings in Physics #233)
by Amalia Martínez-García Indrani Bhattacharya Yukitoshi Otani Rainer TutschThis book gathers high-quality papers presented at the International Symposium on Optomechatronic Technology (ISOT 2018), which was organized by the International Society for Optomechatronics (ISOM) and Centro de Investigaciones en Óptica (CIO) in Cancun, Mexico on November 5–8, 2018. The respective papers address the evolution of optomechatronic devices and systems, and their implementation in problem-solving and various other applications. Moreover, they cover a broad range of topics at the interface of optical, mechanical and electrical technologies and methods.
Progress in Optomechatronics: Proceedings of the 20th International Symposium on Optomechatronic Technology (ISOT 2019), India (Springer Proceedings in Physics #249)
by Indrani Bhattacharya Yukitoshi Otani Philippe Lutz Sudhir CherukulappurathThis book presents peer-reviewed articles from the 20th International Symposium on Optomechatronic Technologies (ISOT 2019), held in Goa, India. The symposium brought together students, researchers, professionals, and academicians in the field of optomechatronics and related areas on a common platform conducive to academic interaction with business professionals.
Progress in Parasitology
by Heinz MehlhornParasites threaten the health of animals and humans alike. Especially in times of increasing globalization and global warming, parasites can enlarge their "kingdom" by spreading. At the same time many of the existing medical products have become ineffective. As these products have been used for many decades, parasites have developed resistances, so that they have progressed in their fight for survival. Therefore it is obvious that humans must develop new methods to face these dangers. Thus parasitological knowledge increases daily and must be formulated to be accessible for as many parasitologists (veterinarians, physicians, biologists) as possible. Therefore it is necessary that reviews reflecting the present status of the progress in many fields of research be published. Therefore this book, published on the occasion of the 50th anniversary of the German Society of Parasitology, compiles 18 reviews on recent "hot topics," including a new vaccine against malarial parasites; severe diseases with poor chances of treatment (cryptosporidiosis, coccidiosis, theileriosis); vectors (mosquitoes, ticks) and their transmission activities; and fish parasites, including molecular insights into the sex of parasites with a focus on the survival abilities that made them so dangerous. These chapters provide detailed information for researchers, as well as for teachers and students in parasitology.
Progress in Photon Science: Emerging New Directions (Springer Series in Chemical Physics #125)
by Kaoru Yamanouchi Alina A. Manshina Vladimir A. MakarovThis book summarizes the latest findings by leading researchers in the field of photon science in Russia and Japan. It discusses recent advances in the field of photon science and chemistry, covering a wide range of topics, including photochemistry and spectroscopy of novel materials, magnetic properties of solids, photobiology and imaging, and spectroscopy of solids and nanostructures. Based on lectures by respected scientists at the forefront of photon and molecular sciences, the book helps keep readers abreast of the current developments in the field.
Progress in Photorefractive Nonlinear Optics
by Kazoo KurodaThis monograph collects together papers by leading researchers in the field of photorefractive nonlinear optics. All of the works are presented by eminent researchers in their field and cover topics such as wave mixing in nonlinear optical materials; photorefractive semiconductors; organic photorefractive materials and volume holographic storage.
Progress in Planar Optical Waveguides
by Xianping Wang Cheng Yin Zhuangqi CaoThis book provides a comprehensive description of various slab waveguide structures ranged from graded-index waveguide to symmetrical metal-cladding waveguide. In this book, the transfer Matrix method is developed and applied to analyze the simplest case and the complex generalizations. A novel symmetrical metal-cladding waveguide structure is proposed and systematically investigated for several issues of interest, such as biochemical sensing, Goos-Hänchen shift and the slow light effect, etc. Besides, this book summarizes the authors' research works on waveguides over the last decade. The readers who are familiar with basic optics theory may find this book easy to read and rather inspiring.
Progress in Solar Energy Technology and Applications
by Umakanta SahooEnergy is one of the most important topics of our time, and renewable energy has been a long and still-unfolding story that has taken decades to bring us to where we are today. Even after so much progress, engineers and scientists are always still developing new and innovative techniques, processes, equipment, and materials to further the science and fulfill the mission of generating cleaner, renewable energy for the world’s consumption. This new groundbreaking series, Advances in Renewable Energy, covers these topics across the spectrum, including solar, wind, and other renewable energy sources. This first volume in the series focuses on solar energy, probably the fastest-growing and developing area of renewable energy. With new materials and processes constantly coming online, it is important for engineers and scientists to stay abreast of the state-of-the-art in the field, and this volume does just that. Covering not just the basics of the technology and technological advances, the contributors delve into the financial aspects of solar energy systems as well. They look at total costs, not just initial costs, but the costs of maintenance, as well, Covering nearly every aspect of solar energy systems and the latest advances in the field, this is a must-have volume for any engineer, scientist, student, or educator working in or studying solar energy.
Progress in Structural Engineering, Mechanics and Computation: Proceedings of the Second International Conference on Structural Engineering, Mechanics and Computation, Cape Town, South Africa, 5-7 July 2004
by Alphose ZingoniThe Second International Conference on Structural Engineering Mechanics and Computation was held in Cape Town, South Africa in 2004. Its mission was 'To review and share the latest developments, and address the challenges that the present and the future pose'.This book contains its key findings with contributions from academics, researchers and pra
Progress in Sustainable Aviation (Sustainable Aviation)
by T. Hikmet Karakoc Can Ozgur Colpan Alper DalkiranProgress in Sustainable Aviation looks at recent progress and new technological developments in sustainable aviation, presenting readers with engineering solutions and methodologies for efficiency and cost savings, performance improvement, and emission reduction. Coverage includes alternative fuel types, propulsion technologies, and emission technologies used in different aerial vehicles, such as unmanned aerial vehicles, drones, and passenger aircraft. Operational areas, such as the building of green airports, commercial air transport, and maintenance management are also addressed. This collection will be a valuable reference for researchers, practicing engineers, scientists, and students working in the area of sustainable aviation technology and management. Looks at recent progress in sustainable aviation technologies;Presents alternative aviation fuel types and propulsion technologies;Includes case studies and practical applications.
Progress in Sustainable Manufacturing (Management and Industrial Engineering)
by Jayakrishna Kandasamy Aravind Raj Sakthivel J. Paulo DavimThis book provides recent developments in sustainable manufacturing ranging from product designing to product delivery. It focuses on key challenges and solutions at various stages such as product design, material selection, material processing, manufacturing and energy consumption to ensure sustainability at every stage of product lifecycle. It further offers solutions to build sustainable product by responsible consumption and production. The role of advanced technologies in sustainable manufacturing is also covered in this book. Given the topics covered, this book will be useful for the researchers and professionals working in the area of mechanical engineering, especially industrial and production engineering.
Progress in the Chemistry of Organic Natural Products 100
by A. D. Kinghorn H. Falk J. KobayashiThe volumes of this classic series, now referred to simply as "Zechmeister" after its founder, L. Zechmeister, have appeared under the Springer Imprint ever since the series' inauguration in 1938. It is therefore not really surprising to find out that the list of contributing authors, who were awarded a Nobel Prize, is quite long: Kurt Alder, Derek H. R. Barton, George Wells Beadle, Dorothy Crowfoot-Hodgkin, Otto Diels, Hans von Euler-Chelpin, Paul Karrer, Luis Federico Leloir, Linus Pauling, Vladimir Prelog, with Walter Norman Haworth and Adolf F. J. Butenandt serving as members of the editorial board. The volumes contain contributions on various topics related to the origin, distribution, chemistry, synthesis, biochemistry, function or use of various classes of naturally occurring substances ranging from small molecules to biopolymers. Each contribution is written by a recognized authority in his field and provides a comprehensive and up-to-date review of the topic in question. Addressed to biologists, technologists and chemists alike, the series can be used by the expert as a source of information and literature citations and by the non-expert as a means of orientation in a rapidly developing discipline.
Progress in the Chemistry of Organic Natural Products 101
by A. Douglas Kinghorn Heinz Falk Simon Gibbons Jun'Ichi KobayashiThe volumes of this classic series, now referred to simply as "Zechmeister" after its founder, Laszlo Zechmeister, have appeared under the Springer Imprint ever since the series' inauguration in 1938. The series has featured contributions by seven Nobel laureates: D. H. R. Barton, D. Crowfoot Hodgkin, L. Pauling, K. Alder, O. Diels, P. Karrer, and H. von Euler-Chelpin. The volumes contain contributions on various topics related to the origin, distribution, chemistry, synthesis, biochemistry, function or use of various classes of naturally occurring substances ranging from small molecules to biopolymers. Each contribution is written by a recognized authority in the field and provides a comprehensive and up-to-date review of the topic in question. Addressed to biologists, technologists, and chemists alike, the series can be used by the expert as a source of information and literature citations and by the non-expert as a means of orientation in a rapidly developing discipline.
Progress in the Chemistry of Organic Natural Products 102
by A. Douglas Douglas Kinghorn Heinz Falk Simon Gibbons Jun'Ichi KobayashiThe first contribution reviews the phytochemical, chemical,and biological literature on members of the ingenane class of diterpenoids fromtheir first isolation in 1968 through 2015, highlighting unresolved issues bothcommon to phorboids and specific to ingenol derivatives. The biogenesis of ingenol is discussed in thelight of the Jakupovic proposal of a dissection between the formation of the macrocyclicEuphorbia diterpenoids and the phorboids,and the clinical development of ingenol mebutate is chronicled in the light ofits "reverse-pharmacology" focus. The second contributionoffers a comprehensive view of the chemical wealth and the taxonomic problemscurrently impeding chemical and biological investigations of the genus Laurencia. It addresses the botanical description and the growth andpopulation dynamics of the genus, as well as its chemical diversity and ecologicalrelations; the secondary metabolites as well as their sources of isolation; and finally the biological activity.
Progress in the Chemistry of Organic Natural Products 104 (Progress in the Chemistry of Organic Natural Products #104)
by A. Douglas Kinghorn Heinz Falk Simon Gibbons Jun'Ichi KobayashiThe first contribution describes apolar and polar molecular fossils and, in particular biomarkers, along the lines usually followed in organic chemistry textbooks, and points to their bioprecursors when available. Thus, the apolar compounds are divided in linear and branched alkanes followed by alicyclic compounds and aromatic and heterocyclic molecules, and, in particular, the geoporphyrins. The polar molecular fossils contain as functional groups or constituent units ethers, alcohols, phenols, carbonyl groups, flavonoids, quinones, and acids, or are polymers like kerogen, amber, melanin, proteins, or nucleic acids. The final sections discuss the methodology used and the fundamental processes encountered by the biomolecules described, including diagenesis, catagenesis, and metagenesis. The second contribution covers the distribution of phthalides in nature and the findings in the structural diversity, chemical reactivity, biotransformations, syntheses, and bioactivity of natural and semisynthetic phthalides.
Progress in the Chemistry of Organic Natural Products 105
by A. Douglas Kinghorn Heinz Falk Simon Gibbons Jun'Ichi KobayashiThe first contribution reviews the occurrence of xanthine alkaloids in the plant kingdom and the elucidation of the caffeine biosynthesis pathway, providing details of the N-methyltransferases, belonging to the motif B' methyltransferase family which catalyze three steps in the four step pathway leading from xanthosine to caffeine. The second contribution in this book provides a background on the molecule and related compounds and update knowledge on the most recent advances in Iboga alkaloids. The third contribution presents a comprehensive analysis of frequently occurring errors with respect to 13C NMR spectroscopic data and proposes a straightforward protocol to eliminate a high percentage of the most obvious errors.
Progress in the Chemistry of Organic Natural Products 107 (Progress in the Chemistry of Organic Natural Products #107)
by Jun'Ichi Kobayashi Ji-Kai Liu Yoshinori Asakawa Simon Gibbons Heinz Falk A. Douglas KinghornThe first review describes examples of very promising compounds discovered from plants acquired from Africa, Southeast Asia, the Americas, and the Caribbean region with potential anticancer activity. These include plant secondary metabolites of the diphyllin lignan, penta[b]benzofuran, triterpenoid, and tropane alkaloid types. The second review presents 40 more erythrinan alkaloids, which were either new or were missed out in the last major reviews, bringing to a total of 154 known erythrinan alkaloids known to date. The reported pharmacological activities of the new and known alkaloids showed a greater bias towards central nervous system and related activities. Other prominent activities reported were antifeedant or insecticidal, cytotoxicity/antitumor/anticancer/estrogenic, antiprotozoal, antiinflammatory, antioxidant, antifungal and antiviral activities.
Progress in the Chemistry of Organic Natural Products 108 (Progress in the Chemistry of Organic Natural Products #108)
by A. Douglas Kinghorn Heinz Falk Simon Gibbons Yoshinori Asakawa Ji-Kai Liu Jun'Ichi KobayashiThe first contribution summarizes current trends in research on medicinal plants in Mexico with emphasis on work carried out at the authors' laboratories. The most relevant phytochemical and pharmacological profiles of a selected group of plants used widely for treating major national health problems are described. The second contribution provides a detailed survey of the so far reported literature data on the capacities of selected oxyprenylated phenylpropanoids and polyketides to trigger receptors, enzymes, and other types of cellular factors for which they exhibit a high degree of affinity and therefore evoke specifice responses. And the third contribution discusses aspects of endophytic actinobacterial biology and chemistry, including biosynthesis and total synthesis of secondary metabolites produced in culture. It also presents perspectives fo the future of microbial biodiscovery, with emphasis on the seondary metabolism of endophytic actinobacteria.
Progress in the Chemistry of Organic Natural Products 109 (Progress in the Chemistry of Organic Natural Products #109)
by A. Douglas Kinghorn Heinz Falk Simon Gibbons Yoshinori Asakawa Jun’ichi Kobayashi Ji-Kai LiuThis volume comprises three reviews. The first describes isolation, structure determination, syntheses, and biochemistry of the low molecular weight compounds of the secretion of exocrine glands of termies with emphasis to pheromones and defensive compounds. The second review describes recent studies on isolation and structure elucidation of bioactive compounds involved in the life cycle and determination of the molecular mechanisms of the developmental events observed in higher plants. The third contribution reports on the current body of knowledge of African propolis, with a particular emphasis on its chemistry and biological activity.
Progress in the Chemistry of Organic Natural Products 110: Cheminformatics in Natural Product Research (Progress in the Chemistry of Organic Natural Products #110)
by A. Douglas Kinghorn Heinz Falk Simon Gibbons Jun’ichi Kobayashi Yoshinori Asakawa Ji-Kai LiuThe book summarizes important aspects of cheminformatics that are relevant for natural product research. It highlights cheminformatics tools that help to match natural products with their respective biological targets or off-targets, and discusses the potential and limitations of this approach.
Progress in the Chemistry of Organic Natural Products 111 (Progress in the Chemistry of Organic Natural Products #111)
by A. Douglas Kinghorn Heinz Falk Simon Gibbons Yoshinori Asakawa Jun’ichi Kobayashi Ji-Kai LiuThe first chapter in volume 111 summarizes research on the sesterterpenoids, which are known as a relatively small group of natural products. However, they express a variety of simple to complicated chemical structures. This chapter focuses on the chemical structures of sesterterpenoids and how their structures are synthesized in Nature. The second chapter is devoted to marine-derived fungi, which play an important role in the search for structurally unique secondary metabolites, some of which show promising pharmacological activities that make them useful leads for drug discovery. Marine natural product research in China in general has made enormous progress in the last two decades as described in this chapter on fungal metabolites. This contribution covers 613 new natural products reported from 2001 to 2017 from marine-derived fungi obtained from algae, sponges, corals, and other marine organisms from Chinese waters.
Progress in the Chemistry of Organic Natural Products 112 (Progress in the Chemistry of Organic Natural Products #112)
by A. Douglas Kinghorn Heinz Falk Simon Gibbons Jun’ichi Kobayashi Yoshinori Asakawa Ji-Kai LiuThe first chapter describes the oldest method of communication between living systems in Nature, the chemical language. Plants, due to their lack of mobility, have developed the most sophisticated way of chemical communication. Despite that many examples involve this chemical communication process - allelopathy, there is still a lack of information about specific allelochemicals released into the environment, their purpose, as well as in-depth studies on the chemistry underground. These findings are critical to gain a better understanding of the role of these compounds and open up a wide range of possibilities and applications, especially in agriculture and phytomedicine. The most relevant aspects regarding the chemical language of plants, namely, kind of allelochemicals have been investigated, as well as their releasing mechanisms and their purpose, are described in this chapter. The second chapter is focused on the natural products obtained from Hypericum L., a genus of the family Hypericaceae within the dicotyledones. Hypericum has been valued for its important biological and chemical properties and its use in the treatment of depression and as an antibacterial has been well documented in primary literature and ethnobotanical reports. The present contribution gives a comprehensive summary of the chemical constituents and biological effects of this genus. A comprehensive account of the chemical constituents including phloroglucinol derivatives, xanthones, dianthrones, and flavonoids is included. These compounds show a diverse range of biological activities that include antimicrobial, cytotoxic, antidepressant-like, and antinociceptive effects. The third chapter addresses microtubule stabilizers, which are a mainstay in the treatment of many solid cancers and are often used in combination with molecularly targeted anticancer agents and immunotherapeutics. The taccalonolides are a unique class of such microtubule stabilizers isolated from plants of Tacca species that circumvent clinically relevant mechanisms of drug resistance. Although initial reports suggested that the microtubule stabilizing activity of the taccalonolides is independent of direct tubulin binding, additional studies have found that potent C-22,23 epoxidated taccalonolides covalently bind the Aspartate 226 residue of β-tubulin and that this interaction is critical for their microtubule stabilizing activity. Some taccalonolides have demonstrated in vivo antitumor efficacy in drug-resistant tumor models with exquisite potency and long-lasting antitumor efficacy as a result of their irreversible target engagement. The recent identification of a site on the taccalonolide scaffold that is amenable to modification has provided evidence of the specificity of the taccalonolide-tubulin interaction and the opportunity to further optimize the targeted delivery of the taccalonolides to further improve their anticancer efficacy and potential for clinical development.